Hub : Genes

Igfbp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Igfbp4 0.04 0.02 6.9e-05 0.03 0.03 0.03 0.03 4.7e-04 3.0e-04 1.5e-04 2.1e-04
2 IC gene expression Igfbp4 0.32 0.17 1.7e-09 0.23 0.2 0.22 0.22 4.8e-10 9.5e-09 8.3e-10 9.0e-10
3 Brain mRNA stability Igfbp4 0.08 0.05 9.5e-08 0.07 0.08 0.07 0.07 8.3e-07 9.2e-08 2.4e-07 1.7e-07
4 Brain gene expression Igfbp4 0.31 0.11 0.0e+00 0.25 0.25 0.24 0.25 1.4e-23 4.7e-23 1.9e-22 5.9e-23
5 Adipose gene expression Igfbp4 0.59 0.15 0.0e+00 0.47 0.17 0.45 0.44 6.0e-59 3.6e-18 1.2e-55 9.0e-53
6 Liver mRNA stability Igfbp4 0.16 0.11 1.2e-08 0.06 0.06 0.02 0.05 1.0e-07 1.6e-07 5.6e-03 4.3e-06
7 OFC gene expression Igfbp4 0.52 0.18 8.7e-08 0.29 0.25 0.28 0.29 1.2e-07 1.5e-06 2.0e-07 1.2e-07
8 pVTA gene expression Igfbp4 0.12 0.08 5.1e-10 0.13 0.12 0.12 0.12 1.6e-10 7.1e-10 5.1e-10 3.2e-10
9 PL gene expression Igfbp4 0.05 0.03 1.3e-06 0.04 0.04 0.04 0.04 7.8e-05 1.2e-05 1.0e-04 9.9e-05
10 NAcc gene expression Igfbp4 0.03 0.02 1.3e-03 0 0.01 0.01 0.01 9.9e-02 5.2e-03 4.2e-02 8.7e-03
11 Adipose mRNA stability Igfbp4 0.44 0.2 0.0e+00 0.24 0.13 0.25 0.23 3.6e-26 1.0e-14 9.8e-28 2.6e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.93.44.8-2.22.11.71.3-2.2-2.22.0-2.0-1.5-0.2-2.1
Area under the delay curve0.30.41.0-0.60.50.60.5-0.5-0.50.5-0.6-1.0-0.8-0.4
BMI with tail2.58.711.83.3-3.0-3.4-3.42.72.7-2.62.63.23.21.7
BMI without tail0.84.26.32.3-2.0-2.4-2.51.81.8-1.81.72.22.50.9
Body weight6.327.535.45.8-5.6-5.9-6.05.15.1-5.04.95.35.03.8
Weight adjusted by age0.10.21.10.3-0.7-0.6-0.60.00.0-0.10.10.21.0-0.0
Bone surface0.20.32.3-0.30.4-0.3-0.6-0.3-0.30.2-0.20.51.5-0.5
Bone volume0.30.62.9-0.50.7-0.1-0.5-0.7-0.70.6-0.50.41.7-0.9
Breakpoint value in progressive ratio session0.00.00.30.2-0.50.00.1-0.1-0.10.0-0.1-0.10.10.2
Number of licking bursts0.10.31.7-0.00.4-0.0-0.2-0.4-0.40.5-0.60.51.3-0.6
Context. condit. distance diff. score1.41.73.60.8-1.4-0.7-0.51.41.4-1.51.80.2-1.21.9
Locomotion velocity, session 10.60.71.20.9-0.6-1.0-1.10.60.6-0.60.70.81.10.6
Locomotion distance, session 12.43.15.01.9-1.4-2.1-2.21.41.4-1.51.72.02.20.8
Locomotion velocity, session 20.10.10.20.3-0.3-0.3-0.30.40.4-0.30.30.20.10.4
Locomotion distance, session 20.40.52.70.6-0.1-0.8-0.90.10.1-0.10.10.81.6-0.6
Locomotion velocity, session 30.10.10.3-0.40.10.40.50.10.10.3-0.1-0.4-0.6-0.1
Locomotion distance, session 30.20.20.40.6-0.7-0.5-0.40.50.5-0.30.40.60.50.1
Stereotopy head waving bouts, day 32.42.94.6-1.91.81.92.0-1.4-1.41.4-1.6-2.1-1.8-1.1
Stereotopy head waving duration, day 30.20.20.6-0.60.60.40.4-0.2-0.20.1-0.3-0.8-0.6-0.2
Locomotion velocity, session 71.31.42.91.2-1.0-1.3-1.41.11.1-0.80.91.61.70.6
Locomotion distance, session 70.60.71.91.0-0.6-0.8-0.90.60.6-0.60.81.41.10.3
Stereotopy head waving bouts, day 70.50.61.1-0.90.60.80.7-0.8-0.80.9-0.8-1.0-0.3-0.8
Stereotopy head waving duration, day 70.30.41.2-0.70.30.50.5-0.5-0.50.6-0.6-1.1-0.5-0.5
Locomotion velocity, session 86.88.311.23.0-3.1-2.9-2.83.13.1-3.13.32.41.02.9
Locomotion distance, session 81.31.82.71.4-1.4-1.5-1.61.31.3-1.41.71.20.91.1
Degree of sensitization distance1.01.11.61.2-0.8-1.0-1.11.01.0-1.21.21.30.61.0
Degree of sensitization stereotypy0.50.61.0-0.90.60.70.5-0.8-0.81.0-0.8-0.9-0.2-0.8
Conditioned locomotion0.30.40.7-0.70.40.70.7-0.4-0.40.5-0.5-0.8-0.7-0.3
Cocaine response after cond. corrected0.30.50.9-0.60.80.2-0.1-0.8-0.80.8-0.9-0.60.6-1.0
Cocaine response after cond. not corrected0.40.61.0-0.70.80.2-0.1-0.9-0.90.9-0.9-0.50.8-1.0
Cocaine response before conditioning0.00.00.1-0.20.20.30.3-0.2-0.20.10.0-0.0-0.20.0
Saline control response0.60.91.40.8-0.8-1.1-1.20.90.9-0.90.90.91.00.7
Bone: connectivity density3.04.86.8-2.62.52.21.9-2.5-2.52.3-2.3-1.9-0.6-2.3
Bone: cortical apparent density4.87.610.5-3.02.63.23.2-2.7-2.72.5-2.4-2.9-3.1-1.7
Bone: cortical area0.00.10.2-0.50.30.30.3-0.3-0.30.3-0.3-0.20.1-0.2
Bone: cortical porosity0.30.30.5-0.50.50.2-0.0-0.7-0.70.6-0.5-0.40.5-0.6
Bone: cortical porosity0.10.10.7-0.20.3-0.3-0.5-0.3-0.30.3-0.1-0.10.8-0.3
Bone: cortical thickness1.11.82.7-1.61.11.51.6-1.2-1.21.2-1.1-1.6-1.5-0.7
Bone: cortical thickness5.06.19.1-3.02.62.62.4-2.4-2.42.3-2.3-3.0-2.2-1.7
Bone: cortical tissue density4.87.610.4-3.02.63.23.2-2.7-2.72.5-2.4-2.9-3.0-1.7
Condit. Reinf. active minus inactive responses1.41.62.7-1.31.01.41.5-1.1-1.11.2-1.2-1.6-1.6-0.8
Condit. Reinf. active-inactive response ratio1.92.03.8-1.51.01.71.9-1.1-1.11.1-1.4-1.7-1.9-0.7
Condit. Reinf. active responses1.21.52.2-1.31.11.31.4-1.1-1.11.2-1.2-1.4-1.5-0.8
Condit. Reinf. inactive responses0.10.10.3-0.30.50.1-0.0-0.3-0.30.5-0.3-0.10.2-0.4
Incentive salience index mean2.02.53.2-1.81.61.81.8-1.5-1.51.6-1.7-1.6-1.3-1.2
Condit. Reinf. lever presses1.01.42.4-1.41.61.31.1-1.3-1.31.4-1.3-0.7-0.2-1.0
Condit. Reinf. active minus inactive responses0.81.22.0-1.01.21.11.0-1.3-1.31.4-1.3-0.60.1-1.1
Condit. Reinf. active-inactive response ratio0.71.01.7-0.91.20.80.7-1.2-1.21.3-1.2-0.40.4-1.3
Condit. Reinf. active responses1.31.93.1-1.31.51.31.1-1.6-1.61.8-1.7-0.80.2-1.4
Condit. Reinf. inactive responses1.01.52.3-1.31.41.11.0-1.4-1.41.5-1.5-0.90.0-1.2
Condit. Reinf. lever presses0.10.20.5-0.30.20.50.7-0.3-0.30.3-0.5-0.4-0.4-0.1
Condit. Reinf. lever reinforcers received1.52.13.2-1.51.61.51.4-1.6-1.61.8-1.8-1.0-0.1-1.4
Conditioned reinforcement - actives0.00.10.20.00.10.30.4-0.1-0.10.3-0.40.1-0.20.1
Conditioned reinforcement - inactives0.10.30.4-0.30.60.50.5-0.6-0.60.2-0.4-0.2-0.6-0.6
Conditioned locomotion0.30.51.0-0.50.80.70.8-0.7-0.70.8-1.0-0.20.2-0.7
Patch foraging indifference point 0 sec0.92.64.3-1.81.72.02.1-1.6-1.61.6-1.6-1.2-1.2-1.3
Patch foraging indifference point AUC0.00.00.2-0.20.1-0.2-0.40.10.10.10.20.00.30.1
Delay disc. indifference point, 0s delay1.41.62.7-1.61.41.41.2-1.3-1.31.3-1.3-1.2-0.6-1.1
Delay disc. indifference point, 16s delay0.60.84.1-0.80.50.80.7-0.3-0.30.2-0.1-1.6-2.00.2
Delay disc. indifference point, 2s delay0.70.81.4-1.01.20.70.6-1.1-1.11.0-1.0-0.50.3-1.1
Delay disc. indifference point, 24s delay0.10.20.40.6-0.6-0.1-0.20.40.4-0.40.40.1-0.40.5
Delay disc. indifference point, 4s delay1.11.12.1-1.20.91.00.9-1.0-1.01.1-1.3-1.5-0.8-0.8
Delay disc. indifference point, 8s delay0.00.10.2-0.20.20.30.3-0.2-0.20.3-0.4-0.2-0.1-0.3
Indifference point function ln k0.10.21.00.1-0.20.30.60.30.3-0.40.1-0.4-1.00.4
Indifference point function log k0.10.21.00.1-0.20.30.60.30.3-0.40.1-0.4-1.00.4
Patch foraging total patch changes 0 sec0.61.62.8-1.41.41.61.7-1.2-1.21.2-1.2-0.8-0.9-1.0
Patch foraging total patch changes 12 sec4.05.47.7-2.52.52.32.0-2.7-2.72.8-2.4-1.5-0.2-2.7
Patch foraging total patch changes 18 sec0.20.40.6-0.80.70.70.6-0.6-0.60.7-0.60.00.1-0.6
Patch foraging total patch changes 24 sec0.31.11.6-1.31.01.20.9-1.1-1.11.2-1.1-0.9-0.3-0.9
Patch foraging total patch changes 6 sec1.32.13.6-1.81.91.61.5-1.5-1.51.5-1.4-1.0-0.7-1.3
Patch foraging time to switch 0 sec0.00.10.3-0.20.30.20.2-0.5-0.50.3-0.4-0.20.2-0.5
Patch foraging water rate 0 sec0.00.20.2-0.40.50.50.5-0.3-0.30.4-0.4-0.3-0.5-0.1
Patch foraging water rate 12 sec0.00.10.60.3-0.80.10.20.10.1-0.2-0.1-0.1-0.20.6
Patch foraging water rate 18 sec0.30.61.0-0.70.60.70.5-1.0-1.00.9-1.0-0.60.3-0.9
Patch foraging water rate 24 sec0.40.61.3-1.01.10.90.7-0.8-0.80.7-0.8-0.5-0.2-0.6
Patch foraging water rate 6 sec1.72.43.1-1.61.41.71.6-1.6-1.61.7-1.7-1.5-0.8-1.5
Seeking ratio, delayed vs. immediate footshock0.40.53.6-0.50.10.50.70.10.10.00.1-0.8-1.90.7
Distance traveled before self-admin0.00.10.2-0.30.50.1-0.0-0.3-0.30.3-0.4-0.40.30.1
Distance traveled after self-admin0.30.50.80.8-0.6-0.8-0.90.80.8-0.70.60.40.40.9
Extensor digitorum longus weight8.734.641.56.4-6.4-5.9-5.56.46.4-6.36.15.62.85.9
Bone: elastic displacement0.00.00.20.2-0.0-0.1-0.10.10.1-0.10.20.50.1-0.2
Bone: elastic work0.10.10.3-0.40.30.1-0.1-0.3-0.30.4-0.2-0.20.3-0.6
Bone: endosteal estimation2.35.710.12.5-2.0-2.7-2.92.12.1-2.12.02.83.21.3
Bone: endosteal perimeter1.33.25.21.9-1.5-1.9-1.91.61.6-1.71.62.32.21.1
Epididymis fat weight0.10.61.50.8-0.8-0.9-1.00.50.5-0.50.50.81.20.4
Delta time in closed arm before/after self-admin4.03.75.01.9-1.9-2.2-2.21.91.9-2.12.21.71.21.6
Delta time in open arm before/after self-admin0.10.10.50.1-0.4-0.00.10.10.1-0.10.0-0.5-0.70.5
Diff in mean of infusions in LGA sessions0.00.00.1-0.0-0.20.10.1-0.3-0.30.2-0.2-0.20.2-0.2
Delay discount exponential model param0.20.20.80.4-0.4-0.5-0.40.30.3-0.30.40.90.80.2
Extinction: sum of active levers before priming1.21.93.21.5-1.8-1.5-1.51.21.2-1.41.31.41.21.0
Active lever presses in extinction session 60.50.52.1-0.60.6-0.1-0.5-0.6-0.60.7-0.7-0.51.5-0.7
Bone: final force0.40.61.2-0.80.80.30.0-0.8-0.80.8-0.9-0.21.1-1.0
Bone: final moment0.30.41.4-0.70.70.1-0.2-0.7-0.70.6-0.6-0.01.2-0.8
Food consumed during 24 hour testing period0.51.01.51.2-0.9-1.0-1.01.01.0-1.11.01.00.70.8
Glucose0.10.21.10.10.3-0.5-0.70.30.3-0.20.30.51.1-0.1
Heart weight3.35.46.52.4-2.4-2.4-2.22.42.4-2.52.52.31.52.4
Delay discount hyperbolic model param0.20.20.60.4-0.4-0.4-0.40.30.3-0.40.40.80.70.2
Intermittent access intake day 1-15 change0.00.20.6-0.20.00.40.4-0.4-0.40.3-0.5-0.8-0.5-0.4
Intermittent access intake escalation0.00.10.5-0.2-0.00.40.3-0.3-0.30.2-0.4-0.7-0.6-0.3
Intermittent access intake escalation 20.10.20.50.7-0.7-0.4-0.50.30.3-0.50.20.30.3-0.0
Intermitt. access day 1 inactive lever presses0.22.84.5-2.01.81.61.5-1.8-1.81.6-1.4-2.1-1.4-1.5
Intermitt. access day 15 inactive lever presses0.52.73.9-1.71.51.92.0-1.5-1.51.6-1.5-1.7-1.8-1.4
Intermitt. access escalation Index0.61.93.31.4-1.8-1.5-1.41.41.4-1.51.50.80.81.3
Intermittent access day 1 total infusions0.00.00.1-0.10.20.10.1-0.1-0.10.1-0.0-0.2-0.40.3
Intermittent access day 15 total infusions0.10.21.0-0.2-0.00.30.2-0.1-0.10.0-0.1-0.8-1.00.3
Intermittent access terminal intake (last 3 days)0.20.30.9-0.40.30.50.4-0.5-0.50.4-0.3-0.9-1.0-0.2
Intermittent access total infusions0.10.10.9-0.10.00.20.2-0.2-0.20.0-0.1-0.7-0.90.3
Intermittent access day 1 locomotion0.00.00.2-0.20.40.10.2-0.0-0.00.1-0.20.1-0.10.2
Intermittent access day 15 total locomotion0.00.20.4-0.20.70.30.2-0.5-0.50.4-0.50.00.2-0.6
Intermittent access total locomotion0.60.81.2-0.91.10.90.9-0.9-0.90.9-0.9-0.8-0.8-0.7
Intermittent access standard deviation0.52.53.2-1.41.31.71.5-1.8-1.81.7-1.6-1.7-1.5-1.5
Left kidney weight0.11.11.70.7-1.1-1.1-1.11.21.2-1.31.10.40.51.3
Right kidney weight0.00.21.0-0.00.1-0.4-0.7-0.3-0.30.1-0.1-0.11.0-0.4
Cocaine induced anxiety1.12.94.11.9-1.9-2.0-2.01.81.8-1.81.81.31.21.2
Post-drug Anxiety0.40.50.90.8-1.0-0.8-0.80.80.8-0.70.80.40.00.5
Baseline Anxiety1.01.62.4-1.31.31.41.6-1.3-1.31.5-1.4-0.9-1.0-0.9
Tail length0.31.42.41.3-1.5-1.1-1.11.31.3-1.31.10.70.31.3
Length with tail1.98.311.53.2-3.4-3.1-3.12.92.9-2.82.72.62.32.5
Length without tail1.78.810.63.2-3.2-3.2-3.22.92.9-2.82.83.32.82.3
Times rat made contact with spout0.50.61.4-0.51.20.60.5-1.0-1.00.8-0.9-0.20.2-1.0
Lifetime Intake0.30.31.4-0.40.30.50.6-0.4-0.40.3-0.4-1.0-1.20.2
Liver weight, left0.40.71.80.9-0.7-0.9-1.10.50.5-0.50.51.11.30.2
Liver weight, right0.40.62.2-1.11.00.60.3-0.6-0.60.5-0.4-1.5-0.9-0.4
Locomotor activity0.40.71.2-0.50.70.50.2-1.1-1.11.1-1.0-0.30.9-0.9
Locomotor testing distance1.23.04.0-1.81.81.71.6-2.0-2.02.0-1.9-1.5-0.5-1.7
Locomotor testing rearing2.59.312.1-3.53.33.43.2-2.9-2.93.0-3.0-3.1-2.4-2.6
Locomotion in novel chamber3.85.18.1-2.82.72.22.0-2.2-2.22.4-2.3-2.4-1.4-1.7
Locomotion in novel chamber post-restriction0.10.40.9-0.50.70.30.3-0.6-0.60.9-0.9-0.10.7-0.9
Fecal boli incidents, locomotor time 10.20.40.90.8-0.1-0.7-0.60.60.6-0.60.60.90.60.2
Change in fecal boli incidents, locomotor task0.00.00.1-0.1-0.30.20.0-0.3-0.30.2-0.2-0.3-0.00.0
Time >=10cm from walls, locomotor time 10.20.30.9-0.70.30.70.8-0.2-0.20.3-0.3-0.5-0.9-0.0
Bouts of movement, locomotor time 10.20.30.80.7-0.9-0.7-0.60.40.4-0.40.30.40.60.2
Total resting periods, locomotor time 10.80.91.51.2-1.1-1.1-1.20.60.6-0.70.71.01.10.4
Rest time, locomotor task time 10.10.21.00.40.0-0.2-0.3-0.0-0.00.1-0.10.71.0-0.5
Distance moved, locomotor task time 10.10.20.7-0.60.3-0.00.00.20.2-0.10.1-0.7-0.80.6
Vertical activity count, locomotor time 10.00.30.70.4-0.6-0.5-0.40.50.5-0.50.50.30.00.8
Time >=10cm from walls, locomotor time 20.30.81.3-1.10.81.00.9-1.1-1.11.1-1.2-0.60.0-0.7
Bouts of movement, locomotor time 20.20.61.2-1.10.41.11.1-0.7-0.70.7-0.7-0.8-0.6-0.4
Total resting periods, locomotor time 20.10.40.9-0.90.20.90.9-0.5-0.50.5-0.5-0.8-0.7-0.2
Rest time, locomotor task time 20.50.81.41.2-1.1-0.9-0.90.80.8-0.81.01.00.80.5
Distance moved, locomotor task time 20.20.20.5-0.1-0.0-0.7-0.60.70.7-0.60.40.10.30.7
Vertical activity count, locomotor time 20.20.50.70.7-0.6-0.8-0.50.80.8-0.80.60.50.10.9
Light reinforcement 11.04.76.1-2.32.22.22.2-2.4-2.42.5-2.2-1.9-0.9-2.3
Light reinforcement 20.30.61.3-0.81.00.3-0.0-1.0-1.00.9-0.5-0.50.5-1.1
Bone: marrow area2.25.49.42.4-2.0-2.6-2.82.02.0-2.12.02.73.11.3
Bone: maximum diameter0.00.10.5-0.20.20.0-0.1-0.2-0.20.2-0.30.20.7-0.3
Bone: maximum force0.20.31.80.3-0.3-0.6-0.70.30.3-0.30.30.61.30.1
Bone: maximum moment0.20.51.90.4-0.5-0.7-0.90.50.5-0.50.50.81.40.2
Mean time between licks in bursts0.42.74.91.8-1.6-1.6-1.61.61.6-1.51.42.21.71.3
Mean num. licks in bursts0.10.31.5-0.40.50.50.6-0.3-0.30.2-0.1-0.8-1.2-0.1
Cd content in liver1.41.62.01.4-1.4-1.4-1.21.41.4-1.41.31.20.51.1
Co content in liver1.41.72.61.5-1.3-1.2-1.01.41.4-1.41.61.0-0.31.5
Cu content in liver0.30.41.8-0.70.20.60.8-0.2-0.20.2-0.2-0.9-1.30.0
Fe content in liver1.72.13.41.5-1.2-1.8-1.81.41.4-1.41.51.51.51.0
K content in liver1.51.53.5-1.40.91.31.3-1.0-1.01.0-1.1-1.9-1.3-0.6
Mg content in liver1.71.85.7-1.40.71.51.7-0.8-0.80.8-0.8-2.1-2.4-0.3
Mn content in liver1.82.03.4-1.51.11.81.8-1.2-1.21.2-1.2-1.6-1.7-0.6
Na content in liver0.40.40.9-0.60.60.0-0.2-0.8-0.80.8-0.7-0.40.9-0.7
Rb content in liver1.41.62.1-1.41.41.41.4-1.2-1.21.2-1.1-1.1-1.2-1.3
Se content in liver8.19.612.7-3.43.03.43.3-3.1-3.13.1-3.1-3.6-2.7-2.4
Sr content in liver0.30.31.30.1-0.50.40.60.20.2-0.20.2-0.3-1.10.7
Zn content in liver3.84.56.7-2.42.32.22.2-1.9-1.92.0-2.0-2.6-2.0-1.5
Bone: minimum diameter0.61.11.70.8-0.9-1.2-1.11.11.1-1.01.01.11.30.9
Time in familiar zone, hab. session 10.30.31.9-0.10.6-0.4-0.8-0.1-0.10.3-0.30.21.4-0.4
Time in novel zone, hab. session 11.01.14.2-0.80.41.31.6-0.6-0.60.6-0.6-1.0-2.0-0.5
Total zone transitions, hab. session 11.62.23.11.7-1.5-1.6-1.51.71.7-1.61.81.20.41.5
Total locomotion distance, hab. session 10.10.10.70.2-0.10.10.30.10.1-0.20.2-0.5-0.80.3
Locomotion velocity, hab. session 10.20.30.60.8-0.8-0.4-0.20.40.4-0.60.6-0.1-0.40.6
Time in familiar zone, hab. session 20.40.50.9-0.60.60.40.1-1.0-1.00.7-0.7-0.9-0.1-0.7
Time in novel zone, hab. session 20.20.20.8-0.40.20.70.9-0.2-0.20.4-0.5-0.2-0.5-0.3
Total zone transitions, hab. session 21.21.52.11.4-1.1-1.4-1.41.11.1-1.11.31.41.00.8
Total locomotion distance, hab. session 20.40.50.80.9-0.5-0.9-0.80.30.3-0.60.60.90.90.1
Locomotion velocity, hab. session 20.50.71.31.1-0.8-1.0-1.00.60.6-0.80.81.00.90.4
Novel to familiar place preference ratio0.50.71.60.8-1.3-0.6-0.41.01.0-0.90.80.1-0.41.0
Novelty place preference0.50.61.50.7-1.2-0.4-0.21.01.0-0.80.8-0.1-0.71.0
Time in novel zone, NPP test0.30.31.00.5-1.0-0.10.10.60.6-0.40.4-0.4-0.80.7
Total zone transitions, NPP test1.11.64.11.3-0.6-1.5-1.70.60.6-0.91.11.82.00.3
Total locomotion distance, NPP test0.30.41.60.60.1-0.7-0.8-0.0-0.0-0.30.40.91.3-0.2
Locomotion velocity, NPP test0.60.81.70.9-0.2-1.1-1.20.50.5-0.90.91.31.30.3
Intraocular pressure2.64.25.52.4-1.7-2.3-2.32.22.2-2.12.22.21.01.7
Delta distance traveled before/after self-admin1.21.32.21.3-1.5-1.1-1.11.31.3-1.21.20.80.01.2
Delta ambulatory time before/after self-admin1.01.82.61.6-1.6-1.4-1.51.41.4-1.31.31.20.90.9
Parametrial fat weight0.40.91.9-0.80.80.60.5-1.1-1.11.2-1.3-0.60.7-1.4
Pavlov. Cond. lever latency1.62.14.11.5-2.0-1.0-0.71.61.6-1.71.70.7-0.71.7
Pavlov. Cond. magazine entry latency8.310.715.2-3.83.93.12.8-3.6-3.63.6-3.6-2.9-1.0-3.1
Pavlov. Cond. change in total contacts8.99.613.6-3.73.53.33.3-2.9-2.93.1-3.1-3.3-2.5-2.3
Pavlov. Cond. index score6.68.413.1-3.33.62.72.3-3.2-3.23.2-3.3-2.3-0.5-2.9
Pavlov. Cond. latency score4.96.210.1-2.83.22.21.8-2.8-2.82.8-2.9-1.9-0.1-2.6
Pavlov. Cond. lever contacts2.32.75.1-1.82.31.31.0-1.8-1.82.0-2.0-0.90.6-1.9
Pavlov. Cond. magazine entry number10.613.519.04.3-4.4-3.7-3.43.93.9-3.93.93.41.83.3
Pavlov. Cond. intertrial magazine entries1.01.32.41.4-1.5-1.0-0.71.31.3-1.31.20.8-0.11.1
Pavlov. Cond. lever-magazine prob. diff.8.110.015.4-3.63.93.02.6-3.5-3.53.5-3.5-2.6-0.7-3.2
Pavlov. Cond. response bias8.610.715.4-3.83.93.33.0-3.5-3.53.5-3.5-3.0-1.3-2.9
Pavlov. Cond. lever latency0.40.50.90.7-0.9-0.7-0.70.80.8-0.80.90.4-0.10.7
Pavlov. Cond. magazine entry latency0.10.10.20.5-0.2-0.4-0.30.10.1-0.10.20.30.30.2
Pavlov. Cond. change in total contacts0.30.81.4-0.91.21.11.2-0.7-0.70.9-0.9-0.6-0.6-0.6
Pavlov. Cond. index score0.10.10.4-0.20.60.20.2-0.4-0.40.4-0.50.00.3-0.3
Pavlov. Cond. latency score0.00.10.2-0.00.50.10.1-0.3-0.30.3-0.30.20.4-0.2
Pavlov. Cond. lever contacts0.30.51.0-0.71.00.60.6-0.8-0.80.8-0.9-0.30.3-0.7
Pavlov. Cond. magazine entry number0.00.10.20.2-0.4-0.1-0.10.20.2-0.30.30.2-0.00.1
Pavlov. Cond. intertrial magazine entries0.61.42.11.2-1.4-0.7-0.51.41.4-1.31.40.7-0.51.4
Pavlov. Cond. lever-magazine prob. diff.0.00.10.3-0.10.50.10.1-0.2-0.20.3-0.30.10.3-0.2
Pavlov. Cond. response bias0.81.11.8-1.11.40.90.9-1.2-1.21.2-1.3-0.70.0-1.0
Time in closed arm before self-admin1.32.23.3-1.61.81.81.8-1.1-1.11.3-1.3-1.6-1.6-1.1
Time in closed arm after self-admin0.20.21.2-0.20.00.20.10.50.5-0.40.5-0.4-1.10.6
Time in open arm before self-admin1.21.42.21.2-1.5-1.3-1.41.01.0-1.01.11.11.21.2
Time in open arm after self-admin0.30.30.80.7-0.9-0.6-0.50.40.4-0.40.50.30.20.7
Bone: periosteal estimation0.41.03.40.9-0.7-1.1-1.20.70.7-0.80.71.31.80.3
Bone: periosteal perimeter0.91.74.31.2-0.9-1.5-1.61.01.0-1.11.01.72.10.7
Bone: post-yield work1.11.92.61.3-1.3-1.3-1.11.51.5-1.61.51.41.11.4
Progressive ratio test 1 active lever presses0.00.10.2-0.20.20.20.2-0.1-0.10.1-0.2-0.5-0.50.1
Progressive ratio test 1 breakpoint0.00.00.2-0.10.10.10.2-0.0-0.00.0-0.1-0.4-0.40.2
Progressive ratio test 1 inactive lever presses0.20.50.9-0.80.70.70.7-0.6-0.60.4-0.4-0.9-0.9-0.3
Progressive ratio test 2 active lever presses0.70.91.2-0.90.91.11.1-1.1-1.11.0-1.1-0.9-0.7-0.7
Progressive ratio test 2 breakpoint0.81.01.2-0.91.01.11.1-1.1-1.11.0-1.1-0.9-0.7-0.7
Progressive ratio test 2 inactive lever presses0.10.20.4-0.40.50.50.4-0.6-0.60.4-0.3-0.4-0.5-0.4
Incentive Sensitization - Responses0.61.52.4-1.01.41.31.2-1.6-1.61.4-1.4-0.6-0.3-1.3
Incentive Sensitization - Breakpoint0.61.42.2-1.01.31.21.1-1.5-1.51.3-1.3-0.6-0.2-1.2
Sum of active levers in priming session hrs 5-60.00.00.2-0.3-0.1-0.0-0.2-0.2-0.2-0.0-0.0-0.50.20.0
Progressive ratio0.00.10.3-0.30.20.20.2-0.4-0.40.5-0.4-0.30.3-0.2
Food seeking constrained by brief footshock0.30.40.8-0.60.60.50.3-0.7-0.70.8-0.7-0.50.3-0.9
Seeking ratio, punishment vs. effort0.00.00.10.1-0.1-0.1-0.20.20.2-0.30.20.0-0.2-0.0
Retroperitoneal fat weight0.00.10.4-0.40.40.30.2-0.4-0.40.4-0.3-0.30.1-0.7
Reaction time number correct0.41.21.81.0-1.0-1.1-1.11.11.1-1.11.11.31.21.1
Reaction time mean minus median0.10.40.90.9-0.8-0.6-0.60.50.5-0.50.60.90.30.2
Reaction time mean minus median AUC0.00.00.20.2-0.2-0.2-0.2-0.0-0.0-0.00.10.40.0-0.1
Reaction time num false alarms0.40.61.2-0.51.10.3-0.1-1.1-1.10.8-0.60.21.0-0.9
Reaction time num false alarms AUC0.30.61.7-0.30.90.3-0.1-1.0-1.00.8-0.60.51.3-1.0
Reaction time trials correct on left0.41.21.81.0-1.0-1.1-1.11.11.1-1.11.11.31.21.1
Reaction time trials on left0.31.21.71.0-1.0-1.1-1.11.01.0-1.11.01.31.21.1
Reaction time mean0.30.82.1-0.70.21.01.1-0.7-0.70.7-0.7-1.1-1.5-0.6
Reaction time mean AUC0.30.82.4-0.70.21.01.1-0.7-0.70.7-0.7-1.2-1.5-0.6
Median of all reaction times1.42.13.7-1.40.81.61.7-1.4-1.41.3-1.3-1.9-1.9-1.1
Reaction time omissions0.40.71.2-0.90.70.80.8-1.1-1.10.9-0.7-0.7-0.6-0.8
Reaction time false alarm rate0.81.12.1-0.81.30.80.5-1.4-1.41.2-1.1-0.30.5-1.4
Reaction time premature initiation rate0.50.82.4-0.80.40.70.8-1.0-1.01.1-0.9-1.5-0.8-0.7
Reaction time premature initiations0.00.10.30.1-0.5-0.2-0.1-0.0-0.00.10.0-0.5-0.00.2
Std. dev. reaction times0.00.00.10.1-0.20.10.1-0.2-0.20.2-0.10.1-0.2-0.3
Reaction time trials completed0.31.21.71.0-1.0-1.1-1.11.01.0-1.11.01.31.21.1
Reaction time trials AUC0.31.11.71.0-1.0-1.0-1.01.01.0-1.11.01.31.11.1
Run reversals in cocaine runway, females1.41.63.81.0-1.5-0.8-0.51.41.4-1.41.40.0-1.12.0
Run reversals in cocaine runway, males0.10.10.3-0.30.40.30.4-0.3-0.30.3-0.3-0.5-0.5-0.2
Latency to leave start box in cocaine runway1.01.32.60.9-0.8-1.1-0.91.31.3-1.51.41.10.31.6
Latency to leave start box in cocaine runway, F1.51.93.31.3-1.3-1.4-1.21.51.5-1.61.51.00.41.8
Latency to leave start box in cocaine runway, M0.20.20.6-0.80.60.60.6-0.2-0.20.2-0.1-0.1-0.5-0.0
Std. dev. time between licks in bursts0.10.21.20.3-0.3-0.3-0.50.20.2-0.10.00.81.1-0.0
Total sessions with >9 infusions0.40.52.5-0.70.60.70.7-0.4-0.40.4-0.3-1.0-1.60.3
Short access day 1 total inactive lever presses1.22.44.3-1.62.11.51.4-1.6-1.61.4-1.2-1.6-1.4-1.2
Short access day 10 total inactive lever presses0.00.10.20.0-0.10.20.3-0.4-0.40.3-0.10.0-0.2-0.4
Short access day 1 total infusions0.51.03.4-1.11.00.90.7-0.5-0.50.5-0.5-1.7-1.90.4
Short access day 10 total infusions0.30.50.8-0.80.80.70.7-0.7-0.70.5-0.5-0.9-0.8-0.3
Short access total infusions0.50.71.8-0.80.70.80.8-0.6-0.60.5-0.5-1.3-1.30.1
Short access day 1 locomotion0.91.42.4-1.61.61.21.0-1.1-1.11.0-1.0-1.5-1.3-0.6
Short access day 10 total locomotion0.41.73.2-1.31.81.21.1-1.5-1.51.5-1.3-0.6-0.2-1.6
Short access total locomotion0.20.30.9-0.70.90.60.4-0.6-0.60.5-0.4-0.4-0.4-0.4
One hour access (0.3 mA shock)0.20.20.80.5-0.6-0.3-0.20.50.5-0.50.30.2-0.20.9
Compulsive drug intake0.30.52.7-0.0-0.40.20.30.60.6-0.40.3-0.2-1.61.1
One hour access (shock baseline)0.00.00.10.0-0.0-0.0-0.0-0.1-0.10.00.0-0.30.00.0
Social response proportion0.40.40.70.5-0.5-0.7-0.60.80.8-0.80.90.40.30.8
Social responses0.10.10.7-0.10.4-0.3-0.40.00.00.1-0.00.20.9-0.3
Social time0.40.63.00.4-0.2-0.8-0.90.00.0-0.00.11.01.7-0.8
Soleus weight0.30.95.40.8-0.4-0.9-1.20.20.2-0.20.11.22.3-0.3
Bone: stiffness0.00.10.4-0.0-0.1-0.2-0.30.10.1-0.20.1-0.10.60.3
Tibialis anterior weight1.65.57.22.5-2.4-2.7-2.72.42.4-2.32.32.11.82.0
Time to tail flick, vehicle, before self-admin0.20.20.90.30.2-0.2-0.3-0.1-0.10.0-0.00.90.8-0.5
Time to tail flick, vehicle, after self-admin0.10.20.90.10.1-0.0-0.1-0.2-0.20.5-0.50.41.0-0.3
Time to tail flick, test, before self-admin0.91.02.21.4-1.5-1.1-1.00.90.9-0.80.90.90.80.6
Time to tail flick, test, after self-admin0.30.31.50.10.6-0.3-0.5-0.2-0.20.20.00.91.2-0.7
Delta time to tail flick, vehicle, before/after SA0.40.41.1-0.30.50.20.2-0.7-0.70.9-0.8-0.11.0-0.8
Delta time to tail flick, test, before/after SA1.51.84.7-1.62.21.31.1-1.4-1.41.4-1.2-0.7-0.3-1.3
Tibia length1.95.48.42.2-2.0-2.8-2.92.22.2-2.32.32.32.41.6
Ambulatory time before self-admin0.00.00.1-0.10.30.10.1-0.2-0.20.1-0.3-0.3-0.10.3
Ambulatory time after self-admin1.11.72.51.6-1.2-1.5-1.61.31.3-1.31.11.01.01.2
Bone: tissue strength1.51.62.51.4-1.5-1.1-1.01.31.3-1.21.31.60.91.0
Total heroin consumption2.02.44.0-1.51.71.31.1-2.0-2.01.8-1.8-0.90.8-1.6
Bone: trabecular number4.07.510.1-3.13.12.52.1-3.2-3.23.1-3.0-2.3-0.4-2.9
Bone: trabecular spacing2.03.04.52.0-1.6-2.1-2.11.61.6-1.51.61.81.71.2
Bone: trabecular thickness0.10.20.3-0.60.50.20.1-0.4-0.40.4-0.30.20.4-0.5
Bone: trabecular tissue density0.30.53.20.0-0.60.60.80.40.4-0.30.3-0.7-1.80.7
Water consumed over 24 hours0.20.41.00.9-0.4-0.6-0.60.30.3-0.50.41.01.00.0
Number of responses in last shaping day0.40.52.2-0.70.60.80.8-0.6-0.60.5-0.4-0.7-1.5-0.3