Hub : Genes

Igfbp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Igfbp4 0.04 0.02 4.5e-05 0.04 0.04 0.04 0.04 4.1e-05 7.9e-05 9.7e-05 1.9e-05
2 Brain gene expression Igfbp4 0.33 0.11 0.0e+00 0.24 0.24 0.24 0.24 8.0e-22 7.0e-22 1.0e-21 2.5e-22
3 Brain mRNA stability Igfbp4 0.11 0.06 5.8e-09 0.1 0.1 0.09 0.1 2.2e-09 8.7e-10 2.4e-08 1.1e-09
4 pVTA gene expression Igfbp4 0.08 0.06 5.1e-03 0.04 0.04 0.03 0.03 8.0e-03 6.4e-03 1.8e-02 1.6e-02
5 OFC gene expression Igfbp4 0.57 0.18 1.2e-08 0.31 0.29 0.3 0.31 4.2e-08 1.3e-07 8.3e-08 5.0e-08
6 Adipose gene expression Igfbp4 0.55 0.14 0.0e+00 0.47 0.23 0.46 0.42 3.8e-58 7.2e-25 8.4e-57 3.1e-51
7 Adipose mRNA stability Igfbp4 0.37 0.16 0.0e+00 0.22 0.17 0.22 0.22 2.1e-24 1.4e-18 8.1e-24 5.8e-24
8 NAcc mRNA stability Igfbp4 0.03 0.02 9.5e-04 0.02 0.03 0.02 0.02 1.9e-03 5.7e-04 1.5e-03 7.3e-04
9 PL gene expression Igfbp4 0.05 0.03 3.4e-07 0.06 0.06 0.04 0.05 1.5e-07 4.9e-07 2.0e-05 2.6e-06
10 Liver mRNA stability Igfbp4 0.15 0.12 1.8e-07 0.05 0.06 0.02 0.04 2.6e-06 9.8e-07 5.9e-03 1.2e-05
11 NAcc gene expression Igfbp4 0.03 0.02 7.2e-03 0 -0 0 0 1.8e-01 5.1e-01 1.7e-01 1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.23.65.02.2-1.61.92.12.0-2.1-2.12.21.72.10.1
Area under the delay curve0.20.20.70.5-0.50.50.50.4-0.3-0.30.50.10.10.8
BMI with tail2.37.511.3-2.63.4-3.3-2.9-2.92.82.8-2.4-3.0-1.3-2.1
BMI without tail0.20.41.2-0.50.5-0.6-0.6-0.60.60.6-0.6-1.1-0.4-0.4
Body weight4.518.727.6-4.55.3-5.1-4.6-4.64.64.6-3.8-4.6-2.1-2.8
Weight adjusted by age0.30.31.70.10.6-0.6-0.2-0.20.20.20.2-0.00.7-1.3
Bone surface0.20.31.40.50.4-0.10.20.1-0.1-0.10.6-0.31.2-1.1
Bone volume0.40.62.60.70.30.00.40.4-0.5-0.50.9-0.21.6-1.4
Breakpoint value in progressive ratio session0.20.20.40.5-0.30.40.50.4-0.5-0.50.50.60.5-0.2
Number of licking bursts0.40.41.90.40.20.10.30.6-0.4-0.40.6-0.01.3-1.4
Context. condit. distance diff. score1.82.15.4-1.30.6-0.8-1.2-1.61.61.6-1.5-0.3-2.31.9
Locomotion velocity, session 10.40.40.9-0.60.9-0.9-0.6-0.60.50.5-0.3-0.90.2-0.9
Locomotion distance, session 12.12.74.7-1.72.2-2.0-1.6-1.51.41.4-1.2-2.1-0.1-1.7
Locomotion velocity, session 20.00.00.1-0.10.1-0.2-0.2-0.30.30.3-0.20.1-0.20.0
Locomotion distance, session 20.40.52.7-0.20.8-0.7-0.2-0.0-0.0-0.00.2-0.71.0-1.6
Locomotion velocity, session 30.20.20.90.3-0.70.60.40.3-0.2-0.20.20.9-0.10.6
Locomotion distance, session 30.10.10.2-0.40.3-0.3-0.4-0.30.40.4-0.4-0.2-0.1-0.3
Stereotopy head waving bouts, day 32.22.63.71.9-1.81.91.81.5-1.5-1.51.71.60.71.5
Stereotopy head waving duration, day 30.10.10.50.6-0.20.40.40.1-0.1-0.10.50.3-0.00.7
Locomotion velocity, session 71.11.32.3-1.01.4-1.2-1.1-0.81.21.2-0.9-1.2-0.0-1.5
Locomotion distance, session 70.50.71.0-1.00.8-0.8-0.9-0.60.80.8-1.0-0.9-0.3-1.0
Stereotopy head waving bouts, day 70.50.51.11.0-0.60.60.90.7-0.7-0.71.10.60.80.3
Stereotopy head waving duration, day 70.40.41.00.9-0.50.50.80.6-0.5-0.51.00.50.70.4
Locomotion velocity, session 86.78.09.9-3.12.8-3.0-3.1-3.13.13.1-3.0-2.5-2.8-0.1
Locomotion distance, session 81.01.42.1-1.31.4-1.4-1.3-1.41.31.3-1.1-1.0-0.8-0.3
Degree of sensitization distance1.51.52.1-1.41.2-1.2-1.4-1.21.21.2-1.4-1.2-1.1-0.4
Degree of sensitization stereotypy0.70.81.41.1-0.60.71.01.0-1.0-1.01.20.71.0-0.0
Conditioned locomotion0.30.30.70.6-0.70.70.60.5-0.4-0.40.50.40.20.8
Cocaine response after cond. corrected0.70.82.21.0-0.00.20.80.9-0.9-0.91.30.11.5-0.9
Cocaine response after cond. not corrected0.91.02.81.2-0.10.40.91.0-1.1-1.11.40.21.7-1.0
Cocaine response before conditioning0.10.10.20.4-0.50.50.30.2-0.3-0.30.10.40.00.3
Saline control response0.30.40.9-0.30.9-0.8-0.5-0.50.60.6-0.1-0.90.3-0.8
Bone: connectivity density3.35.27.02.6-2.12.42.52.3-2.5-2.52.52.12.20.4
Bone: cortical apparent density5.06.710.52.6-3.23.12.72.6-2.6-2.62.13.10.91.9
Bone: cortical area0.10.10.30.3-0.20.30.30.2-0.2-0.20.30.60.30.0
Bone: cortical porosity0.20.31.00.50.4-0.00.40.4-0.2-0.20.7-0.11.0-0.7
Bone: cortical porosity0.30.31.00.40.6-0.30.20.2-0.1-0.10.7-0.41.0-0.9
Bone: cortical thickness1.11.73.11.4-1.61.51.41.1-1.2-1.21.21.80.41.4
Bone: cortical thickness5.96.99.33.1-2.92.92.92.6-2.5-2.52.82.71.62.1
Bone: cortical tissue density5.06.610.42.6-3.23.12.72.6-2.6-2.62.13.10.91.9
Condit. Reinf. active minus inactive responses1.21.42.51.1-1.51.41.21.1-1.1-1.10.91.60.11.3
Condit. Reinf. active-inactive response ratio1.71.83.31.1-1.81.71.31.1-1.1-1.10.91.8-0.01.8
Condit. Reinf. active responses1.11.43.01.1-1.41.31.11.1-1.1-1.10.91.70.21.0
Condit. Reinf. inactive responses0.10.20.30.4-0.10.10.20.4-0.4-0.40.40.50.5-0.6
Incentive salience index mean1.92.43.61.5-1.81.81.61.6-1.6-1.61.41.90.90.8
Condit. Reinf. lever presses0.81.11.31.1-1.01.11.01.1-1.1-1.11.01.11.1-0.2
Condit. Reinf. active minus inactive responses1.11.42.11.2-1.11.21.21.4-1.4-1.41.20.81.4-0.5
Condit. Reinf. active-inactive response ratio1.01.02.00.9-0.70.81.01.2-1.2-1.21.00.41.4-0.9
Condit. Reinf. active responses1.92.64.21.7-1.21.41.61.9-1.8-1.81.71.22.1-0.9
Condit. Reinf. inactive responses1.92.33.21.7-1.11.31.61.7-1.6-1.61.71.41.8-0.5
Condit. Reinf. lever presses0.20.30.50.6-0.50.60.60.5-0.4-0.40.50.70.40.3
Condit. Reinf. lever reinforcers received1.92.73.71.8-1.41.61.71.9-1.8-1.81.81.41.9-0.4
Conditioned reinforcement - actives0.50.50.80.4-0.80.90.80.9-0.7-0.70.60.70.50.2
Conditioned reinforcement - inactives1.51.73.31.0-1.81.61.31.3-1.7-1.70.91.20.40.7
Conditioned locomotion0.30.40.90.2-0.50.60.70.8-0.6-0.60.60.21.0-0.7
Patch foraging indifference point 0 sec1.72.74.71.4-2.12.11.71.6-1.6-1.61.22.20.80.9
Patch foraging indifference point AUC0.00.00.10.10.2-0.2-0.20.10.00.0-0.00.00.2-0.4
Delay disc. indifference point, 0s delay1.01.12.31.2-1.01.11.11.0-0.9-0.91.11.50.90.4
Delay disc. indifference point, 16s delay0.80.85.60.9-0.90.80.60.2-0.2-0.20.50.4-0.72.4
Delay disc. indifference point, 2s delay0.70.81.70.9-0.60.70.91.0-0.9-0.91.10.51.3-0.5
Delay disc. indifference point, 24s delay0.20.20.4-0.5-0.0-0.1-0.3-0.30.40.4-0.5-0.5-0.60.5
Delay disc. indifference point, 4s delay0.90.91.71.3-0.70.91.11.0-0.9-0.91.30.80.80.7
Delay disc. indifference point, 8s delay0.00.00.10.0-0.20.30.30.3-0.2-0.20.20.10.20.1
Indifference point function ln k0.20.31.6-0.2-0.40.30.1-0.40.30.3-0.20.2-0.81.2
Indifference point function log k0.20.31.6-0.2-0.40.30.1-0.40.30.3-0.20.2-0.81.2
Patch foraging total patch changes 0 sec1.21.93.51.1-1.81.81.41.3-1.4-1.40.91.90.70.7
Patch foraging total patch changes 12 sec5.26.88.82.6-2.52.72.83.0-2.9-2.92.72.32.9-0.4
Patch foraging total patch changes 18 sec0.50.71.10.8-0.91.00.80.9-0.9-0.90.60.90.9-0.3
Patch foraging total patch changes 24 sec1.61.92.41.5-1.31.51.51.5-1.4-1.41.41.51.40.3
Patch foraging total patch changes 6 sec1.82.73.81.8-1.81.91.81.8-1.7-1.71.51.91.30.4
Patch foraging time to switch 0 sec0.10.20.40.3-0.30.30.40.5-0.4-0.40.50.10.6-0.3
Patch foraging water rate 0 sec0.10.10.50.4-0.40.40.30.2-0.3-0.30.10.7-0.00.4
Patch foraging water rate 12 sec0.00.00.1-0.2-0.10.20.1-0.10.10.10.00.3-0.10.4
Patch foraging water rate 18 sec0.60.82.01.1-0.40.81.00.8-0.8-0.81.30.51.4-0.3
Patch foraging water rate 24 sec0.50.71.00.9-0.91.01.00.8-0.8-0.80.90.70.80.2
Patch foraging water rate 6 sec1.72.53.11.8-1.61.71.81.7-1.7-1.71.71.31.40.5
Seeking ratio, delayed vs. immediate footshock1.01.15.20.4-1.30.90.50.4-0.4-0.40.01.5-1.22.3
Distance traveled before self-admin0.10.10.40.40.4-0.2-0.0-0.10.10.10.2-0.10.4-0.6
Distance traveled after self-admin1.21.32.0-1.01.4-1.3-1.2-1.21.31.3-1.0-1.2-0.8-0.4
Extensor digitorum longus weight8.332.741.5-6.45.7-5.9-6.3-6.36.26.2-6.2-5.5-5.0-1.2
Bone: elastic displacement0.00.00.2-0.4-0.1-0.0-0.2-0.10.00.0-0.40.2-0.3-0.1
Bone: elastic work0.10.20.40.5-0.20.20.40.3-0.4-0.40.60.40.6-0.2
Bone: endosteal estimation2.24.98.3-2.02.9-2.6-2.2-2.12.12.1-1.6-2.7-0.1-2.5
Bone: endosteal perimeter1.32.63.6-1.81.9-1.8-1.7-1.61.61.6-1.5-1.7-0.5-1.7
Epididymis fat weight0.10.21.0-0.20.4-0.3-0.1-0.10.10.10.0-0.10.6-1.0
Delta time in closed arm before/after self-admin3.13.04.4-1.61.9-2.1-2.0-1.91.81.8-1.8-1.7-1.4-0.5
Delta time in open arm before/after self-admin0.10.10.30.00.0-0.0-0.1-0.20.10.1-0.1-0.0-0.50.6
Diff in mean of infusions in LGA sessions0.10.10.40.0-0.10.20.30.3-0.3-0.30.40.70.4-0.3
Delay discount exponential model param0.10.10.7-0.30.3-0.3-0.3-0.20.10.1-0.40.10.1-0.8
Extinction: sum of active levers before priming1.61.62.5-1.21.6-1.5-1.4-1.41.21.2-1.2-1.2-0.5-1.2
Active lever presses in extinction session 62.72.77.92.0-0.30.71.51.3-1.2-1.22.31.22.8-1.7
Bone: final force0.71.13.91.2-0.10.40.90.8-0.8-0.81.40.32.0-1.2
Bone: final moment0.50.83.21.00.10.20.70.6-0.7-0.71.10.11.8-1.3
Food consumed during 24 hour testing period0.80.91.3-1.11.1-1.1-1.0-1.01.11.1-0.9-0.9-0.6-0.4
Glucose0.00.10.20.40.2-0.00.10.00.00.00.3-0.20.5-0.1
Heart weight3.85.47.1-2.42.3-2.4-2.5-2.72.52.5-2.5-2.4-2.1-0.4
Delay discount hyperbolic model param0.20.20.6-0.50.4-0.4-0.5-0.30.20.2-0.5-0.2-0.1-0.8
Intermittent access intake day 1-15 change0.70.70.90.9-0.90.90.90.7-0.8-0.80.80.80.40.7
Intermittent access intake escalation0.70.70.90.9-0.80.91.00.7-0.8-0.80.90.90.40.7
Intermittent access intake escalation 20.00.00.10.1-0.20.10.20.1-0.3-0.30.30.00.2-0.1
Intermitt. access day 1 inactive lever presses2.72.94.52.1-1.71.61.91.6-1.8-1.82.11.61.40.9
Intermitt. access day 15 inactive lever presses4.34.75.92.3-2.42.42.42.3-2.3-2.32.22.31.31.3
Intermitt. access escalation Index1.51.42.2-1.01.4-1.4-1.2-1.51.41.4-0.8-1.1-0.6-0.3
Intermittent access day 1 total infusions0.20.20.30.4-0.50.30.50.5-0.5-0.50.50.20.5-0.1
Intermittent access day 15 total infusions0.91.01.31.1-1.11.01.10.9-1.0-1.01.10.90.31.2
Intermittent access terminal intake (last 3 days)0.90.91.31.1-1.11.01.11.0-1.1-1.11.10.70.60.7
Intermittent access total infusions0.30.40.50.7-0.70.50.60.5-0.7-0.70.70.30.20.6
Intermittent access day 1 locomotion0.10.10.20.2-0.50.40.30.4-0.4-0.40.10.30.2-0.0
Intermittent access day 15 total locomotion0.20.20.3-0.1-0.60.40.30.5-0.6-0.60.1-0.00.4-0.5
Intermittent access total locomotion0.60.61.10.6-1.01.00.91.0-0.9-0.90.50.70.40.3
Intermittent access standard deviation2.83.04.61.6-2.11.91.71.9-2.0-2.01.51.80.71.2
Left kidney weight0.61.73.2-1.01.4-1.2-1.2-1.71.81.8-1.1-0.5-1.40.9
Right kidney weight0.10.20.50.10.7-0.7-0.2-0.50.40.40.3-0.50.4-0.3
Cocaine induced anxiety1.72.03.6-1.01.9-1.9-1.3-1.51.41.4-0.6-1.7-0.0-1.5
Post-drug Anxiety0.20.20.5-0.00.7-0.7-0.4-0.50.50.5-0.0-0.5-0.0-0.4
Baseline Anxiety1.11.22.00.9-1.41.40.91.1-1.0-1.00.41.4-0.21.3
Tail length0.10.30.5-0.60.2-0.4-0.4-0.50.70.7-0.5-0.7-0.60.5
Length with tail1.76.28.6-2.72.8-2.7-2.6-2.92.92.9-2.3-2.2-1.8-0.4
Length without tail2.45.39.7-2.33.1-2.8-2.4-2.62.62.6-1.7-2.0-0.8-1.4
Times rat made contact with spout0.50.50.80.7-0.70.70.70.9-0.9-0.90.70.40.8-0.6
Lifetime Intake0.50.60.80.9-0.80.70.80.7-0.8-0.80.80.50.30.8
Liver weight, left0.10.10.20.3-0.30.30.30.5-0.2-0.20.30.00.4-0.1
Liver weight, right0.91.43.31.7-1.01.01.41.0-1.0-1.01.80.71.30.9
Locomotor activity0.81.23.41.0-0.50.61.01.2-1.1-1.11.40.51.8-1.1
Locomotor testing distance2.13.44.71.9-1.81.82.02.2-2.0-2.01.91.91.9-0.1
Locomotor testing rearing6.09.312.63.3-3.63.53.43.2-3.1-3.13.03.22.01.7
Locomotion in novel chamber4.55.69.23.0-2.32.42.72.5-2.4-2.42.72.21.90.7
Locomotion in novel chamber post-restriction1.01.22.51.1-0.30.61.01.3-1.0-1.01.20.61.6-1.5
Fecal boli incidents, locomotor time 10.60.71.3-0.90.7-0.9-0.9-0.60.70.7-1.0-1.1-0.6-0.9
Change in fecal boli incidents, locomotor task0.00.00.1-0.20.1-0.1-0.0-0.20.10.10.10.00.10.3
Time >=10cm from walls, locomotor time 10.30.31.30.3-0.70.60.30.3-0.3-0.30.01.1-0.40.9
Bouts of movement, locomotor time 10.20.20.4-0.20.7-0.6-0.5-0.40.40.4-0.3-0.4-0.0-0.6
Total resting periods, locomotor time 10.70.81.4-0.71.1-1.2-1.0-0.70.70.7-0.7-1.1-0.2-1.1
Rest time, locomotor task time 10.20.21.4-0.10.2-0.10.00.1-0.1-0.10.1-0.80.7-1.2
Distance moved, locomotor task time 10.20.20.90.5-0.20.10.20.1-0.0-0.00.30.7-0.30.9
Vertical activity count, locomotor time 10.10.10.2-0.30.3-0.4-0.3-0.40.30.3-0.3-0.3-0.40.3
Time >=10cm from walls, locomotor time 21.21.31.91.1-1.01.11.21.2-1.2-1.21.21.41.4-0.2
Bouts of movement, locomotor time 20.60.71.81.0-0.81.00.80.6-0.6-0.60.71.30.50.7
Total resting periods, locomotor time 20.50.51.70.8-0.80.90.70.5-0.4-0.40.51.30.30.8
Rest time, locomotor task time 20.70.81.3-1.10.9-0.9-0.9-0.80.80.8-0.9-1.1-0.4-0.7
Distance moved, locomotor task time 20.10.20.50.00.7-0.5-0.3-0.50.50.5-0.0-0.2-0.1-0.0
Vertical activity count, locomotor time 20.40.51.1-0.60.7-0.7-0.6-0.70.60.6-0.6-1.0-0.70.2
Light reinforcement 13.15.67.22.5-2.62.52.62.6-2.7-2.72.41.92.10.4
Light reinforcement 20.60.82.00.9-0.40.30.80.9-1.0-1.01.20.11.4-0.7
Bone: marrow area2.14.67.8-2.02.8-2.5-2.1-2.02.02.0-1.6-2.6-0.1-2.4
Bone: maximum diameter0.10.10.50.30.00.10.20.3-0.2-0.20.40.30.7-0.6
Bone: maximum force0.20.31.20.10.8-0.4-0.1-0.30.30.30.3-0.40.9-1.1
Bone: maximum moment0.20.41.2-0.10.9-0.6-0.4-0.50.40.40.0-0.60.7-1.1
Mean time between licks in bursts1.31.82.5-1.61.4-1.3-1.5-1.31.21.2-1.5-1.4-0.6-1.5
Mean num. licks in bursts0.20.21.00.2-0.60.30.20.1-0.2-0.2-0.00.3-0.71.0
Cd content in liver0.10.10.20.4-0.10.30.30.1-0.2-0.20.40.20.00.4
Co content in liver0.60.72.1-0.90.4-0.7-0.9-0.80.70.7-1.1-0.5-1.50.7
Cu content in liver0.20.31.40.1-0.50.30.10.00.00.0-0.10.7-0.81.2
Fe content in liver0.70.91.7-0.81.3-1.2-0.9-0.91.01.0-0.6-1.2-0.2-0.6
K content in liver2.22.13.21.7-1.41.41.61.4-1.5-1.51.81.31.40.7
Mg content in liver2.32.45.01.5-2.01.71.51.2-1.3-1.31.21.90.12.2
Mn content in liver3.23.75.32.0-2.32.22.11.8-1.9-1.91.92.21.11.5
Na content in liver0.80.82.81.10.00.20.70.8-0.7-0.71.2-0.21.7-1.0
Rb content in liver1.21.52.31.3-1.51.41.31.3-1.3-1.31.01.50.50.7
Se content in liver5.97.29.53.1-3.02.93.02.8-2.7-2.72.82.71.81.5
Sr content in liver0.30.30.80.1-0.80.70.40.3-0.3-0.30.10.7-0.30.9
Zn content in liver2.83.14.01.8-1.91.91.92.0-2.0-2.01.81.71.20.7
Bone: minimum diameter0.40.81.4-0.81.2-1.1-0.9-1.01.01.0-0.6-0.8-0.1-0.8
Time in familiar zone, hab. session 10.60.62.50.70.5-0.20.40.3-0.2-0.21.0-0.71.6-1.2
Time in novel zone, hab. session 11.01.02.90.3-1.41.20.50.6-0.6-0.6-0.21.7-1.01.5
Total zone transitions, hab. session 11.62.22.9-1.71.4-1.6-1.6-1.61.71.7-1.6-1.2-1.50.0
Total locomotion distance, hab. session 10.10.10.9-0.1-0.20.10.0-0.20.20.2-0.10.3-0.60.9
Locomotion velocity, hab. session 10.20.20.4-0.50.3-0.4-0.4-0.60.50.5-0.3-0.2-0.70.7
Time in familiar zone, hab. session 20.50.51.31.1-0.20.40.80.7-0.8-0.81.10.10.90.1
Time in novel zone, hab. session 20.30.31.00.2-0.80.70.40.5-0.4-0.40.01.00.00.2
Total zone transitions, hab. session 21.11.42.2-1.51.3-1.4-1.3-1.21.01.0-1.3-1.4-0.8-0.7
Total locomotion distance, hab. session 20.40.51.0-0.90.9-0.9-0.7-0.60.30.3-0.6-1.0-0.2-0.8
Locomotion velocity, hab. session 20.50.71.4-1.01.0-1.1-0.9-0.80.50.5-0.7-1.2-0.3-0.8
Novel to familiar place preference ratio0.60.61.1-0.60.4-0.6-0.7-0.91.01.0-0.8-0.3-1.10.8
Novelty place preference0.60.61.4-0.60.2-0.4-0.6-0.80.90.9-0.8-0.1-1.21.1
Time in novel zone, NPP test0.30.31.3-0.2-0.1-0.1-0.2-0.40.60.6-0.40.2-0.91.1
Total zone transitions, NPP test1.01.43.0-1.31.5-1.4-1.2-0.90.80.8-0.8-1.70.2-1.7
Total locomotion distance, NPP test0.20.31.4-0.50.7-0.6-0.4-0.30.00.0-0.1-0.80.5-1.2
Locomotion velocity, NPP test0.60.81.6-1.11.1-1.1-0.9-0.90.60.6-0.7-1.3-0.1-1.1
Intraocular pressure3.44.76.3-2.52.0-2.3-2.4-2.02.22.2-2.5-2.5-2.1-0.8
Delta distance traveled before/after self-admin1.41.52.1-1.51.1-1.2-1.3-1.21.31.3-1.3-1.3-1.30.3
Delta ambulatory time before/after self-admin1.11.22.3-1.31.2-1.2-1.2-1.01.11.1-1.0-1.5-0.7-0.4
Parametrial fat weight1.83.55.52.3-1.41.72.02.2-1.9-1.92.31.32.3-0.7
Pavlov. Cond. lever latency2.32.95.7-1.91.1-1.3-1.7-1.91.81.8-2.0-1.1-2.41.2
Pavlov. Cond. magazine entry latency8.410.814.13.8-3.03.23.63.6-3.6-3.63.72.93.30.1
Pavlov. Cond. change in total contacts7.78.210.73.2-3.23.33.23.0-2.8-2.82.93.21.81.7
Pavlov. Cond. index score6.38.010.33.2-2.52.73.13.2-3.1-3.13.22.33.2-0.6
Pavlov. Cond. latency score4.76.08.72.7-2.02.22.62.8-2.7-2.72.81.83.0-0.8
Pavlov. Cond. lever contacts1.82.14.61.5-0.81.01.41.7-1.5-1.51.70.92.1-1.3
Pavlov. Cond. magazine entry number9.812.115.6-3.93.4-3.6-3.8-3.83.83.8-3.8-3.2-3.2-0.5
Pavlov. Cond. intertrial magazine entries1.21.42.5-1.40.8-1.0-1.3-1.31.31.3-1.5-0.8-1.60.4
Pavlov. Cond. lever-magazine prob. diff.7.18.811.13.3-2.72.93.23.3-3.3-3.33.32.63.1-0.3
Pavlov. Cond. response bias7.69.211.93.4-3.03.13.33.3-3.2-3.23.32.92.80.5
Pavlov. Cond. lever latency0.40.50.7-0.80.6-0.7-0.7-0.80.70.7-0.7-0.8-0.80.3
Pavlov. Cond. magazine entry latency0.10.10.2-0.30.3-0.4-0.3-0.10.20.2-0.2-0.3-0.0-0.4
Pavlov. Cond. change in total contacts0.60.81.40.9-1.11.10.91.0-0.7-0.70.71.20.50.3
Pavlov. Cond. index score0.10.20.30.4-0.20.30.40.5-0.4-0.40.40.20.6-0.5
Pavlov. Cond. latency score0.10.10.30.2-0.10.10.20.3-0.2-0.20.20.10.5-0.6
Pavlov. Cond. lever contacts0.71.01.81.1-0.60.81.01.1-1.0-1.01.10.91.3-0.6
Pavlov. Cond. magazine entry number0.00.00.0-0.2-0.00.0-0.1-0.10.10.1-0.2-0.0-0.20.2
Pavlov. Cond. intertrial magazine entries1.11.42.9-1.40.4-0.7-1.2-1.31.31.3-1.5-0.4-1.71.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.3-0.10.10.20.3-0.2-0.20.30.10.4-0.5
Pavlov. Cond. response bias1.01.41.91.4-0.91.01.21.3-1.3-1.31.31.11.4-0.4
Time in closed arm before self-admin0.80.92.10.9-1.31.41.10.8-0.6-0.60.70.60.21.5
Time in closed arm after self-admin0.70.72.8-0.30.1-0.2-0.6-0.80.90.9-0.8-0.4-1.31.7
Time in open arm before self-admin1.01.11.8-1.31.3-1.4-1.2-1.01.01.0-0.9-0.6-0.4-0.9
Time in open arm after self-admin0.40.40.8-0.90.6-0.8-0.8-0.50.50.5-0.7-0.5-0.6-0.4
Bone: periosteal estimation0.40.72.0-0.61.2-1.0-0.7-0.70.70.7-0.3-0.90.5-1.4
Bone: periosteal perimeter0.81.32.5-1.11.5-1.3-1.1-1.01.11.1-0.8-1.20.1-1.6
Bone: post-yield work1.52.02.8-1.51.6-1.4-1.5-1.71.61.6-1.4-1.3-0.8-0.6
Progressive ratio test 1 active lever presses0.50.50.80.9-0.80.80.80.6-0.7-0.70.70.60.30.7
Progressive ratio test 1 breakpoint0.40.40.70.8-0.70.70.70.6-0.6-0.60.70.50.30.7
Progressive ratio test 1 inactive lever presses2.02.23.01.7-1.61.61.61.3-1.5-1.51.51.50.81.3
Progressive ratio test 2 active lever presses1.21.22.01.0-1.41.31.21.2-1.3-1.30.91.00.60.6
Progressive ratio test 2 breakpoint0.80.91.50.8-1.21.11.01.0-1.1-1.10.80.90.40.6
Progressive ratio test 2 inactive lever presses0.60.71.20.7-1.10.90.80.8-1.1-1.10.70.70.40.5
Incentive Sensitization - Responses1.01.01.90.5-1.41.11.01.2-1.4-1.40.60.80.7-0.3
Incentive Sensitization - Breakpoint0.90.91.70.5-1.31.11.01.1-1.3-1.30.70.70.8-0.4
Sum of active levers in priming session hrs 5-60.50.51.30.9-0.30.50.80.4-0.6-0.61.10.61.00.0
Progressive ratio0.30.31.00.7-0.20.30.40.6-0.6-0.60.6-0.01.0-0.8
Food seeking constrained by brief footshock0.30.41.30.5-0.30.40.70.6-0.6-0.60.9-0.11.1-0.6
Seeking ratio, punishment vs. effort0.10.10.2-0.40.0-0.1-0.1-0.30.20.2-0.2-0.0-0.40.4
Retroperitoneal fat weight0.00.10.50.00.5-0.4-0.2-0.40.30.3-0.0-0.70.2-0.3
Reaction time number correct0.60.91.4-1.01.2-1.1-1.0-1.00.90.9-0.9-0.9-0.4-0.8
Reaction time mean minus median0.40.51.1-1.00.3-0.6-0.8-0.50.40.4-1.0-0.8-0.8-0.5
Reaction time mean minus median AUC0.10.10.3-0.4-0.1-0.2-0.4-0.1-0.1-0.1-0.6-0.3-0.4-0.3
Reaction time num false alarms0.60.82.30.8-0.30.40.60.8-1.1-1.10.90.01.5-1.2
Reaction time num false alarms AUC0.60.82.40.6-0.20.40.60.8-1.0-1.00.70.11.6-1.5
Reaction time trials correct on left0.60.91.4-1.01.2-1.1-1.0-1.00.90.9-0.9-0.9-0.4-0.8
Reaction time trials on left0.60.91.3-1.01.1-1.1-1.0-1.00.90.9-0.9-0.9-0.4-0.8
Reaction time mean0.40.51.40.5-1.10.90.70.6-0.7-0.70.40.7-0.31.2
Reaction time mean AUC0.40.61.70.5-1.10.90.70.6-0.7-0.70.40.7-0.31.3
Median of all reaction times1.31.72.91.2-1.71.61.41.2-1.3-1.31.11.30.31.5
Reaction time omissions1.01.42.41.1-1.11.11.21.3-1.6-1.61.20.71.00.1
Reaction time false alarm rate0.81.22.41.1-0.70.81.01.1-1.3-1.31.10.51.5-0.9
Reaction time premature initiation rate0.81.02.31.3-0.60.81.21.1-0.9-0.91.50.80.90.7
Reaction time premature initiations0.10.10.40.40.3-0.00.30.2-0.0-0.00.70.10.30.3
Std. dev. reaction times0.00.00.1-0.3-0.2-0.0-0.20.0-0.1-0.1-0.4-0.1-0.4-0.1
Reaction time trials completed0.60.91.3-1.01.1-1.1-1.0-1.00.90.9-0.9-0.9-0.4-0.8
Reaction time trials AUC0.50.81.1-1.01.0-0.9-1.0-0.90.90.9-0.9-0.7-0.5-0.7
Run reversals in cocaine runway, females2.42.45.3-1.41.2-1.0-1.3-1.61.61.6-1.4-0.5-2.32.1
Run reversals in cocaine runway, males0.20.20.30.3-0.60.50.50.5-0.5-0.50.50.50.00.5
Latency to leave start box in cocaine runway1.31.42.2-1.01.1-1.2-1.3-1.51.41.4-1.3-0.6-1.30.3
Latency to leave start box in cocaine runway, F1.11.21.9-0.91.2-1.3-1.3-1.41.31.3-1.0-0.6-1.10.0
Latency to leave start box in cocaine runway, M0.30.31.10.4-0.70.70.40.1-0.1-0.10.11.0-0.31.0
Std. dev. time between licks in bursts0.10.21.2-0.10.3-0.2-0.2-0.1-0.0-0.0-0.1-0.30.5-1.1
Total sessions with >9 infusions0.91.02.41.1-1.11.11.00.7-0.9-0.90.81.00.11.5
Short access day 1 total inactive lever presses2.32.53.81.6-2.01.61.71.7-1.9-1.91.51.40.91.0
Short access day 10 total inactive lever presses0.00.00.0-0.1-0.0-0.10.0-0.1-0.2-0.20.2-0.00.00.2
Short access day 1 total infusions1.31.43.11.5-1.21.21.21.0-1.0-1.01.21.20.31.8
Short access day 10 total infusions0.40.50.80.8-0.70.60.80.7-0.8-0.80.90.30.8-0.0
Short access total infusions0.80.92.21.2-1.00.91.00.7-0.8-0.81.00.90.21.5
Short access day 1 locomotion4.04.35.52.3-2.42.22.22.1-2.2-2.22.12.11.51.1
Short access day 10 total locomotion0.91.01.60.7-1.21.01.01.3-1.2-1.20.80.71.1-0.6
Short access total locomotion0.60.61.10.6-1.10.90.70.7-0.8-0.80.40.80.10.9
One hour access (0.3 mA shock)0.00.00.30.1-0.20.20.20.2-0.1-0.10.00.1-0.20.5
Compulsive drug intake0.90.93.3-0.90.3-0.2-0.8-0.60.70.7-1.4-0.0-1.81.4
One hour access (shock baseline)0.50.51.20.9-0.60.50.80.7-0.7-0.71.10.31.0-0.2
Social response proportion0.40.50.8-0.60.7-0.7-0.7-0.90.90.9-0.6-0.6-0.50.0
Social responses0.10.10.60.20.3-0.20.10.1-0.0-0.00.4-0.30.8-0.7
Social time0.50.74.4-0.50.8-0.9-0.4-0.0-0.1-0.1-0.1-1.00.8-2.1
Soleus weight0.31.04.9-0.21.1-0.8-0.3-0.30.10.10.2-1.51.3-2.2
Bone: stiffness0.10.20.60.40.5-0.20.1-0.20.20.20.5-0.30.8-0.4
Tibialis anterior weight1.44.77.7-2.22.6-2.6-2.3-2.32.22.2-1.8-2.8-1.1-1.2
Time to tail flick, vehicle, before self-admin0.10.10.3-0.50.1-0.2-0.3-0.10.10.1-0.5-0.2-0.2-0.6
Time to tail flick, vehicle, after self-admin0.10.11.1-0.10.1-0.10.00.3-0.1-0.10.1-0.20.5-1.1
Time to tail flick, test, before self-admin1.31.32.4-1.61.1-1.2-1.2-1.01.11.1-1.2-1.4-0.9-0.5
Time to tail flick, test, after self-admin0.10.11.2-0.20.2-0.3-0.20.0-0.1-0.1-0.1-0.20.3-1.1
Delta time to tail flick, vehicle, before/after SA0.60.62.80.40.10.10.50.7-0.5-0.50.8-0.01.5-1.7
Delta time to tail flick, test, before/after SA1.31.21.61.2-1.11.11.11.2-1.3-1.31.01.11.0-0.1
Tibia length1.74.98.4-1.92.9-2.8-2.3-2.32.12.1-1.6-2.8-0.7-1.8
Ambulatory time before self-admin0.00.00.10.00.3-0.2-0.2-0.20.20.2-0.20.1-0.2-0.1
Ambulatory time after self-admin2.22.43.9-1.42.0-1.8-1.6-1.61.61.6-1.3-2.0-0.9-0.9
Bone: tissue strength1.11.11.8-1.30.9-0.9-1.2-1.11.01.0-1.3-0.9-0.8-0.6
Total heroin consumption2.52.96.71.6-1.01.31.71.6-1.8-1.82.01.22.6-1.7
Bone: trabecular number4.87.610.53.2-2.32.63.02.9-3.1-3.13.22.13.1-0.1
Bone: trabecular spacing2.02.64.2-1.62.0-2.1-1.7-1.51.41.4-1.3-2.0-0.6-1.5
Bone: trabecular thickness0.10.10.30.3-0.40.40.30.3-0.5-0.50.30.30.5-0.2
Bone: trabecular tissue density0.40.63.0-0.3-0.80.5-0.0-0.20.30.3-0.50.8-1.31.7
Water consumed over 24 hours0.20.20.3-0.60.4-0.4-0.4-0.50.50.5-0.3-0.3-0.0-0.5
Number of responses in last shaping day1.01.02.61.0-1.11.10.90.8-0.9-0.90.61.3-0.21.6