Hub : Genes

Ide

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Ide 0.11 0.06 5.2e-09 0.12 0.12 0.12 0.13 4.0e-10 5.8e-10 8.3e-10 1.8e-10
2 Brain gene expression Ide 0.04 0.03 2.1e-03 0.02 0.03 0.03 0.03 3.6e-03 8.9e-04 1.1e-03 1.8e-03
3 Adipose mRNA stability Ide 0.12 0.05 2.8e-16 0.11 0.15 0.14 0.14 2.4e-12 4.9e-16 5.7e-15 3.3e-15
4 Liver gene expression Ide 0.11 0.05 1.6e-14 0.1 0.13 0.1 0.12 4.4e-11 5.8e-14 1.3e-11 2.3e-13
5 Adipose gene expression Ide 0.04 0.03 5.4e-05 0.03 0.04 0.03 0.03 3.2e-04 2.7e-05 3.7e-04 2.2e-04
6 Adipose alternative TSS XM_039102127.2 0.02 0.02 8.7e-03 0.01 0 -0 0 9.4e-03 1.4e-01 6.8e-01 1.4e-01
7 Brain mRNA stability Ide 0.04 0.03 3.3e-03 0.03 0.02 0.01 0.02 2.0e-03 7.6e-03 1.9e-02 3.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density4.78.713.9-3.7-2.6-3.33.3-2.62.6-2.3
Area under the delay curve0.40.60.90.70.30.9-0.90.9-0.9-0.2
BMI with tail0.10.40.7-0.60.1-0.80.7-0.70.8-0.3
BMI without tail0.00.00.0-0.2-0.0-0.10.10.00.1-0.1
Body weight0.62.67.7-2.8-2.3-1.41.3-0.80.9-0.1
Weight adjusted by age0.00.10.20.50.40.3-0.30.3-0.30.2
Bone surface4.07.910.2-3.1-2.0-3.23.2-2.82.8-2.3
Bone volume3.67.212.7-3.6-2.6-2.92.9-2.32.4-1.7
Breakpoint value in progressive ratio session0.40.81.0-0.3-0.80.8-1.01.0-1.01.0
Number of licking bursts0.82.33.92.01.31.8-1.61.4-1.51.0
Context. condit. distance diff. score1.11.44.7-1.8-2.20.1-0.30.6-0.51.0
Locomotion velocity, session 11.61.86.42.02.5-0.00.1-0.80.8-0.8
Locomotion distance, session 10.10.20.70.60.80.1-0.1-0.10.1-0.1
Locomotion velocity, session 20.30.41.01.01.00.3-0.2-0.20.5-0.4
Locomotion distance, session 20.30.50.80.50.20.9-0.90.7-0.70.8
Locomotion velocity, session 30.20.20.5-0.5-0.70.1-0.10.2-0.10.6
Locomotion distance, session 31.01.12.9-1.1-1.70.6-0.50.8-0.81.4
Stereotopy head waving bouts, day 30.60.71.20.30.8-0.90.8-1.11.0-0.9
Stereotopy head waving duration, day 30.40.50.60.40.7-0.60.6-0.80.8-0.8
Locomotion velocity, session 71.61.72.8-0.6-1.71.2-1.21.4-1.41.4
Locomotion distance, session 71.01.23.0-0.9-1.70.9-0.91.1-1.01.1
Stereotopy head waving bouts, day 70.40.50.90.20.7-0.70.7-0.80.9-0.5
Stereotopy head waving duration, day 71.41.72.7-0.20.6-1.51.6-1.61.6-1.3
Locomotion velocity, session 80.10.10.4-0.7-0.7-0.20.2-0.10.1-0.2
Locomotion distance, session 81.01.52.2-0.7-1.31.1-1.21.3-1.31.5
Degree of sensitization distance0.60.71.30.70.11.0-1.10.9-0.90.5
Degree of sensitization stereotypy0.80.91.4-0.40.3-1.11.2-1.11.2-0.8
Conditioned locomotion0.10.20.5-0.7-0.7-0.10.10.2-0.10.1
Cocaine response after cond. corrected0.10.10.2-0.00.2-0.30.4-0.40.5-0.3
Cocaine response after cond. not corrected0.10.10.2-0.3-0.40.1-0.10.3-0.20.3
Cocaine response before conditioning0.50.61.00.0-0.40.8-0.81.0-1.00.9
Saline control response1.31.82.80.3-0.21.4-1.61.7-1.61.7
Bone: connectivity density3.55.67.3-2.4-1.5-2.72.7-2.42.4-2.1
Bone: cortical apparent density0.50.82.71.61.60.6-0.60.2-0.3-0.1
Bone: cortical area1.93.18.7-3.0-2.8-1.41.4-0.70.7-0.6
Bone: cortical porosity0.20.20.40.3-0.10.5-0.60.4-0.30.7
Bone: cortical porosity0.10.10.2-0.1-0.40.2-0.30.2-0.10.4
Bone: cortical thickness0.30.41.4-1.1-1.2-0.00.10.4-0.30.3
Bone: cortical thickness0.50.61.10.60.30.8-0.70.9-0.91.1
Bone: cortical tissue density0.60.92.91.71.60.6-0.60.2-0.3-0.1
Condit. Reinf. active minus inactive responses0.80.91.40.90.31.2-1.01.0-1.01.1
Condit. Reinf. active-inactive response ratio0.30.31.21.11.00.2-0.1-0.20.2-0.1
Condit. Reinf. active responses0.81.01.6-0.1-0.71.0-1.01.1-1.21.3
Condit. Reinf. inactive responses0.50.71.7-1.1-1.30.3-0.30.7-0.80.5
Incentive salience index mean1.92.43.61.00.11.8-1.71.7-1.81.9
Condit. Reinf. lever presses1.92.93.91.40.71.9-2.01.8-1.91.8
Condit. Reinf. active minus inactive responses0.61.02.2-0.6-1.50.8-0.71.1-1.20.5
Condit. Reinf. active-inactive response ratio0.30.41.00.1-0.60.7-0.60.8-1.00.4
Condit. Reinf. active responses0.60.93.1-1.6-1.8-0.40.40.1-0.2-0.1
Condit. Reinf. inactive responses0.81.22.8-1.7-1.0-1.21.1-0.70.9-0.7
Condit. Reinf. lever presses0.10.10.2-0.3-0.0-0.30.4-0.20.1-0.5
Condit. Reinf. lever reinforcers received0.40.51.9-1.2-1.4-0.10.10.3-0.4-0.0
Conditioned reinforcement - actives0.52.13.1-1.4-1.0-1.71.8-1.51.3-1.4
Conditioned reinforcement - inactives0.41.11.4-1.2-1.0-1.11.1-1.11.0-0.8
Conditioned locomotion1.92.84.3-1.3-0.5-2.12.0-2.01.9-1.5
Patch foraging indifference point 0 sec0.30.81.20.00.4-0.91.0-1.01.0-1.1
Patch foraging indifference point AUC0.20.50.90.90.60.7-0.80.6-0.80.5
Delay disc. indifference point, 0s delay1.92.24.00.2-0.91.7-1.62.0-2.00.8
Delay disc. indifference point, 16s delay0.10.20.7-0.3-0.0-0.40.4-0.40.3-0.8
Delay disc. indifference point, 2s delay0.20.20.50.70.60.4-0.30.3-0.4-0.2
Delay disc. indifference point, 24s delay0.71.21.91.00.31.3-1.31.2-1.40.7
Delay disc. indifference point, 4s delay0.80.81.60.3-0.21.1-1.11.3-1.30.4
Delay disc. indifference point, 8s delay0.81.43.11.81.51.3-1.20.9-0.9-0.3
Indifference point function ln k0.30.81.8-1.3-1.2-0.90.9-0.70.7-0.3
Indifference point function log k0.30.81.8-1.3-1.2-0.90.9-0.70.7-0.3
Patch foraging total patch changes 0 sec0.31.01.6-0.10.4-1.11.1-1.11.2-1.2
Patch foraging total patch changes 12 sec0.50.72.41.41.50.2-0.20.0-0.1-0.8
Patch foraging total patch changes 18 sec0.10.20.70.60.80.1-0.1-0.0-0.2-0.3
Patch foraging total patch changes 24 sec0.00.10.10.2-0.10.3-0.30.3-0.20.3
Patch foraging total patch changes 6 sec0.40.61.50.91.2-0.50.6-0.70.5-0.8
Patch foraging time to switch 0 sec0.20.91.81.31.30.9-0.80.7-0.80.2
Patch foraging water rate 0 sec0.10.30.7-0.8-0.9-0.40.3-0.40.5-0.2
Patch foraging water rate 12 sec0.20.61.1-1.0-0.8-0.80.8-0.70.8-0.5
Patch foraging water rate 18 sec0.20.61.6-1.3-1.3-0.30.2-0.10.40.6
Patch foraging water rate 24 sec0.60.82.9-1.5-1.7-0.10.10.3-0.30.3
Patch foraging water rate 6 sec0.40.61.0-0.30.0-0.90.9-1.00.8-0.9
Seeking ratio, delayed vs. immediate footshock0.30.41.9-0.1-0.30.5-0.60.5-0.41.4
Distance traveled before self-admin0.40.81.30.70.11.2-1.10.9-0.81.0
Distance traveled after self-admin0.10.20.50.20.3-0.30.2-0.60.7-0.3
Extensor digitorum longus weight0.83.25.2-1.2-2.31.4-1.51.9-1.72.1
Bone: elastic displacement1.21.66.02.12.50.3-0.3-0.40.4-0.0
Bone: elastic work0.71.03.41.61.90.0-0.1-0.50.6-0.1
Bone: endosteal estimation2.97.213.2-3.6-3.1-2.82.8-2.32.1-1.4
Bone: endosteal perimeter3.27.913.5-3.7-3.0-3.03.0-2.42.1-2.2
Epididymis fat weight0.21.23.2-1.8-1.4-1.10.9-0.70.6-0.4
Delta time in closed arm before/after self-admin0.10.10.30.50.30.2-0.2-0.0-0.10.3
Delta time in open arm before/after self-admin0.30.40.60.60.20.8-0.70.7-0.70.2
Diff in mean of infusions in LGA sessions0.10.20.8-0.5-0.9-0.0-0.00.0-0.2-0.3
Delay discount exponential model param0.40.60.9-0.7-0.3-0.90.9-0.90.90.2
Extinction: sum of active levers before priming0.20.41.2-0.6-1.10.4-0.50.5-0.50.4
Active lever presses in extinction session 61.71.72.4-0.3-1.51.3-1.31.5-1.51.3
Bone: final force1.01.73.7-1.9-1.7-1.21.3-0.90.8-0.6
Bone: final moment1.42.23.5-1.9-1.5-1.61.6-1.31.3-1.0
Food consumed during 24 hour testing period0.00.00.1-0.1-0.1-0.20.4-0.20.2-0.2
Glucose0.10.20.5-0.4-0.4-0.30.3-0.30.1-0.7
Heart weight3.14.97.7-0.50.9-2.52.4-2.82.8-2.5
Delay discount hyperbolic model param0.40.50.7-0.8-0.5-0.90.8-0.80.80.2
Intermittent access intake day 1-15 change0.94.97.5-1.9-1.2-2.62.7-2.32.1-2.3
Intermittent access intake escalation0.73.96.1-1.9-1.4-2.32.5-1.91.7-2.0
Intermittent access intake escalation 20.91.52.4-1.0-1.0-1.31.5-1.20.9-1.5
Intermitt. access day 1 inactive lever presses0.00.41.01.00.90.4-0.40.1-0.3-0.5
Intermitt. access day 15 inactive lever presses0.63.24.7-1.4-0.6-2.22.1-2.11.8-1.9
Intermitt. access escalation Index0.10.51.00.70.50.7-0.60.7-1.0-0.1
Intermittent access day 1 total infusions0.30.91.6-1.3-1.0-0.90.8-0.70.8-0.7
Intermittent access day 15 total infusions2.66.38.3-2.9-2.1-2.82.9-2.32.1-2.4
Intermittent access terminal intake (last 3 days)2.84.96.6-2.3-1.5-2.52.6-2.22.0-2.2
Intermittent access total infusions2.32.74.1-2.0-1.5-1.81.8-1.51.4-1.5
Intermittent access day 1 locomotion0.50.91.7-1.3-0.9-1.11.0-0.80.9-0.5
Intermittent access day 15 total locomotion1.14.16.1-2.0-0.9-2.52.4-2.22.2-1.5
Intermittent access total locomotion1.41.72.7-1.6-1.1-1.61.4-1.31.3-0.6
Intermittent access standard deviation0.73.75.0-1.8-1.6-2.02.2-1.91.6-2.2
Left kidney weight0.32.24.9-2.2-1.7-1.51.5-1.01.1-0.9
Right kidney weight0.11.02.6-1.6-1.2-1.01.0-0.60.5-0.7
Cocaine induced anxiety0.10.40.8-0.1-0.60.7-0.60.9-0.80.4
Post-drug Anxiety0.40.40.7-0.6-0.1-0.80.8-0.60.7-0.8
Baseline Anxiety1.11.92.9-0.90.1-1.71.6-1.71.7-1.1
Tail length0.21.35.0-1.6-2.20.2-0.20.7-0.80.5
Length with tail0.73.210.0-3.1-3.2-1.21.1-0.40.3-0.3
Length without tail0.84.011.8-3.4-3.2-1.61.4-0.80.8-0.3
Times rat made contact with spout1.11.22.10.3-0.11.3-1.21.4-1.41.1
Lifetime Intake2.12.63.9-2.0-1.4-1.81.8-1.51.4-1.1
Liver weight, left0.61.02.2-1.5-1.2-1.11.0-0.70.5-0.9
Liver weight, right1.12.03.1-1.8-1.5-1.41.4-1.11.1-1.4
Locomotor activity0.20.30.90.90.90.4-0.30.00.1-0.4
Locomotor testing distance0.20.51.51.21.20.2-0.1-0.20.3-0.4
Locomotor testing rearing0.10.30.5-0.1-0.60.6-0.60.6-0.60.7
Locomotion in novel chamber0.30.41.3-0.9-1.1-0.30.4-0.10.1-0.1
Locomotion in novel chamber post-restriction0.31.03.4-1.8-1.8-0.20.10.3-0.30.6
Fecal boli incidents, locomotor time 10.30.81.5-0.1-0.70.9-1.01.1-0.91.2
Change in fecal boli incidents, locomotor task0.00.00.20.30.50.1-0.0-0.1-0.00.1
Time >=10cm from walls, locomotor time 11.51.96.2-2.2-2.50.0-0.10.6-0.41.2
Bouts of movement, locomotor time 10.10.10.2-0.5-0.4-0.20.30.1-0.2-0.2
Total resting periods, locomotor time 10.10.10.3-0.6-0.5-0.20.20.2-0.2-0.3
Rest time, locomotor task time 10.10.20.50.70.60.2-0.20.2-0.10.3
Distance moved, locomotor task time 10.20.61.3-0.1-0.60.7-0.80.8-0.81.1
Vertical activity count, locomotor time 10.00.30.5-0.7-0.4-0.60.7-0.50.3-0.7
Time >=10cm from walls, locomotor time 20.61.62.9-0.2-1.11.3-1.21.5-1.31.7
Bouts of movement, locomotor time 20.62.13.31.81.51.6-1.51.3-1.30.9
Total resting periods, locomotor time 20.62.23.31.81.31.7-1.61.5-1.41.0
Rest time, locomotor task time 20.30.51.00.3-0.20.8-0.81.0-1.00.6
Distance moved, locomotor task time 20.30.41.1-0.4-0.80.5-0.50.5-0.51.1
Vertical activity count, locomotor time 20.00.10.20.40.40.10.0-0.20.2-0.3
Light reinforcement 10.10.20.6-0.10.3-0.60.6-0.60.80.1
Light reinforcement 20.81.96.32.32.50.7-0.70.10.10.6
Bone: marrow area3.17.613.8-3.7-3.2-2.92.9-2.42.2-1.5
Bone: maximum diameter4.99.821.2-4.6-4.0-3.13.1-2.22.0-1.8
Bone: maximum force2.14.17.0-2.6-2.1-2.22.2-1.71.6-1.6
Bone: maximum moment2.75.16.5-2.5-1.8-2.52.5-2.22.1-2.0
Mean time between licks in bursts0.20.92.31.21.5-0.50.5-0.90.9-0.8
Mean num. licks in bursts0.30.92.6-1.6-1.4-0.80.7-0.50.5-0.2
Cd content in liver1.11.32.81.01.7-0.80.8-1.11.3-1.0
Co content in liver1.51.72.70.81.7-1.01.1-1.41.5-1.4
Cu content in liver1.61.95.61.62.4-0.70.8-1.20.9-1.5
Fe content in liver0.40.51.81.11.30.3-0.30.1-0.30.1
K content in liver3.33.24.51.20.22.1-2.12.0-2.12.1
Mg content in liver0.80.91.31.10.81.1-1.10.9-0.80.9
Mn content in liver0.60.72.51.31.60.5-0.50.3-0.10.2
Na content in liver2.63.04.11.50.81.9-2.01.8-1.72.0
Rb content in liver0.20.20.5-0.6-0.7-0.30.3-0.2-0.1-0.4
Se content in liver9.110.830.65.55.52.4-2.31.1-0.91.1
Sr content in liver1.51.31.90.61.3-1.01.0-1.41.3-1.1
Zn content in liver5.36.210.33.22.32.8-2.72.1-2.12.0
Bone: minimum diameter4.89.120.1-4.5-4.0-2.92.9-2.11.9-1.7
Time in familiar zone, hab. session 10.70.71.7-0.20.2-0.91.0-1.00.9-1.3
Time in novel zone, hab. session 10.91.02.00.80.31.1-1.21.0-0.71.4
Total zone transitions, hab. session 10.00.00.0-0.1-0.1-0.20.1-0.20.2-0.2
Total locomotion distance, hab. session 10.71.11.51.10.71.2-1.21.0-1.00.8
Locomotion velocity, hab. session 11.31.92.61.30.81.6-1.61.4-1.51.1
Time in familiar zone, hab. session 20.40.40.90.60.9-0.40.4-0.70.6-0.8
Time in novel zone, hab. session 20.00.00.1-0.2-0.2-0.10.1-0.00.10.0
Total zone transitions, hab. session 20.20.30.60.50.8-0.30.3-0.50.5-0.7
Total locomotion distance, hab. session 20.20.30.70.80.80.4-0.40.2-0.3-0.2
Locomotion velocity, hab. session 20.40.50.80.90.70.8-0.80.6-0.70.2
Novel to familiar place preference ratio0.30.41.2-0.6-1.10.4-0.30.5-0.60.7
Novelty place preference0.30.31.2-0.6-1.10.2-0.20.4-0.40.6
Time in novel zone, NPP test0.30.31.0-0.5-1.00.3-0.30.4-0.50.7
Total zone transitions, NPP test0.50.81.20.70.41.0-1.10.9-0.90.9
Total locomotion distance, NPP test1.42.02.71.61.11.7-1.61.4-1.41.1
Locomotion velocity, NPP test1.72.43.41.50.91.8-1.81.6-1.71.3
Intraocular pressure0.50.81.8-0.6-0.0-1.01.0-0.81.1-1.3
Delta distance traveled before/after self-admin1.61.82.3-1.3-0.8-1.51.4-1.31.4-1.5
Delta ambulatory time before/after self-admin1.22.02.7-1.5-0.9-1.61.5-1.41.5-1.2
Parametrial fat weight0.51.32.20.50.01.3-1.31.3-1.31.5
Pavlov. Cond. lever latency3.34.16.3-0.60.6-2.32.3-2.42.4-2.5
Pavlov. Cond. magazine entry latency0.50.61.00.80.31.0-0.90.8-0.80.8
Pavlov. Cond. change in total contacts0.40.50.91.00.50.8-0.70.6-0.60.5
Pavlov. Cond. index score2.02.63.70.6-0.41.9-1.81.9-1.91.8
Pavlov. Cond. latency score2.93.65.30.6-0.62.2-2.12.3-2.32.2
Pavlov. Cond. lever contacts2.63.14.30.8-0.22.1-2.02.1-2.12.0
Pavlov. Cond. magazine entry number0.10.10.2-0.5-0.2-0.40.3-0.30.3-0.2
Pavlov. Cond. intertrial magazine entries0.20.30.5-0.7-0.70.1-0.20.5-0.50.6
Pavlov. Cond. lever-magazine prob. diff.2.22.73.90.9-0.12.0-1.91.9-1.91.8
Pavlov. Cond. response bias0.40.50.90.90.50.9-0.70.5-0.50.6
Pavlov. Cond. lever latency0.40.51.2-0.0-0.50.8-0.80.8-0.61.1
Pavlov. Cond. magazine entry latency0.40.61.01.00.60.9-0.80.7-0.80.5
Pavlov. Cond. change in total contacts0.20.50.90.3-0.00.8-0.70.8-0.90.7
Pavlov. Cond. index score0.00.00.20.1-0.00.2-0.10.2-0.40.1
Pavlov. Cond. latency score0.00.00.1-0.1-0.10.10.00.2-0.4-0.0
Pavlov. Cond. lever contacts0.30.51.1-0.10.4-0.80.8-0.80.6-1.0
Pavlov. Cond. magazine entry number0.91.11.5-1.1-0.7-1.21.1-1.01.1-1.0
Pavlov. Cond. intertrial magazine entries0.40.82.3-1.1-1.50.4-0.40.8-0.60.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.30.00.4-0.30.4-0.60.3
Pavlov. Cond. response bias0.10.10.40.60.60.1-0.1-0.0-0.1-0.2
Time in closed arm before self-admin0.50.81.40.80.21.2-1.11.0-1.00.6
Time in closed arm after self-admin2.42.84.11.60.52.0-2.01.7-1.71.6
Time in open arm before self-admin0.50.61.30.10.7-0.90.8-1.11.1-0.5
Time in open arm after self-admin0.70.81.2-0.40.3-1.01.1-1.01.1-0.9
Bone: periosteal estimation3.68.517.6-4.2-3.6-3.02.9-2.22.0-1.5
Bone: periosteal perimeter2.54.911.9-3.5-3.2-2.02.0-1.31.0-1.2
Bone: post-yield work2.13.66.6-2.6-2.4-1.81.9-1.31.4-1.4
Progressive ratio test 1 active lever presses1.83.24.8-1.9-0.9-2.22.1-1.91.9-1.3
Progressive ratio test 1 breakpoint1.72.94.3-1.8-0.9-2.11.9-1.81.9-1.2
Progressive ratio test 1 inactive lever presses0.71.72.4-1.3-0.8-1.51.4-1.51.4-1.1
Progressive ratio test 2 active lever presses4.26.08.4-2.8-1.9-2.92.8-2.52.3-1.7
Progressive ratio test 2 breakpoint5.16.59.1-2.9-2.0-3.02.9-2.62.4-1.9
Progressive ratio test 2 inactive lever presses0.72.43.6-1.3-0.7-1.91.8-1.81.5-1.4
Incentive Sensitization - Responses1.43.95.0-2.2-1.7-2.22.2-1.91.7-1.8
Incentive Sensitization - Breakpoint1.94.45.6-2.3-1.8-2.42.3-2.01.8-1.9
Sum of active levers in priming session hrs 5-60.60.61.81.41.30.4-0.3-0.0-0.2-0.7
Progressive ratio0.30.92.3-0.2-0.60.8-0.91.1-1.01.5
Food seeking constrained by brief footshock1.11.44.0-2.0-2.0-0.90.9-0.50.5-0.4
Seeking ratio, punishment vs. effort0.20.41.0-0.3-0.3-0.60.6-0.70.7-1.0
Retroperitoneal fat weight0.00.10.2-0.5-0.1-0.30.0-0.20.30.5
Reaction time number correct0.10.41.5-1.0-1.2-0.30.30.1-0.1-0.2
Reaction time mean minus median0.42.33.6-0.7-0.0-1.71.9-1.81.5-1.9
Reaction time mean minus median AUC0.31.83.3-0.10.6-1.41.6-1.61.4-1.8
Reaction time num false alarms0.61.02.2-0.9-1.50.6-0.71.1-1.11.0
Reaction time num false alarms AUC0.40.81.7-0.7-1.30.7-0.71.0-1.00.9
Reaction time trials correct on left0.10.41.5-1.0-1.2-0.30.30.1-0.1-0.2
Reaction time trials on left0.10.41.5-1.0-1.2-0.30.30.1-0.1-0.2
Reaction time mean0.30.61.91.21.40.1-0.1-0.50.7-0.2
Reaction time mean AUC0.30.82.81.41.70.1-0.1-0.50.7-0.3
Median of all reaction times0.60.92.71.71.60.6-0.6-0.10.40.3
Reaction time omissions0.00.00.2-0.0-0.0-0.10.1-0.20.4-0.3
Reaction time false alarm rate0.40.50.8-0.3-0.70.6-0.70.8-0.70.9
Reaction time premature initiation rate0.40.62.3-1.5-1.2-0.40.40.00.20.4
Reaction time premature initiations0.51.55.2-2.3-2.1-0.80.8-0.10.20.0
Std. dev. reaction times0.51.82.80.10.7-1.31.5-1.71.6-1.7
Reaction time trials completed0.10.41.5-1.0-1.2-0.30.30.1-0.1-0.2
Reaction time trials AUC0.10.31.2-0.7-1.10.1-0.00.4-0.40.0
Run reversals in cocaine runway, females0.20.30.90.60.9-0.10.1-0.40.6-0.4
Run reversals in cocaine runway, males0.00.10.20.10.3-0.00.00.1-0.1-0.5
Latency to leave start box in cocaine runway0.20.30.9-0.8-0.9-0.20.1-0.00.00.5
Latency to leave start box in cocaine runway, F0.20.20.6-0.3-0.80.3-0.30.4-0.40.6
Latency to leave start box in cocaine runway, M0.30.30.8-0.9-0.5-0.50.6-0.40.30.1
Std. dev. time between licks in bursts0.61.13.71.71.9-0.00.0-0.50.2-0.9
Total sessions with >9 infusions0.40.51.0-0.30.3-1.00.8-1.00.9-0.5
Short access day 1 total inactive lever presses0.51.01.5-0.6-0.0-1.21.1-1.21.1-1.0
Short access day 10 total inactive lever presses0.21.21.80.90.31.4-1.31.3-1.30.7
Short access day 1 total infusions0.20.40.7-0.00.4-0.80.7-0.90.7-0.4
Short access day 10 total infusions0.30.61.00.00.6-0.80.7-1.01.0-0.7
Short access total infusions0.81.11.7-1.0-0.4-1.31.1-1.21.2-0.6
Short access day 1 locomotion0.10.10.60.50.7-0.1-0.0-0.30.30.4
Short access day 10 total locomotion0.10.40.70.80.70.6-0.70.4-0.40.8
Short access total locomotion0.30.41.70.91.3-0.1-0.1-0.40.50.4
One hour access (0.3 mA shock)7.28.511.8-3.4-2.6-3.33.3-2.72.5-2.5
Compulsive drug intake0.10.20.6-0.8-0.7-0.10.10.00.10.6
One hour access (shock baseline)1.53.95.0-2.2-1.6-2.22.2-1.81.7-1.9
Social response proportion0.20.20.40.20.2-0.50.5-0.60.5-0.6
Social responses1.62.13.2-0.8-0.2-1.81.7-1.81.6-1.4
Social time0.20.30.70.90.70.5-0.60.3-0.10.5
Soleus weight1.03.13.9-2.0-1.4-2.01.9-1.81.7-1.3
Bone: stiffness1.42.68.5-2.7-2.9-1.01.0-0.30.4-0.2
Tibialis anterior weight1.65.47.2-0.9-2.52.1-2.22.7-2.62.6
Time to tail flick, vehicle, before self-admin0.40.52.21.01.5-0.0-0.1-0.30.3-0.4
Time to tail flick, vehicle, after self-admin2.04.06.0-0.2-1.62.2-2.22.5-2.42.1
Time to tail flick, test, before self-admin0.50.61.7-1.3-1.3-0.20.1-0.10.10.7
Time to tail flick, test, after self-admin1.81.93.01.71.01.6-1.61.2-1.21.0
Delta time to tail flick, vehicle, before/after SA4.95.29.0-1.4-3.01.9-1.82.5-2.42.6
Delta time to tail flick, test, before/after SA0.70.82.01.41.00.9-0.90.7-0.70.3
Tibia length0.20.50.7-0.8-0.4-0.80.9-0.70.5-0.6
Ambulatory time before self-admin0.41.11.71.20.61.3-1.30.9-0.90.9
Ambulatory time after self-admin0.00.10.3-0.1-0.1-0.10.1-0.40.5-0.1
Bone: tissue strength0.90.92.00.10.4-0.90.8-1.21.1-1.4
Total heroin consumption0.30.31.1-1.0-1.0-0.1-0.10.2-0.10.5
Bone: trabecular number3.97.39.9-3.0-1.8-3.13.1-2.62.6-2.4
Bone: trabecular spacing1.72.53.31.60.81.8-1.71.7-1.61.7
Bone: trabecular thickness3.04.17.1-2.7-1.9-2.22.1-1.81.8-1.5
Bone: trabecular tissue density0.30.51.5-1.2-1.1-0.60.5-0.20.2-0.4
Water consumed over 24 hours1.42.64.30.4-0.71.9-1.82.0-2.11.6
Number of responses in last shaping day3.24.16.4-0.60.8-2.52.5-2.52.3-2.0