Ide

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Ide	0.1	0.06	1.3e-04	0.09	0.08	0.07	0.09	1.5e-04	1.7e-04	4.1e-04	1.1e-04
2	Brain	gene expression	Ide	0.03	0.02	8.2e-03	0.01	0.03	0.02	0.02	1.2e-02	1.7e-03	1.1e-02	8.3e-03
3	Liver	gene expression	Ide	0.12	0.05	2.9e-15	0.1	0.14	0.13	0.12	8.0e-11	8.6e-15	7.1e-14	1.6e-13
4	Adipose	mRNA stability	Ide	0.18	0.07	0.0e+00	0.22	0.23	0.22	0.22	1.7e-24	3.1e-25	3.0e-24	2.5e-24
5	Adipose	gene expression	Ide	0.04	0.03	6.7e-05	0.02	0.04	0.03	0.03	9.2e-04	3.0e-05	1.3e-04	1.2e-04
6	Brain	mRNA stability	Ide	0.04	0.03	8.5e-04	0.02	0.03	0.01	0.03	2.5e-03	8.4e-04	1.6e-02	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	4.9	8.2	13.2	-3.6	-2.4	3.2	-3.0	-2.5	2.2
Area under the delay curve	0.6	0.6	0.9	0.7	0.3	-0.9	1.0	0.9	-0.7
BMI with tail	0.0	0.1	0.2	-0.5	-0.1	0.4	-0.4	-0.4	0.3
BMI without tail	0.1	0.2	0.3	-0.3	-0.0	0.5	-0.5	-0.5	0.5
Body weight	0.5	2.3	6.5	-2.5	-2.3	1.1	-0.8	-0.4	0.1
Weight adjusted by age	0.1	0.2	0.5	0.7	0.6	-0.2	0.2	0.1	0.1
Bone surface	4.0	7.1	9.6	-2.9	-1.7	3.1	-3.0	-2.6	2.4
Bone volume	3.6	6.2	10.7	-3.3	-2.3	2.7	-2.5	-2.1	1.8
Breakpoint value in progressive ratio session	0.6	0.7	1.6	-0.9	-1.3	-0.6	0.6	0.8	-0.8
Number of licking bursts	2.0	2.4	3.9	2.0	1.4	-1.6	1.6	1.4	-1.2
Context. condit. distance diff. score	1.2	1.5	4.7	-1.6	-2.2	-0.3	0.3	0.7	-1.0
Locomotion velocity, session 1	2.1	2.2	7.0	2.0	2.7	0.2	-0.4	-0.9	1.1
Locomotion distance, session 1	0.2	0.2	0.7	0.7	0.8	-0.1	-0.0	-0.2	0.2
Locomotion velocity, session 2	0.4	0.4	1.4	1.0	1.2	-0.1	-0.1	-0.3	0.3
Locomotion distance, session 2	0.3	0.4	0.6	0.6	0.2	-0.8	0.8	0.7	-0.8
Locomotion velocity, session 3	0.1	0.1	0.4	-0.5	-0.6	0.0	-0.0	0.1	-0.2
Locomotion distance, session 3	0.9	1.0	2.4	-1.0	-1.5	-0.4	0.6	0.8	-1.1
Stereotopy head waving bouts, day 3	0.8	0.9	1.4	0.3	0.9	0.9	-1.0	-1.2	1.2
Stereotopy head waving duration, day 3	0.4	0.5	0.9	0.4	0.7	0.5	-0.7	-0.8	0.9
Locomotion velocity, session 7	1.7	1.8	2.7	-0.5	-1.6	-1.3	1.3	1.5	-1.6
Locomotion distance, session 7	1.0	1.3	2.7	-0.8	-1.6	-0.9	0.9	1.2	-1.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	0.1	0.5	0.7	-0.7	-0.8	0.8
Stereotopy head waving duration, day 7	1.4	1.7	2.6	-0.3	0.5	1.6	-1.5	-1.6	1.6
Locomotion velocity, session 8	0.1	0.1	0.4	-0.6	-0.6	0.2	-0.2	-0.1	0.0
Locomotion distance, session 8	1.0	1.5	2.5	-0.5	-1.3	-1.2	1.1	1.3	-1.6
Degree of sensitization distance	0.8	0.8	1.5	0.7	-0.0	-1.2	1.1	1.1	-0.8
Degree of sensitization stereotypy	0.8	0.9	1.4	-0.5	0.1	1.2	-1.1	-1.1	1.1
Conditioned locomotion	0.2	0.2	0.7	-0.8	-0.8	0.1	0.1	0.3	-0.3
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.1	0.1	0.4	-0.4	-0.4	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.4	-0.6	-0.0	0.2	0.3	-0.3
Cocaine response before conditioning	0.6	0.7	1.1	0.0	-0.5	-0.9	1.0	1.0	-1.0
Saline control response	1.1	1.5	2.4	0.6	-0.1	-1.6	1.5	1.5	-1.3
Bone: connectivity density	3.6	5.7	7.7	-2.5	-1.5	2.8	-2.7	-2.4	2.2
Bone: cortical apparent density	0.8	1.1	3.0	1.7	1.7	-0.7	0.6	0.3	0.1
Bone: cortical area	1.8	2.7	6.8	-2.6	-2.6	1.2	-0.9	-0.5	0.2
Bone: cortical porosity	0.2	0.2	0.5	0.5	0.1	-0.7	0.5	0.5	-0.4
Bone: cortical porosity	0.0	0.0	0.1	0.0	-0.3	-0.3	0.2	0.2	-0.2
Bone: cortical thickness	0.2	0.3	0.8	-0.8	-0.9	-0.0	0.3	0.5	-0.5
Bone: cortical thickness	0.6	0.7	1.1	0.7	0.3	-0.8	1.0	1.0	-0.8
Bone: cortical tissue density	0.9	1.1	3.1	1.8	1.7	-0.7	0.5	0.2	0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	0.9	0.4	-1.0	1.0	0.9	-1.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	1.0	1.1	-0.0	-0.0	-0.2	0.2
Condit. Reinf. active responses	0.7	0.9	1.5	-0.0	-0.7	-0.9	1.1	1.2	-1.2
Condit. Reinf. inactive responses	0.6	0.8	1.6	-1.0	-1.3	-0.4	0.6	0.9	-0.9
Incentive salience index mean	1.7	2.1	3.1	1.0	0.1	-1.6	1.8	1.7	-1.7
Condit. Reinf. lever presses	1.9	2.5	3.6	1.3	0.5	-1.9	1.9	1.8	-1.7
Condit. Reinf. active minus inactive responses	1.1	1.4	2.2	-0.5	-1.5	-0.9	1.1	1.3	-1.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.9	0.1	-0.5	-0.7	0.9	1.0	-1.0
Condit. Reinf. active responses	0.8	1.1	3.6	-1.6	-1.9	0.2	0.0	0.4	-0.5
Condit. Reinf. inactive responses	1.0	1.2	2.9	-1.7	-1.2	1.0	-0.9	-0.7	0.6
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.3	-0.2	0.3
Condit. Reinf. lever reinforcers received	0.5	0.7	2.3	-1.2	-1.5	-0.1	0.2	0.5	-0.6
Conditioned reinforcement - actives	1.6	1.6	3.4	-1.8	-1.5	1.4	-1.1	-0.8	0.7
Conditioned reinforcement - inactives	1.5	1.7	3.0	-1.7	-1.4	1.3	-1.3	-1.0	0.8
Conditioned locomotion	2.2	2.7	3.7	-1.4	-0.5	1.9	-1.9	-1.8	1.8
Patch foraging indifference point 0 sec	0.4	0.7	1.1	-0.2	0.4	1.0	-1.0	-1.0	0.9
Patch foraging indifference point AUC	0.5	0.6	1.0	1.0	0.6	-1.0	0.8	0.7	-0.5
Delay disc. indifference point, 0s delay	2.2	2.5	4.1	0.2	-1.0	-1.6	1.9	2.0	-1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.2	-0.0	0.2	-0.3	-0.3	0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	0.7	0.6	-0.3	0.3	0.2	0.0
Delay disc. indifference point, 24s delay	1.0	0.9	1.4	0.8	0.2	-1.2	1.2	1.1	-0.9
Delay disc. indifference point, 4s delay	1.2	1.2	2.0	0.4	-0.3	-1.3	1.4	1.4	-1.2
Delay disc. indifference point, 8s delay	1.4	1.4	3.1	1.8	1.4	-1.1	1.1	0.8	-0.5
Indifference point function ln k	0.8	1.1	2.4	-1.5	-1.3	1.1	-1.0	-0.7	0.4
Indifference point function log k	0.8	1.1	2.4	-1.5	-1.3	1.1	-1.0	-0.7	0.4
Patch foraging total patch changes 0 sec	0.5	0.9	1.4	-0.3	0.3	1.2	-1.1	-1.1	1.1
Patch foraging total patch changes 12 sec	0.6	0.7	2.4	1.3	1.5	-0.2	0.2	-0.0	0.3
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	0.5	0.7	-0.1	0.1	0.0	0.1
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.2	-0.1	-0.3	0.2	0.2	-0.3
Patch foraging total patch changes 6 sec	0.5	0.7	1.6	0.8	1.3	0.6	-0.6	-0.8	0.9
Patch foraging time to switch 0 sec	0.5	0.8	1.8	1.4	1.3	-0.7	0.8	0.6	-0.4
Patch foraging water rate 0 sec	0.2	0.3	0.7	-0.8	-0.8	0.3	-0.4	-0.3	0.1
Patch foraging water rate 12 sec	0.5	0.7	1.3	-1.1	-0.8	0.9	-0.9	-0.7	0.5
Patch foraging water rate 18 sec	0.5	0.7	2.0	-1.4	-1.4	0.4	-0.4	-0.2	-0.1
Patch foraging water rate 24 sec	0.7	1.0	3.1	-1.6	-1.7	0.2	-0.0	0.3	-0.5
Patch foraging water rate 6 sec	0.4	0.6	0.8	-0.5	0.0	0.9	-0.9	-0.9	0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.2	-0.5	-0.5	0.4	0.5	-0.6
Distance traveled before self-admin	0.7	0.7	1.1	0.5	-0.1	-1.0	1.0	0.9	-1.0
Distance traveled after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3
Extensor digitorum longus weight	0.9	3.4	5.1	-1.0	-2.3	-1.7	1.7	2.0	-2.2
Bone: elastic displacement	1.5	1.7	5.7	2.0	2.4	-0.2	-0.1	-0.5	0.8
Bone: elastic work	0.9	1.2	3.5	1.5	1.9	0.0	-0.3	-0.6	0.9
Bone: endosteal estimation	3.3	7.1	12.1	-3.5	-2.9	2.7	-2.7	-2.1	1.8
Bone: endosteal perimeter	3.6	7.4	12.7	-3.6	-2.9	2.8	-2.7	-2.2	1.8
Epididymis fat weight	0.3	0.6	0.9	-0.6	-1.0	-0.5	0.7	0.8	-0.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.4	-0.1	-0.5	0.5	0.5	-0.6
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.3	-0.0	-0.7	0.7	0.7	-0.6
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	-0.4	-1.0	-0.4	0.4	0.6	-0.6
Delay discount exponential model param	0.6	0.6	0.9	-0.8	-0.3	0.9	-1.0	-0.9	0.7
Extinction: sum of active levers before priming	0.3	0.3	0.9	-0.6	-0.9	-0.4	0.2	0.4	-0.5
Active lever presses in extinction session 6	1.0	1.0	2.3	-0.7	-1.5	-0.6	0.7	1.0	-1.1
Bone: final force	0.8	1.2	2.5	-1.6	-1.4	1.1	-1.0	-0.7	0.5
Bone: final moment	1.0	1.6	2.4	-1.5	-1.1	1.4	-1.4	-1.2	1.0
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.1	0.1	0.3	-0.2	-0.2	0.1
Glucose	0.1	0.2	0.4	-0.6	-0.6	0.4	-0.4	-0.2	0.2
Heart weight	1.6	2.3	3.6	-0.2	0.8	1.7	-1.8	-1.9	1.9
Delay discount hyperbolic model param	0.5	0.5	0.8	-0.8	-0.4	0.8	-0.9	-0.8	0.6
Intermittent access intake day 1-15 change	4.7	4.6	7.0	-2.0	-1.0	2.6	-2.5	-2.3	2.0
Intermittent access intake escalation	5.3	5.2	8.3	-2.0	-0.8	2.9	-2.7	-2.5	2.2
Intermittent access intake escalation 2	2.7	2.7	4.4	-1.2	-0.5	2.1	-2.0	-1.9	1.6
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.5	0.3	0.5	0.4	-0.5	-0.6	0.7
Intermitt. access day 15 inactive lever presses	3.0	3.3	5.0	-1.2	-0.2	2.0	-2.2	-2.1	2.2
Intermitt. access escalation Index	0.4	0.3	0.5	0.3	-0.2	-0.6	0.7	0.7	-0.6
Intermittent access day 1 total infusions	0.4	0.5	1.7	-1.0	-1.3	0.0	0.0	0.3	-0.3
Intermittent access day 15 total infusions	4.7	5.3	7.9	-2.8	-2.0	2.7	-2.4	-2.0	1.7
Intermittent access terminal intake (last 3 days)	2.9	3.1	4.4	-2.0	-1.4	2.1	-1.9	-1.6	1.4
Intermittent access total infusions	1.3	1.4	3.1	-1.8	-1.6	1.2	-1.0	-0.7	0.5
Intermittent access day 1 locomotion	0.2	0.2	0.8	-0.8	-0.9	0.2	-0.1	0.0	-0.1
Intermittent access day 15 total locomotion	2.3	2.4	3.5	-1.5	-0.6	1.8	-1.9	-1.7	1.6
Intermittent access total locomotion	0.1	0.1	0.3	-0.6	-0.6	0.1	-0.2	-0.1	0.0
Intermittent access standard deviation	2.4	2.6	4.0	-1.5	-1.0	2.0	-1.8	-1.6	1.4
Left kidney weight	0.3	0.9	2.4	-1.5	-1.4	0.8	-0.5	-0.2	0.0
Right kidney weight	0.1	0.3	0.8	-0.9	-0.8	0.6	-0.3	-0.2	0.0
Cocaine induced anxiety	1.3	1.6	2.4	0.7	-0.1	-1.4	1.5	1.6	-1.5
Post-drug Anxiety	0.4	0.4	0.7	0.9	0.8	-0.7	0.7	0.5	-0.2
Baseline Anxiety	0.5	0.5	1.0	0.1	0.6	0.6	-0.8	-0.9	1.0
Tail length	0.4	1.1	3.8	-1.5	-2.0	0.1	0.1	0.4	-0.6
Length with tail	0.7	2.6	8.0	-2.6	-2.8	0.8	-0.4	0.1	-0.3
Length without tail	1.0	2.2	6.6	-2.0	-2.6	-0.1	0.5	0.9	-1.1
Times rat made contact with spout	1.0	1.1	1.9	0.4	-0.2	-1.3	1.3	1.4	-1.2
Lifetime Intake	1.1	1.2	2.4	-1.6	-1.3	1.1	-1.0	-0.7	0.6
Liver weight, left	1.4	2.2	7.0	-2.3	-2.6	0.3	-0.0	0.5	-0.8
Liver weight, right	0.9	1.5	3.1	-1.0	-1.8	-0.8	0.9	1.3	-1.3
Locomotor activity	0.2	0.3	0.9	1.0	0.9	-0.3	0.2	0.0	-0.1
Locomotor testing distance	0.2	0.4	1.2	1.1	1.1	-0.1	0.0	-0.2	0.1
Locomotor testing rearing	0.2	0.3	0.7	-0.1	-0.6	-0.6	0.6	0.6	-0.8
Locomotion in novel chamber	0.6	0.7	1.4	-1.2	-1.0	0.9	-0.8	-0.6	0.4
Locomotion in novel chamber post-restriction	1.1	1.3	4.1	-1.8	-2.0	0.1	0.1	0.5	-0.7
Fecal boli incidents, locomotor time 1	0.7	0.7	1.1	0.1	-0.6	-1.0	0.9	1.0	-1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.0	0.4	0.3	-0.3	-0.4	0.3
Time >=10cm from walls, locomotor time 1	2.1	2.1	6.8	-2.2	-2.6	0.0	0.1	0.6	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.5	-0.6	0.3	-0.1	-0.0	-0.0
Total resting periods, locomotor time 1	0.2	0.2	0.6	-0.6	-0.7	0.2	-0.0	0.1	-0.2
Rest time, locomotor task time 1	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1	0.2
Distance moved, locomotor task time 1	0.4	0.5	0.8	0.1	-0.3	-0.8	0.8	0.8	-0.9
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.4	-0.0	0.6	-0.4	-0.4	0.3
Time >=10cm from walls, locomotor time 2	1.4	1.5	2.5	-0.3	-1.2	-1.1	1.3	1.5	-1.6
Bouts of movement, locomotor time 2	2.2	2.3	3.8	1.9	1.4	-1.6	1.6	1.3	-1.1
Total resting periods, locomotor time 2	2.4	2.5	3.8	1.9	1.3	-1.7	1.7	1.5	-1.3
Rest time, locomotor task time 2	0.5	0.5	0.9	0.2	-0.4	-0.7	0.9	0.9	-0.9
Distance moved, locomotor task time 2	0.2	0.3	0.4	-0.4	-0.7	-0.5	0.4	0.5	-0.6
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.2	0.5	0.2	-0.2	-0.3	0.4
Light reinforcement 1	0.1	0.3	0.4	-0.2	0.1	0.6	-0.6	-0.6	0.6
Light reinforcement 2	1.4	1.9	5.6	2.2	2.4	-0.6	0.4	0.0	0.4
Bone: marrow area	3.5	7.5	12.6	-3.5	-2.9	2.7	-2.8	-2.2	1.9
Bone: maximum diameter	5.1	9.3	19.1	-4.4	-3.7	3.0	-2.7	-2.0	1.6
Bone: maximum force	2.1	3.6	5.8	-2.4	-1.8	2.0	-1.9	-1.6	1.4
Bone: maximum moment	2.5	4.4	5.7	-2.3	-1.5	2.4	-2.3	-2.0	1.8
Mean time between licks in bursts	0.8	1.1	2.2	1.0	1.5	0.6	-0.8	-1.0	1.1
Mean num. licks in bursts	0.8	1.0	2.4	-1.6	-1.4	0.7	-0.7	-0.4	0.4
Cd content in liver	0.6	0.7	0.9	0.1	0.7	1.0	-0.8	-0.9	1.0
Co content in liver	1.6	1.9	3.4	1.0	1.8	1.0	-1.1	-1.5	1.6
Cu content in liver	1.8	2.2	6.6	1.8	2.6	0.3	-0.5	-0.9	1.3
Fe content in liver	1.6	1.9	4.9	2.1	2.2	-0.9	0.9	0.4	-0.3
K content in liver	2.3	2.3	3.3	1.1	0.3	-1.8	1.8	1.7	-1.6
Mg content in liver	1.5	1.6	2.3	1.5	1.0	-1.4	1.3	1.1	-1.0
Mn content in liver	1.2	1.3	2.3	1.5	1.3	-1.1	1.2	0.9	-0.8
Na content in liver	4.1	4.3	6.1	1.9	0.9	-2.5	2.5	2.3	-2.1
Rb content in liver	0.3	0.4	0.5	-0.2	-0.7	-0.6	0.6	0.7	-0.7
Se content in liver	9.8	12.0	31.2	5.5	5.6	-2.3	1.9	0.9	-0.3
Sr content in liver	2.3	2.1	3.3	-0.4	0.5	1.6	-1.8	-1.8	1.8
Zn content in liver	5.7	6.3	12.5	3.5	2.7	-2.7	2.3	1.8	-1.5
Bone: minimum diameter	5.0	9.3	19.8	-4.5	-4.0	2.8	-2.6	-1.8	1.3
Time in familiar zone, hab. session 1	0.7	0.6	1.0	-0.2	0.3	0.9	-0.9	-0.9	1.0
Time in novel zone, hab. session 1	0.8	0.8	1.3	0.8	0.2	-1.1	1.0	1.0	-0.9
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.0	0.1	0.2	-0.2	-0.2	0.2
Total locomotion distance, hab. session 1	0.8	1.1	1.4	1.1	0.8	-1.2	1.1	1.0	-1.0
Locomotion velocity, hab. session 1	1.3	1.9	2.5	1.4	0.8	-1.6	1.5	1.4	-1.3
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.5	0.9	0.5	-0.6	-0.8	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.1	-0.0	-0.0
Total zone transitions, hab. session 2	0.2	0.3	0.7	0.6	0.9	0.3	-0.4	-0.5	0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.7	0.9	0.8	-0.4	0.3	0.2	-0.2
Locomotion velocity, hab. session 2	0.4	0.6	0.9	0.9	0.6	-0.8	0.8	0.6	-0.7
Novel to familiar place preference ratio	0.4	0.4	0.9	-0.6	-1.0	-0.3	0.4	0.6	-0.6
Novelty place preference	0.3	0.3	1.0	-0.7	-1.0	-0.1	0.2	0.4	-0.4
Time in novel zone, NPP test	0.3	0.3	0.8	-0.5	-0.9	-0.3	0.3	0.5	-0.5
Total zone transitions, NPP test	0.6	0.8	1.2	1.0	0.5	-1.1	1.0	0.8	-0.9
Total locomotion distance, NPP test	1.5	2.1	2.8	1.7	1.1	-1.7	1.6	1.3	-1.3
Locomotion velocity, NPP test	1.8	2.5	3.5	1.6	0.9	-1.9	1.8	1.6	-1.5
Intraocular pressure	0.5	0.8	1.2	-0.8	-0.1	1.1	-1.0	-0.9	0.9
Delta distance traveled before/after self-admin	0.7	0.7	0.9	-1.0	-0.6	0.9	-0.9	-0.8	0.9
Delta ambulatory time before/after self-admin	1.0	1.1	2.0	-1.4	-1.1	1.0	-1.0	-0.8	0.8
Parametrial fat weight	0.2	0.3	0.9	-1.0	-1.0	0.3	-0.1	0.0	-0.0
Pavlov. Cond. lever latency	2.7	3.4	5.2	-0.7	0.5	2.2	-2.2	-2.2	2.3
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	1.0	0.5	-1.0	1.0	0.9	-1.0
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.9	0.6	-0.6	0.7	0.6	-0.7
Pavlov. Cond. index score	2.0	2.5	4.1	0.6	-0.3	-1.8	1.9	1.9	-2.0
Pavlov. Cond. latency score	2.8	3.6	5.8	0.6	-0.6	-2.1	2.3	2.3	-2.4
Pavlov. Cond. lever contacts	2.8	3.3	5.1	0.8	-0.4	-2.1	2.2	2.2	-2.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.7	-0.7	-0.9	-0.1	0.3	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.8	4.3	0.9	-0.1	-1.9	2.0	2.0	-2.1
Pavlov. Cond. response bias	0.6	0.7	0.9	0.9	0.5	-0.9	0.9	0.8	-0.9
Pavlov. Cond. lever latency	0.5	0.6	1.1	-0.1	-0.6	-0.9	0.8	0.9	-1.0
Pavlov. Cond. magazine entry latency	0.5	0.6	0.7	0.8	0.3	-0.8	0.9	0.8	-0.8
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	0.3	-0.1	-0.8	0.8	0.8	-0.7
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	-0.1	-0.1	0.3	0.3	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.2	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.1	0.2	0.5	-0.5	-0.6	0.7
Pavlov. Cond. magazine entry number	1.0	1.3	1.6	-1.3	-0.7	1.3	-1.3	-1.1	1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.9	-0.9	-1.4	-0.5	0.7	0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.2	-0.1	-0.4	0.6	0.6	-0.5
Pavlov. Cond. response bias	0.1	0.2	0.4	0.6	0.5	-0.4	0.4	0.3	-0.2
Time in closed arm before self-admin	0.4	0.5	0.6	0.7	0.2	-0.8	0.8	0.7	-0.7
Time in closed arm after self-admin	3.0	3.1	4.5	1.2	-0.0	-2.1	2.1	2.0	-2.0
Time in open arm before self-admin	0.4	0.5	0.8	0.0	0.5	0.7	-0.8	-0.9	0.8
Time in open arm after self-admin	0.7	0.7	1.2	-0.7	-0.1	1.1	-1.0	-0.9	0.9
Bone: periosteal estimation	3.6	7.5	14.8	-3.8	-3.3	2.6	-2.5	-1.9	1.5
Bone: periosteal perimeter	2.8	4.7	10.9	-3.3	-3.1	1.8	-1.6	-1.1	0.7
Bone: post-yield work	2.4	3.3	6.6	-2.6	-2.2	1.9	-1.6	-1.2	0.9
Progressive ratio test 1 active lever presses	0.8	0.9	1.8	-1.3	-1.1	0.9	-0.9	-0.6	0.6
Progressive ratio test 1 breakpoint	0.8	0.8	1.6	-1.3	-0.9	0.9	-0.9	-0.7	0.7
Progressive ratio test 1 inactive lever presses	1.0	1.1	2.0	-1.4	-1.3	0.9	-1.1	-0.8	0.7
Progressive ratio test 2 active lever presses	3.8	4.1	6.4	-2.5	-1.9	2.2	-2.1	-1.8	1.5
Progressive ratio test 2 breakpoint	4.2	4.8	7.7	-2.8	-2.1	2.3	-2.3	-1.8	1.6
Progressive ratio test 2 inactive lever presses	1.7	2.0	2.7	-1.5	-0.9	1.6	-1.6	-1.4	1.3
Incentive Sensitization - Responses	4.0	4.1	5.5	-2.4	-1.7	2.3	-2.2	-1.8	1.6
Incentive Sensitization - Breakpoint	4.1	4.2	5.9	-2.4	-1.7	2.3	-2.2	-1.9	1.6
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.0	0.7	1.0	0.4	-0.4	-0.6	0.7
Progressive ratio	0.5	0.6	1.1	-0.7	-1.0	-0.4	0.6	0.7	-0.9
Food seeking constrained by brief footshock	1.5	1.9	4.5	-2.1	-2.0	1.2	-1.0	-0.7	0.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.5	-0.3	-0.2	0.6	-0.7	-0.7	0.6
Retroperitoneal fat weight	0.1	0.2	0.5	-0.7	-0.7	0.1	-0.1	-0.0	-0.0
Reaction time number correct	0.3	0.5	1.4	-1.0	-1.2	0.4	-0.2	0.0	-0.2
Reaction time mean minus median	1.8	2.3	3.8	-0.8	0.2	1.9	-1.8	-1.8	1.7
Reaction time mean minus median AUC	1.4	1.9	2.9	-0.1	0.8	1.7	-1.6	-1.7	1.6
Reaction time num false alarms	0.9	1.2	2.1	-0.7	-1.4	-0.9	1.0	1.2	-1.3
Reaction time num false alarms AUC	0.7	0.9	1.5	-0.5	-1.2	-0.8	0.9	1.1	-1.2
Reaction time trials correct on left	0.3	0.5	1.4	-1.0	-1.2	0.4	-0.2	0.0	-0.2
Reaction time trials on left	0.3	0.5	1.4	-1.0	-1.2	0.4	-0.2	0.1	-0.2
Reaction time mean	0.6	0.8	2.5	1.2	1.6	0.0	-0.3	-0.6	0.6
Reaction time mean AUC	0.8	1.0	3.3	1.4	1.8	-0.0	-0.3	-0.6	0.7
Median of all reaction times	0.8	1.2	3.5	1.7	1.9	-0.6	0.2	-0.2	0.3
Reaction time omissions	0.1	0.1	0.1	-0.1	-0.0	0.4	-0.3	-0.4	0.1
Reaction time false alarm rate	0.4	0.6	0.8	-0.2	-0.7	-0.8	0.7	0.9	-0.9
Reaction time premature initiation rate	0.5	0.6	2.0	-1.4	-1.2	0.4	-0.3	-0.0	-0.1
Reaction time premature initiations	1.2	1.7	4.9	-2.2	-2.0	0.9	-0.6	-0.2	-0.1
Std. dev. reaction times	1.4	1.9	3.1	-0.0	0.9	1.6	-1.6	-1.8	1.6
Reaction time trials completed	0.3	0.5	1.4	-1.0	-1.2	0.4	-0.2	0.1	-0.2
Reaction time trials AUC	0.2	0.3	1.1	-0.7	-1.0	0.1	0.2	0.4	-0.4
Run reversals in cocaine runway, females	0.3	0.3	1.0	0.7	1.0	0.1	-0.2	-0.4	0.5
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	-0.1
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.7	-0.8	0.2	-0.3	-0.2	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.2	-0.5	-0.1	-0.0	0.0	-0.2
Latency to leave start box in cocaine runway, M	0.3	0.3	0.9	-1.0	-0.6	0.6	-0.5	-0.4	0.2
Std. dev. time between licks in bursts	1.0	1.2	3.7	1.6	1.9	-0.0	-0.1	-0.5	0.7
Total sessions with >9 infusions	0.5	0.5	0.8	-0.7	-0.4	0.7	-0.9	-0.8	0.7
Short access day 1 total inactive lever presses	1.7	1.9	2.9	-0.7	0.2	1.6	-1.7	-1.7	1.7
Short access day 10 total inactive lever presses	0.7	0.7	1.6	1.3	1.1	-0.9	0.7	0.5	-0.3
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	0.1	0.3	-0.3	-0.4	0.4
Short access day 10 total infusions	0.2	0.2	0.3	-0.2	-0.0	0.5	-0.6	-0.5	0.5
Short access total infusions	0.4	0.5	1.0	-1.0	-0.8	0.7	-0.7	-0.5	0.4
Short access day 1 locomotion	0.0	0.0	0.0	0.1	0.0	-0.2	0.1	0.1	-0.0
Short access day 10 total locomotion	0.1	0.2	0.3	0.5	0.4	-0.5	0.4	0.3	-0.3
Short access total locomotion	0.2	0.2	0.4	0.6	0.6	-0.4	0.2	0.0	0.1
One hour access (0.3 mA shock)	5.9	6.9	12.5	-3.5	-2.9	2.9	-2.5	-1.9	1.6
Compulsive drug intake	0.5	0.5	1.6	-1.1	-1.3	0.3	-0.2	0.0	-0.1
One hour access (shock baseline)	1.9	2.2	3.1	-1.8	-1.3	1.7	-1.6	-1.3	1.1
Social response proportion	0.2	0.2	0.4	0.2	0.2	0.5	-0.6	-0.6	0.6
Social responses	1.7	2.1	3.2	-0.9	-0.2	1.7	-1.8	-1.7	1.7
Social time	0.3	0.4	0.9	1.0	0.8	-0.6	0.4	0.3	-0.2
Soleus weight	0.9	2.7	3.8	-1.7	-1.1	1.7	-2.0	-1.7	1.6
Bone: stiffness	1.6	2.5	7.7	-2.5	-2.8	0.7	-0.5	-0.0	-0.2
Tibialis anterior weight	1.6	5.6	8.1	-0.7	-2.5	-2.3	2.4	2.8	-2.8
Time to tail flick, vehicle, before self-admin	0.6	0.6	2.1	1.1	1.4	-0.2	-0.0	-0.3	0.6
Time to tail flick, vehicle, after self-admin	2.5	2.7	4.0	-0.5	-1.7	-1.6	1.6	1.9	-2.0
Time to tail flick, test, before self-admin	1.4	1.3	3.8	-1.5	-2.0	-0.5	0.4	0.8	-0.9
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.8	0.3	-0.7	0.6	0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	4.2	4.1	9.1	-1.6	-3.0	-1.2	1.5	2.0	-2.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.6	0.4	-0.0	0.1	0.1	0.1
Tibia length	0.2	0.6	1.0	-0.8	-0.3	1.0	-0.9	-0.8	0.7
Ambulatory time before self-admin	1.0	1.0	1.5	1.1	0.5	-1.2	1.1	1.0	-1.0
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.0	0.0	-0.0
Bone: tissue strength	1.1	1.0	1.8	0.1	0.6	0.9	-1.2	-1.3	1.3
Total heroin consumption	0.3	0.4	1.1	-1.1	-1.0	0.3	-0.3	-0.1	0.0
Bone: trabecular number	4.7	7.4	10.4	-3.1	-1.8	3.2	-3.0	-2.6	2.4
Bone: trabecular spacing	1.9	2.5	3.3	1.7	0.9	-1.8	1.8	1.6	-1.5
Bone: trabecular thickness	3.3	4.0	6.4	-2.5	-1.6	2.2	-2.1	-1.8	1.5
Bone: trabecular tissue density	0.4	0.5	1.6	-1.2	-1.3	0.3	-0.3	-0.0	-0.0
Water consumed over 24 hours	2.5	2.9	4.3	0.8	-0.4	-2.1	2.1	2.1	-2.0
Number of responses in last shaping day	2.3	2.4	3.7	-1.6	-0.6	1.9	-1.7	-1.6	1.5