Htr1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Htr1a	0.16	0.06	0.0e+00	0.32	0.34	0.34	0.34	3.5e-36	3.3e-38	7.1e-39	2.5e-38
2	IL	gene expression	Htr1a	0.26	0.13	1.3e-06	0.18	0.16	0.19	0.18	3.3e-05	1.4e-04	2.5e-05	4.5e-05
3	Brain	gene expression	Htr1a	0.2	0.1	0.0e+00	0.24	0.24	0.25	0.24	7.4e-22	1.5e-22	5.4e-23	1.5e-22
4	OFC	gene expression	Htr1a	0.26	0.13	2.2e-06	0.19	0.2	0.19	0.23	2.9e-05	1.4e-05	2.7e-05	3.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	1.3	2.2	3.6	1.4	1.2	1.4	-1.9
Area under the delay curve	0.2	0.2	0.3	0.3	0.6	0.3	-0.4
BMI with tail	2.6	8.3	11.9	2.5	2.3	3.5	-3.1
BMI without tail	1.3	2.7	3.1	1.6	1.7	1.8	-1.6
Body weight	0.1	0.3	0.6	-0.8	-0.6	-0.3	0.3
Weight adjusted by age	0.1	0.1	0.1	0.3	0.1	0.4	-0.1
Bone surface	0.0	0.0	0.1	0.0	0.0	0.3	-0.0
Bone volume	0.1	0.2	0.4	0.3	0.2	0.4	-0.7
Breakpoint value in progressive ratio session	3.2	3.6	4.3	1.7	1.8	2.1	-1.9
Number of licking bursts	0.9	1.0	1.1	1.0	1.0	1.0	-1.0
Context. condit. distance diff. score	1.2	1.4	1.8	-1.2	-1.3	-1.0	1.1
Locomotion velocity, session 1	0.2	0.2	0.3	-0.3	-0.3	-0.5	0.5
Locomotion distance, session 1	0.6	0.8	1.1	-0.8	-1.0	-0.9	0.9
Locomotion velocity, session 2	1.6	1.9	2.1	-1.4	-1.5	-1.4	1.2
Locomotion distance, session 2	0.4	0.5	0.9	-0.8	-0.9	-0.6	0.5
Locomotion velocity, session 3	2.0	2.3	2.7	-1.5	-1.5	-1.4	1.6
Locomotion distance, session 3	6.3	6.9	7.4	-2.7	-2.5	-2.5	2.7
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	0.1	0.1	-0.0
Stereotopy head waving duration, day 3	0.7	0.8	1.0	0.9	1.0	0.8	-0.9
Locomotion velocity, session 7	0.4	0.5	0.7	-0.8	-0.7	-0.5	0.8
Locomotion distance, session 7	0.7	0.9	1.3	-1.1	-0.8	-0.8	1.0
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	0.4	0.3	0.9	-0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.3	0.3	0.8	-0.4
Locomotion velocity, session 8	0.8	1.0	1.5	-1.1	-1.2	-0.8	0.7
Locomotion distance, session 8	2.8	4.1	5.1	-2.2	-2.2	-1.8	1.9
Degree of sensitization distance	2.2	2.2	2.4	1.4	1.5	1.5	-1.5
Degree of sensitization stereotypy	0.2	0.2	0.8	0.2	0.0	0.9	-0.4
Conditioned locomotion	0.5	0.6	0.9	-0.9	-1.0	-0.7	0.6
Cocaine response after cond. corrected	4.0	4.5	4.9	-2.0	-2.1	-2.2	2.1
Cocaine response after cond. not corrected	3.8	4.2	4.6	-2.0	-2.1	-2.1	2.0
Cocaine response before conditioning	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.2
Saline control response	0.8	1.0	1.4	-1.2	-1.2	-0.6	1.0
Bone: connectivity density	1.3	2.0	2.3	1.4	1.4	1.5	-1.4
Bone: cortical apparent density	0.4	0.6	0.9	-0.7	-0.8	-1.0	0.5
Bone: cortical area	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.0
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.0	0.4	-0.5
Bone: cortical porosity	0.3	0.3	0.5	0.6	0.3	0.5	-0.7
Bone: cortical thickness	0.1	0.2	0.5	0.3	0.2	0.4	-0.7
Bone: cortical thickness	0.4	0.5	1.0	-0.8	-1.0	-0.5	0.3
Bone: cortical tissue density	0.4	0.6	1.0	-0.7	-0.8	-1.0	0.5
Condit. Reinf. active minus inactive responses	3.3	3.7	3.9	2.0	1.9	1.8	-2.0
Condit. Reinf. active-inactive response ratio	1.9	2.1	2.4	1.4	1.3	1.4	-1.6
Condit. Reinf. active responses	1.1	1.4	1.5	1.2	1.2	1.1	-1.2
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.4	-0.4	-0.5	0.4
Incentive salience index mean	2.0	2.4	2.7	1.6	1.5	1.4	-1.6
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	0.5	0.5	-0.6
Condit. Reinf. active minus inactive responses	1.9	2.3	3.6	-1.5	-1.4	-1.9	1.2
Condit. Reinf. active-inactive response ratio	2.6	2.7	4.4	-1.6	-1.6	-2.1	1.1
Condit. Reinf. active responses	0.3	0.4	0.7	-0.7	-0.6	-0.8	0.5
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.6	0.6	0.9	-0.3
Condit. Reinf. lever presses	0.5	0.7	0.8	-0.9	-0.8	-0.9	0.6
Condit. Reinf. lever reinforcers received	0.5	0.7	0.9	-0.9	-0.7	-1.0	0.7
Conditioned reinforcement - actives	2.4	2.4	3.2	-1.8	-1.6	-1.4	1.4
Conditioned reinforcement - inactives	0.6	0.6	1.2	-0.9	-1.1	-0.5	0.4
Conditioned locomotion	1.2	1.4	1.9	-1.4	-1.4	-1.0	0.8
Patch foraging indifference point 0 sec	1.4	2.3	3.3	-1.7	-1.2	-1.3	1.8
Patch foraging indifference point AUC	0.8	0.9	1.3	1.2	0.8	0.7	-1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.4	0.6	-0.3	-0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.6	-0.4	-0.5	0.4
Delay disc. indifference point, 2s delay	0.4	0.5	0.6	0.6	0.8	0.8	-0.6
Delay disc. indifference point, 24s delay	0.9	0.9	1.4	-0.9	-0.9	-1.2	0.8
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.5	0.7	0.4	-0.5
Delay disc. indifference point, 8s delay	0.8	0.8	1.0	0.8	1.0	0.8	-1.0
Indifference point function ln k	3.9	5.4	6.3	-2.5	-2.1	-2.3	2.3
Indifference point function log k	3.9	5.4	6.3	-2.5	-2.1	-2.3	2.3
Patch foraging total patch changes 0 sec	2.0	3.2	4.3	-2.0	-1.5	-1.6	2.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.0	0.0	-0.1	0.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.1	-0.2	0.3	0.1
Patch foraging total patch changes 24 sec	2.6	3.1	3.9	-1.8	-2.0	-1.7	1.6
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.0	0.2	0.1	0.4
Patch foraging time to switch 0 sec	2.5	3.8	4.1	2.0	1.9	2.0	-2.0
Patch foraging water rate 0 sec	1.8	2.9	3.2	-1.8	-1.6	-1.7	1.7
Patch foraging water rate 12 sec	5.3	8.1	9.5	-2.8	-2.8	-3.1	2.7
Patch foraging water rate 18 sec	3.5	4.7	5.2	-2.3	-2.3	-2.1	2.0
Patch foraging water rate 24 sec	1.3	1.9	2.2	-1.5	-1.5	-1.3	1.2
Patch foraging water rate 6 sec	8.3	12.1	12.7	-3.5	-3.3	-3.6	3.6
Seeking ratio, delayed vs. immediate footshock	3.5	4.0	4.8	1.9	2.2	1.8	-2.0
Distance traveled before self-admin	2.1	2.2	2.6	-1.6	-1.4	-1.6	1.3
Distance traveled after self-admin	2.0	2.2	2.7	-1.5	-1.4	-1.6	1.3
Extensor digitorum longus weight	5.5	21.5	27.8	4.5	4.1	5.3	-4.6
Bone: elastic displacement	0.8	0.9	1.5	1.0	1.2	0.5	-0.9
Bone: elastic work	0.2	0.2	0.4	0.6	0.6	0.4	-0.3
Bone: endosteal estimation	1.4	3.2	4.1	-1.7	-1.8	-1.6	2.0
Bone: endosteal perimeter	0.0	0.1	0.3	-0.0	-0.1	0.2	0.5
Epididymis fat weight	0.6	1.3	1.5	1.1	1.1	1.2	-1.1
Delta time in closed arm before/after self-admin	3.7	3.6	3.8	1.8	1.9	2.0	-1.8
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.2	-0.6	-0.5	0.3
Diff in mean of infusions in LGA sessions	0.5	0.5	0.5	0.7	0.7	0.7	-0.7
Delay discount exponential model param	0.2	0.2	0.3	-0.3	-0.6	-0.3	0.5
Extinction: sum of active levers before priming	0.7	0.7	1.0	0.7	0.7	1.0	-1.0
Active lever presses in extinction session 6	2.0	1.9	3.0	1.4	1.7	1.3	-1.2
Bone: final force	1.2	1.9	2.5	-1.4	-1.6	-1.2	1.3
Bone: final moment	1.6	2.6	3.3	-1.6	-1.8	-1.5	1.5
Food consumed during 24 hour testing period	1.1	1.4	1.6	-1.2	-1.1	-1.1	1.2
Glucose	0.3	0.5	0.7	0.8	0.8	0.4	-0.7
Heart weight	0.1	0.1	0.3	-0.4	-0.6	0.2	0.0
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.5
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.3
Intermittent access intake escalation	0.4	0.4	0.7	-0.6	-0.8	-0.6	0.3
Intermittent access intake escalation 2	0.1	0.1	0.3	0.2	-0.0	0.3	-0.5
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.5	1.1	1.0	1.6	-1.1
Intermitt. access day 15 inactive lever presses	1.7	1.9	2.0	1.3	1.3	1.4	-1.4
Intermitt. access escalation Index	0.3	0.3	0.5	-0.4	-0.4	-0.7	0.5
Intermittent access day 1 total infusions	2.1	2.5	3.2	-1.7	-1.8	-1.4	1.3
Intermittent access day 15 total infusions	3.3	3.7	4.7	-2.1	-2.2	-1.8	1.5
Intermittent access terminal intake (last 3 days)	2.0	2.2	3.3	-1.7	-1.8	-1.2	1.0
Intermittent access total infusions	3.3	3.7	4.6	-2.1	-2.1	-1.8	1.6
Intermittent access day 1 locomotion	5.5	5.8	7.1	-2.4	-2.7	-2.3	2.2
Intermittent access day 15 total locomotion	2.7	2.9	3.7	-1.7	-1.9	-1.7	1.5
Intermittent access total locomotion	6.9	7.9	9.7	-2.9	-3.1	-2.6	2.6
Intermittent access standard deviation	1.2	1.3	2.7	-1.2	-1.6	-0.8	0.5
Left kidney weight	0.4	1.0	1.5	-1.2	-1.2	-0.5	0.9
Right kidney weight	0.1	0.3	0.7	-0.6	-0.8	0.2	0.2
Cocaine induced anxiety	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5
Post-drug Anxiety	0.9	1.0	2.1	-1.0	-1.4	-0.5	0.8
Baseline Anxiety	0.1	0.1	0.3	-0.3	-0.5	0.3	0.0
Tail length	3.0	9.0	10.1	-3.1	-2.6	-3.1	3.2
Length with tail	4.3	15.6	17.2	-4.2	-3.6	-4.1	3.9
Length without tail	2.6	5.6	6.9	-2.6	-2.4	-2.3	2.1
Times rat made contact with spout	0.4	0.5	0.7	-0.7	-0.7	-0.4	0.9
Lifetime Intake	2.9	3.3	4.0	-2.0	-2.0	-1.7	1.5
Liver weight, left	0.2	0.3	0.9	-0.5	-0.9	0.1	0.4
Liver weight, right	0.2	0.4	0.8	-0.6	-0.9	-0.3	0.5
Locomotor activity	0.4	0.6	0.9	-0.6	-0.9	-0.6	0.9
Locomotor testing distance	0.1	0.2	0.5	0.5	0.4	0.7	-0.3
Locomotor testing rearing	0.1	0.2	0.4	-0.3	-0.4	-0.1	0.7
Locomotion in novel chamber	0.2	0.3	0.4	-0.6	-0.6	-0.3	0.6
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	0.7	0.6	0.1	-0.6
Fecal boli incidents, locomotor time 1	0.7	0.7	1.0	0.7	1.0	1.0	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.0	-0.0	0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.1	0.7	0.6	1.0	-0.6
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.4	0.2	-0.4	0.3
Total resting periods, locomotor time 1	0.2	0.3	0.5	-0.0	-0.4	-0.7	0.7
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	0.1	0.2	-0.1
Distance moved, locomotor task time 1	0.6	0.6	1.3	-0.8	-1.1	-0.6	0.4
Vertical activity count, locomotor time 1	0.7	0.8	1.2	-0.9	-1.1	-0.7	0.8
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.5	1.1	1.2	1.2	-1.1
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.4	0.3	0.0	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	0.3	0.2	-0.1
Rest time, locomotor task time 2	0.3	0.4	0.7	0.7	0.2	0.8	-0.5
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.1
Vertical activity count, locomotor time 2	0.3	0.3	0.5	-0.7	-0.5	-0.4	0.6
Light reinforcement 1	1.3	2.4	2.8	-1.7	-1.4	-1.6	1.5
Light reinforcement 2	0.0	0.0	0.0	0.1	-0.2	0.2	-0.2
Bone: marrow area	1.5	3.2	4.2	-1.7	-1.8	-1.5	2.0
Bone: maximum diameter	0.4	0.7	1.3	0.9	0.7	1.1	-0.5
Bone: maximum force	0.3	0.5	0.8	-0.7	-0.9	-0.4	0.7
Bone: maximum moment	0.5	0.9	1.3	-1.0	-1.2	-0.8	0.9
Mean time between licks in bursts	0.2	0.3	0.8	0.5	0.3	0.5	-0.9
Mean num. licks in bursts	1.8	2.2	2.9	-1.5	-1.4	-1.3	1.7
Cd content in liver	0.2	0.2	0.3	0.2	0.4	0.4	-0.6
Co content in liver	0.5	0.6	0.8	0.7	0.9	0.5	-0.8
Cu content in liver	0.0	0.0	0.1	-0.3	-0.3	0.0	0.2
Fe content in liver	0.3	0.4	0.6	-0.5	-0.4	-0.8	0.7
K content in liver	7.4	7.3	8.0	-2.8	-2.8	-2.6	2.7
Mg content in liver	2.6	2.7	3.1	-1.7	-1.8	-1.4	1.6
Mn content in liver	0.6	0.7	1.1	-0.8	-0.7	-1.1	0.6
Na content in liver	1.2	1.3	1.5	-1.1	-1.2	-1.1	1.1
Rb content in liver	0.4	0.4	0.6	-0.8	-0.8	-0.6	0.5
Se content in liver	0.5	0.6	1.1	0.6	0.4	1.0	-0.8
Sr content in liver	2.6	2.4	2.6	1.6	1.6	1.4	-1.6
Zn content in liver	0.1	0.1	0.2	0.0	0.0	0.4	-0.3
Bone: minimum diameter	3.0	5.7	7.0	-2.3	-2.5	-2.0	2.6
Time in familiar zone, hab. session 1	2.7	2.5	2.7	-1.6	-1.5	-1.7	1.5
Time in novel zone, hab. session 1	5.9	5.8	6.0	2.4	2.4	2.4	-2.3
Total zone transitions, hab. session 1	0.3	0.4	0.9	0.5	0.5	1.0	-0.6
Total locomotion distance, hab. session 1	0.3	0.5	0.6	-0.8	-0.7	-0.5	0.7
Locomotion velocity, hab. session 1	0.4	0.5	0.7	-0.8	-0.9	-0.6	0.7
Time in familiar zone, hab. session 2	1.9	2.0	3.0	-1.2	-1.1	-1.7	1.5
Time in novel zone, hab. session 2	2.5	2.5	3.9	1.3	1.1	2.0	-1.8
Total zone transitions, hab. session 2	0.7	0.9	1.6	-0.8	-1.3	-0.9	0.7
Total locomotion distance, hab. session 2	0.5	0.7	1.2	-0.8	-1.1	-0.9	0.4
Locomotion velocity, hab. session 2	1.1	1.5	2.3	-1.1	-1.5	-1.3	0.8
Novel to familiar place preference ratio	3.1	3.2	4.0	1.6	1.7	2.0	-1.9
Novelty place preference	3.0	3.0	3.8	1.6	1.6	1.9	-1.8
Time in novel zone, NPP test	3.1	3.2	4.3	1.6	1.6	2.1	-1.9
Total zone transitions, NPP test	1.0	1.4	1.9	-1.2	-1.4	-1.1	1.1
Total locomotion distance, NPP test	0.3	0.5	0.6	-0.7	-0.8	-0.7	0.5
Locomotion velocity, NPP test	1.3	1.8	2.1	-1.4	-1.5	-1.4	1.2
Intraocular pressure	7.2	10.1	11.0	3.2	2.9	3.3	-3.2
Delta distance traveled before/after self-admin	0.5	0.5	0.8	-0.6	-0.6	-0.9	0.8
Delta ambulatory time before/after self-admin	0.7	0.8	0.9	-0.9	-0.8	-0.9	0.9
Parametrial fat weight	0.6	1.1	1.6	0.9	1.0	1.3	-1.0
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.3	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.7	-0.5	-0.6	0.7
Pavlov. Cond. change in total contacts	0.5	0.5	0.7	-0.8	-0.7	-0.8	0.6
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.4
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.5	-0.5	-0.3	0.3
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	0.9	0.8	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	11.7	14.2	14.8	3.8	3.7	3.7	-3.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.4
Pavlov. Cond. response bias	0.5	0.7	0.9	-0.9	-0.8	-0.6	0.9
Pavlov. Cond. lever latency	0.5	0.6	0.9	0.9	0.7	0.9	-0.6
Pavlov. Cond. magazine entry latency	1.1	1.2	1.7	-1.3	-1.1	-0.9	1.0
Pavlov. Cond. change in total contacts	3.3	4.5	4.9	-2.2	-2.1	-2.2	2.0
Pavlov. Cond. index score	1.5	2.0	2.4	-1.6	-1.4	-1.3	1.3
Pavlov. Cond. latency score	1.8	2.3	2.8	-1.7	-1.5	-1.5	1.4
Pavlov. Cond. lever contacts	0.6	0.8	1.0	-0.9	-0.8	-1.0	0.8
Pavlov. Cond. magazine entry number	2.1	2.6	3.0	1.7	1.4	1.6	-1.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.5	0.4	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.5	-1.6	-1.4	-1.3	1.3
Pavlov. Cond. response bias	0.6	0.8	1.0	-1.0	-0.8	-0.9	0.8
Time in closed arm before self-admin	0.4	0.4	0.7	-0.4	-0.9	-0.7	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.2	0.2	-0.2
Time in open arm before self-admin	1.3	1.4	2.7	1.0	1.6	1.1	-0.9
Time in open arm after self-admin	0.5	0.5	0.7	0.7	0.8	0.6	-0.7
Bone: periosteal estimation	0.6	1.2	1.6	-1.0	-1.2	-0.8	1.3
Bone: periosteal perimeter	0.0	0.0	0.1	-0.0	-0.2	0.3	0.2
Bone: post-yield work	1.0	1.3	1.6	1.1	1.3	1.2	-1.0
Progressive ratio test 1 active lever presses	2.1	2.2	2.9	-1.7	-1.6	-1.2	1.3
Progressive ratio test 1 breakpoint	2.9	3.0	3.9	-2.0	-1.9	-1.4	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.8	-0.7	-0.9	-0.4	0.3
Progressive ratio test 2 active lever presses	0.8	0.8	1.2	-1.0	-1.1	-0.7	0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	-0.8	-0.9	-0.4	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.2
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.5	-0.4	-0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.2
Sum of active levers in priming session hrs 5-6	1.6	1.6	2.7	1.2	1.6	0.9	-1.1
Progressive ratio	1.7	2.0	2.7	1.1	1.6	1.3	-1.5
Food seeking constrained by brief footshock	4.5	5.5	6.1	-2.3	-2.5	-2.2	2.4
Seeking ratio, punishment vs. effort	5.3	6.5	7.9	-2.2	-2.8	-2.4	2.7
Retroperitoneal fat weight	1.4	4.5	4.9	2.1	2.1	2.2	-2.0
Reaction time number correct	6.5	9.3	10.6	-3.3	-2.9	-3.2	2.9
Reaction time mean minus median	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.3
Reaction time mean minus median AUC	0.3	0.4	0.5	-0.6	-0.7	-0.6	0.7
Reaction time num false alarms	0.7	1.0	1.1	1.0	1.0	1.0	-1.0
Reaction time num false alarms AUC	1.2	1.7	1.8	1.3	1.3	1.3	-1.3
Reaction time trials correct on left	6.5	9.3	10.6	-3.3	-2.9	-3.2	2.9
Reaction time trials on left	6.6	9.5	10.7	-3.3	-2.9	-3.2	2.9
Reaction time mean	1.8	2.5	3.3	1.7	1.5	1.2	-1.8
Reaction time mean AUC	1.5	2.1	2.6	1.6	1.4	1.0	-1.6
Median of all reaction times	3.0	4.1	5.6	2.2	1.9	1.6	-2.4
Reaction time omissions	0.2	0.2	0.3	-0.4	-0.5	-0.6	0.5
Reaction time false alarm rate	6.0	8.4	8.7	3.0	2.9	2.9	-2.8
Reaction time premature initiation rate	5.5	7.4	7.9	-2.7	-2.7	-2.6	2.8
Reaction time premature initiations	11.7	16.5	17.5	-4.2	-4.0	-4.0	4.1
Std. dev. reaction times	0.1	0.1	0.2	0.4	0.2	0.3	-0.4
Reaction time trials completed	6.6	9.5	10.7	-3.3	-2.9	-3.2	2.9
Reaction time trials AUC	5.7	8.2	9.4	-3.1	-2.7	-3.0	2.6
Run reversals in cocaine runway, females	1.1	1.1	1.6	0.8	0.8	1.3	-1.2
Run reversals in cocaine runway, males	0.3	0.3	0.4	0.7	0.5	0.5	-0.5
Latency to leave start box in cocaine runway	1.1	1.2	1.6	1.3	1.2	0.5	-1.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.5	0.4	0.0	-0.6
Latency to leave start box in cocaine runway, M	1.9	1.9	2.4	1.6	1.5	1.0	-1.3
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.1	-0.1	0.0	-0.4
Total sessions with >9 infusions	1.0	1.1	1.5	-1.2	-1.1	-0.9	0.8
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.0	-0.2	0.3	-0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.1	-0.2	0.1	-0.5
Short access day 1 total infusions	1.9	2.1	2.6	-1.6	-1.6	-1.3	1.1
Short access day 10 total infusions	2.5	2.8	3.6	-1.9	-1.8	-1.4	1.4
Short access total infusions	2.6	3.0	3.5	-1.9	-1.8	-1.6	1.6
Short access day 1 locomotion	0.6	0.7	0.9	-1.0	-0.8	-0.8	0.7
Short access day 10 total locomotion	0.5	0.6	0.7	-0.7	-0.8	-0.8	0.7
Short access total locomotion	4.2	4.3	4.7	-2.0	-2.2	-2.2	2.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.4	-0.2	-0.2	0.0
Compulsive drug intake	0.9	0.9	1.0	1.0	1.0	0.9	-0.8
One hour access (shock baseline)	2.5	2.9	3.8	-1.9	-1.7	-1.7	1.4
Social response proportion	0.6	0.6	0.8	0.8	0.7	0.9	-0.8
Social responses	0.0	0.1	0.2	-0.1	0.1	0.1	0.4
Social time	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Soleus weight	0.8	2.4	3.1	1.6	1.3	1.8	-1.5
Bone: stiffness	0.3	0.5	0.9	-0.8	-1.0	-0.4	0.5
Tibialis anterior weight	2.7	9.1	10.8	3.1	2.8	3.3	-2.8
Time to tail flick, vehicle, before self-admin	5.6	5.7	7.2	-2.7	-2.6	-2.2	2.1
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.5	-1.2	-1.1	-0.6	0.7
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.2	0.4	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	2.3	2.2	2.5	1.6	1.5	1.5	-1.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	0.2	-0.1	0.1
Tibia length	5.1	14.3	15.2	-3.9	-3.9	-3.8	3.5
Ambulatory time before self-admin	0.4	0.4	0.6	-0.8	-0.6	-0.8	0.5
Ambulatory time after self-admin	1.4	1.5	1.9	-1.3	-1.3	-1.4	0.9
Bone: tissue strength	0.8	0.8	1.0	0.9	1.0	0.8	-0.8
Total heroin consumption	0.2	0.2	0.6	0.2	0.4	0.8	-0.4
Bone: trabecular number	0.7	1.2	1.7	1.1	1.0	0.8	-1.3
Bone: trabecular spacing	0.2	0.3	0.4	-0.5	-0.5	-0.5	0.6
Bone: trabecular thickness	0.9	1.1	1.6	1.0	0.9	1.2	-1.1
Bone: trabecular tissue density	0.1	0.1	0.3	0.3	-0.1	0.4	-0.5
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.2	0.1	0.1
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1