Hub : Genes

Hspg2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_063287775.1 0.02 0.02 4.1e-03 0.01 0.01 0.01 0.01 3.0e-02 1.5e-02 6.1e-02 3.5e-02
2 Liver gene expression Hspg2 0.03 0.02 3.3e-04 0.03 0.03 0.03 0.03 2.4e-04 8.5e-04 2.9e-04 1.0e-04
3 IC gene expression Hspg2 0.06 0.04 3.2e-03 0.08 0.05 0.08 0.08 2.3e-04 4.1e-03 2.5e-04 3.8e-04
4 Adipose isoform ratio NM_001427438.1 0.27 0.11 0.0e+00 0.38 0.39 0.39 0.39 2.2e-44 1.5e-46 2.0e-46 1.5e-46
5 Adipose gene expression Hspg2 0.05 0.03 1.1e-08 0.08 0.07 0.07 0.07 3.2e-09 2.1e-08 3.0e-08 1.6e-08
6 Adipose intron excision ratio chr5_155002208_155002585 0.22 0.1 0.0e+00 0.32 0.32 0.32 0.32 6.1e-36 8.0e-36 1.5e-35 2.0e-36
7 Adipose intron excision ratio chr5_155000329_155002585 0.26 0.1 0.0e+00 0.37 0.38 0.38 0.38 1.6e-43 1.5e-44 7.0e-44 6.9e-44
8 Adipose isoform ratio XM_063287775.1 0.27 0.11 0.0e+00 0.38 0.39 0.39 0.39 2.5e-44 2.5e-46 8.9e-46 3.7e-46
9 Adipose intron excision ratio chr5_155000329_155002158 0.18 0.08 0.0e+00 0.21 0.22 0.22 0.21 2.4e-23 1.7e-24 4.4e-24 3.4e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.10.70.8-0.2-0.30.1-0.2-0.20.3-0.1-0.4
Area under the delay curve0.40.40.5-0.5-0.70.60.7-0.7-0.60.7-0.7-0.7
BMI with tail0.10.41.41.20.6-0.4-0.40.50.6-0.50.30.5
BMI without tail1.54.65.82.42.2-2.1-2.12.12.2-2.12.02.0
Body weight1.77.310.33.22.6-3.1-2.62.52.6-2.52.62.4
Weight adjusted by age1.42.12.90.61.7-0.6-1.61.71.6-1.61.51.7
Bone surface0.10.10.40.6-0.1-0.60.1-0.2-0.10.3-0.1-0.4
Bone volume0.10.10.40.6-0.3-0.40.2-0.3-0.20.3-0.1-0.5
Breakpoint value in progressive ratio session1.51.82.21.21.5-0.8-1.41.51.5-1.41.31.5
Number of licking bursts0.00.00.1-0.30.10.1-0.10.10.2-0.20.10.2
Context. condit. distance diff. score0.80.92.11.50.9-0.7-0.91.01.0-0.80.80.8
Locomotion velocity, session 11.61.72.8-0.3-1.40.51.4-1.5-1.41.5-1.4-1.7
Locomotion distance, session 12.43.04.3-0.7-1.81.41.8-1.9-1.92.0-1.8-2.1
Locomotion velocity, session 24.24.95.6-2.3-2.21.92.2-2.4-2.32.2-2.1-2.2
Locomotion distance, session 21.11.52.6-0.1-1.20.51.2-1.4-1.41.4-1.2-1.6
Locomotion velocity, session 31.31.42.4-0.9-1.01.51.2-1.2-1.21.2-1.3-1.2
Locomotion distance, session 30.90.93.11.81.0-0.7-0.90.91.0-0.70.70.6
Stereotopy head waving bouts, day 31.41.62.5-1.6-1.30.81.2-1.4-1.31.3-1.2-1.3
Stereotopy head waving duration, day 30.70.92.8-1.7-0.90.50.8-1.0-0.90.7-0.7-0.7
Locomotion velocity, session 72.42.73.92.01.7-1.5-1.61.71.6-1.51.61.5
Locomotion distance, session 70.40.50.80.90.7-0.8-0.70.80.7-0.70.70.7
Stereotopy head waving bouts, day 70.10.10.70.10.1-0.8-0.30.30.3-0.30.30.3
Stereotopy head waving duration, day 70.10.10.6-0.00.1-0.7-0.30.20.3-0.30.30.3
Locomotion velocity, session 80.91.11.4-0.5-1.20.31.2-1.1-1.11.2-1.2-1.2
Locomotion distance, session 80.10.21.51.20.0-0.20.0-0.0-0.00.2-0.1-0.4
Degree of sensitization distance0.50.52.5-1.6-0.60.40.6-0.5-0.60.4-0.4-0.3
Degree of sensitization stereotypy1.21.32.11.01.0-1.4-1.11.11.2-1.21.11.2
Conditioned locomotion1.21.42.5-1.6-1.11.01.2-1.1-1.21.1-1.2-1.0
Cocaine response after cond. corrected0.30.32.1-1.5-0.10.90.2-0.1-0.20.0-0.20.2
Cocaine response after cond. not corrected0.20.21.0-1.00.20.5-0.10.20.1-0.30.10.5
Cocaine response before conditioning1.31.52.61.61.1-1.3-1.21.11.2-1.11.31.0
Saline control response0.10.20.4-0.2-0.40.10.5-0.5-0.40.5-0.6-0.4
Bone: connectivity density0.20.41.11.00.5-1.0-0.50.40.4-0.40.50.3
Bone: cortical apparent density1.82.53.11.11.7-1.1-1.71.71.7-1.71.61.7
Bone: cortical area0.81.23.92.00.9-1.4-1.00.90.9-0.81.00.6
Bone: cortical porosity1.11.21.8-1.3-1.10.81.1-1.1-1.21.1-1.0-1.0
Bone: cortical porosity1.41.52.5-1.6-1.30.71.2-1.3-1.41.2-1.1-1.1
Bone: cortical thickness0.61.03.11.80.9-0.9-0.90.90.9-0.70.80.6
Bone: cortical thickness0.20.20.50.5-0.40.70.4-0.3-0.20.5-0.4-0.6
Bone: cortical tissue density1.62.22.80.81.6-0.9-1.61.61.6-1.61.51.7
Condit. Reinf. active minus inactive responses0.50.51.5-1.2-0.71.00.6-0.6-0.70.5-0.4-0.4
Condit. Reinf. active-inactive response ratio0.20.31.3-1.2-0.40.60.3-0.3-0.40.1-0.1-0.1
Condit. Reinf. active responses0.20.30.5-0.7-0.60.40.4-0.6-0.60.4-0.2-0.4
Condit. Reinf. inactive responses0.10.10.20.3-0.4-0.30.1-0.5-0.30.3-0.0-0.5
Incentive salience index mean0.30.41.2-0.8-0.61.10.4-0.6-0.60.4-0.2-0.5
Condit. Reinf. lever presses0.00.10.20.4-0.00.4-0.2-0.00.0-0.10.4-0.1
Condit. Reinf. active minus inactive responses0.10.20.30.2-0.20.60.3-0.4-0.40.5-0.5-0.5
Condit. Reinf. active-inactive response ratio0.80.91.6-1.3-0.81.00.9-0.9-0.90.9-1.0-0.8
Condit. Reinf. active responses0.20.32.21.50.2-0.1-0.20.10.10.00.1-0.2
Condit. Reinf. inactive responses1.31.76.92.61.0-1.2-1.11.01.0-0.91.20.6
Condit. Reinf. lever presses0.60.81.60.8-0.80.80.7-0.9-0.91.0-0.7-1.3
Condit. Reinf. lever reinforcers received0.20.22.01.40.2-0.2-0.20.10.10.00.2-0.2
Conditioned reinforcement - actives0.81.31.71.11.1-1.3-1.21.11.1-1.11.31.0
Conditioned reinforcement - inactives0.81.22.31.21.0-1.5-1.01.01.0-1.01.10.9
Conditioned locomotion2.53.23.51.81.9-1.8-1.81.81.8-1.81.81.7
Patch foraging indifference point 0 sec0.10.21.41.20.2-0.7-0.30.30.3-0.10.20.0
Patch foraging indifference point AUC1.31.93.41.91.4-0.9-1.41.51.4-1.21.31.1
Delay disc. indifference point, 0s delay1.21.31.8-0.4-1.20.91.2-1.2-1.11.3-1.3-1.3
Delay disc. indifference point, 16s delay0.00.00.0-0.0-0.00.20.0-0.0-0.00.1-0.0-0.1
Delay disc. indifference point, 2s delay0.20.20.3-0.4-0.50.40.5-0.5-0.50.5-0.6-0.5
Delay disc. indifference point, 24s delay0.10.10.4-0.6-0.30.50.2-0.3-0.30.2-0.1-0.2
Delay disc. indifference point, 4s delay0.40.40.5-0.5-0.70.20.6-0.7-0.60.7-0.7-0.7
Delay disc. indifference point, 8s delay0.40.50.6-0.4-0.70.80.7-0.7-0.70.8-0.8-0.8
Indifference point function ln k3.86.77.8-2.8-2.72.12.6-2.7-2.62.6-2.5-2.6
Indifference point function log k3.86.77.8-2.8-2.72.12.6-2.7-2.62.6-2.5-2.6
Patch foraging total patch changes 0 sec0.10.21.11.00.0-0.5-0.10.10.10.1-0.0-0.2
Patch foraging total patch changes 12 sec2.02.54.62.21.6-1.9-1.61.51.5-1.31.51.2
Patch foraging total patch changes 18 sec1.01.54.12.01.2-1.2-1.11.21.2-0.91.10.7
Patch foraging total patch changes 24 sec0.91.64.42.11.2-1.1-1.11.31.2-1.01.00.9
Patch foraging total patch changes 6 sec3.04.58.12.82.2-2.1-2.12.22.1-1.91.91.7
Patch foraging time to switch 0 sec1.02.02.50.71.5-1.4-1.41.41.4-1.51.51.6
Patch foraging water rate 0 sec1.43.03.7-1.3-1.81.41.8-1.8-1.71.9-1.9-1.9
Patch foraging water rate 12 sec1.53.14.0-0.9-1.81.71.9-1.7-1.71.9-2.0-2.0
Patch foraging water rate 18 sec1.11.72.7-0.4-1.50.71.3-1.5-1.51.5-1.2-1.7
Patch foraging water rate 24 sec2.73.84.9-1.9-2.21.02.0-2.2-2.02.0-1.9-2.0
Patch foraging water rate 6 sec3.14.65.2-1.8-2.21.82.2-2.2-2.22.3-2.3-2.3
Seeking ratio, delayed vs. immediate footshock0.20.30.50.5-0.4-0.20.5-0.4-0.50.6-0.7-0.7
Distance traveled before self-admin4.86.37.12.72.6-2.1-2.52.62.6-2.52.42.5
Distance traveled after self-admin4.96.07.72.82.5-2.5-2.42.52.4-2.32.32.3
Extensor digitorum longus weight0.20.61.30.5-0.60.20.8-0.8-0.81.0-0.9-1.1
Bone: elastic displacement0.00.00.10.4-0.1-0.30.1-0.1-0.20.2-0.1-0.2
Bone: elastic work0.10.10.60.80.1-0.4-0.10.10.10.00.1-0.1
Bone: endosteal estimation0.20.42.10.80.3-1.4-0.50.30.3-0.40.60.2
Bone: endosteal perimeter0.30.51.10.1-0.80.00.7-0.9-0.80.9-0.6-1.1
Epididymis fat weight0.00.10.4-0.7-0.3-0.10.2-0.2-0.20.1-0.20.0
Delta time in closed arm before/after self-admin0.30.30.4-0.6-0.7-0.30.5-0.7-0.60.5-0.3-0.6
Delta time in open arm before/after self-admin0.10.10.2-0.00.30.0-0.30.30.3-0.40.30.4
Diff in mean of infusions in LGA sessions0.00.10.20.20.2-0.4-0.20.20.2-0.20.30.2
Delay discount exponential model param0.30.30.40.50.6-0.4-0.60.60.5-0.60.60.6
Extinction: sum of active levers before priming0.20.20.90.30.3-0.9-0.30.30.2-0.30.30.3
Active lever presses in extinction session 60.10.10.3-0.10.3-0.5-0.20.30.2-0.30.20.3
Bone: final force1.22.04.42.11.4-1.4-1.41.41.3-1.21.31.1
Bone: final moment0.81.34.02.01.1-1.2-1.11.01.0-0.91.00.7
Food consumed during 24 hour testing period1.01.41.70.61.2-1.2-1.21.21.2-1.21.21.3
Glucose2.84.36.21.02.3-1.6-2.12.22.2-2.32.12.5
Heart weight0.91.42.00.81.2-1.0-1.21.21.3-1.31.11.4
Delay discount hyperbolic model param0.40.50.60.60.7-0.6-0.70.70.7-0.70.70.7
Intermittent access intake day 1-15 change0.00.10.20.4-0.40.10.2-0.2-0.20.2-0.0-0.4
Intermittent access intake escalation0.00.10.20.5-0.40.10.2-0.2-0.30.3-0.1-0.4
Intermittent access intake escalation 20.50.50.9-0.2-0.90.70.7-0.8-0.80.7-0.5-0.9
Intermitt. access day 1 inactive lever presses1.35.06.02.42.3-2.2-2.32.22.2-2.12.32.0
Intermitt. access day 15 inactive lever presses0.61.31.51.11.1-1.0-1.11.21.2-1.21.21.2
Intermitt. access escalation Index0.30.41.81.30.4-0.4-0.40.60.6-0.40.30.4
Intermittent access day 1 total infusions6.710.811.73.23.4-3.3-3.33.33.3-3.23.23.2
Intermittent access day 15 total infusions3.24.86.22.52.2-2.2-2.22.22.2-2.12.22.0
Intermittent access terminal intake (last 3 days)2.83.64.92.21.9-1.9-1.91.81.8-1.82.01.7
Intermittent access total infusions5.66.66.82.62.6-2.5-2.62.62.6-2.52.62.5
Intermittent access day 1 locomotion2.02.63.31.61.8-1.8-1.61.51.6-1.51.41.4
Intermittent access day 15 total locomotion0.61.11.91.11.0-1.4-1.01.01.0-1.01.10.9
Intermittent access total locomotion3.33.95.42.32.0-2.1-2.01.91.9-1.91.91.8
Intermittent access standard deviation0.91.93.01.71.3-1.4-1.41.31.3-1.31.51.1
Left kidney weight6.831.834.95.95.5-5.8-5.75.65.6-5.65.85.3
Right kidney weight3.214.416.43.63.7-3.9-3.93.73.7-3.84.13.6
Cocaine induced anxiety0.10.10.20.00.1-0.5-0.30.30.3-0.40.40.4
Post-drug Anxiety0.30.30.5-0.6-0.70.60.6-0.6-0.60.5-0.5-0.5
Baseline Anxiety1.01.21.7-0.7-1.01.31.1-1.1-1.11.1-1.1-1.1
Tail length3.112.115.92.93.4-4.0-3.63.43.4-3.53.73.4
Length with tail2.711.616.93.33.2-4.1-3.43.23.3-3.33.63.1
Length without tail0.62.02.81.41.3-1.7-1.41.31.4-1.41.51.4
Times rat made contact with spout0.40.40.60.40.7-0.3-0.70.70.7-0.70.70.8
Lifetime Intake4.75.75.92.42.4-2.4-2.42.42.4-2.42.42.3
Liver weight, left1.32.25.12.01.2-2.3-1.41.21.2-1.21.51.0
Liver weight, right1.93.44.61.71.7-2.1-1.91.71.8-1.92.01.8
Locomotor activity1.21.86.02.41.2-1.4-1.11.11.2-1.11.20.9
Locomotor testing distance0.40.83.01.70.6-1.2-0.60.60.6-0.60.70.5
Locomotor testing rearing0.61.13.92.00.8-1.5-0.80.70.8-0.80.90.6
Locomotion in novel chamber0.30.42.61.60.4-0.7-0.20.40.5-0.30.00.3
Locomotion in novel chamber post-restriction0.00.00.10.1-0.2-0.20.2-0.2-0.20.1-0.1-0.2
Fecal boli incidents, locomotor time 14.76.88.52.82.6-2.9-2.62.62.5-2.52.52.4
Change in fecal boli incidents, locomotor task5.15.17.9-2.8-2.12.52.1-2.2-2.22.1-2.1-2.0
Time >=10cm from walls, locomotor time 12.72.93.61.51.7-1.3-1.71.81.7-1.91.71.9
Bouts of movement, locomotor time 10.10.10.2-0.50.00.30.2-0.2-0.10.2-0.4-0.1
Total resting periods, locomotor time 10.00.00.2-0.40.10.10.0-0.00.00.0-0.20.1
Rest time, locomotor task time 10.30.40.8-0.90.6-0.8-0.50.40.5-0.60.40.9
Distance moved, locomotor task time 10.60.91.40.3-1.11.21.0-0.9-0.91.0-0.8-1.1
Vertical activity count, locomotor time 10.61.42.30.5-1.31.41.2-1.0-1.11.3-1.1-1.5
Time >=10cm from walls, locomotor time 21.32.02.60.91.6-0.9-1.51.61.5-1.51.31.6
Bouts of movement, locomotor time 20.10.10.7-0.8-0.00.70.10.00.00.0-0.20.1
Total resting periods, locomotor time 20.10.31.4-1.2-0.20.80.3-0.2-0.10.2-0.40.0
Rest time, locomotor task time 20.70.91.6-0.40.9-0.9-0.90.90.9-1.10.81.3
Distance moved, locomotor task time 20.10.10.50.7-0.2-0.20.2-0.2-0.20.1-0.0-0.3
Vertical activity count, locomotor time 20.40.51.00.7-0.80.60.7-0.6-0.70.8-0.5-1.0
Light reinforcement 10.30.71.41.20.8-0.6-0.80.90.8-0.80.80.8
Light reinforcement 20.00.00.10.30.10.30.00.10.10.1-0.2-0.1
Bone: marrow area0.20.41.90.80.3-1.4-0.50.30.3-0.40.60.2
Bone: maximum diameter0.30.62.31.50.5-1.2-0.60.50.5-0.40.70.2
Bone: maximum force0.71.23.92.00.9-1.1-1.00.90.9-0.81.00.6
Bone: maximum moment0.40.73.41.80.6-0.9-0.60.60.6-0.40.70.2
Mean time between licks in bursts0.30.70.8-0.5-0.90.80.9-0.9-0.90.9-0.9-0.9
Mean num. licks in bursts0.20.40.40.70.6-0.7-0.60.60.5-0.60.60.5
Cd content in liver6.37.011.03.32.8-2.4-2.72.72.7-2.42.42.3
Co content in liver0.30.41.41.10.5-1.2-0.50.30.2-0.20.50.1
Cu content in liver0.40.51.0-0.10.7-1.0-0.60.60.7-0.70.60.8
Fe content in liver0.00.00.00.0-0.20.20.1-0.2-0.10.2-0.1-0.2
K content in liver0.00.00.1-0.30.1-0.10.0-0.0-0.1-0.00.00.1
Mg content in liver0.50.50.90.20.8-0.9-0.70.70.7-0.70.60.8
Mn content in liver0.80.91.10.80.9-0.9-1.01.01.0-1.01.01.0
Na content in liver0.10.10.40.60.3-0.2-0.20.00.0-0.10.3-0.0
Rb content in liver3.44.05.51.01.9-2.2-1.92.12.0-2.22.12.3
Se content in liver0.10.10.8-0.90.1-0.3-0.10.00.1-0.20.00.4
Sr content in liver3.02.63.8-0.5-1.71.41.6-1.7-1.71.8-1.6-1.9
Zn content in liver2.83.14.01.42.0-1.7-1.81.81.8-1.81.61.9
Bone: minimum diameter0.71.33.41.20.9-1.9-1.10.80.9-1.01.20.8
Time in familiar zone, hab. session 11.51.51.81.11.3-1.1-1.21.41.3-1.21.01.3
Time in novel zone, hab. session 10.10.10.2-0.4-0.20.10.2-0.3-0.30.2-0.2-0.1
Total zone transitions, hab. session 10.20.20.40.4-0.5-0.40.4-0.4-0.40.5-0.4-0.6
Total locomotion distance, hab. session 10.30.40.80.4-0.7-0.70.5-0.7-0.60.7-0.5-0.9
Locomotion velocity, hab. session 10.60.81.50.0-1.1-0.20.9-1.0-1.01.1-0.8-1.2
Time in familiar zone, hab. session 20.20.20.30.50.5-0.5-0.50.50.5-0.50.50.4
Time in novel zone, hab. session 20.60.61.0-0.9-0.71.00.8-0.7-0.70.7-0.8-0.6
Total zone transitions, hab. session 21.41.83.1-0.0-1.40.91.4-1.4-1.51.6-1.4-1.8
Total locomotion distance, hab. session 22.12.84.2-0.4-1.81.41.7-1.7-1.81.9-1.7-2.1
Locomotion velocity, hab. session 21.72.23.7-0.1-1.61.11.5-1.6-1.61.7-1.5-1.9
Novel to familiar place preference ratio1.01.11.60.21.1-0.8-1.11.11.1-1.21.11.3
Novelty place preference1.51.62.30.41.4-0.9-1.31.31.3-1.41.31.5
Time in novel zone, NPP test1.81.92.70.51.5-1.1-1.41.51.4-1.51.41.7
Total zone transitions, NPP test1.21.82.5-0.4-1.41.11.4-1.4-1.41.5-1.3-1.6
Total locomotion distance, NPP test1.21.62.5-0.4-1.41.01.3-1.4-1.41.4-1.2-1.6
Locomotion velocity, NPP test1.82.53.8-0.5-1.71.41.6-1.7-1.71.8-1.5-2.0
Intraocular pressure0.10.11.11.10.1-0.3-0.20.10.2-0.00.1-0.1
Delta distance traveled before/after self-admin0.20.20.90.60.3-1.0-0.30.30.3-0.30.40.3
Delta ambulatory time before/after self-admin0.00.10.40.2-0.1-0.70.1-0.1-0.10.1-0.1-0.1
Parametrial fat weight0.41.01.8-0.51.1-0.4-1.01.01.0-1.21.01.3
Pavlov. Cond. lever latency1.62.03.40.51.5-1.9-1.31.41.5-1.51.21.6
Pavlov. Cond. magazine entry latency0.00.00.20.4-0.10.10.1-0.0-0.10.1-0.0-0.1
Pavlov. Cond. change in total contacts1.61.72.1-0.7-1.41.41.3-1.4-1.41.4-1.2-1.4
Pavlov. Cond. index score0.40.51.10.0-0.71.10.7-0.7-0.80.7-0.5-0.8
Pavlov. Cond. latency score0.60.81.8-0.1-0.91.30.8-0.8-0.90.9-0.7-1.0
Pavlov. Cond. lever contacts2.42.94.3-1.0-1.82.11.7-1.7-1.81.7-1.5-1.9
Pavlov. Cond. magazine entry number0.30.31.5-1.2-0.40.40.4-0.5-0.40.4-0.5-0.3
Pavlov. Cond. intertrial magazine entries2.52.98.0-2.8-1.61.41.5-1.7-1.61.4-1.6-1.3
Pavlov. Cond. lever-magazine prob. diff.0.60.71.2-0.3-0.91.10.8-0.8-0.90.9-0.7-0.9
Pavlov. Cond. response bias0.30.30.50.3-0.70.60.6-0.6-0.60.6-0.4-0.7
Pavlov. Cond. lever latency0.20.30.6-0.80.3-0.7-0.30.50.5-0.60.40.8
Pavlov. Cond. magazine entry latency1.21.51.8-1.0-1.30.91.2-1.4-1.31.3-1.2-1.4
Pavlov. Cond. change in total contacts0.10.20.50.7-0.20.30.2-0.4-0.40.5-0.2-0.7
Pavlov. Cond. index score0.81.11.9-0.1-1.00.91.0-1.2-1.21.2-1.0-1.4
Pavlov. Cond. latency score1.11.52.2-0.4-1.21.11.2-1.4-1.31.4-1.2-1.5
Pavlov. Cond. lever contacts0.10.21.21.10.00.3-0.0-0.2-0.10.20.0-0.4
Pavlov. Cond. magazine entry number0.20.30.50.10.5-0.4-0.50.60.6-0.60.50.7
Pavlov. Cond. intertrial magazine entries0.10.20.7-0.90.2-0.1-0.30.30.2-0.50.40.6
Pavlov. Cond. lever-magazine prob. diff.0.91.22.0-0.2-1.10.91.0-1.3-1.21.3-1.0-1.4
Pavlov. Cond. response bias0.20.30.60.6-0.30.60.4-0.5-0.50.6-0.4-0.8
Time in closed arm before self-admin3.95.05.72.22.4-1.7-2.32.42.4-2.32.22.3
Time in closed arm after self-admin0.60.61.80.40.6-1.3-0.70.60.7-0.70.80.7
Time in open arm before self-admin1.11.21.4-1.0-1.10.91.1-1.1-1.11.2-1.2-1.1
Time in open arm after self-admin0.70.81.4-1.2-0.81.10.8-0.8-0.80.7-0.8-0.6
Bone: periosteal estimation0.51.12.91.70.7-1.7-0.90.70.7-0.71.00.4
Bone: periosteal perimeter0.30.52.41.50.2-1.1-0.40.20.2-0.10.4-0.1
Bone: post-yield work0.00.00.1-0.1-0.2-0.30.1-0.2-0.20.2-0.0-0.2
Progressive ratio test 1 active lever presses4.45.46.01.92.5-2.4-2.42.32.3-2.32.42.3
Progressive ratio test 1 breakpoint4.96.06.72.12.6-2.6-2.52.42.5-2.52.52.4
Progressive ratio test 1 inactive lever presses2.33.33.81.71.9-1.9-1.91.81.8-1.81.91.7
Progressive ratio test 2 active lever presses6.07.17.62.62.7-2.7-2.82.62.7-2.62.72.5
Progressive ratio test 2 breakpoint6.47.47.92.62.8-2.7-2.82.72.7-2.72.82.6
Progressive ratio test 2 inactive lever presses5.18.310.32.62.9-3.2-2.92.92.9-2.92.92.8
Incentive Sensitization - Responses4.05.66.42.52.3-2.4-2.42.42.4-2.32.52.2
Incentive Sensitization - Breakpoint4.25.46.02.52.3-2.3-2.42.32.3-2.32.42.2
Sum of active levers in priming session hrs 5-60.10.10.2-0.4-0.2-0.20.4-0.3-0.30.3-0.5-0.2
Progressive ratio0.10.10.60.00.3-0.8-0.30.30.3-0.30.30.3
Food seeking constrained by brief footshock1.82.22.90.91.5-1.1-1.61.51.5-1.71.71.7
Seeking ratio, punishment vs. effort0.10.10.10.30.30.2-0.30.30.3-0.40.40.4
Retroperitoneal fat weight0.41.72.50.31.4-0.9-1.41.41.3-1.51.41.6
Reaction time number correct0.61.11.6-1.3-1.10.71.1-1.1-1.11.0-1.0-1.0
Reaction time mean minus median0.61.42.01.11.4-1.0-1.21.31.3-1.21.01.3
Reaction time mean minus median AUC1.33.34.11.52.0-1.5-1.82.01.9-1.91.62.0
Reaction time num false alarms0.00.10.30.5-0.2-0.40.1-0.00.0-0.20.10.2
Reaction time num false alarms AUC0.10.10.20.3-0.5-0.20.4-0.3-0.30.1-0.2-0.1
Reaction time trials correct on left0.61.11.6-1.3-1.10.71.1-1.1-1.11.0-1.0-1.0
Reaction time trials on left0.61.21.6-1.3-1.20.81.1-1.2-1.11.0-1.0-1.0
Reaction time mean0.20.30.50.60.7-0.5-0.60.60.5-0.50.50.5
Reaction time mean AUC0.00.00.10.10.3-0.3-0.20.20.2-0.20.10.2
Median of all reaction times0.00.00.00.10.1-0.1-0.10.10.0-0.10.20.1
Reaction time omissions0.00.00.00.2-0.2-0.00.2-0.1-0.20.1-0.1-0.2
Reaction time false alarm rate0.10.10.50.70.0-0.5-0.10.20.2-0.30.20.3
Reaction time premature initiation rate0.91.31.6-0.9-1.01.01.1-1.1-1.11.2-1.3-1.2
Reaction time premature initiations1.42.42.9-1.4-1.51.31.6-1.6-1.61.7-1.7-1.7
Std. dev. reaction times0.30.50.70.70.9-0.8-0.60.80.7-0.70.50.7
Reaction time trials completed0.61.21.6-1.3-1.20.81.1-1.2-1.11.0-1.0-1.0
Reaction time trials AUC0.40.81.3-1.1-1.00.60.9-1.0-0.90.8-0.9-0.8
Run reversals in cocaine runway, females0.40.40.91.00.5-0.8-0.50.60.6-0.50.50.5
Run reversals in cocaine runway, males2.82.93.61.41.9-1.3-1.71.91.8-1.81.51.9
Latency to leave start box in cocaine runway0.50.50.9-0.9-0.70.70.8-0.8-0.80.6-0.6-0.6
Latency to leave start box in cocaine runway, F0.10.10.1-0.1-0.20.30.3-0.2-0.30.2-0.3-0.2
Latency to leave start box in cocaine runway, M1.31.22.2-1.5-1.20.91.1-1.2-1.21.0-0.9-0.9
Std. dev. time between licks in bursts0.10.20.30.5-0.30.50.3-0.3-0.40.5-0.3-0.6
Total sessions with >9 infusions2.02.43.01.71.6-1.7-1.61.41.5-1.41.61.3
Short access day 1 total inactive lever presses0.10.10.20.3-0.3-0.20.2-0.3-0.30.3-0.2-0.4
Short access day 10 total inactive lever presses0.20.41.51.20.6-0.5-0.60.70.6-0.50.50.4
Short access day 1 total infusions2.23.04.12.01.8-1.9-1.81.61.6-1.61.71.4
Short access day 10 total infusions3.74.75.22.02.3-2.2-2.32.22.2-2.12.22.1
Short access total infusions2.53.23.81.81.8-1.9-1.91.71.8-1.81.91.7
Short access day 1 locomotion0.40.50.90.90.7-0.8-0.70.70.7-0.60.70.6
Short access day 10 total locomotion2.13.95.52.32.0-2.3-1.91.81.9-1.81.91.7
Short access total locomotion3.23.84.62.12.0-2.0-2.01.91.9-1.81.91.8
One hour access (0.3 mA shock)3.84.36.92.62.0-2.1-2.02.12.0-1.92.11.8
Compulsive drug intake1.01.22.61.60.9-0.9-1.01.11.0-1.01.10.9
One hour access (shock baseline)1.01.52.51.61.3-1.1-1.21.21.2-1.11.11.0
Social response proportion0.00.00.1-0.20.0-0.00.0-0.00.0-0.0-0.00.1
Social responses0.20.21.41.20.2-0.4-0.20.20.3-0.30.30.2
Social time0.20.30.5-0.3-0.60.50.6-0.7-0.70.5-0.5-0.5
Soleus weight0.41.12.21.3-0.90.60.9-1.0-1.01.2-1.0-1.5
Bone: stiffness0.81.23.41.90.9-1.2-1.00.91.0-0.91.10.7
Tibialis anterior weight0.10.42.01.4-0.20.00.3-0.3-0.30.6-0.6-0.8
Time to tail flick, vehicle, before self-admin0.40.41.0-1.0-0.60.40.7-0.5-0.60.6-0.7-0.4
Time to tail flick, vehicle, after self-admin0.60.81.3-0.10.9-0.6-1.00.90.9-1.11.01.2
Time to tail flick, test, before self-admin0.10.10.30.30.2-0.6-0.20.30.3-0.20.10.3
Time to tail flick, test, after self-admin0.60.61.50.20.6-1.2-0.80.70.7-0.81.00.8
Delta time to tail flick, vehicle, before/after SA1.71.72.10.91.3-1.1-1.41.31.3-1.41.41.4
Delta time to tail flick, test, before/after SA0.20.20.3-0.5-0.50.50.3-0.5-0.50.3-0.1-0.4
Tibia length0.51.42.41.61.1-1.6-1.21.01.0-1.01.20.9
Ambulatory time before self-admin2.94.45.12.32.2-1.6-2.22.22.1-2.12.12.0
Ambulatory time after self-admin4.04.76.42.52.2-2.3-2.12.12.1-2.12.12.0
Bone: tissue strength0.00.00.30.50.1-0.2-0.1-0.0-0.00.10.1-0.1
Total heroin consumption0.40.40.60.80.8-0.5-0.70.70.7-0.60.60.6
Bone: trabecular number0.30.51.00.1-0.70.40.7-0.8-0.70.9-0.8-1.0
Bone: trabecular spacing0.00.10.5-0.70.00.1-0.1-0.00.1-0.10.00.2
Bone: trabecular thickness0.91.11.91.11.0-1.4-1.01.01.0-1.01.11.0
Bone: trabecular tissue density0.50.80.90.50.9-0.9-0.90.90.9-0.90.90.9
Water consumed over 24 hours0.00.00.0-0.10.0-0.1-0.00.00.0-0.10.10.1
Number of responses in last shaping day0.70.70.90.90.9-0.7-0.90.80.8-0.80.90.8