Hub : Genes

Hspd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Hspd1 0.09 0.06 2.8e-07 0.09 0.08 0.09 0.09 6.6e-08 4.7e-07 1.8e-07 1.7e-07
2 Liver mRNA stability Hspd1 0.2 0.1 0.0e+00 0.18 0.17 0.17 0.18 8.4e-20 1.3e-18 1.1e-18 1.6e-19
3 Adipose gene expression Hspd1 0.03 0.02 7.0e-04 0.02 0.02 0.01 0.01 4.4e-03 3.6e-03 1.7e-02 1.3e-02
4 pVTA gene expression Hspd1 0.32 0.13 0.0e+00 0.16 0.32 0.32 0.32 1.3e-12 5.6e-26 1.6e-26 8.8e-27
5 NAcc mRNA stability Hspd1 0.08 0.05 7.0e-09 0.03 0.04 0.04 0.04 4.5e-05 2.2e-07 1.5e-06 5.7e-07
6 PL gene expression Hspd1 0.13 0.07 2.2e-10 0.06 0.08 0.08 0.08 1.9e-07 5.5e-09 2.0e-09 9.5e-09
7 Liver gene expression Hspd1 0.06 0.04 1.5e-06 0.01 0.04 0.03 0.04 3.6e-02 3.0e-05 9.5e-05 4.3e-05
8 IC gene expression Hspd1 0.32 0.14 1.6e-10 0.13 0.19 0.15 0.17 2.9e-06 2.2e-08 9.4e-07 1.8e-07
9 NAcc gene expression Hspd1 0.2 0.11 0.0e+00 0.11 0.16 0.14 0.16 1.7e-16 6.6e-24 4.8e-21 3.0e-24
10 BLA gene expression Hspd1 0.17 0.1 2.0e-06 0.03 0.1 0.06 0.08 1.3e-02 7.2e-06 3.2e-04 3.6e-05
11 NAcc isoform ratio NM_022229.2 0.02 0.02 4.7e-03 0.01 0 0.01 0.01 1.5e-02 1.6e-01 1.6e-02 2.7e-02
12 Brain gene expression Hspd1 0.19 0.09 0.0e+00 0.15 0.19 0.2 0.2 4.6e-14 1.7e-17 7.6e-19 3.3e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density3.35.812.8-3.2-3.2-3.6-3.3-1.6-2.6-2.2-1.8-1.9-1.6-0.4-1.1
Area under the delay curve0.30.41.00.70.7-0.0-0.20.7-0.2-0.5-0.5-0.6-0.6-0.7-1.0
BMI with tail1.96.717.24.14.13.83.22.32.32.01.51.51.2-0.20.8
BMI without tail0.41.43.00.80.81.51.5-0.31.71.41.31.31.10.90.3
Body weight0.52.05.6-2.4-2.4-1.3-0.8-2.30.40.40.60.71.01.60.3
Weight adjusted by age0.91.32.4-1.1-1.1-1.6-1.5-0.0-1.4-1.3-1.2-1.1-1.1-0.6-0.7
Bone surface2.95.311.7-3.2-3.2-3.4-3.1-1.6-2.5-2.1-1.6-1.7-1.5-0.3-0.7
Bone volume3.56.313.7-3.1-3.1-3.7-3.4-1.3-2.9-2.5-2.1-2.2-1.9-0.7-1.3
Breakpoint value in progressive ratio session0.30.30.6-0.1-0.1-0.7-0.70.5-0.8-0.7-0.8-0.6-0.6-0.5-0.2
Number of licking bursts0.30.41.31.01.00.40.11.2-0.3-0.3-0.5-0.4-0.5-0.8-0.3
Context. condit. distance diff. score1.41.73.81.01.01.71.7-0.22.01.51.41.41.30.90.2
Locomotion velocity, session 10.20.20.60.70.70.60.50.60.30.0-0.0-0.2-0.4-0.5-0.8
Locomotion distance, session 10.10.10.50.10.10.50.5-0.00.70.40.40.30.20.2-0.4
Locomotion velocity, session 20.20.30.60.60.60.40.20.6-0.0-0.3-0.3-0.4-0.6-0.7-0.8
Locomotion distance, session 20.10.10.20.30.30.40.40.10.40.30.30.30.30.10.2
Locomotion velocity, session 31.11.31.9-0.7-0.70.60.9-1.31.11.31.31.31.31.41.3
Locomotion distance, session 30.20.20.4-0.1-0.10.40.5-0.40.60.50.50.50.50.50.1
Stereotopy head waving bouts, day 31.51.83.20.80.81.71.8-0.31.61.61.51.41.41.01.1
Stereotopy head waving duration, day 31.01.22.0-0.1-0.11.01.2-0.91.41.31.41.31.31.20.8
Locomotion velocity, session 70.30.30.90.60.60.2-0.00.6-0.6-0.5-0.5-0.7-0.9-0.8-0.4
Locomotion distance, session 70.10.10.30.30.3-0.1-0.20.3-0.5-0.3-0.3-0.3-0.4-0.40.2
Stereotopy head waving bouts, day 70.20.30.5-0.3-0.3-0.4-0.50.2-0.7-0.6-0.5-0.6-0.7-0.5-0.5
Stereotopy head waving duration, day 70.10.10.4-0.7-0.7-0.10.1-0.60.20.20.30.10.10.3-0.1
Locomotion velocity, session 80.91.12.40.80.8-0.1-0.41.3-0.7-1.0-1.1-1.2-1.4-1.4-1.6
Locomotion distance, session 80.81.22.80.80.81.51.5-0.01.71.21.21.11.00.60.2
Degree of sensitization distance0.80.81.80.20.2-0.8-1.00.7-1.3-1.1-1.1-1.1-1.1-1.0-0.2
Degree of sensitization stereotypy0.70.71.1-0.5-0.5-0.9-0.90.3-1.1-1.0-0.9-1.0-1.0-0.8-0.8
Conditioned locomotion0.50.51.4-1.0-1.0-1.2-1.1-0.3-0.8-0.6-0.6-0.4-0.2-0.00.2
Cocaine response after cond. corrected3.94.76.8-0.7-0.7-2.3-2.51.1-2.5-2.6-2.5-2.5-2.5-2.1-2.5
Cocaine response after cond. not corrected4.65.47.8-1.2-1.2-2.7-2.80.7-2.7-2.8-2.6-2.6-2.6-2.0-2.6
Cocaine response before conditioning0.20.20.4-0.1-0.10.40.5-0.40.60.60.60.50.50.50.3
Saline control response0.50.71.20.10.10.80.9-0.51.11.01.01.01.10.90.8
Bone: connectivity density2.03.16.4-2.1-2.1-2.5-2.4-0.8-2.1-1.8-1.5-1.6-1.5-0.6-1.0
Bone: cortical apparent density2.43.38.62.92.92.72.32.01.61.20.80.90.6-0.40.4
Bone: cortical area0.10.10.3-0.6-0.6-0.4-0.3-0.3-0.3-0.1-0.1-0.10.00.10.5
Bone: cortical porosity1.71.86.2-2.5-2.5-1.7-1.3-1.9-0.5-0.4-0.1-0.20.10.8-0.2
Bone: cortical porosity2.62.89.5-3.1-3.1-2.2-1.7-2.3-0.8-0.5-0.2-0.30.11.0-0.1
Bone: cortical thickness0.61.02.11.41.41.41.30.80.90.80.60.70.60.10.9
Bone: cortical thickness1.41.64.41.81.80.5-0.12.1-1.0-0.8-1.1-1.1-1.2-1.7-0.4
Bone: cortical tissue density2.53.48.72.92.92.82.42.01.61.20.80.90.7-0.40.4
Condit. Reinf. active minus inactive responses1.11.32.00.20.2-1.0-1.21.1-1.3-1.3-1.4-1.3-1.3-1.3-0.9
Condit. Reinf. active-inactive response ratio0.70.81.30.20.2-0.6-0.80.8-1.0-1.0-1.1-1.1-1.1-1.1-0.8
Condit. Reinf. active responses1.62.03.4-0.2-0.2-1.6-1.80.9-1.9-1.7-1.8-1.6-1.5-1.4-1.0
Condit. Reinf. inactive responses0.40.50.9-0.1-0.1-0.8-1.00.5-0.9-0.9-0.9-0.8-0.7-0.6-0.5
Incentive salience index mean2.12.64.20.30.3-1.4-1.81.5-2.0-2.0-2.0-1.9-1.9-1.8-1.2
Condit. Reinf. lever presses0.81.12.2-0.1-0.1-1.1-1.20.7-1.5-1.3-1.3-1.2-1.1-1.0-0.4
Condit. Reinf. active minus inactive responses3.74.88.6-1.1-1.1-2.8-2.90.7-2.9-2.6-2.5-2.4-2.2-1.8-1.6
Condit. Reinf. active-inactive response ratio2.63.04.70.00.0-1.7-1.91.3-2.2-2.1-2.1-2.0-2.0-1.9-1.7
Condit. Reinf. active responses3.24.58.3-0.5-0.5-2.4-2.71.1-2.9-2.6-2.6-2.4-2.3-2.0-1.6
Condit. Reinf. inactive responses0.40.50.9-0.3-0.3-0.8-0.90.3-0.9-0.9-0.8-0.8-0.8-0.6-0.6
Condit. Reinf. lever presses2.12.95.01.31.3-0.6-1.12.2-1.8-1.8-2.0-1.9-2.0-2.2-1.5
Condit. Reinf. lever reinforcers received3.75.19.2-0.4-0.4-2.4-2.71.3-3.0-2.8-2.8-2.6-2.5-2.2-1.8
Conditioned reinforcement - actives0.40.71.5-0.1-0.10.60.8-0.71.21.01.01.11.01.00.4
Conditioned reinforcement - inactives0.00.10.3-0.2-0.2-0.1-0.0-0.50.20.10.20.10.00.3-0.4
Conditioned locomotion0.10.20.40.70.70.40.40.30.30.30.20.40.40.20.5
Patch foraging indifference point 0 sec1.52.75.41.31.3-0.3-0.82.3-1.8-1.7-1.9-1.8-2.0-2.2-1.2
Patch foraging indifference point AUC0.10.10.2-0.3-0.3-0.4-0.4-0.2-0.4-0.3-0.2-0.4-0.2-0.2-0.3
Delay disc. indifference point, 0s delay0.91.03.21.81.81.20.91.40.50.2-0.0-0.0-0.2-0.7-0.5
Delay disc. indifference point, 16s delay0.30.30.80.30.3-0.3-0.40.5-0.4-0.6-0.6-0.6-0.6-0.6-0.9
Delay disc. indifference point, 2s delay1.61.84.61.81.80.2-0.32.2-0.8-1.0-1.3-1.1-1.2-1.7-1.3
Delay disc. indifference point, 24s delay0.30.40.90.50.50.80.8-0.11.00.70.70.60.60.4-0.1
Delay disc. indifference point, 4s delay0.40.41.21.11.10.70.40.90.4-0.0-0.2-0.2-0.3-0.6-0.9
Delay disc. indifference point, 8s delay0.20.20.4-0.5-0.5-0.6-0.5-0.3-0.4-0.4-0.3-0.4-0.4-0.1-0.6
Indifference point function ln k0.81.54.21.61.60.3-0.02.1-0.8-0.9-1.2-0.9-1.3-1.4-0.7
Indifference point function log k0.81.54.21.61.60.3-0.02.1-0.8-0.9-1.2-0.9-1.3-1.4-0.7
Patch foraging total patch changes 0 sec1.32.55.41.51.5-0.1-0.62.3-1.5-1.5-1.7-1.6-1.8-2.1-1.2
Patch foraging total patch changes 12 sec0.91.12.20.80.8-0.3-0.71.5-1.2-1.1-1.2-1.2-1.2-1.4-0.7
Patch foraging total patch changes 18 sec0.50.82.41.51.50.90.61.3-0.3-0.2-0.3-0.5-0.7-1.0-0.3
Patch foraging total patch changes 24 sec0.00.10.2-0.3-0.3-0.2-0.2-0.1-0.2-0.2-0.1-0.3-0.2-0.2-0.4
Patch foraging total patch changes 6 sec0.61.01.90.70.7-0.2-0.51.3-1.1-1.0-1.1-1.2-1.2-1.4-1.0
Patch foraging time to switch 0 sec0.71.52.6-0.9-0.90.50.8-1.61.41.31.51.31.41.50.9
Patch foraging water rate 0 sec0.20.30.8-0.0-0.0-0.6-0.70.5-0.9-0.7-0.7-0.7-0.5-0.6-0.2
Patch foraging water rate 12 sec1.43.05.51.31.3-0.6-1.22.3-1.8-1.8-2.0-2.0-2.0-2.3-1.4
Patch foraging water rate 18 sec0.60.91.4-0.1-0.1-0.9-1.20.9-1.0-1.1-1.2-1.1-0.9-1.0-1.1
Patch foraging water rate 24 sec0.10.20.4-0.6-0.60.00.1-0.60.50.40.40.40.50.5-0.1
Patch foraging water rate 6 sec0.00.10.20.20.2-0.0-0.20.5-0.1-0.1-0.2-0.20.0-0.4-0.3
Seeking ratio, delayed vs. immediate footshock0.81.02.3-1.4-1.4-1.5-1.4-0.6-1.0-0.9-0.8-0.6-0.6-0.0-0.3
Distance traveled before self-admin0.70.92.3-1.4-1.4-1.5-1.3-0.8-0.8-0.7-0.6-0.5-0.30.2-0.2
Distance traveled after self-admin0.20.31.01.01.00.30.00.9-0.1-0.2-0.3-0.3-0.2-0.6-0.4
Extensor digitorum longus weight1.45.510.82.32.33.33.20.22.92.62.42.32.11.31.5
Bone: elastic displacement0.60.71.91.11.10.1-0.21.4-0.6-0.6-0.8-0.7-0.7-1.1-0.6
Bone: elastic work0.60.81.7-0.8-0.8-1.3-1.3-0.1-1.2-1.0-0.9-0.9-0.7-0.5-0.6
Bone: endosteal estimation2.14.710.3-3.1-3.1-3.2-2.9-1.5-2.2-1.9-1.5-1.5-1.2-0.2-1.2
Bone: endosteal perimeter1.73.78.3-2.9-2.9-2.9-2.5-1.6-2.1-1.6-1.2-1.3-1.1-0.0-0.4
Epididymis fat weight0.51.64.3-1.4-1.4-0.20.2-2.11.01.11.31.21.51.70.7
Delta time in closed arm before/after self-admin0.10.10.50.20.20.40.4-0.10.10.40.40.20.30.10.7
Delta time in open arm before/after self-admin3.33.37.3-2.1-2.1-2.7-2.5-0.7-2.1-1.9-1.6-1.6-1.4-0.6-1.0
Diff in mean of infusions in LGA sessions0.91.01.60.10.1-0.8-1.00.9-1.3-1.2-1.3-1.2-1.3-1.2-0.9
Delay discount exponential model param0.30.41.0-0.7-0.70.00.2-0.70.20.50.50.50.60.71.0
Extinction: sum of active levers before priming0.10.10.4-0.6-0.6-0.4-0.2-0.4-0.00.10.10.20.30.40.4
Active lever presses in extinction session 61.21.22.0-0.2-0.2-1.4-1.40.7-1.3-1.4-1.4-1.1-1.1-0.8-0.9
Bone: final force1.11.74.6-2.2-2.2-1.0-0.5-2.00.30.50.70.81.11.51.0
Bone: final moment1.01.73.8-1.9-1.9-0.7-0.2-2.00.50.70.91.01.31.61.2
Food consumed during 24 hour testing period0.10.20.3-0.4-0.4-0.00.1-0.50.50.40.40.40.50.5-0.1
Glucose1.72.74.40.50.51.61.8-0.92.12.01.92.02.11.71.6
Heart weight0.10.20.4-0.4-0.4-0.6-0.60.1-0.7-0.5-0.5-0.6-0.4-0.5-0.3
Delay discount hyperbolic model param0.30.41.0-0.8-0.8-0.00.2-0.80.20.50.60.60.60.71.0
Intermittent access intake day 1-15 change0.40.81.80.80.81.21.10.31.41.10.90.91.00.40.3
Intermittent access intake escalation0.51.12.21.11.11.51.30.41.51.10.91.01.10.40.3
Intermittent access intake escalation 20.10.10.3-0.1-0.10.30.3-0.10.60.50.40.40.60.30.2
Intermitt. access day 1 inactive lever presses0.93.27.02.12.12.62.40.72.01.91.61.61.50.61.3
Intermitt. access day 15 inactive lever presses0.20.41.00.80.81.00.90.20.80.70.60.50.50.20.1
Intermitt. access escalation Index1.21.73.1-1.3-1.30.30.7-1.71.51.31.51.41.61.70.8
Intermittent access day 1 total infusions0.10.20.6-0.3-0.3-0.8-0.7-0.1-0.5-0.4-0.4-0.2-0.20.0-0.1
Intermittent access day 15 total infusions0.40.51.10.80.80.90.80.31.00.80.60.80.90.40.3
Intermittent access terminal intake (last 3 days)0.30.40.90.90.90.80.70.60.80.60.40.60.70.20.2
Intermittent access total infusions0.00.10.10.30.30.10.10.20.30.20.10.30.40.20.2
Intermittent access day 1 locomotion0.10.10.20.30.3-0.3-0.30.4-0.3-0.4-0.4-0.3-0.3-0.2-0.3
Intermittent access day 15 total locomotion0.10.20.40.30.3-0.6-0.60.5-0.5-0.6-0.6-0.4-0.4-0.3-0.3
Intermittent access total locomotion0.10.10.30.60.60.10.00.40.1-0.0-0.10.10.1-0.10.0
Intermittent access standard deviation0.10.30.80.90.90.60.40.70.30.30.10.20.3-0.20.3
Left kidney weight0.10.30.9-0.4-0.4-0.8-0.70.0-0.3-0.6-0.6-0.5-0.5-0.3-0.9
Right kidney weight0.10.61.8-0.7-0.7-0.9-0.90.0-0.5-0.8-0.7-0.8-0.7-0.6-1.3
Cocaine induced anxiety0.10.20.4-0.5-0.50.10.2-0.60.50.30.40.10.20.2-0.5
Post-drug Anxiety0.10.10.4-0.5-0.50.10.2-0.70.30.30.40.20.30.40.1
Baseline Anxiety0.10.10.3-0.5-0.5-0.4-0.3-0.1-0.6-0.3-0.3-0.1-0.30.10.6
Tail length3.814.848.7-7.0-7.0-5.2-3.9-5.2-1.7-1.4-0.5-0.5-0.02.3-0.4
Length with tail4.117.958.3-7.6-7.6-5.8-4.4-5.7-1.9-1.5-0.6-0.50.12.6-0.1
Length without tail1.55.012.5-3.5-3.5-3.5-3.0-2.1-2.0-1.5-1.1-1.1-0.60.4-0.3
Times rat made contact with spout0.40.50.7-0.4-0.40.40.5-0.80.80.80.80.80.80.90.5
Lifetime Intake0.30.30.60.60.60.60.60.20.80.60.50.60.70.40.3
Liver weight, left2.43.911.7-3.4-3.4-1.7-0.9-3.30.30.51.00.91.22.20.9
Liver weight, right0.40.72.2-1.5-1.5-1.1-0.9-1.2-0.5-0.2-0.0-0.20.10.4-0.1
Locomotor activity0.00.10.2-0.4-0.4-0.4-0.4-0.3-0.2-0.1-0.0-0.10.10.00.1
Locomotor testing distance0.20.41.10.00.0-0.6-0.80.5-1.0-0.7-0.8-0.9-0.6-0.8-0.2
Locomotor testing rearing0.10.10.3-0.6-0.6-0.4-0.3-0.5-0.20.00.1-0.00.20.20.2
Locomotion in novel chamber0.70.92.81.71.71.00.51.7-0.1-0.1-0.3-0.2-0.3-0.90.0
Locomotion in novel chamber post-restriction0.40.71.51.01.01.21.20.21.00.90.80.80.60.40.6
Fecal boli incidents, locomotor time 12.53.65.7-1.5-1.5-2.4-2.40.1-2.2-2.2-2.0-2.0-2.0-1.3-1.8
Change in fecal boli incidents, locomotor task0.30.30.60.70.70.60.60.40.50.40.30.50.40.30.7
Time >=10cm from walls, locomotor time 13.53.76.00.40.4-1.3-1.81.5-2.4-2.2-2.2-2.4-2.4-2.4-2.1
Bouts of movement, locomotor time 10.50.61.0-0.2-0.2-0.7-0.80.5-1.0-0.9-0.9-1.0-0.9-0.9-0.7
Total resting periods, locomotor time 10.60.71.30.60.6-0.1-0.41.1-0.8-0.8-0.9-0.9-1.0-1.2-0.9
Rest time, locomotor task time 10.10.10.20.10.10.30.3-0.10.30.40.40.20.40.10.3
Distance moved, locomotor task time 10.40.71.1-0.2-0.2-0.9-0.90.4-0.8-1.0-1.0-0.9-1.0-0.7-1.0
Vertical activity count, locomotor time 10.20.40.60.00.00.60.7-0.50.80.70.70.70.60.70.4
Time >=10cm from walls, locomotor time 22.94.36.6-0.1-0.1-1.9-2.31.4-2.5-2.4-2.4-2.6-2.3-2.3-2.4
Bouts of movement, locomotor time 20.81.33.01.31.30.1-0.31.7-0.8-0.9-1.1-1.1-1.2-1.6-1.2
Total resting periods, locomotor time 20.81.33.11.31.30.1-0.31.8-0.9-0.9-1.1-1.2-1.2-1.6-1.1
Rest time, locomotor task time 20.50.71.1-0.0-0.00.80.9-0.60.91.01.10.91.00.80.8
Distance moved, locomotor task time 21.11.32.00.10.1-1.0-1.20.8-1.3-1.4-1.4-1.4-1.4-1.3-1.4
Vertical activity count, locomotor time 20.10.20.60.80.80.30.10.60.0-0.1-0.2-0.2-0.2-0.4-0.4
Light reinforcement 11.12.64.82.02.02.22.01.01.91.61.21.51.40.60.9
Light reinforcement 20.40.61.70.70.7-0.4-0.61.3-0.9-0.9-1.0-0.7-0.7-0.9-0.2
Bone: marrow area2.04.49.7-3.0-3.0-3.1-2.8-1.5-2.2-1.8-1.5-1.5-1.2-0.2-1.1
Bone: maximum diameter0.50.91.8-1.1-1.1-1.3-1.2-0.3-1.1-1.0-0.8-0.8-0.8-0.4-0.4
Bone: maximum force1.32.27.5-2.7-2.7-1.8-1.3-2.2-0.4-0.10.20.20.61.20.5
Bone: maximum moment1.01.85.8-2.4-2.4-1.5-1.0-2.0-0.20.10.30.40.71.20.6
Mean time between licks in bursts0.61.42.10.50.51.31.4-0.61.41.41.41.41.41.11.2
Mean num. licks in bursts0.30.51.4-0.9-0.9-0.10.2-1.20.70.60.70.70.70.90.4
Cd content in liver0.20.20.9-0.6-0.6-0.4-0.2-0.5-0.20.10.10.20.40.40.9
Co content in liver0.20.30.5-0.1-0.10.50.6-0.40.70.60.60.60.60.60.4
Cu content in liver0.20.20.4-0.3-0.3-0.6-0.60.2-0.5-0.6-0.6-0.5-0.4-0.4-0.5
Fe content in liver0.70.92.2-1.4-1.4-1.5-1.3-0.8-0.7-0.8-0.6-0.6-0.40.1-0.6
K content in liver0.20.20.40.10.1-0.2-0.30.3-0.4-0.4-0.4-0.5-0.6-0.5-0.6
Mg content in liver0.30.30.5-0.3-0.3-0.5-0.60.2-0.6-0.6-0.6-0.6-0.7-0.5-0.7
Mn content in liver0.91.02.51.61.61.61.40.90.80.70.60.60.3-0.10.5
Na content in liver1.11.22.0-0.7-0.7-1.4-1.40.2-1.3-1.3-1.2-1.2-1.2-0.9-1.2
Rb content in liver1.51.72.5-0.1-0.1-1.1-1.31.0-1.5-1.6-1.6-1.6-1.6-1.4-1.5
Se content in liver0.10.10.30.30.3-0.3-0.40.5-0.4-0.4-0.5-0.4-0.3-0.4-0.2
Sr content in liver2.01.72.9-1.0-1.00.40.8-1.61.31.41.51.51.71.71.3
Zn content in liver0.20.20.5-0.7-0.7-0.2-0.0-0.70.40.30.30.40.40.60.2
Bone: minimum diameter0.30.61.3-1.1-1.1-1.2-1.0-0.5-0.8-0.7-0.6-0.5-0.4-0.1-0.2
Time in familiar zone, hab. session 10.60.61.0-0.5-0.50.50.8-1.01.00.81.00.80.80.90.2
Time in novel zone, hab. session 10.50.50.90.50.5-0.4-0.70.9-1.0-0.8-0.9-0.8-0.8-0.9-0.2
Total zone transitions, hab. session 10.50.71.40.10.1-0.5-0.70.7-0.9-1.0-1.0-1.1-1.2-1.0-1.0
Total locomotion distance, hab. session 11.11.62.4-0.0-0.0-1.0-1.31.1-1.5-1.5-1.5-1.5-1.5-1.4-1.1
Locomotion velocity, hab. session 10.40.61.1-0.6-0.6-0.9-1.00.3-0.9-0.9-0.9-0.9-0.7-0.6-0.6
Time in familiar zone, hab. session 20.50.51.51.21.21.00.71.00.30.20.10.0-0.1-0.4-0.2
Time in novel zone, hab. session 20.20.20.6-0.8-0.8-0.5-0.4-0.70.00.10.10.10.30.50.3
Total zone transitions, hab. session 20.40.51.0-0.9-0.90.20.4-1.00.80.70.80.70.80.90.4
Total locomotion distance, hab. session 20.50.61.4-1.2-1.2-0.20.0-1.10.70.60.70.60.80.90.4
Locomotion velocity, hab. session 20.70.92.1-1.5-1.5-0.20.0-1.40.80.70.80.70.91.20.5
Novel to familiar place preference ratio0.60.71.8-1.1-1.1-1.3-1.3-0.4-0.8-0.7-0.6-0.5-0.3-0.0-0.3
Novelty place preference0.60.71.7-1.2-1.2-1.3-1.2-0.5-0.7-0.6-0.6-0.5-0.20.1-0.3
Time in novel zone, NPP test0.50.61.5-1.0-1.0-1.2-1.2-0.3-0.7-0.7-0.6-0.5-0.3-0.1-0.4
Total zone transitions, NPP test0.00.10.10.20.20.40.30.20.40.20.20.20.20.0-0.0
Total locomotion distance, NPP test0.10.20.70.60.60.2-0.00.9-0.1-0.2-0.3-0.3-0.2-0.5-0.2
Locomotion velocity, NPP test0.10.10.30.50.50.40.20.60.20.1-0.10.00.1-0.20.0
Intraocular pressure1.31.84.22.02.02.11.81.21.51.00.80.80.6-0.10.1
Delta distance traveled before/after self-admin0.70.82.21.51.51.31.01.10.70.50.30.30.3-0.4-0.1
Delta ambulatory time before/after self-admin0.50.72.01.41.41.10.81.20.50.40.10.30.2-0.30.0
Parametrial fat weight0.61.52.40.30.31.31.4-0.71.51.51.51.41.51.11.1
Pavlov. Cond. lever latency1.51.93.90.20.21.51.7-1.02.01.71.71.61.51.40.4
Pavlov. Cond. magazine entry latency1.92.53.80.20.2-1.3-1.71.4-1.8-1.9-2.0-1.9-1.8-1.8-1.7
Pavlov. Cond. change in total contacts3.33.55.30.80.8-1.2-1.72.1-2.3-2.2-2.3-2.2-2.2-2.3-1.4
Pavlov. Cond. index score1.41.72.80.10.1-1.2-1.51.2-1.7-1.6-1.7-1.5-1.4-1.4-1.0
Pavlov. Cond. latency score1.82.33.9-0.1-0.1-1.6-1.81.2-2.0-1.8-1.9-1.7-1.6-1.6-1.0
Pavlov. Cond. lever contacts1.41.73.20.20.2-1.2-1.51.3-1.8-1.6-1.7-1.5-1.4-1.5-0.6
Pavlov. Cond. magazine entry number1.41.82.8-0.1-0.11.31.5-1.11.61.61.71.61.51.41.3
Pavlov. Cond. intertrial magazine entries0.30.41.2-1.1-1.1-0.7-0.4-1.10.10.10.20.20.40.70.1
Pavlov. Cond. lever-magazine prob. diff.1.61.93.10.30.3-1.1-1.41.4-1.7-1.7-1.8-1.6-1.6-1.6-1.1
Pavlov. Cond. response bias1.11.42.20.20.2-1.0-1.31.1-1.4-1.4-1.5-1.4-1.4-1.3-1.0
Pavlov. Cond. lever latency1.42.03.4-1.1-1.10.40.8-1.71.51.41.51.61.81.81.3
Pavlov. Cond. magazine entry latency0.00.00.10.20.20.20.20.1-0.0-0.1-0.0-0.2-0.3-0.2-0.4
Pavlov. Cond. change in total contacts2.03.25.20.90.9-0.9-1.32.0-2.0-2.0-2.1-2.1-2.3-2.3-1.7
Pavlov. Cond. index score1.11.42.40.80.8-0.4-0.71.4-1.2-1.3-1.3-1.4-1.5-1.6-1.3
Pavlov. Cond. latency score0.91.22.00.70.7-0.4-0.71.2-1.1-1.2-1.2-1.3-1.4-1.4-1.2
Pavlov. Cond. lever contacts2.33.15.31.21.2-0.7-1.22.1-1.9-1.9-2.0-2.0-2.2-2.3-1.6
Pavlov. Cond. magazine entry number0.30.30.60.20.20.50.6-0.20.70.70.60.70.80.60.5
Pavlov. Cond. intertrial magazine entries0.10.10.40.50.50.0-0.10.7-0.1-0.2-0.3-0.1-0.0-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.1.21.52.70.80.8-0.4-0.71.5-1.3-1.3-1.4-1.4-1.6-1.6-1.3
Pavlov. Cond. response bias1.52.03.50.40.4-1.0-1.21.2-1.8-1.7-1.7-1.7-1.9-1.7-1.4
Time in closed arm before self-admin1.11.43.4-1.8-1.8-1.8-1.6-1.0-0.9-0.9-0.7-0.7-0.50.1-1.0
Time in closed arm after self-admin1.41.52.6-0.0-0.0-1.2-1.40.8-1.6-1.5-1.5-1.5-1.5-1.4-1.1
Time in open arm before self-admin5.05.49.92.12.13.13.10.42.72.52.32.52.21.42.3
Time in open arm after self-admin0.20.20.5-0.7-0.7-0.7-0.6-0.4-0.6-0.4-0.3-0.2-0.20.10.4
Bone: periosteal estimation1.22.65.8-2.4-2.4-2.4-2.1-1.1-1.7-1.4-1.1-1.1-0.9-0.1-0.5
Bone: periosteal perimeter0.81.43.3-1.6-1.6-1.8-1.6-0.7-1.4-1.1-0.9-0.9-0.7-0.2-0.0
Bone: post-yield work0.50.72.2-1.5-1.5-0.8-0.5-1.3-0.00.10.30.30.50.80.5
Progressive ratio test 1 active lever presses0.20.20.50.50.50.60.70.10.70.50.50.50.50.30.1
Progressive ratio test 1 breakpoint0.10.10.20.40.40.40.40.10.50.30.30.30.20.2-0.1
Progressive ratio test 1 inactive lever presses3.24.68.61.31.32.72.8-0.32.92.62.42.42.31.61.4
Progressive ratio test 2 active lever presses0.20.30.80.00.00.40.5-0.40.90.60.60.70.70.60.1
Progressive ratio test 2 breakpoint0.20.30.80.10.10.40.5-0.30.90.60.60.70.70.60.1
Progressive ratio test 2 inactive lever presses0.40.71.80.50.50.80.9-0.21.31.00.91.01.00.80.1
Incentive Sensitization - Responses0.20.30.8-0.9-0.9-0.5-0.2-0.90.40.10.20.20.30.6-0.4
Incentive Sensitization - Breakpoint0.20.30.7-0.8-0.8-0.4-0.1-0.80.40.20.30.30.30.6-0.3
Sum of active levers in priming session hrs 5-60.70.61.8-1.0-1.0-1.3-1.1-0.2-0.9-0.9-0.8-0.4-0.50.1-0.0
Progressive ratio0.30.40.90.80.80.90.9-0.20.70.60.70.60.30.40.5
Food seeking constrained by brief footshock0.10.10.2-0.3-0.30.30.4-0.30.40.40.50.40.40.30.4
Seeking ratio, punishment vs. effort0.40.62.4-1.5-1.5-1.0-0.9-0.6-0.4-0.4-0.3-0.4-0.10.0-0.5
Retroperitoneal fat weight0.72.85.3-0.7-0.70.81.2-1.91.92.02.01.92.32.11.6
Reaction time number correct0.20.31.01.01.00.40.31.00.0-0.2-0.3-0.2-0.4-0.5-0.5
Reaction time mean minus median0.41.12.3-1.1-1.1-0.10.3-1.41.00.91.01.21.31.50.9
Reaction time mean minus median AUC0.10.30.8-0.7-0.7-0.30.0-0.80.60.40.40.60.60.90.2
Reaction time num false alarms1.62.34.92.02.02.22.20.91.71.41.11.30.90.40.8
Reaction time num false alarms AUC1.82.86.12.02.02.52.40.72.01.61.41.51.10.60.9
Reaction time trials correct on left0.20.31.01.01.00.40.31.00.0-0.2-0.3-0.2-0.4-0.5-0.5
Reaction time trials on left0.20.30.90.90.90.40.30.90.1-0.2-0.3-0.1-0.3-0.4-0.4
Reaction time mean0.91.43.7-1.9-1.9-0.9-0.4-1.90.40.50.70.81.01.50.7
Reaction time mean AUC0.91.43.4-1.7-1.7-0.6-0.1-1.80.80.70.91.01.21.60.9
Median of all reaction times0.81.23.5-1.9-1.9-1.0-0.6-1.80.20.30.50.50.71.20.6
Reaction time omissions0.40.71.6-0.8-0.8-0.30.1-1.20.60.60.70.91.01.20.6
Reaction time false alarm rate1.21.63.41.21.21.81.80.21.51.41.31.21.10.61.0
Reaction time premature initiation rate2.83.99.82.42.40.1-0.63.1-1.7-1.6-2.0-1.9-2.0-2.6-1.1
Reaction time premature initiations2.34.011.02.72.70.4-0.33.3-1.4-1.5-1.9-1.7-1.9-2.6-1.2
Std. dev. reaction times0.51.02.7-1.6-1.6-0.9-0.5-1.50.20.20.40.50.71.20.6
Reaction time trials completed0.20.30.90.90.90.40.30.90.1-0.2-0.3-0.1-0.3-0.4-0.4
Reaction time trials AUC0.10.30.90.90.90.50.40.90.2-0.1-0.2-0.0-0.2-0.4-0.4
Run reversals in cocaine runway, females0.40.40.9-0.7-0.70.20.5-0.90.90.60.70.60.50.7-0.4
Run reversals in cocaine runway, males1.31.32.30.80.8-0.4-0.81.5-1.2-1.2-1.3-1.3-1.3-1.5-0.9
Latency to leave start box in cocaine runway2.22.56.02.42.42.52.11.31.71.31.00.90.7-0.2-0.1
Latency to leave start box in cocaine runway, F2.42.86.62.02.02.62.40.82.11.61.41.31.10.30.3
Latency to leave start box in cocaine runway, M0.70.61.71.31.30.80.41.2-0.0-0.1-0.2-0.4-0.4-0.9-0.7
Std. dev. time between licks in bursts1.62.14.52.12.12.11.91.01.51.31.01.11.00.20.7
Total sessions with >9 infusions1.01.22.11.21.21.51.40.51.41.10.91.10.90.50.4
Short access day 1 total inactive lever presses0.30.41.61.31.30.40.21.1-0.2-0.1-0.3-0.1-0.1-0.50.4
Short access day 10 total inactive lever presses0.10.20.60.70.70.60.50.50.10.30.10.30.30.00.8
Short access day 1 total infusions0.60.81.50.50.51.01.0-0.01.21.10.91.11.10.80.8
Short access day 10 total infusions0.20.31.01.01.00.50.31.00.30.1-0.10.10.2-0.3-0.1
Short access total infusions0.50.61.31.21.21.00.90.80.90.60.40.60.60.10.2
Short access day 1 locomotion0.50.71.10.70.71.01.10.11.00.90.80.90.80.60.7
Short access day 10 total locomotion0.71.43.61.71.70.2-0.21.9-0.8-0.9-1.1-0.9-1.0-1.4-0.6
Short access total locomotion0.60.71.31.01.01.11.10.31.10.80.70.90.70.50.5
One hour access (0.3 mA shock)0.00.10.20.30.3-0.1-0.30.40.0-0.1-0.3-0.10.1-0.2-0.2
Compulsive drug intake0.40.50.80.20.20.90.9-0.40.90.90.90.70.70.60.6
One hour access (shock baseline)0.30.40.80.40.4-0.6-0.80.9-0.6-0.7-0.9-0.6-0.5-0.6-0.5
Social response proportion1.61.84.1-2.0-2.0-2.0-2.0-0.9-1.3-1.0-0.9-0.9-0.5-0.1-0.4
Social responses0.50.71.9-1.4-1.4-0.6-0.5-1.20.30.50.50.41.00.80.5
Social time0.30.51.0-0.7-0.7-0.10.1-0.80.80.60.60.80.91.00.4
Soleus weight0.20.50.8-0.3-0.3-0.8-0.90.3-0.8-0.9-0.8-0.8-0.8-0.6-0.6
Bone: stiffness1.93.19.4-3.1-3.1-1.5-0.8-2.90.20.50.80.81.21.91.0
Tibialis anterior weight0.20.81.80.90.91.31.30.11.11.00.90.90.70.40.6
Time to tail flick, vehicle, before self-admin0.40.51.5-0.6-0.6-0.10.4-0.90.60.40.50.90.51.20.6
Time to tail flick, vehicle, after self-admin0.10.10.4-0.6-0.6-0.20.0-0.60.00.00.20.20.10.40.4
Time to tail flick, test, before self-admin0.50.51.81.31.30.70.51.10.3-0.1-0.30.0-0.3-0.3-0.4
Time to tail flick, test, after self-admin0.70.71.20.30.31.01.0-0.51.01.11.10.91.00.60.7
Delta time to tail flick, vehicle, before/after SA0.10.00.10.30.30.40.20.20.10.20.1-0.10.1-0.3-0.0
Delta time to tail flick, test, before/after SA0.20.20.5-0.2-0.20.40.3-0.50.40.60.70.20.70.20.4
Tibia length2.36.221.2-4.6-4.6-2.9-2.0-3.9-0.6-0.30.30.20.62.00.5
Ambulatory time before self-admin0.40.61.7-1.3-1.3-1.1-0.9-1.0-0.4-0.3-0.2-0.10.00.40.1
Ambulatory time after self-admin0.40.51.81.31.30.50.31.20.1-0.1-0.3-0.1-0.1-0.5-0.1
Bone: tissue strength2.32.34.8-1.5-1.50.00.6-2.21.61.41.61.61.82.10.9
Total heroin consumption0.00.10.2-0.2-0.2-0.4-0.4-0.00.0-0.2-0.2-0.1-0.00.0-0.5
Bone: trabecular number2.03.27.3-2.7-2.7-2.6-2.3-1.6-1.8-1.4-1.1-1.2-1.0-0.0-0.7
Bone: trabecular spacing0.20.20.80.90.90.50.40.60.1-0.0-0.1-0.1-0.2-0.4-0.3
Bone: trabecular thickness1.41.73.4-1.3-1.3-1.8-1.8-0.3-1.6-1.4-1.2-1.3-1.1-0.6-0.7
Bone: trabecular tissue density0.71.01.7-0.1-0.10.81.0-0.81.11.21.21.21.21.11.3
Water consumed over 24 hours0.10.10.30.40.40.40.40.20.50.20.20.20.10.0-0.4
Number of responses in last shaping day1.41.62.7-0.0-0.01.21.4-1.01.61.51.61.51.41.31.0