Hspd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Hspd1	0.03	0.02	6.3e-04	0.02	0.02	0.01	0.02	1.7e-03	2.0e-03	1.4e-02	5.3e-03
2	pVTA	mRNA stability	Hspd1	0.08	0.06	2.7e-03	0.08	0.05	0.03	0.07	2.0e-04	3.9e-03	1.4e-02	5.9e-04
3	Liver	mRNA stability	Hspd1	0.21	0.1	0.0e+00	0.18	0.17	0.18	0.18	4.3e-20	8.9e-19	3.8e-19	9.2e-20
4	pVTA	gene expression	Hspd1	0.36	0.14	3.9e-11	0.09	0.23	0.21	0.22	1.5e-04	2.3e-10	1.2e-09	6.2e-10
5	Liver	gene expression	Hspd1	0.05	0.04	2.1e-05	0.01	0.03	0.03	0.03	3.2e-02	3.6e-04	4.6e-04	5.3e-04
6	NAcc	gene expression	Hspd1	0.13	0.08	2.8e-11	0.07	0.1	0.08	0.09	3.9e-08	4.3e-11	7.1e-10	6.9e-11
7	Brain	gene expression	Hspd1	0.2	0.09	0.0e+00	0.15	0.18	0.17	0.17	3.9e-14	2.3e-16	6.9e-16	8.9e-16
8	PL	gene expression	Hspd1	0.14	0.08	8.7e-11	0.07	0.09	0.08	0.08	6.2e-08	1.4e-09	2.7e-09	4.5e-09
9	BLA	gene expression	Hspd1	0.17	0.09	3.3e-07	0.04	0.12	0.13	0.13	1.8e-03	9.1e-07	1.5e-07	3.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	3.8	6.4	14.1	3.8	3.3	3.2	-2.2	-2.3	-1.9	-1.4	-1.7	2.1
Area under the delay curve	0.2	0.2	0.4	-0.1	-0.4	-0.4	-0.5	-0.5	-0.6	-0.6	-0.6	0.4
BMI with tail	1.6	5.1	14.2	-3.8	-3.7	-3.7	1.1	1.1	0.7	0.2	0.4	-0.9
BMI without tail	0.4	0.9	1.6	-0.5	0.2	0.1	1.3	1.2	1.2	1.2	1.2	-0.5
Body weight	0.3	1.4	4.6	1.6	2.1	2.0	0.1	0.2	0.4	0.7	0.7	-0.0
Weight adjusted by age	0.8	0.9	1.8	1.3	0.7	0.8	-1.0	-1.0	-0.9	-0.8	-0.9	1.0
Bone surface	3.5	6.2	13.9	3.7	3.3	3.3	-2.1	-2.1	-1.8	-1.3	-1.5	2.0
Bone volume	4.3	7.3	14.9	3.9	3.3	3.2	-2.5	-2.5	-2.2	-1.7	-2.0	2.3
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.1	-0.2	-0.2	-0.4	-0.2	-0.3	-0.3	-0.2	-0.0
Number of licking bursts	0.4	0.4	1.2	-0.7	-1.1	-1.1	-0.3	-0.3	-0.4	-0.6	-0.5	-0.0
Context. condit. distance diff. score	1.5	1.8	2.4	-1.5	-0.9	-0.9	1.5	1.5	1.5	1.3	1.3	-1.2
Locomotion velocity, session 1	0.2	0.2	0.6	-0.7	-0.8	-0.8	0.2	-0.0	-0.1	-0.2	-0.3	0.5
Locomotion distance, session 1	0.1	0.1	0.2	-0.3	-0.2	-0.1	0.5	0.4	0.3	0.3	0.3	0.2
Locomotion velocity, session 2	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.1	-0.4	-0.4	-0.5	-0.6	0.4
Locomotion distance, session 2	0.1	0.1	0.1	-0.4	-0.2	-0.2	0.4	0.3	0.3	0.3	0.3	-0.2
Locomotion velocity, session 3	0.9	1.1	1.9	-0.1	0.6	0.6	1.2	1.2	1.3	1.4	1.4	-0.9
Locomotion distance, session 3	0.1	0.2	0.3	-0.2	0.0	0.0	0.5	0.5	0.5	0.5	0.5	-0.1
Stereotopy head waving bouts, day 3	1.6	1.9	2.6	-1.3	-0.8	-0.7	1.6	1.6	1.5	1.4	1.4	-1.6
Stereotopy head waving duration, day 3	1.1	1.3	2.0	-0.4	0.1	0.2	1.4	1.4	1.4	1.4	1.4	-1.4
Locomotion velocity, session 7	0.3	0.4	0.8	-0.4	-0.6	-0.7	-0.3	-0.5	-0.5	-0.6	-0.7	0.9
Locomotion distance, session 7	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.2	-0.3	-0.3	-0.3	-0.4	0.4
Stereotopy head waving bouts, day 7	0.2	0.3	0.6	0.8	0.5	0.6	-0.4	-0.5	-0.4	-0.3	-0.4	0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.5	0.5	0.5	0.2	0.1	0.2	0.2	0.1	0.1
Locomotion velocity, session 8	0.9	1.0	1.7	-0.2	-0.8	-0.8	-0.9	-1.0	-1.1	-1.2	-1.3	1.3
Locomotion distance, session 8	0.8	1.2	1.9	-1.4	-0.9	-0.9	1.3	1.2	1.2	1.0	1.0	-0.7
Degree of sensitization distance	0.7	0.7	1.2	0.3	-0.1	-0.2	-1.1	-1.1	-1.1	-1.1	-1.1	0.7
Degree of sensitization stereotypy	0.7	0.7	1.1	0.9	0.4	0.4	-1.0	-1.0	-1.0	-0.9	-1.0	1.0
Conditioned locomotion	0.4	0.4	0.9	1.0	1.0	0.9	-0.7	-0.5	-0.5	-0.3	-0.3	0.3
Cocaine response after cond. corrected	4.2	4.7	6.9	1.7	0.7	0.7	-2.6	-2.6	-2.6	-2.5	-2.5	2.4
Cocaine response after cond. not corrected	4.9	5.4	7.6	2.2	1.2	1.2	-2.7	-2.8	-2.6	-2.5	-2.6	2.6
Cocaine response before conditioning	0.2	0.2	0.4	-0.1	0.1	0.1	0.6	0.5	0.6	0.6	0.5	-0.5
Saline control response	0.7	0.9	1.3	-0.7	-0.3	-0.2	1.1	1.1	1.1	1.1	1.1	-1.2
Bone: connectivity density	2.3	3.6	7.1	2.7	2.2	2.2	-1.8	-1.8	-1.6	-1.3	-1.5	1.8
Bone: cortical apparent density	3.4	4.4	11.8	-3.4	-3.4	-3.4	1.1	1.2	0.8	0.3	0.6	-1.1
Bone: cortical area	0.1	0.1	0.3	0.6	0.5	0.5	-0.3	-0.2	-0.2	-0.1	-0.1	0.0
Bone: cortical porosity	2.1	2.3	7.4	2.4	2.6	2.7	-0.2	-0.2	0.1	0.4	0.2	0.4
Bone: cortical porosity	2.8	3.0	9.5	2.8	3.0	3.1	-0.6	-0.5	-0.2	0.2	0.0	0.6
Bone: cortical thickness	0.6	1.0	2.5	-1.5	-1.6	-1.5	0.6	0.7	0.5	0.3	0.4	-0.7
Bone: cortical thickness	1.1	1.3	2.6	-1.0	-1.6	-1.6	-0.8	-0.8	-1.0	-1.2	-1.1	0.6
Bone: cortical tissue density	3.4	4.5	11.9	-3.5	-3.4	-3.4	1.2	1.2	0.8	0.3	0.6	-1.1
Condit. Reinf. active minus inactive responses	1.0	1.2	2.1	0.4	-0.2	-0.3	-1.4	-1.3	-1.4	-1.4	-1.3	1.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.2	0.3	-0.2	-0.3	-1.0	-1.0	-1.1	-1.1	-1.1	0.9
Condit. Reinf. active responses	1.6	2.0	3.5	1.0	0.3	0.2	-1.9	-1.7	-1.7	-1.7	-1.6	1.3
Condit. Reinf. inactive responses	0.4	0.5	1.0	0.5	0.2	0.2	-1.0	-0.8	-0.9	-0.8	-0.8	0.5
Incentive salience index mean	2.1	2.5	4.3	0.8	-0.2	-0.2	-2.1	-1.9	-2.0	-2.0	-1.9	1.5
Condit. Reinf. lever presses	0.8	1.0	1.8	0.8	0.2	0.2	-1.4	-1.2	-1.3	-1.2	-1.1	0.9
Condit. Reinf. active minus inactive responses	3.7	4.6	7.3	2.2	1.4	1.3	-2.7	-2.5	-2.5	-2.3	-2.3	1.8
Condit. Reinf. active-inactive response ratio	2.6	2.8	4.7	0.9	0.2	0.1	-2.2	-2.1	-2.1	-2.1	-2.0	1.5
Condit. Reinf. active responses	2.9	4.0	7.0	1.7	0.8	0.8	-2.6	-2.5	-2.5	-2.3	-2.3	1.5
Condit. Reinf. inactive responses	0.4	0.5	0.7	0.7	0.3	0.3	-0.8	-0.8	-0.8	-0.8	-0.8	0.6
Condit. Reinf. lever presses	2.0	2.7	4.8	-0.2	-1.1	-1.2	-1.9	-1.9	-2.0	-2.2	-2.1	1.1
Condit. Reinf. lever reinforcers received	3.4	4.8	8.3	1.7	0.7	0.6	-2.9	-2.7	-2.7	-2.6	-2.6	1.7
Conditioned reinforcement - actives	0.6	0.6	1.0	-0.2	0.5	0.4	0.9	0.9	1.0	1.0	0.9	-0.5
Conditioned reinforcement - inactives	0.0	0.0	0.2	0.2	0.4	0.3	0.2	0.1	0.2	0.2	0.1	0.1
Conditioned locomotion	0.3	0.3	1.0	-0.9	-0.9	-1.0	0.1	0.2	0.0	-0.1	0.1	-0.5
Patch foraging indifference point 0 sec	1.7	2.7	4.3	-0.4	-1.6	-1.6	-1.6	-1.7	-1.9	-2.1	-2.0	1.5
Patch foraging indifference point AUC	0.0	0.1	0.1	0.3	0.4	0.3	-0.1	-0.2	-0.1	-0.1	-0.2	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	2.6	-1.4	-1.6	-1.6	0.2	0.2	0.0	-0.2	-0.1	-0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.1	-0.2	-0.2	-0.5	-0.6	-0.6	-0.6	-0.6	0.4
Delay disc. indifference point, 2s delay	1.4	1.6	2.9	-1.0	-1.6	-1.7	-1.1	-1.0	-1.2	-1.4	-1.3	0.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.7	-0.4	-0.4	0.7	0.7	0.6	0.6	0.6	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	-0.8	-1.0	-1.0	-0.0	-0.0	-0.1	-0.3	-0.2	0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.6	0.7	0.6	-0.3	-0.4	-0.3	-0.2	-0.3	0.4
Indifference point function ln k	1.1	1.5	3.1	-0.9	-1.7	-1.7	-0.9	-0.9	-1.1	-1.3	-1.2	0.7
Indifference point function log k	1.1	1.5	3.1	-0.9	-1.7	-1.7	-0.9	-0.9	-1.1	-1.3	-1.2	0.7
Patch foraging total patch changes 0 sec	1.5	2.4	3.7	-0.6	-1.7	-1.7	-1.5	-1.5	-1.7	-1.9	-1.8	1.3
Patch foraging total patch changes 12 sec	0.9	1.2	1.9	-0.3	-1.0	-1.0	-1.2	-1.1	-1.2	-1.4	-1.3	0.8
Patch foraging total patch changes 18 sec	0.7	0.9	2.8	-1.2	-1.7	-1.7	-0.1	-0.3	-0.4	-0.7	-0.7	0.5
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.1	0.1	-0.0	-0.1	-0.2	-0.1	-0.1	-0.2	0.3
Patch foraging total patch changes 6 sec	0.6	0.9	1.5	-0.1	-0.8	-0.7	-1.0	-1.0	-1.1	-1.2	-1.2	0.8
Patch foraging time to switch 0 sec	0.9	1.3	2.3	0.2	0.9	0.9	1.4	1.3	1.4	1.5	1.4	-0.8
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.1	-0.1	-0.2	-0.6	-0.5	-0.5	-0.6	-0.5	0.0
Patch foraging water rate 12 sec	1.8	2.8	4.8	-0.3	-1.5	-1.5	-1.9	-1.8	-2.0	-2.2	-2.0	1.1
Patch foraging water rate 18 sec	0.6	0.8	1.8	0.5	-0.1	-0.1	-1.3	-1.1	-1.2	-1.2	-1.0	0.6
Patch foraging water rate 24 sec	0.1	0.2	0.2	0.2	0.4	0.5	0.4	0.4	0.4	0.5	0.4	-0.4
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	-0.1	-0.2	-0.3	-0.1	-0.2
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.4	1.5	1.2	1.3	-0.9	-0.8	-0.7	-0.5	-0.6	0.7
Distance traveled before self-admin	1.4	1.5	2.5	1.6	1.3	1.2	-1.2	-1.2	-1.1	-0.9	-0.9	1.3
Distance traveled after self-admin	0.3	0.4	1.2	-0.9	-1.0	-1.1	-0.2	-0.0	-0.2	-0.3	-0.2	0.0
Extensor digitorum longus weight	1.5	6.0	9.0	-3.0	-2.1	-2.2	2.7	2.7	2.5	2.2	2.3	-2.4
Bone: elastic displacement	0.6	0.6	1.2	-0.6	-1.1	-1.1	-0.7	-0.6	-0.8	-0.9	-0.8	0.3
Bone: elastic work	0.8	1.0	1.5	1.2	0.8	0.9	-1.1	-1.1	-1.0	-0.9	-0.9	0.9
Bone: endosteal estimation	2.3	5.1	12.2	3.5	3.2	3.1	-1.9	-1.8	-1.5	-1.1	-1.2	1.2
Bone: endosteal perimeter	2.1	4.4	10.9	3.3	3.1	3.0	-1.6	-1.6	-1.3	-0.8	-1.1	1.3
Epididymis fat weight	0.7	1.7	4.9	1.4	2.2	2.0	0.4	0.6	0.8	1.1	1.0	-0.8
Delta time in closed arm before/after self-admin	1.1	1.0	1.7	-0.6	0.1	0.1	1.3	1.2	1.2	1.2	1.1	-1.2
Delta time in open arm before/after self-admin	4.3	4.2	7.1	2.7	1.9	1.9	-2.2	-2.2	-2.0	-1.7	-1.8	1.9
Diff in mean of infusions in LGA sessions	0.8	0.8	1.2	0.8	0.1	0.3	-1.1	-1.1	-1.1	-1.0	-1.0	1.0
Delay discount exponential model param	0.2	0.3	0.4	0.1	0.3	0.4	0.5	0.6	0.6	0.6	0.6	-0.5
Extinction: sum of active levers before priming	0.3	0.3	0.9	0.9	0.8	0.8	-0.5	-0.3	-0.3	-0.2	-0.1	0.1
Active lever presses in extinction session 6	0.4	0.4	0.8	0.5	0.2	0.1	-0.9	-0.7	-0.8	-0.7	-0.6	0.6
Bone: final force	0.8	1.3	3.3	1.3	1.8	1.8	0.4	0.5	0.6	0.9	0.9	-0.9
Bone: final moment	0.7	1.2	2.5	1.0	1.6	1.6	0.5	0.7	0.8	1.0	1.0	-1.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.1	0.3	0.3	0.3	0.3	0.3	0.4	0.4	-0.2
Glucose	2.6	3.9	6.0	-1.3	-0.2	-0.3	2.3	2.4	2.4	2.3	2.5	-2.3
Heart weight	0.4	0.5	0.9	-0.1	-0.5	-0.6	-0.9	-0.8	-0.8	-0.9	-0.8	0.6
Delay discount hyperbolic model param	0.3	0.3	0.4	0.4	0.5	0.7	0.5	0.5	0.5	0.6	0.6	-0.4
Intermittent access intake day 1-15 change	0.6	0.6	0.9	-0.9	-0.5	-0.5	0.8	1.0	0.8	0.8	0.9	-0.7
Intermittent access intake escalation	0.4	0.4	0.7	-0.8	-0.4	-0.4	0.7	0.8	0.7	0.6	0.8	-0.6
Intermittent access intake escalation 2	0.1	0.1	0.1	0.1	0.3	0.3	0.2	0.2	0.2	0.3	0.3	-0.1
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.9	-1.7	-0.9	-0.9	1.4	1.4	1.3	1.1	1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	-0.4	-0.2	-0.2	0.3	0.3	0.3	0.3	0.3	-0.1
Intermitt. access escalation Index	1.5	1.4	2.1	0.1	1.0	1.0	1.1	1.2	1.3	1.4	1.5	-1.2
Intermittent access day 1 total infusions	0.2	0.2	0.7	0.6	0.8	0.7	-0.0	0.1	0.2	0.3	0.4	-0.3
Intermittent access day 15 total infusions	0.5	0.5	1.1	-0.2	0.4	0.4	0.7	0.9	0.8	0.9	1.0	-0.8
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.2	0.1	0.1	0.4	0.6	0.5	0.5	0.7	-0.6
Intermittent access total infusions	0.3	0.3	0.5	0.3	0.7	0.7	0.3	0.5	0.5	0.6	0.7	-0.5
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.0	0.1	0.1	0.0	0.1	-0.3
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.6	0.5	0.4	-0.4	-0.3	-0.3	-0.2	-0.1	0.2
Intermittent access total locomotion	0.0	0.1	0.1	0.0	0.3	0.1	0.1	0.2	0.2	0.3	0.4	-0.3
Intermittent access standard deviation	0.7	0.8	1.2	-1.0	-0.4	-0.4	0.9	1.1	0.9	0.9	1.1	-1.0
Left kidney weight	0.1	0.3	0.5	0.6	0.5	0.4	-0.7	-0.6	-0.6	-0.5	-0.5	0.3
Right kidney weight	0.2	0.5	0.8	0.7	0.5	0.4	-0.9	-0.8	-0.9	-0.8	-0.7	0.8
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.3	0.4	0.3	0.3	0.3	-0.3
Post-drug Anxiety	0.2	0.2	0.3	-0.1	-0.4	-0.2	-0.5	-0.5	-0.5	-0.6	-0.5	0.4
Baseline Anxiety	0.4	0.4	0.7	0.7	0.2	0.4	-0.8	-0.8	-0.8	-0.7	-0.8	0.7
Tail length	4.3	13.0	42.1	5.5	6.5	6.4	-0.2	-0.2	0.6	1.5	1.1	0.5
Length with tail	4.2	15.3	48.6	6.3	7.0	6.8	-1.0	-1.0	-0.2	0.8	0.4	1.0
Length without tail	0.4	1.0	2.6	1.6	1.4	1.4	-0.9	-0.7	-0.6	-0.4	-0.4	0.4
Times rat made contact with spout	0.4	0.4	0.7	-0.0	0.4	0.4	0.8	0.7	0.8	0.9	0.8	-0.6
Lifetime Intake	0.4	0.5	0.9	-0.1	0.5	0.4	0.6	0.8	0.8	0.8	0.9	-0.8
Liver weight, left	0.9	1.4	3.1	1.8	1.6	1.5	-1.0	-1.0	-0.8	-0.6	-0.8	1.1
Liver weight, right	0.6	0.9	2.3	1.5	1.5	1.4	-0.7	-0.7	-0.5	-0.3	-0.5	0.5
Locomotor activity	0.0	0.1	0.2	0.4	0.3	0.4	-0.2	-0.1	-0.1	-0.0	0.0	0.1
Locomotor testing distance	0.3	0.5	0.8	0.1	-0.4	-0.3	-0.8	-0.7	-0.9	-0.9	-0.8	0.7
Locomotor testing rearing	0.1	0.1	0.4	0.5	0.6	0.7	0.0	0.1	0.1	0.2	0.2	-0.0
Locomotion in novel chamber	0.7	0.8	2.4	-1.5	-1.5	-1.5	0.3	0.4	0.2	-0.0	0.1	-0.5
Locomotion in novel chamber post-restriction	0.6	0.7	1.4	-1.2	-1.1	-1.2	0.7	0.7	0.6	0.4	0.5	-0.8
Fecal boli incidents, locomotor time 1	3.0	3.3	4.7	2.2	1.4	1.4	-1.9	-2.1	-1.9	-1.7	-1.8	1.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.5	-0.4	-0.3	0.5	0.6	0.5	0.5	0.6	-0.7
Time >=10cm from walls, locomotor time 1	4.0	4.1	7.1	0.9	-0.3	-0.4	-2.3	-2.5	-2.5	-2.5	-2.7	2.0
Bouts of movement, locomotor time 1	0.6	0.6	0.9	0.6	0.1	0.1	-0.9	-0.9	-0.9	-0.9	-0.9	0.9
Total resting periods, locomotor time 1	0.6	0.6	1.1	-0.1	-0.7	-0.6	-0.8	-0.9	-0.9	-1.0	-1.0	0.8
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.5	-0.5	-0.4	0.4	0.5	0.4	0.3	0.4	-0.3
Distance moved, locomotor task time 1	0.5	0.6	0.9	0.6	0.2	0.2	-0.9	-0.9	-0.9	-0.9	-0.9	0.7
Vertical activity count, locomotor time 1	0.4	0.4	0.7	-0.4	-0.1	-0.1	0.8	0.7	0.8	0.8	0.7	-0.6
Time >=10cm from walls, locomotor time 2	4.2	4.5	7.0	1.3	0.1	0.0	-2.6	-2.6	-2.6	-2.6	-2.6	2.0
Bouts of movement, locomotor time 2	1.2	1.3	1.9	-0.6	-1.3	-1.3	-1.1	-1.0	-1.2	-1.4	-1.3	0.9
Total resting periods, locomotor time 2	1.3	1.4	2.1	-0.6	-1.4	-1.4	-1.1	-1.1	-1.3	-1.4	-1.3	0.8
Rest time, locomotor task time 2	0.4	0.5	0.8	-0.4	-0.1	-0.1	0.9	0.9	0.9	0.9	0.9	-0.7
Distance moved, locomotor task time 2	1.1	1.3	2.1	0.6	0.0	-0.0	-1.4	-1.4	-1.4	-1.4	-1.4	1.3
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.6	-0.7	-0.8	-0.2	-0.2	-0.3	-0.4	-0.3	0.2
Light reinforcement 1	1.5	2.7	6.0	-2.5	-2.1	-2.2	1.2	1.5	1.1	0.8	1.2	-1.3
Light reinforcement 2	0.6	0.8	1.4	-0.1	-0.7	-0.8	-1.1	-0.9	-1.1	-1.2	-0.9	0.5
Bone: marrow area	2.2	4.7	11.4	3.4	3.1	3.0	-1.8	-1.8	-1.5	-1.0	-1.2	1.2
Bone: maximum diameter	0.6	1.1	2.3	1.5	1.2	1.2	-0.9	-0.9	-0.8	-0.6	-0.7	1.0
Bone: maximum force	1.0	1.8	5.6	2.1	2.4	2.4	-0.2	-0.1	0.1	0.4	0.4	-0.4
Bone: maximum moment	0.8	1.4	4.3	1.7	2.1	2.1	-0.1	0.1	0.3	0.6	0.5	-0.6
Mean time between licks in bursts	1.1	1.6	2.5	-0.9	-0.1	-0.2	1.6	1.5	1.6	1.5	1.5	-1.3
Mean num. licks in bursts	0.4	0.5	0.8	0.5	0.9	0.9	0.6	0.6	0.7	0.8	0.7	-0.2
Cd content in liver	1.3	1.4	2.4	0.2	1.0	1.0	1.3	1.3	1.4	1.5	1.5	-1.0
Co content in liver	0.8	0.9	1.3	-1.0	-0.6	-0.6	1.2	1.1	1.1	1.0	1.0	-0.7
Cu content in liver	0.3	0.3	0.5	0.3	0.0	0.0	-0.7	-0.7	-0.7	-0.7	-0.7	0.5
Fe content in liver	0.7	0.9	2.0	1.4	1.3	1.3	-0.9	-0.8	-0.7	-0.5	-0.5	0.3
K content in liver	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.2	-0.2	-0.2	-0.3	-0.3	0.3
Mg content in liver	0.2	0.2	0.3	0.4	0.3	0.3	-0.5	-0.5	-0.4	-0.4	-0.4	0.6
Mn content in liver	0.9	1.0	2.4	-1.5	-1.5	-1.5	0.7	0.7	0.6	0.3	0.4	-0.7
Na content in liver	1.4	1.5	2.3	1.1	0.6	0.5	-1.5	-1.5	-1.4	-1.4	-1.4	1.1
Rb content in liver	2.1	2.6	3.8	1.3	0.5	0.5	-1.9	-1.9	-1.9	-1.8	-1.9	1.8
Se content in liver	0.1	0.1	0.1	-0.2	-0.4	-0.4	-0.3	-0.1	-0.2	-0.3	-0.1	-0.3
Sr content in liver	3.3	3.0	4.8	-0.7	0.6	0.6	2.0	2.1	2.1	2.1	2.2	-1.9
Zn content in liver	0.1	0.1	0.2	-0.1	0.2	0.2	0.4	0.4	0.5	0.5	0.4	-0.2
Bone: minimum diameter	0.3	0.6	1.5	1.2	1.1	1.1	-0.8	-0.6	-0.6	-0.4	-0.4	0.2
Time in familiar zone, hab. session 1	0.5	0.5	0.9	-0.0	0.4	0.4	0.9	0.8	0.9	0.9	0.8	-0.5
Time in novel zone, hab. session 1	0.5	0.5	0.8	-0.1	-0.4	-0.5	-0.9	-0.8	-0.9	-0.9	-0.8	0.5
Total zone transitions, hab. session 1	0.5	0.7	1.1	0.3	-0.3	-0.2	-0.8	-1.0	-1.0	-1.0	-1.1	1.0
Total locomotion distance, hab. session 1	1.1	1.5	2.5	0.7	-0.1	-0.1	-1.5	-1.5	-1.6	-1.6	-1.5	1.2
Locomotion velocity, hab. session 1	0.4	0.6	0.9	0.8	0.4	0.5	-1.0	-0.9	-0.9	-0.8	-0.8	0.7
Time in familiar zone, hab. session 2	0.5	0.5	1.7	-1.2	-1.2	-1.3	0.2	0.2	0.0	-0.1	-0.0	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.8	0.7	0.8	0.9	-0.0	0.1	0.1	0.3	0.3	-0.1
Total zone transitions, hab. session 2	0.4	0.5	0.8	0.3	0.7	0.8	0.8	0.7	0.8	0.9	0.9	-0.3
Total locomotion distance, hab. session 2	0.4	0.5	1.2	0.6	1.0	1.1	0.5	0.6	0.6	0.8	0.8	-0.3
Locomotion velocity, hab. session 2	0.6	0.8	1.9	0.8	1.3	1.4	0.6	0.7	0.8	1.0	0.9	-0.3
Novel to familiar place preference ratio	0.7	0.7	1.7	1.3	1.2	1.1	-0.9	-0.6	-0.6	-0.4	-0.3	0.1
Novelty place preference	0.7	0.7	1.8	1.4	1.2	1.2	-0.8	-0.6	-0.6	-0.4	-0.3	0.1
Time in novel zone, NPP test	0.6	0.6	1.4	1.2	1.0	1.0	-0.8	-0.6	-0.6	-0.4	-0.3	0.1
Total zone transitions, NPP test	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.3	0.3	0.2	0.2	0.2	-0.1
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.5	-0.7	-0.7	-0.3	-0.2	-0.3	-0.4	-0.2	-0.0
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.5	-0.6	-0.5	-0.0	0.1	-0.1	-0.1	0.0	-0.2
Intraocular pressure	1.4	2.0	5.3	-2.3	-2.2	-2.1	0.9	0.9	0.6	0.3	0.5	-1.1
Delta distance traveled before/after self-admin	1.2	1.3	2.9	-1.7	-1.5	-1.4	0.9	1.0	0.8	0.6	0.7	-1.1
Delta ambulatory time before/after self-admin	1.0	1.2	2.4	-1.6	-1.4	-1.3	0.8	1.0	0.7	0.5	0.8	-1.3
Parametrial fat weight	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	0.2	0.1	0.1	0.2	-0.2
Pavlov. Cond. lever latency	1.4	1.8	3.2	-0.8	0.1	0.1	1.8	1.6	1.7	1.7	1.6	-1.1
Pavlov. Cond. magazine entry latency	1.6	2.1	3.5	0.6	-0.3	-0.3	-1.9	-1.8	-1.9	-1.9	-1.8	1.2
Pavlov. Cond. change in total contacts	3.0	3.2	5.5	0.3	-0.9	-0.9	-2.2	-2.1	-2.2	-2.3	-2.2	1.6
Pavlov. Cond. index score	1.2	1.6	2.8	0.6	-0.2	-0.2	-1.7	-1.5	-1.6	-1.6	-1.5	1.0
Pavlov. Cond. latency score	1.6	2.1	3.7	0.9	0.0	0.0	-1.9	-1.8	-1.8	-1.8	-1.7	1.3
Pavlov. Cond. lever contacts	1.1	1.3	2.5	0.6	-0.2	-0.2	-1.6	-1.4	-1.5	-1.5	-1.4	0.9
Pavlov. Cond. magazine entry number	1.4	1.7	2.9	-0.8	0.0	0.0	1.7	1.6	1.7	1.7	1.6	-1.2
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.4	0.8	1.2	1.1	0.0	0.1	0.2	0.4	0.3	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.8	0.4	-0.4	-0.4	-1.7	-1.5	-1.6	-1.7	-1.5	1.1
Pavlov. Cond. response bias	0.8	1.0	1.7	0.5	-0.1	-0.1	-1.3	-1.2	-1.3	-1.3	-1.2	0.8
Pavlov. Cond. lever latency	1.3	1.7	2.9	0.2	1.0	1.1	1.4	1.5	1.6	1.7	1.7	-1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.2	-0.0	0.0	-0.0	-0.1	0.2
Pavlov. Cond. change in total contacts	2.3	3.2	5.4	0.2	-0.9	-0.9	-2.1	-2.1	-2.2	-2.3	-2.3	1.6
Pavlov. Cond. index score	1.0	1.3	2.3	-0.1	-0.8	-0.8	-1.2	-1.3	-1.4	-1.5	-1.5	0.9
Pavlov. Cond. latency score	0.8	1.0	1.8	-0.0	-0.6	-0.7	-1.1	-1.2	-1.2	-1.3	-1.3	0.8
Pavlov. Cond. lever contacts	2.1	2.8	5.0	0.1	-0.9	-1.0	-2.0	-2.0	-2.1	-2.2	-2.2	1.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.6	-0.3	-0.3	0.7	0.7	0.7	0.6	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.4	-0.4	-0.5	-0.2	-0.0	-0.2	-0.2	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.4	-0.1	-0.8	-0.8	-1.3	-1.4	-1.4	-1.5	-1.6	0.9
Pavlov. Cond. response bias	1.5	2.1	3.6	0.6	-0.2	-0.3	-1.7	-1.8	-1.8	-1.9	-1.9	1.3
Time in closed arm before self-admin	3.0	3.4	7.0	2.6	2.2	2.3	-1.6	-1.6	-1.4	-1.0	-1.2	1.9
Time in closed arm after self-admin	1.4	1.4	2.1	1.2	0.6	0.7	-1.3	-1.4	-1.3	-1.2	-1.3	1.5
Time in open arm before self-admin	5.8	6.3	10.1	-3.2	-2.1	-2.2	2.6	2.7	2.4	2.1	2.3	-2.8
Time in open arm after self-admin	0.1	0.2	0.4	0.6	0.6	0.5	-0.3	-0.3	-0.2	-0.1	-0.2	-0.3
Bone: periosteal estimation	1.4	2.8	7.1	2.7	2.4	2.4	-1.4	-1.3	-1.1	-0.8	-0.9	0.8
Bone: periosteal perimeter	1.0	1.7	4.1	2.0	1.8	1.8	-1.1	-1.1	-0.9	-0.6	-0.7	0.6
Bone: post-yield work	0.6	0.8	2.2	1.0	1.5	1.4	0.2	0.3	0.5	0.7	0.6	-0.7
Progressive ratio test 1 active lever presses	0.8	0.8	1.2	-0.2	0.6	0.4	1.0	1.0	1.1	1.1	1.1	-1.1
Progressive ratio test 1 breakpoint	0.5	0.5	0.9	-0.1	0.6	0.4	0.7	0.8	0.8	0.9	0.9	-0.9
Progressive ratio test 1 inactive lever presses	6.4	7.0	10.4	-2.2	-0.2	-0.2	3.2	3.2	3.2	3.1	3.2	-2.8
Progressive ratio test 2 active lever presses	1.0	1.0	1.7	0.2	1.0	0.9	1.1	1.1	1.2	1.3	1.3	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	1.2	-0.3	0.4	0.3	1.0	1.0	1.0	1.1	1.1	-0.7
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.4	-0.8	-0.1	-0.2	1.1	1.2	1.1	1.1	1.2	-0.9
Incentive Sensitization - Responses	0.6	0.6	1.4	0.7	1.2	1.1	0.5	0.5	0.6	0.8	0.7	0.0
Incentive Sensitization - Breakpoint	0.5	0.5	1.1	0.5	1.1	1.0	0.6	0.6	0.7	0.8	0.8	-0.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.2	1.1	0.8	0.8	-0.9	-0.8	-0.8	-0.6	-0.6	0.5
Progressive ratio	0.6	0.7	1.1	-0.9	-0.5	-0.9	1.0	0.9	0.9	0.8	0.8	-1.0
Food seeking constrained by brief footshock	0.1	0.2	0.3	0.1	0.4	0.6	0.5	0.4	0.5	0.5	0.5	-0.2
Seeking ratio, punishment vs. effort	0.5	0.6	2.2	1.1	1.1	1.5	-0.5	-0.4	-0.3	-0.2	-0.2	0.7
Retroperitoneal fat weight	0.2	0.6	1.3	-0.4	0.2	0.1	0.7	1.0	0.9	0.9	1.1	-1.2
Reaction time number correct	0.3	0.4	1.2	-0.7	-1.1	-1.0	-0.3	-0.2	-0.4	-0.5	-0.4	0.1
Reaction time mean minus median	0.8	1.0	1.5	0.4	1.1	1.1	0.8	1.0	1.0	1.2	1.2	-0.9
Reaction time mean minus median AUC	0.2	0.3	0.6	0.3	0.8	0.7	0.4	0.5	0.5	0.6	0.7	-0.3
Reaction time num false alarms	1.7	2.4	5.1	-2.3	-2.0	-1.9	1.4	1.3	1.2	0.9	0.9	-1.4
Reaction time num false alarms AUC	2.1	2.9	5.9	-2.4	-2.0	-1.9	1.7	1.6	1.5	1.1	1.2	-1.5
Reaction time trials correct on left	0.3	0.4	1.2	-0.7	-1.1	-1.0	-0.3	-0.2	-0.4	-0.5	-0.4	0.1
Reaction time trials on left	0.2	0.3	1.0	-0.7	-1.0	-0.9	-0.2	-0.2	-0.3	-0.5	-0.4	0.0
Reaction time mean	1.0	1.3	3.8	1.3	2.0	1.9	0.5	0.5	0.8	1.0	0.9	-0.4
Reaction time mean AUC	1.0	1.4	3.0	0.9	1.7	1.7	0.7	0.8	1.0	1.2	1.2	-0.7
Median of all reaction times	0.8	1.1	3.4	1.3	1.9	1.8	0.3	0.3	0.5	0.8	0.7	-0.2
Reaction time omissions	0.3	0.4	0.8	0.4	0.8	0.9	0.4	0.5	0.6	0.7	0.7	-0.6
Reaction time false alarm rate	1.2	1.7	2.7	-1.6	-1.2	-1.1	1.5	1.4	1.4	1.1	1.1	-1.2
Reaction time premature initiation rate	2.9	3.9	6.3	-1.2	-2.5	-2.5	-1.8	-1.7	-2.0	-2.3	-2.1	1.1
Reaction time premature initiations	3.0	4.3	8.3	-1.6	-2.9	-2.8	-1.7	-1.6	-2.0	-2.3	-2.1	1.0
Std. dev. reaction times	0.6	0.9	2.8	1.2	1.7	1.7	0.2	0.3	0.4	0.7	0.6	-0.4
Reaction time trials completed	0.2	0.3	1.0	-0.7	-1.0	-0.9	-0.2	-0.2	-0.3	-0.5	-0.4	0.0
Reaction time trials AUC	0.2	0.3	1.0	-0.8	-1.0	-0.9	-0.1	-0.1	-0.2	-0.4	-0.3	-0.0
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.0	0.6	0.5	0.8	0.7	0.8	0.8	0.7	-0.6
Run reversals in cocaine runway, males	1.1	1.1	1.8	-0.2	-0.9	-0.9	-1.2	-1.1	-1.2	-1.3	-1.2	0.9
Latency to leave start box in cocaine runway	2.7	2.9	7.6	-2.8	-2.4	-2.4	1.3	1.3	1.0	0.6	0.8	-1.3
Latency to leave start box in cocaine runway, F	2.4	2.7	6.3	-2.5	-2.0	-2.0	1.6	1.5	1.3	1.0	1.1	-1.1
Latency to leave start box in cocaine runway, M	0.4	0.4	1.2	-1.0	-1.0	-1.1	-0.0	-0.1	-0.2	-0.3	-0.3	-0.4
Std. dev. time between licks in bursts	2.2	2.6	5.6	-2.4	-2.1	-2.1	1.3	1.4	1.1	0.8	1.1	-1.6
Total sessions with >9 infusions	1.4	1.6	2.2	-1.3	-0.5	-0.5	1.4	1.5	1.4	1.3	1.4	-1.4
Short access day 1 total inactive lever presses	0.4	0.4	1.0	-0.6	-0.9	-1.0	-0.6	-0.4	-0.6	-0.6	-0.4	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.3	0.3	0.2	0.2	0.2	-0.2
Short access day 1 total infusions	0.4	0.5	0.7	-0.7	-0.2	-0.1	0.7	0.8	0.8	0.7	0.8	-0.8
Short access day 10 total infusions	0.0	0.1	0.1	0.3	0.3	0.3	-0.3	-0.1	-0.1	-0.1	0.1	-0.1
Short access total infusions	0.3	0.3	0.5	-0.6	-0.3	-0.2	0.5	0.7	0.6	0.5	0.7	-0.7
Short access day 1 locomotion	0.7	0.8	1.1	-0.7	0.0	-0.2	1.1	1.0	1.1	1.0	1.0	-1.0
Short access day 10 total locomotion	0.4	0.5	0.8	-0.2	-0.7	-0.7	-0.8	-0.7	-0.8	-0.9	-0.7	0.6
Short access total locomotion	0.3	0.3	0.4	0.0	0.5	0.4	0.5	0.6	0.6	0.7	0.6	-0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	0.1	0.0	-0.3	-0.0	-0.1	-0.1	0.1	-0.1
Compulsive drug intake	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.1	0.1	0.0	0.0	-0.0	-0.2
One hour access (shock baseline)	0.1	0.1	0.4	0.5	0.6	0.5	-0.3	-0.1	-0.1	0.0	0.2	-0.0
Social response proportion	1.7	1.9	4.7	2.2	1.9	2.0	-1.2	-1.0	-0.9	-0.6	-0.6	0.8
Social responses	0.6	0.8	1.8	0.8	1.2	1.3	0.3	0.6	0.6	0.8	0.9	-0.7
Social time	0.4	0.5	0.9	0.2	0.7	0.7	0.5	0.7	0.7	0.8	0.9	-0.6
Soleus weight	0.1	0.4	0.7	0.6	0.3	0.3	-0.8	-0.8	-0.7	-0.7	-0.7	0.6
Bone: stiffness	1.6	2.6	7.6	2.1	2.7	2.7	0.4	0.5	0.8	1.1	1.0	-0.7
Tibialis anterior weight	0.4	1.2	1.9	-1.4	-1.0	-1.0	1.3	1.2	1.1	0.9	1.0	-0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.2	0.1	0.1	0.6	0.5	0.6	0.5	0.4	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.5	0.6	0.6	0.1	-0.1	0.0	0.1	-0.0	0.3
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.8	-1.0	-1.0	-0.2	-0.2	-0.4	-0.5	-0.4	0.1
Time to tail flick, test, after self-admin	1.7	1.8	3.0	-1.2	-0.4	-0.4	1.6	1.6	1.5	1.4	1.5	-1.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.1	0.1	0.2	0.0
Delta time to tail flick, test, before/after SA	0.8	0.8	1.2	-0.6	-0.1	-0.1	1.1	1.1	1.1	1.0	1.1	-0.9
Tibia length	2.4	6.8	21.6	4.1	4.7	4.6	-0.3	-0.4	0.2	0.8	0.4	0.7
Ambulatory time before self-admin	0.7	0.8	1.7	1.0	0.8	0.7	-0.8	-0.8	-0.8	-0.6	-0.7	1.3
Ambulatory time after self-admin	0.9	0.9	2.9	-1.6	-1.7	-1.7	-0.1	0.1	-0.2	-0.4	-0.1	-0.3
Bone: tissue strength	2.3	2.2	3.7	0.5	1.4	1.4	1.6	1.5	1.7	1.9	1.8	-1.1
Total heroin consumption	0.0	0.0	0.1	0.1	0.2	0.2	-0.0	0.0	0.0	0.0	0.1	0.3
Bone: trabecular number	2.2	3.5	8.3	2.9	2.7	2.6	-1.4	-1.5	-1.1	-0.8	-1.0	1.5
Bone: trabecular spacing	0.2	0.2	0.8	-0.8	-0.8	-0.9	0.2	0.1	0.1	-0.0	-0.1	-0.1
Bone: trabecular thickness	1.6	1.9	3.1	1.8	1.3	1.3	-1.5	-1.5	-1.4	-1.2	-1.3	1.2
Bone: trabecular tissue density	0.8	1.1	1.7	-0.7	-0.2	-0.2	1.3	1.3	1.3	1.3	1.3	-1.1
Water consumed over 24 hours	0.3	0.3	1.1	-0.9	-1.0	-1.1	-0.0	-0.0	-0.1	-0.3	-0.2	-0.1
Number of responses in last shaping day	2.7	2.8	4.4	-1.2	-0.0	-0.1	2.1	2.0	2.0	2.0	1.9	-1.8