Hub : Genes

Hspb6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Hspb6 0.1 0.07 2.5e-04 0.09 0.02 0.08 0.04 1.2e-04 4.6e-02 2.3e-04 5.7e-03
2 Adipose gene expression Hspb6 0.12 0.07 5.6e-09 0.02 0.07 0.06 0.05 1.2e-03 3.7e-08 7.4e-07 1.7e-06
3 Brain gene expression Hspb6 0.16 0.09 3.5e-15 0.14 0.16 0.15 0.16 5.6e-13 5.3e-15 9.4e-14 1.6e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.61.02.00.9-0.41.4
Area under the delay curve0.50.61.40.7-1.20.1
BMI with tail0.00.10.2-0.5-0.2-0.5
BMI without tail0.30.91.50.9-1.20.6
Body weight3.012.916.23.7-3.04.0
Weight adjusted by age0.10.20.20.4-0.30.5
Bone surface1.52.72.81.6-1.71.7
Bone volume1.52.83.61.6-1.51.9
Breakpoint value in progressive ratio session1.11.32.01.1-1.40.7
Number of licking bursts2.13.44.7-2.10.9-2.2
Context. condit. distance diff. score0.20.20.5-0.2-0.7-0.1
Locomotion velocity, session 10.70.71.2-1.01.1-0.1
Locomotion distance, session 10.70.91.80.5-1.30.8
Locomotion velocity, session 20.70.81.1-0.80.7-1.1
Locomotion distance, session 21.01.42.3-1.50.0-1.4
Locomotion velocity, session 30.10.20.2-0.50.2-0.5
Locomotion distance, session 34.14.58.71.9-3.01.0
Stereotopy head waving bouts, day 31.31.53.8-0.71.9-0.5
Stereotopy head waving duration, day 32.22.75.8-1.22.4-0.9
Locomotion velocity, session 70.70.71.60.6-1.30.4
Locomotion distance, session 70.30.40.50.4-0.70.6
Stereotopy head waving bouts, day 71.61.82.8-1.50.7-1.7
Stereotopy head waving duration, day 72.12.63.1-1.81.3-1.7
Locomotion velocity, session 83.13.75.3-2.30.9-2.2
Locomotion distance, session 80.71.01.4-1.1-0.7-1.2
Degree of sensitization distance0.90.92.2-0.81.5-0.1
Degree of sensitization stereotypy1.31.42.5-1.30.1-1.6
Conditioned locomotion0.60.71.0-0.90.3-1.0
Cocaine response after cond. corrected0.40.51.5-0.11.20.1
Cocaine response after cond. not corrected0.60.72.00.11.40.3
Cocaine response before conditioning1.01.21.71.3-0.91.1
Saline control response0.20.20.5-0.40.7-0.1
Bone: connectivity density0.20.30.40.7-0.60.5
Bone: cortical apparent density1.11.52.6-1.61.0-1.0
Bone: cortical area1.52.23.21.6-1.01.8
Bone: cortical porosity1.21.33.3-0.8-0.2-1.8
Bone: cortical porosity1.71.94.2-1.2-0.1-2.1
Bone: cortical thickness0.50.91.71.0-0.31.3
Bone: cortical thickness0.60.71.1-0.91.0-0.5
Bone: cortical tissue density1.31.72.9-1.70.9-1.2
Condit. Reinf. active minus inactive responses0.20.20.3-0.50.4-0.5
Condit. Reinf. active-inactive response ratio0.40.51.2-0.21.1-0.3
Condit. Reinf. active responses1.92.33.3-1.80.9-1.7
Condit. Reinf. inactive responses2.02.43.9-2.00.3-1.8
Incentive salience index mean0.20.20.4-0.40.1-0.7
Condit. Reinf. lever presses0.10.20.3-0.0-0.5-0.5
Condit. Reinf. active minus inactive responses0.91.21.91.4-1.00.8
Condit. Reinf. active-inactive response ratio0.10.10.1-0.30.4-0.2
Condit. Reinf. active responses2.94.05.52.3-2.11.6
Condit. Reinf. inactive responses4.25.57.62.7-2.81.4
Condit. Reinf. lever presses6.18.511.23.3-2.62.8
Condit. Reinf. lever reinforcers received3.44.75.82.4-2.41.6
Conditioned reinforcement - actives0.71.11.4-1.21.1-0.8
Conditioned reinforcement - inactives0.71.02.50.3-1.6-0.7
Conditioned locomotion2.43.14.0-2.01.4-1.8
Patch foraging indifference point 0 sec0.10.10.20.5-0.4-0.2
Patch foraging indifference point AUC0.50.80.9-0.80.9-0.9
Delay disc. indifference point, 0s delay0.70.82.3-0.2-1.50.2
Delay disc. indifference point, 16s delay1.01.02.01.1-1.40.0
Delay disc. indifference point, 2s delay1.21.42.70.8-1.70.9
Delay disc. indifference point, 24s delay2.22.43.31.7-1.81.0
Delay disc. indifference point, 4s delay0.20.20.4-0.0-0.6-0.6
Delay disc. indifference point, 8s delay0.20.20.30.5-0.50.2
Indifference point function ln k0.20.40.50.5-0.60.7
Indifference point function log k0.20.40.50.5-0.60.7
Patch foraging total patch changes 0 sec0.10.20.40.6-0.5-0.1
Patch foraging total patch changes 12 sec0.10.20.30.30.5-0.5
Patch foraging total patch changes 18 sec0.10.10.3-0.1-0.2-0.5
Patch foraging total patch changes 24 sec0.50.91.60.8-1.30.7
Patch foraging total patch changes 6 sec0.10.10.20.50.2-0.4
Patch foraging time to switch 0 sec0.51.12.0-0.71.4-0.9
Patch foraging water rate 0 sec0.30.61.1-0.80.3-1.1
Patch foraging water rate 12 sec0.51.02.10.8-1.40.6
Patch foraging water rate 18 sec0.10.20.2-0.50.2-0.4
Patch foraging water rate 24 sec0.71.02.6-0.1-1.6-0.6
Patch foraging water rate 6 sec1.42.04.51.1-2.10.7
Seeking ratio, delayed vs. immediate footshock1.72.14.41.1-2.10.8
Distance traveled before self-admin0.00.00.1-0.0-0.30.0
Distance traveled after self-admin1.72.12.61.6-1.31.5
Extensor digitorum longus weight0.31.12.5-0.81.60.5
Bone: elastic displacement0.10.10.2-0.00.50.2
Bone: elastic work1.41.92.61.4-1.01.6
Bone: endosteal estimation1.32.93.61.9-1.51.7
Bone: endosteal perimeter1.12.42.71.6-1.61.3
Epididymis fat weight0.00.10.30.0-0.10.6
Delta time in closed arm before/after self-admin1.31.21.31.2-0.91.2
Delta time in open arm before/after self-admin0.40.40.5-0.40.7-0.7
Diff in mean of infusions in LGA sessions0.50.61.2-0.80.2-1.1
Delay discount exponential model param0.70.71.4-0.91.2-0.2
Extinction: sum of active levers before priming3.33.66.41.9-0.92.5
Active lever presses in extinction session 61.51.52.81.20.61.7
Bone: final force1.82.83.51.9-1.41.8
Bone: final moment2.43.84.62.1-1.52.1
Food consumed during 24 hour testing period0.91.32.71.0-1.60.3
Glucose0.50.71.6-0.71.3-0.1
Heart weight0.20.30.60.4-0.8-0.2
Delay discount hyperbolic model param0.50.51.2-0.71.1-0.1
Intermittent access intake day 1-15 change1.32.64.11.3-1.42.0
Intermittent access intake escalation1.02.03.81.1-1.02.0
Intermittent access intake escalation 21.01.12.01.0-0.51.4
Intermitt. access day 1 inactive lever presses1.55.58.02.6-2.81.3
Intermitt. access day 15 inactive lever presses1.02.14.41.3-2.10.1
Intermitt. access escalation Index0.20.30.3-0.5-0.5-0.6
Intermittent access day 1 total infusions1.62.54.1-1.90.2-2.0
Intermittent access day 15 total infusions0.20.30.5-0.6-0.7-0.2
Intermittent access terminal intake (last 3 days)0.50.70.9-0.9-0.6-0.9
Intermittent access total infusions0.70.91.4-1.2-0.4-1.0
Intermittent access day 1 locomotion1.51.93.5-1.3-0.7-1.9
Intermittent access day 15 total locomotion0.30.51.2-0.4-1.1-0.5
Intermittent access total locomotion1.21.52.4-1.5-0.0-1.5
Intermittent access standard deviation2.14.35.72.0-2.41.8
Left kidney weight2.19.714.23.1-2.23.8
Right kidney weight2.511.317.73.4-2.14.2
Cocaine induced anxiety0.00.00.00.10.20.2
Post-drug Anxiety0.00.10.1-0.10.1-0.4
Baseline Anxiety0.30.30.60.2-0.8-0.6
Tail length4.517.620.64.4-3.64.5
Length with tail6.327.331.55.6-4.45.5
Length without tail3.09.712.43.2-2.53.5
Times rat made contact with spout0.80.91.8-1.01.30.1
Lifetime Intake0.81.01.8-1.30.1-1.0
Liver weight, left0.50.81.0-0.91.0-0.8
Liver weight, right0.40.71.2-0.71.1-0.6
Locomotor activity0.91.43.7-0.61.9-0.6
Locomotor testing distance0.81.53.0-1.01.7-0.7
Locomotor testing rearing1.32.73.5-1.91.7-1.3
Locomotion in novel chamber0.40.50.9-0.60.9-0.5
Locomotion in novel chamber post-restriction0.10.10.2-0.20.3-0.5
Fecal boli incidents, locomotor time 12.84.04.1-1.92.0-2.0
Change in fecal boli incidents, locomotor task0.40.41.00.11.00.4
Time >=10cm from walls, locomotor time 10.10.10.1-0.30.2-0.2
Bouts of movement, locomotor time 11.01.13.00.5-1.70.3
Total resting periods, locomotor time 10.60.72.00.4-1.40.2
Rest time, locomotor task time 11.82.32.6-1.51.4-1.6
Distance moved, locomotor task time 10.10.20.20.4-0.50.4
Vertical activity count, locomotor time 11.22.93.61.9-1.81.3
Time >=10cm from walls, locomotor time 21.11.62.6-1.21.0-1.6
Bouts of movement, locomotor time 20.00.00.0-0.2-0.2-0.1
Total resting periods, locomotor time 20.00.10.1-0.30.1-0.3
Rest time, locomotor task time 20.60.71.0-0.70.8-1.0
Distance moved, locomotor task time 20.00.10.20.1-0.40.0
Vertical activity count, locomotor time 21.01.42.11.2-1.40.8
Light reinforcement 10.10.20.4-0.4-0.2-0.6
Light reinforcement 21.82.83.5-1.91.4-1.7
Bone: marrow area1.32.93.81.9-1.41.7
Bone: maximum diameter1.32.43.01.7-1.21.6
Bone: maximum force2.85.05.82.4-1.92.3
Bone: maximum moment3.45.96.72.6-2.12.6
Mean time between licks in bursts0.10.30.70.3-0.8-0.3
Mean num. licks in bursts1.11.73.81.2-0.01.9
Cd content in liver0.20.20.4-0.60.4-0.1
Co content in liver0.50.61.1-0.51.1-0.5
Cu content in liver1.11.31.61.2-1.01.3
Fe content in liver0.40.50.6-0.60.7-0.7
K content in liver0.10.10.20.4-0.1-0.2
Mg content in liver0.80.81.6-0.31.3-0.7
Mn content in liver1.21.33.0-0.61.7-0.7
Na content in liver0.70.71.11.1-0.80.6
Rb content in liver0.10.10.2-0.3-0.0-0.5
Se content in liver5.66.79.1-2.53.0-2.2
Sr content in liver0.40.40.8-0.10.9-0.5
Zn content in liver2.02.23.5-1.21.9-1.3
Bone: minimum diameter3.15.77.32.5-2.71.9
Time in familiar zone, hab. session 10.90.82.00.60.41.4
Time in novel zone, hab. session 11.71.74.0-1.00.1-2.0
Total zone transitions, hab. session 10.10.20.3-0.4-0.6-0.2
Total locomotion distance, hab. session 10.71.01.41.2-1.20.4
Locomotion velocity, hab. session 10.30.50.80.9-0.70.3
Time in familiar zone, hab. session 21.31.43.01.7-0.21.1
Time in novel zone, hab. session 20.90.91.8-1.30.5-0.8
Total zone transitions, hab. session 22.73.54.7-2.11.1-2.2
Total locomotion distance, hab. session 20.40.51.2-0.4-0.3-1.1
Locomotion velocity, hab. session 20.40.51.2-0.5-0.1-1.1
Novel to familiar place preference ratio0.20.20.40.6-0.60.1
Novelty place preference0.20.20.30.5-0.60.0
Time in novel zone, NPP test0.10.10.20.2-0.4-0.1
Total zone transitions, NPP test0.10.10.3-0.6-0.00.0
Total locomotion distance, NPP test1.82.42.81.7-1.41.6
Locomotion velocity, NPP test1.82.63.31.8-1.31.6
Intraocular pressure0.10.10.1-0.3-0.2-0.3
Delta distance traveled before/after self-admin2.42.53.21.8-1.31.6
Delta ambulatory time before/after self-admin2.12.63.21.8-1.51.6
Parametrial fat weight0.61.54.4-0.22.10.4
Pavlov. Cond. lever latency0.20.30.70.20.10.9
Pavlov. Cond. magazine entry latency0.91.21.8-1.00.9-1.4
Pavlov. Cond. change in total contacts0.80.81.9-0.6-0.4-1.4
Pavlov. Cond. index score0.70.91.8-0.80.5-1.3
Pavlov. Cond. latency score0.40.51.3-0.50.1-1.2
Pavlov. Cond. lever contacts0.20.20.40.2-0.4-0.6
Pavlov. Cond. magazine entry number0.70.81.60.9-0.51.3
Pavlov. Cond. intertrial magazine entries0.70.81.4-1.20.8-0.6
Pavlov. Cond. lever-magazine prob. diff.1.01.22.4-1.00.6-1.6
Pavlov. Cond. response bias0.50.60.9-0.60.8-1.0
Pavlov. Cond. lever latency4.86.57.6-2.82.6-2.2
Pavlov. Cond. magazine entry latency2.93.55.12.3-1.81.5
Pavlov. Cond. change in total contacts6.710.712.03.5-3.42.9
Pavlov. Cond. index score5.27.08.52.9-2.62.3
Pavlov. Cond. latency score4.56.07.52.7-2.52.0
Pavlov. Cond. lever contacts5.17.07.92.8-2.82.4
Pavlov. Cond. magazine entry number3.84.75.5-2.32.0-2.2
Pavlov. Cond. intertrial magazine entries0.71.11.3-1.11.0-1.0
Pavlov. Cond. lever-magazine prob. diff.4.86.47.92.8-2.42.3
Pavlov. Cond. response bias6.38.69.53.1-3.12.6
Time in closed arm before self-admin1.31.62.4-1.60.5-1.5
Time in closed arm after self-admin0.20.30.7-0.1-0.9-0.2
Time in open arm before self-admin3.43.85.32.3-1.12.2
Time in open arm after self-admin0.91.01.81.3-0.21.0
Bone: periosteal estimation2.04.25.12.3-1.62.2
Bone: periosteal perimeter1.01.72.31.5-0.91.4
Bone: post-yield work2.43.55.41.9-2.31.3
Progressive ratio test 1 active lever presses0.20.30.7-0.3-0.8-0.3
Progressive ratio test 1 breakpoint0.30.40.9-0.2-1.0-0.3
Progressive ratio test 1 inactive lever presses1.11.74.50.2-2.1-0.7
Progressive ratio test 2 active lever presses0.30.41.1-1.00.2-0.3
Progressive ratio test 2 breakpoint0.50.51.4-1.20.3-0.4
Progressive ratio test 2 inactive lever presses0.71.23.50.1-1.9-0.2
Incentive Sensitization - Responses0.50.71.6-1.30.5-0.4
Incentive Sensitization - Breakpoint0.50.61.5-1.20.5-0.4
Sum of active levers in priming session hrs 5-60.10.10.1-0.30.30.0
Progressive ratio0.10.20.50.1-0.1-0.7
Food seeking constrained by brief footshock1.82.23.11.8-1.41.2
Seeking ratio, punishment vs. effort0.40.60.80.6-0.90.7
Retroperitoneal fat weight1.14.913.0-1.23.6-0.3
Reaction time number correct0.00.00.1-0.10.10.2
Reaction time mean minus median0.30.71.11.0-0.50.8
Reaction time mean minus median AUC0.61.52.11.5-0.61.4
Reaction time num false alarms0.70.91.2-1.10.8-1.0
Reaction time num false alarms AUC0.91.41.6-1.31.0-1.2
Reaction time trials correct on left0.00.00.1-0.10.10.2
Reaction time trials on left0.00.00.1-0.10.10.3
Reaction time mean0.20.30.50.5-0.50.7
Reaction time mean AUC0.10.20.30.4-0.30.5
Median of all reaction times0.00.00.1-0.0-0.30.2
Reaction time omissions0.10.10.30.20.60.2
Reaction time false alarm rate0.60.81.1-1.00.7-1.1
Reaction time premature initiation rate0.30.40.50.2-0.7-0.7
Reaction time premature initiations0.10.20.40.1-0.6-0.6
Std. dev. reaction times0.61.21.31.1-1.01.1
Reaction time trials completed0.00.00.1-0.10.10.3
Reaction time trials AUC0.10.10.2-0.20.40.3
Run reversals in cocaine runway, females1.01.01.60.7-1.31.0
Run reversals in cocaine runway, males1.11.13.30.21.80.2
Latency to leave start box in cocaine runway0.50.61.30.4-1.10.6
Latency to leave start box in cocaine runway, F0.30.31.00.2-1.00.1
Latency to leave start box in cocaine runway, M0.10.10.1-0.0-0.40.4
Std. dev. time between licks in bursts0.91.22.00.8-1.4-1.0
Total sessions with >9 infusions1.11.41.9-1.41.2-0.9
Short access day 1 total inactive lever presses1.62.16.20.4-2.5-0.1
Short access day 10 total inactive lever presses1.84.38.61.8-2.91.0
Short access day 1 total infusions0.10.10.1-0.2-0.3-0.3
Short access day 10 total infusions0.40.51.0-1.00.5-0.6
Short access total infusions0.81.01.6-1.30.8-0.9
Short access day 1 locomotion0.81.01.5-1.20.7-0.9
Short access day 10 total locomotion0.40.81.80.6-1.3-0.5
Short access total locomotion1.31.62.6-1.30.6-1.6
One hour access (0.3 mA shock)0.91.13.10.3-1.70.1
Compulsive drug intake0.40.40.90.1-1.0-0.6
One hour access (shock baseline)0.10.10.3-0.4-0.5-0.1
Social response proportion1.51.72.21.5-1.31.1
Social responses0.40.51.11.0-0.60.2
Social time2.63.54.91.8-2.21.6
Soleus weight0.10.20.4-0.30.6-0.0
Bone: stiffness1.52.42.61.6-1.51.6
Tibialis anterior weight0.31.02.1-0.51.40.9
Time to tail flick, vehicle, before self-admin0.20.20.4-0.40.2-0.6
Time to tail flick, vehicle, after self-admin0.10.10.30.5-0.2-0.1
Time to tail flick, test, before self-admin0.50.61.5-0.5-1.20.0
Time to tail flick, test, after self-admin0.10.10.2-0.40.2-0.4
Delta time to tail flick, vehicle, before/after SA0.50.50.90.9-0.60.4
Delta time to tail flick, test, before/after SA1.21.23.1-0.41.7-0.7
Tibia length2.56.98.82.5-2.43.0
Ambulatory time before self-admin0.10.10.20.2-0.5-0.0
Ambulatory time after self-admin3.74.45.02.2-2.11.9
Bone: tissue strength3.63.65.41.9-2.31.4
Total heroin consumption0.50.61.40.5-1.20.3
Bone: trabecular number1.32.12.41.4-1.31.6
Bone: trabecular spacing0.20.30.70.80.20.3
Bone: trabecular thickness0.10.10.2-0.5-0.10.4
Bone: trabecular tissue density2.73.98.2-1.82.9-0.6
Water consumed over 24 hours0.40.60.90.7-0.41.0
Number of responses in last shaping day0.10.10.30.1-0.50.1