Hub : Genes

Hsd17b6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Hsd17b6	0.34	0.13	0.0e+00	0.32	0.31	0.31	0.32	7.0e-36	8.2e-35	2.4e-35	3.4e-36
2	Liver	isoform ratio	XM_039078532.1	0.12	0.08	1.4e-09	0.07	0.07	0.08	0.08	2.2e-08	9.5e-09	3.0e-09	2.0e-09
3	Liver	intron excision ratio	chr7_425908_429139	0.06	0.04	1.6e-04	0.02	0.03	0.04	0.03	6.1e-03	2.1e-04	4.1e-05	1.2e-04
4	Liver	intron excision ratio	chr7_423005_425745	0.08	0.06	3.1e-06	0.06	0.04	0.05	0.06	1.0e-07	8.7e-06	1.2e-06	5.1e-07
5	Liver	gene expression	Hsd17b6	0.8	0.04	0.0e+00	0.6	0.56	0.61	0.63	1.4e-82	2.4e-74	2.3e-85	2.6e-89
6	Liver	alternative TSS	NM_173305.2	0.3	0.15	0.0e+00	0.19	0.18	0.19	0.19	1.6e-20	2.4e-19	5.0e-21	3.7e-21
7	Liver	intron excision ratio	chr7_432171_441762	0.53	0.13	0.0e+00	0.41	0.42	0.43	0.43	2.0e-48	4.5e-50	2.6e-51	1.1e-51
8	Liver	alternative TSS	XM_039078532.1	0.54	0.14	0.0e+00	0.38	0.38	0.4	0.41	5.7e-45	8.5e-45	7.4e-47	2.4e-48
9	Liver	alternative TSS	XM_017594688.2	0.39	0.15	0.0e+00	0.24	0.25	0.25	0.26	1.2e-26	1.3e-27	7.4e-28	6.3e-29
10	Liver	isoform ratio	XM_017594688.2	0.59	0.14	0.0e+00	0.32	0.34	0.35	0.36	8.9e-36	1.9e-38	9.9e-41	3.9e-41
11	Liver	alternative TSS	XM_017594688.2	0.29	0.14	0.0e+00	0.21	0.19	0.21	0.21	8.3e-23	7.1e-21	4.2e-23	1.1e-22
12	Liver	intron excision ratio	chr7_432171_441123	0.54	0.15	0.0e+00	0.34	0.37	0.38	0.38	4.5e-39	2.0e-43	6.0e-45	5.5e-45
13	Liver	alternative TSS	NM_173305.2	0.31	0.15	0.0e+00	0.2	0.19	0.2	0.2	2.4e-21	2.7e-20	4.5e-22	5.4e-22
14	Liver	isoform ratio	NM_173305.2	0.13	0.08	3.2e-09	0.08	0.08	0.08	0.08	8.9e-09	7.5e-09	3.7e-09	3.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14
Bone: apparent density	0.8	1.3	2.1	-0.6	-0.8	1.4	0.8	1.1	1.1	-1.1	-1.3	1.1	1.5	0.9	1.3	-1.2	-1.3
Area under the delay curve	0.1	0.1	0.1	-0.1	-0.2	-0.0	0.3	0.2	0.2	-0.3	-0.3	0.3	0.4	0.1	0.3	-0.2	-0.4
BMI with tail	7.7	24.8	27.9	-5.2	-5.2	-4.6	5.3	5.0	5.0	-5.1	-4.9	5.0	4.8	5.1	4.8	-4.9	-4.8
BMI without tail	0.9	1.9	2.8	-1.7	-1.6	-1.2	1.3	1.4	1.5	-1.3	-1.3	1.3	1.1	1.6	1.2	-1.4	-1.1
Body weight	1.0	4.2	5.1	-2.3	-2.2	-1.6	2.0	2.1	2.1	-2.1	-2.0	2.1	1.9	2.1	2.0	-2.0	-2.0
Weight adjusted by age	0.1	0.1	0.3	0.1	0.1	-0.6	-0.1	-0.2	-0.2	0.2	0.2	-0.3	-0.3	-0.1	-0.3	0.2	0.4
Bone surface	1.1	2.0	7.5	-0.5	-0.8	2.7	0.6	1.2	1.3	-1.2	-1.5	1.3	1.7	0.9	1.6	-1.3	-1.7
Bone volume	1.5	2.5	6.5	-0.7	-1.1	2.5	0.8	1.5	1.5	-1.4	-1.8	1.6	1.9	1.2	1.8	-1.6	-1.8
Breakpoint value in progressive ratio session	2.3	2.5	3.0	1.7	1.7	0.7	-1.5	-1.7	-1.7	1.6	1.7	-1.6	-1.6	-1.6	-1.5	1.6	1.4
Number of licking bursts	2.0	2.4	4.9	-1.8	-1.7	-2.2	1.7	1.5	1.5	-1.5	-1.3	1.5	1.2	1.6	1.3	-1.4	-1.3
Context. condit. distance diff. score	0.1	0.1	0.3	-0.5	-0.5	-0.4	0.3	0.4	0.5	-0.3	-0.3	0.3	0.3	0.4	0.3	-0.4	-0.1
Locomotion velocity, session 1	0.4	0.5	1.0	-0.4	-0.5	1.0	0.3	0.7	0.7	-0.6	-0.7	0.6	0.8	0.6	0.7	-0.8	-0.8
Locomotion distance, session 1	0.2	0.3	2.2	0.1	-0.1	1.5	0.0	0.2	0.3	-0.3	-0.4	0.4	0.5	0.2	0.5	-0.4	-0.7
Locomotion velocity, session 2	0.5	0.5	5.5	0.7	0.6	2.3	-0.7	-0.3	-0.3	0.4	0.2	-0.2	-0.1	-0.4	-0.1	0.1	-0.0
Locomotion distance, session 2	1.3	1.7	7.6	1.6	1.4	2.8	-1.4	-1.2	-1.2	1.1	1.0	-0.9	-0.9	-1.3	-0.7	1.0	0.4
Locomotion velocity, session 3	5.2	6.1	6.7	2.6	2.5	2.2	-2.6	-2.5	-2.5	2.6	2.5	-2.5	-2.4	-2.5	-2.4	2.4	2.3
Locomotion distance, session 3	0.3	0.3	0.3	0.4	0.4	0.6	-0.6	-0.5	-0.4	0.6	0.5	-0.5	-0.6	-0.5	-0.6	0.6	0.5
Stereotopy head waving bouts, day 3	4.2	4.9	6.6	2.6	2.5	2.2	-2.3	-2.3	-2.3	2.2	2.1	-2.2	-2.0	-2.2	-2.0	2.0	1.9
Stereotopy head waving duration, day 3	2.4	2.9	4.0	2.0	1.9	1.7	-1.7	-1.8	-1.8	1.7	1.6	-1.6	-1.5	-1.8	-1.5	1.6	1.4
Locomotion velocity, session 7	0.0	0.0	0.4	0.1	0.0	0.6	-0.1	0.0	0.0	-0.1	-0.1	0.1	0.1	0.0	0.2	-0.1	-0.3
Locomotion distance, session 7	0.0	0.1	0.8	-0.1	-0.1	-0.9	0.2	-0.0	-0.0	-0.1	0.1	0.1	-0.1	-0.0	0.0	0.1	-0.1
Stereotopy head waving bouts, day 7	0.6	0.7	4.8	0.8	0.7	2.2	-1.0	-0.5	-0.5	0.6	0.4	-0.6	-0.4	-0.5	-0.4	0.3	0.5
Stereotopy head waving duration, day 7	0.5	0.6	5.1	0.7	0.6	2.3	-0.9	-0.3	-0.3	0.5	0.2	-0.4	-0.2	-0.4	-0.3	0.2	0.3
Locomotion velocity, session 8	0.6	0.7	5.7	1.0	0.7	2.4	-0.9	-0.6	-0.5	0.6	0.5	-0.4	-0.3	-0.7	-0.3	0.4	0.1
Locomotion distance, session 8	0.2	0.3	0.9	0.7	0.6	0.9	-0.6	-0.5	-0.5	0.5	0.5	-0.4	-0.4	-0.6	-0.4	0.5	0.3
Degree of sensitization distance	0.8	0.8	1.0	-0.9	-0.8	-1.0	1.0	0.9	0.8	-1.0	-0.9	1.0	0.9	0.9	1.0	-0.9	-1.0
Degree of sensitization stereotypy	0.3	0.3	1.3	-0.4	-0.4	1.1	0.0	0.5	0.6	-0.4	-0.6	0.4	0.5	0.5	0.5	-0.6	-0.4
Conditioned locomotion	0.3	0.4	3.7	-0.7	-0.5	-1.9	0.7	0.4	0.3	-0.4	-0.2	0.3	0.2	0.4	0.2	-0.2	-0.0
Cocaine response after cond. corrected	1.1	1.2	3.4	-1.4	-1.2	-1.8	1.0	1.1	1.1	-1.0	-0.9	0.9	0.7	1.2	0.7	-1.0	-0.5
Cocaine response after cond. not corrected	1.1	1.2	3.4	-1.4	-1.2	-1.8	1.0	1.1	1.1	-1.0	-0.9	0.8	0.7	1.2	0.7	-1.0	-0.5
Cocaine response before conditioning	0.3	0.4	1.0	0.7	0.7	1.0	-0.7	-0.6	-0.6	0.6	0.5	-0.5	-0.5	-0.6	-0.5	0.6	0.4
Saline control response	0.1	0.2	0.3	-0.6	-0.5	-0.5	0.4	0.4	0.5	-0.4	-0.3	0.3	0.3	0.5	0.3	-0.4	-0.2
Bone: connectivity density	0.4	0.6	1.2	-0.4	-0.5	1.1	0.6	0.8	0.8	-0.7	-0.9	0.7	1.0	0.6	0.9	-0.8	-0.8
Bone: cortical apparent density	1.6	2.1	3.1	-1.5	-1.5	-1.7	1.8	1.5	1.4	-1.5	-1.4	1.3	1.5	1.4	1.2	-1.3	-1.0
Bone: cortical area	2.3	3.4	5.0	-1.6	-1.7	-0.1	1.8	1.9	1.9	-2.0	-2.0	2.1	2.1	1.7	2.1	-1.8	-2.2
Bone: cortical porosity	0.2	0.2	0.7	-0.2	-0.3	0.5	0.3	0.3	0.3	-0.4	-0.3	0.6	0.4	0.2	0.6	-0.2	-0.8
Bone: cortical porosity	0.7	0.8	2.0	-0.6	-0.8	0.4	0.8	0.8	0.8	-0.9	-0.9	1.1	1.0	0.7	1.1	-0.7	-1.4
Bone: cortical thickness	2.3	3.7	4.6	-1.8	-1.9	-1.2	2.1	1.9	1.9	-2.0	-2.0	2.1	2.1	1.8	2.1	-1.9	-2.1
Bone: cortical thickness	0.6	0.6	2.2	-0.8	-0.8	-1.5	1.2	0.6	0.6	-0.7	-0.5	0.8	0.6	0.6	0.7	-0.5	-0.8
Bone: cortical tissue density	1.1	1.5	2.5	-1.3	-1.2	-1.6	1.5	1.2	1.2	-1.2	-1.2	1.0	1.3	1.2	1.0	-1.1	-0.7
Condit. Reinf. active minus inactive responses	1.6	1.8	2.2	1.5	1.4	1.3	-1.3	-1.4	-1.3	1.4	1.4	-1.3	-1.3	-1.4	-1.2	1.4	1.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.6	0.6	0.0	-0.5	-0.7	-0.7	0.7	0.8	-0.6	-0.7	-0.7	-0.6	0.8	0.5
Condit. Reinf. active responses	1.7	2.1	4.6	1.7	1.5	2.1	-1.6	-1.5	-1.4	1.4	1.4	-1.3	-1.2	-1.5	-1.2	1.3	0.9
Condit. Reinf. inactive responses	0.8	0.9	4.3	1.1	1.0	2.1	-1.1	-0.8	-0.8	0.8	0.7	-0.7	-0.6	-0.8	-0.6	0.6	0.4
Incentive salience index mean	0.7	0.9	2.6	1.1	0.9	1.6	-1.0	-0.9	-0.8	0.9	0.9	-0.8	-0.7	-0.9	-0.7	0.8	0.5
Condit. Reinf. lever presses	0.2	0.3	3.2	0.2	0.0	1.8	-0.2	0.1	0.2	-0.0	-0.2	0.2	0.3	0.1	0.3	-0.3	-0.4
Condit. Reinf. active minus inactive responses	2.3	2.9	3.4	1.7	1.8	0.4	-1.6	-1.8	-1.8	1.7	1.8	-1.7	-1.8	-1.7	-1.7	1.8	1.7
Condit. Reinf. active-inactive response ratio	1.4	1.4	2.1	1.0	1.1	-0.6	-1.0	-1.2	-1.3	1.2	1.3	-1.3	-1.4	-1.1	-1.4	1.3	1.5
Condit. Reinf. active responses	1.1	1.5	1.8	1.3	1.3	0.7	-1.2	-1.3	-1.3	1.2	1.2	-1.2	-1.2	-1.3	-1.2	1.3	1.1
Condit. Reinf. inactive responses	0.1	0.1	0.6	0.4	0.4	0.8	-0.3	-0.3	-0.3	0.2	0.2	-0.2	-0.1	-0.4	-0.1	0.3	0.0
Condit. Reinf. lever presses	3.2	4.3	5.2	2.1	2.2	0.9	-2.0	-2.2	-2.2	2.1	2.2	-2.1	-2.1	-2.3	-2.1	2.3	1.9
Condit. Reinf. lever reinforcers received	1.0	1.4	1.7	1.2	1.3	0.4	-1.1	-1.3	-1.3	1.2	1.2	-1.1	-1.2	-1.3	-1.1	1.2	1.0
Conditioned reinforcement - actives	0.2	0.2	0.3	-0.3	-0.3	0.5	0.4	0.4	0.4	-0.4	-0.5	0.4	0.5	0.3	0.5	-0.4	-0.5
Conditioned reinforcement - inactives	0.6	0.7	1.7	-1.2	-1.0	-1.3	0.8	0.9	0.9	-0.8	-0.7	0.6	0.6	0.9	0.5	-0.7	-0.3
Conditioned locomotion	1.3	1.6	2.3	1.5	1.4	1.2	-1.2	-1.4	-1.4	1.3	1.3	-1.2	-1.1	-1.4	-1.1	1.2	1.0
Patch foraging indifference point 0 sec	4.6	7.4	8.7	-2.8	-2.8	-2.1	3.0	2.7	2.7	-2.8	-2.8	2.8	2.7	2.6	2.8	-2.5	-2.8
Patch foraging indifference point AUC	0.7	0.8	1.1	0.8	0.8	0.8	-1.1	-0.8	-0.8	0.9	0.9	-0.9	-0.9	-0.8	-0.9	0.8	0.9
Delay disc. indifference point, 0s delay	2.6	2.8	4.9	-1.4	-1.6	0.0	1.7	1.6	1.7	-1.7	-1.8	1.9	1.9	1.5	1.9	-1.7	-2.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.5	0.5	0.4	-0.4	-0.4	-0.4	0.4	0.4	-0.4	-0.4	-0.5	-0.3	0.5	0.2
Delay disc. indifference point, 2s delay	0.4	0.5	0.7	-0.6	-0.7	-0.0	0.8	0.7	0.7	-0.7	-0.8	0.7	0.8	0.7	0.8	-0.8	-0.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.4	-0.4	-0.3	0.5	0.5	0.5	-0.6	-0.5	0.6	0.5	0.4	0.6	-0.4	-0.8
Delay disc. indifference point, 4s delay	0.1	0.1	1.0	0.4	0.3	1.0	-0.2	-0.1	-0.2	0.1	-0.0	-0.0	0.1	-0.2	0.1	0.1	-0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.6	-0.1	-0.1	-0.8	0.2	0.0	-0.0	-0.1	0.0	-0.0	-0.0	-0.1	-0.0	0.2	0.0
Indifference point function ln k	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.7	0.5	0.5	-0.5	-0.5	0.5	0.5	0.4	0.5	-0.4	-0.5
Indifference point function log k	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.7	0.5	0.5	-0.5	-0.5	0.5	0.5	0.4	0.5	-0.4	-0.5
Patch foraging total patch changes 0 sec	4.2	6.8	8.1	-2.7	-2.7	-2.2	2.8	2.6	2.6	-2.7	-2.6	2.7	2.6	2.4	2.6	-2.4	-2.6
Patch foraging total patch changes 12 sec	1.3	1.6	3.3	-1.5	-1.4	-1.8	1.5	1.2	1.3	-1.2	-1.1	1.2	1.1	1.2	1.1	-1.0	-1.1
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.2	0.3	0.3	-0.2	-0.3	0.3	0.2	0.2	0.2	-0.2	-0.2
Patch foraging total patch changes 24 sec	0.6	0.7	0.9	-0.9	-0.9	-0.3	0.8	0.9	0.9	-0.9	-0.9	0.9	0.9	0.9	0.9	-0.9	-0.8
Patch foraging total patch changes 6 sec	2.1	3.1	3.6	-1.9	-1.9	-1.3	1.8	1.8	1.8	-1.8	-1.8	1.8	1.7	1.7	1.7	-1.6	-1.7
Patch foraging time to switch 0 sec	0.3	0.5	0.7	-0.5	-0.5	0.5	0.5	0.7	0.7	-0.7	-0.8	0.8	0.7	0.8	0.8	-0.9	-0.9
Patch foraging water rate 0 sec	0.3	0.5	2.4	-0.8	-0.8	-1.6	0.9	0.6	0.6	-0.5	-0.4	0.4	0.4	0.4	0.3	-0.3	-0.2
Patch foraging water rate 12 sec	0.5	0.7	3.1	-1.0	-0.9	-1.8	1.0	0.7	0.7	-0.7	-0.6	0.6	0.6	0.7	0.5	-0.6	-0.3
Patch foraging water rate 18 sec	0.8	1.1	1.9	0.5	0.6	-1.2	-0.6	-1.0	-0.9	1.0	1.1	-1.1	-1.2	-0.9	-1.3	1.1	1.4
Patch foraging water rate 24 sec	0.5	0.7	8.2	-0.7	-0.6	-2.9	0.8	0.1	0.2	-0.2	0.1	0.0	-0.2	0.2	-0.2	0.1	0.3
Patch foraging water rate 6 sec	1.0	1.4	2.0	0.9	1.0	-0.2	-1.1	-1.2	-1.2	1.2	1.3	-1.3	-1.4	-1.2	-1.4	1.3	1.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	2.3	0.9	0.9	1.5	-0.9	-0.7	-0.7	0.7	0.6	-0.5	-0.6	-0.8	-0.5	0.7	0.4
Distance traveled before self-admin	0.6	0.7	1.2	1.0	1.0	0.1	-0.5	-0.9	-1.0	0.8	0.8	-0.7	-0.6	-1.1	-0.7	1.0	0.6
Distance traveled after self-admin	0.1	0.1	0.3	0.4	0.3	-0.6	0.2	-0.3	-0.3	0.1	0.2	-0.1	0.0	-0.4	-0.1	0.4	0.1
Extensor digitorum longus weight	3.8	14.9	20.4	-4.5	-4.4	-4.1	4.1	4.0	4.0	-3.8	-3.7	3.6	3.4	4.0	3.4	-3.7	-3.0
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.0	0.1	0.1	0.2	0.1	-0.2	-0.3	0.1	0.2	0.2	0.1	-0.2	0.0
Bone: elastic work	1.2	1.5	2.2	-1.0	-1.0	-0.4	1.3	1.2	1.1	-1.4	-1.3	1.4	1.3	1.2	1.4	-1.2	-1.5
Bone: endosteal estimation	1.1	2.3	3.0	-1.5	-1.5	0.2	1.1	1.7	1.7	-1.6	-1.7	1.6	1.6	1.6	1.6	-1.7	-1.5
Bone: endosteal perimeter	0.1	0.2	0.7	0.1	-0.1	0.7	0.1	0.2	0.2	-0.3	-0.3	0.5	0.4	0.1	0.6	-0.2	-0.8
Epididymis fat weight	0.1	0.3	0.5	0.6	0.6	0.2	-0.6	-0.6	-0.6	0.5	0.6	-0.4	-0.7	-0.5	-0.4	0.6	0.2
Delta time in closed arm before/after self-admin	0.3	0.2	2.4	-0.5	-0.3	-1.5	0.2	0.0	0.0	0.0	0.2	-0.2	-0.3	0.1	-0.3	0.2	0.6
Delta time in open arm before/after self-admin	1.0	1.0	1.1	-1.0	-1.0	-0.2	0.9	1.1	1.1	-1.0	-1.1	1.0	1.0	1.0	1.0	-1.0	-1.1
Diff in mean of infusions in LGA sessions	2.0	2.2	2.9	1.6	1.6	1.1	-1.7	-1.6	-1.6	1.5	1.5	-1.4	-1.6	-1.5	-1.4	1.4	1.2
Delay discount exponential model param	0.0	0.0	0.1	0.1	0.1	0.0	-0.2	-0.2	-0.1	0.2	0.2	-0.2	-0.3	-0.0	-0.2	0.1	0.2
Extinction: sum of active levers before priming	4.9	4.9	5.8	2.2	2.2	0.8	-2.3	-2.3	-2.3	2.3	2.4	-2.3	-2.4	-2.1	-2.3	2.2	2.3
Active lever presses in extinction session 6	0.9	0.9	1.4	1.2	1.1	0.6	-0.9	-1.1	-1.1	1.0	1.0	-0.9	-0.9	-1.1	-0.9	0.9	0.6
Bone: final force	3.9	6.4	8.4	-2.4	-2.5	-0.8	2.4	2.6	2.6	-2.7	-2.7	2.8	2.7	2.4	2.8	-2.5	-2.9
Bone: final moment	3.8	6.1	8.1	-2.4	-2.4	-0.8	2.4	2.6	2.5	-2.6	-2.6	2.7	2.6	2.4	2.7	-2.4	-2.9
Food consumed during 24 hour testing period	0.5	0.5	0.8	-0.7	-0.7	-0.9	0.9	0.7	0.7	-0.8	-0.7	0.8	0.7	0.6	0.7	-0.6	-0.8
Glucose	1.5	2.3	3.0	-1.7	-1.7	-1.0	1.6	1.6	1.7	-1.6	-1.5	1.5	1.5	1.5	1.4	-1.4	-1.4
Heart weight	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	0.2	-0.0	-0.0	-0.0	-0.1	0.2	-0.0	-0.1	0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	0.3	0.3	0.1	-0.4	-0.4	-0.4	0.4	0.4	-0.4	-0.5	-0.3	-0.4	0.3	0.4
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.4	0.4	-0.0	-0.3	-0.5	-0.4	0.5	0.5	-0.6	-0.4	-0.5	-0.6	0.5	0.7
Intermittent access intake escalation	0.6	0.6	1.6	0.4	0.5	-0.6	-0.5	-0.7	-0.7	0.8	0.8	-1.0	-0.8	-0.6	-1.0	0.7	1.3
Intermittent access intake escalation 2	1.2	1.2	2.3	0.9	1.0	-0.1	-0.9	-1.1	-1.1	1.2	1.2	-1.3	-1.2	-0.9	-1.3	1.0	1.5
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.9	0.3	0.5	0.1	-0.9	-0.6	-0.6	0.7	0.7	-0.7	-0.9	-0.5	-0.8	0.6	0.8
Intermitt. access day 15 inactive lever presses	1.2	1.3	1.7	1.1	1.1	0.2	-1.1	-1.3	-1.2	1.2	1.3	-1.2	-1.3	-1.1	-1.3	1.2	1.2
Intermitt. access escalation Index	0.4	0.4	1.9	-0.3	-0.3	1.4	-0.0	0.5	0.5	-0.4	-0.6	0.6	0.5	0.3	0.7	-0.4	-0.8
Intermittent access day 1 total infusions	0.6	0.7	1.2	-0.8	-0.8	-0.3	0.7	0.8	0.8	-0.9	-0.9	1.0	0.8	0.7	1.0	-0.7	-1.1
Intermittent access day 15 total infusions	0.1	0.2	0.5	-0.5	-0.5	-0.7	0.5	0.4	0.4	-0.4	-0.3	0.4	0.3	0.3	0.3	-0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.5	0.6	0.7	-0.7	-0.8	-0.4	0.8	0.8	0.8	-0.8	-0.8	0.8	0.9	0.6	0.8	-0.6	-0.8
Intermittent access total infusions	0.6	0.6	0.7	-0.8	-0.8	-0.8	0.9	0.8	0.8	-0.8	-0.8	0.8	0.7	0.7	0.8	-0.7	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.0	0.1	0.2	-0.2	-0.0	-0.0	0.1	0.1	-0.0	-0.2	-0.1	-0.1	0.1	0.1
Intermittent access day 15 total locomotion	0.4	0.4	0.7	0.5	0.6	0.8	-0.9	-0.6	-0.6	0.7	0.6	-0.7	-0.7	-0.5	-0.7	0.5	0.8
Intermittent access total locomotion	0.2	0.2	0.6	0.4	0.5	0.8	-0.6	-0.4	-0.4	0.5	0.4	-0.4	-0.4	-0.4	-0.4	0.4	0.5
Intermittent access standard deviation	0.2	0.2	0.5	0.3	0.3	-0.1	-0.3	-0.4	-0.4	0.5	0.4	-0.6	-0.4	-0.4	-0.6	0.4	0.7
Left kidney weight	0.4	1.1	2.9	-0.7	-0.7	1.7	0.1	1.1	1.0	-0.9	-1.1	0.9	1.0	1.1	1.1	-1.2	-1.0
Right kidney weight	0.1	0.4	3.1	0.5	0.5	1.8	-1.0	-0.3	-0.3	0.5	0.3	-0.4	-0.4	-0.3	-0.4	0.2	0.4
Cocaine induced anxiety	0.6	0.7	1.9	1.2	1.0	1.4	-0.8	-0.9	-0.9	0.8	0.7	-0.7	-0.5	-0.8	-0.6	0.6	0.4
Post-drug Anxiety	0.2	0.2	1.6	0.2	0.1	1.3	0.1	0.1	0.1	-0.2	-0.3	0.4	0.5	0.1	0.5	-0.3	-0.7
Baseline Anxiety	0.0	0.0	0.1	-0.0	0.0	0.2	-0.2	-0.0	-0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.1	0.2	0.2
Tail length	5.9	17.9	21.3	4.2	4.2	3.6	-4.6	-4.3	-4.2	4.4	4.3	-4.3	-4.3	-4.2	-4.2	4.1	4.1
Length with tail	1.8	6.8	9.0	2.7	2.6	3.0	-3.0	-2.5	-2.5	2.6	2.5	-2.5	-2.5	-2.6	-2.4	2.5	2.3
Length without tail	0.3	0.7	1.1	-0.6	-0.7	0.2	0.7	0.9	0.8	-0.9	-1.0	1.0	1.0	0.7	1.0	-0.8	-1.1
Times rat made contact with spout	0.6	0.7	1.6	-1.0	-0.9	-1.3	1.0	0.8	0.8	-0.9	-0.8	0.9	0.7	0.7	0.8	-0.5	-0.8
Lifetime Intake	1.7	2.0	2.4	-1.4	-1.4	-0.9	1.5	1.4	1.4	-1.5	-1.5	1.5	1.4	1.3	1.5	-1.2	-1.5
Liver weight, left	1.1	1.8	2.7	-1.6	-1.5	-1.6	1.5	1.4	1.4	-1.3	-1.2	1.3	1.2	1.3	1.2	-1.2	-1.2
Liver weight, right	0.8	1.3	1.9	-1.3	-1.3	-0.5	0.9	1.3	1.3	-1.1	-1.2	1.0	1.1	1.4	1.0	-1.3	-0.7
Locomotor activity	3.1	5.0	11.5	2.4	2.3	3.4	-2.5	-2.2	-2.1	2.1	2.1	-1.9	-2.0	-2.3	-1.8	2.1	1.5
Locomotor testing distance	1.1	1.8	4.6	1.4	1.3	2.1	-1.5	-1.3	-1.2	1.3	1.2	-1.1	-1.2	-1.4	-1.0	1.3	0.8
Locomotor testing rearing	0.1	0.1	0.2	0.2	0.2	0.2	-0.4	-0.4	-0.3	0.4	0.5	-0.3	-0.5	-0.4	-0.4	0.4	0.2
Locomotion in novel chamber	0.4	0.5	0.6	-0.7	-0.7	-0.6	0.7	0.7	0.7	-0.7	-0.7	0.8	0.6	0.7	0.7	-0.7	-0.7
Locomotion in novel chamber post-restriction	3.0	3.7	4.4	2.1	2.0	1.5	-1.9	-2.1	-2.0	2.0	2.0	-1.9	-1.9	-1.9	-1.9	1.8	1.7
Fecal boli incidents, locomotor time 1	0.2	0.3	1.8	-0.6	-0.5	-1.3	0.5	0.4	0.4	-0.3	-0.3	0.1	0.2	0.4	0.0	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	1.5	0.5	0.4	1.2	-0.2	-0.2	-0.2	0.1	0.1	0.1	0.1	-0.3	0.1	0.1	-0.5
Time >=10cm from walls, locomotor time 1	1.3	1.3	1.7	-1.0	-1.1	-0.1	1.1	1.2	1.2	-1.2	-1.3	1.2	1.3	1.2	1.2	-1.2	-1.2
Bouts of movement, locomotor time 1	0.4	0.5	0.8	0.7	0.7	0.6	-0.9	-0.7	-0.7	0.7	0.7	-0.6	-0.8	-0.7	-0.6	0.7	0.5
Total resting periods, locomotor time 1	1.0	1.1	1.6	1.1	1.1	1.0	-1.3	-1.0	-1.0	1.1	1.0	-1.0	-1.1	-1.0	-1.0	1.0	0.9
Rest time, locomotor task time 1	0.3	0.3	0.4	0.6	0.6	0.7	-0.6	-0.5	-0.5	0.5	0.5	-0.5	-0.4	-0.5	-0.4	0.5	0.4
Distance moved, locomotor task time 1	1.3	1.5	2.1	-1.0	-1.1	-0.2	1.3	1.2	1.2	-1.3	-1.3	1.3	1.3	1.2	1.4	-1.2	-1.5
Vertical activity count, locomotor time 1	1.0	1.0	1.4	-1.1	-1.1	-1.1	1.2	1.0	1.0	-1.0	-0.9	1.0	0.9	0.9	0.9	-0.8	-1.0
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.1	-1.1	-1.0	-1.0	0.8	0.9	0.9	-0.8	-0.9	0.7	0.7	1.0	0.7	-0.9	-0.4
Bouts of movement, locomotor time 2	0.1	0.2	1.7	0.4	0.3	1.3	-0.3	-0.1	-0.1	0.1	0.1	-0.0	-0.0	-0.2	0.1	0.1	-0.2
Total resting periods, locomotor time 2	0.1	0.1	1.7	0.3	0.2	1.3	-0.2	-0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.2	-0.0	-0.3
Rest time, locomotor task time 2	0.1	0.1	0.5	0.1	-0.0	0.7	0.0	0.1	0.2	-0.2	-0.2	0.3	0.3	0.1	0.3	-0.2	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.0	0.1	-0.6	-0.1	-0.2	-0.2	0.2	0.3	-0.2	-0.3	-0.2	-0.3	0.3	0.3
Vertical activity count, locomotor time 2	0.4	0.4	1.9	-0.9	-0.8	-1.4	0.7	0.6	0.6	-0.5	-0.4	0.4	0.3	0.5	0.3	-0.3	-0.2
Light reinforcement 1	2.8	5.1	6.3	2.5	2.4	2.5	-2.4	-2.3	-2.3	2.3	2.2	-2.1	-2.1	-2.3	-2.0	2.2	1.9
Light reinforcement 2	0.7	1.0	1.5	1.2	1.2	0.6	-0.8	-1.1	-1.2	1.0	1.0	-0.9	-0.9	-1.0	-0.9	1.0	0.8
Bone: marrow area	0.9	2.1	2.7	-1.4	-1.4	0.3	1.0	1.6	1.6	-1.5	-1.6	1.5	1.5	1.6	1.5	-1.6	-1.4
Bone: maximum diameter	0.2	0.3	2.8	0.2	0.0	1.7	-0.2	0.2	0.2	-0.2	-0.3	0.4	0.4	0.1	0.5	-0.3	-0.6
Bone: maximum force	4.1	7.1	9.3	-2.5	-2.6	-1.0	2.6	2.7	2.7	-2.9	-2.8	2.9	2.8	2.6	2.9	-2.6	-3.0
Bone: maximum moment	4.0	7.0	9.1	-2.5	-2.6	-0.9	2.6	2.7	2.7	-2.8	-2.8	2.9	2.8	2.6	2.9	-2.6	-3.0
Mean time between licks in bursts	0.9	1.2	1.6	1.1	1.1	0.4	-1.1	-1.2	-1.2	1.1	1.2	-1.1	-1.2	-1.2	-1.1	1.3	1.0
Mean num. licks in bursts	0.5	0.6	1.2	0.9	0.9	1.1	-0.8	-0.7	-0.8	0.7	0.7	-0.7	-0.6	-0.9	-0.6	0.9	0.6
Cd content in liver	0.4	0.4	0.6	-0.6	-0.7	-0.5	0.7	0.6	0.6	-0.6	-0.6	0.7	0.6	0.6	0.6	-0.6	-0.7
Co content in liver	1.5	1.8	2.1	1.3	1.3	0.5	-1.3	-1.4	-1.4	1.4	1.4	-1.5	-1.4	-1.3	-1.4	1.4	1.4
Cu content in liver	2.5	3.1	5.0	-1.5	-1.6	-0.3	1.8	1.7	1.7	-1.8	-1.8	1.9	1.9	1.8	2.0	-1.9	-2.2
Fe content in liver	0.3	0.4	1.5	-0.7	-0.7	-1.2	0.8	0.6	0.6	-0.5	-0.5	0.4	0.5	0.6	0.3	-0.5	-0.2
K content in liver	0.2	0.2	1.2	0.5	0.4	1.1	-0.4	-0.3	-0.3	0.2	0.2	-0.0	-0.1	-0.2	0.1	0.1	-0.3
Mg content in liver	0.1	0.1	1.2	0.3	0.2	1.1	-0.3	0.0	-0.0	-0.1	-0.1	0.3	0.2	0.0	0.3	-0.2	-0.6
Mn content in liver	0.7	0.8	4.3	0.1	-0.1	2.1	0.0	0.5	0.5	-0.6	-0.7	0.8	0.8	0.5	1.0	-0.8	-1.3
Na content in liver	0.3	0.4	0.8	-0.3	-0.4	-0.5	0.7	0.5	0.5	-0.6	-0.6	0.7	0.7	0.5	0.7	-0.6	-0.9
Rb content in liver	1.6	2.0	3.1	-1.2	-1.3	-0.2	1.4	1.4	1.4	-1.5	-1.5	1.6	1.6	1.4	1.6	-1.5	-1.8
Se content in liver	0.0	0.0	0.1	0.2	0.2	0.3	-0.1	-0.1	-0.1	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.1	-0.1
Sr content in liver	0.7	0.7	1.3	0.5	0.6	-0.5	-0.8	-0.7	-0.7	0.8	0.8	-0.9	-1.0	-0.8	-1.0	1.0	1.1
Zn content in liver	3.8	4.2	5.3	1.8	1.9	-0.2	-1.8	-2.1	-2.1	2.1	2.2	-2.2	-2.3	-2.1	-2.3	2.3	2.3
Bone: minimum diameter	0.8	1.4	1.9	-1.0	-1.1	0.2	1.1	1.3	1.3	-1.3	-1.3	1.3	1.4	1.1	1.4	-1.2	-1.3
Time in familiar zone, hab. session 1	5.7	5.3	6.4	2.5	2.5	1.2	-2.3	-2.5	-2.5	2.3	2.5	-2.2	-2.4	-2.5	-2.2	2.5	1.9
Time in novel zone, hab. session 1	5.2	5.0	6.1	-2.3	-2.3	-0.6	2.2	2.4	2.4	-2.3	-2.4	2.2	2.4	2.4	2.3	-2.5	-2.1
Total zone transitions, hab. session 1	0.2	0.3	2.7	0.6	0.4	1.7	-0.4	-0.3	-0.3	0.3	0.2	-0.1	-0.0	-0.3	-0.0	0.1	-0.2
Total locomotion distance, hab. session 1	0.7	1.0	7.6	1.1	0.9	2.8	-1.0	-0.7	-0.6	0.7	0.5	-0.5	-0.3	-0.7	-0.4	0.4	0.1
Locomotion velocity, hab. session 1	0.9	1.2	6.7	1.3	1.1	2.6	-1.2	-1.0	-0.9	0.9	0.8	-0.8	-0.6	-0.9	-0.6	0.7	0.4
Time in familiar zone, hab. session 2	5.5	5.7	6.8	2.5	2.5	0.8	-2.3	-2.6	-2.6	2.4	2.5	-2.3	-2.5	-2.6	-2.3	2.6	2.1
Time in novel zone, hab. session 2	6.9	6.9	7.7	-2.7	-2.7	-1.1	2.7	2.8	2.8	-2.7	-2.8	2.6	2.8	2.8	2.6	-2.8	-2.5
Total zone transitions, hab. session 2	1.2	1.6	2.4	-1.0	-1.2	0.9	1.1	1.2	1.3	-1.2	-1.4	1.4	1.4	1.2	1.4	-1.3	-1.6
Total locomotion distance, hab. session 2	0.1	0.2	1.8	0.4	0.3	1.4	-0.3	-0.2	-0.2	0.2	0.1	-0.1	0.0	-0.2	-0.0	0.1	-0.1
Locomotion velocity, hab. session 2	0.2	0.2	2.7	0.5	0.3	1.6	-0.3	-0.2	-0.1	0.1	-0.0	-0.0	0.1	-0.2	0.1	-0.0	-0.3
Novel to familiar place preference ratio	3.8	3.9	4.8	-2.0	-2.2	-0.5	2.1	2.0	2.2	-2.0	-2.0	2.0	2.1	1.9	2.1	-2.0	-2.2
Novelty place preference	2.8	2.8	3.7	-1.6	-1.8	-0.4	1.8	1.7	1.8	-1.7	-1.7	1.8	1.8	1.6	1.8	-1.6	-1.9
Time in novel zone, NPP test	3.4	3.5	4.3	-1.9	-2.1	-0.6	2.0	1.9	2.0	-1.9	-1.9	1.9	2.0	1.8	2.0	-1.8	-2.1
Total zone transitions, NPP test	0.5	0.7	1.2	-0.7	-0.7	0.3	0.8	0.8	0.8	-0.9	-0.9	1.0	0.9	0.7	1.0	-0.8	-1.1
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.3	-0.5	0.7	0.5	0.6	0.6	-0.6	-0.7	0.7	0.8	0.5	0.8	-0.6	-0.9
Locomotion velocity, NPP test	0.1	0.1	0.8	0.0	-0.1	0.9	0.1	0.2	0.2	-0.3	-0.4	0.4	0.4	0.2	0.4	-0.3	-0.5
Intraocular pressure	0.9	1.3	2.0	1.0	1.0	-0.4	-0.8	-1.2	-1.2	1.1	1.3	-1.2	-1.2	-1.3	-1.2	1.4	1.2
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.3	-0.2	-0.0	0.2	0.3	0.2	-0.3	-0.3	0.3	0.3	0.4	0.3	-0.4	-0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.4	-0.4	0.2	0.4	0.5	0.4	-0.5	-0.5	0.5	0.5	0.6	0.6	-0.6	-0.6
Parametrial fat weight	0.1	0.1	0.3	0.4	0.5	-0.5	-0.1	-0.4	-0.5	0.2	0.3	-0.2	-0.3	-0.3	-0.2	0.3	0.1
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.1	0.2	-0.6	-0.3	-0.3	-0.3	0.3	0.4	-0.4	-0.5	-0.3	-0.4	0.5	0.5
Pavlov. Cond. magazine entry latency	1.4	1.8	2.2	1.5	1.4	0.7	-1.3	-1.5	-1.4	1.4	1.4	-1.4	-1.3	-1.4	-1.4	1.3	1.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.5	-0.6	-0.7	-0.5	0.7	0.5	0.6	-0.5	-0.5	0.5	0.6	0.5	0.5	-0.4	-0.6
Pavlov. Cond. index score	0.1	0.2	0.6	0.6	0.4	0.8	-0.3	-0.4	-0.4	0.4	0.3	-0.3	-0.2	-0.4	-0.3	0.3	0.1
Pavlov. Cond. latency score	0.1	0.2	1.1	0.5	0.4	1.1	-0.3	-0.3	-0.3	0.3	0.2	-0.2	-0.1	-0.3	-0.2	0.1	0.0
Pavlov. Cond. lever contacts	0.3	0.3	0.6	-0.2	-0.4	0.8	0.4	0.5	0.5	-0.4	-0.6	0.5	0.7	0.5	0.6	-0.6	-0.7
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	-0.8	-0.7	-0.4	0.7	0.7	0.7	-0.7	-0.7	0.7	0.7	0.7	0.7	-0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.4	0.5	0.3	-0.8	-0.6	-0.6	0.7	0.8	-0.7	-0.9	-0.7	-0.8	0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	0.7	0.5	0.8	-0.4	-0.6	-0.5	0.5	0.5	-0.4	-0.3	-0.5	-0.3	0.4	0.2
Pavlov. Cond. response bias	0.5	0.6	0.9	0.9	0.8	0.5	-0.7	-0.9	-0.8	0.8	0.8	-0.8	-0.8	-0.9	-0.7	0.8	0.6
Pavlov. Cond. lever latency	1.7	2.2	2.8	-1.6	-1.6	-1.5	1.6	1.5	1.5	-1.5	-1.5	1.4	1.4	1.7	1.3	-1.6	-1.2
Pavlov. Cond. magazine entry latency	2.1	2.4	3.0	1.7	1.7	1.5	-1.7	-1.6	-1.6	1.5	1.6	-1.4	-1.5	-1.6	-1.3	1.5	1.1
Pavlov. Cond. change in total contacts	0.7	1.0	1.4	1.1	1.1	0.8	-1.1	-1.1	-1.1	1.0	1.1	-0.9	-1.0	-1.2	-0.9	1.2	0.7
Pavlov. Cond. index score	2.0	2.6	3.2	1.7	1.7	1.4	-1.7	-1.7	-1.7	1.6	1.7	-1.5	-1.6	-1.8	-1.4	1.7	1.2
Pavlov. Cond. latency score	2.0	2.5	3.2	1.7	1.7	1.6	-1.7	-1.7	-1.6	1.6	1.6	-1.4	-1.5	-1.8	-1.4	1.7	1.1
Pavlov. Cond. lever contacts	1.6	2.2	2.7	1.5	1.5	1.1	-1.5	-1.5	-1.5	1.5	1.5	-1.4	-1.5	-1.6	-1.4	1.6	1.3
Pavlov. Cond. magazine entry number	1.7	2.1	2.7	-1.6	-1.6	-1.4	1.5	1.6	1.5	-1.4	-1.5	1.3	1.4	1.6	1.2	-1.5	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.9	-0.8	-0.8	0.7	0.7	0.7	-0.5	-0.5	0.3	0.5	0.7	0.3	-0.6	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	3.1	1.7	1.7	1.5	-1.7	-1.7	-1.6	1.6	1.6	-1.4	-1.5	-1.8	-1.4	1.7	1.2
Pavlov. Cond. response bias	2.4	3.3	3.8	1.9	1.9	1.3	-1.9	-1.9	-1.9	1.8	1.8	-1.8	-1.8	-2.0	-1.7	1.9	1.6
Time in closed arm before self-admin	0.7	0.8	1.3	-0.6	-0.7	0.2	0.8	0.9	0.9	-0.9	-0.9	0.9	1.0	1.0	1.0	-1.1	-0.9
Time in closed arm after self-admin	0.5	0.5	0.7	-0.7	-0.7	-0.5	0.8	0.7	0.7	-0.7	-0.7	0.7	0.8	0.8	0.7	-0.8	-0.4
Time in open arm before self-admin	0.3	0.3	0.7	0.5	0.5	-0.6	-0.3	-0.6	-0.6	0.5	0.6	-0.6	-0.5	-0.8	-0.6	0.9	0.4
Time in open arm after self-admin	0.6	0.6	1.8	-0.9	-0.9	-1.3	0.9	0.8	0.8	-0.7	-0.7	0.7	0.6	0.6	0.6	-0.5	-0.7
Bone: periosteal estimation	2.2	4.6	5.7	-1.9	-2.0	0.2	1.8	2.3	2.3	-2.2	-2.4	2.3	2.3	2.1	2.4	-2.2	-2.4
Bone: periosteal perimeter	0.6	1.1	2.5	-0.6	-0.8	0.4	0.9	0.9	0.9	-1.1	-1.1	1.3	1.2	0.8	1.3	-1.0	-1.6
Bone: post-yield work	0.3	0.4	0.6	-0.7	-0.7	0.2	0.4	0.8	0.8	-0.6	-0.7	0.5	0.6	0.7	0.6	-0.7	-0.4
Progressive ratio test 1 active lever presses	1.3	1.4	1.8	-1.3	-1.3	-1.1	1.2	1.2	1.3	-1.2	-1.1	1.1	1.1	1.1	1.1	-1.1	-1.1
Progressive ratio test 1 breakpoint	1.5	1.6	2.0	-1.4	-1.4	-1.0	1.3	1.3	1.4	-1.3	-1.2	1.3	1.2	1.2	1.3	-1.1	-1.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.3	-0.3	0.1	0.1	0.4	0.4	-0.3	-0.3	0.4	0.3	0.2	0.4	-0.2	-0.4
Progressive ratio test 2 active lever presses	0.7	0.7	0.9	-1.0	-1.0	-0.5	0.8	1.0	1.0	-0.9	-0.9	0.8	0.9	0.9	0.8	-0.8	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.6	-0.7	-0.7	0.1	0.6	0.8	0.8	-0.7	-0.8	0.7	0.8	0.6	0.8	-0.7	-0.7
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.4	-0.9	-0.9	-0.4	0.9	0.9	0.9	-1.0	-1.0	1.1	1.0	0.7	1.1	-0.8	-1.2
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	0.2	0.4	-0.3	-0.2	-0.2	0.2	0.1	-0.2	-0.2	-0.1	-0.2	0.1	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.3	0.2	0.6	-0.3	-0.2	-0.2	0.2	0.1	-0.2	-0.2	-0.2	-0.2	0.1	0.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.6	0.7	0.2	-0.5	-0.7	-0.7	0.6	0.6	-0.5	-0.6	-0.6	-0.5	0.6	0.5
Progressive ratio	0.8	0.9	1.3	-1.1	-1.1	-1.2	1.2	1.0	1.0	-1.0	-0.9	0.8	0.9	1.0	0.7	-0.9	-0.5
Food seeking constrained by brief footshock	1.7	2.1	2.7	1.6	1.5	0.8	-1.3	-1.6	-1.6	1.5	1.6	-1.4	-1.4	-1.5	-1.4	1.4	1.1
Seeking ratio, punishment vs. effort	2.2	2.7	3.3	1.8	1.8	1.4	-1.8	-1.8	-1.7	1.7	1.7	-1.5	-1.7	-1.7	-1.5	1.6	1.2
Retroperitoneal fat weight	1.7	5.6	7.5	-2.7	-2.6	-1.6	2.2	2.5	2.5	-2.4	-2.4	2.4	2.1	2.6	2.3	-2.4	-2.2
Reaction time number correct	0.5	0.7	3.9	-0.9	-0.8	-2.0	1.0	0.6	0.6	-0.7	-0.6	0.7	0.5	0.6	0.5	-0.4	-0.5
Reaction time mean minus median	1.8	2.3	3.4	1.7	1.6	1.8	-1.7	-1.5	-1.5	1.5	1.4	-1.5	-1.4	-1.5	-1.4	1.4	1.4
Reaction time mean minus median AUC	0.9	1.2	6.1	1.3	1.1	2.5	-1.3	-0.9	-0.9	0.9	0.7	-0.8	-0.7	-1.0	-0.6	0.8	0.5
Reaction time num false alarms	0.3	0.4	0.7	-0.9	-0.8	-0.7	0.6	0.7	0.7	-0.5	-0.6	0.4	0.5	0.6	0.4	-0.5	-0.3
Reaction time num false alarms AUC	0.2	0.3	0.7	-0.8	-0.7	-0.8	0.5	0.6	0.6	-0.4	-0.4	0.3	0.4	0.6	0.3	-0.4	-0.1
Reaction time trials correct on left	0.5	0.7	3.9	-0.9	-0.8	-2.0	1.0	0.6	0.6	-0.7	-0.6	0.7	0.5	0.6	0.5	-0.4	-0.5
Reaction time trials on left	0.5	0.7	3.6	-0.9	-0.8	-1.9	1.1	0.6	0.6	-0.7	-0.6	0.7	0.6	0.6	0.6	-0.4	-0.6
Reaction time mean	0.6	0.8	3.2	1.1	1.0	1.8	-1.1	-0.8	-0.8	0.8	0.7	-0.8	-0.6	-0.7	-0.7	0.5	0.6
Reaction time mean AUC	0.2	0.3	1.9	0.6	0.5	1.4	-0.6	-0.3	-0.3	0.4	0.2	-0.3	-0.2	-0.2	-0.3	0.1	0.3
Median of all reaction times	0.2	0.3	1.9	0.6	0.5	1.4	-0.6	-0.4	-0.4	0.4	0.3	-0.4	-0.3	-0.3	-0.3	0.1	0.3
Reaction time omissions	0.1	0.1	0.1	-0.2	-0.3	0.2	0.2	0.3	0.3	-0.3	-0.3	0.3	0.3	0.3	0.3	-0.3	-0.3
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.4	0.2	0.2	0.4	0.4	-0.2	-0.3	0.2	0.3	0.4	0.2	-0.3	-0.1
Reaction time premature initiation rate	2.3	3.1	3.7	1.7	1.8	1.0	-1.9	-1.8	-1.8	1.8	1.9	-1.8	-1.9	-1.7	-1.8	1.8	1.8
Reaction time premature initiations	1.4	2.0	2.8	1.2	1.3	-0.1	-1.4	-1.4	-1.5	1.4	1.6	-1.4	-1.7	-1.5	-1.5	1.6	1.5
Std. dev. reaction times	0.6	0.8	2.4	1.0	0.9	1.5	-1.0	-0.8	-0.8	0.8	0.7	-0.8	-0.7	-0.8	-0.7	0.6	0.7
Reaction time trials completed	0.5	0.7	3.6	-0.9	-0.8	-1.9	1.1	0.6	0.6	-0.7	-0.6	0.7	0.6	0.6	0.6	-0.4	-0.6
Reaction time trials AUC	0.5	0.7	4.4	-0.9	-0.8	-2.1	1.1	0.6	0.6	-0.7	-0.5	0.6	0.5	0.6	0.5	-0.4	-0.5
Run reversals in cocaine runway, females	1.0	0.9	1.7	1.3	1.2	0.6	-0.8	-1.2	-1.2	1.0	1.0	-0.8	-0.8	-1.0	-0.8	0.9	0.5
Run reversals in cocaine runway, males	1.4	1.4	3.5	1.3	1.2	1.9	-1.3	-1.1	-1.1	1.2	1.0	-1.1	-1.0	-1.1	-1.0	1.0	0.9
Latency to leave start box in cocaine runway	0.6	0.7	1.3	-0.5	-0.6	1.1	0.4	0.8	0.8	-0.8	-0.9	0.9	0.9	0.6	1.0	-0.7	-1.0
Latency to leave start box in cocaine runway, F	1.3	1.5	2.2	-0.8	-1.0	1.2	0.8	1.2	1.2	-1.2	-1.4	1.3	1.4	1.0	1.4	-1.2	-1.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.3	0.5	-0.4	-0.3	-0.4	-0.5	0.3	0.5	-0.4	-0.5	-0.5	-0.4	0.6	0.4
Std. dev. time between licks in bursts	0.2	0.2	2.1	0.4	0.4	1.5	-0.5	-0.3	-0.2	0.3	0.2	-0.1	-0.1	-0.2	-0.0	0.1	-0.1
Total sessions with >9 infusions	1.8	1.9	3.0	-1.1	-1.3	-0.1	1.5	1.4	1.4	-1.5	-1.5	1.6	1.7	1.1	1.6	-1.2	-1.7
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.3	-0.0	0.3	0.3	0.3	-0.3	-0.4	0.3	0.3	0.3	0.3	-0.3	-0.3
Short access day 10 total inactive lever presses	0.1	0.2	0.5	0.0	0.2	0.3	-0.7	-0.2	-0.2	0.4	0.3	-0.5	-0.6	-0.1	-0.5	0.2	0.7
Short access day 1 total infusions	2.8	3.0	4.0	-1.6	-1.7	-0.1	1.7	1.9	1.9	-1.8	-2.0	1.9	2.0	1.5	2.0	-1.6	-1.9
Short access day 10 total infusions	1.3	1.5	1.9	-1.2	-1.2	-1.0	1.3	1.2	1.2	-1.3	-1.2	1.3	1.2	1.1	1.3	-1.0	-1.4
Short access total infusions	3.6	4.0	5.1	-1.9	-2.0	-0.6	2.0	2.1	2.1	-2.1	-2.2	2.2	2.2	1.8	2.2	-1.8	-2.3
Short access day 1 locomotion	0.1	0.1	0.6	-0.1	-0.2	0.8	0.1	0.2	0.2	-0.1	-0.2	0.1	0.3	0.1	0.2	-0.1	-0.1
Short access day 10 total locomotion	1.8	2.0	2.8	1.3	1.5	1.2	-1.6	-1.4	-1.4	1.5	1.4	-1.6	-1.5	-1.1	-1.6	1.1	1.7
Short access total locomotion	0.1	0.1	0.9	0.2	0.2	1.0	-0.4	-0.1	-0.1	0.2	0.1	-0.2	-0.2	-0.3	-0.2	0.2	0.2
One hour access (0.3 mA shock)	0.6	0.7	0.8	-0.8	-0.8	-0.7	0.9	0.8	0.8	-0.9	-0.9	0.9	0.8	0.9	0.9	-0.9	-0.9
Compulsive drug intake	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.7	0.5	0.5	-0.6	-0.6	0.6	0.6	0.6	0.6	-0.6	-0.6
One hour access (shock baseline)	0.1	0.1	0.5	-0.3	-0.2	-0.7	0.3	0.2	0.1	-0.2	-0.2	0.2	0.1	0.2	0.1	-0.1	-0.2
Social response proportion	0.6	0.6	1.3	0.9	0.9	1.1	-0.9	-0.7	-0.8	0.8	0.7	-0.7	-0.6	-0.7	-0.6	0.6	0.6
Social responses	7.3	9.3	12.9	3.5	3.4	3.6	-3.4	-3.1	-3.1	3.0	2.9	-2.9	-2.8	-3.0	-2.7	2.7	2.5
Social time	0.4	0.5	1.0	-1.0	-0.9	-0.4	0.6	0.9	0.9	-0.7	-0.8	0.6	0.6	0.9	0.5	-0.8	-0.3
Soleus weight	5.1	15.0	19.4	-4.4	-4.3	-3.2	4.0	4.2	4.2	-3.9	-3.9	3.7	3.7	4.0	3.5	-3.8	-3.1
Bone: stiffness	5.4	8.5	9.8	-3.0	-3.0	-1.5	3.0	3.0	3.0	-3.1	-3.0	3.1	3.0	2.9	3.1	-2.8	-3.1
Tibialis anterior weight	0.9	3.0	4.4	-2.1	-2.1	-0.5	1.5	2.0	2.0	-1.7	-1.8	1.7	1.6	1.9	1.7	-1.7	-1.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	2.9	0.6	0.4	1.7	-0.4	-0.2	-0.2	0.2	0.1	-0.1	0.1	-0.0	0.1	-0.2	0.0
Time to tail flick, vehicle, after self-admin	0.8	0.8	1.2	0.8	0.9	0.1	-1.0	-0.9	-0.9	0.9	1.1	-0.9	-1.1	-1.0	-0.9	1.1	0.7
Time to tail flick, test, before self-admin	0.5	0.5	4.3	0.7	0.6	2.1	-0.8	-0.4	-0.4	0.5	0.3	-0.4	-0.3	-0.4	-0.3	0.2	0.2
Time to tail flick, test, after self-admin	0.2	0.2	1.2	0.0	-0.1	1.1	0.1	0.2	0.2	-0.3	-0.3	0.4	0.4	0.4	0.4	-0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	2.2	-0.3	-0.2	-1.5	0.1	-0.0	-0.1	0.1	0.2	-0.2	-0.4	-0.1	-0.3	0.3	0.2
Delta time to tail flick, test, before/after SA	0.3	0.2	0.4	0.4	0.5	-0.6	-0.2	-0.6	-0.6	0.4	0.6	-0.4	-0.5	-0.4	-0.5	0.5	0.5
Tibia length	1.5	4.1	4.7	2.0	2.1	1.8	-2.2	-2.0	-2.1	2.1	2.0	-2.1	-2.0	-2.0	-2.0	1.9	2.1
Ambulatory time before self-admin	0.2	0.2	0.5	0.5	0.5	-0.1	-0.1	-0.5	-0.5	0.3	0.4	-0.2	-0.3	-0.7	-0.2	0.6	0.0
Ambulatory time after self-admin	0.1	0.1	0.6	0.1	0.1	-0.8	0.5	-0.1	-0.1	-0.2	-0.0	0.2	0.2	-0.1	0.2	0.1	-0.3
Bone: tissue strength	5.5	5.4	6.1	-2.3	-2.3	-1.6	2.3	2.4	2.3	-2.5	-2.4	2.4	2.4	2.3	2.4	-2.3	-2.3
Total heroin consumption	1.7	2.0	3.0	1.7	1.6	1.4	-1.5	-1.6	-1.6	1.4	1.5	-1.2	-1.3	-1.4	-1.2	1.3	0.9
Bone: trabecular number	0.2	0.3	3.0	0.7	0.5	1.7	-0.4	-0.3	-0.3	0.3	0.1	-0.2	0.0	-0.4	-0.1	0.2	0.0
Bone: trabecular spacing	0.5	0.6	4.0	0.0	0.2	-2.0	-0.2	-0.5	-0.5	0.5	0.7	-0.7	-0.9	-0.4	-0.9	0.6	1.0
Bone: trabecular thickness	2.2	2.7	4.2	-1.0	-1.3	2.0	1.1	1.6	1.6	-1.5	-1.8	1.7	2.0	1.3	1.9	-1.6	-2.0
Bone: trabecular tissue density	4.5	6.4	9.7	-2.9	-2.8	-3.1	2.8	2.5	2.5	-2.5	-2.3	2.4	2.2	2.5	2.2	-2.3	-2.1
Water consumed over 24 hours	1.7	2.1	3.0	-1.3	-1.4	-0.3	1.5	1.4	1.4	-1.5	-1.5	1.6	1.6	1.4	1.6	-1.5	-1.7
Number of responses in last shaping day	0.5	0.5	0.6	0.8	0.7	0.7	-0.8	-0.7	-0.7	0.7	0.7	-0.7	-0.7	-0.8	-0.7	0.7	0.6