Hub : Genes

Hrh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Hrh1 0.02 0.01 5.3e-05 0.02 0.02 0.03 0.02 1.8e-04 5.1e-04 9.0e-05 2.0e-04
2 Brain mRNA stability Hrh1 0.07 0.04 7.2e-09 0.08 0.1 0.09 0.09 3.8e-08 3.0e-09 2.1e-08 8.2e-09
3 BLA mRNA stability Hrh1 0.06 0.04 7.0e-03 0.04 0.03 0.01 0.02 4.5e-03 8.0e-03 6.9e-02 1.9e-02
4 PL mRNA stability Hrh1 0.03 0.02 3.0e-04 0.04 0.03 0.03 0.03 5.5e-05 2.3e-04 3.0e-04 2.5e-04
5 PL intron excision ratio chr4_149121009_149201504 0.03 0.02 1.8e-03 0.01 0.01 0.01 0 3.7e-02 3.1e-02 7.1e-02 1.3e-01
6 PL alternative TSS NM_017018.2 0.06 0.04 4.9e-04 0.01 0.02 0.02 0.01 7.1e-02 5.2e-03 5.3e-03 6.1e-02
7 PL alternative TSS XM_039107019.2 0.06 0.04 2.5e-04 0.01 0.02 0.02 0.01 1.9e-02 1.5e-03 2.3e-03 1.6e-02
8 PL intron excision ratio chr4_149120573_149201504 0.05 0.03 9.8e-05 0.02 0.03 0.02 0.02 3.7e-03 1.2e-04 1.1e-03 4.1e-03
9 PL isoform ratio NM_017018.2 0.05 0.03 3.5e-04 0.01 0.02 0.02 0.01 5.1e-02 4.3e-03 2.1e-03 3.7e-02
10 PL isoform ratio XM_039107019.2 0.05 0.03 1.7e-04 0.01 0.02 0.02 0.01 3.1e-02 2.5e-03 2.0e-03 2.6e-02
11 NAcc gene expression Hrh1 0.17 0.06 0.0e+00 0.2 0.2 0.21 0.21 2.3e-30 1.1e-29 9.1e-31 5.0e-31
12 pVTA gene expression Hrh1 0.06 0.03 4.8e-05 0.05 0.07 0.06 0.06 4.9e-05 4.2e-06 1.3e-05 1.6e-05
13 Adipose gene expression Hrh1 0.07 0.04 8.2e-04 0.03 0.03 0.03 0.03 2.2e-04 1.9e-04 3.5e-04 4.2e-04
14 BLA gene expression Hrh1 0.28 0.09 1.5e-13 0.23 0.26 0.26 0.25 1.5e-12 8.1e-14 5.3e-14 2.0e-13
15 OFC gene expression Hrh1 0.35 0.12 3.6e-07 0.14 0.27 0.26 0.25 4.2e-04 3.4e-07 8.6e-07 1.2e-06
16 LHb gene expression Hrh1 0.23 0.11 1.1e-03 0.05 0.04 0.05 0.01 2.8e-02 3.2e-02 2.1e-02 1.5e-01
17 IC gene expression Hrh1 0.31 0.11 7.7e-07 0.02 0.16 0.16 0.12 5.9e-02 3.2e-07 2.8e-07 6.8e-06
18 Brain gene expression Hrh1 0.45 0.1 0.0e+00 0.28 0.4 0.4 0.4 3.3e-26 6.5e-40 4.0e-39 2.3e-39
19 IL gene expression Hrh1 0.41 0.13 5.1e-06 0.09 0.18 0.16 0.17 3.0e-03 3.4e-05 1.4e-04 5.3e-05
20 PL gene expression Hrh1 0.4 0.09 0.0e+00 0.26 0.42 0.42 0.41 1.7e-28 2.5e-49 6.7e-49 5.0e-48

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.71.25.51.50.70.5-0.80.1-0.80.9-0.8-1.11.0-0.0-0.80.0-1.1-1.2-2.3-1.5-1.3-1.2-1.4
Area under the delay curve0.30.31.0-0.3-0.50.0-0.00.7-0.60.6-0.8-0.91.0-0.6-0.6-0.5-0.4-0.5-0.5-0.4-0.1-0.0-0.3
BMI with tail1.24.09.83.13.02.72.9-2.52.4-2.32.22.2-2.11.92.10.41.7-1.1-1.2-0.90.20.50.3
BMI without tail0.20.71.40.91.00.71.0-1.21.0-1.00.91.2-1.00.90.7-0.60.8-0.4-0.4-0.20.40.60.5
Body weight0.93.98.62.92.92.42.5-2.82.5-2.42.32.3-2.12.02.1-0.31.5-0.7-1.0-0.60.81.00.7
Weight adjusted by age0.20.30.8-0.9-0.6-0.7-0.40.8-0.60.6-0.8-0.80.7-0.7-0.6-0.1-0.3-0.50.0-0.3-0.5-0.4-0.4
Bone surface0.40.81.70.4-0.0-0.2-1.20.6-0.90.9-0.9-1.11.1-0.5-0.9-0.1-1.1-0.7-1.3-0.9-1.0-0.9-1.0
Bone volume0.30.62.71.20.70.6-0.7-0.1-0.40.4-0.3-0.70.70.1-0.40.1-0.7-0.8-1.6-1.0-0.9-0.9-1.0
Breakpoint value in progressive ratio session1.21.45.71.82.11.31.4-1.70.9-0.80.9-0.00.11.20.9-1.00.3-1.2-2.4-0.90.10.4-0.1
Number of licking bursts0.20.30.9-0.1-0.1-0.6-0.5-0.2-0.70.7-0.3-0.90.90.0-0.4-1.0-0.40.2-0.4-0.10.40.30.2
Context. condit. distance diff. score3.44.18.12.52.42.52.1-2.52.9-2.82.62.8-2.72.02.30.92.0-0.10.70.00.40.50.7
Locomotion velocity, session 10.30.30.7-0.8-0.4-0.50.0-0.10.4-0.50.30.7-0.80.50.4-0.80.70.5-0.00.70.50.70.8
Locomotion distance, session 10.30.41.7-0.9-0.6-0.6-0.6-0.20.1-0.20.10.5-0.50.60.1-1.30.50.70.60.70.81.01.0
Locomotion velocity, session 20.60.72.2-1.5-1.4-0.9-1.10.9-0.80.8-0.8-0.90.9-0.2-0.6-1.0-0.10.60.20.70.30.40.4
Locomotion distance, session 20.71.04.8-1.3-1.1-1.3-1.00.1-0.60.5-0.3-0.70.70.5-0.2-2.20.21.00.50.81.21.31.2
Locomotion velocity, session 30.81.02.4-0.3-1.0-0.5-0.91.6-1.21.2-1.4-0.60.6-1.3-1.30.6-1.1-0.7-0.4-0.7-1.1-1.0-1.0
Locomotion distance, session 30.80.91.60.1-0.9-0.6-1.11.2-1.11.1-1.3-0.90.9-1.0-1.2-0.1-1.1-0.8-0.7-1.0-1.0-0.8-0.8
Stereotopy head waving bouts, day 31.01.24.3-2.1-1.4-1.2-0.60.5-0.50.3-0.3-0.60.70.10.0-1.40.51.51.31.61.51.41.3
Stereotopy head waving duration, day 31.41.75.3-2.1-1.4-0.8-0.30.20.4-0.50.30.4-0.30.40.6-1.21.31.82.32.01.71.71.8
Locomotion velocity, session 70.50.61.40.0-0.4-0.3-1.00.8-0.70.7-0.8-0.20.1-0.8-0.90.6-1.0-0.7-0.8-0.6-1.2-1.1-1.0
Locomotion distance, session 70.81.03.21.50.80.6-0.10.20.1-0.0-0.20.5-0.6-0.5-0.41.1-0.8-1.7-1.3-1.5-1.8-1.5-1.4
Stereotopy head waving bouts, day 71.01.12.5-1.5-1.6-1.1-1.41.2-1.31.2-1.0-1.51.5-0.6-0.8-0.6-0.51.00.60.70.20.10.3
Stereotopy head waving duration, day 71.01.22.8-1.7-1.6-0.9-1.30.8-0.90.7-0.6-1.41.4-0.0-0.2-1.10.21.61.31.30.80.80.9
Locomotion velocity, session 80.70.82.10.10.50.20.2-1.30.6-0.71.00.6-0.61.40.9-1.11.01.0-0.00.81.21.21.2
Locomotion distance, session 82.43.56.51.71.71.81.3-2.52.5-2.52.42.4-2.32.52.1-0.72.20.70.90.61.31.51.6
Degree of sensitization distance0.90.93.50.91.11.00.6-0.91.3-1.21.11.8-1.90.70.81.00.6-0.3-0.00.0-0.5-0.4-0.2
Degree of sensitization stereotypy0.30.41.6-0.6-0.7-0.3-0.70.6-0.90.8-0.6-1.31.2-0.3-0.4-0.1-0.40.50.20.2-0.0-0.1-0.0
Conditioned locomotion1.21.45.81.11.20.20.6-0.2-0.80.9-0.6-0.20.1-0.5-0.91.0-1.5-1.7-2.4-1.7-1.2-1.4-1.7
Cocaine response after cond. corrected1.41.64.8-1.7-1.9-1.9-1.90.5-0.60.4-0.4-0.40.50.0-0.5-1.80.31.62.21.21.21.31.5
Cocaine response after cond. not corrected2.42.87.9-2.4-2.8-2.8-2.61.6-1.51.3-1.3-1.21.3-1.0-1.3-1.6-0.41.42.21.10.80.81.0
Cocaine response before conditioning0.91.12.9-1.0-1.4-1.3-0.81.7-1.21.2-1.4-1.21.2-1.6-1.20.3-1.1-0.30.1-0.2-0.7-0.7-0.7
Saline control response4.15.59.7-0.9-1.8-1.8-2.13.1-2.72.8-3.0-1.91.8-3.0-3.11.1-2.8-2.0-1.1-2.1-2.7-2.5-2.4
Bone: connectivity density0.20.21.60.60.40.4-0.7-0.1-0.20.2-0.3-0.30.30.3-0.3-0.5-0.3-0.6-1.3-0.5-0.5-0.3-0.5
Bone: cortical apparent density0.00.00.2-0.1-0.2-0.4-0.20.1-0.10.1-0.0-0.10.1-0.20.00.2-0.00.3-0.10.20.0-0.10.0
Bone: cortical area0.10.20.5-0.3-0.2-0.10.0-0.20.5-0.50.30.2-0.10.40.2-0.60.50.30.70.40.40.60.6
Bone: cortical porosity0.30.31.7-0.4-0.30.4-0.30.00.0-0.10.3-0.40.40.40.50.50.41.30.91.10.40.10.4
Bone: cortical porosity0.30.41.20.10.20.90.2-0.40.4-0.50.7-0.10.10.80.90.50.71.10.70.90.50.30.4
Bone: cortical thickness0.30.51.7-0.7-0.5-0.1-0.1-0.20.6-0.60.50.2-0.10.60.5-0.50.91.01.31.10.80.81.0
Bone: cortical thickness0.30.30.9-0.5-0.6-0.7-0.40.9-0.40.5-0.60.1-0.2-0.9-0.70.7-0.6-0.4-0.5-0.2-0.6-0.7-0.6
Bone: cortical tissue density0.00.00.1-0.0-0.1-0.4-0.10.1-0.10.10.0-0.10.1-0.20.10.2-0.00.3-0.10.20.1-0.1-0.0
Condit. Reinf. active minus inactive responses2.32.65.7-1.1-1.9-2.2-2.12.3-1.81.8-1.8-1.00.9-2.4-2.00.9-1.9-0.40.5-0.7-1.4-1.5-1.2
Condit. Reinf. active-inactive response ratio2.72.97.2-1.8-2.3-2.7-2.42.3-2.02.0-1.9-1.10.9-2.4-2.00.6-1.90.10.9-0.2-1.1-1.2-0.9
Condit. Reinf. active responses1.01.32.9-0.4-1.0-1.1-1.01.5-1.11.2-1.2-0.70.6-1.7-1.31.1-1.3-0.70.0-0.9-1.4-1.5-1.2
Condit. Reinf. inactive responses0.40.51.61.11.01.30.9-0.50.5-0.40.30.2-0.10.50.20.10.2-1.0-1.0-1.0-0.5-0.3-0.4
Incentive salience index mean1.61.94.2-1.5-1.9-2.0-2.11.9-1.61.6-1.5-1.21.1-1.9-1.50.5-1.40.40.9-0.0-0.8-0.9-0.5
Condit. Reinf. lever presses0.60.82.3-1.5-1.2-1.0-1.10.5-0.80.7-0.3-1.21.2-0.3-0.2-0.4-0.11.41.41.10.60.40.7
Condit. Reinf. active minus inactive responses0.50.62.8-1.5-1.4-0.9-1.71.2-0.30.3-0.70.0-0.0-0.7-0.70.1-0.20.41.00.7-0.5-0.30.0
Condit. Reinf. active-inactive response ratio0.50.62.3-0.9-0.6-0.2-0.60.00.8-0.80.51.0-0.90.20.5-0.20.90.81.51.20.40.50.8
Condit. Reinf. active responses0.50.72.1-1.2-1.2-1.1-1.41.3-0.70.7-0.9-0.20.1-1.1-1.00.5-0.7-0.10.40.1-0.8-0.7-0.5
Condit. Reinf. inactive responses1.72.24.2-0.1-0.4-1.0-0.91.4-1.71.8-1.7-1.00.9-1.8-1.81.0-2.0-1.5-1.6-1.7-1.7-1.8-1.9
Condit. Reinf. lever presses0.10.10.4-0.5-0.5-0.6-0.60.4-0.30.4-0.5-0.10.2-0.4-0.6-0.1-0.3-0.30.4-0.2-0.2-0.1-0.1
Condit. Reinf. lever reinforcers received0.60.93.1-1.4-1.5-1.3-1.81.5-0.80.8-1.1-0.20.1-1.0-1.20.2-0.7-0.00.60.1-0.8-0.6-0.4
Conditioned reinforcement - actives0.91.65.01.71.51.61.3-0.41.1-1.00.71.4-1.30.20.62.20.4-1.6-0.1-1.3-1.7-1.4-1.1
Conditioned reinforcement - inactives0.20.30.90.90.50.8-0.0-0.30.8-0.70.50.6-0.70.50.40.20.5-0.6-0.0-0.7-0.9-0.5-0.2
Conditioned locomotion0.40.62.70.50.30.7-0.1-0.10.9-0.90.41.5-1.60.20.30.40.5-0.80.1-0.6-1.1-0.6-0.2
Patch foraging indifference point 0 sec0.20.31.00.40.60.2-0.0-0.10.3-0.20.10.5-0.7-0.2-0.21.0-0.2-0.8-0.1-0.8-0.9-0.9-0.8
Patch foraging indifference point AUC0.81.23.7-1.5-1.7-1.9-1.11.5-1.21.2-1.2-0.00.0-1.9-1.30.1-0.90.20.9-0.10.0-0.1-0.1
Delay disc. indifference point, 0s delay0.60.71.80.50.20.50.50.8-0.40.5-0.7-0.40.4-0.9-0.60.9-0.7-1.4-0.9-1.2-1.2-1.1-1.1
Delay disc. indifference point, 16s delay0.00.00.2-0.4-0.30.4-0.00.30.1-0.1-0.1-0.30.3-0.00.0-0.10.10.0-0.00.3-0.10.00.1
Delay disc. indifference point, 2s delay0.40.41.51.10.61.20.90.00.3-0.2-0.1-0.20.20.20.00.10.3-1.2-0.8-1.2-0.7-0.4-0.6
Delay disc. indifference point, 24s delay0.70.81.6-1.2-1.2-1.0-1.00.8-1.11.0-1.0-1.21.3-0.6-0.7-1.2-0.70.4-0.00.40.50.50.3
Delay disc. indifference point, 4s delay0.20.20.7-0.1-0.20.20.10.5-0.60.6-0.7-0.80.9-0.5-0.5-0.1-0.4-0.5-0.4-0.4-0.2-0.2-0.4
Delay disc. indifference point, 8s delay0.50.51.7-0.7-0.9-0.7-0.50.9-0.80.8-1.0-1.11.1-0.6-0.7-1.3-0.5-0.3-0.5-0.30.20.40.1
Indifference point function ln k1.22.15.21.51.91.91.5-2.21.7-1.81.90.6-0.72.31.9-0.61.60.3-0.20.30.70.80.8
Indifference point function log k1.22.15.21.51.91.91.5-2.21.7-1.81.90.6-0.72.31.9-0.61.60.3-0.20.30.70.80.8
Patch foraging total patch changes 0 sec0.20.30.80.60.70.30.3-0.30.6-0.50.40.7-0.80.00.20.90.1-0.60.1-0.6-0.7-0.7-0.5
Patch foraging total patch changes 12 sec0.40.51.1-1.0-0.8-1.0-1.00.8-0.30.4-0.50.6-0.8-1.0-0.80.9-0.6-0.00.6-0.1-0.6-0.7-0.5
Patch foraging total patch changes 18 sec0.91.34.0-0.8-1.3-1.8-1.11.6-1.31.3-1.4-0.20.1-2.0-1.50.7-1.3-0.40.4-0.7-0.8-0.9-0.8
Patch foraging total patch changes 24 sec0.50.92.90.0-0.5-0.5-0.11.3-0.50.6-0.90.2-0.2-1.7-1.01.7-1.0-1.00.4-1.1-1.2-1.3-1.2
Patch foraging total patch changes 6 sec0.40.61.80.90.90.80.5-0.50.8-0.70.51.2-1.3-0.00.21.20.1-0.80.0-0.7-0.8-0.7-0.6
Patch foraging time to switch 0 sec0.30.52.81.31.11.20.8-0.50.1-0.10.1-0.50.60.80.20.1-0.2-0.6-1.7-0.4-0.3-0.3-0.6
Patch foraging water rate 0 sec0.30.62.9-0.9-0.4-0.1-0.4-0.10.5-0.60.70.5-0.60.10.80.70.81.41.71.30.40.20.7
Patch foraging water rate 12 sec0.10.20.40.30.2-0.00.1-0.60.5-0.50.60.6-0.60.30.5-0.30.50.10.7-0.10.10.30.4
Patch foraging water rate 18 sec0.20.30.80.50.60.70.8-0.50.8-0.70.80.2-0.20.20.80.90.50.30.40.30.1-0.10.1
Patch foraging water rate 24 sec0.20.31.8-0.1-0.2-0.1-0.3-0.30.6-0.60.60.6-0.70.20.50.10.50.61.30.40.10.20.6
Patch foraging water rate 6 sec0.10.20.6-0.6-0.2-0.3-0.5-0.30.2-0.20.40.2-0.20.20.4-0.30.40.80.70.70.40.40.6
Seeking ratio, delayed vs. immediate footshock0.91.12.90.91.10.91.7-1.21.5-1.51.21.7-1.60.91.20.11.0-0.40.1-0.10.50.70.6
Distance traveled before self-admin0.30.51.8-1.3-1.3-0.8-1.20.7-0.20.2-0.5-0.0-0.10.2-0.5-1.10.10.40.10.60.20.40.5
Distance traveled after self-admin0.40.61.5-0.4-0.7-0.6-0.31.2-0.50.6-0.70.1-0.1-1.2-0.71.2-0.8-0.50.1-0.5-1.0-1.0-0.8
Extensor digitorum longus weight3.513.632.24.65.25.45.7-4.74.7-4.54.34.0-3.83.94.21.03.3-1.2-0.5-0.51.11.41.0
Bone: elastic displacement1.41.73.40.70.0-0.6-0.21.0-1.31.4-1.4-0.80.8-1.4-1.50.8-1.8-1.7-1.6-1.8-1.4-1.5-1.7
Bone: elastic work0.20.31.50.90.60.20.5-0.10.00.1-0.30.2-0.10.0-0.4-0.3-0.5-1.2-1.1-1.2-0.3-0.1-0.5
Bone: endosteal estimation0.10.30.80.90.80.80.5-0.30.1-0.00.0-0.10.10.20.00.1-0.2-0.8-0.9-0.8-0.4-0.3-0.5
Bone: endosteal perimeter0.30.62.00.2-0.1-0.3-0.30.5-0.70.8-0.9-0.40.4-0.7-1.1-0.3-1.1-1.4-1.0-1.4-0.8-0.6-0.8
Epididymis fat weight0.20.62.71.10.80.20.6-0.0-0.30.4-0.5-0.40.5-0.4-0.5-0.1-0.7-1.6-1.5-1.4-0.8-0.6-0.9
Delta time in closed arm before/after self-admin1.41.33.6-0.10.31.10.1-1.11.3-1.41.30.8-0.81.91.3-0.61.71.20.91.50.81.01.2
Delta time in open arm before/after self-admin0.40.41.1-0.4-0.3-0.60.2-0.1-0.60.5-0.2-1.11.0-0.2-0.1-1.0-0.30.6-0.30.21.10.80.5
Diff in mean of infusions in LGA sessions0.50.72.61.10.80.20.2-0.2-0.40.5-0.4-0.30.4-0.1-0.60.1-0.7-1.4-1.6-1.6-0.9-0.9-1.0
Delay discount exponential model param0.30.41.20.40.60.10.1-0.80.7-0.70.91.1-1.10.60.60.70.50.50.50.40.1-0.00.2
Extinction: sum of active levers before priming0.30.41.50.50.61.0-0.0-0.1-0.10.1-0.2-0.60.60.7-0.10.1-0.2-0.8-1.2-0.7-0.8-0.6-0.7
Active lever presses in extinction session 62.12.14.11.41.72.01.5-1.82.0-2.01.81.5-1.31.91.9-0.21.8-0.0-0.20.30.50.80.7
Bone: final force0.50.92.00.60.71.21.0-0.91.4-1.41.20.9-0.81.01.30.41.20.50.80.60.50.50.6
Bone: final moment0.50.71.70.90.91.21.0-0.91.3-1.31.10.8-0.70.91.10.61.00.20.60.30.20.20.4
Food consumed during 24 hour testing period0.20.31.4-0.3-0.6-0.8-0.20.7-0.40.5-0.70.00.1-1.2-0.8-0.1-0.6-0.8-0.1-0.7-0.3-0.2-0.3
Glucose1.11.74.82.22.21.31.5-1.61.3-1.21.21.9-1.80.80.81.00.4-1.2-0.9-1.3-0.5-0.4-0.5
Heart weight0.20.20.80.20.2-0.40.9-0.40.5-0.50.30.8-0.8-0.20.2-0.30.3-0.30.5-0.20.60.60.4
Delay discount hyperbolic model param0.20.30.90.10.3-0.1-0.1-0.60.5-0.50.70.9-1.00.50.50.50.40.60.60.50.10.00.3
Intermittent access intake day 1-15 change0.91.85.2-0.41.11.41.4-1.22.0-1.91.72.1-2.31.11.60.71.60.10.90.60.20.40.7
Intermittent access intake escalation1.02.05.7-0.11.41.71.5-1.42.1-2.01.72.2-2.41.41.61.01.5-0.10.40.50.00.20.4
Intermittent access intake escalation 22.83.27.20.51.61.61.9-2.12.6-2.62.42.6-2.71.92.3-0.22.00.50.50.91.11.31.4
Intermitt. access day 1 inactive lever presses0.31.13.3-1.7-1.8-1.6-1.71.2-1.00.8-0.8-0.70.5-1.0-0.6-0.7-0.20.81.50.5-0.20.00.4
Intermitt. access day 15 inactive lever presses0.20.52.3-1.4-1.2-0.8-1.10.6-0.30.3-0.30.1-0.1-0.4-0.5-0.1-0.10.71.50.40.00.00.4
Intermitt. access escalation Index0.71.03.2-0.3-0.7-0.9-0.60.8-1.61.6-1.3-1.71.8-0.7-1.2-0.8-0.8-0.1-0.5-0.30.30.1-0.4
Intermittent access day 1 total infusions0.30.41.41.20.70.90.5-0.40.7-0.60.40.4-0.30.30.40.50.3-0.9-0.1-0.8-0.9-0.6-0.4
Intermittent access day 15 total infusions1.52.24.71.62.22.21.9-1.11.7-1.51.21.6-1.60.91.02.00.7-1.7-0.5-1.2-1.4-1.1-1.0
Intermittent access terminal intake (last 3 days)2.33.16.42.12.52.52.3-1.82.3-2.11.92.2-2.21.41.71.71.2-1.4-0.3-1.0-1.0-0.6-0.4
Intermittent access total infusions1.82.15.02.22.12.01.7-1.01.4-1.21.01.4-1.40.70.71.80.5-1.9-0.7-1.7-1.6-1.3-1.1
Intermittent access day 1 locomotion1.01.23.11.81.41.41.3-1.01.4-1.31.01.6-1.60.70.90.40.9-1.2-0.2-1.1-0.6-0.2-0.1
Intermittent access day 15 total locomotion1.73.06.51.82.02.42.1-1.72.6-2.42.02.4-2.41.61.91.11.8-0.90.4-0.6-0.5-0.00.2
Intermittent access total locomotion2.32.85.62.32.02.21.9-1.32.2-2.01.52.3-2.41.11.31.51.3-1.6-0.2-1.5-1.2-0.7-0.5
Intermittent access standard deviation0.10.21.00.30.10.3-0.10.30.6-0.50.20.6-0.8-0.40.20.70.0-0.6-0.0-0.6-1.0-0.7-0.4
Left kidney weight0.41.74.6-1.6-1.6-1.8-1.50.3-0.40.3-0.3-0.40.60.0-0.2-2.10.41.62.11.31.61.71.6
Right kidney weight0.52.15.2-2.1-2.1-2.3-2.11.2-1.31.2-1.2-1.41.5-1.0-1.0-2.2-0.51.01.40.80.91.00.9
Cocaine induced anxiety0.40.61.3-1.1-1.1-1.0-0.51.0-1.01.0-0.7-0.70.8-1.1-0.60.5-0.40.81.00.40.3-0.10.0
Post-drug Anxiety1.71.95.2-1.8-2.3-1.7-1.81.6-1.61.4-1.3-1.41.6-1.3-1.2-0.7-0.71.31.60.80.50.30.5
Baseline Anxiety1.11.32.80.0-1.1-0.9-1.61.3-1.31.3-1.6-1.21.3-0.9-1.7-0.9-1.2-1.1-0.5-1.1-1.0-0.7-0.8
Tail length0.10.41.4-1.2-0.6-1.1-0.90.1-0.50.5-0.4-0.40.4-0.1-0.5-1.2-0.40.5-0.00.60.70.60.4
Length with tail0.10.31.10.91.00.50.3-1.10.5-0.40.50.5-0.50.60.3-0.7-0.1-0.4-0.8-0.40.40.50.1
Length without tail0.51.66.82.61.71.41.3-0.91.1-0.90.71.5-1.50.10.50.8-0.1-1.7-1.2-1.9-0.9-0.6-0.8
Times rat made contact with spout0.10.10.50.1-0.2-0.1-0.3-0.20.3-0.30.20.4-0.40.30.1-0.70.40.20.30.10.40.50.5
Lifetime Intake1.51.85.12.21.91.81.4-0.81.2-1.00.81.2-1.20.50.61.60.3-1.9-0.8-1.7-1.7-1.3-1.1
Liver weight, left0.10.20.9-0.0-0.1-0.4-0.1-0.30.3-0.30.20.3-0.20.20.1-0.90.40.10.8-0.00.50.70.6
Liver weight, right0.30.61.40.40.30.20.2-1.00.6-0.70.90.2-0.11.00.9-1.00.80.90.60.41.01.11.2
Locomotor activity0.30.52.0-0.9-0.8-1.4-1.40.4-0.90.9-0.7-0.20.2-0.7-0.9-0.7-0.70.3-0.20.20.1-0.0-0.1
Locomotor testing distance0.20.31.8-0.7-0.7-0.8-1.40.2-0.20.1-0.00.4-0.3-0.1-0.2-0.20.20.81.10.60.10.10.4
Locomotor testing rearing1.83.76.7-1.3-1.9-1.8-2.42.5-2.52.5-2.5-1.61.6-2.6-2.60.6-2.4-0.9-0.4-1.2-1.7-1.8-1.7
Locomotion in novel chamber0.30.42.3-0.5-0.0-0.70.2-0.5-0.20.10.0-0.60.70.10.2-1.5-0.20.4-0.10.31.31.20.8
Locomotion in novel chamber post-restriction0.81.33.8-0.6-0.8-0.5-0.5-0.30.2-0.40.5-0.40.40.90.7-1.51.01.91.61.71.91.71.7
Fecal boli incidents, locomotor time 10.20.31.3-0.5-0.6-1.0-0.70.1-0.70.6-0.5-0.70.7-0.1-0.5-1.1-0.40.2-0.10.00.40.40.3
Change in fecal boli incidents, locomotor task0.80.72.30.30.1-0.50.30.7-0.60.7-0.7-0.10.1-1.5-0.81.3-1.3-1.1-0.8-1.2-0.9-1.1-1.2
Time >=10cm from walls, locomotor time 12.72.811.0-3.3-2.4-2.5-2.02.0-2.01.9-1.9-1.31.3-1.9-1.8-0.9-1.30.60.60.90.40.2-0.1
Bouts of movement, locomotor time 10.40.51.61.30.90.80.4-0.30.5-0.40.30.8-0.80.10.21.10.2-0.7-0.5-0.7-0.8-0.8-0.7
Total resting periods, locomotor time 10.80.92.81.71.41.20.8-0.80.9-0.80.81.2-1.10.40.51.20.5-0.8-0.5-0.8-0.7-0.7-0.6
Rest time, locomotor task time 12.73.48.62.12.91.72.7-2.82.3-2.22.22.1-2.01.92.00.21.5-0.6-0.6-0.30.80.80.4
Distance moved, locomotor task time 12.53.78.9-2.4-3.0-1.8-2.93.0-2.22.2-2.3-2.01.8-2.2-2.10.5-1.60.70.60.4-1.1-1.2-0.7
Vertical activity count, locomotor time 10.92.15.0-1.4-1.9-0.9-1.92.2-1.91.8-1.8-1.71.5-1.7-1.60.8-1.30.3-0.2-0.0-1.1-1.2-0.9
Time >=10cm from walls, locomotor time 20.91.45.1-2.2-1.6-1.8-1.41.2-1.41.4-1.4-1.00.9-1.3-1.3-1.1-0.90.30.30.30.40.30.1
Bouts of movement, locomotor time 20.20.31.1-0.6-1.1-0.8-0.80.7-0.40.4-0.5-0.10.3-0.5-0.4-0.7-0.10.30.90.20.30.40.4
Total resting periods, locomotor time 20.20.41.4-0.8-1.2-1.0-0.90.7-0.50.4-0.6-0.10.3-0.5-0.4-0.9-0.10.41.00.30.40.50.5
Rest time, locomotor task time 20.40.51.70.71.00.61.3-0.90.9-0.80.70.8-0.60.70.8-0.30.6-0.4-0.4-0.10.60.70.4
Distance moved, locomotor task time 20.80.92.6-1.1-1.3-0.6-1.61.4-1.11.1-1.0-1.10.9-0.8-1.00.5-0.60.40.10.2-0.8-0.9-0.6
Vertical activity count, locomotor time 20.20.20.80.2-0.00.7-0.4-0.30.4-0.50.50.1-0.20.70.5-0.10.90.70.30.50.10.20.4
Light reinforcement 10.10.31.1-0.7-0.9-0.8-1.10.7-0.40.4-0.6-0.30.2-0.3-0.6-0.5-0.30.10.00.0-0.2-0.1-0.0
Light reinforcement 20.60.93.5-0.1-0.1-0.2-0.00.9-1.01.1-1.2-1.41.4-0.8-0.8-0.0-1.0-0.9-1.9-0.7-0.6-0.6-1.0
Bone: marrow area0.10.20.70.90.70.80.5-0.30.1-0.0-0.0-0.10.10.1-0.00.1-0.2-0.8-0.9-0.8-0.4-0.3-0.5
Bone: maximum diameter0.20.42.2-0.8-0.8-1.1-0.70.3-0.50.4-0.6-0.40.5-0.3-0.6-1.5-0.2-0.10.0-0.00.30.50.4
Bone: maximum force0.61.02.81.21.31.71.3-1.21.5-1.41.20.7-0.61.31.30.31.1-0.10.10.10.20.30.3
Bone: maximum moment0.50.92.71.41.41.61.3-1.11.4-1.31.10.6-0.61.11.10.40.9-0.3-0.0-0.2-0.00.10.1
Mean time between licks in bursts0.20.41.30.70.60.50.3-0.70.7-0.60.41.1-1.10.70.2-0.70.4-0.6-0.7-0.60.10.30.1
Mean num. licks in bursts0.20.31.4-0.1-0.40.20.10.30.8-0.80.41.1-1.20.00.40.50.70.20.90.5-0.10.10.3
Cd content in liver1.11.34.8-0.00.10.00.4-0.81.4-1.41.32.2-2.20.70.90.31.20.91.60.90.80.81.1
Co content in liver0.81.02.51.21.31.11.0-1.51.2-1.11.21.6-1.51.10.90.20.7-0.10.1-0.30.30.30.3
Cu content in liver0.70.83.31.61.21.80.9-0.50.8-0.80.50.5-0.50.60.70.80.5-0.8-1.1-0.7-0.7-0.6-0.6
Fe content in liver1.11.33.91.51.62.01.7-1.21.5-1.41.40.8-0.71.01.51.11.1-0.1-0.10.10.0-0.00.0
K content in liver1.51.55.7-1.4-1.3-1.1-1.10.5-0.90.7-0.6-2.02.10.3-0.2-2.40.21.10.71.11.21.31.2
Mg content in liver0.30.31.0-0.7-0.8-0.3-0.50.6-0.50.5-0.5-1.01.0-0.1-0.3-0.7-0.10.30.30.30.10.20.2
Mn content in liver0.10.10.40.2-0.1-0.1-0.60.10.1-0.0-0.1-0.30.3-0.1-0.1-0.1-0.2-0.20.0-0.2-0.5-0.3-0.2
Na content in liver1.21.34.4-1.1-1.1-1.5-1.01.2-1.61.5-1.3-2.12.1-1.1-1.0-0.5-1.00.2-0.30.2-0.2-0.3-0.4
Rb content in liver0.20.20.90.8-0.10.1-0.60.4-0.00.0-0.3-0.30.1-0.3-0.20.3-0.3-0.5-0.7-0.7-0.9-0.7-0.6
Se content in liver1.41.74.01.51.52.01.5-1.31.9-1.81.71.4-1.41.21.71.01.40.10.30.40.00.10.3
Sr content in liver0.90.72.3-1.5-1.2-1.1-0.60.4-0.60.5-0.5-0.60.7-0.0-0.4-1.50.20.71.00.71.01.11.0
Zn content in liver0.80.92.50.2-0.30.50.0-0.41.3-1.30.81.6-1.61.10.8-1.01.30.50.80.60.81.11.1
Bone: minimum diameter0.61.12.41.41.21.61.5-1.11.5-1.51.21.2-1.21.01.00.41.0-0.50.4-0.30.10.20.2
Time in familiar zone, hab. session 10.30.21.50.10.0-0.1-0.4-0.20.5-0.50.41.2-1.20.20.20.70.20.30.60.3-0.0-0.10.1
Time in novel zone, hab. session 10.10.10.4-0.5-0.3-0.10.20.3-0.30.2-0.2-0.60.6-0.20.0-0.40.10.10.10.20.20.20.2
Total zone transitions, hab. session 10.60.92.4-0.7-1.1-1.5-1.01.1-1.11.2-1.20.1-0.1-1.3-1.5-0.2-1.2-0.70.3-0.9-0.5-0.4-0.5
Total locomotion distance, hab. session 10.30.41.1-0.6-0.3-0.6-0.20.6-0.90.9-0.8-0.30.3-1.0-1.00.2-1.0-0.60.0-0.5-0.2-0.4-0.6
Locomotion velocity, hab. session 10.30.41.0-0.8-0.5-0.8-0.30.6-1.01.0-0.9-0.60.6-0.9-0.9-0.2-0.9-0.30.1-0.30.0-0.1-0.4
Time in familiar zone, hab. session 20.10.10.30.00.3-0.10.1-0.50.3-0.30.4-0.00.00.50.3-0.30.30.3-0.20.50.40.40.3
Time in novel zone, hab. session 20.10.10.6-0.4-0.40.2-0.20.40.0-0.0-0.00.3-0.3-0.4-0.00.70.10.20.80.2-0.3-0.3-0.1
Total zone transitions, hab. session 20.60.73.9-1.1-1.3-1.1-1.30.7-0.70.7-0.9-0.40.6-0.2-0.9-2.0-0.2-0.10.2-0.20.30.70.6
Total locomotion distance, hab. session 20.71.02.8-1.5-1.4-1.1-1.60.9-1.11.1-1.1-1.01.1-0.3-1.0-1.7-0.50.20.10.30.30.50.4
Locomotion velocity, hab. session 20.81.02.9-1.4-1.5-1.1-1.51.0-1.21.2-1.3-1.01.2-0.5-1.2-1.7-0.60.0-0.00.10.20.50.3
Novel to familiar place preference ratio0.10.10.30.30.10.20.1-0.1-0.10.10.1-0.40.30.00.10.4-0.10.30.60.10.1-0.1-0.1
Novelty place preference0.20.21.10.20.20.40.4-0.40.4-0.40.5-0.00.00.40.50.30.40.71.10.60.50.30.4
Time in novel zone, NPP test0.20.21.20.40.30.40.5-0.40.5-0.50.60.3-0.30.30.50.70.30.51.10.40.30.10.2
Total zone transitions, NPP test0.60.82.0-1.1-1.0-0.4-0.8-0.00.6-0.70.31.0-1.00.60.3-1.30.90.91.41.00.81.11.3
Total locomotion distance, NPP test0.20.30.5-0.5-0.10.3-0.1-0.40.5-0.50.40.7-0.60.50.3-0.60.50.40.60.60.50.70.7
Locomotion velocity, NPP test0.30.41.4-0.9-0.40.1-0.4-0.30.3-0.40.30.3-0.30.60.3-1.20.60.70.60.90.80.90.9
Intraocular pressure0.20.42.70.20.1-0.2-0.1-0.10.5-0.40.11.7-1.6-0.3-0.30.1-0.4-0.7-0.4-0.4-0.3-0.1-0.2
Delta distance traveled before/after self-admin2.12.210.71.61.10.51.10.6-0.40.5-0.30.2-0.2-1.6-0.53.3-1.3-1.8-0.6-2.0-2.2-2.5-2.2
Delta ambulatory time before/after self-admin1.11.46.61.61.00.60.90.2-0.10.20.00.5-0.5-1.1-0.12.6-0.7-1.3-0.2-1.6-1.7-1.9-1.6
Parametrial fat weight0.00.10.50.2-0.3-0.3-0.30.20.1-0.2-0.20.2-0.2-0.00.0-0.70.3-0.3-0.3-0.1-0.20.10.2
Pavlov. Cond. lever latency0.50.61.2-0.20.30.50.6-0.80.7-0.80.80.4-0.41.00.9-0.81.00.80.31.11.11.10.9
Pavlov. Cond. magazine entry latency0.30.42.0-0.7-0.7-0.8-1.40.3-0.70.6-0.3-0.80.8-0.0-0.4-0.3-0.30.91.00.40.20.00.3
Pavlov. Cond. change in total contacts0.40.41.9-0.0-0.1-0.1-0.50.4-0.90.9-0.5-1.31.4-0.6-0.40.5-0.70.1-0.1-0.4-0.4-0.7-0.5
Pavlov. Cond. index score0.20.20.50.1-0.2-0.3-0.70.3-0.60.6-0.4-0.50.5-0.4-0.50.5-0.6-0.10.2-0.6-0.6-0.7-0.5
Pavlov. Cond. latency score0.10.20.6-0.1-0.4-0.5-0.80.4-0.50.5-0.3-0.30.3-0.4-0.50.4-0.50.00.5-0.4-0.5-0.5-0.3
Pavlov. Cond. lever contacts0.20.30.70.3-0.1-0.0-0.30.4-0.50.5-0.4-0.30.4-0.6-0.50.8-0.6-0.4-0.1-0.8-0.8-0.8-0.6
Pavlov. Cond. magazine entry number0.20.31.40.40.50.51.2-0.30.7-0.60.30.9-0.80.30.4-0.20.4-0.7-0.7-0.20.10.30.1
Pavlov. Cond. intertrial magazine entries0.50.51.81.10.20.50.30.6-0.10.2-0.5-0.20.2-0.6-0.40.8-0.5-1.3-0.4-1.4-1.2-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.0-0.2-0.3-0.80.4-0.70.7-0.5-0.80.8-0.5-0.60.4-0.7-0.10.1-0.5-0.6-0.7-0.5
Pavlov. Cond. response bias0.30.41.3-0.5-0.5-0.5-1.10.4-0.90.9-0.5-1.21.1-0.4-0.50.2-0.60.60.50.1-0.2-0.4-0.2
Pavlov. Cond. lever latency0.00.00.10.20.00.30.20.2-0.10.00.0-0.30.3-0.30.30.4-0.00.2-0.30.2-0.1-0.2-0.1
Pavlov. Cond. magazine entry latency0.20.30.9-0.9-0.6-0.7-0.40.10.2-0.2-0.00.6-0.50.1-0.1-0.70.30.41.00.50.70.80.7
Pavlov. Cond. change in total contacts0.40.62.9-1.2-1.0-0.9-1.10.10.1-0.20.10.3-0.20.4-0.1-1.00.60.91.70.80.70.91.0
Pavlov. Cond. index score0.10.21.1-0.6-0.5-0.5-0.4-0.00.3-0.30.10.6-0.50.3-0.2-0.30.30.31.10.20.40.50.5
Pavlov. Cond. latency score0.30.41.6-0.9-0.6-0.5-0.4-0.10.4-0.40.20.6-0.40.50.0-0.70.60.51.30.60.80.90.9
Pavlov. Cond. lever contacts0.00.10.3-0.2-0.1-0.4-0.3-0.10.1-0.10.00.5-0.40.2-0.3-0.20.0-0.10.6-0.20.10.20.1
Pavlov. Cond. magazine entry number0.60.83.01.51.10.81.0-0.3-0.30.3-0.1-0.40.3-0.3-0.00.9-0.7-1.0-1.7-1.1-0.9-1.0-1.1
Pavlov. Cond. intertrial magazine entries0.30.51.3-0.3-0.5-0.3-0.41.0-0.80.8-0.8-0.60.5-0.9-0.60.4-0.8-0.5-1.1-0.3-0.9-0.9-0.8
Pavlov. Cond. lever-magazine prob. diff.0.20.21.3-0.7-0.6-0.5-0.50.10.2-0.20.00.5-0.40.2-0.2-0.30.30.31.10.30.40.50.5
Pavlov. Cond. response bias0.10.10.4-0.2-0.1-0.3-0.5-0.10.2-0.20.10.6-0.60.2-0.3-0.10.1-0.10.5-0.1-0.00.10.1
Time in closed arm before self-admin0.10.10.70.00.20.00.40.2-0.20.3-0.3-0.60.8-0.6-0.10.4-0.1-0.3-0.1-0.4-0.1-0.2-0.3
Time in closed arm after self-admin1.31.43.4-0.20.71.10.9-1.31.3-1.41.50.5-0.31.71.5-0.21.81.21.01.41.11.01.2
Time in open arm before self-admin0.70.82.71.41.00.90.1-0.91.0-0.90.91.5-1.60.90.60.60.4-0.4-0.4-0.4-0.7-0.4-0.2
Time in open arm after self-admin0.30.31.50.90.3-0.20.1-0.0-0.50.5-0.4-0.30.1-0.3-0.5-0.3-0.9-0.8-1.2-1.0-0.3-0.2-0.5
Bone: periosteal estimation0.00.10.20.40.40.40.3-0.30.2-0.10.1-0.10.20.20.0-0.20.0-0.5-0.3-0.4-0.1-0.0-0.1
Bone: periosteal perimeter0.40.61.5-0.7-1.0-1.1-0.91.0-0.90.9-1.1-0.60.6-0.9-1.2-0.6-0.8-0.6-0.1-0.6-0.4-0.2-0.3
Bone: post-yield work0.10.10.40.20.30.20.0-0.50.5-0.50.40.2-0.30.40.2-0.60.3-0.20.1-0.10.10.30.3
Progressive ratio test 1 active lever presses0.91.13.80.90.40.60.00.8-0.50.6-0.7-0.10.1-0.8-0.81.4-0.7-1.7-0.7-1.7-2.0-1.7-1.6
Progressive ratio test 1 breakpoint0.81.03.61.00.40.70.10.6-0.40.5-0.6-0.00.1-0.6-0.71.3-0.6-1.7-0.7-1.6-1.9-1.6-1.5
Progressive ratio test 1 inactive lever presses0.00.10.30.2-0.00.6-0.20.3-0.10.1-0.2-0.20.2-0.2-0.10.20.2-0.30.2-0.2-0.5-0.4-0.3
Progressive ratio test 2 active lever presses1.61.96.72.62.02.01.7-0.91.1-1.00.81.1-1.00.60.71.60.4-1.8-0.8-1.6-1.3-1.1-1.0
Progressive ratio test 2 breakpoint1.72.07.42.72.12.11.7-1.01.2-1.10.91.2-1.00.70.71.50.5-1.8-0.9-1.6-1.3-1.0-1.0
Progressive ratio test 2 inactive lever presses0.50.71.71.21.21.31.1-0.61.0-0.90.60.9-0.80.30.60.80.6-1.20.0-1.0-0.8-0.5-0.5
Incentive Sensitization - Responses1.31.96.22.52.11.91.9-1.51.6-1.51.31.4-1.30.91.11.00.7-1.2-0.6-1.2-0.5-0.3-0.3
Incentive Sensitization - Breakpoint1.62.16.52.52.21.92.1-1.71.8-1.61.51.5-1.41.01.31.00.9-1.2-0.5-1.1-0.4-0.2-0.3
Sum of active levers in priming session hrs 5-60.30.31.21.10.80.80.4-0.60.6-0.60.50.3-0.30.60.4-0.00.1-0.6-0.7-0.8-0.4-0.2-0.1
Progressive ratio0.20.31.20.50.60.11.0-0.80.5-0.50.40.4-0.40.30.4-1.10.2-0.5-0.4-0.70.60.80.5
Food seeking constrained by brief footshock1.21.44.31.61.91.61.3-0.80.8-0.60.41.1-1.00.30.20.7-0.0-2.1-1.8-1.7-1.1-0.8-1.1
Seeking ratio, punishment vs. effort0.30.42.30.40.51.10.10.00.5-0.40.30.6-0.60.10.31.50.4-0.2-0.00.1-0.8-0.9-0.7
Retroperitoneal fat weight0.00.00.2-0.10.10.10.20.30.00.0-0.2-0.20.3-0.1-0.00.20.1-0.5-0.2-0.1-0.4-0.2-0.3
Reaction time number correct0.20.41.61.31.01.00.8-0.40.4-0.30.30.2-0.20.10.30.40.1-0.7-0.7-0.8-0.5-0.5-0.5
Reaction time mean minus median0.20.51.4-0.7-0.8-0.3-0.51.2-0.70.7-0.7-0.70.6-0.9-0.61.2-0.70.10.30.2-0.6-0.8-0.6
Reaction time mean minus median AUC0.10.42.0-0.5-0.60.1-0.51.0-0.40.4-0.5-0.50.4-0.6-0.41.4-0.50.20.30.3-0.7-0.9-0.7
Reaction time num false alarms2.23.15.40.21.31.31.5-2.32.1-2.12.31.7-1.62.12.2-0.92.21.41.11.62.02.01.9
Reaction time num false alarms AUC1.82.74.7-0.01.01.01.1-2.21.9-1.92.11.5-1.52.02.0-1.02.01.51.11.72.01.91.9
Reaction time trials correct on left0.20.41.61.31.01.00.8-0.40.4-0.30.30.2-0.20.10.30.40.1-0.7-0.7-0.8-0.5-0.5-0.5
Reaction time trials on left0.20.31.41.20.91.00.7-0.40.3-0.30.30.1-0.10.00.30.40.0-0.7-0.6-0.8-0.4-0.4-0.5
Reaction time mean1.11.85.1-1.2-1.7-1.3-1.22.3-1.41.5-1.7-1.10.9-2.0-1.51.2-1.7-0.3-0.2-0.2-1.2-1.3-1.1
Reaction time mean AUC1.01.64.4-0.9-1.5-1.0-1.22.1-1.31.3-1.5-1.00.8-1.7-1.41.4-1.5-0.3-0.4-0.2-1.3-1.4-1.2
Median of all reaction times1.21.74.8-1.0-1.6-1.2-1.22.2-1.41.4-1.6-0.90.8-2.0-1.51.2-1.7-0.5-0.4-0.4-1.2-1.3-1.1
Reaction time omissions0.91.34.9-2.2-1.9-1.3-1.61.1-0.80.7-0.7-0.80.7-0.4-0.5-0.8-0.31.51.11.60.70.60.8
Reaction time false alarm rate1.52.14.0-1.00.20.20.4-1.51.3-1.41.51.1-1.11.61.5-1.11.71.81.52.02.01.92.0
Reaction time premature initiation rate0.50.73.2-1.5-1.6-1.4-0.50.9-0.10.1-0.40.1-0.1-0.7-0.4-0.70.10.51.80.50.50.60.8
Reaction time premature initiations0.20.41.5-1.0-1.2-1.1-0.40.9-0.30.3-0.6-0.20.2-0.9-0.5-0.5-0.20.11.10.00.20.30.4
Std. dev. reaction times0.50.83.1-1.8-1.6-0.9-1.11.4-0.60.5-0.6-0.40.3-0.9-0.40.7-0.41.11.31.30.0-0.10.2
Reaction time trials completed0.20.31.41.20.91.00.7-0.40.3-0.30.30.1-0.10.00.30.40.0-0.7-0.6-0.8-0.4-0.4-0.5
Reaction time trials AUC0.20.31.41.20.91.00.8-0.50.4-0.40.40.2-0.20.20.40.40.2-0.6-0.5-0.7-0.4-0.3-0.4
Run reversals in cocaine runway, females1.21.24.7-2.2-1.2-1.5-1.20.5-1.10.9-0.8-1.21.2-0.5-0.6-1.8-0.40.90.30.81.01.00.8
Run reversals in cocaine runway, males1.11.12.9-1.3-0.6-0.2-0.6-0.40.5-0.60.5-0.10.21.40.6-1.61.51.41.01.71.31.41.4
Latency to leave start box in cocaine runway2.02.35.3-1.9-2.3-2.1-2.02.0-1.91.8-1.8-1.81.7-1.5-1.5-0.8-1.30.60.60.2-0.0-0.1-0.0
Latency to leave start box in cocaine runway, F0.70.82.9-0.9-1.7-1.5-1.21.2-0.90.9-0.8-0.70.7-0.9-0.7-0.3-0.70.81.00.40.20.10.4
Latency to leave start box in cocaine runway, M2.92.75.5-1.6-1.3-1.4-1.52.0-2.32.3-2.2-2.32.2-1.8-1.9-0.2-1.7-0.6-0.8-0.7-0.9-1.0-1.3
Std. dev. time between licks in bursts1.21.73.5-0.5-0.1-0.0-0.1-1.01.5-1.51.21.8-1.91.51.1-1.11.81.21.61.21.21.51.6
Total sessions with >9 infusions0.81.03.71.20.00.2-0.20.9-0.30.4-0.7-0.10.1-0.9-0.70.9-1.0-1.7-0.6-1.7-1.9-1.5-1.3
Short access day 1 total inactive lever presses1.82.45.0-0.6-1.4-1.2-1.52.0-2.02.0-2.2-1.71.7-1.8-2.1-0.6-1.9-1.3-0.7-1.4-1.3-1.0-1.2
Short access day 10 total inactive lever presses0.71.64.7-2.0-2.1-1.6-1.81.0-0.60.4-0.5-0.70.5-0.5-0.3-1.60.41.62.21.20.80.91.3
Short access day 1 total infusions0.81.13.21.3-0.20.0-0.51.1-0.70.8-1.0-1.01.0-1.0-0.90.6-1.0-1.5-0.6-1.6-1.8-1.4-1.3
Short access day 10 total infusions0.91.22.31.31.31.41.5-0.81.5-1.31.11.4-1.40.51.01.30.9-0.90.4-0.7-0.7-0.5-0.2
Short access total infusions0.60.72.81.40.50.80.30.50.2-0.1-0.30.1-0.1-0.4-0.21.1-0.3-1.5-0.4-1.4-1.7-1.3-1.1
Short access day 1 locomotion1.21.53.51.91.61.71.2-0.81.3-1.20.81.4-1.40.70.81.00.4-1.7-1.0-1.4-1.4-0.9-0.7
Short access day 10 total locomotion0.20.31.5-0.0-0.4-0.0-0.10.40.6-0.60.21.1-1.2-0.10.20.30.7-0.31.0-0.4-0.6-0.20.2
Short access total locomotion0.91.14.70.5-0.20.1-0.21.2-0.10.2-0.80.5-0.6-1.0-0.81.3-0.6-1.8-0.5-1.7-2.2-1.7-1.4
One hour access (0.3 mA shock)2.63.07.72.42.62.72.3-1.21.7-1.61.41.5-1.41.01.32.80.8-1.6-1.0-1.2-1.5-1.4-1.2
Compulsive drug intake1.01.22.8-1.7-1.4-1.3-0.61.6-1.41.3-1.1-1.01.0-1.6-0.81.2-0.80.81.10.50.0-0.4-0.3
One hour access (shock baseline)2.23.38.62.92.92.92.0-1.82.0-1.81.61.4-1.41.71.31.70.9-1.8-1.5-1.4-1.4-1.1-1.0
Social response proportion2.42.75.1-1.9-2.0-2.2-1.72.0-2.22.2-2.2-1.91.9-1.5-2.2-1.0-1.8-0.5-0.7-0.6-0.6-0.5-0.6
Social responses0.81.03.2-1.8-1.6-1.5-1.50.7-0.60.5-0.4-0.50.5-0.1-0.4-1.0-0.01.31.31.10.70.71.0
Social time0.30.41.7-0.8-1.3-1.0-0.60.8-0.10.1-0.50.4-0.3-0.5-0.4-1.10.10.10.40.10.40.70.7
Soleus weight0.72.04.62.02.21.92.2-1.61.6-1.51.51.8-1.80.81.41.40.7-0.7-0.6-0.5-0.1-0.1-0.3
Bone: stiffness0.71.13.10.81.21.81.0-1.41.3-1.41.30.5-0.51.71.4-0.41.40.3-0.10.60.60.70.6
Tibialis anterior weight0.72.57.71.60.90.50.90.8-0.81.0-1.2-0.50.5-1.4-1.21.3-1.7-2.8-2.4-2.7-2.0-1.8-2.2
Time to tail flick, vehicle, before self-admin0.91.02.6-1.1-1.6-1.2-1.31.6-1.11.1-1.4-0.80.9-1.3-1.2-0.4-0.7-0.10.4-0.0-0.3-0.2-0.3
Time to tail flick, vehicle, after self-admin1.21.63.20.50.80.80.6-1.81.4-1.51.50.7-0.61.81.5-1.51.61.00.50.91.61.71.6
Time to tail flick, test, before self-admin0.20.31.00.40.61.00.3-0.50.6-0.60.60.4-0.30.80.50.70.4-0.0-0.00.1-0.5-0.3-0.1
Time to tail flick, test, after self-admin0.40.42.3-0.40.10.4-0.1-0.2-0.30.2-0.0-1.51.51.00.2-0.60.50.70.30.90.40.30.2
Delta time to tail flick, vehicle, before/after SA0.60.51.2-0.00.20.1-0.0-0.90.5-0.60.8-0.00.01.00.8-0.90.81.10.60.91.01.01.1
Delta time to tail flick, test, before/after SA0.70.83.2-0.6-0.6-0.9-0.70.7-1.31.2-1.0-1.81.7-0.5-0.8-0.9-0.70.3-0.40.20.40.2-0.2
Tibia length0.30.93.1-0.9-1.4-1.2-1.71.4-0.90.9-1.2-0.60.6-1.3-1.1-0.4-0.7-0.20.0-0.3-0.7-0.5-0.3
Ambulatory time before self-admin0.30.52.1-1.4-1.2-0.8-0.90.4-0.10.0-0.3-0.1-0.00.3-0.2-1.20.20.70.20.80.60.80.8
Ambulatory time after self-admin0.20.21.20.1-0.2-0.10.20.6-0.10.1-0.20.3-0.3-0.6-0.21.1-0.3-0.50.1-0.5-0.8-0.8-0.6
Bone: tissue strength0.70.71.80.4-0.1-0.6-0.90.6-1.01.0-1.0-1.01.0-0.5-1.0-0.3-1.1-0.9-1.3-1.0-0.9-0.8-1.0
Total heroin consumption0.20.31.60.60.50.10.4-0.3-0.10.1-0.1-0.70.8-0.00.0-0.8-0.3-0.6-1.3-0.60.10.2-0.1
Bone: trabecular number0.91.54.30.5-0.1-0.2-1.31.0-1.21.3-1.4-0.90.8-0.7-1.40.1-1.5-1.3-2.1-1.4-1.5-1.4-1.6
Bone: trabecular spacing0.20.20.8-0.00.30.00.9-0.50.6-0.60.60.8-0.80.00.60.30.30.20.20.30.50.30.4
Bone: trabecular thickness1.11.33.81.50.70.5-0.30.4-0.70.8-0.9-0.70.7-0.5-1.00.5-1.2-1.7-2.0-1.9-1.6-1.4-1.6
Bone: trabecular tissue density2.53.68.5-0.8-1.9-2.1-1.62.7-2.12.2-2.5-1.51.5-2.9-2.40.8-2.1-1.4-0.7-1.5-1.9-1.9-1.7
Water consumed over 24 hours0.10.10.20.40.30.30.3-0.40.4-0.40.30.1-0.10.30.4-0.50.40.10.00.10.40.50.4
Number of responses in last shaping day2.42.710.13.22.12.61.4-1.32.0-1.91.51.7-1.71.41.41.31.2-1.4-0.6-1.2-1.3-0.8-0.5