Hub : Genes

Hpse

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Hpse 0.19 0.11 2.2e-03 0.08 0.08 0.04 0.09 5.5e-03 5.0e-03 3.3e-02 4.8e-03
2 BLA gene expression Hpse 0.25 0.11 2.1e-08 0.07 0.14 0.12 0.12 1.4e-04 8.5e-08 5.1e-07 4.4e-07
3 pVTA gene expression Hpse 0.11 0.06 3.2e-04 0.01 0.04 0.02 0.02 4.9e-02 5.7e-04 9.0e-03 6.2e-03
4 Eye gene expression Hpse 0.4 0.16 1.0e-03 0.2 0.11 0.04 0.14 6.1e-04 8.4e-03 7.3e-02 3.4e-03
5 PL gene expression Hpse 0.04 0.03 6.7e-04 0 0.02 0.01 0.01 1.7e-01 3.1e-03 1.5e-02 2.9e-02
6 Liver gene expression Hpse 0.18 0.07 1.1e-14 0.11 0.11 0.1 0.11 3.0e-12 3.4e-12 1.7e-11 4.0e-12
7 Brain gene expression Hpse 0.05 0.03 9.2e-04 0.01 0.03 0.02 0.02 1.8e-02 4.2e-04 3.1e-03 3.0e-03
8 Liver mRNA stability Hpse 0.05 0.03 2.2e-04 0.01 0.03 0.02 0.02 5.3e-02 4.4e-04 6.4e-03 6.7e-03
9 Adipose mRNA stability Hpse 0.19 0.09 0.0e+00 0.13 0.13 0.18 0.13 1.9e-14 4.2e-14 1.8e-19 3.7e-14
10 Adipose gene expression Hpse 0.31 0.13 0.0e+00 0.18 0.23 0.23 0.23 1.2e-19 7.0e-25 9.4e-26 1.8e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.23.98.42.02.91.92.01.4-2.2-0.4-2.6-2.11.0
Area under the delay curve1.11.33.80.5-0.20.50.70.52.01.91.1-1.40.9
BMI with tail0.41.52.91.71.31.31.30.90.61.3-0.2-1.31.4
BMI without tail0.82.34.52.12.01.81.71.2-0.21.0-0.8-1.71.6
Body weight0.83.47.62.42.12.81.81.90.32.0-0.8-1.01.7
Weight adjusted by age1.11.73.71.91.51.70.81.90.51.4-1.10.1-0.7
Bone surface1.52.76.32.12.51.32.11.1-1.00.0-1.6-2.01.3
Bone volume2.24.08.71.93.02.01.91.6-2.4-0.6-2.9-1.60.4
Breakpoint value in progressive ratio session0.10.20.80.00.10.60.10.30.20.6-0.0-0.90.2
Number of licking bursts0.20.30.6-0.8-0.7-0.7-0.8-0.6-0.1-0.40.40.5-0.7
Context. condit. distance diff. score0.91.12.50.71.41.30.21.6-0.20.6-1.40.3-1.2
Locomotion velocity, session 10.91.02.41.51.30.61.51.00.60.7-0.5-1.00.2
Locomotion distance, session 12.53.26.02.41.81.72.32.01.62.2-0.5-1.60.9
Locomotion velocity, session 20.30.31.10.5-0.2-0.30.3-0.31.00.60.9-0.10.5
Locomotion distance, session 21.82.54.72.01.31.22.21.31.61.90.1-1.81.5
Locomotion velocity, session 30.30.31.40.00.0-0.0-0.30.40.90.5-0.00.8-1.2
Locomotion distance, session 30.40.40.90.90.70.50.40.70.90.8-0.2-0.4-0.2
Stereotopy head waving bouts, day 31.21.44.40.01.50.30.30.9-1.3-0.9-2.10.3-2.1
Stereotopy head waving duration, day 31.41.75.3-0.51.20.5-0.20.9-1.7-1.0-2.20.7-2.3
Locomotion velocity, session 71.31.43.00.91.61.61.01.6-0.60.5-1.7-0.8-0.6
Locomotion distance, session 71.31.63.21.30.10.21.40.31.81.51.0-1.61.7
Stereotopy head waving bouts, day 71.21.44.1-0.70.70.3-1.00.6-1.0-0.8-1.61.8-2.0
Stereotopy head waving duration, day 71.61.94.6-0.80.60.6-1.20.7-1.7-1.1-1.91.9-2.1
Locomotion velocity, session 80.91.12.50.41.21.30.11.4-0.60.3-1.50.7-1.6
Locomotion distance, session 80.71.02.41.01.21.10.61.50.91.3-0.70.0-0.9
Degree of sensitization distance1.01.13.1-0.1-1.2-0.80.4-0.71.20.71.8-0.51.7
Degree of sensitization stereotypy0.80.93.0-0.80.30.2-1.10.3-0.6-0.6-0.91.7-1.5
Conditioned locomotion1.01.13.00.70.91.7-0.01.7-0.30.8-1.50.6-0.9
Cocaine response after cond. corrected0.70.92.0-1.4-1.3-1.0-1.0-1.2-0.3-0.90.60.6-0.2
Cocaine response after cond. not corrected0.60.71.6-1.3-1.2-0.8-0.9-1.0-0.2-0.70.60.7-0.0
Cocaine response before conditioning0.10.10.20.50.4-0.20.40.00.30.10.1-0.10.5
Saline control response0.40.52.10.90.9-0.10.70.71.40.7-0.1-0.3-0.3
Bone: connectivity density2.13.47.41.82.71.62.01.2-1.8-0.3-2.2-2.41.1
Bone: cortical apparent density0.20.20.8-0.6-0.3-0.1-0.50.1-0.1-0.2-0.40.7-0.9
Bone: cortical area0.91.33.11.31.71.21.11.2-0.40.2-1.5-1.30.4
Bone: cortical porosity0.20.20.80.80.1-0.10.3-0.40.20.00.3-0.60.9
Bone: cortical porosity0.30.41.20.90.3-0.20.6-0.4-0.1-0.30.1-1.11.0
Bone: cortical thickness0.30.51.70.81.10.40.60.5-0.1-0.0-0.9-1.30.1
Bone: cortical thickness1.51.86.61.31.9-0.21.8-0.1-0.4-0.6-0.8-2.61.2
Bone: cortical tissue density0.20.30.8-0.8-0.5-0.3-0.7-0.1-0.1-0.3-0.20.9-0.9
Condit. Reinf. active minus inactive responses0.60.62.1-0.50.50.9-0.10.9-1.0-0.2-1.40.2-1.0
Condit. Reinf. active-inactive response ratio0.91.02.7-0.70.61.3-0.30.9-1.6-0.4-1.60.4-0.9
Condit. Reinf. active responses0.60.71.50.91.01.01.11.20.40.8-0.8-0.50.2
Condit. Reinf. inactive responses1.31.63.41.91.20.51.81.21.51.4-0.1-1.00.8
Incentive salience index mean0.30.31.0-0.10.40.70.11.00.10.4-0.90.2-0.8
Condit. Reinf. lever presses1.01.33.21.40.71.01.11.51.71.8-0.2-0.60.1
Condit. Reinf. active minus inactive responses0.40.51.50.5-0.4-0.60.5-0.41.20.51.1-0.51.0
Condit. Reinf. active-inactive response ratio1.01.23.60.3-1.1-0.70.4-0.91.30.61.9-0.61.8
Condit. Reinf. active responses0.50.72.70.3-0.6-1.10.1-0.71.70.41.4-0.10.6
Condit. Reinf. inactive responses0.20.31.4-0.30.3-0.4-0.40.10.3-0.2-0.40.6-1.2
Condit. Reinf. lever presses0.40.61.3-0.7-0.9-1.2-0.7-0.70.6-0.50.60.8-0.8
Condit. Reinf. lever reinforcers received0.40.61.6-0.1-0.6-1.3-0.2-0.91.2-0.11.20.10.3
Conditioned reinforcement - actives0.30.41.6-0.5-0.3-1.3-0.4-0.9-0.3-1.20.10.2-0.3
Conditioned reinforcement - inactives0.10.10.30.20.3-0.10.40.20.50.30.0-0.0-0.1
Conditioned locomotion0.70.92.3-1.5-1.1-0.5-1.3-0.4-0.0-0.30.51.5-0.9
Patch foraging indifference point 0 sec0.30.62.80.80.4-0.00.60.51.71.10.6-0.30.4
Patch foraging indifference point AUC0.40.51.1-0.5-0.20.7-0.70.6-1.0-0.2-0.80.9-1.0
Delay disc. indifference point, 0s delay1.71.94.61.91.20.21.70.51.61.20.3-2.21.2
Delay disc. indifference point, 16s delay0.10.10.3-0.5-0.40.2-0.20.30.20.40.0-0.2-0.6
Delay disc. indifference point, 2s delay0.50.51.70.50.10.40.30.31.31.30.7-0.90.5
Delay disc. indifference point, 24s delay1.61.84.4-1.8-2.1-0.8-2.0-0.90.70.01.31.3-0.8
Delay disc. indifference point, 4s delay3.03.15.72.11.41.02.21.32.12.30.2-2.41.5
Delay disc. indifference point, 8s delay0.60.61.9-0.1-0.50.40.20.11.31.41.1-0.80.8
Indifference point function ln k0.81.33.00.70.1-1.50.7-1.11.70.21.6-0.71.6
Indifference point function log k0.81.33.00.70.1-1.50.7-1.11.70.21.6-0.71.6
Patch foraging total patch changes 0 sec0.61.14.41.10.50.00.90.62.11.50.8-0.60.7
Patch foraging total patch changes 12 sec0.10.10.3-0.2-0.2-0.30.1-0.30.1-0.00.4-0.50.2
Patch foraging total patch changes 18 sec0.81.22.31.21.11.21.41.4-0.00.9-0.9-1.5-0.0
Patch foraging total patch changes 24 sec1.22.04.91.31.52.21.41.8-0.61.2-1.3-1.50.6
Patch foraging total patch changes 6 sec0.30.51.30.50.51.00.51.00.61.1-0.2-0.80.3
Patch foraging time to switch 0 sec0.10.20.9-0.7-0.20.1-0.1-0.4-1.0-0.5-0.3-0.6-0.0
Patch foraging water rate 0 sec0.20.41.5-0.1-0.2-0.0-0.60.50.90.60.21.2-0.9
Patch foraging water rate 12 sec1.94.18.22.42.92.32.22.7-0.11.3-2.2-1.80.2
Patch foraging water rate 18 sec1.42.13.92.01.31.51.41.61.42.0-0.2-1.11.2
Patch foraging water rate 24 sec1.72.44.61.92.12.01.52.10.11.4-1.4-0.90.5
Patch foraging water rate 6 sec0.50.71.90.91.40.60.71.30.10.3-1.3-0.3-0.7
Seeking ratio, delayed vs. immediate footshock0.91.12.31.31.31.50.81.40.21.2-0.7-0.90.5
Distance traveled before self-admin0.20.20.80.30.80.20.70.3-0.20.0-0.3-0.90.4
Distance traveled after self-admin1.11.43.51.61.90.91.21.4-0.20.5-1.3-1.10.1
Extensor digitorum longus weight3.413.627.25.24.34.04.44.11.93.9-1.6-3.22.4
Bone: elastic displacement0.91.02.31.50.80.51.20.70.91.10.1-1.31.1
Bone: elastic work0.91.23.61.51.20.61.40.70.00.4-0.6-1.91.2
Bone: endosteal estimation0.20.51.10.70.81.00.40.8-0.60.3-0.8-0.50.6
Bone: endosteal perimeter0.81.74.51.11.62.11.11.9-0.51.0-1.5-0.40.2
Epididymis fat weight0.10.31.7-0.20.30.4-0.1-0.3-1.3-0.5-0.30.20.4
Delta time in closed arm before/after self-admin3.12.85.52.11.41.22.31.31.11.7-0.1-2.32.0
Delta time in open arm before/after self-admin5.95.910.2-3.2-2.6-2.5-2.9-3.0-1.8-2.91.12.0-1.2
Diff in mean of infusions in LGA sessions1.01.22.5-1.3-1.6-0.4-1.6-0.50.60.20.91.6-1.1
Delay discount exponential model param1.21.34.4-0.30.4-0.4-0.5-0.4-2.1-2.0-1.31.2-0.9
Extinction: sum of active levers before priming1.01.12.9-0.9-0.31.2-1.21.0-0.90.3-0.91.4-1.7
Active lever presses in extinction session 60.40.41.20.5-0.21.00.20.6-0.80.3-0.3-1.10.9
Bone: final force0.91.44.01.41.40.81.40.5-0.40.2-0.7-2.01.6
Bone: final moment1.11.84.71.61.50.81.60.5-0.30.3-0.5-2.22.1
Food consumed during 24 hour testing period0.50.72.5-1.0-0.4-1.1-0.7-0.6-0.1-0.9-0.10.5-1.6
Glucose0.40.61.4-0.5-0.70.2-0.30.11.11.21.11.0-0.1
Heart weight0.40.71.60.81.00.41.20.0-0.8-0.2-0.3-1.01.3
Delay discount hyperbolic model param1.41.64.8-0.60.2-0.5-0.7-0.5-2.2-2.1-1.31.4-1.1
Intermittent access intake day 1-15 change0.30.51.10.80.91.00.11.0-0.10.4-1.1-0.2-0.5
Intermittent access intake escalation0.30.61.40.70.81.2-0.01.1-0.20.5-1.1-0.2-0.6
Intermittent access intake escalation 20.91.03.21.20.21.60.11.31.01.80.10.20.4
Intermitt. access day 1 inactive lever presses0.93.67.42.02.12.72.42.6-0.02.0-1.3-1.01.0
Intermitt. access day 15 inactive lever presses1.02.17.70.51.12.80.32.2-0.91.3-1.71.0-0.8
Intermitt. access escalation Index0.10.20.8-0.9-0.3-0.2-0.7-0.5-0.2-0.40.0-0.0-0.5
Intermittent access day 1 total infusions0.20.41.3-1.1-0.9-0.5-0.5-0.7-0.4-0.50.50.30.1
Intermittent access day 15 total infusions0.30.41.0-0.30.21.0-0.50.5-1.0-0.1-1.00.0-0.7
Intermittent access terminal intake (last 3 days)0.50.71.6-0.40.41.1-0.60.8-1.1-0.1-1.30.5-1.1
Intermittent access total infusions0.30.41.0-0.9-0.30.2-0.8-0.1-1.0-0.6-0.50.4-0.5
Intermittent access day 1 locomotion0.30.30.9-1.0-0.6-0.2-0.6-0.3-0.7-0.50.00.9-0.3
Intermittent access day 15 total locomotion0.61.12.0-1.2-0.6-0.6-1.3-0.8-1.4-1.4-0.51.2-1.2
Intermittent access total locomotion1.51.83.7-1.9-0.9-0.3-1.8-0.5-1.4-1.2-0.51.9-1.6
Intermittent access standard deviation0.61.22.31.31.41.50.91.3-0.00.9-1.1-1.10.1
Left kidney weight0.73.25.02.21.72.22.21.80.51.9-0.5-1.81.9
Right kidney weight1.04.47.82.81.92.22.51.91.62.70.2-1.42.3
Cocaine induced anxiety1.01.44.3-0.1-1.2-1.3-0.3-1.02.00.72.11.20.3
Post-drug Anxiety0.10.20.70.10.1-0.60.2-0.30.4-0.10.30.9-0.2
Baseline Anxiety2.42.88.6-0.81.20.0-0.30.2-2.9-2.5-2.8-0.0-1.9
Tail length0.31.13.20.20.91.2-0.30.9-1.8-0.5-1.70.7-0.9
Length with tail0.31.13.01.11.31.70.51.5-0.50.7-1.20.7-0.3
Length without tail0.31.13.21.20.51.00.71.11.61.80.40.50.4
Times rat made contact with spout0.80.94.00.2-0.4-1.2-0.0-0.62.00.61.50.40.2
Lifetime Intake0.40.51.4-1.0-0.30.3-0.8-0.1-1.2-0.6-0.60.6-0.7
Liver weight, left0.61.14.0-0.1-0.61.3-0.41.21.32.00.60.9-0.0
Liver weight, right0.71.35.3-0.80.3-0.1-0.90.6-1.0-0.9-1.41.4-2.3
Locomotor activity0.40.61.91.41.0-0.41.10.20.80.1-0.2-1.00.5
Locomotor testing distance1.52.66.82.62.10.42.31.31.21.0-0.8-2.10.8
Locomotor testing rearing1.12.25.22.01.1-0.61.7-0.11.80.70.7-2.32.0
Locomotion in novel chamber0.91.12.80.60.20.90.70.51.41.70.8-1.21.5
Locomotion in novel chamber post-restriction0.60.92.9-0.3-0.8-0.90.1-1.01.20.31.7-0.21.5
Fecal boli incidents, locomotor time 10.40.63.20.10.20.21.0-0.20.00.20.3-1.81.1
Change in fecal boli incidents, locomotor task0.60.63.10.80.3-0.40.30.41.81.00.61.0-0.0
Time >=10cm from walls, locomotor time 11.51.64.60.70.62.11.02.00.42.0-0.6-1.00.0
Bouts of movement, locomotor time 11.71.95.1-0.6-2.1-1.3-1.3-1.90.9-0.22.20.70.8
Total resting periods, locomotor time 11.61.84.6-0.5-2.1-1.4-1.3-1.81.0-0.22.20.90.5
Rest time, locomotor task time 10.20.30.80.9-0.5-0.30.1-0.40.70.30.70.30.2
Distance moved, locomotor task time 10.20.41.20.01.10.20.70.3-0.5-0.2-0.6-0.70.7
Vertical activity count, locomotor time 10.41.02.8-0.11.60.21.20.7-0.8-0.4-1.3-1.70.2
Time >=10cm from walls, locomotor time 20.20.31.00.21.0-0.30.80.40.1-0.3-0.7-0.7-0.6
Bouts of movement, locomotor time 20.60.92.4-1.5-0.9-0.9-1.1-0.70.0-0.60.41.1-1.3
Total resting periods, locomotor time 20.51.02.1-1.4-1.0-1.0-1.1-0.80.2-0.60.61.1-1.2
Rest time, locomotor task time 20.30.41.00.20.30.90.10.9-0.20.4-0.80.5-1.0
Distance moved, locomotor task time 20.30.40.9-0.6-0.3-0.7-0.5-1.0-0.5-0.80.50.20.7
Vertical activity count, locomotor time 20.30.41.30.30.70.11.00.2-0.00.2-0.1-1.11.0
Light reinforcement 10.82.04.52.11.81.21.71.71.21.5-0.7-0.70.1
Light reinforcement 20.20.41.3-0.1-0.70.2-0.50.20.70.70.61.1-0.4
Bone: marrow area0.20.51.10.80.71.00.40.8-0.50.3-0.8-0.60.6
Bone: maximum diameter0.20.41.30.30.70.90.20.8-0.8-0.2-1.1-0.5-0.3
Bone: maximum force1.22.24.41.62.11.51.41.3-1.00.1-1.7-1.91.2
Bone: maximum moment1.42.44.41.82.11.51.61.2-0.80.3-1.4-2.11.7
Mean time between licks in bursts0.81.94.7-0.9-2.1-1.8-0.7-1.71.0-0.22.2-0.41.0
Mean num. licks in bursts0.20.41.10.80.60.10.80.41.10.70.2-0.30.6
Cd content in liver0.60.72.41.50.70.60.60.90.80.9-0.2-0.80.4
Co content in liver1.01.24.1-0.0-0.8-1.10.5-1.40.6-0.21.6-0.92.0
Cu content in liver0.80.93.01.00.70.31.50.10.40.60.4-1.31.7
Fe content in liver0.20.20.70.60.80.10.60.1-0.2-0.2-0.5-0.70.1
K content in liver0.90.82.5-0.9-0.70.2-1.10.1-0.9-0.6-0.71.2-1.6
Mg content in liver0.80.81.9-0.8-0.3-0.2-0.8-0.1-1.1-1.1-0.91.2-1.4
Mn content in liver0.40.51.2-0.9-0.70.7-0.60.2-0.70.1-0.21.1-0.8
Na content in liver1.21.23.61.21.70.11.90.40.20.1-0.6-1.80.9
Rb content in liver1.01.12.7-0.9-1.2-1.3-0.1-1.60.5-0.41.7-0.31.1
Se content in liver0.80.92.20.51.50.51.10.2-1.4-0.9-1.4-0.40.2
Sr content in liver1.91.63.11.10.81.71.21.30.71.8-0.2-1.71.3
Zn content in liver0.10.10.5-0.10.30.20.10.1-0.7-0.4-0.4-0.10.0
Bone: minimum diameter0.20.41.00.60.81.00.41.0-0.10.5-0.8-0.10.5
Time in familiar zone, hab. session 11.21.23.31.11.80.90.91.0-1.1-0.3-1.6-0.6-0.5
Time in novel zone, hab. session 10.50.51.1-0.5-1.1-1.0-0.4-0.71.00.11.00.20.5
Total zone transitions, hab. session 10.30.41.11.10.50.10.90.40.80.60.1-0.90.4
Total locomotion distance, hab. session 11.31.94.01.81.91.11.32.01.11.3-1.2-0.2-0.6
Locomotion velocity, hab. session 10.91.32.71.41.50.91.01.61.31.3-0.8-0.1-0.7
Time in familiar zone, hab. session 20.60.61.21.00.41.10.90.80.31.1-0.0-0.70.7
Time in novel zone, hab. session 20.80.82.2-1.2-0.2-1.2-0.9-1.0-0.7-1.5-0.20.5-0.8
Total zone transitions, hab. session 22.22.86.32.21.01.01.91.42.52.40.6-1.01.2
Total locomotion distance, hab. session 22.12.84.82.22.11.31.92.22.12.1-0.6-0.3-0.2
Locomotion velocity, hab. session 21.92.54.32.01.91.11.82.12.02.0-0.5-0.2-0.3
Novel to familiar place preference ratio0.20.30.6-0.3-0.1-0.6-0.6-0.7-0.4-0.80.10.50.4
Novelty place preference0.60.71.4-0.8-0.6-1.0-1.1-1.2-0.4-1.00.60.90.3
Time in novel zone, NPP test0.50.51.2-0.6-0.3-1.0-0.8-1.1-0.4-1.00.30.50.3
Total zone transitions, NPP test0.91.43.61.30.70.61.31.21.91.70.1-1.10.2
Total locomotion distance, NPP test1.52.05.01.61.21.01.41.82.22.2-0.0-0.5-0.0
Locomotion velocity, NPP test1.31.94.91.51.01.01.31.62.22.20.2-0.40.0
Intraocular pressure1.72.57.0-1.2-2.1-1.7-1.0-2.01.2-0.12.61.11.2
Delta distance traveled before/after self-admin0.90.92.41.21.30.90.61.3-0.60.1-1.6-0.0-0.7
Delta ambulatory time before/after self-admin1.01.34.41.21.30.40.31.0-1.3-0.8-2.1-0.0-1.3
Parametrial fat weight0.51.22.11.41.40.61.41.21.31.40.10.30.1
Pavlov. Cond. lever latency0.50.62.0-0.30.11.0-0.50.7-1.4-0.3-1.10.7-0.9
Pavlov. Cond. magazine entry latency0.70.91.91.00.5-0.41.1-0.21.40.81.0-1.01.4
Pavlov. Cond. change in total contacts0.40.51.10.70.7-0.20.8-0.11.00.50.4-0.90.9
Pavlov. Cond. index score0.81.02.31.20.7-0.21.20.11.50.90.7-1.21.4
Pavlov. Cond. latency score0.91.12.91.10.6-0.31.20.11.71.00.7-1.21.3
Pavlov. Cond. lever contacts1.31.54.20.90.1-1.11.0-0.72.00.71.5-1.31.7
Pavlov. Cond. magazine entry number1.11.43.2-1.2-0.40.1-1.30.0-1.8-1.3-1.21.2-1.8
Pavlov. Cond. intertrial magazine entries0.91.14.9-0.5-0.1-1.4-0.4-1.2-1.5-2.2-0.40.0-0.2
Pavlov. Cond. lever-magazine prob. diff.0.91.12.41.20.7-0.31.3-0.01.60.90.7-1.31.5
Pavlov. Cond. response bias0.91.12.61.00.4-0.51.1-0.31.60.91.1-0.91.6
Pavlov. Cond. lever latency0.50.72.10.10.91.40.41.0-1.10.2-1.3-0.2-0.3
Pavlov. Cond. magazine entry latency0.60.71.4-1.0-1.0-1.1-0.8-1.2-0.4-1.10.60.6-0.3
Pavlov. Cond. change in total contacts1.32.15.2-1.0-2.0-2.3-1.3-2.00.7-1.01.80.90.0
Pavlov. Cond. index score1.01.33.2-0.9-1.5-1.8-1.0-1.50.5-0.91.41.0-0.2
Pavlov. Cond. latency score1.01.33.1-0.9-1.4-1.8-1.1-1.50.3-1.11.11.1-0.6
Pavlov. Cond. lever contacts0.40.62.0-0.1-0.8-1.4-0.2-0.91.0-0.31.10.10.3
Pavlov. Cond. magazine entry number1.11.32.61.01.61.61.01.6-0.30.8-1.4-1.00.1
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.30.30.1-0.30.2-0.4-0.2-0.60.2-0.7
Pavlov. Cond. lever-magazine prob. diff.1.21.63.9-1.1-1.6-2.0-1.1-1.70.3-1.21.31.2-0.4
Pavlov. Cond. response bias0.91.33.3-0.5-1.5-1.6-0.6-1.51.1-0.31.80.20.7
Time in closed arm before self-admin0.10.21.20.60.10.0-0.1-0.20.20.10.31.10.3
Time in closed arm after self-admin2.22.35.32.31.41.22.01.01.01.50.0-1.52.0
Time in open arm before self-admin2.02.15.61.31.52.21.12.40.31.7-1.4-0.9-0.2
Time in open arm after self-admin0.60.71.8-1.3-0.40.2-1.0-0.1-1.3-0.7-0.50.5-1.1
Bone: periosteal estimation0.51.01.81.11.31.30.71.1-0.60.3-1.3-0.80.5
Bone: periosteal perimeter0.91.53.71.11.61.91.01.7-0.50.8-1.4-0.50.2
Bone: post-yield work1.42.15.50.82.21.70.91.6-1.7-0.3-2.4-1.00.0
Progressive ratio test 1 active lever presses0.70.92.7-1.4-0.3-0.5-0.5-0.7-1.7-1.5-0.5-0.3-0.3
Progressive ratio test 1 breakpoint0.81.03.2-1.5-0.3-0.5-0.6-0.8-1.8-1.7-0.6-0.3-0.4
Progressive ratio test 1 inactive lever presses0.50.81.90.20.31.31.20.80.31.40.3-0.31.3
Progressive ratio test 2 active lever presses0.80.93.1-0.80.4-0.4-0.3-0.5-1.8-1.6-1.10.1-0.8
Progressive ratio test 2 breakpoint0.81.03.4-0.80.4-0.4-0.3-0.5-1.9-1.7-1.10.1-0.8
Progressive ratio test 2 inactive lever presses0.10.10.7-0.7-0.1-0.1-0.1-0.2-0.2-0.20.10.80.2
Incentive Sensitization - Responses1.21.74.2-1.1-0.4-1.3-1.2-1.2-1.3-2.1-0.51.6-1.4
Incentive Sensitization - Breakpoint1.11.43.5-1.0-0.3-1.1-1.1-1.0-1.3-1.9-0.51.6-1.3
Sum of active levers in priming session hrs 5-62.52.35.5-2.3-0.9-0.1-2.0-0.4-2.3-1.7-0.91.3-1.6
Progressive ratio1.21.84.8-1.9-1.70.1-2.2-0.3-0.7-0.4-0.01.8-1.8
Food seeking constrained by brief footshock1.51.94.01.61.32.01.11.6-1.40.5-1.6-1.50.1
Seeking ratio, punishment vs. effort2.13.17.72.82.31.42.41.50.00.9-1.0-1.91.7
Retroperitoneal fat weight0.62.76.91.91.62.11.61.71.62.60.2-0.20.9
Reaction time number correct0.30.61.2-0.8-0.9-1.1-0.9-0.90.3-0.60.60.7-0.3
Reaction time mean minus median0.41.13.60.3-1.1-0.4-0.2-0.81.30.81.90.51.6
Reaction time mean minus median AUC0.51.44.50.4-1.1-0.90.0-1.31.20.42.1-0.12.1
Reaction time num false alarms1.72.45.71.82.41.32.31.2-0.30.5-1.4-1.80.9
Reaction time num false alarms AUC1.21.84.71.52.21.12.01.1-0.40.4-1.3-1.50.7
Reaction time trials correct on left0.30.61.2-0.8-0.9-1.1-0.9-0.90.3-0.60.60.7-0.3
Reaction time trials on left0.30.51.0-0.7-0.9-1.0-0.8-0.90.3-0.60.60.7-0.2
Reaction time mean1.11.85.40.9-0.90.20.0-0.12.31.92.10.71.5
Reaction time mean AUC0.71.13.10.7-0.80.2-0.1-0.11.81.51.60.81.2
Median of all reaction times1.01.44.50.7-0.90.2-0.10.02.11.81.80.81.1
Reaction time omissions0.30.41.60.70.40.90.30.2-0.90.0-0.3-0.21.3
Reaction time false alarm rate1.72.45.11.72.21.62.31.4-0.30.8-1.2-1.81.0
Reaction time premature initiation rate0.60.92.4-0.80.1-1.0-0.9-0.6-0.5-1.4-0.60.9-1.5
Reaction time premature initiations0.81.42.9-1.2-0.4-1.5-1.4-1.1-0.4-1.6-0.31.2-1.7
Std. dev. reaction times0.71.33.41.3-0.30.50.60.21.61.61.40.01.9
Reaction time trials completed0.30.51.0-0.7-0.9-1.0-0.8-0.90.3-0.60.60.7-0.2
Reaction time trials AUC0.20.40.8-0.5-0.7-0.9-0.7-0.70.3-0.50.50.5-0.2
Run reversals in cocaine runway, females0.70.72.21.00.4-0.01.0-0.10.20.20.3-1.51.5
Run reversals in cocaine runway, males0.30.30.80.90.50.20.4-0.1-0.4-0.3-0.2-0.80.9
Latency to leave start box in cocaine runway0.40.51.2-0.20.60.00.4-0.1-1.1-1.0-1.1-1.0-0.4
Latency to leave start box in cocaine runway, F0.30.31.0-0.50.10.40.00.1-1.0-0.6-0.9-0.3-0.8
Latency to leave start box in cocaine runway, M0.40.41.50.20.6-0.60.4-0.4-0.4-0.8-0.4-1.20.6
Std. dev. time between licks in bursts0.10.10.5-0.2-0.2-0.7-0.1-0.30.3-0.30.2-0.7-0.1
Total sessions with >9 infusions0.40.41.1-0.9-0.30.3-0.80.2-0.7-0.3-0.51.0-1.0
Short access day 1 total inactive lever presses0.30.41.20.21.10.20.80.4-0.9-0.5-1.0-0.4-0.3
Short access day 10 total inactive lever presses0.81.95.42.31.21.51.41.51.11.8-0.00.01.3
Short access day 1 total infusions0.20.20.7-0.20.30.90.30.6-0.40.5-0.2-0.40.3
Short access day 10 total infusions0.50.61.6-1.1-0.20.6-0.80.5-1.0-0.2-0.80.8-1.2
Short access total infusions0.20.20.6-0.8-0.00.6-0.20.4-0.80.0-0.50.2-0.5
Short access day 1 locomotion0.80.93.00.50.61.70.41.60.31.6-0.40.1-0.2
Short access day 10 total locomotion1.73.16.3-2.3-2.5-1.4-2.4-1.8-0.6-1.21.32.1-0.9
Short access total locomotion0.50.62.2-0.8-0.40.8-0.80.5-0.50.3-0.31.5-0.9
One hour access (0.3 mA shock)1.11.32.6-1.2-1.0-1.0-1.5-0.9-1.2-1.6-0.31.2-0.9
Compulsive drug intake0.40.51.20.2-1.1-0.3-0.7-0.21.10.61.00.80.4
One hour access (shock baseline)0.61.03.5-0.80.10.1-0.7-0.1-1.9-1.4-1.30.4-1.1
Social response proportion1.21.44.3-1.0-0.7-2.1-0.3-1.90.5-1.01.5-0.40.7
Social responses1.11.45.7-1.1-0.5-2.4-0.5-1.80.4-1.41.00.3-0.4
Social time2.63.56.0-2.1-1.9-2.4-2.4-1.60.1-1.80.82.2-2.0
Soleus weight2.36.715.53.92.92.73.02.71.72.8-0.9-2.21.9
Bone: stiffness0.50.72.40.41.00.50.30.2-1.5-1.0-1.4-0.70.3
Tibialis anterior weight1.13.68.12.32.12.81.42.80.72.3-1.4-0.30.1
Time to tail flick, vehicle, before self-admin1.91.95.9-0.8-0.7-2.2-1.0-2.2-1.1-2.40.4-0.30.3
Time to tail flick, vehicle, after self-admin0.20.30.7-0.2-0.8-0.4-0.1-0.8-0.2-0.20.8-0.40.9
Time to tail flick, test, before self-admin1.01.14.6-0.30.60.10.6-0.5-2.2-1.4-1.1-1.20.3
Time to tail flick, test, after self-admin1.71.87.1-0.31.1-0.10.3-0.3-2.7-2.2-2.0-0.4-0.6
Delta time to tail flick, vehicle, before/after SA0.80.72.30.80.41.50.81.40.01.2-0.5-0.30.0
Delta time to tail flick, test, before/after SA0.20.20.50.10.4-0.1-0.10.40.1-0.2-0.50.6-0.7
Tibia length0.10.20.8-0.2-0.90.2-0.4-0.3-0.3-0.00.40.20.6
Ambulatory time before self-admin0.20.30.90.50.90.40.80.50.00.4-0.2-0.70.6
Ambulatory time after self-admin1.82.16.12.12.50.71.71.4-0.30.2-1.6-1.50.3
Bone: tissue strength0.30.30.80.40.60.80.20.9-0.10.4-0.80.1-0.3
Total heroin consumption0.20.20.6-0.00.1-0.2-0.6-0.1-0.6-0.8-0.6-0.5-0.1
Bone: trabecular number4.06.614.42.53.82.92.72.5-2.40.1-3.5-2.40.6
Bone: trabecular spacing2.23.06.3-2.3-2.3-1.5-2.5-1.60.3-0.91.21.8-1.5
Bone: trabecular thickness1.21.52.81.51.71.21.51.1-1.4-0.2-1.6-0.60.5
Bone: trabecular tissue density1.01.55.5-1.0-0.7-0.8-1.2-0.3-0.5-0.9-0.32.1-2.3
Water consumed over 24 hours0.60.82.2-0.9-0.5-1.5-0.8-0.80.5-0.80.40.7-1.2
Number of responses in last shaping day0.50.51.30.20.4-0.01.0-0.20.80.70.8-1.01.1