Hub : Genes

Hoxb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_039086075.1	0.02	0.02	7.6e-03	0.02	0.02	0.02	0.02	3.1e-03	7.5e-03	9.1e-03	7.0e-03
2	Adipose	mRNA stability	Hoxb3	0.06	0.06	1.4e-03	0.02	0	0.01	-0	2.6e-03	8.9e-02	3.3e-02	7.2e-01
3	Adipose	gene expression	Hoxb3	0.11	0.09	7.7e-10	0.07	0.06	0.08	0.08	6.0e-08	7.5e-07	6.9e-09	6.7e-09
4	NAcc	alternative TSS	XM_017597314.2	0.07	0.07	6.4e-03	0.02	0.01	0.02	0.02	9.7e-04	1.7e-02	1.7e-03	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.5	2.4	2.7	1.6	1.6	-1.6	1.4
Area under the delay curve	0.2	0.2	0.3	0.1	0.1	0.5	-0.6
BMI with tail	16.0	51.9	61.4	7.8	7.8	-6.8	6.3
BMI without tail	1.1	2.2	2.7	1.3	1.4	-1.6	1.6
Body weight	0.9	3.8	5.5	2.3	2.3	-1.5	1.4
Weight adjusted by age	0.4	0.5	0.9	-0.1	-0.3	0.9	-1.0
Bone surface	0.4	0.7	1.1	1.0	1.0	-0.8	0.5
Bone volume	1.1	2.0	2.1	1.4	1.4	-1.5	1.2
Breakpoint value in progressive ratio session	4.0	4.4	5.6	-1.9	-2.0	2.1	-2.4
Number of licking bursts	0.5	0.5	1.1	-1.0	-0.9	0.4	-0.3
Context. condit. distance diff. score	0.7	0.9	1.6	1.3	1.2	-0.5	0.5
Locomotion velocity, session 1	0.2	0.3	0.6	-0.1	-0.1	-0.7	0.8
Locomotion distance, session 1	3.5	4.5	6.1	-2.5	-2.4	1.7	-1.7
Locomotion velocity, session 2	1.0	1.2	1.6	-1.2	-1.3	1.0	-0.9
Locomotion distance, session 2	4.7	6.5	9.5	-3.0	-3.1	2.0	-2.0
Locomotion velocity, session 3	0.2	0.2	0.5	0.7	0.5	0.1	-0.1
Locomotion distance, session 3	2.1	2.3	3.5	-1.1	-1.2	1.9	-1.8
Stereotopy head waving bouts, day 3	4.4	5.1	5.9	2.3	2.1	-2.4	2.2
Stereotopy head waving duration, day 3	3.4	4.0	4.5	2.1	1.9	-2.1	1.9
Locomotion velocity, session 7	1.1	1.2	1.5	-1.1	-0.9	1.1	-1.2
Locomotion distance, session 7	5.1	6.5	7.0	-2.6	-2.5	2.5	-2.5
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	0.7	0.5	-0.8	0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.3	0.5	0.3	-0.5	0.5
Locomotion velocity, session 8	0.2	0.3	0.4	0.6	0.6	-0.5	0.2
Locomotion distance, session 8	0.5	0.7	0.9	-0.8	-0.8	0.9	-0.9
Degree of sensitization distance	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.5	-0.7	0.3	-0.2
Conditioned locomotion	1.4	1.7	2.4	1.5	1.4	-1.2	1.0
Cocaine response after cond. corrected	5.8	6.5	6.9	2.5	2.6	-2.6	2.5
Cocaine response after cond. not corrected	3.3	3.7	4.1	1.9	2.0	-1.9	1.9
Cocaine response before conditioning	2.6	3.1	3.5	-1.9	-1.8	1.7	-1.7
Saline control response	0.2	0.2	0.5	0.4	0.5	0.2	-0.7
Bone: connectivity density	0.3	0.4	0.7	0.8	0.9	-0.4	0.2
Bone: cortical apparent density	6.1	8.0	9.5	-2.7	-2.6	2.9	-3.1
Bone: cortical area	0.3	0.4	0.8	0.9	0.9	-0.2	0.1
Bone: cortical porosity	0.5	0.5	0.7	0.7	0.7	-0.6	0.9
Bone: cortical porosity	0.4	0.4	0.6	0.5	0.6	-0.6	0.8
Bone: cortical thickness	0.2	0.3	0.5	0.5	0.4	0.5	-0.7
Bone: cortical thickness	0.9	1.0	1.9	-0.6	-0.7	1.1	-1.4
Bone: cortical tissue density	6.6	8.7	10.0	-2.8	-2.8	3.0	-3.2
Condit. Reinf. active minus inactive responses	0.7	0.8	1.4	-1.2	-1.2	0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	-0.0	-0.4	0.5
Condit. Reinf. active responses	0.7	0.9	1.6	-1.2	-1.3	0.4	-0.4
Condit. Reinf. inactive responses	0.7	0.9	1.2	-1.1	-1.1	0.7	-0.8
Incentive salience index mean	1.3	1.5	2.6	-1.6	-1.6	0.7	-0.5
Condit. Reinf. lever presses	1.8	2.4	3.6	-1.9	-1.9	1.2	-1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.3	-0.2	-0.6	0.9
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.0	0.1	0.2
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.0	0.2	0.5	-0.6
Condit. Reinf. lever presses	0.5	0.7	1.2	-0.7	-0.7	1.1	-0.8
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.3	0.0	0.3	-0.1
Conditioned reinforcement - actives	0.7	0.7	1.9	-0.3	0.1	-0.9	1.4
Conditioned reinforcement - inactives	0.2	0.3	0.8	-0.0	0.3	0.5	-0.9
Conditioned locomotion	2.5	3.0	7.5	0.4	0.6	-1.9	2.7
Patch foraging indifference point 0 sec	1.1	1.8	2.5	1.6	1.3	-1.1	1.3
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.1	-0.2	0.4	-0.4
Delay disc. indifference point, 0s delay	0.5	0.6	1.2	0.2	0.2	1.0	-1.1
Delay disc. indifference point, 16s delay	0.8	0.8	1.3	1.1	1.1	-0.6	0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.0	-0.1	0.4	-0.3
Delay disc. indifference point, 24s delay	0.6	0.6	0.6	-0.8	-0.8	0.8	-0.7
Delay disc. indifference point, 4s delay	2.1	2.2	3.9	-0.8	-0.9	1.9	-2.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.1	-0.1	0.5	-0.4
Indifference point function ln k	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2
Indifference point function log k	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2
Patch foraging total patch changes 0 sec	1.2	2.0	2.9	1.7	1.4	-1.1	1.3
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	0.5	0.4	-0.3	0.5
Patch foraging total patch changes 18 sec	2.1	2.6	3.5	1.9	1.8	-1.3	1.4
Patch foraging total patch changes 24 sec	1.3	1.6	2.0	1.2	1.1	-1.4	1.3
Patch foraging total patch changes 6 sec	1.0	1.4	2.0	1.4	1.2	-0.9	1.2
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.3
Patch foraging water rate 0 sec	1.3	2.0	3.3	1.8	1.6	-1.1	1.0
Patch foraging water rate 12 sec	0.3	0.5	1.0	1.0	0.9	0.3	-0.3
Patch foraging water rate 18 sec	0.2	0.3	0.7	0.1	-0.2	0.6	-0.8
Patch foraging water rate 24 sec	1.0	1.4	2.2	1.5	1.2	-1.0	0.9
Patch foraging water rate 6 sec	0.1	0.1	0.1	0.4	0.3	-0.0	-0.4
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.6	1.4	1.6	-0.6	0.3
Distance traveled before self-admin	1.1	1.1	1.8	-1.3	-1.3	0.9	-0.6
Distance traveled after self-admin	0.8	0.8	2.3	0.5	0.6	-0.7	1.5
Extensor digitorum longus weight	0.5	2.0	3.7	1.9	1.9	-0.5	0.7
Bone: elastic displacement	0.1	0.1	0.3	0.1	0.1	-0.5	0.5
Bone: elastic work	0.0	0.0	0.0	0.1	0.1	0.0	0.2
Bone: endosteal estimation	0.2	0.4	0.6	0.4	0.5	-0.7	0.8
Bone: endosteal perimeter	0.3	0.7	1.1	0.6	0.7	-0.9	1.1
Epididymis fat weight	0.1	0.3	0.8	0.7	0.9	0.0	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.2	0.3	0.3	-0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.1	-0.2	0.4	-0.5
Diff in mean of infusions in LGA sessions	1.2	1.3	1.9	-1.4	-1.3	0.8	-1.0
Delay discount exponential model param	0.2	0.2	0.4	0.0	0.0	-0.6	0.6
Extinction: sum of active levers before priming	1.0	1.0	1.4	-0.8	-0.8	1.2	-1.1
Active lever presses in extinction session 6	0.1	0.1	0.2	0.2	0.1	-0.3	0.4
Bone: final force	0.2	0.3	0.4	0.6	0.7	-0.5	0.5
Bone: final moment	0.3	0.5	0.6	0.7	0.8	-0.6	0.6
Food consumed during 24 hour testing period	1.9	2.3	2.9	-1.6	-1.7	1.5	-1.3
Glucose	0.7	1.0	1.4	1.2	1.0	-1.0	0.8
Heart weight	1.6	2.3	2.7	1.5	1.6	-1.6	1.4
Delay discount hyperbolic model param	0.3	0.3	0.7	0.1	0.1	-0.8	0.8
Intermittent access intake day 1-15 change	2.0	2.0	3.1	1.1	1.0	-1.6	1.8
Intermittent access intake escalation	1.7	1.7	3.3	0.8	0.7	-1.5	1.8
Intermittent access intake escalation 2	1.4	1.4	2.2	0.8	0.8	-1.5	1.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	0.1	0.3	0.3	-0.7
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.2	1.3	1.5	-0.8	0.4
Intermitt. access escalation Index	1.0	0.9	2.0	-0.3	-0.5	-1.1	1.4
Intermittent access day 1 total infusions	0.7	0.8	1.2	-1.1	-0.9	0.9	-0.5
Intermittent access day 15 total infusions	0.3	0.3	0.4	-0.7	-0.5	-0.2	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	-0.3	-0.1	-0.3	0.4
Intermittent access total infusions	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1
Intermittent access day 1 locomotion	1.3	1.3	2.6	-1.6	-1.5	0.6	-0.4
Intermittent access day 15 total locomotion	0.3	0.3	0.4	-0.5	-0.5	-0.5	0.6
Intermittent access total locomotion	0.5	0.6	1.1	-0.7	-0.6	-0.6	1.0
Intermittent access standard deviation	1.7	1.8	2.8	1.1	1.0	-1.7	1.5
Left kidney weight	0.0	0.0	0.1	0.2	0.2	0.1	-0.2
Right kidney weight	0.4	1.2	1.6	1.3	1.2	-0.9	1.0
Cocaine induced anxiety	0.1	0.1	0.1	0.3	0.4	-0.4	0.3
Post-drug Anxiety	0.6	0.6	0.7	-0.9	-0.8	0.6	-0.8
Baseline Anxiety	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.3
Tail length	14.3	43.2	52.5	-7.2	-7.2	6.2	-5.6
Length with tail	7.2	26.5	27.8	-5.3	-5.3	5.2	-4.9
Length without tail	0.1	0.3	0.4	0.4	0.4	0.6	-0.6
Times rat made contact with spout	0.5	0.6	1.1	-1.0	-1.0	0.3	-0.3
Lifetime Intake	0.1	0.1	0.3	-0.5	-0.5	0.3	-0.1
Liver weight, left	0.8	1.3	1.3	-1.2	-1.1	1.2	-1.1
Liver weight, right	0.7	1.1	2.2	-0.6	-0.6	1.3	-1.5
Locomotor activity	0.3	0.5	0.8	0.6	0.6	-0.9	0.7
Locomotor testing distance	0.7	1.2	1.5	1.0	1.0	-1.2	1.1
Locomotor testing rearing	0.1	0.2	0.3	0.5	0.6	-0.3	-0.0
Locomotion in novel chamber	0.3	0.4	1.0	-0.1	-0.0	0.8	-1.0
Locomotion in novel chamber post-restriction	1.9	2.3	2.7	1.6	1.5	-1.3	1.6
Fecal boli incidents, locomotor time 1	2.7	3.0	4.1	1.6	1.5	-2.0	1.7
Change in fecal boli incidents, locomotor task	2.0	1.8	2.8	-1.2	-1.1	1.7	-1.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	0.0	0.6	-0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.5	0.7	-0.3	0.1
Total resting periods, locomotor time 1	0.4	0.5	0.9	0.8	1.0	-0.5	0.3
Rest time, locomotor task time 1	0.2	0.2	0.3	0.3	0.2	-0.5	0.5
Distance moved, locomotor task time 1	1.7	1.9	2.7	-1.6	-1.6	1.1	-1.0
Vertical activity count, locomotor time 1	0.3	0.3	0.4	-0.6	-0.7	0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	-0.5	-0.6	0.8	-0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.3	0.3	-0.4	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	0.4	-0.4	0.3
Rest time, locomotor task time 2	0.9	1.1	1.7	-0.8	-0.9	1.1	-1.3
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.0	-0.1	-0.1	0.6
Light reinforcement 1	0.2	0.3	0.6	0.1	0.2	-0.8	0.7
Light reinforcement 2	0.3	0.4	0.7	-0.9	-0.8	-0.0	0.2
Bone: marrow area	0.1	0.2	0.4	0.3	0.4	-0.5	0.6
Bone: maximum diameter	0.3	0.6	0.7	0.8	0.8	-0.8	0.8
Bone: maximum force	0.6	1.1	1.5	1.2	1.2	-0.8	0.8
Bone: maximum moment	0.7	1.3	1.8	1.3	1.3	-0.9	0.9
Mean time between licks in bursts	0.6	0.8	1.6	1.1	1.3	-0.4	0.5
Mean num. licks in bursts	0.0	0.0	0.1	0.2	0.1	0.2	-0.3
Cd content in liver	0.4	0.4	0.9	-0.2	-0.3	0.7	-0.9
Co content in liver	0.0	0.0	0.1	0.2	0.2	-0.3	0.1
Cu content in liver	5.7	6.9	11.1	-3.3	-3.3	1.8	-1.6
Fe content in liver	1.5	1.8	2.0	-1.4	-1.4	1.3	-1.4
K content in liver	0.3	0.3	0.5	-0.7	-0.6	-0.5	0.3
Mg content in liver	1.4	1.4	2.3	-1.5	-1.4	0.8	-1.0
Mn content in liver	3.5	3.9	5.1	-2.2	-2.3	1.7	-1.7
Na content in liver	0.7	0.7	0.9	-0.8	-0.6	-1.0	1.0
Rb content in liver	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.6
Se content in liver	0.2	0.3	0.4	0.5	0.4	-0.7	0.4
Sr content in liver	1.3	1.2	1.9	-0.9	-0.9	1.4	-1.0
Zn content in liver	0.0	0.0	0.1	-0.0	-0.0	-0.3	0.2
Bone: minimum diameter	0.0	0.0	0.1	0.1	0.3	-0.2	0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.1	-0.1	0.7	-0.8
Time in novel zone, hab. session 1	2.5	2.4	3.4	1.3	1.2	-1.8	1.8
Total zone transitions, hab. session 1	6.5	9.1	9.5	-3.1	-3.0	3.0	-3.0
Total locomotion distance, hab. session 1	3.2	4.6	5.7	-2.4	-2.2	1.9	-2.0
Locomotion velocity, hab. session 1	4.1	5.8	7.1	-2.7	-2.5	2.2	-2.3
Time in familiar zone, hab. session 2	0.8	0.8	1.3	1.1	1.1	-0.7	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2
Total zone transitions, hab. session 2	3.3	4.3	6.2	-2.5	-2.4	1.6	-1.5
Total locomotion distance, hab. session 2	0.5	0.7	1.4	-1.2	-1.1	0.2	-0.1
Locomotion velocity, hab. session 2	0.7	0.9	1.8	-1.4	-1.3	0.3	-0.2
Novel to familiar place preference ratio	0.5	0.5	1.0	-0.3	-0.3	0.9	-1.0
Novelty place preference	0.6	0.6	1.3	-0.2	-0.3	1.0	-1.1
Time in novel zone, NPP test	0.4	0.5	1.0	-0.1	-0.1	0.9	-1.0
Total zone transitions, NPP test	4.7	6.7	8.7	-2.9	-2.9	2.2	-2.1
Total locomotion distance, NPP test	1.2	1.6	2.4	-1.5	-1.5	1.0	-0.9
Locomotion velocity, NPP test	1.7	2.5	3.3	-1.8	-1.8	1.3	-1.2
Intraocular pressure	1.2	1.7	2.6	-1.1	-1.0	1.6	-1.4
Delta distance traveled before/after self-admin	2.7	2.9	3.7	1.7	1.8	-1.3	1.9
Delta ambulatory time before/after self-admin	2.8	3.0	3.8	1.7	1.8	-1.5	2.0
Parametrial fat weight	0.0	0.1	0.1	-0.4	-0.4	0.1	0.1
Pavlov. Cond. lever latency	1.3	1.7	1.8	1.3	1.3	-1.3	1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.0
Pavlov. Cond. change in total contacts	3.0	3.2	3.9	-2.0	-2.0	1.7	-1.6
Pavlov. Cond. index score	0.7	0.9	1.3	-1.1	-1.0	0.9	-0.6
Pavlov. Cond. latency score	0.8	1.0	1.4	-1.2	-1.0	0.9	-0.7
Pavlov. Cond. lever contacts	2.2	2.5	2.8	-1.7	-1.7	1.6	-1.4
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	0.8	0.7	-0.6	0.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.1	-1.0	-1.0	0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.1	-1.0	-0.9	0.8	-0.6
Pavlov. Cond. response bias	0.6	0.7	0.8	-0.9	-0.9	0.9	-0.7
Pavlov. Cond. lever latency	1.1	1.5	2.3	-1.5	-1.3	1.0	-0.9
Pavlov. Cond. magazine entry latency	0.6	0.7	1.2	-0.9	-1.1	0.7	-0.6
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.7	0.6	-0.5	0.6
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	0.4	-0.6	0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.1	-0.4	0.4
Pavlov. Cond. lever contacts	0.8	1.0	1.5	1.2	1.0	-0.9	0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	1.4	1.9	2.5	-1.2	-1.1	1.5	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.7	0.5	-0.7	0.7
Pavlov. Cond. response bias	0.6	0.8	1.0	1.0	0.9	-0.9	0.8
Time in closed arm before self-admin	2.5	2.9	4.8	1.9	2.2	-1.5	1.0
Time in closed arm after self-admin	2.2	2.2	4.4	1.8	2.1	-0.9	0.7
Time in open arm before self-admin	0.4	0.4	0.7	-0.6	-0.6	0.9	-0.1
Time in open arm after self-admin	0.5	0.5	1.0	-0.4	-0.8	1.0	-0.6
Bone: periosteal estimation	0.4	0.8	1.0	0.9	1.0	-0.8	0.8
Bone: periosteal perimeter	0.7	1.2	1.9	1.3	1.4	-0.8	0.8
Bone: post-yield work	0.4	0.6	1.2	1.0	1.1	-0.4	0.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.1	-1.0	-0.9	0.7	-0.2
Progressive ratio test 1 breakpoint	0.8	0.8	1.3	-1.1	-1.0	0.9	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.4	0.5	-0.1	0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.8	-0.5	0.6	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.5	-0.1	0.4	-0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.2	0.5	0.2	-0.4
Incentive Sensitization - Responses	0.1	0.1	0.4	0.2	0.6	-0.1	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	0.4	0.8	-0.3	0.5
Sum of active levers in priming session hrs 5-6	4.8	4.6	5.7	-2.4	-2.3	1.9	-1.9
Progressive ratio	0.2	0.2	0.5	0.5	0.4	-0.1	-0.7
Food seeking constrained by brief footshock	0.3	0.4	0.9	-0.0	0.2	-0.8	0.9
Seeking ratio, punishment vs. effort	0.5	0.6	0.9	-1.0	-0.9	0.2	0.8
Retroperitoneal fat weight	0.4	1.2	1.7	1.0	1.0	-1.1	1.3
Reaction time number correct	0.8	1.1	2.6	1.3	1.6	0.1	-0.5
Reaction time mean minus median	1.6	2.1	3.6	-1.7	-1.9	1.2	-0.6
Reaction time mean minus median AUC	2.1	2.7	4.5	-2.0	-2.1	1.3	-0.7
Reaction time num false alarms	0.7	0.9	1.6	-1.3	-1.2	0.7	-0.3
Reaction time num false alarms AUC	0.7	1.0	1.6	-1.3	-1.3	0.7	-0.4
Reaction time trials correct on left	0.8	1.1	2.6	1.3	1.6	0.1	-0.5
Reaction time trials on left	0.7	1.1	2.4	1.3	1.6	0.1	-0.5
Reaction time mean	0.8	1.1	2.1	-1.4	-1.4	0.5	0.2
Reaction time mean AUC	1.0	1.3	2.5	-1.5	-1.6	0.6	0.2
Median of all reaction times	0.3	0.5	0.8	-0.9	-0.8	-0.1	0.6
Reaction time omissions	0.7	1.0	1.8	-1.3	-1.3	0.5	-0.1
Reaction time false alarm rate	1.1	1.5	3.2	-1.6	-1.8	0.5	0.0
Reaction time premature initiation rate	0.4	0.5	0.8	-0.5	-0.9	0.8	-0.5
Reaction time premature initiations	0.3	0.4	0.9	0.0	-0.1	1.0	-0.8
Std. dev. reaction times	1.4	2.0	3.6	-1.8	-1.9	1.0	-0.3
Reaction time trials completed	0.7	1.1	2.4	1.3	1.6	0.1	-0.5
Reaction time trials AUC	0.8	1.1	2.5	1.3	1.6	0.2	-0.5
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.5	-0.4	0.5	-0.2
Run reversals in cocaine runway, males	1.3	1.3	1.9	1.4	1.4	-0.8	0.9
Latency to leave start box in cocaine runway	4.3	4.6	6.3	2.5	2.4	-1.9	1.6
Latency to leave start box in cocaine runway, F	6.5	7.1	9.4	3.1	3.0	-2.4	2.2
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	0.4	0.3	-0.9	0.5
Std. dev. time between licks in bursts	1.0	1.2	1.8	0.9	0.9	-1.2	1.4
Total sessions with >9 infusions	0.7	0.8	1.3	-1.1	-1.1	-0.2	0.8
Short access day 1 total inactive lever presses	2.0	2.2	5.6	-0.3	-0.1	1.8	-2.4
Short access day 10 total inactive lever presses	0.6	0.7	1.1	0.8	1.0	0.6	-1.0
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.2
Short access day 10 total infusions	0.2	0.2	0.4	-0.3	-0.2	-0.4	0.6
Short access total infusions	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1
Short access day 1 locomotion	0.5	0.5	1.0	-0.2	-0.1	-1.0	1.0
Short access day 10 total locomotion	0.9	1.0	1.4	-1.2	-1.1	-0.8	0.9
Short access total locomotion	0.7	0.7	1.2	-0.6	-0.5	-1.1	1.0
One hour access (0.3 mA shock)	0.5	0.6	0.9	-0.8	-0.6	1.0	-0.7
Compulsive drug intake	7.4	7.5	8.9	-2.7	-2.6	3.0	-2.7
One hour access (shock baseline)	2.1	2.4	3.2	1.2	1.3	-1.8	1.8
Social response proportion	1.8	1.9	3.2	-1.7	-1.8	0.9	-0.8
Social responses	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.3
Social time	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1
Soleus weight	1.4	4.0	5.1	2.1	2.3	-1.9	1.7
Bone: stiffness	0.1	0.1	0.3	0.5	0.5	-0.1	0.1
Tibialis anterior weight	0.2	0.7	1.5	-0.5	-0.4	1.2	-0.9
Time to tail flick, vehicle, before self-admin	2.2	2.3	4.0	-1.3	-1.3	1.4	-2.0
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.0	0.9	1.0	-0.4	0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.5	0.5	-0.5	-0.0
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.6	0.6	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	2.8	2.8	3.6	1.8	1.9	-1.3	1.6
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.5	-0.7	0.6	-0.2
Tibia length	0.5	1.4	2.2	1.3	1.5	-1.0	0.9
Ambulatory time before self-admin	0.5	0.5	0.8	-0.9	-0.9	0.7	-0.3
Ambulatory time after self-admin	1.3	1.4	3.2	0.8	0.9	-0.9	1.8
Bone: tissue strength	0.7	0.7	1.4	1.1	1.2	-0.3	0.4
Total heroin consumption	1.3	1.5	2.7	-0.9	-0.8	1.4	-1.6
Bone: trabecular number	0.4	0.6	1.1	0.5	0.6	-1.0	0.9
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	-0.0	0.1	0.0
Bone: trabecular thickness	2.5	3.0	4.5	2.1	2.0	-1.3	1.3
Bone: trabecular tissue density	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.2
Water consumed over 24 hours	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.6
Number of responses in last shaping day	1.3	1.3	2.8	1.7	1.6	-0.3	0.0