Hormad2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr14_79274240_79281537	0.16	0.12	8.9e-03	0.03	0.03	0.02	0.05	2.2e-02	1.3e-02	3.4e-02	3.3e-03
2	Liver	gene expression	Hormad2	0.06	0.06	3.7e-03	0.01	0	0.01	0.01	7.3e-03	9.8e-02	6.5e-02	7.1e-02
3	Adipose	gene expression	Hormad2	0.14	0.09	7.7e-05	0.02	0.03	0.03	0.02	1.7e-03	2.7e-04	5.2e-04	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.7	1.1	2.0	-0.6	1.4	-1.0
Area under the delay curve	2.9	3.0	9.0	3.0	-0.2	-0.1
BMI with tail	0.1	0.4	1.1	0.4	-0.3	1.0
BMI without tail	0.4	0.7	1.4	-0.0	1.2	-0.9
Body weight	0.4	1.7	4.7	2.2	0.5	-0.4
Weight adjusted by age	0.7	0.7	1.0	0.8	1.0	-0.8
Bone surface	0.1	0.2	0.4	0.6	0.6	-0.2
Bone volume	0.2	0.4	0.6	0.4	0.8	-0.6
Breakpoint value in progressive ratio session	0.1	0.2	0.3	0.5	-0.4	0.1
Number of licking bursts	1.4	1.7	2.5	1.4	0.8	-1.6
Context. condit. distance diff. score	1.4	1.7	4.9	-2.2	-0.1	0.5
Locomotion velocity, session 1	2.6	2.8	4.4	0.1	-2.0	2.1
Locomotion distance, session 1	0.7	0.9	2.2	-1.5	0.7	0.1
Locomotion velocity, session 2	2.2	2.6	4.7	0.2	-2.2	1.7
Locomotion distance, session 2	1.0	1.3	1.9	-1.4	-0.8	1.2
Locomotion velocity, session 3	0.7	0.8	2.2	-1.5	0.5	0.3
Locomotion distance, session 3	0.4	0.4	0.6	0.8	-0.4	0.7
Stereotopy head waving bouts, day 3	0.4	0.5	1.3	-1.1	0.2	0.2
Stereotopy head waving duration, day 3	1.1	1.3	3.3	-1.8	-0.1	0.7
Locomotion velocity, session 7	0.4	0.4	0.5	0.6	-0.5	0.7
Locomotion distance, session 7	0.6	0.8	1.6	-0.7	-0.6	1.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.3	0.1	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.1	0.6	-0.4
Locomotion velocity, session 8	1.5	1.8	2.6	-1.1	-1.6	1.2
Locomotion distance, session 8	3.1	4.6	12.9	-3.6	-0.3	0.9
Degree of sensitization distance	1.8	1.8	4.9	-2.2	-0.4	0.6
Degree of sensitization stereotypy	0.3	0.3	0.4	0.4	0.6	-0.6
Conditioned locomotion	0.7	0.8	1.3	-0.8	1.1	-0.8
Cocaine response after cond. corrected	0.3	0.4	0.9	1.0	0.4	-0.1
Cocaine response after cond. not corrected	0.7	0.8	1.7	1.3	0.7	-0.3
Cocaine response before conditioning	0.0	0.0	0.1	-0.1	0.3	0.0
Saline control response	1.1	1.5	2.6	-1.1	-0.8	1.6
Bone: connectivity density	0.4	0.7	1.4	-0.7	1.2	-0.4
Bone: cortical apparent density	0.1	0.1	0.3	0.1	0.2	-0.5
Bone: cortical area	0.8	1.3	3.7	1.9	0.2	-0.2
Bone: cortical porosity	0.5	0.6	1.0	0.5	1.0	-0.7
Bone: cortical porosity	0.3	0.3	0.6	0.1	0.8	-0.6
Bone: cortical thickness	0.8	1.3	2.2	1.5	1.0	-0.9
Bone: cortical thickness	1.2	1.4	2.8	-0.6	1.7	-1.0
Bone: cortical tissue density	0.1	0.1	0.2	0.2	0.1	-0.5
Condit. Reinf. active minus inactive responses	1.9	2.1	4.1	0.4	-1.4	2.0
Condit. Reinf. active-inactive response ratio	4.2	4.5	7.2	-0.1	-2.5	2.7
Condit. Reinf. active responses	0.8	1.0	2.2	0.1	-0.9	1.5
Condit. Reinf. inactive responses	0.5	0.6	1.0	0.2	1.0	-0.9
Incentive salience index mean	1.3	1.6	2.7	1.0	-1.1	1.6
Condit. Reinf. lever presses	0.2	0.3	0.7	0.8	-0.1	0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.8	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	0.0	0.4
Condit. Reinf. active responses	0.7	1.0	2.3	-1.5	-0.3	0.8
Condit. Reinf. inactive responses	1.1	1.4	3.2	-1.8	-0.5	0.8
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.9	0.3	0.3
Condit. Reinf. lever reinforcers received	0.7	1.0	2.0	-1.4	-0.2	1.0
Conditioned reinforcement - actives	1.2	1.2	1.3	1.0	-1.1	1.1
Conditioned reinforcement - inactives	0.9	1.0	2.3	1.5	-0.6	0.6
Conditioned locomotion	0.1	0.1	0.4	0.6	-0.1	-0.1
Patch foraging indifference point 0 sec	0.3	0.4	0.7	0.6	0.3	-0.9
Patch foraging indifference point AUC	0.5	0.6	1.4	-0.0	-0.7	1.2
Delay disc. indifference point, 0s delay	1.2	1.3	3.7	1.9	0.3	-0.0
Delay disc. indifference point, 16s delay	2.8	2.8	6.2	2.5	-1.3	0.7
Delay disc. indifference point, 2s delay	2.2	2.4	4.4	2.1	1.3	-1.1
Delay disc. indifference point, 24s delay	1.9	1.8	3.8	1.9	-0.9	1.0
Delay disc. indifference point, 4s delay	1.8	1.9	5.0	2.2	0.7	-0.4
Delay disc. indifference point, 8s delay	0.9	0.9	2.5	1.6	-0.4	0.1
Indifference point function ln k	0.4	0.6	1.1	-0.2	1.1	-0.8
Indifference point function log k	0.4	0.6	1.1	-0.2	1.1	-0.8
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	0.8	0.0	-0.6
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	0.4	-0.2	0.0
Patch foraging total patch changes 18 sec	1.2	1.6	2.0	1.0	-1.4	1.3
Patch foraging total patch changes 24 sec	1.4	1.7	3.2	-1.8	-0.7	1.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.3	0.6	-0.5	0.4
Patch foraging time to switch 0 sec	0.5	0.8	1.6	-0.8	0.3	-1.3
Patch foraging water rate 0 sec	0.8	1.2	1.6	1.3	-0.9	1.1
Patch foraging water rate 12 sec	0.1	0.2	0.5	0.1	0.0	0.7
Patch foraging water rate 18 sec	2.1	2.9	4.4	-1.1	2.1	-1.7
Patch foraging water rate 24 sec	0.5	0.6	1.0	-0.0	-0.9	1.0
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.3	0.5	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	-0.1	0.1
Distance traveled before self-admin	1.1	1.1	1.9	0.2	1.2	-1.4
Distance traveled after self-admin	0.8	0.9	1.4	0.5	1.1	-1.2
Extensor digitorum longus weight	1.2	4.6	13.1	3.6	0.6	-0.6
Bone: elastic displacement	1.3	1.5	2.0	-0.8	1.3	-1.4
Bone: elastic work	1.6	2.1	3.2	-0.2	1.7	-1.8
Bone: endosteal estimation	0.0	0.1	0.1	0.2	0.1	-0.3
Bone: endosteal perimeter	0.2	0.5	1.4	1.2	-0.2	0.1
Epididymis fat weight	0.6	1.4	2.6	-0.4	1.2	-1.6
Delta time in closed arm before/after self-admin	2.6	2.5	6.8	-2.6	0.9	-0.1
Delta time in open arm before/after self-admin	2.6	2.5	6.5	2.5	-1.0	0.3
Diff in mean of infusions in LGA sessions	0.3	0.3	0.4	-0.4	0.6	-0.6
Delay discount exponential model param	2.7	2.8	8.4	-2.9	0.1	0.1
Extinction: sum of active levers before priming	1.6	1.6	2.0	1.1	-1.3	1.4
Active lever presses in extinction session 6	0.6	0.5	1.3	1.1	0.5	-0.3
Bone: final force	0.0	0.1	0.1	0.3	0.2	-0.2
Bone: final moment	0.2	0.3	0.3	0.5	0.4	-0.6
Food consumed during 24 hour testing period	1.4	1.7	2.9	0.9	-1.7	1.2
Glucose	18.1	27.3	30.8	5.3	-5.5	4.8
Heart weight	0.6	0.9	1.2	-0.7	-1.0	1.1
Delay discount hyperbolic model param	2.7	2.8	8.4	-2.9	-0.0	0.1
Intermittent access intake day 1-15 change	2.1	2.1	3.5	0.8	-1.9	1.5
Intermittent access intake escalation	1.7	1.7	3.3	0.5	-1.8	1.2
Intermittent access intake escalation 2	0.5	0.5	1.5	0.2	-1.2	0.1
Intermitt. access day 1 inactive lever presses	0.7	0.7	1.2	-1.0	0.2	1.1
Intermitt. access day 15 inactive lever presses	2.1	2.3	4.1	0.9	-1.5	2.0
Intermitt. access escalation Index	0.4	0.3	0.7	-0.3	-0.5	0.9
Intermittent access day 1 total infusions	0.4	0.5	0.8	0.4	0.7	-0.9
Intermittent access day 15 total infusions	0.6	0.6	1.3	1.1	-0.7	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.6	-0.6	0.2
Intermittent access total infusions	0.2	0.2	0.6	0.8	-0.1	-0.3
Intermittent access day 1 locomotion	0.4	0.5	1.0	-1.0	0.3	-0.5
Intermittent access day 15 total locomotion	0.8	0.8	1.2	1.1	-0.9	0.6
Intermittent access total locomotion	0.3	0.4	0.5	0.7	-0.7	0.4
Intermittent access standard deviation	0.2	0.3	0.8	-0.9	-0.0	-0.1
Left kidney weight	0.7	2.1	2.5	-1.3	1.6	-1.5
Right kidney weight	1.9	5.2	6.5	-2.0	2.5	-2.3
Cocaine induced anxiety	1.4	1.6	2.1	1.3	-1.4	0.9
Post-drug Anxiety	1.0	1.1	1.3	1.0	-1.1	1.0
Baseline Anxiety	0.1	0.1	0.3	0.5	-0.3	0.1
Tail length	1.5	4.7	6.7	1.3	2.4	-2.6
Length with tail	0.7	2.7	3.8	1.9	1.1	-1.7
Length without tail	0.6	1.4	2.8	1.7	-1.0	0.5
Times rat made contact with spout	2.4	2.7	5.2	0.5	-2.3	1.6
Lifetime Intake	0.3	0.3	0.7	0.8	0.2	-0.5
Liver weight, left	4.3	6.9	8.5	-2.9	2.7	-2.3
Liver weight, right	3.3	5.4	9.7	-3.1	2.1	-1.5
Locomotor activity	0.7	1.1	2.1	1.5	-1.0	0.4
Locomotor testing distance	0.8	1.4	1.7	1.0	1.2	-1.3
Locomotor testing rearing	0.9	1.4	4.0	2.0	-0.4	0.3
Locomotion in novel chamber	0.9	1.1	1.6	-1.3	1.1	-0.6
Locomotion in novel chamber post-restriction	1.7	2.1	2.5	-1.5	-1.3	1.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	0.4
Change in fecal boli incidents, locomotor task	0.9	0.8	1.4	-0.4	-1.2	1.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	-0.8	-0.2	-0.1
Bouts of movement, locomotor time 1	1.5	1.6	3.0	0.2	-1.4	1.7
Total resting periods, locomotor time 1	2.2	2.5	4.7	0.3	-1.6	2.2
Rest time, locomotor task time 1	0.9	1.0	2.0	0.0	-1.0	1.4
Distance moved, locomotor task time 1	1.7	1.9	4.0	0.3	1.2	-2.0
Vertical activity count, locomotor time 1	1.0	1.0	2.6	0.0	0.7	-1.6
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.5	-0.7	-0.5	0.5
Bouts of movement, locomotor time 2	0.3	0.3	0.6	-0.5	0.3	0.8
Total resting periods, locomotor time 2	0.4	0.5	1.3	-0.3	-0.0	1.1
Rest time, locomotor task time 2	0.2	0.3	0.4	-0.5	-0.4	0.6
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.1	0.0	-0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.1	0.1	-0.3
Light reinforcement 1	0.1	0.1	0.2	0.3	0.5	-0.0
Light reinforcement 2	0.9	1.3	2.2	-0.1	1.3	-1.5
Bone: marrow area	0.0	0.0	0.0	0.2	0.1	-0.2
Bone: maximum diameter	2.0	3.6	7.8	2.8	-1.4	1.0
Bone: maximum force	0.2	0.3	0.6	0.2	0.5	-0.8
Bone: maximum moment	0.4	0.7	1.4	0.4	0.8	-1.2
Mean time between licks in bursts	1.5	2.1	3.6	0.2	-1.9	1.6
Mean num. licks in bursts	3.5	4.2	6.5	-1.1	-2.3	2.5
Cd content in liver	0.4	0.4	1.1	-1.0	0.3	-0.3
Co content in liver	0.1	0.2	0.3	0.4	0.0	0.6
Cu content in liver	0.1	0.1	0.2	0.2	-0.1	0.4
Fe content in liver	2.1	2.6	4.0	-0.4	-2.0	1.9
K content in liver	0.9	0.9	1.4	0.7	1.2	-0.8
Mg content in liver	0.6	0.7	1.9	1.4	-0.0	0.2
Mn content in liver	0.8	0.9	1.7	0.3	1.3	-1.0
Na content in liver	3.6	3.8	7.6	2.8	-1.4	1.4
Rb content in liver	0.6	0.8	2.0	1.4	0.2	-0.5
Se content in liver	0.6	0.7	2.0	1.4	0.0	-0.3
Sr content in liver	1.0	0.9	1.4	1.1	-1.2	0.6
Zn content in liver	0.2	0.3	0.5	0.7	-0.0	-0.6
Bone: minimum diameter	0.1	0.1	0.3	-0.2	0.5	-0.3
Time in familiar zone, hab. session 1	0.5	0.5	0.8	-0.9	0.2	-0.7
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.8	0.6	-0.4
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.4	-0.3	0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.2	0.0	-0.2	0.4
Locomotion velocity, hab. session 1	0.5	0.7	1.4	-0.2	-0.8	1.2
Time in familiar zone, hab. session 2	1.8	1.9	5.6	-2.4	0.1	-0.2
Time in novel zone, hab. session 2	1.7	1.7	4.9	2.2	-0.1	-0.3
Total zone transitions, hab. session 2	0.4	0.5	0.6	0.8	-0.6	0.7
Total locomotion distance, hab. session 2	0.9	1.1	1.3	1.1	-1.2	0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.7	1.3	-1.0	0.9
Novel to familiar place preference ratio	2.2	2.3	2.7	1.6	-1.3	1.6
Novelty place preference	2.1	2.2	2.5	1.6	-1.3	1.5
Time in novel zone, NPP test	2.0	2.0	2.2	1.5	-1.3	1.5
Total zone transitions, NPP test	0.2	0.3	0.5	-0.5	0.7	-0.2
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.0	0.2	0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.3	0.2	0.2
Intraocular pressure	0.9	1.3	2.2	0.6	-1.5	1.2
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.2	-0.3	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.2	-0.2	0.3
Parametrial fat weight	1.8	3.5	4.3	1.7	-2.1	1.9
Pavlov. Cond. lever latency	0.4	0.5	0.6	0.6	-0.8	0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.2	-1.1	0.4	-0.2
Pavlov. Cond. change in total contacts	0.6	0.6	1.7	1.3	-0.4	0.3
Pavlov. Cond. index score	0.5	0.6	1.5	-1.2	0.5	-0.2
Pavlov. Cond. latency score	0.5	0.6	1.4	-1.2	0.5	-0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.7	0.2	-0.2
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	1.0	0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	2.0	0.2	1.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.7	-1.3	0.5	-0.2
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.3	0.2	0.2
Pavlov. Cond. lever latency	1.6	2.2	2.6	1.6	1.2	-1.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.1	0.5	-0.5
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	-0.9	-0.3	0.5
Pavlov. Cond. index score	0.5	0.6	1.2	-1.1	-0.4	0.6
Pavlov. Cond. latency score	0.4	0.5	1.3	-1.1	-0.2	0.4
Pavlov. Cond. lever contacts	1.5	2.1	3.0	-1.7	-1.1	1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	-0.1	-0.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	-1.1	-0.1	0.3
Pavlov. Cond. response bias	0.7	1.0	1.0	-1.0	-1.0	1.0
Time in closed arm before self-admin	0.3	0.3	0.8	-0.2	0.5	-0.9
Time in closed arm after self-admin	2.0	2.0	4.8	-2.2	0.9	-0.7
Time in open arm before self-admin	0.1	0.2	0.3	-0.3	-0.1	0.6
Time in open arm after self-admin	1.9	2.1	2.7	1.1	-1.6	1.7
Bone: periosteal estimation	0.3	0.5	1.5	1.2	0.2	-0.3
Bone: periosteal perimeter	0.7	1.1	3.4	1.8	-0.0	0.1
Bone: post-yield work	0.3	0.4	0.8	0.6	-0.0	-0.9
Progressive ratio test 1 active lever presses	0.7	0.7	1.5	1.2	-0.4	0.7
Progressive ratio test 1 breakpoint	0.4	0.4	0.7	0.8	-0.2	0.7
Progressive ratio test 1 inactive lever presses	1.2	1.4	3.8	2.0	0.0	0.5
Progressive ratio test 2 active lever presses	0.5	0.6	1.4	1.2	-0.5	-0.2
Progressive ratio test 2 breakpoint	0.6	0.7	1.6	1.3	-0.7	0.2
Progressive ratio test 2 inactive lever presses	1.6	1.8	2.8	1.7	-1.4	0.9
Incentive Sensitization - Responses	0.5	0.5	1.1	1.0	-0.6	-0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.1	1.0	-0.5	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.2	0.6	0.7	-0.2	0.3
Progressive ratio	0.9	1.0	2.3	0.5	0.7	-1.5
Food seeking constrained by brief footshock	3.2	3.9	5.2	1.9	1.7	-2.3
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.8	0.3	0.4
Retroperitoneal fat weight	0.2	0.6	0.8	-0.1	-0.9	0.9
Reaction time number correct	0.3	0.4	0.8	-0.1	-0.9	0.6
Reaction time mean minus median	0.4	0.5	1.2	-0.1	-1.1	0.5
Reaction time mean minus median AUC	0.1	0.1	0.2	0.1	-0.4	0.2
Reaction time num false alarms	0.3	0.5	0.7	0.6	0.8	-0.6
Reaction time num false alarms AUC	0.8	1.1	1.6	0.4	1.3	-1.2
Reaction time trials correct on left	0.3	0.4	0.8	-0.1	-0.9	0.6
Reaction time trials on left	0.3	0.4	0.8	-0.1	-0.9	0.6
Reaction time mean	0.1	0.1	0.2	-0.4	-0.4	0.0
Reaction time mean AUC	0.1	0.1	0.3	-0.6	-0.1	-0.1
Median of all reaction times	0.1	0.1	0.2	-0.5	-0.1	-0.0
Reaction time omissions	0.2	0.3	0.7	-0.8	0.1	0.4
Reaction time false alarm rate	1.4	1.9	3.1	0.4	1.8	-1.5
Reaction time premature initiation rate	2.1	2.9	6.8	-2.6	1.3	-0.2
Reaction time premature initiations	1.1	1.6	4.3	-2.1	0.5	0.2
Std. dev. reaction times	0.3	0.5	1.1	0.1	-1.1	0.5
Reaction time trials completed	0.3	0.4	0.8	-0.1	-0.9	0.6
Reaction time trials AUC	0.2	0.3	0.6	0.0	-0.8	0.5
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.7	-0.0	-0.5
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.0	-0.1	-0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.1	0.6	-0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	1.0	-0.1	1.0	-0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.5	-0.4	0.6
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.5	-0.1	0.3
Total sessions with >9 infusions	0.1	0.1	0.1	-0.3	0.4	-0.1
Short access day 1 total inactive lever presses	1.2	1.3	2.8	1.7	0.7	-0.8
Short access day 10 total inactive lever presses	0.5	0.6	0.9	-1.0	0.8	0.4
Short access day 1 total infusions	0.7	0.7	1.6	-0.0	1.3	-0.7
Short access day 10 total infusions	0.5	0.5	0.8	-0.3	0.9	-0.8
Short access total infusions	0.9	1.0	1.7	-0.1	1.3	-1.1
Short access day 1 locomotion	2.7	2.9	3.2	-1.6	1.8	-1.7
Short access day 10 total locomotion	0.9	1.0	2.3	-1.5	0.6	-0.6
Short access total locomotion	2.7	2.8	5.4	-2.3	1.4	-1.1
One hour access (0.3 mA shock)	0.2	0.3	0.5	0.7	-0.5	-0.2
Compulsive drug intake	2.0	2.0	5.7	-2.4	0.4	0.2
One hour access (shock baseline)	1.9	2.2	5.7	2.4	-0.9	0.2
Social response proportion	2.1	2.2	4.0	1.0	-2.0	1.4
Social responses	1.9	2.5	4.1	1.1	-2.0	1.4
Social time	0.5	0.7	1.4	-0.5	-1.2	0.5
Soleus weight	1.0	2.9	4.4	1.4	1.6	-2.1
Bone: stiffness	0.1	0.1	0.2	-0.4	-0.0	0.5
Tibialis anterior weight	0.7	2.3	6.6	2.6	-0.2	-0.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.1	0.5	-0.7
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.7	-0.5	0.8	-0.7
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.9	0.1	0.3
Time to tail flick, test, after self-admin	1.2	1.2	2.3	1.5	0.7	-1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.1	-0.0
Delta time to tail flick, test, before/after SA	0.7	0.6	1.7	1.3	-0.2	-0.2
Tibia length	1.2	3.4	5.1	-0.8	2.1	-2.3
Ambulatory time before self-admin	1.9	2.0	3.4	0.3	1.6	-1.9
Ambulatory time after self-admin	0.8	0.9	1.6	0.3	1.0	-1.3
Bone: tissue strength	0.3	0.3	0.9	-0.3	-0.1	-1.0
Total heroin consumption	0.0	0.0	0.1	-0.3	0.1	0.0
Bone: trabecular number	0.8	1.2	2.4	-0.4	1.6	-1.0
Bone: trabecular spacing	0.7	0.9	1.4	1.0	-1.2	0.3
Bone: trabecular thickness	1.8	2.1	3.0	-1.4	1.7	-1.2
Bone: trabecular tissue density	0.4	0.6	1.2	-0.3	-1.1	0.7
Water consumed over 24 hours	0.8	0.9	2.4	0.4	-1.5	0.5
Number of responses in last shaping day	0.2	0.3	0.6	-0.7	0.5	-0.1