Hub : Genes

Hormad2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	alternative TSS	NM_001017501.1	0.3	0.17	2.8e-03	0.04	0.08	0.05	0.05	3.9e-02	5.2e-03	2.9e-02	2.2e-02
2	Liver	gene expression	Hormad2	0.06	0.06	7.2e-03	0.01	0	0	0	2.2e-02	2.7e-01	3.1e-01	1.8e-01
3	Adipose	gene expression	Hormad2	0.13	0.09	1.6e-04	0.02	0.03	0.02	0.02	2.4e-03	5.4e-04	1.6e-03	3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.5	0.9	1.8	0.1	1.3	-0.9
Area under the delay curve	1.8	2.7	8.0	-2.8	-0.3	0.1
BMI with tail	0.3	1.1	1.1	-1.1	-1.0	1.0
BMI without tail	0.1	0.7	1.1	-0.7	0.8	-1.0
Body weight	0.9	4.0	11.9	-3.4	0.1	-0.3
Weight adjusted by age	0.5	1.3	3.1	-1.8	0.8	-0.6
Bone surface	0.1	0.2	0.4	-0.6	0.6	-0.2
Bone volume	0.2	0.4	0.7	-0.3	0.8	-0.6
Breakpoint value in progressive ratio session	0.0	0.1	0.1	-0.4	-0.3	0.2
Number of licking bursts	0.4	1.1	2.1	-0.9	0.7	-1.4
Context. condit. distance diff. score	0.5	0.6	1.6	1.3	-0.1	0.5
Locomotion velocity, session 1	3.0	3.4	4.9	1.2	-1.9	2.2
Locomotion distance, session 1	0.2	0.3	0.6	0.4	0.7	0.2
Locomotion velocity, session 2	3.0	3.6	4.3	1.8	-2.1	1.8
Locomotion distance, session 2	1.7	2.4	4.7	2.2	-0.8	1.3
Locomotion velocity, session 3	0.1	0.1	0.2	0.3	0.5	0.4
Locomotion distance, session 3	0.3	0.3	0.6	-0.4	-0.5	0.7
Stereotopy head waving bouts, day 3	0.3	0.4	1.0	1.0	0.1	0.2
Stereotopy head waving duration, day 3	0.8	1.0	2.3	1.5	-0.3	0.8
Locomotion velocity, session 7	0.3	0.3	0.6	0.0	-0.6	0.8
Locomotion distance, session 7	0.6	0.7	1.5	0.6	-0.6	1.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.7	0.2	-0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.7	-0.8	0.6	-0.4
Locomotion velocity, session 8	2.8	3.4	5.9	2.4	-1.6	1.4
Locomotion distance, session 8	2.4	3.5	9.7	3.1	-0.2	0.9
Degree of sensitization distance	1.5	1.6	4.4	2.1	-0.4	0.5
Degree of sensitization stereotypy	0.5	0.5	0.9	-1.0	0.6	-0.6
Conditioned locomotion	0.5	0.5	1.1	-0.4	1.0	-0.6
Cocaine response after cond. corrected	0.5	0.7	1.9	-1.4	0.3	-0.2
Cocaine response after cond. not corrected	1.4	2.0	5.2	-2.3	0.7	-0.5
Cocaine response before conditioning	0.2	0.3	0.6	-0.8	0.4	-0.1
Saline control response	0.8	1.2	2.2	1.0	-0.6	1.5
Bone: connectivity density	0.3	0.5	1.3	-0.2	1.1	-0.3
Bone: cortical apparent density	0.1	0.1	0.3	-0.1	0.1	-0.5
Bone: cortical area	1.1	1.7	4.8	-2.2	0.5	-0.4
Bone: cortical porosity	0.5	0.6	1.0	-1.0	0.7	-0.4
Bone: cortical porosity	0.5	0.5	0.8	-0.7	0.9	-0.5
Bone: cortical thickness	1.6	2.6	5.4	-2.3	1.2	-1.0
Bone: cortical thickness	1.4	1.8	3.7	-0.6	1.9	-1.1
Bone: cortical tissue density	0.0	0.1	0.2	-0.1	0.0	-0.5
Condit. Reinf. active minus inactive responses	2.0	2.3	4.6	0.3	-1.5	2.1
Condit. Reinf. active-inactive response ratio	5.2	5.6	7.9	1.6	-2.5	2.8
Condit. Reinf. active responses	0.9	1.2	2.4	0.3	-1.0	1.6
Condit. Reinf. inactive responses	0.6	0.8	0.9	-0.8	1.0	-0.9
Incentive salience index mean	1.2	1.6	3.0	-0.4	-1.2	1.7
Condit. Reinf. lever presses	0.3	0.5	1.1	-1.0	-0.2	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	0.9	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.1	-0.1	0.6
Condit. Reinf. active responses	0.7	1.0	2.3	1.5	-0.1	0.9
Condit. Reinf. inactive responses	0.9	1.3	3.1	1.8	-0.2	0.8
Condit. Reinf. lever presses	0.1	0.2	0.3	0.6	0.3	0.4
Condit. Reinf. lever reinforcers received	0.6	0.8	1.4	1.2	-0.0	1.0
Conditioned reinforcement - actives	0.2	0.9	2.0	-1.4	-0.7	0.4
Conditioned reinforcement - inactives	0.4	1.2	3.0	-1.7	-0.7	0.3
Conditioned locomotion	0.5	0.7	2.0	-1.4	-0.1	-0.4
Patch foraging indifference point 0 sec	0.1	0.2	0.7	-0.0	0.3	-0.8
Patch foraging indifference point AUC	0.3	0.6	0.8	0.8	-0.6	0.9
Delay disc. indifference point, 0s delay	2.8	3.2	9.2	-3.0	0.4	-0.3
Delay disc. indifference point, 16s delay	1.0	1.5	2.3	-1.5	-1.3	0.7
Delay disc. indifference point, 2s delay	4.0	4.4	10.6	-3.3	1.3	-1.1
Delay disc. indifference point, 24s delay	1.2	1.9	4.2	-2.0	-0.8	0.9
Delay disc. indifference point, 4s delay	2.2	2.4	6.5	-2.6	0.6	-0.4
Delay disc. indifference point, 8s delay	0.2	0.3	0.8	-0.9	-0.4	0.2
Indifference point function ln k	0.2	0.6	0.9	-0.8	1.0	-0.6
Indifference point function log k	0.2	0.6	0.9	-0.8	1.0	-0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	0.0	0.0	-0.6
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	-0.2	0.1	-0.3
Patch foraging total patch changes 18 sec	0.4	1.0	1.7	0.4	-1.3	1.0
Patch foraging total patch changes 24 sec	0.5	1.8	4.3	2.1	-0.5	0.8
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.1	-0.3	0.1
Patch foraging time to switch 0 sec	0.1	0.5	1.3	0.3	0.5	-1.1
Patch foraging water rate 0 sec	0.2	0.7	1.3	-0.4	-0.8	1.1
Patch foraging water rate 12 sec	0.1	0.2	0.7	-0.2	0.1	0.8
Patch foraging water rate 18 sec	1.1	2.5	4.7	-0.2	2.2	-1.7
Patch foraging water rate 24 sec	0.4	0.6	0.8	0.7	-0.7	0.9
Patch foraging water rate 6 sec	0.1	0.2	0.4	-0.2	0.6	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.6	-0.1	0.0
Distance traveled before self-admin	0.6	1.4	2.7	0.1	1.2	-1.6
Distance traveled after self-admin	1.4	2.4	3.5	-0.7	1.9	-1.9
Extensor digitorum longus weight	1.1	4.5	12.2	-3.5	0.8	-0.9
Bone: elastic displacement	0.9	1.2	2.2	0.0	1.2	-1.5
Bone: elastic work	2.0	2.6	3.8	-0.9	1.8	-2.0
Bone: endosteal estimation	0.0	0.1	0.2	0.3	0.1	-0.5
Bone: endosteal perimeter	0.1	0.2	0.4	-0.7	-0.2	-0.0
Epididymis fat weight	0.3	1.6	3.9	-2.0	0.5	-0.9
Delta time in closed arm before/after self-admin	0.4	0.3	0.6	0.8	0.6	0.2
Delta time in open arm before/after self-admin	0.5	0.6	1.0	-1.0	-1.0	0.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.2	0.4	-0.4
Delay discount exponential model param	1.9	2.6	7.8	2.8	0.2	-0.1
Extinction: sum of active levers before priming	0.7	1.1	1.4	-0.6	-1.2	1.2
Active lever presses in extinction session 6	0.8	0.8	1.8	-1.3	0.6	-0.5
Bone: final force	0.1	0.1	0.2	-0.1	0.3	-0.5
Bone: final moment	0.2	0.4	0.8	-0.3	0.5	-0.9
Food consumed during 24 hour testing period	0.9	1.8	2.8	1.0	-1.7	1.3
Glucose	13.1	20.8	36.3	-0.4	-6.0	5.1
Heart weight	1.0	1.6	2.5	-0.4	-1.4	1.6
Delay discount hyperbolic model param	2.2	2.9	8.6	2.9	0.0	0.1
Intermittent access intake day 1-15 change	0.3	1.7	3.6	-0.2	-1.9	1.2
Intermittent access intake escalation	0.3	1.6	2.9	-0.7	-1.7	1.2
Intermittent access intake escalation 2	0.1	0.2	0.7	-0.1	-0.8	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.2	-1.1	0.3	0.9
Intermitt. access day 15 inactive lever presses	0.4	2.1	4.2	-0.5	-1.4	2.1
Intermitt. access escalation Index	0.8	2.4	3.7	1.2	-1.5	1.9
Intermittent access day 1 total infusions	0.5	1.6	2.5	-1.6	1.0	-1.2
Intermittent access day 15 total infusions	0.4	1.0	2.8	-1.7	-0.6	0.0
Intermittent access terminal intake (last 3 days)	0.3	0.6	1.6	-1.3	-0.2	-0.3
Intermittent access total infusions	0.8	1.0	2.6	-1.6	0.0	-0.5
Intermittent access day 1 locomotion	0.4	0.7	1.4	0.1	0.8	-1.2
Intermittent access day 15 total locomotion	0.3	1.2	3.4	-1.8	-0.5	-0.0
Intermittent access total locomotion	0.6	0.7	1.9	-1.4	-0.4	-0.0
Intermittent access standard deviation	0.1	0.3	0.5	-0.4	0.6	-0.7
Left kidney weight	0.4	3.0	3.7	-1.9	1.9	-1.4
Right kidney weight	1.2	8.2	10.5	-2.5	3.2	-2.8
Cocaine induced anxiety	0.3	0.8	1.3	-0.9	-1.2	0.6
Post-drug Anxiety	0.9	1.0	1.4	-1.2	-1.0	0.7
Baseline Anxiety	0.0	0.0	0.1	-0.2	-0.1	0.3
Tail length	0.9	5.0	5.7	-2.4	1.9	-2.4
Length with tail	1.2	5.3	9.2	-3.0	1.6	-2.0
Length without tail	0.3	1.5	4.5	-2.1	0.1	-0.3
Times rat made contact with spout	3.3	3.8	4.9	1.9	-2.2	1.8
Lifetime Intake	0.9	1.1	2.5	-1.6	0.3	-0.8
Liver weight, left	0.7	1.3	2.6	-0.5	1.6	-1.0
Liver weight, right	0.3	0.6	1.1	0.3	1.0	-0.7
Locomotor activity	0.4	0.6	1.3	0.4	-1.1	0.5
Locomotor testing distance	0.6	1.4	1.8	-1.4	1.0	-1.1
Locomotor testing rearing	0.2	0.6	1.8	-1.3	-0.2	0.1
Locomotion in novel chamber	0.5	0.7	1.4	-0.2	1.2	-0.8
Locomotion in novel chamber post-restriction	0.9	2.6	3.3	1.8	-1.3	1.7
Fecal boli incidents, locomotor time 1	0.1	0.3	0.4	0.6	-0.4	0.5
Change in fecal boli incidents, locomotor task	1.6	1.7	1.8	1.4	-1.3	1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.4	-0.0
Bouts of movement, locomotor time 1	1.1	1.4	2.5	0.0	-1.3	1.6
Total resting periods, locomotor time 1	1.8	2.1	4.0	-0.0	-1.5	2.0
Rest time, locomotor task time 1	0.4	0.7	1.2	0.5	-0.7	1.1
Distance moved, locomotor task time 1	0.5	1.4	3.2	-0.0	1.0	-1.8
Vertical activity count, locomotor time 1	0.2	1.1	2.4	0.7	0.5	-1.5
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.5	0.7	-0.6	0.5
Bouts of movement, locomotor time 2	0.2	0.5	0.8	-0.8	0.1	0.9
Total resting periods, locomotor time 2	0.2	0.7	1.5	-0.8	-0.2	1.2
Rest time, locomotor task time 2	0.3	0.5	0.8	0.9	-0.4	0.7
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.1	0.2	-0.5
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.3	0.3	-0.6
Light reinforcement 1	0.2	0.7	1.7	-1.3	0.7	-0.1
Light reinforcement 2	0.5	1.1	2.1	-0.2	1.1	-1.5
Bone: marrow area	0.0	0.1	0.2	0.3	0.1	-0.4
Bone: maximum diameter	0.8	1.7	2.6	-1.6	-1.3	0.9
Bone: maximum force	0.2	0.5	0.9	-0.1	0.7	-1.0
Bone: maximum moment	0.5	1.0	1.9	-0.3	1.0	-1.4
Mean time between licks in bursts	0.4	2.4	2.9	1.4	-1.7	1.5
Mean num. licks in bursts	1.8	5.0	6.3	2.1	-2.1	2.5
Cd content in liver	0.4	0.4	0.9	0.1	-1.0	0.5
Co content in liver	0.5	0.6	1.6	-1.3	0.5	-0.2
Cu content in liver	0.2	0.3	0.5	-0.5	-0.3	0.7
Fe content in liver	0.9	1.1	2.1	0.9	-0.6	1.5
K content in liver	3.5	3.4	8.5	-2.9	1.1	-0.7
Mg content in liver	1.9	2.1	6.2	-2.5	0.2	0.0
Mn content in liver	0.4	0.4	0.4	-0.6	0.6	-0.6
Na content in liver	2.0	2.2	4.1	-2.0	-0.9	1.3
Rb content in liver	0.4	0.4	0.7	-0.8	0.3	-0.7
Se content in liver	1.7	2.0	5.5	-2.3	0.5	-0.6
Sr content in liver	0.6	0.5	1.0	-0.5	-1.0	0.4
Zn content in liver	0.3	0.3	0.4	-0.6	0.5	-0.5
Bone: minimum diameter	0.1	0.1	0.3	-0.0	0.5	-0.3
Time in familiar zone, hab. session 1	0.9	1.0	2.3	1.5	0.4	-0.8
Time in novel zone, hab. session 1	0.6	0.7	1.8	-1.3	0.4	-0.4
Total zone transitions, hab. session 1	0.5	0.8	1.8	1.3	-0.4	0.5
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.2	-0.2	0.4
Locomotion velocity, hab. session 1	0.5	0.8	1.5	0.4	-0.8	1.2
Time in familiar zone, hab. session 2	0.9	1.0	2.8	1.7	0.3	-0.2
Time in novel zone, hab. session 2	0.4	0.5	1.3	-1.1	-0.2	-0.2
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.2	-0.7	0.9
Total locomotion distance, hab. session 2	0.6	0.8	1.4	0.2	-1.2	1.0
Locomotion velocity, hab. session 2	0.5	0.7	1.1	-0.2	-1.1	1.0
Novel to familiar place preference ratio	1.2	1.5	2.2	-0.6	-1.4	1.5
Novelty place preference	1.1	1.5	2.1	-0.6	-1.4	1.4
Time in novel zone, NPP test	1.1	1.3	1.9	-0.5	-1.3	1.4
Total zone transitions, NPP test	0.2	0.3	0.7	-0.4	0.8	-0.0
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.5	0.3	0.2
Locomotion velocity, NPP test	0.2	0.2	0.6	-0.8	0.3	0.3
Intraocular pressure	1.1	1.8	2.6	1.2	-1.6	1.2
Delta distance traveled before/after self-admin	0.2	0.3	0.6	-0.8	0.4	0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.4	0.4	-0.0
Parametrial fat weight	3.3	7.7	12.3	1.0	-3.5	3.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.1	-0.4	0.3
Pavlov. Cond. magazine entry latency	0.5	0.6	1.9	1.4	0.2	-0.0
Pavlov. Cond. change in total contacts	0.1	0.2	0.2	-0.3	-0.5	0.4
Pavlov. Cond. index score	0.2	0.3	0.7	0.8	0.4	-0.1
Pavlov. Cond. latency score	0.3	0.3	0.7	0.8	0.5	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.4	-0.2
Pavlov. Cond. magazine entry number	0.5	0.6	1.5	-1.2	0.2	-0.6
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.1	-1.7	1.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.8	0.5	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	0.3	0.2
Pavlov. Cond. lever latency	2.5	3.5	5.9	-2.4	1.4	-1.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	0.3	-0.4
Pavlov. Cond. change in total contacts	0.4	1.0	2.2	1.5	-0.5	0.7
Pavlov. Cond. index score	0.6	1.0	2.2	1.5	-0.5	0.7
Pavlov. Cond. latency score	0.5	0.8	2.1	1.5	-0.3	0.5
Pavlov. Cond. lever contacts	1.9	2.9	5.1	2.2	-1.1	1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	-0.9	0.4	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.6	-0.4	-0.3	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.3	1.5	-0.4	0.5
Pavlov. Cond. response bias	1.3	1.8	3.3	1.8	-1.0	1.1
Time in closed arm before self-admin	0.4	0.8	1.3	0.3	0.9	-1.2
Time in closed arm after self-admin	0.6	0.6	1.2	0.5	1.1	-0.7
Time in open arm before self-admin	0.0	0.0	0.1	-0.3	-0.0	0.2
Time in open arm after self-admin	1.2	1.3	2.5	-0.1	-1.6	1.2
Bone: periosteal estimation	0.2	0.4	0.9	-0.9	0.4	-0.5
Bone: periosteal perimeter	0.6	1.1	3.3	-1.8	0.0	0.1
Bone: post-yield work	0.2	0.3	0.5	0.6	-0.0	-0.7
Progressive ratio test 1 active lever presses	0.5	0.9	2.7	-1.6	0.1	-0.0
Progressive ratio test 1 breakpoint	0.5	0.9	2.8	-1.7	0.0	0.1
Progressive ratio test 1 inactive lever presses	0.4	0.9	2.6	-1.6	-0.2	0.4
Progressive ratio test 2 active lever presses	0.3	0.4	0.9	-1.0	-0.6	-0.2
Progressive ratio test 2 breakpoint	0.3	0.4	0.7	-0.9	-0.6	-0.1
Progressive ratio test 2 inactive lever presses	0.4	1.3	1.7	-1.3	-1.3	0.8
Incentive Sensitization - Responses	0.1	0.2	0.5	-0.1	-0.7	-0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.5	-0.0	-0.7	-0.3
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.5	-1.2	0.2	0.0
Progressive ratio	0.3	0.8	1.8	0.1	0.8	-1.3
Food seeking constrained by brief footshock	3.4	4.2	5.5	-2.1	1.6	-2.3
Seeking ratio, punishment vs. effort	0.3	0.7	2.0	-1.4	0.4	0.3
Retroperitoneal fat weight	0.9	4.2	6.2	0.4	-2.5	2.5
Reaction time number correct	0.3	1.0	2.0	1.4	-0.9	0.6
Reaction time mean minus median	0.1	0.7	1.6	0.5	-1.3	0.6
Reaction time mean minus median AUC	0.0	0.2	0.4	-0.4	-0.6	0.3
Reaction time num false alarms	0.6	1.1	1.8	-1.3	0.8	-0.9
Reaction time num false alarms AUC	0.8	1.8	2.1	-1.3	1.3	-1.5
Reaction time trials correct on left	0.3	1.0	2.0	1.4	-0.9	0.6
Reaction time trials on left	0.3	1.0	2.0	1.4	-0.8	0.6
Reaction time mean	0.0	0.1	0.3	0.1	-0.5	0.0
Reaction time mean AUC	0.0	0.0	0.1	-0.0	-0.3	-0.1
Median of all reaction times	0.0	0.0	0.0	0.0	-0.2	-0.1
Reaction time omissions	0.0	0.1	0.1	0.2	-0.0	0.4
Reaction time false alarm rate	2.4	3.4	4.2	-2.1	1.7	-1.7
Reaction time premature initiation rate	0.6	0.9	1.6	1.0	1.2	-0.2
Reaction time premature initiations	0.3	0.9	2.5	1.6	0.5	0.2
Std. dev. reaction times	0.2	0.6	1.5	0.5	-1.2	0.4
Reaction time trials completed	0.3	1.0	2.0	1.4	-0.8	0.6
Reaction time trials AUC	0.2	0.8	1.5	1.2	-0.7	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.5	-0.1	-0.0
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.0	-0.1	-0.4
Latency to leave start box in cocaine runway	0.2	0.3	0.4	-0.6	0.6	-0.4
Latency to leave start box in cocaine runway, F	0.9	1.1	1.3	-1.0	1.1	-1.0
Latency to leave start box in cocaine runway, M	0.3	0.2	0.6	0.0	-0.4	0.8
Std. dev. time between licks in bursts	0.3	0.5	1.4	1.2	-0.1	0.5
Total sessions with >9 infusions	0.7	0.8	1.6	-0.4	1.3	-0.9
Short access day 1 total inactive lever presses	0.4	0.9	2.0	-1.4	0.4	-0.7
Short access day 10 total inactive lever presses	0.1	0.3	0.5	-0.7	0.7	0.3
Short access day 1 total infusions	0.6	1.2	2.3	-0.6	1.5	-1.0
Short access day 10 total infusions	0.3	0.6	0.9	-0.0	0.9	-1.0
Short access total infusions	0.7	1.0	1.3	-0.7	1.1	-1.1
Short access day 1 locomotion	1.5	2.6	4.1	0.3	1.9	-2.0
Short access day 10 total locomotion	0.4	1.6	1.7	1.3	1.3	-1.3
Short access total locomotion	1.2	1.8	2.5	1.1	1.6	-1.3
One hour access (0.3 mA shock)	0.3	0.3	0.5	-0.7	-0.6	-0.2
Compulsive drug intake	0.3	0.4	0.9	1.0	0.4	0.2
One hour access (shock baseline)	0.4	1.1	2.7	-1.6	-0.8	-0.0
Social response proportion	1.6	2.0	3.4	1.2	-1.8	1.1
Social responses	1.6	2.1	3.7	0.9	-1.9	1.4
Social time	0.7	1.1	2.2	1.5	-0.9	0.4
Soleus weight	1.4	4.1	5.9	-1.7	1.9	-2.4
Bone: stiffness	0.0	0.1	0.2	-0.0	-0.0	0.5
Tibialis anterior weight	0.4	1.4	3.9	-2.0	0.1	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.9	-0.0	0.6	-0.9
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	-0.1	0.4	0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.1	0.5	-0.2
Time to tail flick, test, after self-admin	0.5	0.6	1.2	-1.1	0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.3	0.7	0.2	-0.3	0.8
Delta time to tail flick, test, before/after SA	0.2	0.3	0.6	-0.2	-0.8	0.4
Tibia length	1.2	3.4	5.4	-0.6	2.1	-2.3
Ambulatory time before self-admin	0.6	1.8	3.5	-0.2	1.3	-1.9
Ambulatory time after self-admin	1.1	1.8	2.9	-0.3	1.6	-1.7
Bone: tissue strength	0.6	0.6	1.2	1.1	0.1	-0.8
Total heroin consumption	0.1	0.1	0.1	0.3	0.2	-0.2
Bone: trabecular number	0.7	1.4	2.5	-0.6	1.6	-1.1
Bone: trabecular spacing	0.2	0.4	0.9	0.3	-1.0	0.2
Bone: trabecular thickness	0.8	1.1	2.2	-0.1	1.5	-1.1
Bone: trabecular tissue density	0.5	1.0	1.3	1.0	-1.2	0.7
Water consumed over 24 hours	1.3	2.6	5.4	2.3	-1.5	0.4
Number of responses in last shaping day	0.2	0.2	0.6	0.0	-0.1	0.8