Hub : Genes

Hhip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Hhip	0.07	0.04	2.0e-07	0.1	0.08	0.08	0.07	3.6e-08	3.2e-07	4.9e-07	1.6e-06
2	BLA	gene expression	Hhip	0.08	0.04	3.3e-04	0.09	0.08	0.08	0.08	2.6e-05	7.6e-05	5.7e-05	4.8e-05
3	Brain	gene expression	Hhip	0.18	0.07	5.6e-17	0.18	0.19	0.18	0.19	9.1e-17	1.2e-17	7.5e-17	3.1e-17
4	NAcc	gene expression	Hhip	0.05	0.03	6.3e-09	0.07	0.06	0.07	0.06	2.0e-10	1.3e-09	8.8e-11	5.5e-10
5	Adipose	gene expression	Hhip	0.09	0.05	2.3e-07	0.04	0.04	0.06	0.04	1.6e-05	1.2e-05	1.7e-07	4.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.3	2.3	5.0	2.2	1.8	1.4	1.3	0.0
Area under the delay curve	0.2	0.2	0.4	-0.5	-0.3	-0.4	-0.5	0.6
BMI with tail	2.6	8.8	13.1	-3.1	-3.0	-2.7	-3.6	2.2
BMI without tail	0.1	0.4	1.3	-0.3	1.1	0.7	0.4	0.2
Body weight	0.4	1.6	3.5	1.9	1.6	0.6	1.2	-0.6
Weight adjusted by age	0.6	0.9	1.4	-0.6	-1.2	-1.1	-1.2	-0.2
Bone surface	1.1	2.1	4.2	2.0	1.6	1.3	1.3	-0.2
Bone volume	2.1	3.8	8.5	2.9	2.2	1.6	1.7	-0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.1	0.4	0.6	0.4	-0.7
Number of licking bursts	0.3	0.5	0.7	0.5	0.7	0.4	0.9	-0.8
Context. condit. distance diff. score	0.3	0.3	1.1	0.6	-0.2	-1.0	0.0	0.2
Locomotion velocity, session 1	0.2	0.3	0.7	0.3	-0.5	-0.3	0.4	-0.9
Locomotion distance, session 1	0.1	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.3
Locomotion velocity, session 2	0.1	0.1	0.3	0.5	0.1	0.2	0.4	-0.3
Locomotion distance, session 2	0.2	0.2	0.6	0.8	0.2	0.0	0.4	-0.6
Locomotion velocity, session 3	0.2	0.3	0.5	0.5	0.4	0.2	0.6	0.7
Locomotion distance, session 3	0.6	0.6	0.9	0.9	0.8	1.0	0.8	0.5
Stereotopy head waving bouts, day 3	0.8	0.9	2.7	-0.9	-0.6	-0.3	-0.8	1.6
Stereotopy head waving duration, day 3	1.2	1.4	1.9	-1.2	-1.4	-1.2	-1.2	1.1
Locomotion velocity, session 7	0.2	0.2	0.4	0.6	0.7	0.5	0.3	0.2
Locomotion distance, session 7	0.2	0.2	0.6	0.8	0.6	0.3	0.4	-0.0
Stereotopy head waving bouts, day 7	1.5	1.7	4.5	-0.7	1.3	2.1	0.4	1.1
Stereotopy head waving duration, day 7	1.0	1.2	3.1	-0.4	1.2	1.8	0.5	0.9
Locomotion velocity, session 8	0.2	0.2	0.5	0.0	-0.6	-0.7	-0.1	-0.2
Locomotion distance, session 8	0.3	0.4	1.3	0.5	-0.5	-1.1	-0.2	0.4
Degree of sensitization distance	0.3	0.3	0.6	0.1	-0.3	-0.8	-0.3	-0.7
Degree of sensitization stereotypy	1.5	1.6	4.5	-0.2	1.7	2.1	0.9	0.4
Conditioned locomotion	0.8	1.0	2.9	0.9	0.3	0.0	1.0	-1.7
Cocaine response after cond. corrected	0.7	0.8	2.7	1.6	0.2	-1.0	0.5	-0.2
Cocaine response after cond. not corrected	0.5	0.6	2.0	1.4	-0.0	-1.0	0.3	-0.2
Cocaine response before conditioning	0.3	0.4	0.6	-0.8	-0.4	0.7	-0.7	0.6
Saline control response	1.9	2.5	4.1	1.9	1.2	0.7	1.7	-2.0
Bone: connectivity density	0.5	0.7	1.4	1.0	1.2	1.0	0.5	0.2
Bone: cortical apparent density	0.2	0.3	0.5	-0.6	-0.5	-0.3	-0.7	0.6
Bone: cortical area	0.8	1.2	3.5	1.4	0.3	-0.1	0.8	-1.9
Bone: cortical porosity	0.3	0.4	0.8	0.7	0.2	0.5	0.4	-0.9
Bone: cortical porosity	1.2	1.3	2.1	1.1	0.9	1.1	1.1	-1.5
Bone: cortical thickness	0.4	0.6	1.2	-0.6	-1.1	-0.8	-0.7	-0.5
Bone: cortical thickness	0.3	0.3	0.5	-0.7	-0.2	-0.7	-0.4	-0.6
Bone: cortical tissue density	0.1	0.2	0.3	-0.4	-0.3	-0.2	-0.5	0.5
Condit. Reinf. active minus inactive responses	1.1	1.2	2.5	0.2	1.2	1.6	1.2	-0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.0	0.2	0.6	0.6	1.1	-1.4
Condit. Reinf. active responses	1.7	2.1	4.4	0.8	1.8	2.1	1.4	-0.5
Condit. Reinf. inactive responses	1.9	2.3	5.0	1.3	1.9	2.2	1.2	0.1
Incentive salience index mean	1.8	2.2	4.9	0.6	1.7	2.2	1.5	-0.7
Condit. Reinf. lever presses	1.4	2.0	5.3	0.4	1.7	2.3	1.2	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.4	-0.3	0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.3	1.1	-0.2	-0.4	0.4	0.7
Condit. Reinf. active responses	0.1	0.2	0.6	0.0	-0.2	0.1	0.6	-0.8
Condit. Reinf. inactive responses	0.5	0.7	2.8	-0.5	-0.1	0.1	0.4	-1.7
Condit. Reinf. lever presses	0.9	1.2	2.7	-1.6	-1.3	-0.8	-1.0	-0.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.3	-0.6	-0.2	0.1	-0.6
Conditioned reinforcement - actives	0.0	0.1	0.3	0.2	0.5	-0.2	-0.2	0.1
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.6	0.5
Conditioned locomotion	0.6	0.8	2.2	0.2	1.1	0.6	0.7	-1.5
Patch foraging indifference point 0 sec	0.4	0.7	0.9	0.5	0.9	0.9	0.9	-0.8
Patch foraging indifference point AUC	0.0	0.1	0.1	-0.2	0.0	0.3	-0.3	0.2
Delay disc. indifference point, 0s delay	0.6	0.6	0.8	-0.8	-0.8	-0.9	-0.9	0.6
Delay disc. indifference point, 16s delay	0.8	0.9	1.3	-1.0	-1.0	-1.0	-1.2	0.5
Delay disc. indifference point, 2s delay	0.7	0.7	1.1	-1.0	-0.5	-0.6	-1.0	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.1	0.2	-0.3	0.1	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.3	-0.4	0.1	0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.1	-0.0
Indifference point function ln k	0.2	0.3	1.3	0.3	0.2	-0.2	0.1	1.2
Indifference point function log k	0.2	0.3	1.3	0.3	0.2	-0.2	0.1	1.2
Patch foraging total patch changes 0 sec	0.4	0.8	1.1	0.6	1.0	0.9	1.1	-0.9
Patch foraging total patch changes 12 sec	0.6	0.8	1.8	-0.1	0.8	1.4	0.9	-0.9
Patch foraging total patch changes 18 sec	1.3	2.1	3.4	1.0	1.4	1.9	1.8	-0.8
Patch foraging total patch changes 24 sec	0.9	1.6	3.1	0.7	1.3	1.8	1.3	-1.1
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	0.1	0.4	0.5	0.0	0.0
Patch foraging time to switch 0 sec	0.2	0.4	1.4	-0.2	-0.2	0.1	0.7	-1.2
Patch foraging water rate 0 sec	0.2	0.3	0.7	0.8	0.8	0.5	0.2	-0.1
Patch foraging water rate 12 sec	1.1	2.3	7.0	-1.0	-0.7	-1.0	-1.4	2.6
Patch foraging water rate 18 sec	0.3	0.4	1.2	-0.0	0.8	0.5	0.1	1.1
Patch foraging water rate 24 sec	0.5	0.7	1.7	-0.6	-0.6	-0.8	-0.7	1.3
Patch foraging water rate 6 sec	0.5	0.7	1.7	0.4	1.0	1.3	0.6	0.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.8	-0.2	-0.9	-0.7	-0.4	0.5
Distance traveled before self-admin	0.8	1.1	1.6	-1.3	-0.7	-0.8	-1.2	1.2
Distance traveled after self-admin	0.2	0.2	0.5	0.4	0.7	0.3	0.3	0.4
Extensor digitorum longus weight	0.2	1.0	2.5	-1.6	-0.9	0.4	-1.1	0.4
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1	0.3
Bone: elastic work	0.1	0.1	0.4	-0.1	-0.1	-0.0	0.1	-0.6
Bone: endosteal estimation	1.4	3.0	4.7	2.0	1.6	0.9	1.7	-2.2
Bone: endosteal perimeter	2.7	5.7	12.5	3.5	1.7	0.5	2.3	-2.7
Epididymis fat weight	2.0	6.8	11.1	2.9	3.3	2.0	2.8	-1.7
Delta time in closed arm before/after self-admin	0.6	0.6	1.0	0.4	0.8	1.0	0.9	0.3
Delta time in open arm before/after self-admin	0.3	0.3	1.1	-0.1	-0.2	-0.6	0.0	-1.1
Diff in mean of infusions in LGA sessions	0.4	0.5	0.9	-0.4	-0.9	-0.9	-0.7	0.5
Delay discount exponential model param	0.1	0.1	0.2	0.3	0.1	0.4	0.4	-0.5
Extinction: sum of active levers before priming	1.8	2.0	3.7	-1.9	-0.7	-0.4	-1.5	1.8
Active lever presses in extinction session 6	7.1	7.1	9.1	-2.4	-2.7	-2.5	-3.0	2.7
Bone: final force	0.2	0.4	1.3	0.4	0.6	0.3	0.3	-1.1
Bone: final moment	0.3	0.5	1.2	0.5	0.7	0.5	0.4	-1.1
Food consumed during 24 hour testing period	2.1	2.9	4.0	1.2	2.0	1.9	1.6	-1.7
Glucose	0.5	0.9	3.0	0.6	0.5	0.2	0.8	-1.7
Heart weight	0.8	1.2	5.3	-0.7	-0.1	-0.1	-0.6	2.3
Delay discount hyperbolic model param	0.1	0.1	0.3	0.3	0.0	0.3	0.4	-0.5
Intermittent access intake day 1-15 change	0.4	0.8	2.2	0.0	1.5	1.0	0.6	-0.8
Intermittent access intake escalation	0.2	0.5	1.2	-0.4	1.1	0.8	0.3	-0.7
Intermittent access intake escalation 2	0.5	0.5	1.1	-0.1	1.1	0.8	0.5	-0.8
Intermitt. access day 1 inactive lever presses	0.1	0.3	1.3	1.1	0.1	-0.6	0.1	0.1
Intermitt. access day 15 inactive lever presses	0.5	1.0	1.5	-0.3	-1.2	-1.1	-1.0	-1.1
Intermitt. access escalation Index	0.5	0.6	1.3	0.9	0.9	0.5	1.1	0.2
Intermittent access day 1 total infusions	0.3	0.6	1.5	-0.5	-0.8	-1.2	-0.6	-0.0
Intermittent access day 15 total infusions	0.2	0.3	0.9	-1.0	-0.1	-0.6	-0.5	-0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	0.2	-0.4	-0.2	0.2
Intermittent access total infusions	0.1	0.1	0.4	-0.2	-0.1	-0.6	-0.3	-0.1
Intermittent access day 1 locomotion	0.6	0.8	1.4	-0.5	-1.1	-1.2	-1.0	0.4
Intermittent access day 15 total locomotion	0.2	0.3	1.3	0.1	1.1	0.1	0.4	-0.2
Intermittent access total locomotion	0.3	0.4	1.0	-0.6	-0.2	-1.0	-0.7	0.1
Intermittent access standard deviation	0.2	0.5	1.2	0.7	1.1	0.7	0.4	-0.5
Left kidney weight	0.2	1.1	1.8	0.7	1.3	1.2	1.1	-0.9
Right kidney weight	0.8	3.9	5.1	1.4	2.3	2.2	2.0	-1.9
Cocaine induced anxiety	0.3	0.4	0.7	-0.2	-0.8	-0.3	-0.7	0.8
Post-drug Anxiety	0.1	0.1	0.2	0.2	0.0	0.4	-0.1	0.4
Baseline Anxiety	0.5	0.5	1.1	0.7	1.1	0.7	0.6	0.4
Tail length	5.2	20.1	28.6	4.9	5.3	4.0	5.2	-2.4
Length with tail	4.1	17.8	28.1	5.3	4.8	3.3	4.7	-2.1
Length without tail	0.4	1.3	4.2	2.0	0.8	-0.0	0.8	-1.0
Times rat made contact with spout	0.5	0.6	1.7	-0.8	0.0	0.1	-0.7	1.3
Lifetime Intake	0.1	0.1	0.4	-0.0	-0.2	-0.7	-0.2	-0.1
Liver weight, left	1.3	2.1	3.4	1.7	1.3	0.9	1.3	-1.8
Liver weight, right	0.9	1.6	4.9	0.9	1.0	0.2	1.0	-2.2
Locomotor activity	1.1	1.7	3.3	-0.8	-1.6	-1.8	-1.4	0.2
Locomotor testing distance	0.5	0.9	1.5	-0.7	-1.2	-1.2	-1.1	0.1
Locomotor testing rearing	0.6	1.1	2.8	-0.9	-1.7	-0.8	-1.0	-0.5
Locomotion in novel chamber	0.6	0.8	1.3	-0.8	-1.1	-0.9	-1.0	-0.0
Locomotion in novel chamber post-restriction	0.5	0.8	2.2	0.3	-1.5	-1.2	-0.6	-0.2
Fecal boli incidents, locomotor time 1	0.5	0.7	1.2	-0.1	0.9	1.1	0.5	1.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.5	0.5	0.4	-0.3	0.3	-1.2
Time >=10cm from walls, locomotor time 1	2.9	3.0	5.1	1.5	2.2	2.3	1.7	-0.1
Bouts of movement, locomotor time 1	3.1	3.5	7.2	-2.7	-1.8	-1.6	-2.1	0.6
Total resting periods, locomotor time 1	2.8	3.1	7.2	-2.7	-1.5	-1.2	-2.0	0.8
Rest time, locomotor task time 1	0.5	0.6	1.7	0.2	1.3	1.1	0.5	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.3	-0.1	0.2	-0.3
Vertical activity count, locomotor time 1	1.0	2.4	3.7	1.4	1.3	1.2	1.9	-1.8
Time >=10cm from walls, locomotor time 2	0.8	1.2	4.9	0.4	0.5	-0.0	0.7	-2.2
Bouts of movement, locomotor time 2	0.8	1.3	3.7	-1.9	-1.0	-0.9	-0.9	-0.3
Total resting periods, locomotor time 2	0.5	0.9	3.1	-1.8	-0.6	-0.6	-0.7	-0.2
Rest time, locomotor task time 2	0.6	0.8	1.9	0.3	1.0	0.9	0.0	1.4
Distance moved, locomotor task time 2	1.0	1.2	4.2	-0.3	-0.9	-0.8	-0.1	-2.0
Vertical activity count, locomotor time 2	2.4	3.4	9.8	1.2	0.9	0.7	2.1	-3.1
Light reinforcement 1	1.8	4.4	11.6	1.3	2.1	3.4	1.8	-1.0
Light reinforcement 2	4.1	6.3	13.4	1.7	2.6	3.7	2.4	-1.6
Bone: marrow area	1.3	2.8	4.4	1.9	1.5	0.9	1.7	-2.1
Bone: maximum diameter	0.8	1.6	4.7	2.2	0.6	-0.1	1.0	-1.4
Bone: maximum force	0.5	0.9	3.0	1.0	0.5	-0.0	0.5	-1.7
Bone: maximum moment	0.6	1.0	3.1	1.1	0.7	0.1	0.7	-1.8
Mean time between licks in bursts	0.4	1.0	1.8	0.8	0.9	1.3	1.3	-0.6
Mean num. licks in bursts	0.8	1.3	3.1	-1.0	-0.7	-0.3	-1.3	1.8
Cd content in liver	0.1	0.2	0.5	0.1	-0.2	0.0	0.5	-0.7
Co content in liver	1.0	1.2	3.3	-0.3	1.2	1.8	0.8	0.6
Cu content in liver	0.3	0.4	1.0	-0.7	-0.4	-0.2	-0.1	-1.0
Fe content in liver	0.0	0.0	0.1	-0.3	0.3	0.3	-0.0	0.0
K content in liver	0.5	0.5	1.1	0.7	-0.2	-1.1	0.4	-0.9
Mg content in liver	0.4	0.4	0.8	0.9	-0.1	-0.9	0.4	-0.2
Mn content in liver	1.0	1.1	2.1	1.5	0.7	-0.2	1.0	-1.3
Na content in liver	0.3	0.3	0.7	0.8	-0.2	-0.2	0.1	-0.8
Rb content in liver	0.2	0.3	0.5	-0.5	-0.4	-0.1	-0.7	0.6
Se content in liver	0.5	0.5	2.2	-0.0	-0.3	-0.5	0.4	-1.5
Sr content in liver	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.2	0.3
Zn content in liver	0.3	0.3	0.8	0.5	0.5	0.4	0.9	-0.3
Bone: minimum diameter	2.3	4.1	7.9	2.8	1.8	1.0	1.9	-2.2
Time in familiar zone, hab. session 1	0.6	0.6	2.1	-0.6	0.6	1.4	0.2	0.4
Time in novel zone, hab. session 1	1.5	1.5	3.8	-0.5	-1.3	-2.0	-1.2	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.0	-0.3	-0.2	-0.5	0.1
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	0.2	0.1	0.1	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.6	0.8	0.7	0.6	-0.2
Time in familiar zone, hab. session 2	0.7	0.7	1.6	0.4	1.1	1.3	0.8	-0.3
Time in novel zone, hab. session 2	0.4	0.4	1.1	-0.5	-0.8	-1.1	-0.5	-0.1
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.2	-0.1	0.1	0.0	-0.1
Total locomotion distance, hab. session 2	0.5	0.6	1.1	0.6	0.6	0.6	0.9	-1.1
Locomotion velocity, hab. session 2	0.4	0.6	1.0	0.5	0.6	0.7	0.9	-1.0
Novel to familiar place preference ratio	0.9	1.0	1.9	-0.8	-1.1	-1.4	-0.8	0.9
Novelty place preference	0.6	0.6	1.1	-0.7	-0.8	-1.0	-0.6	0.6
Time in novel zone, NPP test	0.6	0.6	0.9	-0.7	-0.8	-1.0	-0.6	0.8
Total zone transitions, NPP test	0.9	1.3	1.8	1.4	1.3	1.1	1.2	-0.7
Total locomotion distance, NPP test	0.6	0.8	1.4	1.2	1.1	0.5	1.1	-0.3
Locomotion velocity, NPP test	1.0	1.4	2.2	1.5	1.3	0.6	1.4	-0.9
Intraocular pressure	0.3	0.4	0.8	-0.6	-0.8	-0.6	-0.9	0.3
Delta distance traveled before/after self-admin	0.5	0.5	1.4	0.8	0.1	-0.1	0.6	-1.2
Delta ambulatory time before/after self-admin	1.3	1.6	2.9	1.7	0.8	1.0	1.6	-0.9
Parametrial fat weight	0.6	1.4	3.5	1.9	1.3	0.2	1.3	0.1
Pavlov. Cond. lever latency	0.2	0.2	0.6	-0.4	-0.5	-0.8	-0.5	0.1
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	-1.1	-1.0	-0.1	-0.9	0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.7	-0.2	0.2	0.8	0.4	-0.0
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.5	0.0	-0.3	0.4
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	0.1	0.3	-0.0	0.1
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	0.8	0.7	-0.0	0.6	-0.3
Pavlov. Cond. intertrial magazine entries	1.8	2.2	2.9	1.2	1.6	1.4	1.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.4	-0.7	-0.3	-0.4	0.4
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.6	-0.2	0.6	-0.3	0.7
Pavlov. Cond. lever latency	0.4	0.5	1.4	1.2	-0.2	-1.0	0.0	0.3
Pavlov. Cond. magazine entry latency	1.2	1.4	3.5	-0.2	1.1	1.9	0.9	-1.3
Pavlov. Cond. change in total contacts	0.5	0.8	3.0	-1.7	-0.5	0.2	-0.7	0.5
Pavlov. Cond. index score	0.5	0.7	1.6	-1.2	0.3	1.3	0.1	-0.5
Pavlov. Cond. latency score	0.6	0.7	1.9	-1.1	0.4	1.4	0.1	-0.6
Pavlov. Cond. lever contacts	0.5	0.6	1.9	-1.4	0.2	1.1	-0.0	-0.2
Pavlov. Cond. magazine entry number	0.7	0.8	2.5	0.7	-0.6	-1.6	-0.5	0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.9	0.3	-0.2	0.1	0.6	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.0	-1.1	0.4	1.4	0.2	-0.5
Pavlov. Cond. response bias	0.5	0.7	1.4	-1.0	0.3	1.2	0.3	-0.8
Time in closed arm before self-admin	0.1	0.1	0.2	0.3	0.4	0.1	0.3	0.3
Time in closed arm after self-admin	0.9	0.9	2.2	0.3	0.8	1.5	1.1	0.8
Time in open arm before self-admin	0.1	0.1	0.2	0.3	-0.1	-0.0	-0.4	0.0
Time in open arm after self-admin	1.1	1.2	2.3	-0.4	-1.2	-1.5	-1.4	-0.4
Bone: periosteal estimation	1.6	3.4	5.8	2.3	1.4	0.7	1.8	-2.4
Bone: periosteal perimeter	1.9	3.2	7.0	2.6	1.0	0.1	1.8	-2.2
Bone: post-yield work	0.7	1.1	1.8	1.4	1.2	0.7	1.0	-0.8
Progressive ratio test 1 active lever presses	0.7	0.9	2.2	-0.1	-1.2	-1.5	-0.9	0.3
Progressive ratio test 1 breakpoint	0.8	0.9	2.2	-0.1	-1.2	-1.5	-1.0	0.3
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.8	1.4	-0.0	-0.8	0.3	-0.5
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	-0.3	-0.6	-1.0	-0.9	0.1
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	-0.3	-0.6	-1.0	-0.9	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.7	-0.3	-0.3	-0.4	-0.3	-0.8
Incentive Sensitization - Responses	0.5	0.7	1.4	-0.8	-0.5	-0.6	-1.2	0.9
Incentive Sensitization - Breakpoint	0.4	0.5	1.0	-0.7	-0.3	-0.4	-1.0	0.9
Sum of active levers in priming session hrs 5-6	1.1	1.1	3.3	-1.8	-0.4	0.3	-1.1	0.7
Progressive ratio	0.2	0.2	1.1	-1.0	0.0	-0.0	-0.4	-0.0
Food seeking constrained by brief footshock	0.4	0.5	1.5	1.0	0.2	-0.1	0.2	1.2
Seeking ratio, punishment vs. effort	0.3	0.5	2.0	1.4	0.2	0.3	0.6	0.2
Retroperitoneal fat weight	1.6	6.7	11.5	3.4	2.9	1.4	3.1	-1.4
Reaction time number correct	0.0	0.1	0.2	-0.2	0.5	0.1	0.3	-0.3
Reaction time mean minus median	0.2	0.5	1.4	-0.7	-0.4	-1.2	-0.6	0.3
Reaction time mean minus median AUC	0.5	1.3	3.1	-1.3	-1.0	-1.8	-0.9	-0.1
Reaction time num false alarms	0.8	1.1	1.9	-1.4	-1.0	-1.1	-1.0	0.0
Reaction time num false alarms AUC	1.0	1.6	2.6	-1.6	-1.4	-1.2	-1.3	0.4
Reaction time trials correct on left	0.0	0.1	0.2	-0.2	0.5	0.1	0.3	-0.3
Reaction time trials on left	0.1	0.1	0.2	-0.3	0.4	-0.1	0.2	-0.4
Reaction time mean	1.0	1.6	3.2	-1.3	-1.2	-1.8	-1.2	0.3
Reaction time mean AUC	0.9	1.4	3.0	-1.2	-1.1	-1.7	-1.2	-0.0
Median of all reaction times	0.9	1.3	2.4	-1.2	-1.1	-1.6	-1.1	0.3
Reaction time omissions	1.4	2.0	3.4	-1.8	-1.4	-1.7	-1.2	-0.8
Reaction time false alarm rate	1.0	1.3	1.9	-1.4	-1.4	-1.0	-1.3	0.5
Reaction time premature initiation rate	0.2	0.3	0.7	-0.7	0.5	0.8	0.0	-0.2
Reaction time premature initiations	0.2	0.4	0.7	-0.8	0.7	0.7	0.2	-0.4
Std. dev. reaction times	0.5	1.0	2.5	-0.8	-0.7	-1.6	-1.0	0.3
Reaction time trials completed	0.1	0.1	0.2	-0.3	0.4	-0.1	0.2	-0.4
Reaction time trials AUC	0.1	0.1	0.3	-0.2	0.5	0.0	0.4	-0.4
Run reversals in cocaine runway, females	2.6	2.6	6.2	1.4	1.0	0.5	1.9	-2.5
Run reversals in cocaine runway, males	0.4	0.4	1.0	-0.0	-0.3	-0.3	-0.8	1.0
Latency to leave start box in cocaine runway	0.6	0.7	1.7	-0.5	-1.0	-1.3	-0.6	-0.2
Latency to leave start box in cocaine runway, F	2.8	3.2	5.5	-1.3	-2.1	-2.4	-1.9	0.8
Latency to leave start box in cocaine runway, M	1.2	1.1	1.8	0.6	1.0	0.8	1.4	-1.4
Std. dev. time between licks in bursts	0.8	1.0	2.1	0.8	1.0	0.8	1.4	-0.9
Total sessions with >9 infusions	1.3	1.5	3.6	-0.6	-1.4	-1.9	-1.1	0.7
Short access day 1 total inactive lever presses	0.5	0.7	2.8	1.7	0.2	0.1	0.5	-0.4
Short access day 10 total inactive lever presses	0.1	0.2	0.5	0.7	0.1	-0.3	-0.3	-0.3
Short access day 1 total infusions	0.5	0.6	1.5	1.2	-0.2	-1.2	0.2	0.4
Short access day 10 total infusions	0.4	0.6	1.6	-0.2	-0.8	-1.3	-0.6	0.3
Short access total infusions	0.4	0.6	1.7	0.1	-0.9	-1.3	-0.5	0.2
Short access day 1 locomotion	0.4	0.4	0.7	0.8	-0.2	-0.8	0.4	-0.9
Short access day 10 total locomotion	0.7	1.4	2.5	-0.9	-1.2	-1.6	-1.4	0.4
Short access total locomotion	0.4	0.5	1.6	-0.0	-0.6	-1.3	-0.5	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.6	-0.4	0.6	0.4	-0.0	-0.7
Compulsive drug intake	1.3	1.5	2.6	1.2	1.3	1.2	1.6	-0.7
One hour access (shock baseline)	0.7	1.1	3.0	-1.7	-0.6	-0.7	-1.3	0.1
Social response proportion	0.2	0.3	0.5	0.7	0.5	0.7	0.2	-0.2
Social responses	0.2	0.3	0.7	-0.2	0.3	0.7	-0.4	0.9
Social time	0.3	0.4	0.8	0.9	0.5	0.9	0.2	-0.3
Soleus weight	0.4	1.1	2.1	1.5	1.3	0.8	0.9	-0.5
Bone: stiffness	0.5	0.8	3.2	0.5	-0.2	-0.6	-0.1	-1.8
Tibialis anterior weight	0.1	0.2	0.3	-0.4	-0.4	0.4	-0.4	0.5
Time to tail flick, vehicle, before self-admin	0.5	0.6	2.2	0.7	0.1	-0.3	-0.1	1.5
Time to tail flick, vehicle, after self-admin	0.4	0.6	1.7	0.5	1.3	0.8	0.6	0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.2	0.5	0.9	0.6	-0.3
Time to tail flick, test, after self-admin	0.8	0.8	1.4	1.1	0.9	1.2	0.7	-0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.6	0.1	0.4	0.7	0.5	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.8	0.4	0.1	0.2	-0.5
Tibia length	0.0	0.1	0.1	0.4	0.0	0.2	-0.1	-0.3
Ambulatory time before self-admin	1.5	2.2	3.2	-1.6	-1.4	-1.7	-1.8	0.7
Ambulatory time after self-admin	0.0	0.1	0.1	0.3	0.3	0.1	0.2	0.2
Bone: tissue strength	0.0	0.0	0.1	0.1	0.2	0.3	0.1	0.1
Total heroin consumption	0.2	0.2	0.6	-0.2	-0.6	-0.8	-0.5	-0.2
Bone: trabecular number	0.4	0.7	1.4	1.2	1.1	0.7	0.4	0.5
Bone: trabecular spacing	0.2	0.3	0.6	-0.2	-0.7	-0.8	-0.4	-0.2
Bone: trabecular thickness	0.8	1.0	1.9	1.4	1.2	0.8	1.1	-0.1
Bone: trabecular tissue density	0.9	1.3	2.9	-0.5	-1.7	-1.5	-1.0	-0.2
Water consumed over 24 hours	0.1	0.2	0.4	-0.6	0.4	0.7	-0.0	-0.1
Number of responses in last shaping day	2.4	2.6	4.0	-1.2	-1.8	-1.7	-2.0	1.2