Hub : Genes

Hgf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Hgf 0.07 0.04 4.7e-05 0.03 0.03 0.03 0.03 5.3e-04 3.7e-04 2.5e-04 7.4e-04
2 IL gene expression Hgf 0.6 0.14 4.4e-12 0.45 0.42 0.46 0.44 3.3e-12 2.3e-11 1.3e-12 7.0e-12
3 PL gene expression Hgf 0.37 0.12 0.0e+00 0.38 0.4 0.41 0.41 2.0e-43 4.8e-47 5.2e-48 1.0e-48
4 Brain alternative polyA NM_017017.2 0.02 0.02 5.8e-03 0.02 0.02 0.01 0.02 2.7e-03 8.5e-03 2.2e-02 8.2e-03
5 BLA alternative polyA XM_006235979.5 0.05 0.04 7.8e-03 0.01 0.02 0.01 0.01 6.0e-02 2.2e-02 9.0e-02 6.5e-02
6 Brain alternative polyA XM_006235979.5 0.02 0.01 8.2e-03 0.02 0.02 0.02 0.02 3.0e-03 9.8e-03 9.9e-03 5.3e-03
7 BLA alternative polyA NM_017017.2 0.06 0.05 2.7e-03 0.03 0.03 0 0.03 1.6e-02 6.2e-03 2.5e-01 1.4e-02
8 Adipose gene expression Hgf 0.14 0.07 1.9e-13 0.09 0.09 0.09 0.09 5.9e-10 1.7e-10 2.1e-10 1.7e-10
9 Liver gene expression Hgf 0.03 0.02 1.8e-04 0.03 0.02 0.01 0.01 8.4e-04 4.7e-03 6.5e-02 1.2e-02
10 BLA alternative polyA NM_017017.2 0.06 0.04 6.0e-03 0.05 0.03 0.03 0.03 1.9e-03 1.4e-02 1.8e-02 9.6e-03
11 PL mRNA stability Hgf 0.02 0.02 3.2e-03 0.02 0.02 0.01 0.02 3.7e-03 2.8e-03 5.7e-02 5.9e-03
12 Brain gene expression Hgf 0.16 0.08 3.0e-07 0.07 0.08 0.07 0.07 2.8e-07 1.1e-07 4.5e-07 7.9e-07
13 NAcc gene expression Hgf 0.09 0.05 1.5e-06 0 0.05 0.04 0.03 7.4e-02 1.4e-07 1.9e-07 1.6e-05
14 IC gene expression Hgf 0.66 0.15 2.0e-14 0.19 0.24 0.27 0.24 2.1e-08 1.2e-10 1.3e-11 1.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.30.60.7-0.7-0.70.2-0.3-0.50.30.5-0.30.6-0.3-0.6-0.4-0.3
Area under the delay curve0.00.00.2-0.50.20.1-0.10.10.3-0.1-0.10.1-0.20.10.1-0.00.1
BMI with tail0.00.10.30.30.2-0.1-0.40.50.0-0.5-0.30.30.20.6-0.1-0.40.1
BMI without tail0.10.30.7-0.20.30.3-0.90.70.7-0.7-0.40.3-0.30.7-0.0-0.50.6
Body weight0.00.10.40.4-0.2-0.20.3-0.1-0.60.10.1-0.10.4-0.1-0.10.10.1
Weight adjusted by age0.50.81.71.3-1.0-1.20.3-0.5-0.40.51.0-1.01.0-0.4-1.3-1.1-0.7
Bone surface0.20.41.0-0.50.50.50.10.5-0.4-0.5-0.70.9-0.40.50.80.81.0
Bone volume0.10.30.80.6-0.6-0.60.6-0.5-0.90.50.5-0.20.6-0.4-0.30.1-0.0
Breakpoint value in progressive ratio session0.80.91.90.9-1.1-0.80.1-0.90.01.01.1-1.31.4-1.0-1.0-0.7-1.1
Number of licking bursts0.50.81.30.6-0.9-0.80.8-1.1-0.61.11.0-1.01.0-1.1-0.50.2-0.9
Context. condit. distance diff. score0.50.61.0-0.70.80.8-0.71.00.5-1.0-0.81.0-0.91.00.4-0.21.0
Locomotion velocity, session 11.21.32.01.0-0.9-1.01.2-1.4-1.21.41.1-1.31.3-1.4-0.30.6-1.0
Locomotion distance, session 11.92.47.20.6-0.5-0.72.7-1.8-2.71.60.7-0.81.0-1.70.92.50.2
Locomotion velocity, session 20.50.61.31.1-0.7-0.90.1-0.6-0.30.60.8-0.80.9-0.5-0.9-0.7-1.2
Locomotion distance, session 20.50.71.30.3-0.4-0.41.1-1.1-1.01.00.5-0.70.9-1.10.31.1-0.5
Locomotion velocity, session 30.80.92.31.0-0.9-1.01.3-1.1-1.51.10.9-0.80.9-1.1-0.30.6-0.6
Locomotion distance, session 30.10.10.5-0.50.30.40.3-0.10.00.1-0.20.1-0.1-0.10.60.70.2
Stereotopy head waving bouts, day 31.01.22.80.9-1.1-1.11.4-1.3-1.71.31.1-1.20.9-1.3-0.60.3-0.3
Stereotopy head waving duration, day 30.91.13.60.7-0.9-0.81.5-1.3-1.91.30.9-0.90.7-1.3-0.20.8-0.0
Locomotion velocity, session 70.30.40.9-0.60.70.60.30.3-0.6-0.3-0.60.5-0.40.30.91.00.9
Locomotion distance, session 70.40.50.8-0.90.80.9-0.50.70.2-0.7-0.90.9-0.80.70.80.50.6
Stereotopy head waving bouts, day 74.45.07.22.7-2.5-2.61.6-2.4-1.92.42.4-2.72.5-2.3-1.8-0.3-2.2
Stereotopy head waving duration, day 76.07.210.23.1-3.0-3.01.9-2.8-2.02.83.0-3.23.1-2.8-2.3-0.6-2.8
Locomotion velocity, session 81.11.32.40.9-0.8-0.91.4-1.4-1.51.41.0-1.11.3-1.4-0.30.7-0.8
Locomotion distance, session 80.00.10.1-0.20.20.2-0.20.3-0.0-0.3-0.20.3-0.20.30.1-0.10.4
Degree of sensitization distance1.21.22.1-0.91.10.9-1.31.40.8-1.4-1.11.4-1.41.50.4-0.40.9
Degree of sensitization stereotypy3.94.26.62.5-2.3-2.40.8-2.0-1.02.02.2-2.52.5-1.9-2.0-0.9-2.6
Conditioned locomotion0.40.40.8-0.90.80.9-0.80.70.7-0.7-0.70.5-0.40.60.4-0.10.4
Cocaine response after cond. corrected2.02.44.42.1-2.0-2.00.6-1.3-0.91.31.8-1.41.5-1.2-2.0-1.2-1.5
Cocaine response after cond. not corrected0.50.61.31.1-1.0-1.00.5-0.6-0.70.60.8-0.30.6-0.5-0.9-0.5-0.7
Cocaine response before conditioning2.02.34.0-1.81.91.8-0.31.20.3-1.3-1.81.9-1.61.22.01.51.6
Saline control response0.40.50.8-0.90.90.9-0.70.70.6-0.7-0.70.7-0.80.60.50.00.3
Bone: connectivity density0.10.10.30.00.0-0.00.20.2-0.5-0.2-0.30.5-0.10.20.30.40.5
Bone: cortical apparent density0.20.20.50.7-0.5-0.70.7-0.4-0.70.30.4-0.30.1-0.3-0.30.00.0
Bone: cortical area1.52.33.3-1.81.81.7-0.81.50.7-1.5-1.71.7-1.81.51.50.71.7
Bone: cortical porosity2.83.05.1-2.01.92.0-0.61.50.4-1.6-2.02.1-2.31.52.01.22.0
Bone: cortical porosity5.35.89.1-2.82.62.8-1.72.51.6-2.5-2.62.8-3.02.42.10.72.4
Bone: cortical thickness0.71.22.1-1.31.21.3-1.21.20.9-1.2-1.11.3-1.51.10.7-0.10.9
Bone: cortical thickness1.92.23.6-1.81.61.8-0.91.31.0-1.3-1.71.8-1.91.31.81.21.2
Bone: cortical tissue density0.20.20.70.8-0.6-0.80.7-0.4-0.70.40.5-0.30.1-0.3-0.4-0.0-0.0
Condit. Reinf. active minus inactive responses0.80.91.81.0-1.0-1.01.1-1.1-1.41.11.0-1.01.1-1.1-0.7-0.0-0.3
Condit. Reinf. active-inactive response ratio0.30.30.90.5-0.4-0.50.7-0.7-1.00.70.6-0.60.7-0.7-0.30.2-0.2
Condit. Reinf. active responses0.81.02.30.8-0.9-0.91.4-1.2-1.51.21.0-1.01.1-1.2-0.50.4-0.2
Condit. Reinf. inactive responses0.20.30.70.0-0.3-0.20.9-0.7-0.80.70.5-0.50.4-0.80.00.50.1
Incentive salience index mean0.60.73.10.5-0.4-0.51.6-0.9-1.80.80.6-0.60.7-0.80.00.70.5
Condit. Reinf. lever presses1.01.44.3-0.60.70.42.1-0.5-2.00.4-0.30.1-0.1-0.51.42.11.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.1-0.2-0.00.4-0.5-0.20.50.4-0.30.2-0.6-0.10.2-0.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.3-0.10.20.0-0.10.10.10.00.00.0-0.20.10.20.2
Condit. Reinf. active responses0.20.30.60.5-0.7-0.60.3-0.6-0.30.60.8-0.50.5-0.6-0.7-0.4-0.6
Condit. Reinf. inactive responses0.91.22.51.4-1.2-1.3-0.0-0.7-0.20.81.2-1.00.9-0.7-1.6-1.3-1.4
Condit. Reinf. lever presses2.53.55.42.2-2.3-2.30.9-1.8-1.01.82.2-1.91.8-1.7-2.2-1.3-1.9
Condit. Reinf. lever reinforcers received0.60.81.20.9-1.1-0.90.5-1.0-0.51.01.1-0.90.9-1.0-1.0-0.6-0.9
Conditioned reinforcement - actives0.10.20.8-0.30.60.20.6-0.1-0.50.0-0.30.1-0.1-0.10.80.90.4
Conditioned reinforcement - inactives0.10.20.50.4-0.3-0.60.4-0.6-0.50.60.4-0.70.6-0.5-0.00.2-0.3
Conditioned locomotion0.10.10.4-0.10.40.10.50.2-0.6-0.3-0.30.4-0.30.20.40.40.6
Patch foraging indifference point 0 sec0.50.92.71.3-1.1-1.3-0.1-0.4-0.40.51.1-0.50.5-0.4-1.6-1.6-0.9
Patch foraging indifference point AUC0.10.10.60.30.0-0.10.70.1-0.4-0.2-0.30.20.30.20.50.80.2
Delay disc. indifference point, 0s delay0.10.10.30.4-0.0-0.60.00.2-0.2-0.20.1-0.30.20.3-0.4-0.5-0.3
Delay disc. indifference point, 16s delay0.10.10.30.2-0.5-0.3-0.1-0.20.50.20.4-0.20.1-0.2-0.4-0.3-0.2
Delay disc. indifference point, 2s delay0.20.20.7-0.40.80.20.20.3-0.2-0.3-0.5-0.20.00.30.70.60.4
Delay disc. indifference point, 24s delay0.20.20.7-0.70.00.10.7-0.4-0.50.3-0.00.1-0.2-0.40.50.80.5
Delay disc. indifference point, 4s delay0.10.10.3-0.40.60.3-0.10.30.2-0.3-0.40.0-0.10.30.50.30.1
Delay disc. indifference point, 8s delay0.10.10.6-0.80.10.2-0.0-0.10.10.10.00.3-0.4-0.10.00.00.0
Indifference point function ln k0.10.20.9-0.20.30.1-0.40.3-0.0-0.3-0.10.5-1.00.3-0.1-0.30.5
Indifference point function log k0.10.20.9-0.20.30.1-0.40.3-0.0-0.3-0.10.5-1.00.3-0.1-0.30.5
Patch foraging total patch changes 0 sec0.61.23.31.4-1.2-1.4-0.2-0.5-0.30.51.2-0.70.7-0.4-1.8-1.8-1.2
Patch foraging total patch changes 12 sec0.20.21.00.7-0.4-0.70.7-0.2-1.00.10.2-0.20.5-0.1-0.10.2-0.0
Patch foraging total patch changes 18 sec1.93.04.82.2-1.9-2.21.4-1.7-1.51.71.9-1.71.9-1.6-1.6-0.5-1.6
Patch foraging total patch changes 24 sec0.91.63.11.7-1.4-1.61.2-1.1-1.71.11.2-1.21.3-1.1-1.0-0.1-0.8
Patch foraging total patch changes 6 sec3.55.38.02.8-2.8-2.81.0-2.0-1.32.12.7-2.52.6-2.0-2.8-1.8-2.3
Patch foraging time to switch 0 sec0.20.30.8-0.3-0.20.10.6-0.8-0.30.80.4-0.80.5-0.90.30.7-0.1
Patch foraging water rate 0 sec0.20.30.80.00.60.00.40.6-0.9-0.7-0.60.7-0.50.70.50.30.8
Patch foraging water rate 12 sec1.22.44.71.5-1.6-1.42.2-1.9-1.91.91.6-1.51.4-1.9-0.80.5-0.8
Patch foraging water rate 18 sec1.42.26.61.2-1.0-1.22.4-1.8-2.61.71.3-1.11.1-1.7-0.31.0-0.4
Patch foraging water rate 24 sec0.20.31.40.7-0.2-0.71.0-0.3-1.20.30.3-0.20.3-0.2-0.10.40.1
Patch foraging water rate 6 sec0.20.31.1-0.0-0.00.01.1-0.2-1.00.2-0.10.1-0.2-0.20.51.00.7
Seeking ratio, delayed vs. immediate footshock0.70.82.0-1.21.21.2-0.30.60.4-0.7-1.10.5-0.50.61.41.10.9
Distance traveled before self-admin0.70.92.31.5-1.1-1.41.1-0.7-0.80.60.9-1.10.8-0.6-0.9-0.3-0.5
Distance traveled after self-admin0.10.20.6-0.10.20.20.8-0.3-0.70.30.00.0-0.1-0.30.40.70.6
Extensor digitorum longus weight0.10.30.6-0.30.30.3-0.80.60.6-0.6-0.30.5-0.60.6-0.1-0.50.3
Bone: elastic displacement1.11.21.8-1.21.11.2-1.41.21.2-1.2-1.21.2-1.41.20.7-0.10.7
Bone: elastic work0.40.61.1-1.00.91.0-0.10.50.2-0.5-0.80.7-0.80.41.00.70.8
Bone: endosteal estimation0.10.20.8-0.10.10.00.7-0.5-0.80.50.1-0.30.6-0.50.50.90.2
Bone: endosteal perimeter0.71.43.0-1.11.41.10.20.9-0.3-1.0-1.41.3-0.90.91.71.51.7
Epididymis fat weight1.75.79.03.0-2.8-2.81.5-2.2-1.92.32.7-2.32.9-2.2-2.6-1.2-2.3
Delta time in closed arm before/after self-admin0.80.84.40.20.40.21.2-0.7-0.80.6-0.3-0.50.6-0.61.42.10.3
Delta time in open arm before/after self-admin0.90.92.0-1.00.90.9-0.91.00.6-1.0-0.81.3-1.41.00.2-0.50.5
Diff in mean of infusions in LGA sessions1.31.64.41.0-1.2-1.11.4-1.3-0.71.41.2-1.92.1-1.4-0.60.3-0.9
Delay discount exponential model param0.20.20.60.8-0.5-0.40.1-0.3-0.30.30.4-0.30.4-0.3-0.5-0.3-0.4
Extinction: sum of active levers before priming2.22.44.11.7-1.5-1.21.8-1.9-1.61.91.6-1.82.0-1.9-0.70.5-1.0
Active lever presses in extinction session 61.21.22.50.4-0.6-0.41.2-1.4-1.21.41.0-1.51.6-1.5-0.10.7-0.8
Bone: final force0.20.30.5-0.70.70.7-0.70.70.5-0.6-0.50.6-0.40.60.1-0.50.4
Bone: final moment0.30.51.0-1.00.91.0-0.50.70.4-0.7-0.70.8-0.50.60.4-0.10.6
Food consumed during 24 hour testing period0.70.93.8-0.80.30.61.6-0.6-1.20.6-0.2-0.00.2-0.71.32.01.1
Glucose0.20.31.00.00.2-0.01.0-0.2-0.90.1-0.20.20.1-0.10.71.00.4
Heart weight0.81.33.50.4-0.4-0.31.8-1.3-1.91.20.5-0.91.0-1.30.61.7-0.1
Delay discount hyperbolic model param0.20.20.60.8-0.6-0.40.2-0.3-0.30.30.5-0.20.4-0.3-0.5-0.3-0.3
Intermittent access intake day 1-15 change0.20.42.1-0.40.40.60.7-0.3-0.20.3-0.3-0.40.1-0.41.01.50.8
Intermittent access intake escalation0.20.52.1-0.10.10.31.1-0.6-0.80.60.0-0.60.4-0.60.81.40.7
Intermittent access intake escalation 21.31.53.7-1.51.51.60.20.60.0-0.7-1.30.8-0.90.51.91.91.7
Intermitt. access day 1 inactive lever presses0.62.14.0-1.21.21.3-2.01.81.9-1.7-1.41.6-1.41.80.6-0.60.8
Intermitt. access day 15 inactive lever presses0.00.10.30.0-0.10.0-0.60.20.5-0.20.00.0-0.10.2-0.3-0.5-0.0
Intermitt. access escalation Index0.60.83.10.3-0.8-0.3-1.50.41.8-0.40.20.3-0.30.5-1.1-1.6-0.9
Intermittent access day 1 total infusions1.21.93.61.7-1.7-1.90.3-1.1-0.51.21.7-1.21.1-1.1-1.9-1.4-1.7
Intermittent access day 15 total infusions0.91.31.91.3-1.2-1.30.9-1.3-0.81.31.3-1.41.1-1.3-0.9-0.1-0.9
Intermittent access terminal intake (last 3 days)0.60.81.60.6-0.8-0.70.9-1.3-0.61.20.9-1.10.8-1.3-0.10.7-0.4
Intermittent access total infusions1.11.32.31.0-1.2-1.21.1-1.5-1.01.51.2-1.41.1-1.5-0.50.4-0.8
Intermittent access day 1 locomotion0.60.81.61.2-1.2-1.30.3-0.7-0.40.71.1-0.60.6-0.7-1.3-0.9-0.9
Intermittent access day 15 total locomotion0.40.72.00.6-0.6-0.71.3-1.0-1.40.90.7-0.70.5-0.9-0.20.60.1
Intermittent access total locomotion1.31.63.50.9-1.0-1.01.8-1.6-1.91.61.1-1.21.0-1.6-0.11.2-0.1
Intermittent access standard deviation0.00.10.3-0.10.10.1-0.2-0.30.00.30.2-0.60.4-0.40.00.1-0.2
Left kidney weight0.41.82.4-1.41.51.5-1.31.51.4-1.5-1.61.3-1.41.51.20.31.1
Right kidney weight0.31.63.3-1.00.91.0-1.81.51.8-1.5-1.21.3-1.21.50.3-0.80.5
Cocaine induced anxiety0.50.81.4-0.90.90.9-0.71.00.7-1.0-0.91.2-1.20.90.70.10.7
Post-drug Anxiety1.01.11.7-1.31.31.3-0.51.00.7-1.0-1.21.3-1.11.01.10.51.0
Baseline Anxiety0.00.00.1-0.00.1-0.00.3-0.1-0.20.10.1-0.10.2-0.20.00.1-0.0
Tail length0.00.00.1-0.1-0.10.10.1-0.10.30.10.1-0.40.0-0.1-0.1-0.00.3
Length with tail0.10.20.40.3-0.6-0.30.6-0.7-0.50.70.5-0.50.6-0.7-0.20.2-0.1
Length without tail0.41.12.01.1-1.1-1.00.8-1.2-1.01.21.2-1.11.4-1.2-0.8-0.1-1.2
Times rat made contact with spout1.01.22.71.1-1.4-1.1-0.1-0.80.10.91.2-0.91.2-0.8-1.5-1.2-1.6
Lifetime Intake0.91.21.91.0-1.0-1.11.1-1.4-1.01.41.1-1.31.1-1.3-0.50.4-0.7
Liver weight, left0.00.10.3-0.10.1-0.00.4-0.1-0.50.1-0.0-0.10.0-0.10.20.40.5
Liver weight, right2.03.55.2-2.32.22.2-0.91.71.1-1.8-2.11.9-1.91.72.11.22.2
Locomotor activity0.10.10.40.3-0.1-0.10.4-0.2-0.60.1-0.00.2-0.0-0.10.30.60.2
Locomotor testing distance0.20.31.50.00.20.00.9-0.3-1.20.2-0.10.2-0.0-0.20.71.20.6
Locomotor testing rearing0.00.10.3-0.40.30.4-0.10.1-0.0-0.1-0.20.5-0.20.10.30.20.5
Locomotion in novel chamber0.20.30.7-0.70.60.70.6-0.1-0.60.1-0.30.10.0-0.20.70.80.8
Locomotion in novel chamber post-restriction0.81.42.71.1-0.8-1.10.2-1.0-0.41.11.3-1.71.6-1.1-1.3-1.0-1.6
Fecal boli incidents, locomotor time 10.30.52.1-0.0-0.0-0.31.4-0.7-1.40.60.2-0.50.1-0.70.40.90.5
Change in fecal boli incidents, locomotor task0.00.00.20.4-0.2-0.20.1-0.2-0.10.20.1-0.00.3-0.2-0.00.1-0.4
Time >=10cm from walls, locomotor time 13.74.07.5-2.72.42.4-1.01.91.0-2.0-2.32.3-2.01.82.11.02.0
Bouts of movement, locomotor time 11.51.76.81.1-1.7-1.3-1.1-0.11.00.21.2-0.2-0.1-0.0-2.3-2.6-1.5
Total resting periods, locomotor time 11.41.66.31.1-1.6-1.3-1.0-0.20.80.31.2-0.2-0.0-0.1-2.3-2.5-1.4
Rest time, locomotor task time 11.21.52.71.5-1.4-1.60.9-1.2-1.21.21.4-0.90.9-1.1-1.3-0.5-1.3
Distance moved, locomotor task time 14.06.09.0-3.02.92.8-1.42.41.3-2.5-2.82.6-2.82.42.61.32.7
Vertical activity count, locomotor time 10.81.92.7-1.51.61.6-0.91.41.0-1.5-1.61.3-1.51.41.40.61.7
Time >=10cm from walls, locomotor time 20.60.93.0-1.71.01.1-0.60.50.2-0.5-1.00.7-0.90.41.31.00.9
Bouts of movement, locomotor time 20.30.51.70.1-0.2-0.1-1.30.61.2-0.6-0.00.6-0.70.7-0.7-1.3-0.2
Total resting periods, locomotor time 20.20.41.30.4-0.3-0.3-0.90.30.9-0.30.20.5-0.50.4-0.8-1.1-0.3
Rest time, locomotor task time 20.20.20.6-0.20.50.5-0.30.50.4-0.5-0.40.8-0.70.50.2-0.10.6
Distance moved, locomotor task time 20.40.41.1-1.10.40.6-0.90.70.6-0.7-0.70.7-1.00.60.50.00.3
Vertical activity count, locomotor time 20.30.41.3-0.40.30.3-1.10.80.9-0.8-0.60.5-0.70.80.2-0.40.1
Light reinforcement 10.41.12.31.5-1.1-1.50.5-0.8-0.80.81.1-1.01.2-0.8-1.1-0.6-1.1
Light reinforcement 20.10.20.3-0.40.50.4-0.40.50.5-0.5-0.60.5-0.50.50.50.20.2
Bone: marrow area0.10.20.8-0.10.20.10.7-0.4-0.80.4-0.0-0.20.5-0.50.60.90.2
Bone: maximum diameter4.58.411.7-3.23.43.2-1.22.81.2-2.9-3.43.4-3.12.83.32.03.3
Bone: maximum force0.81.42.2-1.51.51.5-0.71.20.7-1.2-1.31.4-0.91.21.10.31.1
Bone: maximum moment1.01.72.9-1.71.71.7-0.61.30.6-1.3-1.51.5-1.11.21.40.71.3
Mean time between licks in bursts0.10.31.20.2-0.4-0.2-0.70.10.9-0.00.3-0.30.40.1-0.8-1.1-0.7
Mean num. licks in bursts0.10.20.50.2-0.0-0.0-0.60.40.5-0.4-0.10.3-0.20.5-0.4-0.7-0.1
Cd content in liver1.11.22.01.4-1.3-1.41.0-1.1-1.01.11.2-1.10.9-1.0-1.0-0.3-0.9
Co content in liver1.11.22.51.2-0.8-1.11.5-1.2-1.61.20.9-1.31.3-1.2-0.20.8-0.5
Cu content in liver0.40.51.70.6-0.8-0.6-0.6-0.10.80.10.6-0.50.2-0.1-1.1-1.3-0.8
Fe content in liver0.30.40.90.5-0.8-0.60.1-0.60.00.60.7-1.00.8-0.6-0.6-0.4-0.8
K content in liver0.80.73.10.5-0.5-0.3-1.40.71.2-0.70.10.4-0.20.8-1.1-1.8-0.4
Mg content in liver1.01.04.60.9-1.0-0.8-1.20.21.1-0.10.7-0.30.40.2-1.7-2.1-1.0
Mn content in liver1.51.77.81.4-1.1-1.0-1.60.51.3-0.50.7-0.10.30.7-2.2-2.8-1.0
Na content in liver0.20.30.70.5-0.6-0.5-0.3-0.20.10.30.6-0.40.4-0.2-0.8-0.8-0.6
Rb content in liver1.31.62.61.6-1.3-1.61.1-1.2-1.21.21.4-1.41.4-1.1-1.2-0.5-1.0
Se content in liver2.32.711.01.0-1.4-0.9-2.50.42.2-0.21.0-0.40.20.4-2.5-3.3-1.9
Sr content in liver0.30.20.5-0.20.30.3-0.50.60.2-0.6-0.50.6-0.50.70.1-0.20.6
Zn content in liver0.91.01.81.0-1.3-1.20.0-1.0-0.21.01.2-1.10.7-1.0-1.2-0.8-1.4
Bone: minimum diameter0.81.52.7-1.41.51.4-0.31.10.2-1.1-1.41.4-1.31.11.51.01.7
Time in familiar zone, hab. session 10.10.10.50.5-0.1-0.40.5-0.0-0.7-0.00.0-0.10.20.00.10.3-0.0
Time in novel zone, hab. session 11.21.22.1-1.51.21.4-1.11.01.1-1.0-1.11.2-1.30.90.90.11.0
Total zone transitions, hab. session 10.50.73.0-0.20.40.21.4-0.2-1.50.0-0.50.6-0.4-0.11.11.71.1
Total locomotion distance, hab. session 10.91.32.3-0.91.41.1-0.51.20.2-1.3-1.41.3-1.51.31.30.91.1
Locomotion velocity, hab. session 10.30.50.9-0.40.80.5-0.10.7-0.2-0.8-0.90.8-0.90.80.90.80.6
Time in familiar zone, hab. session 20.50.50.8-0.60.90.8-0.50.80.9-0.9-0.90.7-0.40.80.70.20.2
Time in novel zone, hab. session 21.01.01.70.7-1.1-0.91.0-1.3-1.31.31.2-1.10.8-1.3-0.70.1-0.2
Total zone transitions, hab. session 20.10.10.5-0.1-0.00.0-0.40.40.1-0.4-0.00.4-0.40.4-0.4-0.70.3
Total locomotion distance, hab. session 21.11.52.8-0.81.10.9-1.51.61.2-1.6-1.21.4-1.41.70.3-0.60.7
Locomotion velocity, hab. session 21.01.32.6-0.71.10.9-1.41.51.0-1.5-1.21.4-1.31.60.4-0.40.5
Novel to familiar place preference ratio0.40.42.30.3-0.4-0.2-1.10.30.8-0.30.3-0.20.10.3-1.0-1.5-0.4
Novelty place preference0.50.52.50.2-0.3-0.2-1.30.41.0-0.40.2-0.10.10.4-1.0-1.6-0.5
Time in novel zone, NPP test0.40.42.10.1-0.2-0.1-1.20.50.8-0.40.1-0.00.00.5-0.9-1.4-0.3
Total zone transitions, NPP test0.60.92.30.5-0.7-0.61.5-1.2-1.41.20.8-0.80.9-1.2-0.00.8-0.1
Total locomotion distance, NPP test0.30.40.6-0.70.80.7-0.70.80.7-0.8-0.80.6-0.70.80.5-0.00.3
Locomotion velocity, NPP test0.40.60.9-0.70.90.8-0.81.00.9-1.0-0.90.8-0.90.90.5-0.10.3
Intraocular pressure0.91.32.90.8-0.8-0.91.7-1.5-1.71.51.1-1.11.1-1.5-0.30.7-0.4
Delta distance traveled before/after self-admin1.81.93.7-1.81.91.8-0.40.90.1-0.9-1.41.6-1.40.81.81.31.5
Delta ambulatory time before/after self-admin0.81.02.4-1.51.51.4-0.90.80.4-0.7-1.01.1-0.90.71.00.41.0
Parametrial fat weight0.81.93.9-0.81.21.0-1.71.91.5-1.9-1.51.6-1.42.00.5-0.60.9
Pavlov. Cond. lever latency0.91.22.80.8-1.3-0.8-1.2-0.41.30.51.0-0.80.7-0.5-1.5-1.6-1.7
Pavlov. Cond. magazine entry latency1.41.84.2-1.82.01.80.00.90.1-1.0-1.60.9-0.80.82.01.51.5
Pavlov. Cond. change in total contacts0.60.71.6-0.91.30.90.40.5-0.6-0.5-0.80.7-0.70.51.10.91.1
Pavlov. Cond. index score1.21.53.3-1.31.71.30.80.6-0.7-0.7-1.30.8-0.70.61.81.71.6
Pavlov. Cond. latency score0.81.02.4-0.91.41.00.90.5-0.9-0.5-1.00.7-0.60.51.51.51.4
Pavlov. Cond. lever contacts1.11.42.9-1.21.61.20.60.8-0.6-0.9-1.31.1-1.00.81.61.31.7
Pavlov. Cond. magazine entry number1.01.33.11.5-1.7-1.5-0.1-0.80.20.81.3-0.80.6-0.7-1.6-1.3-1.4
Pavlov. Cond. intertrial magazine entries0.50.62.5-0.1-0.6-0.0-1.20.51.6-0.50.10.3-0.30.5-0.9-1.6-0.1
Pavlov. Cond. lever-magazine prob. diff.1.41.73.9-1.51.91.50.60.8-0.5-0.9-1.51.0-0.80.72.01.71.7
Pavlov. Cond. response bias2.32.95.7-2.02.42.10.21.3-0.1-1.4-2.01.5-1.31.32.31.82.1
Pavlov. Cond. lever latency0.70.91.9-1.11.21.1-0.20.80.1-0.9-1.10.9-1.00.81.20.81.4
Pavlov. Cond. magazine entry latency0.00.00.1-0.30.20.2-0.0-0.0-0.10.1-0.00.0-0.0-0.10.0-0.00.1
Pavlov. Cond. change in total contacts0.40.71.21.1-0.8-1.10.4-0.7-0.50.70.9-0.80.8-0.7-1.0-0.7-1.1
Pavlov. Cond. index score0.40.50.70.7-0.7-0.70.5-0.7-0.50.70.8-0.70.8-0.7-0.7-0.3-0.9
Pavlov. Cond. latency score0.20.30.50.6-0.5-0.60.5-0.6-0.60.60.6-0.50.7-0.6-0.4-0.0-0.7
Pavlov. Cond. lever contacts0.91.22.21.2-1.3-1.30.2-1.0-0.21.01.3-1.11.1-1.0-1.3-0.9-1.5
Pavlov. Cond. magazine entry number0.00.00.10.1-0.2-0.10.3-0.2-0.30.20.0-0.1-0.0-0.10.10.40.3
Pavlov. Cond. intertrial magazine entries0.50.72.2-1.51.01.3-0.20.30.5-0.3-0.80.4-0.40.11.21.00.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.6-0.6-0.70.5-0.7-0.50.70.8-0.60.8-0.7-0.6-0.2-0.8
Pavlov. Cond. response bias0.71.01.51.0-1.2-1.10.2-0.9-0.20.91.2-1.01.1-0.9-1.2-0.9-1.2
Time in closed arm before self-admin0.70.91.6-1.20.90.9-0.61.10.7-1.1-0.91.1-1.11.10.5-0.31.0
Time in closed arm after self-admin1.21.22.7-1.01.41.4-0.10.90.5-0.9-1.41.0-0.70.91.61.21.5
Time in open arm before self-admin0.20.20.70.30.2-0.40.4-0.2-0.40.2-0.0-0.80.9-0.20.40.6-0.4
Time in open arm after self-admin0.30.30.8-0.90.80.70.10.3-0.2-0.3-0.50.5-0.60.20.70.70.2
Bone: periosteal estimation0.40.91.6-1.21.31.1-0.30.80.1-0.8-1.11.0-0.90.81.20.81.2
Bone: periosteal perimeter1.62.84.4-2.02.12.0-0.71.60.6-1.6-1.91.8-1.61.51.91.12.0
Bone: post-yield work0.81.24.0-1.11.41.10.70.4-0.7-0.5-1.20.9-0.50.41.92.01.2
Progressive ratio test 1 active lever presses0.91.12.41.4-1.2-1.60.5-1.0-0.91.01.2-1.01.0-0.9-1.1-0.5-1.0
Progressive ratio test 1 breakpoint0.91.02.41.4-1.1-1.50.5-0.9-0.80.91.1-1.00.9-0.8-1.2-0.6-1.0
Progressive ratio test 1 inactive lever presses0.30.51.90.8-0.7-0.8-0.60.00.30.00.6-0.50.50.1-1.1-1.4-0.8
Progressive ratio test 2 active lever presses1.82.13.11.5-1.4-1.61.6-1.7-1.61.71.5-1.61.6-1.7-0.80.3-0.8
Progressive ratio test 2 breakpoint1.92.13.11.4-1.3-1.61.7-1.8-1.71.71.5-1.61.6-1.7-0.70.5-0.7
Progressive ratio test 2 inactive lever presses1.01.62.91.5-1.7-1.50.2-1.2-0.31.21.5-1.41.2-1.1-1.4-0.8-1.3
Incentive Sensitization - Responses1.11.64.40.7-0.7-0.72.1-1.6-1.81.50.9-1.21.3-1.60.21.40.1
Incentive Sensitization - Breakpoint1.41.85.00.7-0.7-0.72.2-1.7-1.91.60.9-1.31.3-1.70.41.60.1
Sum of active levers in priming session hrs 5-61.71.62.71.1-1.2-1.11.6-1.5-1.51.51.1-1.51.7-1.5-0.30.8-0.6
Progressive ratio0.10.10.5-0.00.2-0.00.4-0.3-0.70.30.1-0.40.3-0.30.10.3-0.2
Food seeking constrained by brief footshock1.82.24.81.2-1.0-1.22.2-1.7-2.11.71.1-1.41.7-1.70.11.5-0.8
Seeking ratio, punishment vs. effort0.20.40.70.7-0.7-0.70.9-0.7-0.60.70.6-0.40.6-0.6-0.20.4-0.2
Retroperitoneal fat weight0.31.26.00.9-0.6-0.6-1.60.91.0-0.80.30.4-0.11.0-1.7-2.5-0.7
Reaction time number correct0.00.10.6-0.0-0.0-0.00.20.2-0.1-0.2-0.10.8-0.60.20.00.10.3
Reaction time mean minus median1.74.36.5-1.92.02.0-2.22.62.1-2.5-2.22.3-2.32.51.2-0.41.8
Reaction time mean minus median AUC1.94.97.9-1.92.02.0-2.32.82.3-2.8-2.42.5-2.52.81.2-0.51.9
Reaction time num false alarms0.10.10.4-0.60.50.4-0.30.10.1-0.0-0.10.2-0.1-0.00.2-0.10.0
Reaction time num false alarms AUC0.10.10.3-0.50.30.30.2-0.4-0.40.40.1-0.10.1-0.40.30.4-0.0
Reaction time trials correct on left0.00.10.6-0.0-0.0-0.00.20.2-0.1-0.2-0.10.8-0.60.20.00.10.3
Reaction time trials on left0.10.10.7-0.0-0.1-0.00.10.30.0-0.3-0.10.8-0.60.3-0.0-0.10.3
Reaction time mean2.13.46.0-1.91.91.9-2.32.22.5-2.1-1.91.6-1.82.11.0-0.51.1
Reaction time mean AUC2.84.57.4-2.22.12.2-2.62.52.7-2.5-2.21.9-2.02.41.2-0.51.3
Median of all reaction times1.82.54.8-1.81.71.8-2.01.82.2-1.8-1.71.3-1.51.71.0-0.30.8
Reaction time omissions1.82.77.9-0.90.70.9-2.81.92.7-1.8-1.01.5-1.41.8-0.5-2.1-0.6
Reaction time false alarm rate0.10.10.3-0.30.20.10.1-0.4-0.30.50.2-0.50.4-0.50.10.2-0.2
Reaction time premature initiation rate0.40.52.7-0.0-0.10.1-1.30.51.6-0.5-0.10.3-0.50.5-0.4-0.9-0.3
Reaction time premature initiations0.30.52.3-0.20.00.2-1.10.61.5-0.6-0.30.7-0.90.7-0.2-0.7-0.0
Std. dev. reaction times3.05.58.1-2.32.32.4-2.82.82.7-2.8-2.42.4-2.42.81.2-0.71.6
Reaction time trials completed0.10.10.7-0.0-0.1-0.00.10.30.0-0.3-0.10.8-0.60.3-0.0-0.10.3
Reaction time trials AUC0.00.10.30.2-0.3-0.30.3-0.0-0.2-0.00.10.6-0.30.1-0.2-0.10.1
Run reversals in cocaine runway, females0.10.10.30.5-0.5-0.4-0.40.10.1-0.10.10.3-0.50.2-0.5-0.5-0.1
Run reversals in cocaine runway, males0.00.00.2-0.20.30.1-0.20.1-0.0-0.10.0-0.20.10.1-0.2-0.4-0.0
Latency to leave start box in cocaine runway0.40.42.1-0.40.20.40.9-0.5-0.40.4-0.2-0.10.1-0.61.01.50.6
Latency to leave start box in cocaine runway, F0.10.10.5-0.30.30.30.40.1-0.0-0.1-0.30.4-0.30.00.60.70.7
Latency to leave start box in cocaine runway, M0.50.52.6-0.60.40.50.7-0.6-0.50.5-0.2-0.20.1-0.61.11.60.5
Std. dev. time between licks in bursts0.50.72.60.3-0.2-0.2-1.40.71.5-0.60.00.00.00.7-0.9-1.6-0.6
Total sessions with >9 infusions0.70.91.31.1-1.0-1.10.9-1.0-0.71.01.0-1.11.1-0.9-0.8-0.3-0.8
Short access day 1 total inactive lever presses0.40.51.00.3-0.4-0.31.0-0.9-1.00.90.5-0.60.7-0.90.20.8-0.3
Short access day 10 total inactive lever presses0.41.02.9-0.40.40.6-1.71.31.6-1.2-0.61.0-0.61.3-0.4-1.40.1
Short access day 1 total infusions0.50.61.30.9-0.9-1.00.0-0.50.20.60.9-0.70.8-0.5-1.1-1.0-1.1
Short access day 10 total infusions1.31.62.71.1-1.4-1.31.2-1.6-1.01.61.5-1.31.2-1.6-0.90.1-1.1
Short access total infusions0.40.60.90.8-0.7-0.90.7-0.9-0.50.90.8-0.90.9-0.8-0.50.0-0.7
Short access day 1 locomotion0.50.63.60.5-0.5-0.5-0.90.30.8-0.20.5-0.20.30.3-1.4-1.9-0.8
Short access day 10 total locomotion0.61.12.11.4-1.2-1.40.8-0.9-0.70.91.2-1.01.1-0.9-1.1-0.5-0.8
Short access total locomotion0.91.01.71.3-1.1-1.31.1-1.0-1.00.91.1-1.11.1-0.9-0.9-0.2-0.7
One hour access (0.3 mA shock)0.91.01.81.2-1.0-1.10.7-1.2-0.91.21.1-1.31.3-1.2-0.60.2-0.6
Compulsive drug intake0.10.10.30.40.0-0.30.50.3-0.6-0.4-0.20.10.00.4-0.0-0.10.4
One hour access (shock baseline)0.71.02.10.7-0.8-0.70.7-1.4-0.81.41.0-1.41.3-1.5-0.20.6-0.6
Social response proportion0.20.20.60.2-0.4-0.1-0.50.00.70.00.3-0.20.20.0-0.6-0.8-0.7
Social responses0.70.93.90.3-0.4-0.1-1.50.82.0-0.7-0.10.20.10.8-0.9-1.7-0.8
Social time0.30.41.40.4-0.4-0.3-1.00.41.0-0.40.10.3-0.30.4-0.8-1.2-0.6
Soleus weight7.121.045.53.7-3.7-3.96.7-5.7-6.55.53.9-4.24.3-5.6-0.53.9-1.8
Bone: stiffness1.62.63.5-1.71.91.8-1.31.91.2-1.9-1.81.8-1.51.81.20.11.4
Tibialis anterior weight1.65.57.42.5-2.6-2.52.2-2.7-2.22.72.6-2.52.6-2.7-1.60.1-2.0
Time to tail flick, vehicle, before self-admin0.40.42.00.00.2-0.00.9-0.0-0.8-0.1-0.50.1-0.10.01.01.40.6
Time to tail flick, vehicle, after self-admin0.40.51.7-0.50.70.30.80.2-0.9-0.3-0.70.5-0.40.31.11.31.1
Time to tail flick, test, before self-admin1.11.22.31.5-1.1-1.31.2-1.0-0.91.01.0-1.31.4-1.0-0.70.1-0.9
Time to tail flick, test, after self-admin1.81.93.91.3-1.5-1.21.6-1.6-1.11.51.0-1.72.0-1.50.01.3-1.0
Delta time to tail flick, vehicle, before/after SA0.20.20.90.2-0.5-0.4-0.4-0.00.40.10.4-0.30.2-0.0-0.9-1.0-0.4
Delta time to tail flick, test, before/after SA0.10.10.3-0.0-0.5-0.10.0-0.30.10.30.2-0.30.4-0.4-0.10.2-0.3
Tibia length0.10.20.4-0.50.50.50.10.2-0.1-0.2-0.40.5-0.30.20.60.50.6
Ambulatory time before self-admin0.50.72.11.5-1.0-1.20.3-0.3-0.40.40.8-0.90.6-0.3-1.1-0.9-0.7
Ambulatory time after self-admin0.10.10.4-0.40.50.40.3-0.0-0.60.0-0.20.3-0.4-0.00.30.40.7
Bone: tissue strength0.70.72.2-0.50.50.41.5-0.7-1.40.60.0-0.30.5-0.80.81.30.6
Total heroin consumption0.81.02.01.0-0.9-1.01.1-1.1-0.81.10.9-1.31.4-1.1-0.40.3-0.6
Bone: trabecular number0.20.30.60.7-0.7-0.70.5-0.4-0.70.40.5-0.20.7-0.3-0.40.0-0.3
Bone: trabecular spacing0.10.10.40.2-0.0-0.20.6-0.4-0.60.40.3-0.6-0.0-0.40.00.30.2
Bone: trabecular thickness0.30.30.50.4-0.7-0.50.2-0.6-0.30.70.7-0.60.7-0.6-0.6-0.3-0.5
Bone: trabecular tissue density0.40.53.00.4-0.3-0.3-1.00.40.9-0.30.3-0.1-0.10.4-1.2-1.7-0.5
Water consumed over 24 hours0.30.30.90.5-0.7-0.50.5-0.6-0.40.60.7-0.70.9-0.6-0.6-0.3-0.4
Number of responses in last shaping day1.82.03.21.8-1.3-1.71.6-1.4-1.61.41.3-1.51.6-1.3-0.80.3-1.1