Hgf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Hgf	0.63	0.15	2.7e-13	0.45	0.47	0.47	0.48	2.7e-12	7.9e-13	9.0e-13	3.8e-13
2	Brain	alternative polyA	XM_039107017.1	0.03	0.02	1.5e-03	0.04	0.02	0.03	0.04	2.7e-04	3.1e-03	3.5e-04	2.9e-04
3	Liver	gene expression	Hgf	0.03	0.02	1.9e-04	0.01	0.02	0.01	0.01	1.3e-02	6.0e-03	9.2e-03	1.6e-02
4	Adipose	gene expression	Hgf	0.13	0.07	1.0e-12	0.09	0.09	0.09	0.09	8.5e-10	1.0e-09	6.5e-10	4.5e-10
5	PL	gene expression	Hgf	0.37	0.13	0.0e+00	0.37	0.39	0.4	0.4	4.1e-43	1.7e-45	2.4e-46	9.3e-47
6	PL	mRNA stability	Hgf	0.04	0.03	3.3e-04	0.04	0.03	0.03	0.03	5.4e-05	1.0e-04	3.7e-04	1.6e-04
7	Adipose	mRNA stability	Hgf	0.08	0.05	2.0e-05	0.03	0.03	0.02	0.02	8.2e-04	3.0e-04	2.8e-03	2.6e-03
8	Brain	gene expression	Hgf	0.16	0.08	1.8e-07	0.06	0.07	0.06	0.06	4.7e-06	3.4e-07	2.2e-06	4.4e-06
9	NAcc	gene expression	Hgf	0.1	0.06	4.2e-05	-0	0.04	0.03	0.02	8.4e-01	5.3e-05	9.6e-05	1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.3	0.5	1.6	-1.3	0.9	-0.6	0.9	-0.6	0.5	0.5	-0.5	-0.0
Area under the delay curve	0.0	0.0	0.1	0.3	-0.2	0.2	-0.3	0.1	0.0	-0.1	0.1	-0.1
BMI with tail	0.3	0.9	2.1	-1.3	-1.1	0.3	0.8	-0.4	0.1	0.7	-1.2	-1.4
BMI without tail	1.1	2.3	7.2	-1.2	-2.1	0.6	0.9	-0.6	0.3	1.3	-2.0	-2.7
Body weight	0.2	0.6	1.9	-1.4	-0.0	-0.4	1.0	-0.7	0.6	0.7	-0.9	-0.6
Weight adjusted by age	1.0	1.2	2.2	-1.3	-0.1	-0.4	1.1	-1.0	0.9	1.2	-1.5	-1.4
Bone surface	0.2	0.4	1.0	0.1	0.5	0.2	-0.4	0.5	-0.7	-0.9	0.9	1.0
Bone volume	0.3	0.5	1.3	-1.0	1.1	-0.7	0.8	-0.6	0.5	0.3	-0.2	0.4
Breakpoint value in progressive ratio session	0.1	0.1	0.4	0.0	-0.2	-0.1	0.2	-0.3	0.4	0.5	-0.5	-0.6
Number of licking bursts	0.7	0.8	1.4	-0.8	1.1	-1.2	1.0	-1.0	1.1	0.8	-0.5	0.2
Context. condit. distance diff. score	0.5	0.6	1.3	0.6	-1.1	0.9	-0.7	0.8	-0.9	-0.6	0.4	-0.2
Locomotion velocity, session 1	1.0	1.1	1.9	-1.1	1.4	-1.4	1.1	-1.0	1.1	0.6	-0.2	0.8
Locomotion distance, session 1	2.1	2.7	9.2	-0.8	3.0	-1.8	0.9	-0.7	0.8	-0.4	1.1	2.8
Locomotion velocity, session 2	0.5	0.6	1.1	-1.1	0.4	-0.5	0.9	-0.8	0.7	0.9	-1.0	-0.7
Locomotion distance, session 2	0.4	0.6	1.6	-0.5	1.3	-1.0	0.6	-0.5	0.7	0.1	0.4	1.2
Locomotion velocity, session 3	0.8	0.9	1.4	-1.2	1.2	-1.2	1.1	-0.9	1.0	0.6	-0.3	0.6
Locomotion distance, session 3	0.2	0.2	0.7	-0.0	0.2	-0.1	-0.1	0.3	-0.1	-0.5	0.7	0.8
Stereotopy head waving bouts, day 3	0.9	1.0	1.8	-0.8	1.3	-1.3	1.0	-1.2	1.2	0.9	-0.6	0.3
Stereotopy head waving duration, day 3	0.9	1.1	2.8	-0.8	1.7	-1.4	0.9	-1.1	1.1	0.7	-0.3	0.8
Locomotion velocity, session 7	0.3	0.3	0.7	0.3	-0.0	0.2	-0.4	0.5	-0.4	-0.7	0.8	0.9
Locomotion distance, session 7	0.4	0.5	0.8	0.7	-0.4	0.6	-0.7	0.9	-0.8	-0.9	0.9	0.5
Stereotopy head waving bouts, day 7	3.5	3.9	5.6	-2.4	1.2	-2.2	2.3	-2.3	2.3	2.1	-1.8	-0.3
Stereotopy head waving duration, day 7	5.8	7.0	9.5	-3.1	1.7	-2.9	3.1	-3.1	3.0	2.9	-2.5	-0.6
Locomotion velocity, session 8	1.0	1.2	2.1	-1.2	1.4	-1.4	1.2	-1.0	1.2	0.6	-0.1	0.9
Locomotion distance, session 8	0.0	0.1	0.2	-0.1	-0.4	0.3	-0.1	0.2	-0.3	-0.2	0.1	-0.1
Degree of sensitization distance	1.1	1.1	1.9	1.2	-1.2	1.4	-1.2	1.1	-1.2	-0.8	0.4	-0.5
Degree of sensitization stereotypy	3.9	4.2	6.3	-2.5	0.9	-2.0	2.4	-2.4	2.2	2.3	-2.1	-0.9
Conditioned locomotion	0.3	0.3	0.7	0.8	-0.6	0.6	-0.7	0.6	-0.5	-0.4	0.4	-0.2
Cocaine response after cond. corrected	2.7	3.0	5.6	-2.4	1.0	-1.3	2.0	-1.9	1.5	1.9	-2.0	-1.2
Cocaine response after cond. not corrected	0.7	0.8	2.0	-1.4	0.8	-0.6	1.0	-0.9	0.7	0.9	-1.1	-0.6
Cocaine response before conditioning	2.1	2.6	3.7	1.9	-0.4	1.2	-1.8	1.8	-1.6	-1.9	1.9	1.3
Saline control response	0.3	0.4	1.1	1.0	-0.3	0.6	-0.8	0.7	-0.5	-0.5	0.4	-0.0
Bone: connectivity density	0.1	0.2	0.8	-0.6	0.9	-0.1	0.2	0.1	-0.3	-0.4	0.4	0.7
Bone: cortical apparent density	0.2	0.3	0.8	-0.9	0.4	-0.4	0.6	-0.5	0.4	0.4	-0.5	-0.1
Bone: cortical area	1.2	1.8	2.5	1.6	-0.6	1.3	-1.5	1.5	-1.5	-1.5	1.4	0.6
Bone: cortical porosity	3.2	3.5	5.4	2.3	-0.3	1.5	-2.2	2.1	-2.0	-2.2	2.2	1.4
Bone: cortical porosity	5.5	6.0	9.1	3.0	-1.6	2.5	-2.9	2.8	-2.7	-2.6	2.3	0.7
Bone: cortical thickness	0.5	0.8	1.1	1.1	-0.7	1.0	-1.0	1.0	-1.0	-0.8	0.6	-0.1
Bone: cortical thickness	1.5	1.7	2.5	1.4	-0.2	1.1	-1.4	1.4	-1.5	-1.6	1.5	0.9
Bone: cortical tissue density	0.3	0.3	1.0	-1.0	0.4	-0.4	0.7	-0.5	0.4	0.5	-0.6	-0.2
Condit. Reinf. active minus inactive responses	0.7	0.8	1.2	-0.9	1.0	-1.1	1.0	-1.1	1.1	0.9	-0.7	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.4	0.7	-0.6	0.5	-0.6	0.6	0.4	-0.3	0.2
Condit. Reinf. active responses	0.7	0.9	1.6	-0.9	1.2	-1.2	1.0	-1.0	1.1	0.8	-0.5	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.4	0.7	-0.8	0.5	-0.5	0.6	0.3	-0.0	0.5
Incentive salience index mean	0.4	0.4	1.3	-0.5	1.1	-0.9	0.5	-0.6	0.6	0.2	-0.0	0.8
Condit. Reinf. lever presses	0.9	1.3	4.9	0.6	1.5	-0.5	-0.4	0.3	-0.1	-1.0	1.5	2.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	0.2	-0.4	-0.0	-0.3	0.4	0.2	0.0	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.5	0.1	-0.1	-0.3	-0.0	0.0	-0.1	0.2	0.3
Condit. Reinf. active responses	0.2	0.3	0.6	-0.3	-0.1	-0.6	0.5	-0.7	0.7	0.8	-0.7	-0.4
Condit. Reinf. inactive responses	1.1	1.4	2.7	-1.2	-0.3	-0.6	1.1	-1.2	1.0	1.5	-1.7	-1.4
Condit. Reinf. lever presses	2.6	3.6	5.1	-2.3	0.9	-1.7	2.1	-2.1	2.0	2.2	-2.1	-1.1
Condit. Reinf. lever reinforcers received	0.5	0.7	1.2	-0.6	0.1	-0.8	0.8	-1.0	1.0	1.1	-1.0	-0.5
Conditioned reinforcement - actives	0.5	0.5	1.6	-0.1	1.1	-0.7	0.4	-0.4	0.3	-0.3	0.7	1.3
Conditioned reinforcement - inactives	0.1	0.2	0.8	-0.1	0.9	-0.4	0.2	-0.2	0.2	-0.1	0.4	0.4
Conditioned locomotion	0.1	0.1	0.2	-0.3	0.5	-0.2	0.2	-0.2	0.0	-0.1	0.1	0.3
Patch foraging indifference point 0 sec	0.9	1.4	2.9	-1.3	-0.5	-0.4	1.1	-1.0	0.9	1.4	-1.7	-1.7
Patch foraging indifference point AUC	0.3	0.3	0.9	-0.7	0.8	-0.3	0.4	-0.2	-0.2	-0.4	0.4	0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.6	-0.3	0.2	0.3	-0.3	0.1	0.2	-0.5	-0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.2	0.0	-0.2	0.1	-0.2	0.3	0.4	-0.4	-0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	0.4	-0.1	0.3	-0.4	0.3	-0.4	-0.6	0.7	0.5
Delay disc. indifference point, 24s delay	0.3	0.3	0.7	0.6	0.7	-0.3	-0.4	0.2	0.1	-0.4	0.6	0.8
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.2	-0.1	0.2	-0.2	0.1	-0.2	-0.3	0.4	0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	0.7	-0.2	0.1	-0.6	0.3	0.0	-0.1	0.2	0.0
Indifference point function ln k	0.1	0.1	0.2	0.5	-0.5	0.4	-0.4	0.3	-0.2	-0.1	-0.1	-0.3
Indifference point function log k	0.1	0.1	0.2	0.5	-0.5	0.4	-0.4	0.3	-0.2	-0.1	-0.1	-0.3
Patch foraging total patch changes 0 sec	1.1	1.8	3.6	-1.5	-0.6	-0.4	1.2	-1.2	0.9	1.6	-1.9	-1.9
Patch foraging total patch changes 12 sec	0.1	0.2	0.9	-0.9	0.3	-0.2	0.6	-0.4	-0.1	-0.0	-0.2	0.2
Patch foraging total patch changes 18 sec	2.1	2.6	5.2	-2.3	1.2	-1.6	2.0	-1.8	1.5	1.6	-1.5	-0.3
Patch foraging total patch changes 24 sec	1.0	1.2	3.1	-1.8	1.0	-1.0	1.4	-1.2	0.8	0.8	-0.9	-0.0
Patch foraging total patch changes 6 sec	4.1	6.1	8.9	-3.0	0.6	-2.0	2.8	-2.7	2.6	2.9	-2.9	-1.8
Patch foraging time to switch 0 sec	0.3	0.4	1.0	-0.1	0.9	-0.9	0.5	-0.6	1.0	0.4	0.1	0.6
Patch foraging water rate 0 sec	0.3	0.4	1.2	0.3	-0.2	0.7	-0.5	0.6	-1.1	-0.9	0.6	0.4
Patch foraging water rate 12 sec	1.2	1.8	3.5	-1.1	1.9	-1.8	1.3	-1.5	1.5	1.0	-0.6	0.8
Patch foraging water rate 18 sec	0.8	1.1	2.9	-0.6	1.7	-1.5	0.8	-1.0	1.1	0.5	-0.1	1.2
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.6	0.4	-0.3	0.4	-0.4	0.1	-0.0	-0.1	0.4
Patch foraging water rate 6 sec	0.3	0.4	1.4	0.5	0.8	-0.2	-0.5	0.2	-0.3	-0.7	0.8	1.2
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	3.0	1.7	0.0	0.6	-1.3	1.1	-1.2	-1.5	1.7	1.4
Distance traveled before self-admin	0.7	0.8	1.9	-1.1	1.4	-1.0	0.9	-1.0	0.7	0.4	-0.3	0.6
Distance traveled after self-admin	0.3	0.3	0.7	0.3	0.7	-0.1	-0.5	0.4	-0.2	-0.6	0.7	0.9
Extensor digitorum longus weight	0.1	0.3	0.6	0.5	-0.8	0.6	-0.5	0.4	-0.4	-0.1	-0.1	-0.6
Bone: elastic displacement	0.9	1.0	1.6	1.0	-0.7	1.2	-1.1	1.3	-1.2	-1.0	0.9	0.0
Bone: elastic work	0.4	0.5	1.1	0.6	0.2	0.3	-0.6	0.8	-0.6	-0.9	1.1	0.9
Bone: endosteal estimation	0.1	0.1	0.4	0.0	0.4	-0.4	0.2	-0.2	0.3	-0.1	0.3	0.7
Bone: endosteal perimeter	0.7	1.4	2.6	1.1	0.1	0.8	-1.1	1.1	-1.3	-1.6	1.5	1.3
Epididymis fat weight	0.8	1.9	3.1	-1.8	0.5	-1.1	1.6	-1.6	1.2	1.5	-1.6	-0.8
Delta time in closed arm before/after self-admin	1.2	1.1	4.0	-0.1	1.6	-0.4	0.0	0.0	-0.4	-1.1	1.5	2.0
Delta time in open arm before/after self-admin	0.7	0.6	1.3	1.0	-1.1	0.9	-0.9	0.9	-0.7	-0.4	0.2	-0.5
Diff in mean of infusions in LGA sessions	1.1	1.2	2.1	-0.8	1.4	-1.4	1.2	-1.3	1.3	0.8	-0.3	0.7
Delay discount exponential model param	0.2	0.2	0.4	-0.6	0.2	-0.3	0.6	-0.4	0.2	0.4	-0.5	-0.2
Extinction: sum of active levers before priming	0.9	0.9	1.7	-1.0	1.1	-1.3	1.1	-1.1	1.0	0.8	-0.4	0.5
Active lever presses in extinction session 6	0.9	0.9	2.0	-0.3	1.3	-1.4	0.9	-1.0	1.1	0.6	0.1	0.9
Bone: final force	0.1	0.2	0.6	0.4	-0.8	0.6	-0.4	0.4	-0.4	-0.1	-0.0	-0.5
Bone: final moment	0.1	0.2	0.4	0.6	-0.6	0.6	-0.5	0.5	-0.5	-0.4	0.3	-0.1
Food consumed during 24 hour testing period	1.0	1.2	4.4	0.7	1.4	-0.5	-0.4	0.4	-0.1	-1.0	1.5	2.1
Glucose	0.2	0.3	0.6	0.3	0.5	0.1	-0.4	0.4	-0.4	-0.7	0.7	0.8
Heart weight	2.2	3.2	6.5	-1.2	2.5	-2.5	1.6	-1.9	2.2	1.2	-0.3	1.3
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.7	0.3	-0.4	0.6	-0.5	0.3	0.5	-0.5	-0.2
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.4	1.0	-0.8	0.5	-0.6	0.6	-0.1	0.4	1.0
Intermittent access intake escalation	0.3	0.3	1.0	-0.1	0.7	-0.4	0.1	-0.3	0.3	-0.3	0.6	1.0
Intermittent access intake escalation 2	0.9	0.9	2.5	0.9	0.5	0.1	-0.7	0.6	-0.5	-1.2	1.5	1.6
Intermitt. access day 1 inactive lever presses	2.2	2.4	4.6	1.4	-1.9	2.1	-1.6	1.6	-1.9	-1.2	0.7	-0.9
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	0.1	-0.7	0.6	-0.4	0.3	-0.2	0.0	-0.2	-0.9
Intermitt. access escalation Index	0.8	0.7	3.0	-0.3	-1.2	0.6	0.0	0.1	0.0	0.7	-1.1	-1.7
Intermittent access day 1 total infusions	1.2	1.4	2.0	-1.3	0.5	-1.0	1.3	-1.2	1.2	1.4	-1.4	-0.9
Intermittent access day 15 total infusions	0.9	1.0	1.7	-1.0	1.0	-1.2	1.0	-1.2	1.3	1.0	-0.6	0.1
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.9	-0.6	1.4	-1.2	0.7	-0.9	1.1	0.6	-0.1	0.7
Intermittent access total infusions	0.7	0.8	2.1	-0.6	1.4	-1.2	0.8	-0.9	0.9	0.5	-0.0	0.7
Intermittent access day 1 locomotion	1.1	1.1	2.0	-1.2	0.2	-0.8	1.1	-1.1	1.0	1.3	-1.4	-0.9
Intermittent access day 15 total locomotion	0.5	0.5	1.0	-0.6	0.9	-1.0	0.6	-0.8	0.8	0.5	-0.2	0.7
Intermittent access total locomotion	1.1	1.3	2.6	-0.9	1.6	-1.5	1.0	-1.2	1.2	0.8	-0.3	0.9
Intermittent access standard deviation	0.3	0.3	0.6	0.8	-0.4	0.5	-0.6	0.6	-0.5	-0.6	0.7	0.3
Left kidney weight	0.7	2.0	2.9	1.3	-0.8	1.4	-1.5	1.6	-1.7	-1.7	1.5	0.7
Right kidney weight	0.4	1.2	2.0	0.9	-1.4	1.4	-1.1	1.2	-1.4	-0.9	0.5	-0.5
Cocaine induced anxiety	1.3	1.5	2.2	1.3	-1.0	1.4	-1.4	1.5	-1.5	-1.2	1.0	0.1
Post-drug Anxiety	0.4	0.4	0.6	0.7	-0.3	0.6	-0.7	0.8	-0.7	-0.7	0.7	0.3
Baseline Anxiety	0.4	0.4	0.9	-0.8	-0.2	-0.2	0.7	-0.6	0.4	0.7	-0.9	-0.9
Tail length	0.2	0.5	1.7	-0.2	-1.3	0.5	0.2	-0.2	-0.1	0.5	-0.9	-1.3
Length with tail	0.0	0.0	0.1	0.2	-0.3	0.2	-0.1	0.1	-0.1	-0.0	-0.0	-0.2
Length without tail	0.2	0.5	1.3	0.5	1.1	-0.3	-0.4	0.3	-0.1	-0.5	0.9	1.2
Times rat made contact with spout	1.1	1.2	2.1	-1.4	0.1	-0.7	1.3	-1.1	1.0	1.3	-1.4	-1.1
Lifetime Intake	0.4	0.5	1.5	-0.5	1.2	-0.9	0.7	-0.7	0.6	0.3	0.0	0.5
Liver weight, left	0.4	0.7	1.2	0.7	0.5	0.4	-0.7	0.7	-0.8	-1.1	1.1	1.1
Liver weight, right	2.9	4.8	6.5	2.5	-1.0	2.1	-2.6	2.5	-2.4	-2.5	2.3	1.0
Locomotor activity	0.1	0.1	0.4	-0.4	0.6	-0.2	0.1	-0.1	-0.1	-0.2	0.2	0.5
Locomotor testing distance	0.3	0.4	1.5	-0.4	1.2	-0.6	0.2	-0.1	0.1	-0.3	0.6	1.1
Locomotor testing rearing	0.0	0.1	0.1	0.2	-0.0	0.2	-0.3	0.4	-0.1	-0.2	0.3	0.1
Locomotion in novel chamber	0.1	0.1	0.4	0.4	0.3	-0.2	-0.2	0.2	-0.0	-0.2	0.4	0.6
Locomotion in novel chamber post-restriction	1.1	1.3	2.0	-1.1	0.0	-0.8	1.3	-1.3	1.1	1.4	-1.3	-1.0
Fecal boli incidents, locomotor time 1	0.3	0.3	1.1	0.0	1.0	-0.5	0.2	-0.2	0.1	-0.2	0.5	0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.3	-0.2	0.2	0.3	-0.3	-0.2
Time >=10cm from walls, locomotor time 1	3.9	3.9	6.6	2.6	-1.2	1.8	-2.3	2.3	-2.1	-2.1	2.0	0.9
Bouts of movement, locomotor time 1	2.0	2.1	6.1	-1.3	-0.9	-0.1	1.0	-0.9	0.7	1.8	-2.3	-2.5
Total resting periods, locomotor time 1	1.9	2.1	5.8	-1.3	-0.8	-0.2	1.0	-0.9	0.7	1.8	-2.3	-2.4
Rest time, locomotor task time 1	1.1	1.2	1.9	-1.4	0.9	-1.0	1.2	-1.1	1.0	1.2	-1.2	-0.5
Distance moved, locomotor task time 1	5.2	5.7	8.4	2.9	-1.3	2.3	-2.7	2.7	-2.6	-2.7	2.5	1.2
Vertical activity count, locomotor time 1	1.5	1.6	2.1	1.4	-0.7	1.2	-1.4	1.4	-1.4	-1.5	1.3	0.6
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.8	1.3	0.2	0.4	-0.9	0.9	-0.8	-1.0	1.2	0.9
Bouts of movement, locomotor time 2	0.4	0.4	1.8	-0.2	-0.8	0.6	-0.1	0.2	-0.3	0.4	-0.8	-1.3
Total resting periods, locomotor time 2	0.3	0.3	1.4	-0.4	-0.5	0.3	0.1	-0.0	-0.1	0.5	-0.9	-1.2
Rest time, locomotor task time 2	0.1	0.2	0.3	0.3	-0.4	0.5	-0.6	0.5	-0.4	-0.3	0.2	-0.2
Distance moved, locomotor task time 2	0.3	0.3	0.6	0.8	-0.5	0.6	-0.6	0.7	-0.7	-0.5	0.4	0.0
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.1	-0.8	0.6	-0.1	0.3	-0.6	-0.2	-0.0	-0.5
Light reinforcement 1	0.7	1.3	2.6	-1.6	0.8	-1.0	1.4	-1.3	1.0	1.2	-1.2	-0.5
Light reinforcement 2	0.2	0.2	0.3	0.6	0.1	0.5	-0.5	0.5	-0.5	-0.6	0.5	0.3
Bone: marrow area	0.1	0.1	0.4	0.0	0.4	-0.4	0.2	-0.2	0.2	-0.1	0.3	0.6
Bone: maximum diameter	4.2	7.7	11.5	3.0	-1.1	2.5	-3.0	3.1	-3.1	-3.4	3.1	1.8
Bone: maximum force	0.6	1.1	1.4	1.1	-0.9	1.2	-1.1	1.1	-1.2	-1.1	0.9	0.2
Bone: maximum moment	0.8	1.4	1.8	1.3	-0.8	1.1	-1.3	1.3	-1.3	-1.3	1.3	0.5
Mean time between licks in bursts	0.5	0.7	2.1	-0.7	-0.5	-0.1	0.7	-0.6	0.6	1.1	-1.2	-1.4
Mean num. licks in bursts	0.1	0.2	0.5	-0.2	-0.7	0.5	-0.1	0.2	-0.4	0.0	-0.3	-0.7
Cd content in liver	1.0	1.0	1.9	-1.4	0.7	-0.9	1.2	-1.2	1.0	1.0	-1.1	-0.4
Co content in liver	0.6	0.7	2.1	-0.8	1.4	-0.8	0.7	-0.6	0.3	-0.2	0.4	1.2
Cu content in liver	0.6	0.7	1.5	-0.7	0.0	-0.3	0.7	-0.8	0.6	1.0	-1.2	-1.2
Fe content in liver	0.3	0.3	0.5	-0.7	0.7	-0.5	0.7	-0.6	0.6	0.6	-0.5	-0.2
K content in liver	0.8	0.8	1.8	0.6	-1.1	1.3	-0.9	0.9	-1.0	-0.4	-0.1	-1.1
Mg content in liver	0.8	0.8	3.5	0.1	-1.2	1.0	-0.3	0.2	-0.5	0.4	-1.0	-1.9
Mn content in liver	1.9	2.2	8.2	-1.0	-1.7	0.7	0.6	-0.5	0.1	1.3	-2.1	-2.9
Na content in liver	0.3	0.3	1.1	0.1	-1.0	0.6	-0.2	0.2	-0.2	0.2	-0.5	-1.0
Rb content in liver	1.2	1.5	3.2	-1.8	1.2	-0.9	1.5	-1.4	0.9	1.1	-1.3	-0.6
Se content in liver	2.6	3.2	12.1	-1.3	-2.0	0.7	0.8	-0.7	0.3	1.7	-2.6	-3.5
Sr content in liver	0.1	0.1	0.1	0.0	-0.1	0.3	-0.2	0.3	-0.4	-0.3	0.1	0.1
Zn content in liver	0.2	0.2	1.0	-0.2	-0.2	0.2	0.1	-0.2	0.1	0.5	-0.7	-1.0
Bone: minimum diameter	0.7	1.3	1.9	1.3	-0.2	1.0	-1.3	1.2	-1.2	-1.4	1.3	0.8
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.7	0.1	-0.2	0.4	-0.2	-0.0	-0.0	-0.1	0.3
Time in novel zone, hab. session 1	1.4	1.3	3.1	1.8	-1.0	1.1	-1.5	1.3	-1.0	-1.0	1.0	0.1
Total zone transitions, hab. session 1	0.6	0.8	2.8	-0.0	1.4	-0.2	-0.1	0.2	-0.5	-1.0	1.1	1.7
Total locomotion distance, hab. session 1	1.0	1.4	2.4	1.1	-0.2	1.2	-1.3	1.3	-1.5	-1.5	1.3	0.7
Locomotion velocity, hab. session 1	0.4	0.6	1.2	0.5	0.2	0.7	-0.7	0.8	-1.0	-1.1	0.9	0.7
Time in familiar zone, hab. session 2	0.3	0.4	0.6	0.4	-0.7	0.7	-0.6	0.7	-0.7	-0.6	0.5	-0.0
Time in novel zone, hab. session 2	0.7	0.7	1.4	-0.6	0.8	-1.2	0.8	-1.0	1.1	0.8	-0.5	0.3
Total zone transitions, hab. session 2	0.1	0.1	0.5	-0.1	-0.5	0.5	-0.0	0.1	-0.2	0.1	-0.4	-0.7
Total locomotion distance, hab. session 2	1.1	1.4	2.9	1.0	-1.3	1.7	-1.2	1.3	-1.6	-1.0	0.4	-0.7
Locomotion velocity, hab. session 2	0.9	1.2	2.6	0.8	-1.0	1.6	-1.1	1.3	-1.5	-1.0	0.5	-0.5
Novel to familiar place preference ratio	0.6	0.6	2.5	-0.2	-0.8	0.3	0.2	-0.3	0.2	0.8	-1.1	-1.6
Novelty place preference	0.7	0.7	2.9	-0.2	-1.0	0.4	0.1	-0.2	0.1	0.8	-1.1	-1.7
Time in novel zone, NPP test	0.6	0.6	2.4	-0.1	-1.0	0.4	0.1	-0.1	0.1	0.7	-1.0	-1.6
Total zone transitions, NPP test	0.6	0.9	2.7	-0.9	1.6	-1.1	1.0	-0.8	0.8	0.3	0.1	0.9
Total locomotion distance, NPP test	0.4	0.5	0.9	0.7	-0.5	0.9	-0.7	0.8	-0.9	-0.8	0.6	-0.0
Locomotion velocity, NPP test	0.4	0.6	1.2	0.7	-0.5	1.1	-0.8	1.0	-1.1	-0.8	0.6	-0.1
Intraocular pressure	0.6	0.8	2.0	-0.6	1.4	-1.2	0.8	-0.8	0.9	0.5	-0.1	0.9
Delta distance traveled before/after self-admin	1.6	1.7	2.6	1.5	-0.6	1.2	-1.6	1.6	-1.4	-1.4	1.4	0.6
Delta ambulatory time before/after self-admin	1.5	1.6	2.7	1.5	-1.6	1.5	-1.4	1.4	-1.3	-0.9	0.6	-0.7
Parametrial fat weight	0.4	0.7	1.8	0.4	-0.6	1.1	-0.8	0.9	-1.3	-1.1	0.6	0.1
Pavlov. Cond. lever latency	1.0	1.2	3.2	-0.9	-0.6	-0.3	0.9	-0.9	0.8	1.4	-1.5	-1.8
Pavlov. Cond. magazine entry latency	1.8	2.3	4.4	2.1	-0.4	0.9	-1.7	1.6	-1.2	-1.7	1.9	1.4
Pavlov. Cond. change in total contacts	0.7	0.7	1.1	1.0	-0.2	0.5	-0.9	0.8	-0.7	-1.0	1.1	0.9
Pavlov. Cond. index score	1.5	1.9	3.5	1.6	0.2	0.6	-1.4	1.3	-1.0	-1.7	1.9	1.8
Pavlov. Cond. latency score	1.1	1.4	2.7	1.3	0.2	0.4	-1.2	1.0	-0.9	-1.5	1.6	1.6
Pavlov. Cond. lever contacts	1.6	1.9	3.1	1.5	-0.2	0.9	-1.4	1.4	-1.3	-1.8	1.7	1.5
Pavlov. Cond. magazine entry number	1.5	1.8	3.3	-1.8	0.2	-0.8	1.5	-1.3	1.1	1.6	-1.7	-1.3
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.8	-0.5	-1.2	0.6	0.2	-0.1	-0.0	0.7	-1.0	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	3.8	1.7	0.1	0.8	-1.5	1.5	-1.2	-1.8	1.9	1.7
Pavlov. Cond. response bias	3.0	3.7	5.5	2.3	-0.4	1.4	-2.1	2.1	-1.8	-2.3	2.3	1.7
Pavlov. Cond. lever latency	0.6	0.8	1.2	1.1	-0.4	0.7	-1.0	1.0	-0.9	-1.1	1.0	0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.0	0.1	-0.2	0.2	-0.2	0.4	0.3	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.5	0.8	1.1	-1.0	0.5	-0.7	1.0	-1.0	0.8	1.0	-1.0	-0.6
Pavlov. Cond. index score	0.4	0.5	0.8	-0.9	0.6	-0.7	0.9	-0.8	0.8	0.8	-0.6	-0.2
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.7	0.7	-0.7	0.7	-0.7	0.7	0.5	-0.4	0.0
Pavlov. Cond. lever contacts	1.2	1.6	2.4	-1.6	0.5	-1.0	1.4	-1.4	1.2	1.5	-1.5	-0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.0	-0.0	-0.0	-0.1	0.1	0.3
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.4	1.5	-0.5	0.5	-1.2	1.0	-0.7	-1.1	1.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.9	0.7	-0.8	0.9	-0.8	0.9	0.8	-0.6	-0.2
Pavlov. Cond. response bias	1.0	1.3	2.0	-1.3	0.3	-0.9	1.3	-1.2	1.2	1.4	-1.3	-0.9
Time in closed arm before self-admin	0.6	0.7	2.0	1.0	-1.4	1.0	-0.9	0.8	-0.5	-0.3	0.1	-0.7
Time in closed arm after self-admin	1.2	1.2	2.0	1.0	-0.6	1.1	-1.2	1.2	-1.2	-1.4	1.3	0.6
Time in open arm before self-admin	0.3	0.3	1.0	-0.3	1.0	-0.4	0.4	-0.4	-0.0	-0.4	0.5	1.0
Time in open arm after self-admin	0.4	0.5	1.3	0.8	0.5	-0.1	-0.5	0.5	-0.3	-0.7	0.9	1.2
Bone: periosteal estimation	0.4	0.7	1.1	1.0	-0.2	0.7	-0.9	0.9	-0.9	-1.1	1.1	0.7
Bone: periosteal perimeter	1.5	2.4	3.5	1.8	-0.6	1.4	-1.7	1.7	-1.7	-1.9	1.8	1.0
Bone: post-yield work	1.0	1.4	3.9	0.9	1.0	0.1	-0.8	0.8	-0.8	-1.4	1.7	2.0
Progressive ratio test 1 active lever presses	1.1	1.2	1.8	-1.3	0.6	-1.0	1.3	-1.4	1.2	1.1	-1.0	-0.4
Progressive ratio test 1 breakpoint	1.0	1.1	1.7	-1.2	0.6	-1.0	1.3	-1.3	1.1	1.1	-1.0	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.9	-0.2	-0.8	0.3	0.1	-0.2	0.0	0.3	-0.5	-1.0
Progressive ratio test 2 active lever presses	1.6	1.7	2.4	-1.4	1.4	-1.5	1.5	-1.6	1.5	1.2	-0.8	0.2
Progressive ratio test 2 breakpoint	1.5	1.7	2.6	-1.3	1.6	-1.6	1.5	-1.5	1.5	1.0	-0.6	0.5
Progressive ratio test 2 inactive lever presses	0.5	0.5	0.9	-0.8	0.6	-0.8	0.8	-0.9	0.9	0.7	-0.6	-0.2
Incentive Sensitization - Responses	1.0	1.0	2.1	-0.8	1.4	-1.3	1.0	-1.0	1.1	0.6	-0.1	0.8
Incentive Sensitization - Breakpoint	1.0	1.1	2.4	-0.8	1.6	-1.4	1.0	-1.0	1.1	0.5	-0.0	0.9
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.4	0.9	-0.6	0.4	-0.5	0.5	0.3	-0.1	0.3
Progressive ratio	0.2	0.3	0.5	-0.5	0.7	-0.7	0.6	-0.6	0.5	0.3	-0.0	0.4
Food seeking constrained by brief footshock	2.1	2.6	6.0	-1.8	2.5	-2.0	1.7	-1.5	1.5	0.6	-0.0	1.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.8	0.8	-0.6	0.5	-0.5	0.5	0.3	-0.2	0.3
Retroperitoneal fat weight	0.3	1.0	2.5	-1.3	-0.4	-0.1	0.9	-0.8	0.4	1.1	-1.6	-1.5
Reaction time number correct	0.0	0.0	0.1	-0.1	0.3	0.1	-0.1	0.2	-0.1	-0.1	-0.1	0.0
Reaction time mean minus median	2.9	3.8	6.6	1.8	-2.5	2.6	-2.0	2.1	-2.3	-1.7	1.0	-0.7
Reaction time mean minus median AUC	3.5	4.5	8.0	1.9	-2.7	2.8	-2.2	2.3	-2.5	-1.9	1.0	-0.8
Reaction time num false alarms	0.0	0.1	0.3	0.5	-0.4	0.1	-0.3	0.2	0.0	0.0	0.2	-0.2
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	0.3	-0.3	-0.1	-0.0	0.3	0.0	0.3	0.3
Reaction time trials correct on left	0.0	0.0	0.1	-0.1	0.3	0.1	-0.1	0.2	-0.1	-0.1	-0.1	0.0
Reaction time trials on left	0.0	0.0	0.1	-0.1	0.2	0.2	-0.1	0.2	-0.2	-0.1	-0.2	-0.1
Reaction time mean	2.1	2.9	5.3	1.8	-2.3	2.2	-1.7	1.7	-1.9	-1.3	0.9	-0.8
Reaction time mean AUC	2.9	3.9	6.6	2.0	-2.6	2.6	-2.0	2.1	-2.2	-1.6	1.1	-0.8
Median of all reaction times	1.5	2.0	3.6	1.6	-1.9	1.8	-1.5	1.4	-1.5	-1.1	0.9	-0.6
Reaction time omissions	1.7	2.3	7.6	0.8	-2.8	2.0	-1.0	1.2	-1.4	-0.4	-0.3	-1.9
Reaction time false alarm rate	0.0	0.1	0.2	0.3	0.1	-0.3	0.0	-0.2	0.4	0.2	0.2	0.1
Reaction time premature initiation rate	0.2	0.3	1.1	0.2	-0.7	0.5	-0.3	0.3	-0.2	0.2	-0.4	-1.0
Reaction time premature initiations	0.2	0.2	0.7	0.3	-0.5	0.6	-0.5	0.5	-0.4	-0.0	-0.2	-0.8
Std. dev. reaction times	3.2	4.5	8.5	2.0	-2.9	2.8	-2.1	2.3	-2.4	-1.7	1.0	-1.0
Reaction time trials completed	0.0	0.0	0.1	-0.1	0.2	0.2	-0.1	0.2	-0.2	-0.1	-0.2	-0.1
Reaction time trials AUC	0.0	0.0	0.1	-0.4	0.4	-0.1	0.2	-0.0	0.1	0.1	-0.3	-0.1
Run reversals in cocaine runway, females	0.3	0.2	0.9	-0.2	-0.6	0.5	-0.2	0.2	-0.3	0.3	-0.7	-1.0
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	-0.5	0.2	-0.0	0.1	-0.1	0.1	-0.1	-0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.9	0.3	1.3	-0.6	-0.1	-0.0	0.1	-0.5	1.0	1.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.0	0.2	0.1	-0.1	0.1	-0.2	-0.2	0.2	0.2
Latency to leave start box in cocaine runway, M	0.6	0.5	1.5	0.7	0.8	-0.2	-0.5	0.4	-0.2	-0.7	1.1	1.2
Std. dev. time between licks in bursts	0.5	0.6	2.6	-0.3	-1.0	0.6	0.1	-0.1	-0.2	0.6	-1.0	-1.6
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.2	-0.1	0.3	-0.5	0.1	0.3	-0.3	-0.4
Short access day 1 total inactive lever presses	0.3	0.3	0.9	0.1	0.9	-0.3	-0.0	0.1	-0.3	-0.5	0.7	1.0
Short access day 10 total inactive lever presses	0.9	1.0	2.7	0.5	-1.6	1.3	-0.7	0.7	-0.9	-0.1	-0.4	-1.6
Short access day 1 total infusions	0.1	0.1	0.7	-0.2	-0.2	0.3	0.2	-0.1	-0.2	0.3	-0.4	-0.9
Short access day 10 total infusions	1.1	1.3	1.9	-1.2	1.0	-1.3	1.3	-1.2	1.4	1.2	-0.9	-0.2
Short access total infusions	0.0	0.0	0.1	0.3	0.1	0.2	-0.1	0.2	-0.3	-0.2	0.3	-0.1
Short access day 1 locomotion	0.6	0.6	1.9	0.5	-1.3	1.0	-0.5	0.4	-0.6	0.1	-0.4	-1.4
Short access day 10 total locomotion	1.2	1.3	1.9	-1.4	1.0	-1.3	1.2	-1.4	1.2	1.1	-1.0	0.1
Short access total locomotion	0.6	0.6	1.1	-0.9	0.5	-0.8	0.9	-1.1	0.8	0.9	-0.8	-0.2
One hour access (0.3 mA shock)	0.3	0.4	1.3	-0.4	1.1	-0.8	0.5	-0.6	0.6	0.1	0.2	0.8
Compulsive drug intake	0.1	0.1	0.5	-0.0	-0.3	0.5	-0.2	0.3	-0.7	-0.5	0.1	0.2
One hour access (shock baseline)	0.8	0.9	1.7	-0.7	1.3	-1.3	1.0	-1.0	1.3	0.7	-0.1	0.6
Social response proportion	0.1	0.1	0.5	0.0	-0.5	0.1	0.1	-0.2	0.1	0.4	-0.5	-0.7
Social responses	0.6	0.7	3.1	0.0	-1.2	0.9	-0.2	0.1	-0.4	0.4	-0.9	-1.7
Social time	0.2	0.3	1.1	-0.3	-0.6	0.5	-0.0	0.1	-0.2	0.3	-0.7	-1.1
Soleus weight	6.2	18.3	41.1	-3.9	6.4	-5.8	4.1	-4.2	4.4	2.2	-0.6	4.0
Bone: stiffness	1.5	2.4	3.4	1.7	-1.6	1.8	-1.7	1.8	-1.8	-1.6	1.2	-0.0
Tibialis anterior weight	1.6	5.6	8.1	-2.6	2.2	-2.9	2.6	-2.7	2.7	2.3	-1.8	0.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.9	-0.2	1.5	-0.8	0.3	-0.3	-0.0	-0.5	0.8	1.7
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	-0.1	0.5	0.1	-0.1	0.1	-0.2	-0.5	0.5	0.7
Time to tail flick, test, before self-admin	1.6	1.5	3.0	-1.5	1.7	-1.5	1.3	-1.4	1.2	0.7	-0.4	0.9
Time to tail flick, test, after self-admin	1.5	1.6	3.1	-1.1	1.8	-1.6	1.4	-1.3	1.4	0.8	-0.3	0.9
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	2.5	-0.5	-1.0	0.4	0.2	-0.2	0.2	0.7	-1.1	-1.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.2	0.0	-0.3	0.4	-0.4	0.6	0.6	-0.6	-0.5
Tibia length	0.0	0.1	0.3	0.1	0.3	0.1	-0.1	0.3	-0.2	-0.4	0.5	0.5
Ambulatory time before self-admin	0.7	0.7	1.3	-1.2	1.0	-0.9	0.9	-1.0	0.8	0.6	-0.5	0.2
Ambulatory time after self-admin	0.3	0.3	0.6	0.7	-0.3	0.5	-0.8	0.7	-0.5	-0.6	0.5	0.2
Bone: tissue strength	0.7	0.7	2.6	0.2	1.4	-0.9	0.2	-0.2	0.5	-0.3	0.9	1.6
Total heroin consumption	0.3	0.4	0.7	-0.7	0.9	-0.7	0.8	-0.8	0.6	0.4	-0.2	0.3
Bone: trabecular number	0.4	0.5	1.7	-1.3	1.0	-0.6	0.9	-0.6	0.4	0.4	-0.5	0.1
Bone: trabecular spacing	0.0	0.0	0.1	0.1	0.0	-0.3	0.1	-0.3	0.3	0.2	-0.0	0.1
Bone: trabecular thickness	0.6	0.7	1.0	-1.0	0.9	-0.8	0.9	-0.8	0.9	0.8	-0.7	-0.2
Bone: trabecular tissue density	0.6	0.8	2.9	-0.4	-1.4	0.6	0.2	-0.1	-0.0	0.6	-1.1	-1.7
Water consumed over 24 hours	0.0	0.1	0.3	-0.1	0.5	-0.3	0.2	-0.2	0.2	0.1	0.0	0.2
Number of responses in last shaping day	1.3	1.4	3.1	-1.8	1.2	-1.0	1.5	-1.4	0.9	0.8	-0.9	-0.1