Hub : Genes

Hgf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Hgf 0.05 0.04 7.0e-03 0.04 0.04 0.03 0.03 5.0e-03 3.8e-03 1.1e-02 6.8e-03
2 Adipose mRNA stability Hgf 0.07 0.04 4.7e-05 0.03 0.03 0.03 0.03 5.3e-04 3.7e-04 2.5e-04 7.7e-04
3 IL gene expression Hgf 0.6 0.14 4.4e-12 0.45 0.42 0.46 0.44 3.3e-12 2.3e-11 1.3e-12 6.8e-12
4 PL gene expression Hgf 0.37 0.12 0.0e+00 0.38 0.4 0.41 0.41 2.0e-43 4.8e-47 5.3e-48 1.0e-48
5 Brain alternative polyA NM_017017.2 0.02 0.02 5.8e-03 0.02 0.02 0.01 0.02 2.7e-03 8.5e-03 2.2e-02 7.6e-03
6 BLA alternative polyA XM_006235979.5 0.05 0.04 7.8e-03 0.01 0.02 0.01 0.01 6.0e-02 2.2e-02 9.0e-02 6.7e-02
7 Brain alternative polyA XM_006235979.5 0.02 0.01 8.2e-03 0.02 0.02 0.02 0.02 3.0e-03 9.8e-03 1.0e-02 4.9e-03
8 BLA alternative polyA NM_017017.2 0.06 0.05 2.7e-03 0.03 0.03 0 0.03 1.6e-02 6.2e-03 3.1e-01 1.5e-02
9 Adipose gene expression Hgf 0.14 0.07 1.9e-13 0.09 0.09 0.09 0.09 5.9e-10 1.7e-10 2.1e-10 2.0e-10
10 Liver gene expression Hgf 0.03 0.02 1.8e-04 0.03 0.02 0.01 0.01 8.4e-04 4.7e-03 6.5e-02 1.2e-02
11 BLA alternative polyA NM_017017.2 0.06 0.04 6.0e-03 0.05 0.03 0.03 0.03 1.9e-03 1.4e-02 1.8e-02 9.1e-03
12 PL mRNA stability Hgf 0.02 0.02 3.2e-03 0.02 0.02 0.01 0.02 3.7e-03 2.8e-03 5.4e-02 6.0e-03
13 Brain gene expression Hgf 0.16 0.08 3.0e-07 0.07 0.08 0.07 0.07 2.8e-07 1.1e-07 5.0e-07 7.6e-07
14 NAcc gene expression Hgf 0.09 0.05 1.5e-06 0 0.05 0.04 0.03 7.4e-02 1.4e-07 2.0e-07 1.5e-05
15 IC gene expression Hgf 0.66 0.15 2.0e-14 0.19 0.24 0.27 0.24 2.1e-08 1.2e-10 1.3e-11 1.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.30.6-0.5-0.70.7-0.7-0.2-0.30.50.30.50.3-0.6-0.3-0.6-0.40.3
Area under the delay curve0.00.00.20.10.5-0.20.10.10.1-0.3-0.1-0.1-0.10.20.10.1-0.0-0.1
BMI with tail0.00.10.30.3-0.3-0.2-0.10.40.5-0.0-0.5-0.3-0.3-0.20.6-0.1-0.4-0.1
BMI without tail0.10.30.70.80.2-0.30.30.90.7-0.7-0.7-0.4-0.30.30.7-0.0-0.5-0.6
Body weight0.00.10.4-0.3-0.40.2-0.2-0.3-0.10.60.10.10.1-0.4-0.1-0.10.1-0.1
Weight adjusted by age0.30.81.7-0.4-1.31.0-1.2-0.3-0.50.40.51.01.0-1.0-0.4-1.3-1.10.7
Bone surface0.20.40.90.10.5-0.50.5-0.10.50.4-0.5-0.7-0.90.40.50.80.8-1.0
Bone volume0.10.30.8-0.7-0.60.6-0.6-0.6-0.50.90.50.50.2-0.6-0.4-0.30.10.0
Breakpoint value in progressive ratio session0.50.91.9-0.5-0.91.1-0.8-0.1-0.9-0.01.01.11.3-1.4-1.0-1.0-0.71.1
Number of licking bursts0.30.81.3-1.0-0.60.9-0.8-0.8-1.10.61.11.01.0-1.0-1.1-0.50.20.9
Context. condit. distance diff. score0.50.71.00.90.7-0.80.80.71.0-0.5-1.0-0.8-1.00.91.00.4-0.2-1.0
Locomotion velocity, session 11.21.32.3-1.5-1.00.9-1.0-1.2-1.41.21.41.11.3-1.3-1.4-0.30.61.0
Locomotion distance, session 12.12.67.2-2.4-0.60.5-0.7-2.7-1.82.71.60.70.8-1.0-1.70.92.5-0.1
Locomotion velocity, session 20.50.61.4-0.5-1.10.7-0.9-0.1-0.60.30.60.80.8-0.9-0.5-0.9-0.71.2
Locomotion distance, session 20.50.71.4-1.2-0.30.4-0.4-1.1-1.11.01.00.50.7-0.9-1.10.31.10.6
Locomotion velocity, session 30.91.02.3-1.4-1.00.9-1.0-1.3-1.11.51.10.90.8-0.9-1.1-0.30.60.6
Locomotion distance, session 30.10.10.5-0.10.5-0.30.4-0.3-0.1-0.00.1-0.2-0.10.1-0.10.60.7-0.2
Stereotopy head waving bouts, day 31.11.32.8-1.3-0.91.1-1.1-1.4-1.31.71.31.11.2-0.9-1.3-0.60.30.3
Stereotopy head waving duration, day 31.01.23.6-1.5-0.70.9-0.8-1.5-1.31.91.30.90.9-0.7-1.3-0.20.80.0
Locomotion velocity, session 70.30.40.90.00.6-0.70.6-0.30.30.6-0.3-0.6-0.50.40.30.91.0-0.9
Locomotion distance, session 70.40.50.80.60.9-0.80.90.50.7-0.2-0.7-0.9-0.90.80.70.80.5-0.6
Stereotopy head waving bouts, day 74.45.17.2-2.4-2.72.5-2.6-1.6-2.41.92.42.42.7-2.5-2.3-1.8-0.32.3
Stereotopy head waving duration, day 75.97.310.2-2.7-3.13.0-3.0-1.9-2.82.02.83.03.2-3.1-2.8-2.3-0.62.8
Locomotion velocity, session 81.11.32.4-1.5-0.90.8-0.9-1.4-1.41.51.41.01.1-1.3-1.4-0.30.70.8
Locomotion distance, session 80.00.10.10.30.2-0.20.20.20.30.0-0.3-0.2-0.30.20.30.1-0.1-0.4
Degree of sensitization distance1.21.32.11.30.9-1.10.91.31.4-0.8-1.4-1.1-1.41.41.50.4-0.4-0.9
Degree of sensitization stereotypy3.84.26.8-1.8-2.52.3-2.4-0.8-2.01.02.02.22.5-2.5-1.9-2.0-0.92.6
Conditioned locomotion0.40.50.91.00.9-0.80.90.80.7-0.7-0.7-0.7-0.50.40.60.4-0.1-0.4
Cocaine response after cond. corrected1.52.34.4-1.2-2.12.0-2.0-0.6-1.30.91.31.81.4-1.5-1.2-2.0-1.21.5
Cocaine response after cond. not corrected0.40.61.3-0.7-1.11.0-1.0-0.5-0.60.70.60.80.3-0.6-0.5-0.9-0.50.7
Cocaine response before conditioning1.82.24.00.81.8-1.91.80.31.2-0.3-1.3-1.8-1.91.61.22.01.5-1.6
Saline control response0.40.50.80.80.9-0.90.90.70.7-0.6-0.7-0.7-0.70.80.60.50.0-0.3
Bone: connectivity density0.10.10.3-0.2-0.0-0.0-0.0-0.20.20.5-0.2-0.3-0.50.10.20.30.4-0.5
Bone: cortical apparent density0.10.20.5-0.6-0.70.5-0.7-0.7-0.40.70.30.40.3-0.1-0.3-0.30.0-0.0
Bone: cortical area1.42.33.31.41.8-1.81.70.81.5-0.7-1.5-1.7-1.71.81.51.50.7-1.7
Bone: cortical porosity2.72.95.11.22.0-1.92.00.61.5-0.4-1.6-2.0-2.12.31.52.01.2-2.0
Bone: cortical porosity5.25.79.12.32.8-2.62.81.72.5-1.6-2.5-2.6-2.83.02.42.10.7-2.4
Bone: cortical thickness0.71.22.11.31.3-1.21.31.21.2-0.9-1.2-1.1-1.31.51.10.7-0.1-0.9
Bone: cortical thickness1.82.13.60.91.8-1.61.80.91.3-1.0-1.3-1.7-1.81.91.31.81.2-1.2
Bone: cortical tissue density0.20.30.7-0.6-0.80.6-0.8-0.7-0.40.70.40.50.3-0.1-0.3-0.4-0.00.0
Condit. Reinf. active minus inactive responses0.80.91.8-1.0-1.01.0-1.0-1.1-1.11.41.11.01.0-1.1-1.1-0.7-0.00.4
Condit. Reinf. active-inactive response ratio0.30.30.9-0.7-0.50.4-0.5-0.7-0.71.00.70.60.6-0.7-0.7-0.30.20.2
Condit. Reinf. active responses0.81.12.3-1.2-0.80.9-0.9-1.4-1.21.51.21.01.0-1.1-1.2-0.50.40.3
Condit. Reinf. inactive responses0.20.30.7-0.7-0.00.3-0.2-0.9-0.70.80.70.50.5-0.4-0.80.00.5-0.1
Incentive salience index mean0.60.83.1-1.0-0.50.4-0.5-1.6-0.91.80.80.60.6-0.7-0.80.00.7-0.5
Condit. Reinf. lever presses0.91.34.3-0.90.6-0.70.4-2.1-0.52.00.4-0.3-0.10.1-0.51.42.1-1.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.30.10.2-0.0-0.4-0.50.20.50.40.3-0.2-0.6-0.10.20.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.10.30.10.2-0.0-0.1-0.10.10.0-0.0-0.0-0.20.10.2-0.2
Condit. Reinf. active responses0.20.30.6-0.4-0.50.7-0.6-0.3-0.60.30.60.80.5-0.5-0.6-0.7-0.40.6
Condit. Reinf. inactive responses0.71.12.5-0.4-1.41.2-1.30.0-0.70.20.81.21.0-0.9-0.7-1.6-1.31.4
Condit. Reinf. lever presses2.33.45.4-1.6-2.22.3-2.3-0.9-1.81.01.82.21.9-1.8-1.7-2.2-1.31.9
Condit. Reinf. lever reinforcers received0.50.81.2-0.7-0.91.1-0.9-0.5-1.00.51.01.10.9-0.9-1.0-1.0-0.60.9
Conditioned reinforcement - actives0.00.20.8-0.20.3-0.60.2-0.6-0.10.50.0-0.3-0.10.1-0.10.80.9-0.4
Conditioned reinforcement - inactives0.10.20.5-0.6-0.40.3-0.6-0.4-0.60.50.60.40.7-0.6-0.5-0.00.20.3
Conditioned locomotion0.10.10.30.00.1-0.40.1-0.50.20.6-0.3-0.3-0.40.30.20.40.4-0.6
Patch foraging indifference point 0 sec0.30.92.7-0.3-1.31.1-1.30.1-0.40.40.51.10.5-0.5-0.4-1.6-1.60.8
Patch foraging indifference point AUC0.10.10.6-0.3-0.3-0.0-0.1-0.70.10.4-0.2-0.3-0.2-0.30.20.50.8-0.2
Delay disc. indifference point, 0s delay0.10.10.30.1-0.40.0-0.6-0.00.20.2-0.20.10.3-0.20.3-0.4-0.50.3
Delay disc. indifference point, 16s delay0.10.10.3-0.3-0.20.5-0.30.1-0.2-0.50.20.40.2-0.1-0.2-0.4-0.30.2
Delay disc. indifference point, 2s delay0.10.20.70.20.4-0.80.2-0.20.30.2-0.3-0.50.2-0.00.30.70.6-0.4
Delay disc. indifference point, 24s delay0.10.20.7-0.50.7-0.00.1-0.7-0.40.50.3-0.0-0.10.2-0.40.50.8-0.4
Delay disc. indifference point, 4s delay0.10.10.30.20.4-0.60.30.10.3-0.2-0.3-0.4-0.00.10.30.50.3-0.1
Delay disc. indifference point, 8s delay0.00.10.6-0.00.8-0.10.20.0-0.1-0.10.10.0-0.30.4-0.10.00.00.0
Indifference point function ln k0.00.10.90.30.2-0.30.10.40.30.0-0.3-0.1-0.51.00.3-0.1-0.3-0.5
Indifference point function log k0.00.10.90.30.2-0.30.10.40.30.0-0.3-0.1-0.51.00.3-0.1-0.3-0.5
Patch foraging total patch changes 0 sec0.41.13.3-0.3-1.41.2-1.40.2-0.50.30.51.20.7-0.7-0.4-1.8-1.81.1
Patch foraging total patch changes 12 sec0.20.21.0-0.5-0.70.4-0.7-0.7-0.21.00.10.20.2-0.5-0.1-0.10.20.0
Patch foraging total patch changes 18 sec1.33.04.8-1.8-2.21.9-2.2-1.4-1.71.51.71.91.7-1.9-1.6-1.6-0.51.6
Patch foraging total patch changes 24 sec0.51.63.1-1.4-1.71.4-1.6-1.2-1.11.71.11.21.2-1.3-1.1-1.0-0.10.8
Patch foraging total patch changes 6 sec3.05.18.1-1.6-2.82.8-2.8-1.0-2.01.32.12.72.5-2.6-2.0-2.8-1.82.2
Patch foraging time to switch 0 sec0.10.30.8-0.60.20.20.1-0.6-0.80.30.80.40.8-0.5-0.90.30.70.2
Patch foraging water rate 0 sec0.10.30.80.2-0.0-0.60.0-0.40.60.9-0.7-0.6-0.70.50.70.50.3-0.8
Patch foraging water rate 12 sec0.62.64.7-2.0-1.51.6-1.4-2.2-1.91.91.91.61.5-1.4-1.9-0.80.50.9
Patch foraging water rate 18 sec1.02.36.6-2.0-1.21.0-1.2-2.4-1.82.61.71.31.1-1.1-1.7-0.31.00.4
Patch foraging water rate 24 sec0.20.31.4-0.7-0.70.3-0.7-1.0-0.31.20.30.30.2-0.3-0.2-0.10.4-0.1
Patch foraging water rate 6 sec0.20.31.1-0.60.00.00.0-1.1-0.21.00.2-0.1-0.10.2-0.20.51.0-0.6
Seeking ratio, delayed vs. immediate footshock0.60.82.00.61.2-1.21.20.30.6-0.4-0.7-1.1-0.50.50.61.41.1-0.9
Distance traveled before self-admin0.40.92.3-0.9-1.51.1-1.4-1.1-0.70.80.60.91.1-0.8-0.6-0.9-0.30.6
Distance traveled after self-admin0.10.20.6-0.50.1-0.20.2-0.8-0.30.70.30.0-0.00.1-0.30.40.7-0.5
Extensor digitorum longus weight0.10.30.60.70.3-0.30.30.80.6-0.6-0.6-0.3-0.50.60.6-0.1-0.5-0.3
Bone: elastic displacement1.01.31.81.31.2-1.11.21.41.2-1.2-1.2-1.2-1.21.41.20.7-0.1-0.7
Bone: elastic work0.40.51.10.51.0-0.91.00.10.5-0.2-0.5-0.8-0.70.80.41.00.7-0.8
Bone: endosteal estimation0.10.20.8-0.50.1-0.10.0-0.7-0.50.80.50.10.3-0.6-0.50.50.9-0.1
Bone: endosteal perimeter0.51.33.00.31.1-1.41.1-0.20.90.3-1.0-1.4-1.30.90.91.71.5-1.7
Epididymis fat weight1.15.69.0-2.1-3.02.8-2.8-1.5-2.21.92.32.72.3-2.9-2.2-2.6-1.22.3
Delta time in closed arm before/after self-admin0.80.84.4-1.1-0.2-0.40.2-1.2-0.70.80.6-0.30.5-0.6-0.61.42.1-0.2
Delta time in open arm before/after self-admin0.70.92.01.11.0-0.90.90.91.0-0.6-1.0-0.8-1.31.41.00.2-0.5-0.5
Diff in mean of infusions in LGA sessions0.91.64.4-1.2-1.01.2-1.1-1.4-1.30.71.41.21.9-2.1-1.4-0.60.30.9
Delay discount exponential model param0.10.20.6-0.2-0.80.5-0.4-0.1-0.30.30.30.40.3-0.4-0.3-0.5-0.30.3
Extinction: sum of active levers before priming1.62.54.1-1.8-1.71.5-1.2-1.8-1.91.61.91.61.8-2.0-1.9-0.70.51.0
Active lever presses in extinction session 61.21.22.5-1.1-0.40.6-0.4-1.2-1.41.21.41.01.5-1.6-1.5-0.10.70.8
Bone: final force0.20.40.90.90.7-0.70.70.70.7-0.5-0.6-0.5-0.60.40.60.1-0.5-0.5
Bone: final moment0.30.51.00.91.0-0.91.00.50.7-0.4-0.7-0.7-0.80.50.60.4-0.1-0.7
Food consumed during 24 hour testing period0.50.93.8-0.80.8-0.30.6-1.6-0.61.20.6-0.20.0-0.2-0.71.32.0-1.1
Glucose0.20.31.0-0.6-0.0-0.2-0.0-1.0-0.20.90.1-0.2-0.2-0.1-0.10.71.0-0.4
Heart weight0.81.33.5-1.6-0.40.4-0.3-1.8-1.31.91.20.50.9-1.0-1.30.61.70.2
Delay discount hyperbolic model param0.10.20.6-0.3-0.80.6-0.4-0.2-0.30.30.30.50.2-0.4-0.3-0.5-0.30.3
Intermittent access intake day 1-15 change0.10.42.1-0.50.4-0.40.6-0.7-0.30.20.3-0.30.4-0.1-0.41.01.5-0.8
Intermittent access intake escalation0.10.52.1-0.80.1-0.10.3-1.1-0.60.80.60.00.6-0.4-0.60.81.4-0.6
Intermittent access intake escalation 20.81.43.70.31.5-1.51.6-0.20.6-0.0-0.7-1.3-0.80.90.51.91.9-1.7
Intermitt. access day 1 inactive lever presses0.22.24.01.71.2-1.21.32.01.8-1.9-1.7-1.4-1.61.41.80.6-0.6-0.8
Intermitt. access day 15 inactive lever presses0.00.10.30.3-0.00.10.00.60.2-0.5-0.20.0-0.00.10.2-0.3-0.50.0
Intermitt. access escalation Index0.30.83.10.7-0.30.8-0.31.50.4-1.8-0.40.2-0.30.30.5-1.1-1.60.9
Intermittent access day 1 total infusions0.61.93.6-1.0-1.71.7-1.9-0.3-1.10.51.21.71.2-1.1-1.1-1.9-1.41.7
Intermittent access day 15 total infusions0.51.31.9-1.3-1.31.2-1.3-0.9-1.30.81.31.31.4-1.1-1.3-0.9-0.10.9
Intermittent access terminal intake (last 3 days)0.50.81.6-1.3-0.60.8-0.7-0.9-1.30.61.20.91.1-0.8-1.3-0.10.70.5
Intermittent access total infusions1.21.42.4-1.5-1.01.2-1.2-1.1-1.51.01.51.21.4-1.1-1.5-0.50.40.8
Intermittent access day 1 locomotion0.40.81.6-0.7-1.21.2-1.3-0.3-0.70.40.71.10.6-0.6-0.7-1.3-0.90.9
Intermittent access day 15 total locomotion0.20.72.0-1.1-0.60.6-0.7-1.3-1.01.40.90.70.7-0.5-0.9-0.20.6-0.1
Intermittent access total locomotion1.41.73.5-1.9-0.91.0-1.0-1.8-1.61.91.61.11.2-1.0-1.6-0.11.20.2
Intermittent access standard deviation0.00.10.3-0.10.1-0.10.10.2-0.3-0.00.30.20.6-0.4-0.40.00.10.2
Left kidney weight0.21.82.41.41.4-1.51.51.31.5-1.4-1.5-1.6-1.31.41.51.20.3-1.1
Right kidney weight0.21.63.31.61.0-0.91.01.81.5-1.8-1.5-1.2-1.31.21.50.3-0.8-0.5
Cocaine induced anxiety0.30.81.40.90.9-0.90.90.71.0-0.7-1.0-0.9-1.21.20.90.70.1-0.7
Post-drug Anxiety0.91.11.71.01.3-1.31.30.51.0-0.7-1.0-1.2-1.31.11.01.10.5-1.0
Baseline Anxiety0.00.00.1-0.10.0-0.1-0.0-0.3-0.10.20.10.10.1-0.2-0.20.00.10.0
Tail length0.00.00.10.00.10.10.1-0.1-0.1-0.30.10.10.4-0.0-0.1-0.1-0.0-0.3
Length with tail0.10.30.4-0.6-0.30.6-0.3-0.6-0.70.50.70.50.5-0.6-0.7-0.20.20.2
Length without tail0.21.22.0-1.1-1.11.1-1.0-0.8-1.21.01.21.21.1-1.4-1.2-0.8-0.11.2
Times rat made contact with spout1.01.12.6-0.5-1.11.4-1.10.1-0.8-0.10.91.20.9-1.2-0.8-1.5-1.21.6
Lifetime Intake1.01.22.1-1.4-1.01.0-1.1-1.1-1.41.01.41.11.3-1.1-1.3-0.50.40.8
Liver weight, left0.00.10.2-0.20.1-0.1-0.0-0.4-0.10.50.1-0.00.1-0.0-0.10.20.4-0.5
Liver weight, right1.93.45.21.52.3-2.22.20.91.7-1.1-1.8-2.1-1.91.91.72.11.2-2.2
Locomotor activity0.10.10.4-0.5-0.30.1-0.1-0.4-0.20.60.1-0.0-0.20.0-0.10.30.6-0.1
Locomotor testing distance0.10.31.5-0.7-0.0-0.20.0-0.9-0.31.20.2-0.1-0.20.0-0.20.71.2-0.6
Locomotor testing rearing0.00.10.30.20.4-0.30.40.10.10.0-0.1-0.2-0.50.20.10.30.2-0.5
Locomotion in novel chamber0.20.30.70.00.7-0.60.7-0.6-0.10.60.1-0.3-0.1-0.0-0.20.70.8-0.8
Locomotion in novel chamber post-restriction0.41.32.7-0.5-1.10.8-1.1-0.2-1.00.41.11.31.7-1.6-1.1-1.3-1.01.6
Fecal boli incidents, locomotor time 10.20.52.1-0.90.00.0-0.3-1.4-0.71.40.60.20.5-0.1-0.70.40.9-0.5
Change in fecal boli incidents, locomotor task0.00.00.2-0.2-0.40.2-0.2-0.1-0.20.10.20.10.0-0.3-0.2-0.00.10.4
Time >=10cm from walls, locomotor time 13.23.97.51.92.7-2.42.41.01.9-1.0-2.0-2.3-2.32.01.82.11.0-2.0
Bouts of movement, locomotor time 11.21.66.80.2-1.11.7-1.31.1-0.1-1.00.21.20.20.1-0.0-2.3-2.61.5
Total resting periods, locomotor time 11.31.56.30.1-1.11.6-1.31.0-0.2-0.80.31.20.20.0-0.1-2.3-2.51.4
Rest time, locomotor task time 10.91.52.7-1.3-1.51.4-1.6-0.9-1.21.21.21.40.9-0.9-1.1-1.3-0.51.3
Distance moved, locomotor task time 12.15.99.02.23.0-2.92.81.42.4-1.3-2.5-2.8-2.62.82.42.61.3-2.7
Vertical activity count, locomotor time 10.31.92.81.31.5-1.61.60.91.4-1.0-1.5-1.6-1.31.51.41.40.6-1.7
Time >=10cm from walls, locomotor time 20.30.83.00.51.7-1.01.10.60.5-0.2-0.5-1.0-0.70.90.41.31.0-0.9
Bouts of movement, locomotor time 20.20.51.70.6-0.10.2-0.11.30.6-1.2-0.6-0.0-0.60.70.7-0.7-1.30.2
Total resting periods, locomotor time 20.10.31.30.3-0.40.3-0.30.90.3-0.9-0.30.2-0.50.50.4-0.8-1.10.3
Rest time, locomotor task time 20.10.20.60.50.2-0.50.50.30.5-0.4-0.5-0.4-0.80.70.50.2-0.1-0.6
Distance moved, locomotor task time 20.30.41.10.71.1-0.40.60.90.7-0.6-0.7-0.7-0.71.00.60.50.0-0.4
Vertical activity count, locomotor time 20.20.41.30.80.4-0.30.31.10.8-0.9-0.8-0.6-0.50.70.80.2-0.4-0.2
Light reinforcement 10.21.12.3-0.9-1.51.1-1.5-0.5-0.80.80.81.11.0-1.2-0.8-1.1-0.61.1
Light reinforcement 20.10.20.30.40.4-0.50.40.40.5-0.5-0.5-0.6-0.50.50.50.50.2-0.2
Bone: marrow area0.10.20.8-0.50.1-0.20.1-0.7-0.40.80.4-0.00.2-0.5-0.50.60.9-0.2
Bone: maximum diameter4.08.111.72.13.2-3.43.21.22.8-1.2-2.9-3.4-3.43.12.83.32.0-3.3
Bone: maximum force0.71.42.21.31.5-1.51.50.71.2-0.7-1.2-1.3-1.40.91.21.10.3-1.1
Bone: maximum moment0.91.72.91.21.7-1.71.70.61.3-0.6-1.3-1.5-1.51.11.21.40.7-1.3
Mean time between licks in bursts0.00.31.20.5-0.20.4-0.20.70.1-0.9-0.00.30.3-0.40.1-0.8-1.10.6
Mean num. licks in bursts0.10.20.50.4-0.20.0-0.00.60.4-0.5-0.4-0.1-0.30.20.5-0.4-0.70.1
Cd content in liver1.11.22.0-1.2-1.41.3-1.4-1.0-1.11.01.11.21.1-0.9-1.0-1.0-0.30.9
Co content in liver1.11.32.5-1.5-1.20.8-1.1-1.5-1.21.61.20.91.3-1.3-1.2-0.20.80.5
Cu content in liver0.40.41.70.2-0.60.8-0.60.6-0.1-0.80.10.60.5-0.2-0.1-1.1-1.30.8
Fe content in liver0.30.40.9-0.4-0.50.8-0.6-0.1-0.6-0.00.60.71.0-0.8-0.6-0.6-0.40.8
K content in liver0.80.73.10.9-0.50.5-0.31.40.7-1.2-0.70.1-0.40.20.8-1.1-1.80.4
Mg content in liver0.91.04.60.6-0.91.0-0.81.20.2-1.1-0.10.70.3-0.40.2-1.7-2.11.0
Mn content in liver1.41.67.80.8-1.41.1-1.01.60.5-1.3-0.50.70.1-0.30.7-2.2-2.80.9
Na content in liver0.20.20.7-0.0-0.50.6-0.50.3-0.2-0.10.30.60.4-0.4-0.2-0.8-0.80.6
Rb content in liver1.31.52.6-1.2-1.61.3-1.6-1.1-1.21.21.21.41.4-1.4-1.1-1.2-0.51.0
Se content in liver2.22.611.01.1-1.01.4-0.92.50.4-2.2-0.21.00.4-0.20.4-2.5-3.31.9
Sr content in liver0.30.20.50.50.2-0.30.30.50.6-0.2-0.6-0.5-0.60.50.70.1-0.2-0.6
Zn content in liver0.91.01.8-0.7-1.01.3-1.2-0.0-1.00.21.01.21.1-0.7-1.0-1.2-0.81.3
Bone: minimum diameter0.81.52.70.81.4-1.51.40.31.1-0.2-1.1-1.4-1.41.31.11.51.0-1.6
Time in familiar zone, hab. session 10.10.10.5-0.4-0.50.1-0.4-0.5-0.00.7-0.00.00.1-0.20.00.10.30.1
Time in novel zone, hab. session 11.11.22.11.21.5-1.21.41.11.0-1.1-1.0-1.1-1.21.30.90.90.1-1.0
Total zone transitions, hab. session 10.50.73.0-0.80.2-0.40.2-1.4-0.21.50.0-0.5-0.60.4-0.11.11.7-1.0
Total locomotion distance, hab. session 10.91.32.30.70.9-1.41.10.51.2-0.2-1.3-1.4-1.31.51.31.30.9-1.1
Locomotion velocity, hab. session 10.30.50.90.20.4-0.80.50.10.70.2-0.8-0.9-0.80.90.80.90.8-0.6
Time in familiar zone, hab. session 20.40.50.80.70.6-0.90.80.50.8-0.9-0.9-0.9-0.70.40.80.70.2-0.2
Time in novel zone, hab. session 20.91.01.7-1.1-0.71.1-0.9-1.0-1.31.31.31.21.1-0.8-1.3-0.70.10.2
Total zone transitions, hab. session 20.10.10.50.50.10.00.00.40.4-0.1-0.4-0.0-0.40.40.4-0.4-0.7-0.3
Total locomotion distance, hab. session 21.21.52.81.50.8-1.10.91.51.6-1.2-1.6-1.2-1.41.41.70.3-0.6-0.7
Locomotion velocity, hab. session 21.01.32.61.40.7-1.10.91.41.5-1.0-1.5-1.2-1.41.31.60.4-0.4-0.5
Novel to familiar place preference ratio0.30.42.30.7-0.30.4-0.21.10.3-0.8-0.30.30.2-0.10.3-1.0-1.50.4
Novelty place preference0.40.52.50.9-0.20.3-0.21.30.4-1.0-0.40.20.1-0.10.4-1.0-1.60.4
Time in novel zone, NPP test0.30.42.10.8-0.10.2-0.11.20.5-0.8-0.40.10.0-0.00.5-0.9-1.40.2
Total zone transitions, NPP test0.60.92.3-1.3-0.50.7-0.6-1.5-1.21.41.20.80.8-0.9-1.2-0.00.80.1
Total locomotion distance, NPP test0.30.50.70.80.7-0.80.70.70.8-0.7-0.8-0.8-0.60.70.80.5-0.0-0.4
Locomotion velocity, NPP test0.40.60.91.00.7-0.90.80.81.0-0.9-1.0-0.9-0.80.90.90.5-0.1-0.3
Intraocular pressure0.81.42.9-1.5-0.80.8-0.9-1.7-1.51.71.51.11.1-1.1-1.5-0.30.70.5
Delta distance traveled before/after self-admin1.61.83.70.81.8-1.91.80.40.9-0.1-0.9-1.4-1.61.40.81.81.3-1.5
Delta ambulatory time before/after self-admin0.61.02.41.01.5-1.51.40.90.8-0.4-0.7-1.0-1.10.90.71.00.4-1.0
Parametrial fat weight0.92.03.91.70.8-1.21.01.71.9-1.5-1.9-1.5-1.61.42.00.5-0.6-0.9
Pavlov. Cond. lever latency0.91.12.70.1-0.81.3-0.81.2-0.4-1.30.51.00.8-0.7-0.5-1.5-1.61.6
Pavlov. Cond. magazine entry latency1.41.84.20.91.8-2.01.8-0.00.9-0.1-1.0-1.6-0.90.80.82.01.5-1.5
Pavlov. Cond. change in total contacts0.60.61.60.30.9-1.30.9-0.40.50.6-0.5-0.8-0.70.70.51.10.9-1.1
Pavlov. Cond. index score1.11.43.30.31.3-1.71.3-0.80.60.7-0.7-1.3-0.80.70.61.81.7-1.6
Pavlov. Cond. latency score0.81.02.40.10.9-1.41.0-0.90.50.9-0.5-1.0-0.70.60.51.51.5-1.4
Pavlov. Cond. lever contacts1.11.32.90.51.2-1.61.2-0.60.80.6-0.9-1.3-1.11.00.81.61.3-1.7
Pavlov. Cond. magazine entry number1.01.33.1-0.8-1.51.7-1.50.1-0.8-0.20.81.30.8-0.6-0.7-1.6-1.31.4
Pavlov. Cond. intertrial magazine entries0.50.62.50.90.10.6-0.01.20.5-1.6-0.50.1-0.30.30.5-0.9-1.60.0
Pavlov. Cond. lever-magazine prob. diff.1.31.63.90.51.5-1.91.5-0.60.80.5-0.9-1.5-1.00.80.72.01.7-1.7
Pavlov. Cond. response bias2.22.85.71.12.0-2.42.1-0.21.30.1-1.4-2.0-1.51.31.32.31.8-2.1
Pavlov. Cond. lever latency0.60.91.80.61.1-1.21.10.20.8-0.1-0.9-1.1-0.91.00.81.20.8-1.4
Pavlov. Cond. magazine entry latency0.00.00.10.10.3-0.20.20.0-0.00.10.1-0.0-0.00.0-0.10.0-0.0-0.1
Pavlov. Cond. change in total contacts0.30.71.2-0.6-1.10.8-1.1-0.4-0.70.50.70.90.8-0.8-0.7-1.0-0.71.1
Pavlov. Cond. index score0.30.50.7-0.6-0.70.7-0.7-0.5-0.70.50.70.80.7-0.8-0.7-0.7-0.30.9
Pavlov. Cond. latency score0.20.30.5-0.6-0.60.5-0.6-0.5-0.60.60.60.60.5-0.7-0.6-0.4-0.00.7
Pavlov. Cond. lever contacts0.81.12.2-0.8-1.21.3-1.3-0.2-1.00.21.01.31.1-1.1-1.0-1.3-0.91.5
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.10.2-0.1-0.3-0.20.30.20.00.10.0-0.10.10.4-0.3
Pavlov. Cond. intertrial magazine entries0.30.72.20.51.5-1.01.30.20.3-0.5-0.3-0.8-0.40.40.11.21.0-0.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.6-0.60.6-0.7-0.5-0.70.50.70.80.6-0.8-0.7-0.6-0.20.8
Pavlov. Cond. response bias0.70.91.5-0.6-1.01.2-1.1-0.2-0.90.20.91.21.0-1.1-0.9-1.2-0.91.2
Time in closed arm before self-admin0.50.91.61.21.2-0.90.90.61.1-0.7-1.1-0.9-1.11.11.10.5-0.3-1.0
Time in closed arm after self-admin1.01.22.70.71.0-1.41.40.10.9-0.5-0.9-1.4-1.00.70.91.61.2-1.5
Time in open arm before self-admin0.20.20.7-0.4-0.3-0.2-0.4-0.4-0.20.40.2-0.00.8-0.9-0.20.40.60.4
Time in open arm after self-admin0.30.30.80.10.9-0.80.7-0.10.30.2-0.3-0.5-0.50.60.20.70.7-0.2
Bone: periosteal estimation0.40.91.60.71.2-1.31.10.30.8-0.1-0.8-1.1-1.00.90.81.20.8-1.2
Bone: periosteal perimeter1.42.74.41.42.0-2.12.00.71.6-0.6-1.6-1.9-1.81.61.51.91.1-2.0
Bone: post-yield work0.71.14.0-0.11.1-1.41.1-0.70.40.7-0.5-1.2-0.90.50.41.92.0-1.1
Progressive ratio test 1 active lever presses0.61.12.4-1.1-1.41.2-1.6-0.5-1.00.91.01.21.0-1.0-0.9-1.1-0.51.1
Progressive ratio test 1 breakpoint0.61.02.4-0.9-1.41.1-1.5-0.5-0.90.80.91.11.0-0.9-0.8-1.2-0.61.0
Progressive ratio test 1 inactive lever presses0.20.51.90.2-0.80.7-0.80.60.0-0.30.00.60.5-0.50.1-1.1-1.40.8
Progressive ratio test 2 active lever presses1.52.23.3-1.8-1.51.4-1.6-1.6-1.71.61.71.51.6-1.6-1.7-0.80.30.8
Progressive ratio test 2 breakpoint1.72.23.4-1.9-1.41.3-1.6-1.7-1.81.71.71.51.6-1.6-1.7-0.70.50.8
Progressive ratio test 2 inactive lever presses0.51.52.9-1.1-1.51.7-1.5-0.2-1.20.31.21.51.4-1.2-1.1-1.4-0.81.3
Incentive Sensitization - Responses0.61.74.4-1.7-0.70.7-0.7-2.1-1.61.81.50.91.2-1.3-1.60.21.4-0.0
Incentive Sensitization - Breakpoint0.81.95.0-1.9-0.70.7-0.7-2.2-1.71.91.60.91.3-1.3-1.70.41.6-0.1
Sum of active levers in priming session hrs 5-61.81.72.7-1.6-1.11.2-1.1-1.6-1.51.51.51.11.5-1.7-1.5-0.30.80.6
Progressive ratio0.00.10.5-0.20.0-0.2-0.0-0.4-0.30.70.30.10.4-0.3-0.30.10.30.3
Food seeking constrained by brief footshock1.92.34.8-2.1-1.21.0-1.2-2.2-1.72.11.71.11.4-1.7-1.70.11.50.9
Seeking ratio, punishment vs. effort0.20.40.8-0.9-0.70.7-0.7-0.9-0.70.60.70.60.4-0.6-0.6-0.20.40.2
Retroperitoneal fat weight0.31.26.01.1-0.90.6-0.61.60.9-1.0-0.80.3-0.40.11.0-1.7-2.50.6
Reaction time number correct0.00.10.6-0.10.00.0-0.0-0.20.20.1-0.2-0.1-0.80.60.20.00.1-0.3
Reaction time mean minus median0.74.46.52.51.9-2.02.02.22.6-2.1-2.5-2.2-2.32.32.51.2-0.4-1.8
Reaction time mean minus median AUC0.85.17.92.71.9-2.02.02.32.8-2.3-2.8-2.4-2.52.52.81.2-0.5-1.9
Reaction time num false alarms0.00.10.40.40.6-0.50.40.30.1-0.1-0.0-0.1-0.20.1-0.00.2-0.1-0.0
Reaction time num false alarms AUC0.00.10.3-0.10.5-0.30.3-0.2-0.40.40.40.10.1-0.1-0.40.30.40.0
Reaction time trials correct on left0.00.10.6-0.10.00.0-0.0-0.20.20.1-0.2-0.1-0.80.60.20.00.1-0.3
Reaction time trials on left0.00.10.7-0.00.00.1-0.0-0.10.3-0.0-0.3-0.1-0.80.60.3-0.0-0.1-0.3
Reaction time mean1.63.66.02.41.9-1.91.92.32.2-2.5-2.1-1.9-1.61.82.11.0-0.5-1.1
Reaction time mean AUC1.94.77.52.72.2-2.12.22.62.5-2.7-2.5-2.2-1.92.02.41.2-0.5-1.3
Median of all reaction times1.72.74.82.11.8-1.71.82.01.8-2.2-1.8-1.7-1.31.51.71.0-0.3-0.9
Reaction time omissions1.82.97.92.31.0-0.70.92.81.9-2.7-1.8-1.0-1.51.41.8-0.5-2.10.5
Reaction time false alarm rate0.10.10.3-0.10.3-0.20.1-0.1-0.40.30.50.20.5-0.4-0.50.10.20.2
Reaction time premature initiation rate0.30.52.70.70.00.10.11.30.5-1.6-0.5-0.1-0.30.50.5-0.4-0.90.3
Reaction time premature initiations0.20.52.30.60.2-0.00.21.10.6-1.5-0.6-0.3-0.70.90.7-0.2-0.70.0
Std. dev. reaction times1.75.89.03.02.3-2.32.42.82.8-2.7-2.8-2.4-2.42.42.81.2-0.7-1.6
Reaction time trials completed0.00.10.7-0.00.00.1-0.0-0.10.3-0.0-0.3-0.1-0.80.60.3-0.0-0.1-0.3
Reaction time trials AUC0.00.10.3-0.3-0.20.3-0.3-0.3-0.00.2-0.00.1-0.60.30.1-0.2-0.1-0.1
Run reversals in cocaine runway, females0.10.10.3-0.1-0.50.5-0.40.40.1-0.1-0.10.1-0.30.50.2-0.5-0.50.1
Run reversals in cocaine runway, males0.00.00.20.40.2-0.30.10.20.10.0-0.10.00.2-0.10.1-0.2-0.4-0.0
Latency to leave start box in cocaine runway0.30.42.1-0.70.4-0.20.4-0.9-0.50.40.4-0.20.1-0.1-0.61.01.5-0.6
Latency to leave start box in cocaine runway, F0.10.10.5-0.10.3-0.30.3-0.40.10.0-0.1-0.3-0.40.30.00.60.7-0.7
Latency to leave start box in cocaine runway, M0.50.52.6-0.70.6-0.40.5-0.7-0.60.50.5-0.20.2-0.1-0.61.11.6-0.4
Std. dev. time between licks in bursts0.40.72.61.0-0.30.2-0.21.40.7-1.5-0.60.0-0.0-0.00.7-0.9-1.60.6
Total sessions with >9 infusions0.70.91.3-0.9-1.11.0-1.1-0.9-1.00.71.01.01.1-1.1-0.9-0.8-0.30.8
Short access day 1 total inactive lever presses0.30.51.0-1.0-0.30.4-0.3-1.0-0.91.00.90.50.6-0.7-0.90.20.80.3
Short access day 10 total inactive lever presses0.21.12.91.40.4-0.40.61.71.3-1.6-1.2-0.6-1.00.61.3-0.4-1.4-0.2
Short access day 1 total infusions0.30.61.3-0.4-0.90.9-1.0-0.0-0.5-0.20.60.90.7-0.8-0.5-1.1-1.01.1
Short access day 10 total infusions1.01.72.7-1.6-1.11.4-1.3-1.2-1.61.01.61.51.3-1.2-1.6-0.90.11.2
Short access total infusions0.40.60.9-0.9-0.80.7-0.9-0.7-0.90.50.90.80.9-0.9-0.8-0.50.00.8
Short access day 1 locomotion0.40.63.60.7-0.50.5-0.50.90.3-0.8-0.20.50.2-0.30.3-1.4-1.90.7
Short access day 10 total locomotion0.31.12.1-1.0-1.41.2-1.4-0.8-0.90.70.91.21.0-1.1-0.9-1.1-0.50.9
Short access total locomotion0.71.01.7-1.1-1.31.1-1.3-1.1-1.01.00.91.11.1-1.1-0.9-0.9-0.20.7
One hour access (0.3 mA shock)0.91.11.8-1.3-1.21.0-1.1-0.7-1.20.91.21.11.3-1.3-1.2-0.60.20.7
Compulsive drug intake0.10.10.30.1-0.4-0.0-0.3-0.50.30.6-0.4-0.2-0.1-0.00.4-0.0-0.1-0.4
One hour access (shock baseline)0.41.12.1-1.3-0.70.8-0.7-0.7-1.40.81.41.01.4-1.3-1.5-0.20.60.7
Social response proportion0.10.20.60.2-0.20.4-0.10.50.0-0.70.00.30.2-0.20.0-0.6-0.80.6
Social responses0.70.93.91.0-0.30.4-0.11.50.8-2.0-0.7-0.1-0.2-0.10.8-0.9-1.70.7
Social time0.20.41.40.4-0.40.4-0.31.00.4-1.0-0.40.1-0.30.30.4-0.8-1.20.6
Soleus weight7.622.545.5-6.6-3.73.7-3.9-6.7-5.76.55.53.94.2-4.3-5.6-0.53.92.0
Bone: stiffness1.42.63.51.81.7-1.91.81.31.9-1.2-1.9-1.8-1.81.51.81.20.1-1.5
Tibialis anterior weight1.65.67.6-2.8-2.52.6-2.5-2.2-2.72.22.72.62.5-2.6-2.7-1.60.12.0
Time to tail flick, vehicle, before self-admin0.30.42.0-0.6-0.0-0.2-0.0-0.9-0.00.8-0.1-0.5-0.10.10.01.01.4-0.6
Time to tail flick, vehicle, after self-admin0.20.51.7-0.30.5-0.70.3-0.80.20.9-0.3-0.7-0.50.40.31.11.3-1.1
Time to tail flick, test, before self-admin1.11.22.4-1.3-1.51.1-1.3-1.2-1.00.91.01.01.3-1.4-1.0-0.70.10.9
Time to tail flick, test, after self-admin1.92.03.9-1.9-1.31.5-1.2-1.6-1.61.11.51.01.7-2.0-1.50.01.31.1
Delta time to tail flick, vehicle, before/after SA0.20.20.90.2-0.20.5-0.40.4-0.0-0.40.10.40.3-0.2-0.0-0.9-1.00.4
Delta time to tail flick, test, before/after SA0.10.10.3-0.30.00.5-0.1-0.0-0.3-0.10.30.20.3-0.4-0.4-0.10.20.3
Tibia length0.10.20.30.10.5-0.50.5-0.10.20.1-0.2-0.4-0.50.30.20.60.5-0.6
Ambulatory time before self-admin0.20.72.1-0.4-1.51.0-1.2-0.3-0.30.40.40.80.9-0.6-0.3-1.1-0.90.7
Ambulatory time after self-admin0.10.10.4-0.00.4-0.50.4-0.3-0.00.60.0-0.2-0.30.4-0.00.30.4-0.6
Bone: tissue strength0.60.72.2-0.60.5-0.50.4-1.5-0.71.40.60.00.3-0.5-0.80.81.3-0.6
Total heroin consumption0.81.02.0-1.1-1.00.9-1.0-1.1-1.10.81.10.91.3-1.4-1.1-0.40.30.7
Bone: trabecular number0.10.30.6-0.7-0.70.7-0.7-0.5-0.40.70.40.50.2-0.7-0.3-0.40.00.3
Bone: trabecular spacing0.10.10.4-0.4-0.20.0-0.2-0.6-0.40.60.40.30.60.0-0.40.00.3-0.2
Bone: trabecular thickness0.20.30.5-0.5-0.40.7-0.5-0.2-0.60.30.70.70.6-0.7-0.6-0.6-0.30.5
Bone: trabecular tissue density0.30.53.00.8-0.40.3-0.31.00.4-0.9-0.30.30.10.10.4-1.2-1.70.5
Water consumed over 24 hours0.20.30.9-0.4-0.50.7-0.5-0.5-0.60.40.60.70.7-0.9-0.6-0.6-0.30.4
Number of responses in last shaping day1.62.13.2-1.8-1.81.3-1.7-1.6-1.41.61.41.31.5-1.6-1.3-0.80.31.1