Hub : Genes

Hexim2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg isoform ratio XM_006247520.5 0.28 0.15 8.5e-03 0.01 0.02 0.05 0.04 2.0e-01 1.0e-01 2.1e-02 2.6e-02
2 PL mRNA stability Hexim2 0.03 0.02 6.5e-03 0.02 0.01 0.01 0.01 5.6e-03 1.5e-02 7.7e-03 4.4e-02
3 NAcc alternative TSS NM_001107054.2 0.03 0.02 3.9e-04 0.02 0.02 0.02 0 1.8e-04 4.3e-04 7.4e-04 2.9e-01
4 IL alternative TSS XM_063269173.1 0.2 0.1 5.0e-04 0.11 0.02 0.07 -0.01 1.6e-03 9.2e-02 9.8e-03 4.9e-01
5 NAcc alternative TSS XM_063269173.1 0.02 0.02 4.5e-03 0.01 0.02 0.01 0.01 2.7e-02 1.4e-03 3.8e-03 1.7e-02
6 Liver gene expression Hexim2 0.06 0.03 4.9e-07 0.06 0.05 0.06 0.05 4.8e-07 7.2e-06 8.7e-07 1.8e-06
7 pVTA mRNA stability Hexim2 0.03 0.02 9.3e-03 0.04 0.02 0.03 0.03 6.3e-04 7.0e-03 4.1e-03 3.7e-03
8 NAcc isoform ratio XM_006247516.5 0.02 0.02 8.4e-03 0 0.01 0 0 1.2e-01 2.4e-02 1.4e-01 5.9e-02
9 Liver alternative TSS XM_006247515.5 0.04 0.02 1.1e-03 -0 0.01 -0 0 4.6e-01 5.3e-02 6.0e-01 3.2e-01
10 RMTg isoform ratio XM_006247518.5 0.3 0.14 5.1e-03 -0.01 -0 -0.01 -0 9.6e-01 4.7e-01 5.9e-01 3.9e-01
11 NAcc gene expression Hexim2 0.03 0.02 2.3e-04 0.03 0.03 0.03 0.03 6.0e-05 5.2e-05 9.9e-05 6.8e-05
12 pVTA gene expression Hexim2 0.06 0.04 1.6e-03 0.02 0.03 0.03 0.03 1.1e-02 1.2e-03 2.3e-03 3.8e-03
13 PL gene expression Hexim2 0.11 0.07 1.0e-05 0.02 0.04 0.03 0.03 1.3e-03 1.7e-05 9.4e-04 2.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.35.00.2-1.6-1.91.8-0.90.2-1.8-1.2-0.51.12.22.11.8
Area under the delay curve0.10.10.5-0.7-0.00.1-0.3-0.20.20.1-0.10.3-0.2-0.5-0.4-0.4
BMI with tail0.72.57.30.30.31.0-0.8-0.72.20.7-0.42.71.8-2.6-2.0-1.9
BMI without tail0.63.110.1-0.5-1.3-0.60.6-2.03.2-0.7-1.72.92.4-1.6-1.1-1.3
Body weight1.98.526.10.1-1.8-1.92.0-3.44.6-1.5-3.24.25.1-2.1-1.8-1.9
Weight adjusted by age0.20.51.5-0.8-0.40.10.5-0.70.7-0.2-0.60.70.6-0.9-1.2-0.9
Bone surface2.95.812.6-1.6-3.1-2.93.5-2.61.7-3.4-2.80.92.01.91.71.3
Bone volume1.93.87.6-1.0-2.7-2.42.7-1.81.1-2.7-2.00.41.42.01.91.7
Breakpoint value in progressive ratio session0.50.95.1-2.3-0.6-1.00.9-0.80.3-1.1-0.80.1-1.00.30.1-0.3
Number of licking bursts0.41.44.2-0.01.1-0.30.1-0.91.30.0-0.91.41.5-1.4-1.7-2.0
Context. condit. distance diff. score1.21.42.91.61.41.5-1.50.8-0.21.71.10.10.3-1.5-1.3-0.8
Locomotion velocity, session 10.40.41.40.4-0.80.40.20.4-0.7-0.40.4-0.7-0.30.70.91.2
Locomotion distance, session 10.30.41.20.5-0.40.7-0.20.6-1.00.20.7-0.5-0.70.40.71.1
Locomotion velocity, session 21.41.64.51.2-0.20.6-0.51.2-2.10.11.2-1.9-1.31.31.31.9
Locomotion distance, session 20.50.72.30.6-0.40.60.10.7-1.5-0.00.7-0.9-1.10.81.01.4
Locomotion velocity, session 30.20.20.91.0-0.10.10.40.2-0.00.20.2-0.30.60.40.40.6
Locomotion distance, session 30.20.20.50.30.50.00.4-0.30.30.3-0.20.30.7-0.5-0.7-0.6
Stereotopy head waving bouts, day 31.11.32.20.70.41.3-1.21.5-1.20.81.5-1.3-1.10.81.11.3
Stereotopy head waving duration, day 30.81.02.10.20.81.2-1.31.3-0.90.91.4-1.0-1.50.30.60.8
Locomotion velocity, session 70.80.92.81.71.00.8-0.71.2-0.71.41.2-0.9-0.10.10.20.4
Locomotion distance, session 70.50.61.91.40.90.8-0.60.8-0.81.11.0-0.6-0.2-0.3-0.30.2
Stereotopy head waving bouts, day 70.40.41.60.00.6-0.60.60.4-0.7-0.5-0.0-1.1-0.41.30.80.4
Stereotopy head waving duration, day 70.70.82.20.21.3-0.0-0.01.0-1.30.10.7-1.5-1.21.20.80.4
Locomotion velocity, session 80.40.52.61.1-0.01.6-0.70.60.20.50.70.40.4-0.60.00.4
Locomotion distance, session 80.91.33.01.50.81.7-1.11.4-1.41.41.5-0.9-1.0-0.4-0.10.6
Degree of sensitization distance0.10.10.50.7-0.10.3-0.60.10.00.20.20.20.4-0.5-0.30.2
Degree of sensitization stereotypy0.30.30.80.30.8-0.70.60.3-0.7-0.4-0.1-0.9-0.10.90.2-0.1
Conditioned locomotion0.10.10.40.60.3-0.3-0.0-0.00.10.1-0.0-0.20.40.20.10.1
Cocaine response after cond. corrected0.30.53.21.5-0.2-0.80.2-0.30.2-0.0-0.40.01.80.30.10.3
Cocaine response after cond. not corrected0.81.14.12.0-0.6-1.40.8-0.4-0.2-0.4-0.6-0.62.01.20.80.9
Cocaine response before conditioning0.40.51.70.4-0.7-0.40.80.1-0.7-0.6-0.1-0.9-0.31.31.11.0
Saline control response0.40.51.3-1.1-0.7-0.60.9-0.90.9-0.8-0.90.90.1-0.10.1-0.4
Bone: connectivity density1.93.06.1-0.5-2.0-2.32.3-1.40.2-2.5-1.7-0.31.12.21.91.6
Bone: cortical apparent density4.36.814.91.52.42.1-2.23.4-3.92.43.2-3.3-3.51.41.51.6
Bone: cortical area1.32.24.0-1.1-2.0-1.72.0-1.10.8-1.9-1.30.20.81.71.81.5
Bone: cortical porosity8.69.418.4-2.2-4.3-3.64.0-3.83.0-3.9-3.82.13.01.21.00.8
Bone: cortical porosity6.26.813.0-1.3-3.6-2.83.2-3.32.9-3.1-3.22.33.30.60.60.5
Bone: cortical thickness1.32.14.81.90.8-0.3-0.11.4-1.70.41.0-2.10.02.22.12.0
Bone: cortical thickness1.62.05.61.30.4-1.00.90.8-1.7-0.40.4-2.4-0.02.31.91.9
Bone: cortical tissue density4.26.714.71.32.32.0-2.23.4-3.82.33.1-3.2-3.61.41.51.5
Condit. Reinf. active minus inactive responses1.01.12.9-1.7-1.2-1.41.3-1.40.6-1.2-1.30.80.1-0.1-0.3-0.4
Condit. Reinf. active-inactive response ratio0.30.31.0-1.0-0.2-0.50.6-0.70.1-0.4-0.60.3-0.2-0.5-0.8-0.6
Condit. Reinf. active responses0.70.92.2-1.5-1.5-1.31.2-1.10.4-1.1-1.00.4-0.30.40.50.3
Condit. Reinf. inactive responses0.60.83.2-0.0-1.0-0.50.50.1-0.2-0.60.0-0.4-0.31.41.81.6
Incentive salience index mean0.91.22.7-1.6-1.4-1.51.5-1.30.5-1.3-1.30.5-0.10.40.2-0.1
Condit. Reinf. lever presses0.30.41.1-0.5-1.0-0.80.9-0.3-0.3-0.5-0.4-0.2-0.41.01.00.6
Condit. Reinf. active minus inactive responses2.13.27.1-1.2-2.7-2.42.5-1.80.4-2.6-1.9-0.00.81.71.41.5
Condit. Reinf. active-inactive response ratio1.72.76.0-1.6-2.3-2.32.2-2.00.8-2.4-2.00.50.81.00.60.5
Condit. Reinf. active responses2.53.68.4-1.6-2.9-2.52.6-1.80.3-2.7-1.8-0.20.31.81.61.7
Condit. Reinf. inactive responses0.71.13.0-0.4-1.2-0.50.80.2-0.9-0.60.2-1.0-1.21.51.71.7
Condit. Reinf. lever presses0.91.32.8-1.5-1.7-1.51.3-0.8-0.1-1.3-0.8-0.4-0.71.21.21.2
Condit. Reinf. lever reinforcers received2.23.07.0-1.5-2.6-2.32.4-1.50.1-2.4-1.5-0.30.11.81.61.7
Conditioned reinforcement - actives0.10.41.8-1.3-0.0-0.80.4-0.60.5-0.2-0.60.6-0.5-0.3-0.2-0.6
Conditioned reinforcement - inactives0.51.32.3-0.7-1.0-1.51.2-1.41.3-1.4-1.51.11.40.50.60.1
Conditioned locomotion1.21.83.4-1.6-1.1-1.51.2-1.81.6-0.9-1.71.61.2-0.8-0.8-1.0
Patch foraging indifference point 0 sec0.71.96.70.4-1.4-1.11.20.0-0.4-0.7-0.1-1.2-0.22.22.62.6
Patch foraging indifference point AUC0.30.82.10.1-0.1-1.20.6-1.20.7-0.6-1.21.01.4-0.5-0.7-0.7
Delay disc. indifference point, 0s delay0.20.20.9-0.50.20.3-0.40.3-0.60.40.4-0.4-0.9-0.2-0.20.0
Delay disc. indifference point, 16s delay0.40.51.6-0.40.20.2-0.5-0.40.80.3-0.21.00.5-1.3-1.2-1.1
Delay disc. indifference point, 2s delay0.60.72.6-0.9-1.6-0.70.9-0.6-0.0-1.1-0.6-0.2-0.20.90.91.0
Delay disc. indifference point, 24s delay0.20.30.6-0.1-0.3-0.40.3-0.70.5-0.4-0.60.60.8-0.5-0.7-0.5
Delay disc. indifference point, 4s delay0.10.10.7-0.80.10.1-0.40.1-0.10.20.2-0.1-0.6-0.4-0.3-0.2
Delay disc. indifference point, 8s delay0.10.20.5-0.20.20.4-0.50.5-0.50.20.5-0.5-0.70.30.30.2
Indifference point function ln k0.30.82.0-0.7-1.4-0.51.1-0.20.2-1.0-0.3-0.6-0.21.41.31.2
Indifference point function log k0.30.82.0-0.7-1.4-0.51.1-0.20.2-1.0-0.3-0.6-0.21.41.31.2
Patch foraging total patch changes 0 sec0.72.16.90.2-1.7-1.21.3-0.1-0.2-1.0-0.2-0.9-0.12.22.62.6
Patch foraging total patch changes 12 sec1.01.34.0-0.0-1.2-1.21.0-0.2-0.7-0.8-0.3-0.7-0.41.72.02.0
Patch foraging total patch changes 18 sec0.10.30.70.0-0.5-0.80.8-0.60.2-0.5-0.60.10.40.40.40.6
Patch foraging total patch changes 24 sec0.41.54.80.1-1.2-1.11.3-0.2-0.2-1.0-0.3-0.8-0.02.02.22.1
Patch foraging total patch changes 6 sec0.40.72.20.3-0.8-1.51.1-0.5-0.4-0.6-0.6-0.30.51.11.21.2
Patch foraging time to switch 0 sec0.10.30.70.60.40.5-0.80.5-0.70.80.6-0.3-0.5-0.4-0.30.1
Patch foraging water rate 0 sec0.00.20.40.0-0.6-0.00.7-0.10.5-0.4-0.20.20.50.30.40.4
Patch foraging water rate 12 sec0.00.21.10.70.40.20.10.20.20.00.1-0.31.0-0.1-0.4-0.2
Patch foraging water rate 18 sec0.81.94.42.10.00.6-0.21.3-1.20.11.0-1.80.11.91.92.1
Patch foraging water rate 24 sec0.91.32.40.80.41.1-0.91.5-1.40.91.5-1.6-1.30.80.91.3
Patch foraging water rate 6 sec0.50.71.9-0.1-1.4-0.71.4-0.60.6-1.2-0.7-0.20.71.00.80.7
Seeking ratio, delayed vs. immediate footshock1.31.95.0-0.6-0.2-0.3-0.2-1.41.80.2-1.02.21.3-2.2-2.0-1.7
Distance traveled before self-admin0.20.42.1-1.5-0.5-0.50.3-0.2-0.2-0.5-0.1-0.3-1.10.30.30.4
Distance traveled after self-admin0.10.21.2-0.60.20.4-0.60.3-0.40.40.5-0.0-1.1-0.5-0.20.1
Extensor digitorum longus weight2.610.229.00.43.63.2-3.20.71.53.61.42.30.4-5.4-5.1-4.5
Bone: elastic displacement0.40.51.60.5-0.1-1.30.8-0.4-0.0-0.7-0.7-0.41.01.00.50.3
Bone: elastic work1.41.95.6-0.2-1.5-2.42.0-1.20.4-1.5-1.5-0.01.41.51.30.9
Bone: endosteal estimation3.17.516.3-4.0-4.0-2.02.9-3.63.2-2.9-3.13.11.2-0.9-0.6-0.6
Bone: endosteal perimeter4.912.122.5-4.7-4.3-2.73.4-4.54.5-3.9-4.24.12.2-1.0-0.8-1.2
Epididymis fat weight0.10.41.20.2-0.30.40.3-0.50.70.0-0.41.11.0-0.8-0.8-0.7
Delta time in closed arm before/after self-admin1.81.64.81.71.11.4-2.21.7-0.62.11.7-0.2-0.0-0.40.20.0
Delta time in open arm before/after self-admin1.11.410.8-3.3-0.0-0.40.6-0.50.2-0.5-0.40.4-2.1-0.4-0.4-0.8
Diff in mean of infusions in LGA sessions0.20.31.5-1.2-0.5-0.60.6-0.50.1-0.8-0.50.1-0.50.30.20.0
Delay discount exponential model param0.10.10.60.80.10.00.20.3-0.40.00.2-0.5-0.00.50.50.4
Extinction: sum of active levers before priming0.10.10.8-0.90.1-0.3-0.2-0.10.10.1-0.00.1-0.6-0.00.3-0.1
Active lever presses in extinction session 63.53.57.8-2.8-1.4-2.12.0-2.52.1-2.1-2.42.00.9-0.4-0.5-1.1
Bone: final force1.11.95.70.1-1.2-1.21.7-0.1-0.5-1.1-0.3-0.90.32.22.42.3
Bone: final moment1.42.36.90.2-1.3-1.31.7-0.0-0.6-1.2-0.3-1.10.32.52.62.6
Food consumed during 24 hour testing period0.30.71.6-0.4-0.6-0.40.6-0.91.3-0.6-0.91.21.2-0.6-0.6-1.0
Glucose0.91.43.51.11.41.9-1.71.3-0.71.51.4-0.2-0.5-1.1-0.9-0.5
Heart weight2.43.914.80.20.3-0.60.7-1.83.6-0.5-1.72.53.8-1.5-1.7-2.1
Delay discount hyperbolic model param0.10.20.91.00.30.10.00.4-0.30.20.3-0.40.10.40.30.3
Intermittent access intake day 1-15 change0.20.93.40.60.11.9-1.50.90.01.31.10.5-0.3-1.1-0.6-0.3
Intermittent access intake escalation0.20.83.20.5-0.31.8-1.40.9-0.11.31.20.4-0.4-0.9-0.30.1
Intermittent access intake escalation 20.30.51.90.2-0.51.4-0.90.40.50.90.70.80.1-0.8-0.2-0.0
Intermitt. access day 1 inactive lever presses0.45.314.8-3.9-2.3-2.52.6-2.62.8-2.6-2.72.40.90.20.2-0.9
Intermitt. access day 15 inactive lever presses0.73.714.9-3.9-2.5-2.02.4-1.90.7-2.6-1.90.7-0.41.10.80.5
Intermitt. access escalation Index0.20.82.0-1.40.60.8-0.1-0.10.70.2-0.00.8-0.7-1.2-1.3-1.4
Intermittent access day 1 total infusions0.41.14.3-2.10.0-1.20.6-1.11.0-0.5-1.01.0-0.3-0.8-0.8-1.2
Intermittent access day 15 total infusions0.41.03.9-2.0-0.80.1-0.5-0.51.10.4-0.11.5-0.8-1.6-1.0-0.9
Intermittent access terminal intake (last 3 days)1.01.77.8-2.8-1.1-0.60.4-1.31.5-0.4-0.91.7-0.8-1.4-1.0-1.1
Intermittent access total infusions1.61.95.3-2.3-0.6-0.80.4-1.41.7-0.3-1.12.0-0.1-1.7-1.4-1.6
Intermittent access day 1 locomotion1.01.83.5-1.7-1.1-1.91.0-1.81.6-1.0-1.71.70.8-0.8-0.6-0.8
Intermittent access day 15 total locomotion0.10.41.4-0.3-0.7-0.3-0.4-0.60.60.4-0.31.20.7-1.2-0.6-0.3
Intermittent access total locomotion1.51.83.4-1.3-1.7-1.50.8-1.81.6-0.9-1.61.91.2-1.1-0.7-0.6
Intermittent access standard deviation0.00.20.8-0.9-0.6-0.1-0.1-0.10.40.1-0.00.6-0.60.00.4-0.0
Left kidney weight0.10.95.42.3-0.0-0.20.4-0.20.70.1-0.30.22.20.1-0.10.2
Right kidney weight0.31.99.91.7-0.1-0.90.7-1.22.0-0.4-1.21.23.1-0.6-0.9-0.8
Cocaine induced anxiety0.30.75.52.30.60.8-0.40.8-0.40.30.5-0.51.20.60.40.3
Post-drug Anxiety0.91.05.92.1-0.3-0.40.6-0.40.6-0.7-0.70.32.40.60.40.2
Baseline Anxiety1.42.34.4-2.0-1.4-2.01.7-2.11.6-1.7-2.01.31.0-0.4-0.6-0.6
Tail length0.94.69.3-0.5-2.7-3.12.8-2.42.0-2.6-2.60.82.41.61.30.7
Length with tail1.35.818.10.3-2.1-2.82.8-3.03.2-2.1-3.02.24.3-0.0-0.1-0.3
Length without tail0.42.312.51.70.4-0.50.6-1.21.7-0.1-1.11.63.5-1.4-1.6-1.1
Times rat made contact with spout0.20.21.20.50.0-0.60.6-0.30.4-0.4-0.60.31.10.30.1-0.5
Lifetime Intake1.82.26.6-2.6-0.8-1.30.9-1.71.9-0.9-1.52.00.2-1.3-1.2-1.6
Liver weight, left1.22.15.40.2-1.9-1.31.7-1.81.5-1.8-1.81.32.30.20.10.4
Liver weight, right0.40.71.81.30.4-0.70.70.2-1.0-0.6-0.2-0.71.11.10.80.7
Locomotor activity1.21.94.2-1.7-1.8-1.72.0-1.50.7-2.0-1.50.60.11.01.00.7
Locomotor testing distance0.92.24.9-2.2-2.2-1.52.0-1.60.8-2.0-1.50.7-0.30.91.00.8
Locomotor testing rearing0.31.03.1-1.8-1.5-1.21.0-1.00.1-1.0-0.80.3-1.00.40.60.6
Locomotion in novel chamber0.30.41.30.7-1.1-0.50.7-0.7-0.3-0.9-0.5-0.30.80.0-0.30.8
Locomotion in novel chamber post-restriction0.10.30.7-0.1-0.8-0.40.6-0.50.4-0.5-0.50.40.80.40.60.6
Fecal boli incidents, locomotor time 10.10.20.30.60.20.3-0.40.6-0.30.20.4-0.4-0.20.50.50.5
Change in fecal boli incidents, locomotor task0.20.21.20.6-0.1-0.80.4-0.50.4-0.3-0.50.21.10.0-0.00.0
Time >=10cm from walls, locomotor time 10.30.41.30.91.20.4-0.40.4-0.50.40.4-0.50.2-0.5-0.9-0.5
Bouts of movement, locomotor time 10.50.61.90.41.41.0-1.00.9-0.51.00.8-0.3-0.5-0.5-0.6-0.6
Total resting periods, locomotor time 10.50.51.90.71.40.9-0.80.7-0.30.80.6-0.10.0-0.5-0.7-0.8
Rest time, locomotor task time 10.10.10.6-0.20.8-0.0-0.10.4-0.50.20.3-0.5-0.50.2-0.1-0.2
Distance moved, locomotor task time 10.30.82.5-0.1-0.7-0.20.5-1.11.3-0.3-0.91.31.6-1.0-0.9-0.6
Vertical activity count, locomotor time 10.10.51.0-0.4-0.70.1-0.0-0.70.9-0.1-0.51.00.7-1.0-0.9-0.6
Time >=10cm from walls, locomotor time 20.10.31.0-0.0-0.4-0.90.9-0.60.2-0.8-0.7-0.01.00.30.00.1
Bouts of movement, locomotor time 20.10.20.60.0-0.4-0.70.4-0.2-0.0-0.6-0.3-0.20.20.70.60.3
Total resting periods, locomotor time 20.00.10.20.30.0-0.30.10.1-0.2-0.2-0.0-0.30.00.50.30.1
Rest time, locomotor task time 20.30.51.7-0.31.10.3-0.50.20.40.60.10.5-0.1-0.9-1.0-1.3
Distance moved, locomotor task time 20.00.10.2-0.1-0.40.00.3-0.30.1-0.1-0.10.10.5-0.2-0.10.3
Vertical activity count, locomotor time 20.10.31.5-1.2-0.8-0.50.6-0.4-0.1-0.5-0.3-0.1-0.50.40.50.5
Light reinforcement 10.21.12.8-1.1-1.1-1.01.3-0.5-0.2-1.1-0.6-0.4-0.31.61.71.2
Light reinforcement 20.40.92.5-0.8-1.1-0.70.8-0.3-0.1-1.1-0.5-0.5-0.41.61.61.2
Bone: marrow area3.07.316.0-4.0-4.0-2.02.8-3.53.1-2.8-3.13.11.2-0.9-0.6-0.6
Bone: maximum diameter1.73.47.4-2.7-2.7-1.52.3-2.02.0-2.5-2.01.30.50.81.00.7
Bone: maximum force0.81.73.6-0.6-1.9-1.41.8-1.10.9-1.3-1.10.51.21.21.51.4
Bone: maximum moment1.01.84.0-0.4-2.0-1.51.8-1.00.7-1.4-1.00.21.11.41.71.8
Mean time between licks in bursts0.42.55.70.81.11.0-0.9-0.51.80.9-0.32.12.2-2.4-2.3-2.2
Mean num. licks in bursts0.30.82.10.2-1.00.3-0.00.7-0.9-0.00.7-0.9-0.91.11.41.4
Cd content in liver3.64.08.01.02.62.8-2.82.3-1.42.62.5-1.0-2.1-1.3-1.1-0.6
Co content in liver0.40.52.6-0.20.6-0.3-0.1-0.50.20.0-0.40.10.2-1.1-1.6-1.2
Cu content in liver1.01.12.9-1.4-0.3-1.71.5-1.20.8-1.4-1.50.40.40.4-0.2-0.9
Fe content in liver0.80.92.11.31.40.5-0.81.2-0.81.41.1-1.4-0.70.30.1-0.1
K content in liver1.01.02.5-0.90.2-1.61.1-0.2-1.2-1.2-0.5-1.3-1.01.50.80.6
Mg content in liver2.52.88.8-0.11.6-0.1-0.31.7-3.00.11.2-2.8-2.81.81.10.9
Mn content in liver3.43.912.40.10.1-1.11.11.2-2.2-1.30.5-2.8-1.63.53.12.6
Na content in liver0.40.41.8-1.3-0.4-0.80.9-0.5-0.4-0.4-0.4-0.3-1.20.40.3-0.1
Rb content in liver1.51.75.60.90.90.1-0.11.2-2.40.11.0-2.3-1.71.50.91.3
Se content in liver1.01.25.60.22.41.0-1.11.0-0.51.10.8-0.3-0.8-0.7-1.0-1.5
Sr content in liver0.70.62.5-0.20.20.50.2-0.40.8-0.0-0.30.80.6-1.3-1.6-1.3
Zn content in liver0.20.20.90.30.9-0.5-0.40.3-0.70.10.2-0.7-0.30.3-0.0-0.1
Bone: minimum diameter5.19.819.0-3.6-4.4-3.03.8-4.03.4-3.9-3.83.02.50.20.40.2
Time in familiar zone, hab. session 10.70.81.60.11.11.3-1.30.8-0.41.20.90.4-0.9-1.1-0.7-0.6
Time in novel zone, hab. session 10.30.30.70.1-0.6-0.70.6-0.60.4-0.8-0.7-0.20.80.5-0.0-0.0
Total zone transitions, hab. session 10.81.12.61.11.11.6-1.10.9-0.11.41.00.30.1-1.5-1.2-0.7
Total locomotion distance, hab. session 10.10.20.90.2-0.9-0.10.5-0.30.2-0.4-0.30.30.60.00.20.7
Locomotion velocity, hab. session 10.20.31.10.0-1.0-0.30.7-0.50.3-0.5-0.40.50.7-0.00.30.7
Time in familiar zone, hab. session 20.30.41.10.80.90.1-0.50.20.31.00.30.60.6-0.9-0.6-0.7
Time in novel zone, hab. session 20.40.41.2-0.1-0.8-0.10.3-0.0-0.4-1.0-0.1-0.9-0.21.10.71.0
Total zone transitions, hab. session 21.11.32.81.31.61.4-1.01.1-0.91.71.2-0.4-0.5-1.2-1.2-0.7
Total locomotion distance, hab. session 20.50.71.60.91.11.1-0.80.8-0.81.20.9-0.3-0.4-0.8-0.7-0.4
Locomotion velocity, hab. session 20.60.81.91.01.21.3-0.90.9-0.81.41.0-0.3-0.5-0.8-0.7-0.3
Novel to familiar place preference ratio0.30.41.2-0.6-1.1-0.70.5-0.70.5-0.9-0.70.40.60.40.60.5
Novelty place preference0.30.41.0-0.4-1.0-0.60.5-0.60.4-0.8-0.60.20.50.60.60.6
Time in novel zone, NPP test0.30.30.7-0.3-0.8-0.60.5-0.50.3-0.8-0.50.00.60.70.70.7
Total zone transitions, NPP test1.62.46.31.71.32.5-1.52.0-1.91.72.0-1.1-1.4-0.4-0.20.5
Total locomotion distance, NPP test0.30.41.10.80.00.9-0.20.7-1.00.30.6-0.6-0.30.30.40.8
Locomotion velocity, NPP test0.20.31.20.50.11.1-0.50.6-0.90.30.7-0.2-0.5-0.20.00.4
Intraocular pressure0.50.82.4-0.70.4-0.10.1-0.81.6-0.1-0.71.10.8-1.0-1.1-1.4
Delta distance traveled before/after self-admin0.20.20.40.30.60.6-0.60.5-0.30.60.50.1-0.3-0.3-0.1-0.1
Delta ambulatory time before/after self-admin0.10.20.40.60.30.6-0.50.20.30.50.20.70.5-0.5-0.0-0.2
Parametrial fat weight0.40.82.31.1-0.9-0.50.6-0.0-0.2-0.7-0.2-0.60.71.51.51.5
Pavlov. Cond. lever latency2.22.85.30.32.32.3-2.22.0-1.51.92.1-1.1-2.1-0.8-0.7-0.6
Pavlov. Cond. magazine entry latency2.93.78.2-0.0-2.7-2.92.5-1.40.0-2.0-1.5-0.40.82.52.52.3
Pavlov. Cond. change in total contacts2.12.25.8-1.0-2.1-2.32.4-1.50.5-1.9-1.70.30.61.31.00.5
Pavlov. Cond. index score2.43.07.1-0.4-2.7-2.52.4-1.70.7-1.9-1.80.41.21.71.71.5
Pavlov. Cond. latency score2.32.96.7-0.2-2.5-2.62.4-1.80.9-1.8-1.90.51.51.51.51.3
Pavlov. Cond. lever contacts2.32.85.7-0.5-2.3-2.42.3-2.11.4-1.8-2.11.01.90.80.70.5
Pavlov. Cond. magazine entry number2.93.78.00.22.62.6-2.30.90.51.81.11.0-0.0-2.8-2.8-2.5
Pavlov. Cond. intertrial magazine entries0.70.92.9-1.70.20.2-0.1-0.61.10.1-0.41.4-0.2-1.2-1.0-1.4
Pavlov. Cond. lever-magazine prob. diff.2.73.38.1-0.5-2.8-2.62.6-1.80.7-2.1-1.90.31.21.81.71.5
Pavlov. Cond. response bias3.64.510.0-0.4-3.2-3.02.8-1.60.2-2.3-1.8-0.40.92.72.62.4
Pavlov. Cond. lever latency0.30.40.80.70.70.9-0.60.40.20.80.50.40.3-0.8-0.7-0.7
Pavlov. Cond. magazine entry latency0.40.61.40.31.20.8-1.00.7-0.71.00.8-0.3-0.5-0.8-0.7-0.4
Pavlov. Cond. change in total contacts0.30.71.9-1.3-0.8-1.41.2-1.00.2-1.2-1.0-0.1-0.40.3-0.0-0.0
Pavlov. Cond. index score0.10.20.7-0.9-0.2-0.50.3-0.4-0.1-0.6-0.4-0.1-0.30.1-0.10.1
Pavlov. Cond. latency score0.10.20.9-0.9-0.4-0.60.5-0.50.1-0.7-0.50.0-0.20.1-0.10.0
Pavlov. Cond. lever contacts0.30.40.9-0.5-0.6-0.90.7-0.3-0.4-0.7-0.4-0.5-0.41.00.80.8
Pavlov. Cond. magazine entry number0.50.71.4-0.6-1.2-0.60.9-1.01.1-1.0-1.00.90.80.20.1-0.3
Pavlov. Cond. intertrial magazine entries1.84.09.2-2.0-3.0-1.82.4-2.42.2-2.6-2.52.01.20.50.4-0.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.7-0.1-0.40.2-0.3-0.2-0.4-0.3-0.1-0.3-0.1-0.20.0
Pavlov. Cond. response bias0.20.30.8-0.1-0.1-0.40.10.3-0.8-0.20.2-0.9-0.70.80.80.9
Time in closed arm before self-admin0.91.52.81.51.21.0-0.51.5-1.50.61.2-1.7-0.71.21.21.1
Time in closed arm after self-admin4.95.610.53.12.42.8-3.03.2-2.33.03.1-1.9-1.10.20.70.9
Time in open arm before self-admin1.72.05.51.10.60.6-0.8-0.71.50.7-0.41.62.1-2.3-2.3-1.7
Time in open arm after self-admin3.94.37.4-2.7-1.2-1.61.6-2.72.7-1.7-2.52.61.3-1.7-1.8-2.0
Bone: periosteal estimation2.86.615.7-3.3-4.0-2.53.2-3.12.5-3.2-2.92.01.30.70.90.7
Bone: periosteal perimeter3.26.210.5-2.9-3.2-2.42.7-3.23.1-2.9-3.02.52.1-0.1-0.0-0.4
Bone: post-yield work2.03.48.8-1.1-1.6-0.81.0-2.33.0-1.0-1.92.72.5-1.6-1.4-1.3
Progressive ratio test 1 active lever presses1.12.09.4-3.1-1.1-1.51.2-1.71.4-1.2-1.41.3-0.5-0.6-0.6-0.9
Progressive ratio test 1 breakpoint1.42.410.6-3.3-1.3-1.71.4-1.81.6-1.4-1.61.5-0.4-0.5-0.5-0.9
Progressive ratio test 1 inactive lever presses1.64.211.5-3.4-2.1-2.82.5-2.42.1-2.3-2.41.70.40.50.5-0.5
Progressive ratio test 2 active lever presses1.31.86.6-2.6-1.5-1.51.2-1.71.4-1.2-1.51.4-0.0-0.6-0.5-0.6
Progressive ratio test 2 breakpoint1.51.96.8-2.6-1.6-1.51.2-1.71.4-1.2-1.51.4-0.1-0.6-0.5-0.6
Progressive ratio test 2 inactive lever presses1.03.310.7-3.3-1.4-2.11.7-2.12.1-1.8-2.12.00.4-0.4-0.3-1.1
Incentive Sensitization - Responses0.41.02.6-1.3-1.6-1.20.9-1.40.9-0.9-1.10.90.4-0.4-0.5-0.0
Incentive Sensitization - Breakpoint0.40.92.6-1.3-1.6-1.20.8-1.30.8-0.9-1.00.80.2-0.5-0.5-0.0
Sum of active levers in priming session hrs 5-60.70.62.9-1.70.20.0-0.30.0-0.30.30.2-0.2-1.7-0.8-1.0-0.8
Progressive ratio0.20.51.8-0.5-0.30.5-0.50.6-0.80.40.7-0.5-1.30.30.70.9
Food seeking constrained by brief footshock0.20.20.7-0.8-0.5-0.40.1-0.30.3-0.3-0.30.7-0.4-0.5-0.3-0.3
Seeking ratio, punishment vs. effort0.51.01.7-0.9-0.4-1.31.1-1.21.2-1.0-1.21.10.9-0.5-0.8-1.1
Retroperitoneal fat weight0.10.43.21.8-0.3-0.00.40.10.00.10.0-0.41.00.40.30.7
Reaction time number correct0.10.41.3-0.3-0.20.20.6-0.51.1-0.4-0.50.60.8-0.4-0.6-0.8
Reaction time mean minus median0.10.51.9-1.4-0.4-1.20.8-0.60.4-0.9-0.80.3-0.40.50.3-0.3
Reaction time mean minus median AUC0.10.61.9-1.1-0.1-0.70.40.3-0.7-0.6-0.0-0.8-1.41.21.00.4
Reaction time num false alarms0.91.53.4-1.6-1.2-0.91.2-1.41.8-1.2-1.41.60.8-0.4-0.3-0.9
Reaction time num false alarms AUC0.71.53.0-1.5-1.5-1.01.4-1.41.7-1.4-1.41.50.8-0.10.0-0.7
Reaction time trials correct on left0.10.41.3-0.3-0.20.20.6-0.51.1-0.4-0.50.60.8-0.4-0.6-0.8
Reaction time trials on left0.10.41.3-0.4-0.30.00.7-0.51.1-0.6-0.60.60.8-0.2-0.5-0.7
Reaction time mean0.40.92.2-1.1-0.1-1.50.9-0.2-0.8-1.0-0.5-0.8-1.11.31.00.6
Reaction time mean AUC0.30.82.3-1.30.1-1.20.60.0-0.9-0.7-0.2-0.9-1.51.20.90.4
Median of all reaction times0.60.92.2-1.1-0.2-1.50.9-0.3-0.9-1.0-0.5-0.9-1.01.31.00.6
Reaction time omissions2.03.36.3-1.8-2.3-2.42.2-1.0-0.4-2.4-1.3-1.0-0.72.52.21.8
Reaction time false alarm rate0.50.71.7-1.3-1.1-0.70.8-0.91.1-0.9-0.91.10.1-0.00.2-0.3
Reaction time premature initiation rate0.50.82.0-0.2-1.3-1.40.6-1.01.1-0.7-0.90.61.10.60.80.5
Reaction time premature initiations0.41.12.7-0.6-1.5-1.30.9-1.21.6-0.9-1.20.91.30.40.60.1
Std. dev. reaction times0.20.81.9-1.0-0.2-1.10.70.1-1.0-0.8-0.2-0.9-1.31.41.10.6
Reaction time trials completed0.10.41.3-0.4-0.30.00.7-0.51.1-0.6-0.60.60.8-0.2-0.5-0.7
Reaction time trials AUC0.10.31.1-0.4-0.30.10.7-0.51.0-0.5-0.50.50.6-0.2-0.5-0.7
Run reversals in cocaine runway, females0.80.92.10.60.10.6-0.5-0.31.00.6-0.21.21.4-1.3-1.4-1.3
Run reversals in cocaine runway, males0.60.61.70.3-1.1-0.80.9-0.70.5-1.0-0.80.31.30.70.60.6
Latency to leave start box in cocaine runway0.40.62.11.40.40.8-1.00.40.21.00.60.30.9-0.9-0.6-0.3
Latency to leave start box in cocaine runway, F1.72.25.70.90.81.4-1.5-0.11.41.40.31.51.6-2.4-2.2-1.7
Latency to leave start box in cocaine runway, M1.71.63.91.0-0.5-0.70.50.8-1.7-0.30.5-1.7-0.91.92.02.0
Std. dev. time between licks in bursts0.30.61.7-0.20.30.3-0.6-0.30.80.7-0.10.90.5-1.3-1.2-1.0
Total sessions with >9 infusions2.02.55.8-2.40.3-0.90.6-1.52.0-0.5-1.31.90.2-1.9-2.0-2.3
Short access day 1 total inactive lever presses0.71.43.0-0.6-1.1-1.51.6-1.61.1-1.7-1.60.71.5-0.0-0.3-0.2
Short access day 10 total inactive lever presses0.42.66.3-2.5-1.7-1.92.0-1.81.6-2.3-1.91.30.70.60.5-0.2
Short access day 1 total infusions0.91.89.8-3.1-0.1-1.51.5-1.31.1-1.3-1.30.8-0.8-0.1-0.3-1.1
Short access day 10 total infusions0.91.54.4-2.1-0.7-1.30.9-1.51.6-0.8-1.41.50.0-0.8-0.8-1.2
Short access total infusions1.41.97.1-2.7-0.5-1.51.3-1.61.6-1.2-1.51.4-0.1-0.6-0.8-1.4
Short access day 1 locomotion1.42.47.8-2.8-1.1-2.01.8-1.91.6-1.5-1.81.30.6-0.4-0.4-0.8
Short access day 10 total locomotion0.83.46.3-2.0-2.5-2.51.6-2.42.1-1.8-2.32.11.3-0.30.0-0.3
Short access total locomotion3.65.410.5-3.2-2.0-2.61.8-3.03.0-1.9-2.82.91.4-1.3-1.2-1.7
One hour access (0.3 mA shock)0.30.31.0-0.6-0.70.6-0.70.00.10.50.30.6-0.7-1.0-0.7-0.2
Compulsive drug intake0.50.74.82.20.10.6-0.60.7-0.80.50.7-0.90.50.30.20.8
One hour access (shock baseline)0.51.23.4-1.8-0.7-0.20.2-1.11.3-0.2-0.81.7-0.1-1.5-1.3-1.3
Social response proportion2.83.511.3-0.1-0.2-1.21.5-2.12.4-1.4-2.22.23.4-1.2-1.7-2.1
Social responses0.50.71.90.0-0.7-1.11.3-0.90.5-0.9-1.00.71.40.30.2-0.1
Social time3.14.99.6-1.4-0.8-2.22.2-2.82.6-2.4-3.02.43.1-0.7-1.3-2.0
Soleus weight0.41.32.9-0.3-0.10.10.4-1.01.7-0.4-0.91.51.5-1.4-1.6-1.5
Bone: stiffness0.10.10.5-0.0-0.20.6-0.10.30.00.40.50.1-0.2-0.10.40.7
Tibialis anterior weight0.62.14.5-0.80.4-0.20.2-1.32.0-0.2-1.12.01.4-2.0-2.1-2.1
Time to tail flick, vehicle, before self-admin1.31.62.91.50.71.3-1.31.7-1.61.31.7-1.6-1.30.30.20.8
Time to tail flick, vehicle, after self-admin0.20.50.9-0.9-0.8-0.90.8-0.50.2-0.8-0.6-0.0-0.20.91.00.5
Time to tail flick, test, before self-admin0.60.72.40.41.41.0-0.60.4-0.20.60.40.00.1-1.2-1.5-1.2
Time to tail flick, test, after self-admin0.10.10.8-0.90.2-0.00.5-0.20.3-0.4-0.30.2-0.3-0.1-0.3-0.5
Delta time to tail flick, vehicle, before/after SA1.81.93.3-1.8-1.7-1.71.8-1.61.1-1.8-1.71.00.60.60.60.1
Delta time to tail flick, test, before/after SA0.70.91.9-1.2-1.3-1.21.4-1.00.6-1.3-1.00.30.00.70.60.4
Tibia length0.41.06.52.50.60.1-0.20.70.01.00.6-0.11.80.50.90.7
Ambulatory time before self-admin0.20.52.6-1.6-0.7-0.80.6-0.40.0-0.7-0.4-0.2-0.90.40.40.4
Ambulatory time after self-admin0.00.10.2-0.4-0.3-0.30.1-0.10.1-0.2-0.10.1-0.10.20.50.4
Bone: tissue strength0.91.03.01.71.11.3-1.11.3-0.41.31.2-0.5-0.00.10.40.4
Total heroin consumption0.91.13.5-1.9-1.4-1.11.3-0.90.1-1.5-0.9-0.2-0.70.70.40.4
Bone: trabecular number2.24.17.6-0.1-2.5-2.82.4-1.50.4-2.6-1.8-0.31.52.72.52.2
Bone: trabecular spacing1.01.53.60.01.31.6-1.50.8-0.21.61.00.6-0.8-1.9-1.6-1.4
Bone: trabecular thickness1.41.93.3-0.7-1.6-1.81.8-1.61.8-1.5-1.70.71.70.70.60.3
Bone: trabecular tissue density0.61.12.71.60.40.8-0.51.3-1.20.71.1-1.3-0.60.91.01.1
Water consumed over 24 hours0.10.10.40.60.50.20.20.4-0.2-0.10.1-0.30.30.50.4-0.1
Number of responses in last shaping day1.92.55.3-2.0-1.5-1.51.5-2.02.3-1.3-1.92.11.3-0.5-0.4-1.0