Hub : Genes

Hexim2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Hexim2	0.03	0.02	6.5e-03	0.02	0.01	0.01	0.01	5.6e-03	1.5e-02	7.6e-03	4.4e-02
2	NAcc	alternative TSS	NM_001107054.2	0.03	0.02	3.9e-04	0.02	0.02	0.02	0	1.8e-04	4.3e-04	7.4e-04	2.8e-01
3	IL	alternative TSS	XM_063269173.1	0.2	0.1	5.0e-04	0.11	0.02	0.07	-0.01	1.6e-03	9.2e-02	9.8e-03	5.2e-01
4	NAcc	alternative TSS	XM_063269173.1	0.02	0.02	4.5e-03	0.01	0.02	0.01	0.01	2.7e-02	1.4e-03	3.8e-03	1.9e-02
5	Liver	gene expression	Hexim2	0.06	0.03	4.9e-07	0.06	0.05	0.06	0.05	4.8e-07	7.2e-06	8.7e-07	1.7e-06
6	pVTA	mRNA stability	Hexim2	0.03	0.02	9.3e-03	0.04	0.02	0.03	0.03	6.3e-04	7.0e-03	4.2e-03	3.6e-03
7	NAcc	isoform ratio	XM_006247516.5	0.02	0.02	8.4e-03	0	0.01	0	0	1.2e-01	2.4e-02	1.4e-01	5.3e-02
8	Liver	alternative TSS	XM_006247515.5	0.04	0.02	1.1e-03	-0	0.01	-0	0	4.6e-01	5.3e-02	6.0e-01	3.3e-01
9	RMTg	isoform ratio	XM_006247518.5	0.3	0.14	5.1e-03	-0.01	-0	-0.01	-0	9.6e-01	4.7e-01	5.9e-01	3.6e-01
10	NAcc	gene expression	Hexim2	0.03	0.02	2.3e-04	0.03	0.03	0.03	0.03	6.0e-05	5.2e-05	9.9e-05	7.2e-05
11	pVTA	gene expression	Hexim2	0.06	0.04	1.6e-03	0.02	0.03	0.03	0.02	1.1e-02	1.2e-03	2.3e-03	4.4e-03
12	PL	gene expression	Hexim2	0.11	0.07	1.0e-05	0.02	0.04	0.03	0.03	1.3e-03	1.7e-05	9.4e-04	2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	1.4	2.5	5.0	1.6	1.9	-1.8	-0.9	-0.2	1.8	-1.2	-0.5	1.1	2.2	2.1	1.8
Area under the delay curve	0.1	0.1	0.2	0.0	-0.1	0.3	-0.2	-0.2	-0.1	-0.1	0.3	-0.2	-0.5	-0.4	-0.4
BMI with tail	0.8	2.7	7.3	-0.3	-1.0	0.8	-0.7	-2.2	-0.7	-0.4	2.7	1.8	-2.6	-2.0	-1.9
BMI without tail	1.1	3.3	10.1	1.3	0.6	-0.6	-2.0	-3.2	0.7	-1.7	2.9	2.4	-1.6	-1.1	-1.3
Body weight	2.1	9.2	26.1	1.8	1.9	-2.0	-3.4	-4.6	1.5	-3.2	4.2	5.1	-2.1	-1.8	-1.9
Weight adjusted by age	0.3	0.5	1.5	0.4	-0.1	-0.5	-0.7	-0.7	0.2	-0.6	0.7	0.6	-0.9	-1.2	-0.9
Bone surface	3.3	6.1	12.6	3.1	2.9	-3.5	-2.6	-1.7	3.4	-2.8	0.9	2.0	1.9	1.7	1.3
Bone volume	2.3	4.1	7.6	2.7	2.4	-2.7	-1.8	-1.1	2.7	-2.0	0.4	1.4	2.0	1.9	1.7
Breakpoint value in progressive ratio session	0.4	0.5	1.2	0.6	1.0	-0.9	-0.8	-0.3	1.1	-0.8	0.1	-1.0	0.3	0.1	-0.3
Number of licking bursts	0.9	1.5	4.2	-1.1	0.3	-0.1	-0.9	-1.3	-0.0	-0.9	1.4	1.5	-1.4	-1.7	-2.0
Context. condit. distance diff. score	1.1	1.3	2.9	-1.4	-1.5	1.5	0.8	0.2	-1.7	1.1	0.1	0.3	-1.5	-1.3	-0.8
Locomotion velocity, session 1	0.4	0.4	1.4	0.8	-0.4	-0.2	0.4	0.7	0.4	0.4	-0.7	-0.3	0.7	0.9	1.2
Locomotion distance, session 1	0.3	0.4	1.2	0.4	-0.7	0.2	0.6	1.0	-0.2	0.7	-0.5	-0.7	0.4	0.7	1.1
Locomotion velocity, session 2	1.4	1.7	4.5	0.2	-0.6	0.5	1.2	2.1	-0.1	1.2	-1.9	-1.3	1.3	1.3	1.9
Locomotion distance, session 2	0.6	0.8	2.3	0.4	-0.6	-0.1	0.7	1.5	0.0	0.7	-0.9	-1.1	0.8	1.0	1.4
Locomotion velocity, session 3	0.1	0.1	0.4	0.1	-0.1	-0.4	0.2	0.0	-0.2	0.2	-0.3	0.6	0.4	0.4	0.6
Locomotion distance, session 3	0.2	0.2	0.5	-0.5	-0.0	-0.4	-0.3	-0.3	-0.3	-0.2	0.3	0.7	-0.5	-0.7	-0.6
Stereotopy head waving bouts, day 3	1.2	1.4	2.2	-0.4	-1.3	1.2	1.5	1.2	-0.8	1.5	-1.3	-1.1	0.8	1.1	1.3
Stereotopy head waving duration, day 3	0.9	1.1	2.1	-0.8	-1.2	1.3	1.3	0.9	-0.9	1.4	-1.0	-1.5	0.3	0.6	0.8
Locomotion velocity, session 7	0.7	0.7	1.9	-1.0	-0.8	0.7	1.2	0.7	-1.4	1.2	-0.9	-0.1	0.1	0.2	0.4
Locomotion distance, session 7	0.4	0.5	1.3	-0.9	-0.8	0.6	0.8	0.8	-1.1	1.0	-0.6	-0.2	-0.3	-0.3	0.2
Stereotopy head waving bouts, day 7	0.4	0.5	1.6	-0.6	0.6	-0.6	0.4	0.7	0.5	-0.0	-1.1	-0.4	1.3	0.8	0.4
Stereotopy head waving duration, day 7	0.7	0.9	2.2	-1.3	0.0	0.0	1.0	1.3	-0.1	0.7	-1.5	-1.2	1.2	0.8	0.4
Locomotion velocity, session 8	0.4	0.4	2.6	0.0	-1.6	0.7	0.6	-0.2	-0.5	0.7	0.4	0.4	-0.6	0.0	0.4
Locomotion distance, session 8	0.9	1.3	3.0	-0.8	-1.7	1.1	1.4	1.4	-1.4	1.5	-0.9	-1.0	-0.4	-0.1	0.6
Degree of sensitization distance	0.1	0.1	0.3	0.1	-0.3	0.6	0.1	-0.0	-0.2	0.2	0.2	0.4	-0.5	-0.3	0.2
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.8	0.7	-0.6	0.3	0.7	0.4	-0.1	-0.9	-0.1	0.9	0.2	-0.1
Conditioned locomotion	0.0	0.0	0.2	-0.3	0.3	0.0	-0.0	-0.1	-0.1	-0.0	-0.2	0.4	0.2	0.1	0.1
Cocaine response after cond. corrected	0.3	0.4	3.2	0.2	0.8	-0.2	-0.3	-0.2	0.0	-0.4	0.0	1.8	0.3	0.1	0.3
Cocaine response after cond. not corrected	0.8	0.9	3.9	0.6	1.4	-0.8	-0.4	0.2	0.4	-0.6	-0.6	2.0	1.2	0.8	0.9
Cocaine response before conditioning	0.5	0.6	1.7	0.7	0.4	-0.8	0.1	0.7	0.6	-0.1	-0.9	-0.3	1.3	1.1	1.0
Saline control response	0.3	0.5	0.9	0.7	0.6	-0.9	-0.9	-0.9	0.8	-0.9	0.9	0.1	-0.1	0.1	-0.4
Bone: connectivity density	2.1	3.2	6.1	2.0	2.3	-2.3	-1.4	-0.2	2.5	-1.7	-0.3	1.1	2.2	1.9	1.6
Bone: cortical apparent density	5.3	7.2	14.9	-2.4	-2.1	2.2	3.4	3.9	-2.4	3.2	-3.3	-3.5	1.4	1.5	1.6
Bone: cortical area	1.5	2.3	4.0	2.0	1.7	-2.0	-1.1	-0.8	1.9	-1.3	0.2	0.8	1.7	1.8	1.5
Bone: cortical porosity	9.1	9.8	18.4	4.3	3.6	-4.0	-3.8	-3.0	3.9	-3.8	2.1	3.0	1.2	1.0	0.8
Bone: cortical porosity	6.7	7.2	13.0	3.6	2.8	-3.2	-3.3	-2.9	3.1	-3.2	2.3	3.3	0.6	0.6	0.5
Bone: cortical thickness	1.2	2.0	4.8	-0.8	0.3	0.1	1.4	1.7	-0.4	1.0	-2.1	0.0	2.2	2.1	2.0
Bone: cortical thickness	1.7	2.0	5.6	-0.4	1.0	-0.9	0.8	1.7	0.4	0.4	-2.4	-0.0	2.3	1.9	1.9
Bone: cortical tissue density	5.2	7.1	14.7	-2.3	-2.0	2.2	3.4	3.8	-2.3	3.1	-3.2	-3.6	1.4	1.5	1.5
Condit. Reinf. active minus inactive responses	0.9	1.0	2.0	1.2	1.4	-1.3	-1.4	-0.6	1.2	-1.3	0.8	0.1	-0.1	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.2	0.5	-0.6	-0.7	-0.1	0.4	-0.6	0.3	-0.2	-0.5	-0.8	-0.6
Condit. Reinf. active responses	0.6	0.8	2.2	1.5	1.3	-1.2	-1.1	-0.4	1.1	-1.0	0.4	-0.3	0.4	0.5	0.3
Condit. Reinf. inactive responses	0.7	0.8	3.2	1.0	0.5	-0.5	0.1	0.2	0.6	0.0	-0.4	-0.3	1.4	1.8	1.6
Incentive salience index mean	0.9	1.1	2.4	1.4	1.5	-1.5	-1.3	-0.5	1.3	-1.3	0.5	-0.1	0.4	0.2	-0.1
Condit. Reinf. lever presses	0.3	0.5	1.1	1.0	0.8	-0.9	-0.3	0.3	0.5	-0.4	-0.2	-0.4	1.0	1.0	0.6
Condit. Reinf. active minus inactive responses	2.6	3.4	7.1	2.7	2.4	-2.5	-1.8	-0.4	2.6	-1.9	-0.0	0.8	1.7	1.4	1.5
Condit. Reinf. active-inactive response ratio	2.4	2.7	6.0	2.3	2.3	-2.2	-2.0	-0.8	2.4	-2.0	0.5	0.8	1.0	0.6	0.5
Condit. Reinf. active responses	2.6	3.7	8.4	2.9	2.5	-2.6	-1.8	-0.3	2.7	-1.8	-0.2	0.3	1.8	1.6	1.7
Condit. Reinf. inactive responses	0.9	1.2	3.0	1.2	0.5	-0.8	0.2	0.9	0.6	0.2	-1.0	-1.2	1.5	1.7	1.7
Condit. Reinf. lever presses	0.9	1.2	2.8	1.7	1.5	-1.3	-0.8	0.1	1.3	-0.8	-0.4	-0.7	1.2	1.2	1.2
Condit. Reinf. lever reinforcers received	2.2	3.1	7.0	2.6	2.3	-2.4	-1.5	-0.1	2.4	-1.5	-0.3	0.1	1.8	1.6	1.7
Conditioned reinforcement - actives	0.1	0.2	0.6	0.0	0.8	-0.4	-0.6	-0.5	0.2	-0.6	0.6	-0.5	-0.3	-0.2	-0.6
Conditioned reinforcement - inactives	0.9	1.4	2.3	1.0	1.5	-1.2	-1.4	-1.3	1.4	-1.5	1.1	1.4	0.5	0.6	0.1
Conditioned locomotion	1.3	1.7	3.4	1.1	1.5	-1.2	-1.8	-1.6	0.9	-1.7	1.6	1.2	-0.8	-0.8	-1.0
Patch foraging indifference point 0 sec	1.1	2.1	6.7	1.4	1.1	-1.2	0.0	0.4	0.7	-0.1	-1.2	-0.2	2.2	2.6	2.6
Patch foraging indifference point AUC	0.6	0.8	2.1	0.1	1.2	-0.6	-1.2	-0.7	0.6	-1.2	1.0	1.4	-0.5	-0.7	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	-0.2	-0.3	0.4	0.3	0.6	-0.4	0.4	-0.4	-0.9	-0.2	-0.2	0.0
Delay disc. indifference point, 16s delay	0.5	0.6	1.6	-0.2	-0.2	0.5	-0.4	-0.8	-0.3	-0.2	1.0	0.5	-1.3	-1.2	-1.1
Delay disc. indifference point, 2s delay	0.6	0.7	2.6	1.6	0.7	-0.9	-0.6	0.0	1.1	-0.6	-0.2	-0.2	0.9	0.9	1.0
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	0.3	0.4	-0.3	-0.7	-0.5	0.4	-0.6	0.6	0.8	-0.5	-0.7	-0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.1	-0.1	0.4	0.1	0.1	-0.2	0.2	-0.1	-0.6	-0.4	-0.3	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.2	-0.4	0.5	0.5	0.5	-0.2	0.5	-0.5	-0.7	0.3	0.3	0.2
Indifference point function ln k	0.5	0.8	2.0	1.4	0.5	-1.1	-0.2	-0.2	1.0	-0.3	-0.6	-0.2	1.4	1.3	1.2
Indifference point function log k	0.5	0.8	2.0	1.4	0.5	-1.1	-0.2	-0.2	1.0	-0.3	-0.6	-0.2	1.4	1.3	1.2
Patch foraging total patch changes 0 sec	1.2	2.2	6.9	1.7	1.2	-1.3	-0.1	0.2	1.0	-0.2	-0.9	-0.1	2.2	2.6	2.6
Patch foraging total patch changes 12 sec	1.1	1.4	4.0	1.2	1.2	-1.0	-0.2	0.7	0.8	-0.3	-0.7	-0.4	1.7	2.0	2.0
Patch foraging total patch changes 18 sec	0.2	0.3	0.7	0.5	0.8	-0.8	-0.6	-0.2	0.5	-0.6	0.1	0.4	0.4	0.4	0.6
Patch foraging total patch changes 24 sec	0.9	1.6	4.8	1.2	1.1	-1.3	-0.2	0.2	1.0	-0.3	-0.8	-0.0	2.0	2.2	2.1
Patch foraging total patch changes 6 sec	0.5	0.8	2.2	0.8	1.5	-1.1	-0.5	0.4	0.6	-0.6	-0.3	0.5	1.1	1.2	1.2
Patch foraging time to switch 0 sec	0.1	0.3	0.7	-0.4	-0.5	0.8	0.5	0.7	-0.8	0.6	-0.3	-0.5	-0.4	-0.3	0.1
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.6	0.0	-0.7	-0.1	-0.5	0.4	-0.2	0.2	0.5	0.3	0.4	0.4
Patch foraging water rate 12 sec	0.1	0.1	1.1	-0.4	-0.2	-0.1	0.2	-0.2	-0.0	0.1	-0.3	1.0	-0.1	-0.4	-0.2
Patch foraging water rate 18 sec	1.1	1.6	4.4	-0.0	-0.6	0.2	1.3	1.2	-0.1	1.0	-1.8	0.1	1.9	1.9	2.1
Patch foraging water rate 24 sec	1.0	1.4	2.4	-0.4	-1.1	0.9	1.5	1.4	-0.9	1.5	-1.6	-1.3	0.8	0.9	1.3
Patch foraging water rate 6 sec	0.6	0.8	1.9	1.4	0.7	-1.4	-0.6	-0.6	1.2	-0.7	-0.2	0.7	1.0	0.8	0.7
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	5.0	0.2	0.3	0.2	-1.4	-1.8	-0.2	-1.0	2.2	1.3	-2.2	-2.0	-1.7
Distance traveled before self-admin	0.2	0.2	1.3	0.5	0.5	-0.3	-0.2	0.2	0.5	-0.1	-0.3	-1.1	0.3	0.3	0.4
Distance traveled after self-admin	0.2	0.2	1.2	-0.2	-0.4	0.6	0.3	0.4	-0.4	0.5	-0.0	-1.1	-0.5	-0.2	0.1
Extensor digitorum longus weight	2.8	11.1	29.0	-3.6	-3.2	3.2	0.7	-1.5	-3.6	1.4	2.3	0.4	-5.4	-5.1	-4.5
Bone: elastic displacement	0.4	0.5	1.6	0.1	1.3	-0.8	-0.4	0.0	0.7	-0.7	-0.4	1.0	1.0	0.5	0.3
Bone: elastic work	1.6	2.0	5.6	1.5	2.4	-2.0	-1.2	-0.4	1.5	-1.5	-0.0	1.4	1.5	1.3	0.9
Bone: endosteal estimation	3.1	6.8	15.9	4.0	2.0	-2.9	-3.6	-3.2	2.9	-3.1	3.1	1.2	-0.9	-0.6	-0.6
Bone: endosteal perimeter	5.3	11.2	20.4	4.3	2.7	-3.4	-4.5	-4.5	3.9	-4.2	4.1	2.2	-1.0	-0.8	-1.2
Epididymis fat weight	0.1	0.4	1.2	0.3	-0.4	-0.3	-0.5	-0.7	-0.0	-0.4	1.1	1.0	-0.8	-0.8	-0.7
Delta time in closed arm before/after self-admin	1.6	1.5	4.8	-1.1	-1.4	2.2	1.7	0.6	-2.1	1.7	-0.2	-0.0	-0.4	0.2	0.0
Delta time in open arm before/after self-admin	0.6	0.6	4.5	0.0	0.4	-0.6	-0.5	-0.2	0.5	-0.4	0.4	-2.1	-0.4	-0.4	-0.8
Diff in mean of infusions in LGA sessions	0.2	0.2	0.7	0.5	0.6	-0.6	-0.5	-0.1	0.8	-0.5	0.1	-0.5	0.3	0.2	0.0
Delay discount exponential model param	0.1	0.1	0.3	-0.1	-0.0	-0.2	0.3	0.4	-0.0	0.2	-0.5	0.0	0.5	0.5	0.4
Extinction: sum of active levers before priming	0.0	0.0	0.3	-0.1	0.3	0.2	-0.1	-0.1	-0.1	-0.0	0.1	-0.6	-0.0	0.3	-0.1
Active lever presses in extinction session 6	3.2	3.1	6.1	1.4	2.1	-2.0	-2.5	-2.1	2.1	-2.4	2.0	0.9	-0.4	-0.5	-1.1
Bone: final force	1.3	2.0	5.7	1.2	1.2	-1.7	-0.1	0.5	1.1	-0.3	-0.9	0.3	2.2	2.4	2.3
Bone: final moment	1.5	2.5	6.9	1.3	1.3	-1.7	-0.0	0.6	1.2	-0.3	-1.1	0.3	2.5	2.6	2.6
Food consumed during 24 hour testing period	0.5	0.7	1.6	0.6	0.4	-0.6	-0.9	-1.3	0.6	-0.9	1.2	1.2	-0.6	-0.6	-1.0
Glucose	0.9	1.4	3.5	-1.4	-1.9	1.7	1.3	0.7	-1.5	1.4	-0.2	-0.5	-1.1	-0.9	-0.5
Heart weight	2.7	4.2	14.8	-0.3	0.6	-0.7	-1.8	-3.6	0.5	-1.7	2.5	3.8	-1.5	-1.7	-2.1
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.3	-0.1	-0.0	0.4	0.3	-0.2	0.3	-0.4	0.1	0.4	0.3	0.3
Intermittent access intake day 1-15 change	0.5	1.0	3.4	-0.1	-1.9	1.5	0.9	-0.0	-1.3	1.1	0.5	-0.3	-1.1	-0.6	-0.3
Intermittent access intake escalation	0.4	0.9	3.2	0.3	-1.8	1.4	0.9	0.1	-1.3	1.2	0.4	-0.4	-0.9	-0.3	0.1
Intermittent access intake escalation 2	0.4	0.5	1.9	0.5	-1.4	0.9	0.4	-0.5	-0.9	0.7	0.8	0.1	-0.8	-0.2	-0.0
Intermitt. access day 1 inactive lever presses	1.2	4.5	7.6	2.3	2.5	-2.6	-2.6	-2.8	2.6	-2.7	2.4	0.9	0.2	0.2	-0.9
Intermitt. access day 15 inactive lever presses	1.4	2.8	6.6	2.5	2.0	-2.4	-1.9	-0.7	2.6	-1.9	0.7	-0.4	1.1	0.8	0.5
Intermitt. access escalation Index	0.5	0.7	2.0	-0.6	-0.8	0.1	-0.1	-0.7	-0.2	-0.0	0.8	-0.7	-1.2	-1.3	-1.4
Intermittent access day 1 total infusions	0.5	0.8	1.6	-0.0	1.2	-0.6	-1.1	-1.0	0.5	-1.0	1.0	-0.3	-0.8	-0.8	-1.2
Intermittent access day 15 total infusions	0.5	0.8	2.5	0.8	-0.1	0.5	-0.5	-1.1	-0.4	-0.1	1.5	-0.8	-1.6	-1.0	-0.9
Intermittent access terminal intake (last 3 days)	0.9	1.2	2.9	1.1	0.6	-0.4	-1.3	-1.5	0.4	-0.9	1.7	-0.8	-1.4	-1.0	-1.1
Intermittent access total infusions	1.4	1.6	4.1	0.6	0.8	-0.4	-1.4	-1.7	0.3	-1.1	2.0	-0.1	-1.7	-1.4	-1.6
Intermittent access day 1 locomotion	1.3	1.7	3.5	1.1	1.9	-1.0	-1.8	-1.6	1.0	-1.7	1.7	0.8	-0.8	-0.6	-0.8
Intermittent access day 15 total locomotion	0.3	0.5	1.4	0.7	0.3	0.4	-0.6	-0.6	-0.4	-0.3	1.2	0.7	-1.2	-0.6	-0.3
Intermittent access total locomotion	1.5	1.8	3.4	1.7	1.5	-0.8	-1.8	-1.6	0.9	-1.6	1.9	1.2	-1.1	-0.7	-0.6
Intermittent access standard deviation	0.1	0.1	0.4	0.6	0.1	0.1	-0.1	-0.4	-0.1	-0.0	0.6	-0.7	0.0	0.4	-0.0
Left kidney weight	0.1	0.5	4.9	0.0	0.2	-0.4	-0.2	-0.7	-0.1	-0.3	0.2	2.2	0.1	-0.1	0.2
Right kidney weight	0.4	1.8	9.9	0.1	0.9	-0.7	-1.2	-2.0	0.4	-1.2	1.2	3.2	-0.6	-0.9	-0.8
Cocaine induced anxiety	0.2	0.4	1.3	-0.6	-0.8	0.4	0.8	0.4	-0.3	0.5	-0.5	1.2	0.6	0.4	0.3
Post-drug Anxiety	0.7	0.7	5.9	0.3	0.4	-0.6	-0.4	-0.6	0.7	-0.7	0.3	2.4	0.6	0.4	0.2
Baseline Anxiety	1.9	2.2	4.4	1.4	2.0	-1.7	-2.1	-1.6	1.7	-2.0	1.3	1.0	-0.4	-0.6	-0.6
Tail length	1.3	5.0	9.3	2.7	3.1	-2.8	-2.4	-2.0	2.6	-2.6	0.8	2.4	1.6	1.3	0.7
Length with tail	1.5	6.3	18.1	2.1	2.8	-2.8	-3.0	-3.2	2.1	-3.0	2.2	4.3	-0.0	-0.1	-0.3
Length without tail	0.7	2.3	12.5	-0.4	0.5	-0.6	-1.2	-1.7	0.1	-1.1	1.6	3.5	-1.4	-1.6	-1.1
Times rat made contact with spout	0.2	0.2	1.2	-0.0	0.6	-0.6	-0.3	-0.4	0.4	-0.6	0.3	1.1	0.3	0.1	-0.5
Lifetime Intake	1.5	1.9	3.9	0.8	1.3	-0.9	-1.7	-1.9	0.9	-1.5	2.0	0.2	-1.3	-1.2	-1.6
Liver weight, left	1.4	2.3	5.4	1.9	1.3	-1.7	-1.8	-1.5	1.8	-1.8	1.3	2.3	0.2	0.1	0.4
Liver weight, right	0.3	0.6	1.3	-0.4	0.7	-0.7	0.2	1.0	0.6	-0.2	-0.7	1.1	1.1	0.8	0.7
Locomotor activity	1.2	1.9	4.2	1.8	1.7	-2.0	-1.5	-0.7	2.0	-1.5	0.6	0.1	1.0	1.0	0.7
Locomotor testing distance	1.1	2.0	4.7	2.2	1.5	-2.0	-1.6	-0.8	2.0	-1.5	0.7	-0.3	0.9	1.0	0.8
Locomotor testing rearing	0.4	0.8	2.3	1.5	1.2	-1.0	-1.0	-0.1	1.0	-0.8	0.3	-1.0	0.4	0.6	0.6
Locomotion in novel chamber	0.3	0.4	1.3	1.1	0.5	-0.7	-0.7	0.3	0.9	-0.5	-0.3	0.8	0.0	-0.3	0.8
Locomotion in novel chamber post-restriction	0.2	0.3	0.7	0.8	0.4	-0.6	-0.5	-0.4	0.5	-0.5	0.4	0.8	0.4	0.6	0.6
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.2	-0.3	0.4	0.6	0.3	-0.2	0.4	-0.4	-0.2	0.5	0.5	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	1.2	0.1	0.8	-0.4	-0.5	-0.4	0.3	-0.5	0.2	1.1	0.0	-0.0	0.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.3	-1.2	-0.4	0.4	0.4	0.5	-0.4	0.4	-0.5	0.2	-0.5	-0.9	-0.5
Bouts of movement, locomotor time 1	0.6	0.7	1.9	-1.4	-1.0	1.0	0.9	0.5	-1.0	0.8	-0.3	-0.5	-0.5	-0.6	-0.6
Total resting periods, locomotor time 1	0.5	0.5	1.9	-1.4	-0.9	0.8	0.7	0.3	-0.8	0.6	-0.1	0.0	-0.5	-0.7	-0.8
Rest time, locomotor task time 1	0.1	0.1	0.6	-0.8	0.0	0.1	0.4	0.5	-0.2	0.3	-0.5	-0.5	0.2	-0.1	-0.2
Distance moved, locomotor task time 1	0.6	0.9	2.5	0.7	0.2	-0.5	-1.1	-1.3	0.3	-0.9	1.3	1.6	-1.0	-0.9	-0.6
Vertical activity count, locomotor time 1	0.2	0.5	1.0	0.7	-0.1	0.0	-0.7	-0.9	0.1	-0.5	1.0	0.7	-1.0	-0.9	-0.6
Time >=10cm from walls, locomotor time 2	0.2	0.4	1.0	0.4	0.9	-0.9	-0.6	-0.2	0.8	-0.7	-0.0	1.0	0.3	0.0	0.1
Bouts of movement, locomotor time 2	0.1	0.2	0.6	0.4	0.7	-0.4	-0.2	0.0	0.6	-0.3	-0.2	0.2	0.7	0.6	0.3
Total resting periods, locomotor time 2	0.0	0.1	0.2	-0.0	0.3	-0.1	0.1	0.2	0.2	-0.0	-0.3	0.1	0.5	0.3	0.1
Rest time, locomotor task time 2	0.4	0.5	1.7	-1.1	-0.3	0.5	0.2	-0.4	-0.6	0.1	0.5	-0.1	-0.9	-1.0	-1.3
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	-0.0	-0.3	-0.3	-0.1	0.1	-0.1	0.1	0.5	-0.2	-0.1	0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.8	0.5	-0.6	-0.4	0.1	0.5	-0.3	-0.1	-0.5	0.4	0.5	0.5
Light reinforcement 1	0.4	1.1	2.8	1.1	1.0	-1.3	-0.5	0.2	1.1	-0.6	-0.4	-0.3	1.6	1.7	1.2
Light reinforcement 2	0.6	0.9	2.5	1.1	0.7	-0.8	-0.3	0.1	1.1	-0.5	-0.5	-0.4	1.6	1.6	1.2
Bone: marrow area	3.0	6.6	15.7	4.0	2.0	-2.8	-3.5	-3.1	2.8	-3.1	3.1	1.2	-0.9	-0.6	-0.6
Bone: maximum diameter	1.7	3.1	7.4	2.7	1.5	-2.3	-2.0	-2.0	2.5	-2.0	1.3	0.5	0.8	1.0	0.7
Bone: maximum force	1.0	1.8	3.6	1.9	1.4	-1.8	-1.1	-0.9	1.3	-1.1	0.5	1.2	1.2	1.5	1.4
Bone: maximum moment	1.1	2.0	4.0	2.0	1.5	-1.8	-1.0	-0.7	1.4	-1.0	0.2	1.1	1.4	1.7	1.8
Mean time between licks in bursts	1.1	2.7	5.7	-1.1	-1.0	0.9	-0.5	-1.8	-0.9	-0.3	2.1	2.2	-2.4	-2.3	-2.2
Mean num. licks in bursts	0.5	0.8	2.1	1.0	-0.3	0.0	0.7	0.9	0.0	0.7	-0.9	-0.9	1.1	1.4	1.4
Cd content in liver	3.9	4.3	8.0	-2.6	-2.8	2.8	2.3	1.4	-2.6	2.5	-1.0	-2.1	-1.3	-1.1	-0.6
Co content in liver	0.4	0.5	2.6	-0.6	0.3	0.1	-0.5	-0.2	-0.0	-0.4	0.1	0.2	-1.1	-1.6	-1.2
Cu content in liver	0.9	1.1	2.9	0.3	1.7	-1.5	-1.2	-0.8	1.4	-1.5	0.4	0.4	0.4	-0.2	-0.9
Fe content in liver	0.7	0.9	2.1	-1.4	-0.5	0.8	1.2	0.8	-1.4	1.1	-1.4	-0.7	0.3	0.1	-0.1
K content in liver	1.1	1.0	2.5	-0.2	1.6	-1.1	-0.2	1.2	1.2	-0.5	-1.3	-1.0	1.5	0.8	0.6
Mg content in liver	3.0	3.0	8.8	-1.6	0.1	0.3	1.7	3.0	-0.1	1.2	-2.8	-2.8	1.8	1.1	0.9
Mn content in liver	3.8	4.2	12.4	-0.1	1.1	-1.1	1.2	2.2	1.3	0.5	-2.8	-1.6	3.5	3.1	2.6
Na content in liver	0.3	0.3	1.5	0.4	0.8	-0.9	-0.5	0.4	0.4	-0.4	-0.3	-1.2	0.4	0.3	-0.1
Rb content in liver	1.5	1.8	5.6	-0.9	-0.1	0.1	1.2	2.4	-0.1	1.0	-2.3	-1.7	1.5	0.9	1.3
Se content in liver	1.1	1.2	5.6	-2.4	-1.0	1.1	1.0	0.5	-1.1	0.8	-0.3	-0.8	-0.7	-1.0	-1.5
Sr content in liver	0.8	0.7	2.5	-0.2	-0.5	-0.2	-0.4	-0.8	0.0	-0.3	0.8	0.6	-1.3	-1.6	-1.3
Zn content in liver	0.2	0.2	0.9	-0.9	0.5	0.4	0.3	0.7	-0.1	0.2	-0.7	-0.3	0.3	-0.0	-0.1
Bone: minimum diameter	5.3	9.6	19.0	4.4	3.0	-3.8	-4.0	-3.4	3.9	-3.8	3.0	2.5	0.2	0.4	0.2
Time in familiar zone, hab. session 1	0.9	0.9	1.6	-1.1	-1.3	1.3	0.8	0.4	-1.2	0.9	0.4	-0.9	-1.1	-0.7	-0.6
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.6	0.7	-0.6	-0.6	-0.4	0.8	-0.7	-0.2	0.8	0.5	-0.0	-0.0
Total zone transitions, hab. session 1	0.8	1.1	2.6	-1.1	-1.6	1.1	0.9	0.1	-1.4	1.0	0.3	0.1	-1.5	-1.2	-0.7
Total locomotion distance, hab. session 1	0.1	0.2	0.9	0.9	0.1	-0.5	-0.3	-0.2	0.4	-0.3	0.3	0.6	0.0	0.2	0.7
Locomotion velocity, hab. session 1	0.2	0.3	1.1	1.0	0.3	-0.7	-0.5	-0.3	0.5	-0.4	0.5	0.7	-0.0	0.3	0.7
Time in familiar zone, hab. session 2	0.4	0.4	1.1	-0.9	-0.1	0.5	0.2	-0.3	-1.0	0.3	0.6	0.6	-0.9	-0.6	-0.7
Time in novel zone, hab. session 2	0.5	0.5	1.2	0.8	0.1	-0.3	-0.0	0.4	1.0	-0.1	-0.9	-0.2	1.1	0.7	1.0
Total zone transitions, hab. session 2	1.0	1.3	2.8	-1.6	-1.4	1.0	1.1	0.9	-1.7	1.2	-0.4	-0.5	-1.2	-1.2	-0.7
Total locomotion distance, hab. session 2	0.5	0.7	1.6	-1.1	-1.1	0.8	0.8	0.8	-1.2	0.9	-0.3	-0.4	-0.8	-0.7	-0.4
Locomotion velocity, hab. session 2	0.6	0.8	1.9	-1.2	-1.3	0.9	0.9	0.8	-1.4	1.0	-0.3	-0.5	-0.8	-0.7	-0.3
Novel to familiar place preference ratio	0.4	0.4	1.2	1.1	0.7	-0.5	-0.7	-0.5	0.9	-0.7	0.4	0.6	0.4	0.6	0.5
Novelty place preference	0.4	0.4	1.0	1.0	0.6	-0.5	-0.6	-0.4	0.8	-0.6	0.2	0.5	0.6	0.6	0.6
Time in novel zone, NPP test	0.3	0.3	0.7	0.8	0.6	-0.5	-0.5	-0.3	0.8	-0.5	0.0	0.6	0.7	0.7	0.7
Total zone transitions, NPP test	1.6	2.4	6.3	-1.3	-2.5	1.5	2.0	1.9	-1.7	2.0	-1.1	-1.4	-0.4	-0.2	0.5
Total locomotion distance, NPP test	0.2	0.3	1.1	-0.0	-0.9	0.2	0.7	1.0	-0.3	0.6	-0.6	-0.3	0.3	0.4	0.8
Locomotion velocity, NPP test	0.2	0.3	1.2	-0.1	-1.1	0.5	0.6	0.9	-0.3	0.7	-0.2	-0.5	-0.2	0.0	0.4
Intraocular pressure	0.6	0.8	2.4	-0.4	0.1	-0.1	-0.8	-1.6	0.1	-0.7	1.1	0.8	-1.0	-1.1	-1.4
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.6	-0.6	0.6	0.5	0.3	-0.6	0.5	0.1	-0.3	-0.3	-0.1	-0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	-0.3	-0.6	0.5	0.2	-0.3	-0.5	0.2	0.7	0.5	-0.5	-0.0	-0.2
Parametrial fat weight	0.3	0.8	2.3	0.9	0.5	-0.6	-0.0	0.2	0.7	-0.2	-0.6	0.7	1.5	1.5	1.5
Pavlov. Cond. lever latency	2.4	3.0	5.3	-2.3	-2.3	2.2	2.0	1.5	-1.9	2.1	-1.1	-2.1	-0.8	-0.7	-0.6
Pavlov. Cond. magazine entry latency	3.1	4.0	8.2	2.7	2.9	-2.5	-1.4	-0.0	2.0	-1.5	-0.4	0.8	2.5	2.5	2.3
Pavlov. Cond. change in total contacts	2.2	2.3	5.8	2.1	2.3	-2.4	-1.5	-0.5	1.9	-1.7	0.3	0.6	1.3	1.0	0.5
Pavlov. Cond. index score	2.6	3.2	7.1	2.7	2.5	-2.4	-1.7	-0.7	1.9	-1.8	0.4	1.2	1.7	1.7	1.5
Pavlov. Cond. latency score	2.5	3.2	6.7	2.5	2.6	-2.4	-1.8	-0.9	1.8	-1.9	0.5	1.5	1.5	1.5	1.3
Pavlov. Cond. lever contacts	2.5	3.0	5.7	2.3	2.4	-2.3	-2.1	-1.4	1.8	-2.1	1.0	1.9	0.8	0.7	0.5
Pavlov. Cond. magazine entry number	3.1	4.0	8.0	-2.6	-2.6	2.3	0.9	-0.5	-1.8	1.1	1.0	-0.0	-2.8	-2.8	-2.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.0	-0.2	-0.2	0.1	-0.6	-1.1	-0.1	-0.4	1.4	-0.2	-1.2	-1.0	-1.4
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	8.1	2.8	2.6	-2.6	-1.8	-0.7	2.1	-1.9	0.3	1.2	1.8	1.7	1.5
Pavlov. Cond. response bias	4.0	4.9	10.0	3.2	3.0	-2.8	-1.6	-0.2	2.3	-1.8	-0.4	0.9	2.7	2.6	2.4
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.7	-0.9	0.6	0.4	-0.2	-0.8	0.5	0.4	0.3	-0.8	-0.7	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.4	-1.2	-0.8	1.0	0.7	0.7	-1.0	0.8	-0.3	-0.5	-0.8	-0.7	-0.4
Pavlov. Cond. change in total contacts	0.4	0.6	1.9	0.8	1.4	-1.2	-1.0	-0.2	1.2	-1.0	-0.1	-0.4	0.3	-0.0	-0.0
Pavlov. Cond. index score	0.1	0.1	0.3	0.2	0.5	-0.3	-0.4	0.1	0.6	-0.4	-0.1	-0.3	0.1	-0.1	0.1
Pavlov. Cond. latency score	0.1	0.1	0.4	0.4	0.6	-0.5	-0.5	-0.1	0.7	-0.5	0.0	-0.2	0.1	-0.1	0.0
Pavlov. Cond. lever contacts	0.3	0.4	0.9	0.6	0.9	-0.7	-0.3	0.4	0.7	-0.4	-0.5	-0.4	1.0	0.8	0.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.4	1.2	0.6	-0.9	-1.0	-1.1	1.0	-1.0	0.9	0.8	0.2	0.1	-0.3
Pavlov. Cond. intertrial magazine entries	2.7	4.0	9.2	3.0	1.8	-2.4	-2.4	-2.2	2.6	-2.5	2.0	1.2	0.5	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.1	0.4	-0.2	-0.3	0.2	0.4	-0.3	-0.1	-0.3	-0.1	-0.2	0.0
Pavlov. Cond. response bias	0.3	0.4	0.8	0.1	0.4	-0.1	0.3	0.8	0.2	0.2	-0.9	-0.7	0.8	0.8	0.9
Time in closed arm before self-admin	1.1	1.4	2.8	-1.2	-1.0	0.5	1.5	1.5	-0.6	1.2	-1.7	-0.7	1.2	1.2	1.1
Time in closed arm after self-admin	4.9	5.3	10.5	-2.4	-2.8	3.0	3.2	2.3	-3.0	3.1	-1.9	-1.1	0.2	0.7	0.9
Time in open arm before self-admin	1.9	2.1	5.5	-0.6	-0.6	0.8	-0.7	-1.5	-0.7	-0.4	1.6	2.1	-2.3	-2.3	-1.7
Time in open arm after self-admin	3.7	4.1	7.4	1.2	1.6	-1.6	-2.7	-2.7	1.7	-2.5	2.6	1.3	-1.7	-1.8	-2.0
Bone: periosteal estimation	3.0	6.3	15.7	4.0	2.5	-3.2	-3.1	-2.5	3.2	-2.9	2.0	1.3	0.7	0.9	0.7
Bone: periosteal perimeter	3.5	6.0	10.5	3.2	2.4	-2.7	-3.2	-3.1	2.9	-3.0	2.5	2.1	-0.1	-0.0	-0.4
Bone: post-yield work	2.5	3.6	8.8	1.6	0.8	-1.0	-2.3	-3.0	1.0	-1.9	2.7	2.5	-1.6	-1.4	-1.3
Progressive ratio test 1 active lever presses	1.1	1.4	2.7	1.1	1.5	-1.2	-1.7	-1.4	1.2	-1.4	1.3	-0.5	-0.6	-0.6	-0.9
Progressive ratio test 1 breakpoint	1.4	1.7	3.3	1.3	1.7	-1.4	-1.8	-1.6	1.4	-1.6	1.5	-0.4	-0.5	-0.5	-0.9
Progressive ratio test 1 inactive lever presses	2.5	3.6	7.8	2.1	2.8	-2.5	-2.4	-2.1	2.3	-2.4	1.7	0.4	0.5	0.5	-0.5
Progressive ratio test 2 active lever presses	1.2	1.5	2.8	1.5	1.5	-1.2	-1.7	-1.4	1.2	-1.5	1.4	-0.0	-0.6	-0.5	-0.6
Progressive ratio test 2 breakpoint	1.3	1.5	2.9	1.6	1.5	-1.2	-1.7	-1.4	1.2	-1.5	1.4	-0.1	-0.6	-0.5	-0.6
Progressive ratio test 2 inactive lever presses	1.6	2.6	4.5	1.4	2.1	-1.7	-2.1	-2.1	1.8	-2.1	2.0	0.4	-0.4	-0.3	-1.1
Incentive Sensitization - Responses	0.6	0.9	2.6	1.6	1.2	-0.9	-1.4	-0.9	0.9	-1.1	0.9	0.4	-0.4	-0.5	-0.0
Incentive Sensitization - Breakpoint	0.6	0.8	2.6	1.6	1.2	-0.8	-1.3	-0.8	0.9	-1.0	0.8	0.2	-0.5	-0.5	-0.0
Sum of active levers in priming session hrs 5-6	0.5	0.5	2.9	-0.2	-0.0	0.3	0.0	0.3	-0.3	0.2	-0.2	-1.7	-0.8	-1.0	-0.8
Progressive ratio	0.3	0.5	1.8	0.3	-0.5	0.5	0.6	0.8	-0.4	0.7	-0.5	-1.3	0.3	0.7	0.9
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.5	0.4	-0.1	-0.3	-0.3	0.3	-0.3	0.7	-0.4	-0.5	-0.3	-0.3
Seeking ratio, punishment vs. effort	0.7	1.0	1.7	0.4	1.3	-1.1	-1.2	-1.2	1.0	-1.2	1.1	0.9	-0.5	-0.8	-1.1
Retroperitoneal fat weight	0.0	0.2	1.0	0.3	0.0	-0.4	0.1	-0.0	-0.1	0.0	-0.4	1.0	0.4	0.3	0.7
Reaction time number correct	0.2	0.4	1.3	0.2	-0.2	-0.6	-0.5	-1.1	0.4	-0.5	0.6	0.8	-0.4	-0.6	-0.8
Reaction time mean minus median	0.2	0.4	1.5	0.4	1.2	-0.8	-0.6	-0.4	0.9	-0.8	0.3	-0.4	0.5	0.3	-0.3
Reaction time mean minus median AUC	0.2	0.6	1.9	0.1	0.7	-0.4	0.3	0.7	0.6	-0.0	-0.8	-1.4	1.2	1.0	0.4
Reaction time num false alarms	1.0	1.4	3.4	1.2	0.9	-1.2	-1.4	-1.8	1.2	-1.4	1.6	0.8	-0.4	-0.3	-0.9
Reaction time num false alarms AUC	0.9	1.4	3.0	1.5	1.0	-1.4	-1.4	-1.7	1.4	-1.4	1.5	0.8	-0.1	0.0	-0.7
Reaction time trials correct on left	0.2	0.4	1.3	0.2	-0.2	-0.6	-0.5	-1.1	0.4	-0.5	0.6	0.8	-0.4	-0.6	-0.8
Reaction time trials on left	0.2	0.4	1.3	0.3	-0.0	-0.7	-0.5	-1.1	0.6	-0.6	0.6	0.8	-0.2	-0.5	-0.7
Reaction time mean	0.5	0.8	2.2	0.1	1.5	-0.9	-0.2	0.8	1.0	-0.5	-0.8	-1.1	1.3	1.0	0.6
Reaction time mean AUC	0.5	0.7	2.3	-0.1	1.2	-0.6	0.0	0.9	0.7	-0.2	-0.9	-1.5	1.2	0.9	0.4
Median of all reaction times	0.6	0.8	2.2	0.2	1.5	-0.9	-0.3	0.9	1.0	-0.5	-0.9	-1.0	1.3	1.0	0.6
Reaction time omissions	2.3	3.3	6.3	2.3	2.4	-2.2	-1.0	0.4	2.4	-1.3	-1.0	-0.7	2.5	2.2	1.8
Reaction time false alarm rate	0.4	0.6	1.3	1.1	0.7	-0.8	-0.9	-1.1	0.9	-0.9	1.1	0.1	-0.0	0.2	-0.3
Reaction time premature initiation rate	0.6	0.9	2.0	1.3	1.4	-0.6	-1.0	-1.1	0.7	-0.9	0.6	1.1	0.6	0.8	0.5
Reaction time premature initiations	0.7	1.2	2.7	1.5	1.3	-0.9	-1.2	-1.6	0.9	-1.2	0.9	1.3	0.4	0.6	0.1
Std. dev. reaction times	0.4	0.8	1.9	0.2	1.1	-0.7	0.1	1.0	0.8	-0.2	-0.9	-1.3	1.4	1.1	0.6
Reaction time trials completed	0.2	0.4	1.3	0.3	-0.0	-0.7	-0.5	-1.1	0.6	-0.6	0.6	0.8	-0.2	-0.5	-0.7
Reaction time trials AUC	0.2	0.3	1.1	0.3	-0.1	-0.7	-0.5	-1.0	0.5	-0.5	0.5	0.6	-0.2	-0.5	-0.7
Run reversals in cocaine runway, females	0.9	0.9	2.1	-0.1	-0.6	0.5	-0.3	-1.0	-0.6	-0.2	1.2	1.4	-1.3	-1.4	-1.3
Run reversals in cocaine runway, males	0.7	0.7	1.7	1.1	0.8	-0.9	-0.7	-0.5	1.0	-0.8	0.3	1.3	0.7	0.6	0.6
Latency to leave start box in cocaine runway	0.4	0.5	1.0	-0.4	-0.8	1.0	0.4	-0.2	-1.0	0.6	0.3	0.9	-0.9	-0.6	-0.3
Latency to leave start box in cocaine runway, F	2.0	2.3	5.7	-0.8	-1.4	1.5	-0.1	-1.4	-1.4	0.3	1.5	1.6	-2.4	-2.2	-1.7
Latency to leave start box in cocaine runway, M	1.8	1.7	3.9	0.5	0.7	-0.5	0.8	1.7	0.3	0.5	-1.7	-0.9	1.9	2.0	2.0
Std. dev. time between licks in bursts	0.4	0.6	1.7	-0.3	-0.3	0.6	-0.3	-0.8	-0.7	-0.1	0.9	0.5	-1.3	-1.2	-1.0
Total sessions with >9 infusions	1.8	2.2	5.5	-0.3	0.9	-0.6	-1.5	-2.0	0.5	-1.3	1.9	0.2	-1.9	-2.0	-2.3
Short access day 1 total inactive lever presses	1.1	1.5	3.0	1.1	1.5	-1.6	-1.6	-1.1	1.7	-1.6	0.7	1.5	-0.0	-0.3	-0.2
Short access day 10 total inactive lever presses	1.0	2.3	5.3	1.7	1.9	-2.0	-1.8	-1.6	2.3	-1.9	1.3	0.7	0.6	0.5	-0.2
Short access day 1 total infusions	0.8	1.1	2.2	0.1	1.5	-1.5	-1.3	-1.1	1.3	-1.3	0.8	-0.8	-0.1	-0.3	-1.1
Short access day 10 total infusions	1.0	1.2	2.4	0.7	1.3	-0.9	-1.5	-1.6	0.8	-1.4	1.5	0.0	-0.8	-0.8	-1.2
Short access total infusions	1.2	1.5	2.7	0.5	1.5	-1.3	-1.6	-1.6	1.2	-1.5	1.4	-0.1	-0.6	-0.8	-1.4
Short access day 1 locomotion	1.5	1.9	4.0	1.1	2.0	-1.8	-1.9	-1.6	1.5	-1.8	1.3	0.6	-0.4	-0.4	-0.8
Short access day 10 total locomotion	1.8	3.3	6.3	2.5	2.5	-1.6	-2.4	-2.1	1.8	-2.3	2.1	1.3	-0.3	0.0	-0.3
Short access total locomotion	4.2	5.0	9.0	2.0	2.6	-1.8	-3.0	-3.0	1.9	-2.8	2.9	1.4	-1.3	-1.2	-1.7
One hour access (0.3 mA shock)	0.3	0.3	1.0	0.7	-0.6	0.7	0.0	-0.1	-0.5	0.3	0.6	-0.7	-1.0	-0.7	-0.2
Compulsive drug intake	0.3	0.4	0.8	-0.1	-0.6	0.6	0.7	0.8	-0.5	0.7	-0.9	0.6	0.3	0.2	0.8
One hour access (shock baseline)	0.7	1.1	3.0	0.7	0.2	-0.2	-1.1	-1.3	0.2	-0.8	1.7	-0.1	-1.5	-1.3	-1.3
Social response proportion	3.3	3.8	11.3	0.2	1.2	-1.5	-2.1	-2.4	1.4	-2.2	2.2	3.4	-1.2	-1.7	-2.1
Social responses	0.6	0.7	1.9	0.7	1.1	-1.3	-0.9	-0.5	0.9	-1.0	0.7	1.4	0.3	0.2	-0.1
Social time	3.7	5.1	9.6	0.8	2.2	-2.2	-2.8	-2.6	2.4	-3.0	2.4	3.1	-0.7	-1.3	-2.0
Soleus weight	0.5	1.4	2.9	0.1	-0.1	-0.4	-1.0	-1.7	0.4	-0.9	1.5	1.5	-1.4	-1.6	-1.5
Bone: stiffness	0.1	0.1	0.5	0.2	-0.6	0.1	0.3	-0.0	-0.4	0.5	0.1	-0.2	-0.1	0.4	0.7
Tibialis anterior weight	0.6	2.2	4.5	-0.4	0.2	-0.2	-1.3	-2.0	0.2	-1.1	2.0	1.4	-2.0	-2.1	-2.1
Time to tail flick, vehicle, before self-admin	1.5	1.6	2.9	-0.7	-1.3	1.3	1.7	1.6	-1.3	1.7	-1.6	-1.3	0.3	0.2	0.8
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	0.8	0.9	-0.8	-0.5	-0.2	0.8	-0.6	-0.0	-0.2	0.9	1.0	0.5
Time to tail flick, test, before self-admin	0.8	0.8	2.4	-1.4	-1.0	0.6	0.4	0.2	-0.6	0.4	0.0	0.1	-1.2	-1.5	-1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.2	0.0	-0.5	-0.2	-0.3	0.4	-0.3	0.2	-0.3	-0.1	-0.3	-0.5
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.2	1.7	1.7	-1.8	-1.6	-1.1	1.8	-1.7	1.0	0.6	0.6	0.6	0.1
Delta time to tail flick, test, before/after SA	0.8	0.9	1.9	1.3	1.2	-1.4	-1.0	-0.6	1.3	-1.0	0.3	0.0	0.7	0.6	0.4
Tibia length	0.2	0.6	3.2	-0.6	-0.1	0.2	0.7	-0.0	-1.0	0.6	-0.1	1.8	0.5	0.9	0.7
Ambulatory time before self-admin	0.2	0.3	0.8	0.7	0.8	-0.6	-0.4	-0.0	0.7	-0.4	-0.2	-0.9	0.4	0.4	0.4
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	0.3	-0.1	-0.1	-0.1	0.2	-0.1	0.1	-0.1	0.2	0.5	0.4
Bone: tissue strength	0.8	0.8	1.8	-1.1	-1.3	1.1	1.3	0.4	-1.3	1.2	-0.5	-0.0	0.1	0.4	0.4
Total heroin consumption	0.7	0.9	2.4	1.4	1.1	-1.3	-0.9	-0.1	1.5	-0.9	-0.2	-0.7	0.7	0.4	0.4
Bone: trabecular number	2.7	4.4	7.6	2.5	2.8	-2.4	-1.5	-0.4	2.6	-1.8	-0.3	1.5	2.7	2.5	2.2
Bone: trabecular spacing	1.3	1.7	3.6	-1.3	-1.6	1.5	0.8	0.2	-1.6	1.0	0.6	-0.8	-1.9	-1.6	-1.4
Bone: trabecular thickness	1.6	2.0	3.3	1.6	1.8	-1.8	-1.6	-1.8	1.5	-1.7	0.7	1.7	0.7	0.6	0.3
Bone: trabecular tissue density	0.6	0.9	1.6	-0.4	-0.8	0.5	1.3	1.2	-0.7	1.1	-1.3	-0.6	0.9	1.0	1.1
Water consumed over 24 hours	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.4	0.2	0.1	0.1	-0.3	0.3	0.5	0.4	-0.1
Number of responses in last shaping day	2.1	2.4	5.3	1.5	1.5	-1.5	-2.0	-2.3	1.3	-1.9	2.1	1.3	-0.5	-0.4	-1.0