Hub : Genes

Hexd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Hexd 0.1 0.05 2.2e-14 0.11 0.13 0.12 0.11 1.5e-12 2.7e-14 1.5e-13 4.3e-12
2 NAcc gene expression Hexd 0.09 0.09 2.3e-04 0.03 0.03 0.05 0.04 3.7e-04 5.5e-04 1.8e-06 2.7e-05
3 Liver isoform ratio XR_005489654.1 0.03 0.03 5.1e-03 0.01 0.01 0.01 0.01 1.1e-02 5.9e-02 3.1e-02 5.0e-02
4 Liver intron excision ratio chr10_106496048_106497107 0.15 0.09 2.2e-05 0.06 0.02 0.04 0.04 1.0e-06 8.7e-04 2.7e-05 1.3e-05
5 LHb gene expression Hexd 0.58 0.18 2.3e-03 0.04 0.08 0 0.05 4.0e-02 4.9e-03 2.5e-01 2.5e-02
6 Liver mRNA stability Hexd 0.06 0.05 8.5e-04 0.02 0.01 0.02 0.03 4.3e-03 1.3e-02 3.9e-03 3.4e-04
7 Brain gene expression Hexd 0.07 0.05 8.9e-05 0.01 0.03 0.03 0.03 4.6e-02 4.5e-04 6.8e-04 1.5e-03
8 Liver gene expression Hexd 0.04 0.04 4.9e-03 0.03 0.01 0 0.01 8.1e-04 6.0e-02 7.9e-02 1.0e-02
9 Liver intron excision ratio chr10_106494771_106495966 0.13 0.08 2.6e-03 0.02 0.01 0.01 0.01 2.0e-03 1.1e-02 1.5e-02 1.5e-02
10 Liver isoform ratio XR_005489670.1 0.05 0.04 1.5e-03 0.01 0.02 0.02 0.01 1.5e-02 3.7e-03 3.0e-03 8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.10.40.60.1-0.60.1-0.1-0.30.10.40.40.1
Area under the delay curve1.81.92.9-1.50.91.5-1.4-1.41.4-1.5-1.7-1.60.6
BMI with tail0.72.27.00.61.3-1.2-1.9-2.71.9-0.5-1.3-1.30.4
BMI without tail2.75.715.53.9-2.1-0.12.50.3-2.61.82.82.72.3
Body weight0.52.08.52.91.1-2.1-0.8-1.50.71.60.00.10.4
Weight adjusted by age1.01.14.11.3-0.3-2.00.90.8-0.71.50.40.6-0.7
Bone surface0.61.11.80.9-0.6-0.71.21.3-1.30.91.31.3-0.3
Bone volume0.50.81.40.9-0.8-0.71.00.9-1.10.71.21.2-0.2
Breakpoint value in progressive ratio session0.50.62.3-0.7-1.20.3-0.5-0.60.40.2-0.5-0.5-1.5
Number of licking bursts0.20.20.60.6-0.40.10.40.2-0.40.00.40.40.8
Context. condit. distance diff. score0.60.72.91.2-0.50.50.7-0.3-0.8-0.10.80.81.7
Locomotion velocity, session 10.91.02.9-1.7-0.5-0.6-0.9-0.10.9-0.5-1.1-1.1-1.3
Locomotion distance, session 12.63.45.2-1.52.01.3-2.0-2.22.0-2.3-1.9-1.91.1
Locomotion velocity, session 23.13.76.1-2.51.41.8-2.1-1.62.1-2.1-2.2-2.20.0
Locomotion distance, session 21.31.82.8-0.31.31.4-1.5-1.71.3-1.4-1.3-1.21.5
Locomotion velocity, session 32.32.64.1-2.01.61.1-1.9-1.31.9-1.4-1.9-1.9-0.7
Locomotion distance, session 34.54.96.7-2.42.01.9-2.6-2.32.5-2.3-2.5-2.5-0.1
Stereotopy head waving bouts, day 30.40.50.8-0.90.7-0.4-0.9-0.20.8-0.4-0.8-0.8-0.5
Stereotopy head waving duration, day 30.30.30.7-0.50.9-0.1-0.7-0.30.7-0.4-0.7-0.70.0
Locomotion velocity, session 70.40.51.0-1.00.21.0-0.7-0.60.6-1.0-0.6-0.60.0
Locomotion distance, session 72.12.75.8-1.60.82.4-1.4-2.01.4-2.3-1.3-1.41.2
Stereotopy head waving bouts, day 70.10.10.20.40.2-0.3-0.3-0.10.20.1-0.2-0.20.5
Stereotopy head waving duration, day 70.10.10.30.50.5-0.5-0.10.20.00.4-0.00.10.0
Locomotion velocity, session 81.92.36.1-0.42.50.9-1.5-2.11.5-1.5-1.4-1.31.1
Locomotion distance, session 81.42.09.50.90.91.8-0.6-1.90.4-1.3-0.4-0.23.1
Degree of sensitization distance1.71.72.91.3-1.4-0.11.71.0-1.70.81.71.60.7
Degree of sensitization stereotypy0.10.10.30.60.0-0.2-0.2-0.30.20.2-0.2-0.10.4
Conditioned locomotion2.12.47.02.6-0.1-0.91.80.9-1.61.61.81.91.0
Cocaine response after cond. corrected0.20.31.0-0.6-0.0-0.2-0.5-0.30.5-0.1-0.6-0.7-1.0
Cocaine response after cond. not corrected0.60.61.1-1.00.40.4-0.9-0.70.8-0.6-1.0-1.1-0.7
Cocaine response before conditioning1.01.22.5-0.81.21.6-1.0-1.00.9-1.3-1.0-1.01.1
Saline control response1.41.84.22.10.1-0.51.61.2-1.51.71.41.50.1
Bone: connectivity density0.10.20.40.50.30.20.40.0-0.5-0.30.40.50.7
Bone: cortical apparent density1.21.64.1-2.00.61.3-1.1-0.81.2-1.4-1.4-1.5-0.5
Bone: cortical area2.33.58.31.82.3-2.9-2.2-2.12.10.9-1.4-1.2-0.6
Bone: cortical porosity1.01.13.1-0.1-1.4-1.50.11.1-0.21.50.30.3-1.8
Bone: cortical porosity1.01.12.40.3-1.4-1.50.41.2-0.51.50.60.6-1.4
Bone: cortical thickness3.96.311.31.22.6-3.4-3.4-2.93.30.7-2.6-2.3-1.1
Bone: cortical thickness2.42.85.20.41.3-2.0-2.3-2.22.30.0-1.9-1.8-0.3
Bone: cortical tissue density1.11.54.5-2.10.41.3-1.0-0.71.1-1.4-1.3-1.4-0.6
Condit. Reinf. active minus inactive responses1.11.22.91.7-0.7-0.81.20.6-1.21.31.31.30.3
Condit. Reinf. active-inactive response ratio0.20.20.80.90.6-0.40.2-0.0-0.20.60.40.5-0.1
Condit. Reinf. active responses2.73.36.52.5-1.7-1.12.01.2-2.02.02.02.10.7
Condit. Reinf. inactive responses1.72.03.51.5-1.9-0.71.71.2-1.71.31.51.50.5
Incentive salience index mean1.01.22.61.6-0.8-0.41.30.7-1.31.11.31.40.5
Condit. Reinf. lever presses0.20.30.60.2-0.60.70.60.0-0.5-0.20.40.40.8
Condit. Reinf. active minus inactive responses0.40.51.81.21.2-1.3-0.1-0.40.20.6-0.00.10.1
Condit. Reinf. active-inactive response ratio1.11.24.41.6-0.1-2.10.70.6-0.61.50.70.8-0.4
Condit. Reinf. active responses0.20.31.60.71.3-0.7-0.2-0.70.30.1-0.1-0.10.3
Condit. Reinf. inactive responses0.91.02.6-0.81.60.9-1.0-1.21.1-1.0-0.9-0.90.3
Condit. Reinf. lever presses0.20.21.10.70.00.50.1-0.2-0.20.00.30.31.0
Condit. Reinf. lever reinforcers received0.20.20.90.71.0-0.4-0.1-0.70.20.1-0.00.00.5
Conditioned reinforcement - actives0.20.21.20.30.10.60.1-0.1-0.1-0.30.20.11.1
Conditioned reinforcement - inactives0.40.52.30.7-1.50.60.60.1-0.60.80.40.50.2
Conditioned locomotion0.20.20.50.2-0.30.70.50.3-0.50.00.70.40.6
Patch foraging indifference point 0 sec0.10.10.60.10.20.00.40.3-0.40.30.40.3-0.8
Patch foraging indifference point AUC0.50.62.60.5-1.6-0.20.80.5-0.90.30.70.70.6
Delay disc. indifference point, 0s delay1.11.23.4-0.41.8-0.7-1.2-1.01.2-0.6-1.3-1.30.3
Delay disc. indifference point, 16s delay2.42.45.9-1.11.02.4-1.1-1.71.1-1.9-1.1-1.12.1
Delay disc. indifference point, 2s delay0.50.51.1-0.80.20.2-0.8-0.70.8-0.6-1.0-1.10.0
Delay disc. indifference point, 24s delay2.82.76.6-2.60.31.9-1.7-1.21.8-1.8-1.8-1.8-0.1
Delay disc. indifference point, 4s delay1.11.23.0-0.81.70.4-1.2-1.01.2-0.8-1.4-1.3-0.2
Delay disc. indifference point, 8s delay1.41.43.0-1.31.10.7-1.4-1.01.3-0.9-1.7-1.6-0.2
Indifference point function ln k2.94.010.9-1.33.30.6-2.4-1.82.3-1.7-2.2-2.2-0.2
Indifference point function log k2.94.010.9-1.33.30.6-2.4-1.82.3-1.7-2.2-2.2-0.2
Patch foraging total patch changes 0 sec0.00.10.30.20.40.10.20.1-0.20.10.20.1-0.6
Patch foraging total patch changes 12 sec0.70.93.90.2-2.0-0.51.10.7-1.00.60.90.8-0.6
Patch foraging total patch changes 18 sec0.20.20.50.1-0.50.70.7-0.3-0.6-0.30.30.20.4
Patch foraging total patch changes 24 sec0.30.40.90.7-0.7-0.20.90.3-0.90.60.60.6-0.3
Patch foraging total patch changes 6 sec0.60.91.90.7-1.4-0.71.11.1-1.11.00.90.9-0.4
Patch foraging time to switch 0 sec0.10.10.5-0.7-0.10.20.20.3-0.1-0.4-0.1-0.1-0.3
Patch foraging water rate 0 sec0.30.42.21.5-0.30.40.4-0.5-0.50.80.50.50.4
Patch foraging water rate 12 sec1.01.55.00.20.90.0-1.5-2.21.3-0.8-1.4-1.30.9
Patch foraging water rate 18 sec0.60.82.10.71.30.4-0.8-1.40.6-0.5-0.6-0.51.2
Patch foraging water rate 24 sec0.60.83.01.31.10.6-0.4-1.70.1-0.1-0.2-0.11.3
Patch foraging water rate 6 sec2.33.38.7-0.41.50.8-2.3-2.92.1-1.3-2.1-2.10.8
Seeking ratio, delayed vs. immediate footshock0.70.82.01.4-0.4-1.30.80.5-0.61.01.10.8-0.6
Distance traveled before self-admin0.70.72.00.5-0.7-0.10.81.2-0.71.40.50.7-1.1
Distance traveled after self-admin2.42.75.01.1-2.21.32.21.6-2.11.01.41.71.4
Extensor digitorum longus weight0.10.41.40.91.0-0.1-0.1-0.70.1-0.60.30.31.2
Bone: elastic displacement0.30.41.20.90.2-0.70.40.6-0.31.10.40.4-0.3
Bone: elastic work2.33.013.52.00.0-3.70.10.9-0.12.60.50.6-2.0
Bone: endosteal estimation0.20.50.90.5-0.20.70.90.1-0.9-0.11.00.90.8
Bone: endosteal perimeter0.81.62.51.20.1-1.01.51.3-1.51.31.61.5-0.9
Epididymis fat weight0.20.41.61.3-0.20.10.5-0.3-0.40.50.50.51.2
Delta time in closed arm before/after self-admin0.40.43.10.01.7-0.6-0.2-0.40.0-0.5-0.2-0.1-0.3
Delta time in open arm before/after self-admin0.40.31.7-0.2-1.31.00.4-0.1-0.3-0.10.40.3-0.0
Diff in mean of infusions in LGA sessions0.30.41.8-0.90.40.3-0.10.10.1-0.4-0.6-0.5-1.3
Delay discount exponential model param2.12.23.41.7-0.7-1.61.51.4-1.51.61.91.8-0.3
Extinction: sum of active levers before priming1.41.43.6-1.9-0.3-0.6-1.2-1.01.2-1.0-1.4-1.5-0.9
Active lever presses in extinction session 62.92.84.5-2.0-0.21.0-1.9-1.92.1-1.0-2.1-2.1-1.3
Bone: final force1.72.85.41.91.7-2.3-1.9-2.21.90.9-1.2-1.0-0.2
Bone: final moment1.62.67.62.11.5-2.8-1.7-1.81.61.3-0.9-0.7-0.6
Food consumed during 24 hour testing period0.70.81.40.9-0.1-0.61.01.2-1.10.81.11.20.4
Glucose1.82.78.1-2.8-0.2-0.6-1.6-0.31.7-0.4-2.0-1.9-2.3
Heart weight0.30.52.70.7-0.6-1.6-0.5-0.40.40.5-0.2-0.20.6
Delay discount hyperbolic model param2.12.23.31.7-0.9-1.41.61.5-1.61.61.81.8-0.3
Intermittent access intake day 1-15 change1.61.63.00.9-1.70.61.61.3-1.71.20.81.3-0.6
Intermittent access intake escalation1.81.84.00.9-2.01.21.61.2-1.71.11.11.5-0.0
Intermittent access intake escalation 22.82.712.00.8-3.50.11.61.4-1.61.81.11.4-1.3
Intermitt. access day 1 inactive lever presses0.30.30.80.6-0.3-0.10.50.4-0.50.90.50.4-0.7
Intermitt. access day 15 inactive lever presses0.50.51.11.0-0.20.80.70.1-0.70.50.90.90.8
Intermitt. access escalation Index1.51.42.61.30.5-0.31.60.8-1.60.51.51.50.9
Intermittent access day 1 total infusions0.20.20.70.9-0.3-0.60.00.3-0.10.40.70.50.6
Intermittent access day 15 total infusions1.01.12.11.1-1.50.31.10.8-1.20.81.21.30.3
Intermittent access terminal intake (last 3 days)1.71.93.21.2-1.8-0.11.51.4-1.61.31.61.7-0.4
Intermittent access total infusions0.40.41.11.0-0.30.10.60.6-0.70.60.70.90.4
Intermittent access day 1 locomotion0.40.41.30.31.20.7-0.5-1.00.4-0.30.2-0.20.4
Intermittent access day 15 total locomotion0.30.30.70.6-0.00.40.50.5-0.60.70.80.7-0.4
Intermittent access total locomotion0.10.20.80.40.60.9-0.2-0.40.10.10.30.0-0.0
Intermittent access standard deviation1.11.12.2-1.5-0.40.9-1.2-0.61.2-0.3-1.4-1.3-1.1
Left kidney weight1.02.74.9-0.41.9-1.7-2.2-1.82.2-0.6-1.8-1.7-0.9
Right kidney weight1.64.48.1-0.62.8-0.8-2.8-2.52.9-1.2-2.5-2.30.1
Cocaine induced anxiety2.52.910.00.7-2.6-2.40.50.8-0.42.10.40.3-3.2
Post-drug Anxiety0.60.74.5-0.3-0.8-0.7-0.4-0.30.50.6-0.5-0.6-2.1
Baseline Anxiety5.25.612.8-2.23.62.6-2.0-2.12.0-2.9-2.1-2.01.6
Tail length3.911.722.34.7-2.8-0.24.12.4-4.23.34.04.11.9
Length with tail0.41.35.32.30.4-1.40.40.6-0.52.00.70.9-0.1
Length without tail3.57.815.0-2.22.9-1.6-3.8-2.13.9-1.0-3.4-3.2-2.2
Times rat made contact with spout6.87.915.41.5-3.0-1.93.23.9-3.32.83.23.1-0.9
Lifetime Intake0.10.20.40.5-0.30.00.30.4-0.40.30.50.60.1
Liver weight, left0.30.51.1-0.80.1-0.5-0.80.00.90.1-1.0-1.0-0.6
Liver weight, right0.20.31.51.2-0.2-0.80.20.0-0.11.00.30.30.1
Locomotor activity0.40.71.5-1.20.21.1-0.9-0.70.9-1.0-0.7-0.8-0.1
Locomotor testing distance0.71.22.6-1.21.60.9-1.1-0.91.1-1.4-1.1-1.10.2
Locomotor testing rearing0.20.31.4-0.6-0.81.20.40.1-0.5-0.50.40.30.3
Locomotion in novel chamber0.70.95.7-0.42.4-0.2-0.8-0.60.8-0.7-0.8-0.60.1
Locomotion in novel chamber post-restriction2.02.44.22.0-0.7-1.41.61.5-1.41.81.82.0-0.5
Fecal boli incidents, locomotor time 10.30.31.1-0.4-1.00.70.0-0.1-0.1-0.60.30.21.0
Change in fecal boli incidents, locomotor task1.11.15.1-1.6-0.7-0.0-0.70.20.7-0.4-0.8-0.9-2.2
Time >=10cm from walls, locomotor time 10.80.91.71.20.40.71.30.2-1.30.31.11.10.6
Bouts of movement, locomotor time 10.40.51.4-1.20.4-0.3-0.8-0.30.9-0.9-0.2-0.70.3
Total resting periods, locomotor time 10.50.51.8-1.30.3-0.1-0.9-0.21.0-0.9-0.2-0.80.1
Rest time, locomotor task time 10.20.31.6-0.3-1.3-0.30.00.70.10.20.50.00.0
Distance moved, locomotor task time 10.30.41.30.10.81.1-0.2-1.00.0-0.2-0.8-0.3-0.3
Vertical activity count, locomotor time 10.30.30.70.70.80.70.2-0.8-0.3-0.1-0.1-0.00.6
Time >=10cm from walls, locomotor time 20.30.31.00.51.0-0.8-0.5-0.30.5-0.1-0.4-0.40.5
Bouts of movement, locomotor time 21.71.95.1-1.12.30.6-1.3-1.31.4-1.4-1.6-1.40.5
Total resting periods, locomotor time 21.41.54.9-0.72.20.7-1.0-1.11.1-1.3-1.2-1.10.9
Rest time, locomotor task time 20.50.61.40.2-1.0-0.21.01.2-0.70.31.00.90.3
Distance moved, locomotor task time 21.21.32.6-0.31.30.4-1.4-1.51.3-0.7-1.6-1.50.4
Vertical activity count, locomotor time 21.51.74.3-0.01.20.9-1.2-2.11.0-1.0-1.3-1.41.6
Light reinforcement 10.81.42.91.70.1-1.61.40.8-1.40.81.31.20.2
Light reinforcement 20.81.02.51.6-0.8-1.21.20.3-1.10.91.01.00.3
Bone: marrow area0.20.40.80.4-0.20.80.90.0-0.8-0.20.90.80.7
Bone: maximum diameter0.50.92.61.01.6-1.4-0.8-1.00.80.5-0.4-0.3-0.6
Bone: maximum force1.62.86.72.21.7-2.6-1.8-2.11.71.0-1.0-0.80.1
Bone: maximum moment1.52.69.12.41.4-3.0-1.4-1.71.41.4-0.7-0.5-0.3
Mean time between licks in bursts1.01.42.7-1.60.51.3-0.9-1.51.0-1.6-1.3-1.3-0.1
Mean num. licks in bursts1.51.84.30.5-0.9-1.11.42.1-1.41.51.41.4-1.0
Cd content in liver2.32.53.7-1.50.91.2-1.9-1.91.8-1.7-1.8-1.80.8
Co content in liver0.10.10.2-0.50.00.4-0.0-0.1-0.1-0.40.0-0.0-0.2
Cu content in liver0.20.30.7-0.1-0.7-0.60.10.7-0.10.8-0.00.0-0.9
Fe content in liver0.50.62.9-1.10.41.7-0.3-0.50.3-1.0-0.3-0.4-0.1
K content in liver2.02.03.21.7-1.80.21.60.8-1.80.91.71.71.0
Mg content in liver1.41.54.50.9-1.51.51.1-0.1-1.2-0.31.01.02.1
Mn content in liver0.10.10.50.4-0.7-0.1-0.2-0.20.10.3-0.1-0.10.6
Na content in liver0.00.00.1-0.1-0.10.30.20.3-0.30.00.20.2-0.2
Rb content in liver0.50.62.61.4-0.50.20.4-0.3-0.50.40.50.61.6
Se content in liver1.51.83.51.0-1.40.11.91.4-1.81.01.61.60.2
Sr content in liver0.80.73.7-0.5-0.2-0.90.11.3-0.20.80.20.3-1.9
Zn content in liver0.00.00.2-0.2-0.10.4-0.1-0.10.0-0.2-0.1-0.00.0
Bone: minimum diameter0.81.55.51.80.8-2.30.20.2-0.31.50.70.8-1.2
Time in familiar zone, hab. session 10.10.10.4-0.2-0.6-0.6-0.3-0.20.30.2-0.4-0.3-0.3
Time in novel zone, hab. session 10.00.00.10.20.30.20.20.1-0.1-0.10.10.10.1
Total zone transitions, hab. session 10.60.81.2-0.50.60.4-1.0-1.11.0-0.9-1.1-1.10.8
Total locomotion distance, hab. session 10.20.21.50.40.10.0-0.3-0.50.3-0.3-0.4-0.31.2
Locomotion velocity, hab. session 10.20.21.80.5-0.00.2-0.1-0.40.1-0.3-0.2-0.21.3
Time in familiar zone, hab. session 20.10.10.3-0.4-0.60.4-0.1-0.3-0.0-0.5-0.1-0.20.1
Time in novel zone, hab. session 20.40.41.6-0.21.30.1-0.7-0.70.8-0.3-0.7-0.60.1
Total zone transitions, hab. session 20.81.04.00.30.90.5-0.7-1.40.6-1.1-0.6-0.62.0
Total locomotion distance, hab. session 20.50.74.21.30.30.10.3-0.6-0.3-0.40.20.32.1
Locomotion velocity, hab. session 20.50.74.11.50.3-0.00.4-0.5-0.4-0.20.30.42.0
Novel to familiar place preference ratio1.11.24.11.2-0.1-2.00.41.0-0.41.70.50.6-1.2
Novelty place preference1.21.24.51.10.1-2.10.31.0-0.31.70.40.6-1.3
Time in novel zone, NPP test0.90.93.71.00.1-1.90.30.8-0.31.50.40.5-1.1
Total zone transitions, NPP test1.01.54.70.11.31.7-0.4-1.40.4-1.5-0.5-0.52.2
Total locomotion distance, NPP test0.91.26.80.90.51.40.2-1.0-0.1-0.9-0.0-0.02.6
Locomotion velocity, NPP test0.50.74.41.00.51.00.2-0.6-0.2-0.60.10.12.1
Intraocular pressure0.60.81.71.30.00.90.90.5-0.90.80.91.01.2
Delta distance traveled before/after self-admin0.60.71.70.0-1.21.30.9-0.0-0.8-0.60.30.51.3
Delta ambulatory time before/after self-admin0.60.71.9-0.3-1.21.40.60.0-0.7-0.90.20.31.1
Parametrial fat weight1.22.34.61.8-2.1-1.21.31.4-1.51.71.61.60.3
Pavlov. Cond. lever latency1.41.73.5-0.61.01.7-1.1-1.91.0-1.7-1.0-1.01.5
Pavlov. Cond. magazine entry latency2.02.64.91.1-1.1-1.91.41.8-1.42.21.41.4-1.9
Pavlov. Cond. change in total contacts0.50.52.0-0.2-0.7-1.00.30.9-0.20.90.20.1-1.4
Pavlov. Cond. index score2.43.05.21.5-1.2-2.11.62.0-1.62.31.71.7-1.4
Pavlov. Cond. latency score2.43.05.11.3-1.4-2.01.72.2-1.62.21.71.6-1.5
Pavlov. Cond. lever contacts0.81.01.90.6-0.8-1.11.01.4-0.91.20.90.9-0.9
Pavlov. Cond. magazine entry number2.22.75.3-0.81.52.1-1.3-2.01.2-2.3-1.2-1.32.0
Pavlov. Cond. intertrial magazine entries0.40.51.31.0-0.90.00.7-0.0-0.70.10.70.71.1
Pavlov. Cond. lever-magazine prob. diff.2.12.64.91.5-1.0-2.01.41.8-1.42.21.51.5-1.4
Pavlov. Cond. response bias1.61.93.90.8-1.1-1.91.11.6-1.02.01.11.1-1.8
Pavlov. Cond. lever latency0.60.81.5-1.20.5-0.0-0.9-0.41.0-0.5-1.1-1.1-1.1
Pavlov. Cond. magazine entry latency1.01.14.2-1.0-0.22.1-0.4-1.00.4-1.5-0.5-0.61.4
Pavlov. Cond. change in total contacts0.20.20.8-0.10.60.9-0.1-0.50.0-0.60.00.00.8
Pavlov. Cond. index score0.30.41.60.1-0.51.20.3-0.1-0.4-0.50.30.31.2
Pavlov. Cond. latency score0.30.41.80.2-0.41.10.4-0.2-0.5-0.50.40.41.4
Pavlov. Cond. lever contacts1.01.32.41.5-0.50.21.30.6-1.40.71.41.51.4
Pavlov. Cond. magazine entry number0.91.14.80.8-0.0-2.20.40.9-0.41.50.50.6-1.4
Pavlov. Cond. intertrial magazine entries0.70.92.81.70.2-1.20.70.4-0.81.20.81.00.2
Pavlov. Cond. lever-magazine prob. diff.0.30.41.7-0.1-0.51.30.3-0.2-0.4-0.60.30.31.2
Pavlov. Cond. response bias0.30.41.60.6-0.30.80.4-0.1-0.5-0.10.60.61.3
Time in closed arm before self-admin0.20.30.8-0.6-0.50.6-0.8-0.10.90.1-0.3-0.4-0.3
Time in closed arm after self-admin0.70.71.9-1.20.70.3-1.1-0.11.0-0.2-0.6-0.7-1.4
Time in open arm before self-admin0.40.52.60.21.3-1.6-0.20.00.1-0.4-0.4-0.10.4
Time in open arm after self-admin0.10.10.4-0.2-0.3-0.4-0.0-0.60.0-0.6-0.3-0.20.1
Bone: periosteal estimation0.40.82.21.51.2-1.5-0.6-1.10.60.6-0.2-0.1-0.1
Bone: periosteal perimeter1.01.78.11.40.9-2.8-0.30.10.31.60.10.2-1.8
Bone: post-yield work0.40.52.00.01.40.3-0.7-1.20.7-0.7-0.5-0.50.4
Progressive ratio test 1 active lever presses0.90.92.11.2-0.20.11.10.9-1.20.91.51.3-0.2
Progressive ratio test 1 breakpoint1.41.52.91.5-0.4-0.31.41.2-1.51.21.71.5-0.3
Progressive ratio test 1 inactive lever presses0.50.51.91.4-0.60.00.60.1-0.60.90.80.90.2
Progressive ratio test 2 active lever presses0.70.71.50.9-0.8-0.20.90.7-1.00.81.21.1-0.3
Progressive ratio test 2 breakpoint0.70.71.51.0-0.4-0.01.00.6-1.10.71.21.20.1
Progressive ratio test 2 inactive lever presses0.20.20.80.4-0.1-0.50.2-0.0-0.30.50.30.3-0.9
Incentive Sensitization - Responses1.31.32.11.0-1.3-0.61.41.2-1.41.01.31.4-0.0
Incentive Sensitization - Breakpoint1.21.31.90.9-1.3-0.61.31.2-1.41.01.31.4-0.2
Sum of active levers in priming session hrs 5-61.01.06.00.0-2.5-0.70.40.3-0.40.90.60.5-1.3
Progressive ratio0.40.50.9-0.9-0.50.9-0.7-0.70.8-0.8-0.2-0.60.5
Food seeking constrained by brief footshock0.10.20.8-0.4-0.3-0.10.20.9-0.00.30.40.3-0.5
Seeking ratio, punishment vs. effort0.40.40.80.70.5-0.70.80.9-0.80.60.40.7-0.3
Retroperitoneal fat weight2.68.414.73.8-2.7-1.13.22.7-3.23.23.33.31.1
Reaction time number correct1.21.77.00.81.31.5-0.2-1.90.1-1.4-0.10.02.7
Reaction time mean minus median0.40.62.8-0.6-1.70.40.50.9-0.50.30.50.4-0.7
Reaction time mean minus median AUC0.10.10.5-0.2-0.70.30.30.4-0.20.20.40.4-0.0
Reaction time num false alarms0.00.00.1-0.40.0-0.3-0.00.2-0.1-0.20.10.0-0.2
Reaction time num false alarms AUC0.10.10.4-0.60.30.2-0.3-0.10.2-0.6-0.3-0.30.2
Reaction time trials correct on left1.21.77.00.81.31.5-0.2-1.90.1-1.4-0.10.02.7
Reaction time trials on left1.31.87.30.81.31.6-0.2-2.00.1-1.4-0.10.02.7
Reaction time mean0.50.71.90.6-1.4-0.20.90.6-0.80.61.11.10.2
Reaction time mean AUC0.40.51.10.6-0.90.20.70.4-0.70.31.01.00.8
Median of all reaction times0.20.30.70.6-0.8-0.20.50.1-0.40.30.80.80.4
Reaction time omissions0.50.72.20.3-1.50.90.90.3-0.90.00.90.90.4
Reaction time false alarm rate0.30.41.6-0.9-0.6-0.6-0.01.0-0.10.2-0.0-0.1-1.2
Reaction time premature initiation rate0.20.30.9-1.00.10.4-0.5-0.30.4-0.8-0.4-0.5-0.2
Reaction time premature initiations0.60.81.9-0.40.91.3-0.5-1.20.3-1.4-0.4-0.41.3
Std. dev. reaction times0.20.31.3-0.5-1.10.80.40.4-0.3-0.20.40.40.3
Reaction time trials completed1.31.87.30.81.31.6-0.2-2.00.1-1.4-0.10.02.7
Reaction time trials AUC1.21.77.00.81.31.4-0.2-1.90.1-1.4-0.00.12.6
Run reversals in cocaine runway, females0.20.20.6-0.2-0.30.60.1-0.1-0.1-0.50.60.40.8
Run reversals in cocaine runway, males2.12.04.50.9-2.1-1.21.41.8-1.41.80.81.0-1.1
Latency to leave start box in cocaine runway0.40.41.6-0.0-1.11.00.30.0-0.3-0.40.00.11.3
Latency to leave start box in cocaine runway, F0.70.85.00.2-0.71.30.2-0.2-0.2-0.8-0.3-0.02.2
Latency to leave start box in cocaine runway, M0.30.30.80.2-0.9-0.00.60.5-0.60.50.60.5-0.3
Std. dev. time between licks in bursts0.91.14.21.01.01.40.1-1.40.0-0.80.00.12.1
Total sessions with >9 infusions0.40.40.7-0.50.90.7-0.8-0.80.7-0.8-0.5-0.50.2
Short access day 1 total inactive lever presses0.40.51.90.10.80.3-0.3-1.00.3-0.8-0.3-0.31.4
Short access day 10 total inactive lever presses0.60.62.21.5-0.4-0.90.60.0-0.51.40.30.5-0.4
Short access day 1 total infusions1.31.42.6-1.61.30.2-1.3-1.11.3-1.4-1.2-1.1-0.7
Short access day 10 total infusions0.80.91.70.7-1.3-0.20.91.0-1.00.91.21.2-0.7
Short access total infusions0.00.00.10.0-0.2-0.20.00.2-0.10.10.20.3-0.3
Short access day 1 locomotion0.80.92.3-1.10.7-0.8-1.0-0.71.0-0.6-0.7-0.9-1.5
Short access day 10 total locomotion0.50.52.3-0.80.60.1-0.8-0.30.8-0.1-0.2-0.6-1.5
Short access total locomotion0.70.81.5-0.91.2-0.2-1.1-0.71.0-0.6-0.4-0.9-1.2
One hour access (0.3 mA shock)1.72.03.41.7-1.3-0.41.81.1-1.81.31.51.60.7
Compulsive drug intake0.30.32.20.70.40.50.20.0-0.20.30.20.31.5
One hour access (shock baseline)0.60.71.21.0-0.6-0.71.10.9-1.10.51.11.00.4
Social response proportion2.42.65.3-1.11.91.3-1.8-2.31.8-1.5-1.6-1.5-0.1
Social responses2.93.812.2-0.93.50.6-2.3-2.02.2-1.5-2.0-2.0-0.5
Social time1.41.83.6-0.61.90.3-1.6-1.81.6-1.1-1.4-1.40.2
Soleus weight0.92.75.42.3-0.3-1.71.61.4-1.71.82.02.10.1
Bone: stiffness2.23.58.70.31.7-0.7-2.6-2.92.6-0.7-2.1-2.00.8
Tibialis anterior weight0.20.71.40.9-0.1-0.51.20.8-0.90.31.21.10.6
Time to tail flick, vehicle, before self-admin0.30.31.00.6-0.20.40.70.5-0.70.40.20.81.0
Time to tail flick, vehicle, after self-admin2.02.13.4-1.41.80.2-1.6-1.41.6-1.7-1.7-1.80.4
Time to tail flick, test, before self-admin0.60.63.80.2-1.31.90.20.2-0.20.30.1-0.00.5
Time to tail flick, test, after self-admin1.01.02.4-1.10.41.5-1.0-1.00.9-0.9-1.3-1.10.0
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.30.2-0.1-0.4-0.50.3-0.8-0.1-0.50.6
Delta time to tail flick, test, before/after SA1.91.72.4-1.40.6-1.3-1.4-1.31.4-0.9-1.6-1.5-1.4
Tibia length2.16.027.33.80.8-5.2-0.00.50.23.80.60.9-1.4
Ambulatory time before self-admin0.70.72.50.8-0.6-0.40.61.0-0.71.60.50.8-1.0
Ambulatory time after self-admin1.01.13.10.6-1.80.91.50.9-1.40.70.51.00.6
Bone: tissue strength0.70.72.10.91.40.1-0.9-1.40.8-0.2-0.4-0.30.7
Total heroin consumption1.82.14.1-1.3-0.6-0.3-1.7-1.51.8-0.4-2.0-1.9-1.3
Bone: trabecular number0.20.30.60.4-0.6-0.80.50.5-0.70.30.70.7-0.1
Bone: trabecular spacing1.11.44.90.61.22.0-0.1-1.40.3-1.0-0.2-0.22.2
Bone: trabecular thickness1.41.75.50.1-1.2-2.40.61.1-0.61.40.60.5-2.3
Bone: trabecular tissue density0.71.02.8-1.20.11.7-0.9-0.70.9-1.0-0.9-1.00.5
Water consumed over 24 hours0.40.52.0-0.1-0.3-1.00.41.4-0.60.70.50.5-0.7
Number of responses in last shaping day0.50.51.30.31.1-0.6-0.7-1.20.7-0.1-0.8-0.6-0.2