Hub : Genes

Hexd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Hexd 0.15 0.08 1.5e-03 0.02 0.04 0.03 0.03 7.3e-03 3.1e-04 3.2e-03 2.7e-03
2 Adipose alternative polyA NM_001142562.2 0.03 0.02 6.7e-04 0 0.03 0.01 0.01 2.3e-01 8.3e-04 2.0e-02 5.1e-02
3 NAcc isoform ratio XR_010055103.1 0.02 0.01 2.6e-03 0.01 0.01 0 0.01 2.0e-02 4.0e-03 1.1e-01 1.3e-02
4 Adipose alternative polyA XM_063268231.1 0.03 0.02 1.8e-03 0 0.02 0.01 0.01 3.6e-01 2.7e-03 2.3e-02 4.8e-02
5 Adipose isoform ratio XM_039084985.2 0.06 0.04 1.3e-04 0.02 0.03 0.02 0.04 2.1e-03 2.0e-04 8.6e-04 7.3e-05
6 Adipose gene expression Hexd 0.11 0.05 2.1e-15 0.12 0.14 0.13 0.1 4.1e-13 3.6e-15 1.0e-14 3.1e-11
7 IC alternative polyA XM_063268231.1 0.12 0.07 3.4e-04 0.02 0.07 0.03 0.04 3.3e-02 5.5e-04 1.4e-02 6.5e-03
8 IC alternative polyA NM_001142562.2 0.12 0.07 4.2e-04 0.03 0.07 0.03 0.04 2.4e-02 6.7e-04 1.6e-02 6.2e-03
9 Adipose alternative polyA XM_063268231.1 0.06 0.04 3.9e-07 0.02 0.05 0.04 0.03 4.7e-03 1.4e-06 3.9e-05 1.5e-04
10 Adipose alternative polyA NM_001142562.2 0.06 0.04 2.8e-07 0.04 0.06 0.04 0.03 5.6e-05 1.0e-06 3.7e-05 1.3e-04
11 LHb gene expression Hexd 0.55 0.17 4.8e-04 0.15 0.12 0.14 0.15 2.3e-04 9.3e-04 3.1e-04 1.8e-04
12 Brain gene expression Hexd 0.07 0.05 2.8e-04 0.04 0.03 0.02 0.04 5.6e-05 9.9e-04 7.6e-03 1.2e-04
13 Liver intron excision ratio chr10_106994340_106995399 0.15 0.1 3.8e-05 0.04 0.02 0.03 0.04 8.8e-05 1.1e-03 1.5e-04 4.8e-05
14 Liver mRNA stability Hexd 0.07 0.06 6.4e-04 0.02 0.01 0.03 0.02 2.1e-03 1.3e-02 1.2e-04 2.1e-03
15 Liver isoform ratio NM_001142562.2 0.03 0.03 4.2e-03 0.01 0.02 0.01 0.02 1.1e-02 5.1e-03 1.0e-02 3.9e-03
16 Liver alternative polyA XM_063268231.1 0.08 0.06 3.2e-03 0.03 0.02 0.03 0.03 3.1e-04 1.5e-03 4.8e-04 2.0e-04
17 NAcc gene expression Hexd 0.09 0.06 6.0e-06 0.04 0.04 0.04 0.04 1.3e-06 3.0e-06 3.7e-07 3.1e-07
18 PL alternative polyA NM_001142562.2 0.26 0.11 5.4e-10 0.12 0.1 0.1 0.11 6.6e-13 7.0e-11 1.5e-11 5.0e-12
19 PL alternative polyA XM_063268231.1 0.26 0.11 4.8e-10 0.12 0.1 0.11 0.11 8.1e-13 5.5e-11 8.9e-12 4.7e-12
20 Liver intron excision ratio chr10_106993063_106994258 0.14 0.08 2.3e-03 0.02 0.01 0.02 0.01 2.6e-03 1.5e-02 5.3e-03 2.0e-02
21 Liver alternative polyA NM_001142562.2 0.07 0.06 4.1e-03 0.03 0.02 0.02 0.03 3.8e-04 2.3e-03 1.2e-03 5.7e-04
22 Liver gene expression Hexd 0.04 0.03 3.0e-03 0.02 0.01 0.01 0.02 1.1e-03 2.3e-02 1.4e-02 4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.30.50.80.50.90.7-0.8-0.80.80.9-0.9-0.80.80.70.6-0.6-0.4-0.60.7-0.4-0.70.7-0.7-0.7-0.7
Area under the delay curve1.51.73.6-0.5-1.1-1.31.10.9-1.3-1.11.11.2-1.2-1.5-1.31.51.61.9-1.3-1.71.2-1.21.21.41.4
BMI with tail0.51.96.6-2.60.40.3-0.42.00.30.2-0.2-0.10.1-2.1-2.11.81.40.5-1.7-0.21.6-1.61.61.71.7
BMI without tail1.13.37.80.52.82.7-2.8-0.92.72.6-2.6-2.72.70.50.7-0.7-1.2-1.20.91.7-1.11.1-1.1-0.9-0.9
Body weight0.41.75.2-1.51.82.3-1.91.12.01.4-1.4-1.91.9-1.0-0.50.6-0.0-0.6-0.81.60.5-0.50.50.70.7
Weight adjusted by age0.60.82.1-0.31.11.4-1.2-0.41.41.1-1.1-1.31.30.71.1-0.8-0.6-1.30.40.5-0.40.4-0.4-0.5-0.5
Bone surface0.71.22.11.20.70.8-0.8-1.30.90.8-0.8-0.90.91.51.5-1.4-1.1-1.11.20.1-1.41.4-1.4-1.2-1.2
Bone volume0.71.21.81.10.90.9-0.9-1.20.90.9-0.9-0.90.91.31.4-1.3-1.1-1.11.20.2-1.31.3-1.3-1.1-1.1
Breakpoint value in progressive ratio session0.30.31.70.2-1.0-0.10.81.0-0.5-1.31.30.4-0.4-0.4-0.30.10.0-0.1-0.30.30.3-0.30.30.20.2
Number of licking bursts0.20.30.70.50.80.5-0.7-0.80.60.8-0.8-0.60.60.50.4-0.3-0.40.00.50.3-0.40.4-0.4-0.4-0.4
Context. condit. distance diff. score1.21.53.11.71.71.2-1.6-1.61.31.8-1.8-1.41.40.90.9-0.7-0.9-0.01.00.5-0.90.9-0.9-0.9-0.9
Locomotion velocity, session 12.32.54.2-1.7-2.1-1.82.01.7-1.8-2.02.01.9-1.9-1.3-1.01.21.30.7-1.5-0.51.4-1.41.41.41.4
Locomotion distance, session 12.83.65.6-1.8-0.9-1.81.21.4-1.5-0.90.91.5-1.5-2.2-2.22.32.42.2-2.2-1.72.3-2.32.32.32.3
Locomotion velocity, session 23.84.45.8-1.4-2.2-2.42.31.8-2.4-2.12.12.3-2.3-2.1-2.02.12.22.2-2.0-1.72.1-2.12.12.12.1
Locomotion distance, session 21.01.42.7-1.30.0-0.50.10.7-0.40.0-0.00.4-0.4-1.5-1.41.61.61.6-1.5-1.01.5-1.51.51.61.6
Locomotion velocity, session 33.03.45.1-1.5-2.0-1.92.01.7-2.0-2.02.02.0-2.0-1.7-1.51.72.01.6-1.8-2.31.7-1.71.71.81.8
Locomotion distance, session 35.25.67.4-1.6-2.1-2.42.22.1-2.4-2.22.22.3-2.3-2.6-2.32.52.72.6-2.5-2.42.5-2.52.52.52.5
Stereotopy head waving bouts, day 30.70.82.3-1.5-1.1-1.11.11.1-1.0-1.01.01.1-1.1-0.7-0.80.60.70.2-0.8-0.60.7-0.70.70.70.7
Stereotopy head waving duration, day 30.50.61.8-1.4-0.7-0.90.80.9-0.8-0.70.70.8-0.9-0.6-0.80.70.70.3-0.8-0.40.7-0.70.70.70.7
Locomotion velocity, session 70.20.30.70.5-0.5-0.80.6-0.2-0.7-0.50.40.6-0.6-0.4-0.20.50.50.8-0.3-0.60.4-0.40.40.40.4
Locomotion distance, session 71.11.34.40.5-0.7-1.40.90.2-1.4-0.60.61.2-1.2-1.3-1.01.41.42.1-1.0-1.21.2-1.21.21.21.2
Stereotopy head waving bouts, day 70.10.10.3-0.50.40.4-0.40.10.40.3-0.3-0.40.40.3-0.1-0.3-0.5-0.50.30.6-0.30.3-0.3-0.3-0.3
Stereotopy head waving duration, day 70.10.10.3-0.30.50.5-0.5-0.10.50.5-0.5-0.50.50.4-0.0-0.3-0.4-0.40.30.1-0.30.3-0.3-0.3-0.3
Locomotion velocity, session 81.31.65.8-1.00.1-0.50.10.6-0.40.1-0.10.4-0.4-1.6-1.51.71.91.6-1.5-2.41.5-1.51.51.61.6
Locomotion distance, session 80.71.13.40.51.80.8-1.6-1.01.01.8-1.8-1.11.1-0.6-0.40.90.61.5-0.4-0.40.5-0.50.50.60.6
Degree of sensitization distance2.52.64.02.01.61.4-1.6-1.91.51.6-1.6-1.51.51.61.7-1.6-1.6-1.11.71.1-1.71.7-1.7-1.7-1.7
Degree of sensitization stereotypy0.20.20.4-0.20.60.6-0.6-0.10.60.6-0.5-0.60.60.2-0.1-0.2-0.4-0.20.20.6-0.20.2-0.2-0.2-0.2
Conditioned locomotion3.84.37.11.52.62.6-2.7-2.02.62.6-2.6-2.62.61.71.7-1.7-1.7-1.51.81.0-1.81.8-1.8-1.7-1.7
Cocaine response after cond. corrected0.50.61.0-0.6-0.9-0.50.81.0-0.7-1.01.00.7-0.7-0.8-0.70.80.70.5-0.8-0.40.9-0.90.90.80.8
Cocaine response after cond. not corrected1.21.42.0-0.7-1.2-1.01.11.2-1.1-1.21.21.1-1.1-1.3-1.21.31.21.2-1.3-0.41.4-1.41.41.31.3
Cocaine response before conditioning0.60.72.4-0.1-0.3-0.80.40.1-0.7-0.20.20.6-0.6-0.9-0.91.11.01.5-0.9-0.21.1-1.11.11.11.1
Saline control response2.23.04.71.62.02.2-2.1-1.82.12.0-2.0-2.12.11.61.6-1.5-1.3-1.31.50.3-1.61.6-1.6-1.5-1.5
Bone: connectivity density0.40.71.51.00.90.5-0.8-1.20.61.0-1.0-0.70.71.00.8-0.8-0.4-0.30.9-0.8-0.90.9-0.9-0.8-0.8
Bone: cortical apparent density1.72.34.2-0.8-1.8-2.11.91.1-2.0-1.71.71.9-1.9-1.2-1.31.31.41.6-1.2-1.31.3-1.31.31.21.2
Bone: cortical area1.52.313.3-3.61.11.5-1.22.31.40.8-0.8-1.11.1-1.8-1.81.41.1-0.4-1.5-1.01.3-1.31.31.31.3
Bone: cortical porosity0.50.62.4-1.1-1.0-0.10.70.9-0.3-1.01.00.4-0.40.30.2-0.6-0.9-1.30.21.5-0.20.2-0.2-0.5-0.5
Bone: cortical porosity0.50.62.5-0.8-0.50.30.30.50.2-0.50.5-0.00.00.60.5-0.9-1.2-1.60.61.5-0.60.6-0.6-0.8-0.8
Bone: cortical thickness2.64.428.2-5.30.30.9-0.43.60.80.00.1-0.40.3-2.7-2.82.21.8-0.1-2.4-1.02.2-2.22.22.12.1
Bone: cortical thickness1.61.910.0-3.2-0.10.20.02.30.1-0.20.30.1-0.1-1.9-1.91.61.20.2-1.6-0.41.6-1.61.61.41.4
Bone: cortical tissue density1.62.24.4-0.6-1.9-2.11.91.0-2.1-1.81.82.0-2.0-1.0-1.11.21.31.5-1.1-1.11.2-1.21.21.11.1
Condit. Reinf. active minus inactive responses1.11.32.70.21.51.6-1.5-0.61.61.4-1.4-1.61.60.90.8-1.0-0.9-1.20.80.3-0.90.9-0.9-0.8-0.8
Condit. Reinf. active-inactive response ratio0.30.31.9-0.60.70.8-0.70.20.80.6-0.6-0.70.70.1-0.1-0.10.2-0.50.0-1.4-0.10.1-0.1-0.1-0.1
Condit. Reinf. active responses2.93.66.20.92.32.5-2.4-1.42.42.2-2.2-2.42.41.61.6-1.6-1.8-1.71.51.6-1.61.6-1.6-1.6-1.6
Condit. Reinf. inactive responses1.72.04.91.31.41.5-1.5-1.41.51.3-1.3-1.51.51.31.5-1.3-1.6-1.01.32.2-1.31.3-1.3-1.3-1.3
Incentive salience index mean1.11.42.50.61.51.6-1.5-0.91.61.4-1.4-1.61.51.00.9-1.0-1.0-1.11.00.5-1.01.0-1.0-1.0-1.0
Condit. Reinf. lever presses0.20.20.80.90.60.3-0.5-0.70.30.6-0.6-0.40.40.20.3-0.2-0.40.20.40.8-0.20.2-0.2-0.3-0.3
Condit. Reinf. active minus inactive responses0.40.52.1-1.30.70.7-0.70.60.70.6-0.6-0.60.6-0.7-0.80.60.80.0-0.7-1.50.5-0.50.50.60.6
Condit. Reinf. active-inactive response ratio0.50.51.6-1.10.91.3-1.00.31.20.8-0.8-1.11.10.10.2-0.5-0.3-1.20.1-0.0-0.30.3-0.3-0.2-0.2
Condit. Reinf. active responses0.30.53.1-0.80.40.3-0.40.50.30.3-0.3-0.30.3-0.7-0.90.70.90.5-0.7-1.80.6-0.60.60.70.7
Condit. Reinf. inactive responses0.70.93.8-0.1-0.5-0.80.60.5-0.9-0.60.60.7-0.7-0.8-1.11.11.31.3-0.9-2.00.9-0.90.91.01.0
Condit. Reinf. lever presses0.20.30.80.40.90.7-0.8-0.50.70.8-0.8-0.70.70.40.1-0.2-0.20.00.3-0.2-0.30.3-0.3-0.2-0.2
Condit. Reinf. lever reinforcers received0.20.31.8-0.50.60.4-0.60.20.40.5-0.5-0.40.4-0.5-0.70.50.70.4-0.5-1.30.4-0.40.40.50.5
Conditioned reinforcement - actives0.10.10.8-0.1-0.1-0.30.20.1-0.3-0.10.10.3-0.3-0.4-0.50.50.20.9-0.20.60.3-0.30.30.30.3
Conditioned reinforcement - inactives0.10.10.70.60.20.4-0.3-0.10.30.0-0.0-0.30.30.30.3-0.2-0.30.10.00.80.0-0.00.0-0.0-0.0
Conditioned locomotion0.00.10.20.00.2-0.0-0.2-0.30.00.2-0.2-0.10.10.20.2-0.2-0.00.40.2-0.4-0.40.4-0.4-0.1-0.1
Patch foraging indifference point 0 sec0.10.20.60.70.30.4-0.3-0.80.30.2-0.3-0.40.40.50.5-0.5-0.2-0.20.4-0.5-0.40.4-0.4-0.4-0.4
Patch foraging indifference point AUC0.30.41.20.60.60.5-0.6-0.80.60.7-0.7-0.60.60.60.6-0.5-0.7-0.40.51.1-0.50.5-0.5-0.5-0.5
Delay disc. indifference point, 0s delay0.50.61.3-1.1-0.2-0.30.20.9-0.3-0.20.20.3-0.3-1.1-0.91.01.00.6-1.0-0.80.9-0.90.91.01.0
Delay disc. indifference point, 16s delay0.80.94.30.2-0.3-0.90.5-0.1-0.9-0.40.30.7-0.7-1.2-1.01.31.22.1-0.9-1.10.9-0.90.91.11.1
Delay disc. indifference point, 2s delay0.50.50.7-0.5-0.8-0.80.80.8-0.8-0.90.90.8-0.8-0.7-0.60.70.60.8-0.6-0.40.8-0.80.80.50.5
Delay disc. indifference point, 24s delay4.14.66.9-1.3-2.6-2.62.61.8-2.6-2.52.52.6-2.6-2.0-1.71.92.12.0-1.9-2.11.7-1.71.71.91.9
Delay disc. indifference point, 4s delay0.80.84.5-0.7-0.5-0.50.50.7-0.6-0.50.50.5-0.5-1.0-0.91.01.31.1-0.9-2.10.8-0.80.80.90.9
Delay disc. indifference point, 8s delay1.51.82.4-0.9-1.3-1.11.31.3-1.2-1.41.31.2-1.2-1.5-1.41.61.51.4-1.4-1.51.3-1.31.31.51.5
Indifference point function ln k1.42.55.3-1.4-1.0-1.31.11.3-1.3-0.90.91.3-1.3-1.7-1.91.82.11.6-1.7-2.31.7-1.71.71.81.8
Indifference point function log k1.42.55.3-1.4-1.0-1.31.11.3-1.3-0.90.91.3-1.3-1.7-1.91.82.11.6-1.7-2.31.7-1.71.71.81.8
Patch foraging total patch changes 0 sec0.10.10.60.60.40.4-0.4-0.70.30.3-0.3-0.40.40.40.3-0.3-0.0-0.00.2-0.8-0.30.3-0.3-0.2-0.2
Patch foraging total patch changes 12 sec0.40.62.10.90.20.5-0.3-0.70.40.2-0.2-0.40.40.90.9-0.9-1.1-0.60.81.5-0.80.8-0.8-0.8-0.8
Patch foraging total patch changes 18 sec0.10.10.60.60.50.2-0.4-0.80.20.5-0.5-0.30.30.20.3-0.20.10.30.2-0.7-0.20.2-0.2-0.2-0.2
Patch foraging total patch changes 24 sec0.20.40.70.40.70.9-0.8-0.70.80.7-0.7-0.80.80.60.7-0.7-0.3-0.50.4-0.3-0.50.5-0.5-0.5-0.5
Patch foraging total patch changes 6 sec0.30.51.30.30.60.8-0.6-0.60.70.6-0.6-0.70.70.80.8-0.9-0.9-0.80.71.1-0.70.7-0.7-0.7-0.7
Patch foraging time to switch 0 sec0.10.20.60.2-0.6-0.80.70.1-0.7-0.60.60.7-0.7-0.1-0.00.1-0.10.20.00.30.0-0.00.0-0.0-0.0
Patch foraging water rate 0 sec0.40.93.00.91.41.7-1.5-0.81.51.2-1.2-1.61.60.30.6-0.4-0.2-0.10.3-0.2-0.30.3-0.3-0.3-0.3
Patch foraging water rate 12 sec0.40.81.6-0.90.50.3-0.50.60.30.3-0.3-0.30.3-1.3-1.01.11.30.9-1.2-0.81.2-1.21.21.21.2
Patch foraging water rate 18 sec0.30.51.1-0.51.00.7-0.9-0.00.70.9-0.9-0.70.7-0.4-0.40.60.80.5-0.5-1.10.5-0.50.50.60.6
Patch foraging water rate 24 sec0.60.92.60.11.61.4-1.6-0.51.31.4-1.4-1.41.4-0.10.10.20.40.4-0.1-1.50.0-0.00.00.10.1
Patch foraging water rate 6 sec1.42.14.0-1.4-0.2-0.30.31.4-0.4-0.40.50.4-0.4-1.9-1.81.81.91.5-2.0-1.31.9-1.91.92.02.0
Seeking ratio, delayed vs. immediate footshock0.60.81.80.31.21.3-1.3-0.61.31.2-1.2-1.31.30.30.6-0.5-0.4-0.90.5-0.0-0.70.7-0.7-0.5-0.5
Distance traveled before self-admin0.10.10.90.20.10.7-0.20.20.50.0-0.0-0.50.50.50.5-0.3-0.2-0.20.2-1.0-0.10.1-0.1-0.3-0.3
Distance traveled after self-admin1.82.26.82.61.31.4-1.3-2.21.31.3-1.3-1.41.41.72.1-1.5-1.5-0.41.41.4-1.11.1-1.1-1.3-1.3
Extensor digitorum longus weight0.10.51.8-0.11.30.7-1.2-0.60.91.4-1.4-0.90.9-0.2-0.20.1-0.20.20.10.6-0.00.0-0.00.00.0
Bone: elastic displacement0.30.41.2-0.80.60.8-0.70.20.80.6-0.6-0.70.70.40.2-0.6-0.6-1.10.50.6-0.50.5-0.5-0.6-0.6
Bone: elastic work1.11.46.4-2.30.81.8-1.11.21.70.7-0.6-1.41.30.40.2-0.9-1.0-2.50.40.8-0.70.7-0.7-0.7-0.7
Bone: endosteal estimation0.20.52.51.60.70.4-0.7-1.10.40.7-0.7-0.60.60.50.7-0.5-0.50.10.60.5-0.70.7-0.7-0.4-0.4
Bone: endosteal perimeter0.61.31.81.31.01.2-1.0-1.11.21.0-1.0-1.21.21.11.4-1.2-0.9-1.21.0-0.7-1.31.3-1.3-1.0-1.0
Epididymis fat weight0.41.23.30.71.71.8-1.7-0.81.61.6-1.5-1.71.70.10.2-0.1-0.6-0.00.21.8-0.20.2-0.2-0.1-0.1
Delta time in closed arm before/after self-admin0.20.20.60.80.60.2-0.5-0.80.20.6-0.6-0.30.30.0-0.10.20.10.60.3-0.30.1-0.10.1-0.1-0.1
Delta time in open arm before/after self-admin0.20.20.30.3-0.5-0.40.5-0.0-0.5-0.50.50.4-0.40.40.2-0.5-0.4-0.20.30.5-0.20.2-0.2-0.4-0.4
Diff in mean of infusions in LGA sessions0.30.31.71.3-0.20.30.1-0.40.1-0.20.2-0.10.10.60.8-0.7-0.7-0.70.70.4-0.50.5-0.5-0.6-0.6
Delay discount exponential model param2.22.54.10.71.51.6-1.5-1.21.71.5-1.5-1.61.61.71.5-1.7-1.8-2.01.51.9-1.51.5-1.5-1.6-1.6
Extinction: sum of active levers before priming1.71.82.9-1.7-1.6-1.51.61.6-1.5-1.61.61.6-1.6-1.3-1.01.11.10.3-1.40.11.3-1.31.31.31.3
Active lever presses in extinction session 65.35.39.0-2.2-2.7-1.92.53.0-2.2-2.92.92.3-2.3-2.4-2.02.02.01.2-2.4-1.12.2-2.22.22.32.3
Bone: final force1.11.88.3-2.91.51.9-1.61.71.81.3-1.2-1.61.6-1.3-1.30.80.4-0.6-0.9-0.10.7-0.70.70.70.7
Bone: final moment1.11.78.3-2.91.52.1-1.71.62.01.3-1.2-1.71.7-1.0-0.90.40.1-1.0-0.60.10.4-0.40.40.40.4
Food consumed during 24 hour testing period0.91.21.81.10.91.0-0.9-1.21.01.0-1.0-1.01.01.21.1-1.2-1.3-1.11.30.5-1.31.3-1.3-1.3-1.3
Glucose7.912.424.5-3.5-4.9-4.04.74.2-4.2-4.95.04.4-4.4-2.5-2.72.42.51.2-3.1-1.22.8-2.82.82.72.7
Heart weight0.40.64.4-2.10.10.4-0.21.50.40.1-0.0-0.20.2-0.8-0.70.5-0.1-0.5-0.61.60.5-0.50.50.50.5
Delay discount hyperbolic model param1.92.13.30.71.41.5-1.5-1.21.61.5-1.5-1.51.51.51.4-1.6-1.7-1.81.41.7-1.31.3-1.3-1.4-1.4
Intermittent access intake day 1-15 change0.51.15.72.40.11.0-0.3-1.20.60.0-0.0-0.70.71.51.6-1.4-1.1-0.81.10.7-0.90.9-0.9-1.0-1.0
Intermittent access intake escalation0.40.84.72.20.10.9-0.3-1.10.50.0-0.0-0.70.71.31.4-1.2-0.8-0.60.80.0-0.70.7-0.7-0.8-0.8
Intermittent access intake escalation 21.11.23.82.0-0.01.0-0.2-0.90.7-0.20.2-0.70.71.71.7-1.7-1.3-1.31.10.9-1.11.1-1.1-1.1-1.1
Intermitt. access day 1 inactive lever presses0.72.75.22.32.02.2-2.0-1.92.01.8-1.8-2.12.11.51.6-1.3-1.3-0.51.21.2-1.21.2-1.2-1.1-1.1
Intermitt. access day 15 inactive lever presses0.71.52.11.21.41.2-1.4-1.41.31.4-1.4-1.31.31.41.1-1.1-1.0-0.61.3-0.1-1.11.1-1.1-1.3-1.3
Intermitt. access escalation Index1.01.53.51.91.21.1-1.2-1.71.01.2-1.2-1.21.21.11.2-1.0-0.9-0.51.3-0.6-1.41.4-1.4-1.2-1.2
Intermittent access day 1 total infusions0.10.11.0-0.90.20.1-0.20.50.20.3-0.2-0.10.1-0.3-0.50.4-0.10.2-0.31.00.2-0.20.20.30.3
Intermittent access day 15 total infusions0.30.40.90.90.60.8-0.6-0.70.70.5-0.5-0.70.70.80.7-0.7-0.7-0.40.60.4-0.50.5-0.5-0.6-0.6
Intermittent access terminal intake (last 3 days)0.71.02.11.40.61.0-0.7-1.00.90.6-0.6-0.90.91.31.2-1.2-1.1-0.81.10.7-0.90.9-0.9-1.1-1.1
Intermittent access total infusions0.10.10.30.40.40.6-0.5-0.40.50.4-0.4-0.50.50.30.1-0.1-0.20.10.20.3-0.00.0-0.0-0.1-0.1
Intermittent access day 1 locomotion0.30.41.3-0.5-0.2-0.30.30.5-0.4-0.30.30.3-0.3-0.8-0.80.80.81.1-0.7-1.10.4-0.40.40.70.7
Intermittent access day 15 total locomotion0.10.20.40.40.30.6-0.4-0.30.50.3-0.3-0.50.50.50.5-0.5-0.4-0.20.4-0.1-0.60.6-0.6-0.5-0.5
Intermittent access total locomotion0.10.10.50.10.00.2-0.10.10.0-0.10.1-0.10.1-0.2-0.30.30.30.6-0.2-0.7-0.00.0-0.00.30.3
Intermittent access standard deviation0.81.63.7-0.4-1.8-1.11.61.4-1.4-1.91.91.4-1.4-1.1-0.90.90.90.8-1.0-0.11.3-1.31.31.01.0
Left kidney weight0.52.37.0-2.6-0.8-0.70.82.2-0.7-0.91.00.8-0.8-2.1-1.91.91.50.8-1.9-0.41.8-1.81.81.81.8
Right kidney weight0.73.49.9-3.1-1.0-0.91.02.5-0.9-1.11.11.1-1.1-2.4-2.22.21.91.1-2.3-0.92.1-2.12.12.22.2
Cocaine induced anxiety1.11.56.1-1.6-1.5-0.31.22.5-0.7-1.71.70.8-0.8-1.1-1.30.81.0-0.3-1.4-0.81.0-1.01.01.11.1
Post-drug Anxiety2.72.97.5-1.8-2.0-1.01.82.7-1.4-2.22.21.5-1.5-1.7-1.81.41.60.4-1.8-1.41.5-1.51.51.61.6
Baseline Anxiety0.20.20.80.3-0.6-0.90.7-0.2-0.8-0.50.50.7-0.7-0.2-0.10.20.20.5-0.0-0.30.1-0.10.10.10.1
Tail length2.710.415.82.93.34.0-3.5-2.93.73.2-3.2-3.83.83.03.2-3.0-3.3-2.62.83.4-3.03.0-3.0-2.8-2.8
Length with tail0.20.73.50.10.81.9-1.10.21.40.5-0.5-1.41.40.30.6-0.4-0.7-0.90.21.4-0.30.3-0.3-0.3-0.3
Length without tail1.23.810.0-3.1-1.8-0.81.63.2-1.1-2.02.01.3-1.3-2.2-2.01.91.80.6-2.3-0.62.2-2.22.22.02.0
Times rat made contact with spout5.56.311.32.20.91.5-1.1-2.31.51.1-1.1-1.41.53.43.3-3.3-3.2-3.12.92.4-3.23.2-3.2-3.0-3.0
Lifetime Intake0.00.00.20.2-0.00.1-0.0-0.1-0.0-0.00.0-0.00.0-0.1-0.20.20.10.5-0.20.20.3-0.30.30.30.3
Liver weight, left1.42.43.1-1.0-1.6-1.51.61.6-1.6-1.61.61.6-1.6-1.5-1.71.71.31.5-1.60.41.7-1.71.71.61.6
Liver weight, right0.91.73.10.91.71.8-1.7-1.01.71.6-1.6-1.71.71.00.8-0.9-1.1-0.81.10.7-1.01.0-1.0-1.1-1.1
Locomotor activity0.40.51.2-0.2-1.0-1.11.00.4-1.1-1.01.01.0-1.0-0.4-0.60.60.50.8-0.6-0.10.5-0.50.50.60.6
Locomotor testing distance0.71.32.3-0.5-1.0-1.51.20.3-1.4-1.00.91.3-1.3-0.9-1.21.31.21.4-1.0-1.21.1-1.11.11.11.1
Locomotor testing rearing0.10.21.81.3-0.2-0.50.3-1.0-0.4-0.10.10.3-0.30.60.4-0.2-0.10.50.3-0.2-0.30.3-0.3-0.3-0.3
Locomotion in novel chamber0.40.61.8-0.4-0.1-0.40.20.2-0.3-0.00.00.3-0.3-0.7-0.50.81.20.7-1.0-1.31.0-1.01.01.11.1
Locomotion in novel chamber post-restriction3.04.96.82.32.12.6-2.2-2.22.42.0-2.0-2.42.42.32.3-2.2-2.2-2.12.21.2-2.32.3-2.3-2.1-2.1
Fecal boli incidents, locomotor time 10.10.11.6-0.1-0.0-0.50.1-0.3-0.30.1-0.10.3-0.3-0.1-0.00.1-0.30.30.11.3-0.30.3-0.30.00.0
Change in fecal boli incidents, locomotor task1.31.23.8-0.0-1.9-1.31.81.0-1.5-1.91.91.5-1.5-0.5-0.70.30.40.2-0.5-0.20.7-0.70.70.40.4
Time >=10cm from walls, locomotor time 11.71.83.61.91.61.4-1.6-1.81.31.6-1.6-1.51.51.31.3-1.1-0.6-0.31.3-1.2-1.31.3-1.3-1.1-1.1
Bouts of movement, locomotor time 10.80.92.0-1.3-1.2-1.41.20.9-1.2-1.01.01.3-1.3-1.0-0.80.90.60.5-0.7-0.10.4-0.40.40.70.7
Total resting periods, locomotor time 11.01.12.4-1.3-1.3-1.61.41.0-1.4-1.21.21.5-1.5-1.0-0.81.00.70.6-0.8-0.30.3-0.30.30.70.7
Rest time, locomotor task time 10.20.31.1-0.3-0.8-0.70.80.4-0.6-0.70.70.7-0.70.10.1-0.3-0.5-0.40.21.1-0.40.4-0.4-0.3-0.3
Distance moved, locomotor task time 10.20.31.51.20.20.5-0.3-0.30.2-0.00.0-0.40.4-0.2-0.10.30.50.7-0.3-1.10.6-0.60.60.40.4
Vertical activity count, locomotor time 10.20.41.11.00.91.0-0.9-0.60.80.8-0.8-0.90.90.40.2-0.2-0.10.20.3-0.5-0.30.3-0.3-0.2-0.2
Time >=10cm from walls, locomotor time 20.20.21.9-1.40.40.2-0.40.80.30.5-0.5-0.20.2-0.5-0.60.50.5-0.0-0.4-0.40.1-0.10.10.40.4
Bouts of movement, locomotor time 20.91.42.7-0.4-0.8-1.00.90.8-1.1-0.90.91.0-1.0-1.4-1.31.51.21.5-1.3-0.61.7-1.71.71.41.4
Total resting periods, locomotor time 20.40.71.6-0.1-0.3-0.60.40.2-0.6-0.30.30.6-0.6-1.1-0.91.20.81.3-0.9-0.31.2-1.21.21.01.0
Rest time, locomotor task time 20.50.61.61.20.30.2-0.2-1.10.30.4-0.4-0.30.30.81.0-0.9-1.1-0.61.01.3-0.90.9-0.9-0.9-0.9
Distance moved, locomotor task time 20.81.01.9-1.1-0.4-0.30.41.4-0.4-0.50.50.4-0.4-1.2-1.31.21.31.0-1.2-1.01.3-1.31.31.21.2
Vertical activity count, locomotor time 20.50.71.7-1.10.1-0.2-0.01.1-0.2-0.00.00.2-0.2-1.0-1.31.21.01.1-1.1-0.50.8-0.80.81.11.1
Light reinforcement 11.23.04.51.62.11.7-2.0-2.01.92.1-2.1-1.91.91.51.5-1.4-1.6-1.41.71.4-1.61.6-1.6-1.6-1.6
Light reinforcement 21.21.82.80.91.71.6-1.7-1.21.61.6-1.6-1.61.61.01.0-1.0-1.3-1.31.11.6-1.11.1-1.1-1.1-1.1
Bone: marrow area0.20.42.31.50.70.4-0.6-1.00.40.7-0.7-0.50.50.40.6-0.4-0.50.20.50.4-0.60.6-0.6-0.4-0.4
Bone: maximum diameter0.30.62.6-1.60.60.8-0.61.10.80.5-0.4-0.60.6-0.9-0.80.60.6-0.3-0.7-1.30.5-0.50.50.60.6
Bone: maximum force1.11.97.6-2.81.72.1-1.81.62.01.5-1.4-1.81.7-1.3-1.20.80.4-0.6-0.9-0.20.7-0.70.70.80.8
Bone: maximum moment1.01.87.6-2.81.72.2-1.91.52.11.4-1.4-1.91.8-0.9-0.90.40.0-1.1-0.60.00.3-0.30.30.40.4
Mean time between licks in bursts0.61.62.3-0.4-1.2-1.51.30.9-1.5-1.21.21.4-1.4-1.2-1.21.41.31.5-1.2-0.81.3-1.31.31.21.2
Mean num. licks in bursts0.81.23.10.80.00.6-0.2-0.70.50.1-0.1-0.40.51.61.5-1.7-1.4-1.81.21.0-1.51.5-1.5-1.3-1.3
Cd content in liver0.10.10.80.80.4-0.1-0.3-0.4-0.00.4-0.4-0.10.1-0.3-0.20.40.10.9-0.10.50.2-0.20.20.20.2
Co content in liver0.40.51.01.00.10.1-0.1-0.80.10.1-0.1-0.20.21.00.9-0.9-0.8-0.70.90.2-1.01.0-1.0-0.9-0.9
Cu content in liver0.50.61.60.50.20.7-0.3-0.40.60.2-0.2-0.50.51.01.0-1.1-1.0-1.30.90.4-1.01.0-1.0-1.0-1.0
Fe content in liver0.10.20.50.4-0.3-0.60.4-0.1-0.6-0.30.30.5-0.5-0.4-0.40.30.20.7-0.1-0.10.3-0.30.30.20.2
K content in liver2.62.56.12.51.81.5-1.8-2.31.51.8-1.8-1.71.71.51.5-1.3-1.3-0.61.60.5-1.41.4-1.4-1.4-1.4
Mg content in liver2.22.37.32.71.81.2-1.7-2.31.31.8-1.8-1.51.51.31.3-1.1-1.1-0.11.50.7-1.31.3-1.3-1.3-1.3
Mn content in liver0.10.10.3-0.50.20.1-0.20.30.10.2-0.2-0.10.1-0.3-0.30.30.30.3-0.40.10.3-0.30.30.40.4
Na content in liver0.10.11.01.00.30.0-0.2-0.50.00.2-0.2-0.10.10.10.00.00.20.40.2-0.9-0.10.1-0.1-0.1-0.1
Rb content in liver2.12.44.51.12.11.8-2.1-1.41.92.1-2.1-2.02.01.21.1-1.2-1.1-1.01.40.1-1.41.4-1.4-1.3-1.3
Se content in liver1.31.62.61.60.90.9-0.9-1.50.90.9-0.9-1.01.01.41.5-1.5-1.4-1.01.60.6-1.51.5-1.5-1.5-1.5
Sr content in liver0.40.41.1-0.9-1.0-0.60.90.8-0.7-1.01.00.8-0.8-0.2-0.10.10.3-0.3-0.4-0.30.3-0.30.30.20.2
Zn content in liver2.73.04.32.11.61.7-1.7-1.91.71.6-1.6-1.71.71.61.8-1.7-2.0-1.31.81.9-1.81.8-1.8-1.7-1.7
Bone: minimum diameter0.61.13.1-0.61.41.8-1.5-0.11.71.3-1.2-1.61.60.50.7-0.7-0.6-1.40.5-0.0-0.80.8-0.8-0.6-0.6
Time in familiar zone, hab. session 10.10.10.5-0.6-0.4-0.20.40.7-0.2-0.50.50.3-0.3-0.4-0.30.20.1-0.1-0.40.20.3-0.30.30.30.3
Time in novel zone, hab. session 10.10.10.20.30.30.1-0.3-0.50.20.4-0.4-0.20.20.30.2-0.2-0.2-0.10.30.0-0.20.2-0.2-0.2-0.2
Total zone transitions, hab. session 10.50.81.5-1.2-0.4-0.70.40.9-0.6-0.40.40.6-0.6-1.0-1.11.01.00.8-1.1-0.01.1-1.11.11.11.1
Total locomotion distance, hab. session 10.20.21.1-0.90.60.1-0.50.20.30.6-0.6-0.20.2-0.5-0.50.40.20.3-0.41.00.4-0.40.40.40.4
Locomotion velocity, hab. session 10.20.21.3-0.80.60.2-0.50.10.30.6-0.6-0.30.3-0.4-0.30.30.10.3-0.31.10.4-0.40.40.40.4
Time in familiar zone, hab. session 20.10.10.30.3-0.3-0.40.30.1-0.4-0.30.30.4-0.4-0.4-0.20.30.10.5-0.20.50.2-0.20.20.20.2
Time in novel zone, hab. session 20.30.31.5-0.8-0.1-0.20.10.5-0.2-0.10.10.2-0.2-0.5-0.60.60.80.3-0.6-1.20.6-0.60.60.60.6
Total zone transitions, hab. session 20.30.41.1-0.41.00.2-0.8-0.30.41.1-1.1-0.40.4-0.6-0.60.70.60.7-0.5-0.10.6-0.60.60.70.7
Total locomotion distance, hab. session 20.70.93.30.11.81.0-1.6-0.91.21.8-1.8-1.31.2-0.10.10.0-0.20.20.20.9-0.00.0-0.0-0.0-0.0
Locomotion velocity, hab. session 20.81.13.80.11.91.2-1.8-0.91.41.9-1.9-1.41.40.00.2-0.1-0.30.00.21.0-0.10.1-0.1-0.1-0.1
Novel to familiar place preference ratio0.60.62.6-0.70.51.2-0.70.21.10.4-0.4-0.90.90.60.6-0.8-0.8-1.60.50.2-0.80.8-0.8-0.7-0.7
Novelty place preference0.50.62.7-0.70.41.1-0.60.21.00.4-0.3-0.80.80.60.6-0.8-0.8-1.60.5-0.0-0.80.8-0.8-0.7-0.7
Time in novel zone, NPP test0.40.42.0-0.70.41.0-0.60.20.90.4-0.4-0.80.80.50.5-0.6-0.6-1.40.4-0.0-0.60.6-0.6-0.6-0.6
Total zone transitions, NPP test0.30.51.70.31.00.0-0.8-0.70.21.0-1.1-0.40.3-0.6-0.60.80.81.3-0.4-0.60.6-0.60.60.60.6
Total locomotion distance, NPP test0.60.82.70.61.60.7-1.4-1.10.91.6-1.7-1.01.0-0.2-0.10.30.10.90.00.80.1-0.10.10.20.2
Locomotion velocity, NPP test0.50.72.50.51.60.8-1.4-1.01.01.6-1.6-1.11.1-0.10.10.1-0.10.60.20.8-0.00.0-0.00.00.0
Intraocular pressure1.01.42.31.31.51.5-1.5-1.41.41.4-1.4-1.51.51.01.2-1.0-0.9-0.60.90.5-1.01.0-1.0-0.8-0.8
Delta distance traveled before/after self-admin0.40.42.21.50.30.0-0.3-1.40.00.4-0.4-0.20.20.60.9-0.6-0.60.10.61.3-0.40.4-0.4-0.5-0.5
Delta ambulatory time before/after self-admin0.40.53.01.70.3-0.3-0.1-1.6-0.20.4-0.40.0-0.00.70.8-0.6-0.60.20.71.4-0.40.4-0.4-0.6-0.6
Parametrial fat weight1.02.37.81.31.51.4-1.5-1.21.51.5-1.5-1.51.51.51.2-1.3-1.9-1.21.52.8-1.41.4-1.4-1.4-1.4
Pavlov. Cond. lever latency0.30.42.50.50.2-0.5-0.0-0.3-0.40.2-0.20.2-0.2-0.7-0.60.90.91.6-0.6-0.90.7-0.70.70.70.7
Pavlov. Cond. magazine entry latency0.40.52.0-0.10.21.1-0.40.00.80.1-0.0-0.70.70.80.8-0.9-0.8-1.40.50.2-0.60.6-0.6-0.7-0.7
Pavlov. Cond. change in total contacts0.30.31.0-0.8-0.8-0.20.70.8-0.3-0.90.90.5-0.50.1-0.1-0.1-0.3-0.5-0.21.00.1-0.10.10.10.1
Pavlov. Cond. index score1.01.23.40.10.71.5-0.9-0.41.30.6-0.6-1.21.21.21.2-1.3-1.4-1.90.91.1-1.11.1-1.1-1.1-1.1
Pavlov. Cond. latency score0.91.13.60.00.41.2-0.6-0.31.10.4-0.4-0.90.91.31.1-1.3-1.4-1.91.01.2-1.11.1-1.1-1.1-1.1
Pavlov. Cond. lever contacts0.30.31.2-0.10.10.6-0.2-0.10.50.1-0.1-0.40.40.70.6-0.7-0.9-1.10.51.1-0.60.6-0.6-0.6-0.6
Pavlov. Cond. magazine entry number0.40.52.90.50.2-0.90.1-0.3-0.70.3-0.30.5-0.5-0.9-0.80.91.01.7-0.4-0.80.7-0.70.70.70.7
Pavlov. Cond. intertrial magazine entries0.60.81.60.91.30.9-1.2-0.91.01.3-1.3-1.11.10.50.5-0.4-0.7-0.10.71.2-0.60.6-0.6-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.70.92.7-0.10.61.4-0.8-0.31.20.5-0.5-1.11.11.01.0-1.1-1.1-1.60.70.8-0.90.9-0.9-0.9-0.9
Pavlov. Cond. response bias0.30.32.0-0.5-0.20.7-0.00.40.5-0.30.3-0.40.30.60.6-0.7-0.8-1.40.30.7-0.50.5-0.5-0.5-0.5
Pavlov. Cond. lever latency1.42.03.0-1.3-1.7-1.41.71.6-1.5-1.71.71.6-1.6-1.4-1.21.21.20.9-1.3-0.51.3-1.31.31.31.3
Pavlov. Cond. magazine entry latency0.30.41.60.6-0.3-0.90.5-0.3-0.8-0.30.30.7-0.7-0.5-0.60.60.41.3-0.40.40.6-0.60.60.60.6
Pavlov. Cond. change in total contacts0.10.10.50.60.3-0.0-0.2-0.60.00.3-0.3-0.10.10.20.00.10.20.40.0-0.7-0.00.0-0.00.00.0
Pavlov. Cond. index score0.10.10.60.80.40.1-0.4-0.70.10.4-0.4-0.20.20.40.2-0.2-0.30.30.30.5-0.20.2-0.2-0.2-0.2
Pavlov. Cond. latency score0.20.20.90.90.60.2-0.5-0.90.30.6-0.6-0.40.40.50.4-0.3-0.40.20.40.5-0.30.3-0.3-0.3-0.3
Pavlov. Cond. lever contacts1.31.92.61.41.61.3-1.6-1.61.41.6-1.6-1.51.51.51.2-1.2-1.2-0.81.40.4-1.41.4-1.4-1.3-1.3
Pavlov. Cond. magazine entry number0.30.31.6-0.70.30.7-0.40.30.70.3-0.2-0.60.60.40.6-0.6-0.5-1.30.4-0.2-0.60.6-0.6-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.91.32.60.31.51.6-1.6-0.71.61.5-1.4-1.61.60.90.9-1.0-0.7-1.01.0-0.3-1.01.0-1.0-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.60.80.2-0.1-0.1-0.6-0.10.2-0.2-0.00.00.30.1-0.1-0.20.40.20.5-0.10.1-0.1-0.1-0.1
Pavlov. Cond. response bias0.20.20.70.80.70.4-0.6-0.70.40.7-0.7-0.50.50.50.2-0.2-0.30.10.40.2-0.30.3-0.3-0.3-0.3
Time in closed arm before self-admin0.71.02.8-1.7-1.1-0.81.01.5-0.9-1.01.01.0-1.0-1.0-1.10.80.90.2-1.0-1.20.5-0.50.50.90.9
Time in closed arm after self-admin0.60.71.3-0.3-1.1-0.81.10.8-1.0-1.11.11.0-1.0-0.9-1.00.70.70.8-0.6-0.90.4-0.40.40.60.6
Time in open arm before self-admin0.40.51.80.21.20.6-1.1-1.00.91.3-1.3-0.80.80.40.5-0.0-0.2-0.10.30.2-0.20.2-0.2-0.2-0.2
Time in open arm after self-admin0.00.00.0-0.00.2-0.1-0.1-0.1-0.00.2-0.2-0.0-0.00.2-0.0-0.0-0.00.00.00.20.1-0.10.1-0.0-0.0
Bone: periosteal estimation0.30.61.5-1.21.11.2-1.10.71.20.9-0.9-1.11.1-0.7-0.50.40.3-0.3-0.5-0.40.2-0.20.20.40.4
Bone: periosteal perimeter0.30.62.7-1.70.41.3-0.71.11.20.3-0.3-0.90.9-0.1-0.0-0.2-0.1-1.5-0.2-0.7-0.20.2-0.2-0.0-0.0
Bone: post-yield work0.20.32.0-0.40.0-0.1-0.00.3-0.1-0.00.00.1-0.1-0.7-0.70.70.70.6-0.5-1.40.6-0.60.60.50.5
Progressive ratio test 1 active lever presses0.10.11.01.00.20.5-0.3-0.40.20.1-0.1-0.30.30.20.1-0.1-0.20.40.3-0.3-0.30.3-0.3-0.2-0.2
Progressive ratio test 1 breakpoint0.10.21.21.10.30.6-0.3-0.50.30.1-0.2-0.40.40.30.2-0.2-0.30.30.4-0.2-0.40.4-0.4-0.3-0.3
Progressive ratio test 1 inactive lever presses1.62.34.11.91.92.0-2.0-1.81.91.8-1.8-2.02.01.41.3-1.1-1.2-0.61.10.9-1.11.1-1.1-1.0-1.0
Progressive ratio test 2 active lever presses0.20.31.01.00.50.7-0.6-0.70.50.4-0.4-0.60.60.60.5-0.5-0.5-0.00.40.6-0.30.3-0.3-0.3-0.3
Progressive ratio test 2 breakpoint0.20.21.11.00.50.7-0.5-0.70.50.4-0.4-0.60.60.60.5-0.4-0.40.00.30.5-0.20.2-0.2-0.3-0.3
Progressive ratio test 2 inactive lever presses0.00.00.10.3-0.10.3-0.00.20.1-0.20.2-0.10.1-0.0-0.10.10.10.1-0.20.10.2-0.20.20.20.2
Incentive Sensitization - Responses0.71.02.01.21.01.0-1.0-1.21.01.0-1.0-1.01.01.21.2-1.1-1.1-0.81.01.4-0.90.9-0.9-0.9-0.9
Incentive Sensitization - Breakpoint0.70.91.71.10.80.9-0.9-1.10.90.8-0.8-0.90.91.21.2-1.1-1.0-0.80.91.3-0.80.8-0.8-0.9-0.9
Sum of active levers in priming session hrs 5-60.30.31.90.3-0.60.20.40.5-0.1-0.80.80.1-0.10.20.5-0.5-0.8-0.90.41.4-0.20.2-0.2-0.5-0.5
Progressive ratio0.61.01.5-1.2-1.0-1.21.01.1-1.1-1.01.01.1-1.1-1.2-1.11.10.91.0-0.9-0.60.7-0.70.70.90.9
Food seeking constrained by brief footshock0.20.20.60.1-0.8-0.40.70.3-0.5-0.70.70.5-0.50.30.3-0.4-0.3-0.50.4-0.1-0.50.5-0.5-0.4-0.4
Seeking ratio, punishment vs. effort0.30.40.60.70.70.6-0.7-0.70.70.7-0.7-0.70.70.80.7-0.7-0.4-0.70.5-0.2-0.40.4-0.4-0.5-0.5
Retroperitoneal fat weight1.98.313.32.43.53.6-3.6-2.73.53.4-3.4-3.63.62.32.4-2.4-2.7-1.82.33.1-2.42.4-2.4-2.2-2.2
Reaction time number correct0.61.13.61.21.90.8-1.6-1.61.01.9-1.9-1.21.20.50.1-0.20.10.60.5-1.1-0.30.3-0.3-0.3-0.3
Reaction time mean minus median0.10.31.90.5-0.9-0.50.80.1-0.6-0.90.90.6-0.60.10.5-0.2-0.5-0.10.21.4-0.10.1-0.1-0.3-0.3
Reaction time mean minus median AUC0.00.10.20.2-0.3-0.10.2-0.0-0.2-0.30.30.2-0.20.10.2-0.2-0.3-0.20.20.5-0.20.2-0.2-0.3-0.3
Reaction time num false alarms0.10.10.20.0-0.3-0.40.3-0.2-0.3-0.20.20.3-0.30.30.4-0.2-0.2-0.30.2-0.2-0.30.3-0.3-0.2-0.2
Reaction time num false alarms AUC0.10.10.40.0-0.4-0.70.4-0.1-0.5-0.30.30.5-0.50.10.20.10.10.1-0.0-0.3-0.10.1-0.10.00.0
Reaction time trials correct on left0.61.13.61.21.90.8-1.6-1.61.01.9-1.9-1.21.20.50.1-0.20.10.60.5-1.1-0.30.3-0.3-0.3-0.3
Reaction time trials on left0.61.13.71.21.90.8-1.7-1.61.01.9-1.9-1.21.20.40.1-0.20.10.60.5-1.1-0.30.3-0.3-0.3-0.3
Reaction time mean0.30.52.50.30.50.5-0.5-0.30.50.5-0.5-0.50.50.50.6-0.5-1.0-0.70.71.6-0.80.8-0.8-0.8-0.8
Reaction time mean AUC0.30.42.20.20.70.5-0.6-0.40.60.7-0.7-0.60.60.30.5-0.4-0.8-0.40.61.5-0.60.6-0.6-0.6-0.6
Median of all reaction times0.30.41.40.10.70.6-0.7-0.20.70.7-0.7-0.70.60.40.4-0.4-0.8-0.60.61.2-0.70.7-0.7-0.6-0.6
Reaction time omissions0.10.20.60.80.40.3-0.4-0.50.30.4-0.4-0.30.30.10.4-0.2-0.4-0.00.50.4-0.40.4-0.4-0.4-0.4
Reaction time false alarm rate0.40.51.6-0.5-1.3-1.01.20.6-0.9-1.21.21.0-1.00.00.2-0.0-0.1-0.4-0.10.3-0.10.1-0.10.00.0
Reaction time premature initiation rate0.30.41.1-0.0-0.9-1.10.90.3-1.0-0.80.81.0-1.0-0.3-0.30.40.30.5-0.40.40.5-0.50.50.40.4
Reaction time premature initiations0.10.10.60.80.3-0.4-0.2-0.7-0.20.3-0.40.1-0.10.0-0.10.20.20.80.0-0.10.2-0.20.20.10.1
Std. dev. reaction times0.10.11.00.2-0.5-0.60.50.1-0.5-0.40.40.5-0.5-0.10.20.1-0.20.10.11.0-0.00.0-0.0-0.1-0.1
Reaction time trials completed0.61.13.71.21.90.8-1.7-1.61.01.9-1.9-1.21.20.40.1-0.20.10.60.5-1.1-0.30.3-0.3-0.3-0.3
Reaction time trials AUC0.61.23.81.11.90.8-1.7-1.61.11.9-1.9-1.21.20.40.1-0.20.10.50.5-1.2-0.30.3-0.3-0.3-0.3
Run reversals in cocaine runway, females0.10.10.30.30.1-0.4-0.0-0.2-0.20.2-0.20.1-0.10.30.2-0.1-0.10.00.3-0.1-0.50.5-0.5-0.3-0.3
Run reversals in cocaine runway, males1.21.23.60.70.41.1-0.6-0.71.00.4-0.4-0.90.91.71.6-1.5-1.4-1.50.81.9-0.90.9-0.9-0.9-0.9
Latency to leave start box in cocaine runway0.10.10.80.30.1-0.30.0-0.5-0.20.1-0.10.2-0.20.2-0.0-0.0-0.30.30.10.9-0.10.1-0.1-0.1-0.1
Latency to leave start box in cocaine runway, F0.20.31.00.40.9-0.0-0.7-1.00.31.0-1.0-0.30.30.10.10.1-0.10.70.10.8-0.00.0-0.00.00.0
Latency to leave start box in cocaine runway, M0.20.10.40.3-0.6-0.20.50.2-0.3-0.60.60.3-0.30.2-0.1-0.3-0.4-0.50.20.6-0.30.3-0.3-0.2-0.2
Std. dev. time between licks in bursts0.60.92.81.01.70.9-1.5-1.01.01.6-1.6-1.21.2-0.2-0.20.50.41.00.1-0.70.1-0.10.10.10.1
Total sessions with >9 infusions0.60.81.5-0.5-0.8-0.80.80.5-0.9-0.80.80.8-0.8-1.0-0.91.10.91.2-1.0-0.50.8-0.80.81.11.1
Short access day 1 total inactive lever presses0.60.72.2-0.50.1-0.20.00.4-0.30.0-0.00.2-0.2-1.2-1.11.30.91.5-1.20.51.0-1.01.01.31.3
Short access day 10 total inactive lever presses0.92.14.91.42.02.2-2.1-1.22.01.8-1.8-2.12.11.21.2-1.0-0.9-0.70.90.4-1.01.0-1.0-0.8-0.8
Short access day 1 total infusions1.82.43.1-1.1-1.4-1.71.51.2-1.7-1.51.41.6-1.7-1.8-1.61.71.61.7-1.5-1.31.6-1.61.61.61.6
Short access day 10 total infusions0.81.02.11.50.61.1-0.7-0.80.90.5-0.5-0.90.91.11.0-1.1-1.2-0.71.20.8-1.21.2-1.2-1.1-1.1
Short access total infusions0.20.20.50.2-0.5-0.40.50.2-0.5-0.60.60.4-0.4-0.5-0.50.50.40.7-0.40.00.5-0.50.50.50.5
Short access day 1 locomotion1.21.52.3-1.2-1.3-1.11.31.4-1.2-1.41.41.2-1.2-1.3-1.21.21.30.9-1.2-1.51.0-1.01.01.21.2
Short access day 10 total locomotion0.20.41.3-0.7-1.1-0.61.01.0-0.8-1.21.20.8-0.8-0.2-0.30.10.20.0-0.2-0.3-0.10.1-0.10.20.2
Short access total locomotion0.60.81.6-0.8-1.2-0.71.11.1-0.9-1.31.30.9-0.9-0.8-0.80.80.80.7-0.9-0.60.4-0.40.40.90.9
One hour access (0.3 mA shock)0.70.81.61.00.80.8-0.8-1.00.80.9-0.9-0.80.81.11.1-1.0-1.1-0.61.01.3-0.80.8-0.8-1.0-1.0
Compulsive drug intake1.31.52.60.91.61.2-1.5-1.41.41.6-1.6-1.41.41.11.1-0.9-1.1-0.51.20.9-1.11.1-1.1-1.1-1.1
One hour access (shock baseline)0.10.20.80.60.40.3-0.3-0.60.30.4-0.4-0.30.30.50.4-0.4-0.6-0.30.50.9-0.30.3-0.3-0.4-0.4
Social response proportion0.91.03.2-0.2-0.5-0.70.60.7-0.8-0.70.60.7-0.7-1.4-1.11.21.41.2-1.1-1.81.1-1.11.11.11.1
Social responses1.11.43.3-0.9-0.4-0.70.50.8-0.7-0.40.40.7-0.7-1.6-1.51.61.71.3-1.4-1.81.4-1.41.41.51.5
Social time0.70.91.8-1.4-0.3-0.60.41.0-0.6-0.30.40.6-0.6-1.3-1.31.11.20.8-1.2-0.81.1-1.11.11.21.2
Soleus weight1.23.74.91.02.02.2-2.1-1.52.22.0-2.0-2.12.11.91.7-1.9-1.9-2.02.01.1-2.02.0-2.0-2.0-2.0
Bone: stiffness1.72.77.7-2.80.20.1-0.22.20.1-0.00.0-0.0-0.0-2.5-2.42.11.71.2-2.2-0.72.0-2.02.02.22.2
Tibialis anterior weight0.10.51.60.30.80.5-0.8-0.80.60.9-0.9-0.60.60.50.5-0.5-0.8-0.50.71.3-0.60.6-0.6-0.6-0.6
Time to tail flick, vehicle, before self-admin0.00.00.2-0.1-0.1-0.30.2-0.2-0.2-0.10.10.2-0.20.10.2-0.10.20.1-0.1-0.50.1-0.10.10.10.1
Time to tail flick, vehicle, after self-admin1.62.13.2-1.6-1.1-1.61.21.3-1.4-1.01.01.5-1.5-1.6-1.81.81.51.4-1.5-0.71.5-1.51.51.51.5
Time to tail flick, test, before self-admin0.10.10.40.5-0.1-0.00.10.0-0.2-0.10.10.1-0.1-0.2-0.20.30.10.7-0.10.10.3-0.30.30.20.2
Time to tail flick, test, after self-admin1.71.82.5-0.4-1.5-1.21.51.1-1.5-1.61.61.4-1.4-1.2-1.21.21.41.4-1.2-1.41.4-1.41.41.21.2
Delta time to tail flick, vehicle, before/after SA0.10.10.90.10.40.0-0.3-0.20.10.4-0.4-0.10.1-0.0-0.20.3-0.40.20.40.9-0.20.2-0.2-0.3-0.3
Delta time to tail flick, test, before/after SA1.71.72.9-1.5-1.5-1.31.41.7-1.3-1.61.61.4-1.4-1.2-1.31.11.20.4-1.3-0.91.2-1.21.21.21.2
Tibia length1.64.413.5-2.82.53.7-2.81.03.52.2-2.2-3.13.10.60.6-1.1-1.3-3.30.50.6-1.11.1-1.1-0.9-0.9
Ambulatory time before self-admin0.20.31.3-0.10.51.2-0.70.21.00.4-0.4-0.90.90.50.5-0.3-0.1-0.40.1-0.9-0.20.2-0.2-0.2-0.2
Ambulatory time after self-admin0.60.72.41.50.70.8-0.8-1.30.80.7-0.7-0.90.91.01.5-0.8-0.7-0.20.60.7-0.30.3-0.3-0.6-0.6
Bone: tissue strength0.50.51.6-0.91.31.1-1.20.21.21.2-1.2-1.11.1-0.3-0.40.1-0.1-0.20.0-0.1-0.00.0-0.0-0.1-0.1
Total heroin consumption1.72.03.8-1.7-1.6-1.01.42.0-1.2-1.71.71.3-1.3-1.7-1.21.41.20.7-1.5-0.71.5-1.51.51.31.3
Bone: trabecular number0.30.40.80.50.30.4-0.3-0.60.40.4-0.4-0.40.40.80.7-0.8-0.8-0.90.90.2-0.80.8-0.8-0.9-0.9
Bone: trabecular spacing0.50.72.00.81.40.7-1.2-0.90.81.3-1.4-0.90.9-0.4-0.30.50.51.2-0.1-0.50.3-0.30.30.40.4
Bone: trabecular thickness0.60.83.9-0.0-0.30.50.1-0.10.4-0.30.3-0.20.21.11.2-1.3-1.1-2.00.80.4-1.11.1-1.1-1.0-1.0
Bone: trabecular tissue density0.60.91.9-0.4-0.9-1.21.00.7-1.2-1.00.91.1-1.1-1.0-0.91.11.01.4-0.7-1.01.0-1.01.00.70.7
Water consumed over 24 hours0.30.31.00.2-0.4-0.10.3-0.3-0.1-0.30.30.2-0.20.80.7-0.8-0.7-1.00.70.1-0.80.8-0.8-0.8-0.8
Number of responses in last shaping day1.41.52.8-1.1-0.8-0.80.81.3-0.9-0.90.90.9-0.9-1.3-1.51.51.41.2-1.6-0.41.4-1.41.41.71.7