Hells

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	NM_001106371.1	0.06	0.04	8.6e-07	0.06	0.05	0.05	0.06	6.9e-07	3.8e-06	1.4e-06	1.0e-06
2	Liver	alternative polyA	XM_017589048.3	0.07	0.04	2.8e-07	0.06	0.05	0.06	0.06	9.6e-08	1.1e-06	7.5e-07	5.9e-07
3	IL	gene expression	Hells	0.14	0.1	6.4e-03	0.14	0.07	0.07	0.09	3.2e-04	8.3e-03	8.4e-03	2.9e-03
4	Liver	isoform ratio	XM_017589048.3	0.05	0.03	1.1e-05	0.04	0.04	0.04	0.04	1.2e-05	9.3e-06	1.1e-05	1.5e-05
5	Liver	isoform ratio	NM_001106371.1	0.05	0.03	3.1e-05	0.04	0.04	0.04	0.04	3.1e-05	3.0e-05	3.3e-05	3.5e-05
6	IC	gene expression	Hells	0.12	0.07	1.9e-04	0.06	0.06	0.03	0.05	2.2e-03	1.6e-03	1.5e-02	3.2e-03
7	Liver	gene expression	Hells	0.05	0.04	3.4e-04	0.02	0.03	0.03	0.03	2.0e-03	3.2e-04	6.1e-04	8.4e-04
8	PL	gene expression	Hells	0.16	0.12	1.8e-03	0	0.01	-0	0	2.6e-01	1.3e-02	6.0e-01	1.5e-01
9	Brain	gene expression	Hells	0.03	0.03	3.3e-03	0.01	0.02	0.02	0.02	3.4e-02	5.6e-03	6.8e-03	9.2e-03
10	Adipose	gene expression	Hells	0.04	0.04	6.3e-03	0.01	0	0	0.01	4.3e-02	9.5e-02	8.0e-02	6.2e-02
11	LHb	gene expression	Hells	0.27	0.14	1.7e-05	0.21	0.19	0.21	0.2	8.9e-06	3.1e-05	8.8e-06	1.5e-05
12	pVTA	gene expression	Hells	0.04	0.03	2.9e-04	0.06	0.04	0.04	0.04	1.8e-05	1.7e-04	5.6e-04	4.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	2.0	3.8	7.1	2.5	-2.5	-2.7	2.3	-2.3	1.8	2.2	0.7	1.4	-1.4	-1.1	-1.0
Area under the delay curve	0.9	1.4	4.0	-0.7	0.7	0.3	-0.4	0.4	-1.3	-0.4	-2.0	-1.5	1.3	1.7	1.6
BMI with tail	0.5	1.9	2.7	1.3	-1.3	-1.0	1.6	-1.6	1.5	1.6	1.5	1.4	-1.1	-1.1	-1.0
BMI without tail	0.1	0.3	1.5	0.2	-0.2	0.3	0.1	-0.1	0.4	0.2	1.2	0.6	-0.8	-0.5	-0.3
Body weight	0.2	1.1	3.3	0.7	-0.7	-0.2	0.3	-0.2	1.1	0.3	1.7	1.2	-1.8	-1.3	-1.2
Weight adjusted by age	0.0	0.1	0.6	0.0	-0.0	-0.1	0.3	-0.2	0.4	0.2	0.3	0.6	0.1	-0.5	-0.8
Bone surface	2.7	5.2	9.1	2.9	-2.9	-3.0	2.4	-2.4	2.2	2.4	1.4	1.8	-1.9	-1.6	-1.6
Bone volume	2.2	4.5	7.3	2.5	-2.5	-2.7	2.1	-2.1	2.2	2.0	1.4	1.9	-2.1	-1.8	-1.8
Breakpoint value in progressive ratio session	0.2	0.4	1.3	0.0	-0.0	0.4	-0.2	0.2	-1.0	-0.0	-0.3	-1.1	0.8	1.0	1.0
Number of licking bursts	0.8	2.3	4.7	-1.4	1.4	0.7	-0.7	0.7	-1.7	-0.7	-2.2	-1.7	2.1	1.9	1.9
Context. condit. distance diff. score	0.9	1.1	3.2	1.3	-1.3	-1.8	1.2	-1.2	1.0	1.1	0.1	0.6	-0.7	-0.6	-0.6
Locomotion velocity, session 1	3.7	4.2	9.4	-1.7	1.7	1.1	-1.2	1.2	-2.3	-1.2	-3.1	-2.4	2.3	2.6	2.6
Locomotion distance, session 1	1.5	1.9	3.6	-1.3	1.3	0.9	-0.9	0.9	-1.5	-0.9	-1.9	-1.6	1.5	1.6	1.6
Locomotion velocity, session 2	1.4	1.7	2.5	1.0	-1.0	-1.1	1.5	-1.5	-0.6	1.6	-1.2	-1.3	1.3	1.6	1.6
Locomotion distance, session 2	0.4	0.5	1.1	0.2	-0.2	-0.1	0.5	-0.5	-0.7	0.6	-0.9	-1.0	0.9	1.1	1.0
Locomotion velocity, session 3	0.1	0.1	0.2	0.1	-0.1	-0.3	0.4	-0.4	0.2	0.4	0.0	-0.1	-0.0	-0.1	-0.1
Locomotion distance, session 3	0.1	0.2	0.7	0.1	-0.1	0.3	-0.3	0.3	0.4	-0.3	0.2	0.3	-0.8	-0.6	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	1.2	-0.1	0.1	-0.9	0.0	-0.1	-0.3	-0.0	-1.1	-0.4	0.3	0.4	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.8	0.2	-0.2	-1.2	0.4	-0.5	-0.3	0.4	-1.3	-0.7	0.7	0.8	0.8
Locomotion velocity, session 7	1.8	1.9	5.0	1.8	-1.8	-2.2	1.3	-1.3	1.5	1.1	0.1	1.0	-1.2	-1.2	-1.2
Locomotion distance, session 7	1.9	2.4	3.4	1.8	-1.8	-1.8	1.2	-1.2	1.7	1.1	1.2	1.5	-1.6	-1.6	-1.6
Stereotopy head waving bouts, day 7	1.5	1.7	4.4	-0.6	0.6	-0.3	-0.5	0.5	-1.6	-0.5	-2.1	-1.9	1.4	1.8	1.8
Stereotopy head waving duration, day 7	0.8	1.0	3.6	-0.5	0.5	-0.3	-0.5	0.5	-1.0	-0.6	-1.9	-1.3	0.7	1.3	1.3
Locomotion velocity, session 8	0.2	0.3	0.5	0.5	-0.5	-0.6	0.7	-0.7	0.0	0.7	-0.5	-0.4	0.3	0.3	0.2
Locomotion distance, session 8	0.9	1.3	3.0	1.4	-1.4	-1.7	1.6	-1.6	0.3	1.7	-0.2	-0.3	0.2	0.2	0.2
Degree of sensitization distance	0.6	0.6	2.1	1.0	-1.0	-1.4	1.0	-1.0	0.2	1.0	-0.1	0.1	0.2	0.2	0.2
Degree of sensitization stereotypy	1.7	1.9	3.9	-0.9	0.9	0.3	-0.8	0.8	-1.8	-0.8	-1.7	-2.0	1.5	1.9	1.9
Conditioned locomotion	0.7	0.8	2.2	0.3	-0.3	-0.2	-0.1	0.1	1.1	-0.3	0.7	1.4	-1.5	-1.4	-1.3
Cocaine response after cond. corrected	0.0	0.1	0.2	-0.0	0.0	-0.2	0.2	-0.2	-0.2	0.3	-0.2	-0.3	0.5	0.3	0.4
Cocaine response after cond. not corrected	0.1	0.2	0.6	-0.1	0.1	-0.6	0.3	-0.3	-0.4	0.4	-0.3	-0.7	0.8	0.5	0.6
Cocaine response before conditioning	0.4	0.5	1.3	-0.4	0.4	-0.4	-0.2	0.2	-0.8	-0.1	-0.9	-1.1	1.1	1.0	1.0
Saline control response	2.1	2.9	4.7	-1.9	1.9	1.3	-1.7	1.8	-2.2	-1.6	-1.2	-1.9	1.8	1.7	1.6
Bone: connectivity density	3.6	5.7	9.3	3.0	-3.0	-2.5	2.8	-2.8	2.3	2.7	1.4	2.0	-2.0	-1.7	-1.6
Bone: cortical apparent density	0.8	1.3	2.8	-0.8	0.8	0.5	-0.7	0.7	-1.3	-0.7	-1.7	-1.3	1.4	1.5	1.5
Bone: cortical area	0.8	1.2	3.0	0.9	-0.9	-1.2	0.1	-0.1	1.1	0.1	1.4	1.2	-1.7	-1.5	-1.5
Bone: cortical porosity	1.6	1.8	4.2	1.5	-1.5	-2.1	1.9	-1.9	0.5	1.9	-0.9	-0.2	0.4	0.4	0.4
Bone: cortical porosity	1.4	1.5	4.1	1.5	-1.5	-2.0	1.8	-1.8	0.7	1.7	-0.4	0.0	0.2	0.1	0.1
Bone: cortical thickness	1.1	1.9	4.1	-1.6	1.6	0.7	-2.0	2.0	-1.4	-2.0	-0.7	-1.1	0.6	0.6	0.6
Bone: cortical thickness	2.7	3.3	4.5	-1.8	1.8	0.8	-1.8	1.8	-2.1	-1.7	-1.8	-2.0	1.8	1.9	1.9
Bone: cortical tissue density	0.8	1.3	3.0	-0.8	0.8	0.5	-0.5	0.5	-1.3	-0.6	-1.7	-1.3	1.4	1.5	1.5
Condit. Reinf. active minus inactive responses	0.3	0.3	1.2	-0.5	0.5	0.8	-0.3	0.3	-0.5	-0.3	-1.1	-0.5	0.4	0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.0	-0.3	0.3	1.0	-0.3	0.3	-0.3	-0.4	-0.5	-0.2	0.0	0.2	0.2
Condit. Reinf. active responses	0.2	0.3	1.1	-0.5	0.5	0.8	-0.4	0.4	-0.3	-0.5	-1.0	-0.3	0.3	0.4	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.7	-0.3	0.3	-0.3	-0.1	0.1	-0.2	-0.2	-0.9	-0.3	0.5	0.4	0.4
Incentive salience index mean	0.6	0.8	2.6	-0.9	0.9	1.6	-0.8	0.8	-0.8	-0.8	-0.6	-0.7	0.7	0.6	0.6
Condit. Reinf. lever presses	1.2	1.8	5.1	-1.6	1.6	2.3	-1.5	1.5	-1.2	-1.4	-0.3	-0.9	1.2	0.8	0.7
Condit. Reinf. active minus inactive responses	2.0	3.1	4.8	1.7	-1.7	-2.2	1.5	-1.5	2.0	1.4	1.4	2.0	-1.9	-1.8	-1.7
Condit. Reinf. active-inactive response ratio	1.2	2.0	3.5	1.4	-1.4	-1.9	1.4	-1.3	1.6	1.3	1.2	1.5	-1.5	-1.2	-1.2
Condit. Reinf. active responses	0.7	1.1	2.4	0.3	-0.3	-0.7	0.1	-0.1	1.2	0.0	1.3	1.4	-1.5	-1.5	-1.4
Condit. Reinf. inactive responses	1.0	1.5	3.3	-1.5	1.5	1.7	-1.8	1.8	-0.7	-1.8	0.1	-0.3	0.1	-0.1	-0.1
Condit. Reinf. lever presses	0.3	0.4	0.8	-0.9	0.9	0.3	-0.8	0.8	-0.7	-0.7	-0.0	-0.6	0.4	0.3	0.3
Condit. Reinf. lever reinforcers received	0.3	0.5	1.2	0.0	-0.0	-0.6	-0.1	0.1	0.8	-0.2	0.9	0.9	-1.1	-1.0	-1.0
Conditioned reinforcement - actives	0.1	0.4	1.0	0.2	-0.2	-0.4	0.4	-0.4	-0.6	0.6	-0.5	-1.0	0.9	0.7	0.6
Conditioned reinforcement - inactives	0.5	1.3	3.8	0.7	-0.7	-0.6	1.1	-1.2	-0.5	1.1	-1.9	-1.3	1.3	1.1	1.0
Conditioned locomotion	0.3	0.4	0.7	-0.5	0.5	0.8	-0.4	0.4	-0.6	-0.4	-0.9	-0.7	0.8	0.6	0.7
Patch foraging indifference point 0 sec	0.4	1.1	2.5	-1.3	1.3	1.6	-1.4	1.4	-0.9	-1.4	0.1	-0.5	0.3	0.2	0.2
Patch foraging indifference point AUC	2.4	5.8	8.8	-2.2	2.2	1.9	-2.3	2.3	-3.0	-2.1	-2.2	-2.8	2.6	2.7	2.6
Delay disc. indifference point, 0s delay	0.8	0.9	2.4	1.1	-1.1	-1.5	1.4	-1.4	0.7	1.4	0.1	0.5	-0.1	-0.1	-0.2
Delay disc. indifference point, 16s delay	0.6	0.8	1.8	-0.7	0.7	0.6	-0.4	0.4	-1.2	-0.3	-1.1	-1.3	0.9	1.3	1.2
Delay disc. indifference point, 2s delay	0.1	0.2	0.6	0.4	-0.4	-0.3	0.2	-0.2	-0.2	0.2	-0.8	-0.2	0.2	0.6	0.6
Delay disc. indifference point, 24s delay	1.6	2.5	5.2	-1.3	1.3	1.0	-1.0	1.0	-1.9	-1.0	-2.3	-2.1	1.6	2.0	1.9
Delay disc. indifference point, 4s delay	0.7	0.7	2.2	-0.4	0.4	0.0	0.0	-0.0	-1.1	0.1	-1.0	-1.2	1.5	1.1	1.1
Delay disc. indifference point, 8s delay	2.5	4.1	10.5	-1.7	1.7	1.2	-1.5	1.5	-2.1	-1.6	-3.2	-2.2	2.0	2.4	2.4
Indifference point function ln k	1.9	5.8	8.4	2.5	-2.5	-1.8	2.2	-2.2	2.9	2.1	2.1	2.7	-2.7	-2.6	-2.5
Indifference point function log k	1.9	5.8	8.4	2.5	-2.5	-1.8	2.2	-2.2	2.9	2.1	2.1	2.7	-2.7	-2.6	-2.5
Patch foraging total patch changes 0 sec	0.4	1.2	2.5	-1.4	1.4	1.6	-1.5	1.5	-0.8	-1.5	0.1	-0.5	0.2	0.1	0.0
Patch foraging total patch changes 12 sec	5.1	6.8	8.8	-2.8	2.8	2.5	-2.6	2.6	-3.0	-2.5	-1.9	-2.6	2.7	2.5	2.5
Patch foraging total patch changes 18 sec	0.8	1.9	3.1	-1.3	1.3	1.0	-1.4	1.4	-1.8	-1.3	-1.1	-1.6	1.3	1.6	1.6
Patch foraging total patch changes 24 sec	0.4	1.4	2.2	-1.3	1.3	1.2	-1.5	1.5	-1.3	-1.4	-0.8	-1.1	0.6	0.9	0.9
Patch foraging total patch changes 6 sec	4.3	7.3	9.8	-3.0	3.0	2.7	-2.8	2.8	-3.1	-2.7	-1.9	-2.9	2.5	2.5	2.4
Patch foraging time to switch 0 sec	0.2	0.9	1.7	-1.0	1.0	0.7	-0.3	0.3	-1.0	-0.3	-0.9	-0.9	1.3	1.2	1.2
Patch foraging water rate 0 sec	0.3	1.3	1.7	1.2	-1.2	-1.2	0.8	-0.8	1.3	0.8	1.1	1.2	-1.2	-1.3	-1.3
Patch foraging water rate 12 sec	0.1	0.4	1.5	0.5	-0.5	-1.2	0.3	-0.3	0.8	0.3	0.6	0.7	-0.5	-0.8	-0.8
Patch foraging water rate 18 sec	0.5	1.1	4.2	1.1	-1.1	-2.1	1.0	-1.0	0.9	1.0	0.6	0.6	-1.1	-0.7	-0.7
Patch foraging water rate 24 sec	0.5	0.7	1.3	0.9	-0.9	-1.1	0.8	-0.9	1.0	0.8	0.6	0.8	-0.9	-0.7	-0.7
Patch foraging water rate 6 sec	0.1	0.1	0.4	0.4	-0.4	-0.6	0.3	-0.3	0.4	0.3	0.3	0.3	-0.1	-0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.6	-0.2	0.2	0.2	-0.8	0.8	-0.3	-0.7	0.3	-0.0	-0.4	0.2	0.3
Distance traveled before self-admin	0.3	0.8	2.1	1.2	-1.2	-1.4	1.0	-1.1	0.3	1.1	0.2	0.1	-0.6	-0.3	-0.3
Distance traveled after self-admin	1.4	2.5	7.4	2.0	-2.0	-2.7	1.7	-1.7	0.9	1.8	0.8	0.7	-0.7	-1.1	-1.2
Extensor digitorum longus weight	0.2	1.0	2.8	1.3	-1.3	-0.9	0.7	-0.7	1.0	0.5	0.3	1.0	-1.7	-0.9	-0.8
Bone: elastic displacement	0.1	0.1	0.2	-0.1	0.1	-0.2	-0.0	0.0	0.2	-0.2	-0.4	0.5	0.2	-0.3	-0.3
Bone: elastic work	0.4	0.5	2.6	0.6	-0.6	-1.6	0.7	-0.7	0.5	0.7	0.1	0.5	-0.1	-0.3	-0.4
Bone: endosteal estimation	4.0	9.9	14.3	3.8	-3.8	-3.1	3.4	-3.4	3.3	3.3	2.4	2.8	-2.9	-2.6	-2.5
Bone: endosteal perimeter	3.9	9.7	12.2	3.5	-3.5	-3.4	3.3	-3.3	3.3	3.3	2.8	2.9	-2.9	-2.6	-2.6
Epididymis fat weight	0.7	3.4	7.3	1.6	-1.6	-1.0	1.0	-1.0	2.3	0.8	1.8	2.5	-2.7	-2.3	-2.3
Delta time in closed arm before/after self-admin	0.5	0.5	1.4	-0.9	0.9	1.2	-0.9	0.9	-0.1	-1.0	-0.3	0.0	0.1	0.0	0.0
Delta time in open arm before/after self-admin	1.6	1.9	5.1	1.7	-1.7	-1.4	2.0	-2.0	0.6	2.3	1.4	0.2	-0.1	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.5	1.0	1.7	1.2	-1.2	-0.9	1.3	-1.3	1.1	1.2	0.6	0.7	-0.9	-0.4	-0.4
Delay discount exponential model param	1.0	1.4	3.8	0.7	-0.7	-0.3	0.4	-0.4	1.4	0.4	1.9	1.6	-1.4	-1.6	-1.6
Extinction: sum of active levers before priming	0.1	0.1	0.5	0.1	-0.1	0.4	-0.2	0.2	0.1	-0.2	0.5	0.1	-0.7	0.0	0.1
Active lever presses in extinction session 6	3.7	3.7	8.5	2.5	-2.5	-2.2	2.9	-2.9	1.1	2.9	-0.1	0.3	-0.2	-0.2	-0.2
Bone: final force	0.1	0.2	0.7	0.5	-0.5	-0.8	0.2	-0.3	0.2	0.3	0.7	0.1	-0.5	-0.4	-0.4
Bone: final moment	0.2	0.3	0.7	0.4	-0.4	-0.8	0.2	-0.2	0.4	0.2	0.7	0.3	-0.7	-0.7	-0.7
Food consumed during 24 hour testing period	0.3	0.7	1.9	-0.7	0.7	-0.2	-0.7	0.7	-0.8	-0.7	-1.4	-0.9	0.7	0.9	0.9
Glucose	0.1	0.2	0.5	0.1	-0.1	-0.0	0.0	-0.0	0.5	0.1	0.7	0.5	-0.5	-0.7	-0.7
Heart weight	0.8	1.2	2.1	-0.5	0.5	0.9	-1.3	1.3	0.5	-1.4	1.1	1.1	-1.3	-1.3	-1.3
Delay discount hyperbolic model param	0.8	1.0	3.0	0.6	-0.6	-0.2	0.3	-0.3	1.2	0.3	1.7	1.3	-1.2	-1.4	-1.3
Intermittent access intake day 1-15 change	0.4	2.4	3.8	2.0	-2.0	-1.2	1.7	-1.7	1.4	1.7	1.4	1.2	-1.5	-1.3	-1.2
Intermittent access intake escalation	0.6	3.3	4.9	2.2	-2.2	-1.5	1.9	-1.9	1.7	2.0	1.7	1.4	-1.7	-1.7	-1.6
Intermittent access intake escalation 2	2.3	3.8	6.3	2.5	-2.5	-2.0	2.4	-2.4	1.7	2.5	1.6	1.2	-1.3	-1.3	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.6	0.8	-0.8	-0.4	0.7	-0.7	0.3	0.6	-0.3	0.2	0.1	0.1	0.1
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.5	0.4	-0.4	-0.5	0.4	-0.4	0.7	0.3	-0.4	0.6	-0.4	-0.4	-0.5
Intermitt. access escalation Index	0.1	0.4	1.4	0.2	-0.2	-0.7	0.0	-0.0	0.8	-0.1	0.4	1.0	-0.5	-1.2	-1.2
Intermittent access day 1 total infusions	0.1	0.2	0.6	0.2	-0.2	0.1	0.6	-0.6	0.0	0.6	-0.8	-0.4	0.5	0.2	0.1
Intermittent access day 15 total infusions	0.8	1.9	2.6	1.5	-1.5	-0.7	1.4	-1.4	1.5	1.4	1.3	1.2	-1.2	-1.6	-1.6
Intermittent access terminal intake (last 3 days)	0.7	1.2	2.1	1.4	-1.4	-1.0	1.4	-1.5	1.0	1.4	0.3	0.5	-0.6	-0.8	-0.8
Intermittent access total infusions	0.3	0.3	0.7	0.6	-0.6	-0.3	0.8	-0.8	0.6	0.7	-0.2	0.3	-0.3	-0.5	-0.5
Intermittent access day 1 locomotion	0.3	0.5	0.7	0.6	-0.6	0.2	0.8	-0.8	0.8	0.8	0.7	0.6	-0.3	-0.8	-0.8
Intermittent access day 15 total locomotion	0.2	0.6	1.5	-0.2	0.2	0.8	0.2	-0.2	-0.7	0.3	-1.1	-1.0	1.1	1.1	1.2
Intermittent access total locomotion	0.4	0.5	1.1	0.5	-0.5	-0.1	1.0	-1.0	-0.0	1.0	-0.9	-0.5	0.5	0.6	0.6
Intermittent access standard deviation	0.4	2.0	3.9	1.9	-1.9	-1.4	1.9	-1.9	1.1	2.0	1.0	0.6	-0.6	-0.7	-0.6
Left kidney weight	0.1	0.5	1.1	-0.7	0.7	0.6	-1.0	1.0	-0.6	-1.0	-0.2	-0.5	0.2	0.4	0.4
Right kidney weight	0.3	2.2	4.2	-1.8	1.8	1.8	-2.1	2.1	-1.3	-2.0	-0.5	-0.9	0.4	0.7	0.8
Cocaine induced anxiety	0.6	1.6	2.4	1.6	-1.6	-1.0	1.4	-1.4	1.4	1.3	0.4	1.1	-1.5	-0.8	-0.7
Post-drug Anxiety	0.7	0.7	3.0	0.4	-0.4	0.3	-0.1	0.2	1.1	-0.3	0.6	1.5	-1.7	-1.1	-0.8
Baseline Anxiety	0.6	1.1	2.6	-1.3	1.3	0.8	-1.6	1.6	-0.1	-1.6	0.7	0.5	-0.0	-0.6	-0.4
Tail length	0.1	0.5	1.3	-0.4	0.4	0.4	-1.0	0.9	0.1	-0.9	0.8	0.3	-1.1	-0.5	-0.4
Length with tail	0.1	0.5	1.4	-0.5	0.5	0.4	-1.2	1.2	-0.5	-1.1	0.2	-0.4	-0.7	-0.0	-0.0
Length without tail	0.1	0.3	0.9	0.8	-0.8	-0.9	0.5	-0.5	0.2	0.5	-0.4	-0.2	-0.3	0.1	0.1
Times rat made contact with spout	0.3	0.3	1.2	0.2	-0.2	-1.1	0.5	-0.5	-0.1	0.5	-0.9	-0.4	0.4	0.5	0.5
Lifetime Intake	0.2	0.2	0.4	0.4	-0.4	-0.2	0.6	-0.6	0.5	0.6	-0.2	0.2	-0.1	-0.5	-0.6
Liver weight, left	0.1	0.1	0.4	-0.2	0.2	0.6	-0.5	0.5	-0.1	-0.5	0.3	0.1	-0.3	-0.1	-0.1
Liver weight, right	0.4	0.7	1.2	0.8	-0.8	-0.8	0.6	-0.6	0.8	0.7	1.1	0.7	-1.0	-0.8	-0.8
Locomotor activity	0.1	0.1	1.3	0.2	-0.2	-1.1	-0.0	0.0	-0.1	-0.0	-0.1	-0.2	-0.2	0.1	0.3
Locomotor testing distance	0.1	0.2	1.1	-0.0	0.0	-1.0	-0.2	0.2	-0.4	-0.1	-0.1	-0.4	0.3	0.4	0.5
Locomotor testing rearing	0.2	0.9	2.7	1.2	-1.2	-1.6	1.0	-1.0	0.6	1.1	0.8	0.6	-0.6	-0.5	-0.4
Locomotion in novel chamber	4.2	5.6	12.8	2.4	-2.4	-3.6	2.7	-2.7	2.3	2.7	2.1	1.9	-1.3	-1.9	-1.9
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	-0.1	0.1	-0.6	0.1	-0.1	-0.5	0.3	0.6	-0.6	0.5	0.2	0.2
Fecal boli incidents, locomotor time 1	0.3	0.8	2.6	1.2	-1.2	-1.6	0.9	-0.9	0.3	0.8	-1.1	-0.2	-0.3	0.1	0.1
Change in fecal boli incidents, locomotor task	0.8	0.9	2.9	-1.3	1.3	1.7	-0.9	0.9	-0.5	-0.8	0.9	-0.1	0.7	0.1	0.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	1.0	-0.1	0.1	0.0	-0.2	0.2	-0.4	-0.1	0.0	-0.7	0.1	0.8	1.0
Bouts of movement, locomotor time 1	0.7	0.9	3.9	-0.3	0.3	0.1	-0.5	0.5	-1.0	-0.6	-2.0	-1.2	0.9	1.1	1.0
Total resting periods, locomotor time 1	1.4	1.6	5.6	-0.5	0.5	-0.1	-0.6	0.5	-1.5	-0.6	-2.4	-1.8	1.4	1.6	1.4
Rest time, locomotor task time 1	0.4	0.6	2.1	0.1	-0.1	-0.9	0.3	-0.3	-0.8	0.3	-1.5	-1.1	1.0	0.9	0.8
Distance moved, locomotor task time 1	0.4	1.1	5.2	-0.9	0.9	0.9	-0.8	0.9	0.4	-0.7	2.3	0.9	-0.4	-1.0	-1.1
Vertical activity count, locomotor time 1	0.1	0.5	2.3	-0.3	0.3	1.0	-0.6	0.6	0.2	-0.5	1.5	0.5	-0.7	-0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.8	0.1	-0.1	0.0	-0.0	0.0	-0.5	0.0	-0.7	-0.8	0.6	0.9	0.9
Bouts of movement, locomotor time 2	1.1	3.6	6.8	-1.3	1.3	1.2	-0.9	0.9	-2.3	-0.8	-2.3	-2.4	2.4	2.5	2.6
Total resting periods, locomotor time 2	1.0	4.0	7.4	-1.3	1.3	1.2	-0.9	0.9	-2.5	-0.8	-2.5	-2.6	2.6	2.7	2.7
Rest time, locomotor task time 2	0.7	1.1	2.8	-0.6	0.6	-0.2	-0.2	0.2	-1.4	-0.1	-1.4	-1.6	1.7	1.3	1.2
Distance moved, locomotor task time 2	0.7	0.9	2.5	0.2	-0.2	-0.0	0.0	-0.0	1.3	-0.0	1.6	1.4	-1.0	-1.4	-1.4
Vertical activity count, locomotor time 2	0.1	0.2	0.7	0.4	-0.4	-0.2	0.2	-0.2	0.6	0.1	0.4	0.5	-0.9	-0.5	-0.4
Light reinforcement 1	0.1	0.4	0.6	-0.7	0.7	0.1	-0.8	0.8	-0.7	-0.7	-0.5	-0.5	0.8	0.6	0.6
Light reinforcement 2	1.2	2.6	9.1	-1.2	1.2	-0.3	-1.0	1.0	-1.8	-1.1	-3.0	-1.8	2.0	1.8	1.7
Bone: marrow area	4.1	10.0	14.8	3.8	-3.8	-3.2	3.5	-3.5	3.3	3.4	2.3	2.8	-2.9	-2.5	-2.5
Bone: maximum diameter	4.7	9.5	12.6	3.5	-3.5	-3.6	2.8	-2.8	3.2	2.8	2.8	2.9	-3.2	-2.9	-2.9
Bone: maximum force	0.5	1.1	2.7	1.2	-1.2	-1.7	1.3	-1.3	0.9	1.3	0.6	0.5	-0.8	-0.5	-0.5
Bone: maximum moment	0.6	1.1	2.7	1.1	-1.1	-1.6	1.1	-1.2	1.0	1.1	0.6	0.7	-1.0	-0.7	-0.7
Mean time between licks in bursts	0.1	0.8	1.6	-1.0	1.0	1.2	-1.1	1.1	0.1	-1.1	0.9	0.6	-0.7	-0.7	-0.7
Mean num. licks in bursts	1.1	2.9	4.0	1.7	-1.7	-1.5	1.3	-1.4	1.9	1.3	1.8	1.7	-2.0	-1.8	-1.8
Cd content in liver	1.7	1.9	3.9	-1.3	1.3	1.1	-1.5	1.5	-1.3	-1.7	-2.0	-1.1	0.8	1.2	1.2
Co content in liver	2.3	2.7	7.3	-2.1	2.1	1.6	-2.6	2.6	-0.5	-2.7	-0.0	0.3	-0.6	-0.6	-0.5
Cu content in liver	4.8	5.7	8.6	-2.5	2.5	1.3	-1.7	1.7	-2.9	-1.6	-2.6	-2.7	2.9	2.8	2.8
Fe content in liver	2.1	2.6	3.3	-1.7	1.7	1.6	-1.4	1.4	-1.8	-1.4	-1.8	-1.7	1.5	1.7	1.7
K content in liver	0.8	0.8	2.0	0.1	-0.1	-0.5	0.7	-0.8	-0.7	0.9	-0.4	-1.1	1.4	1.3	1.3
Mg content in liver	0.7	0.7	2.1	-0.1	0.1	-0.3	0.5	-0.5	-0.8	0.6	-0.8	-1.1	1.4	1.3	1.2
Mn content in liver	3.4	3.8	8.9	-1.2	1.2	0.1	0.0	-0.0	-2.1	0.1	-2.6	-2.5	3.0	2.9	2.9
Na content in liver	1.0	1.2	2.8	-0.6	0.6	0.2	-0.2	0.2	-1.3	-0.1	-1.2	-1.5	1.7	1.6	1.6
Rb content in liver	0.1	0.1	0.8	-0.2	0.2	-0.9	0.1	-0.1	0.1	-0.0	-0.7	-0.1	-0.0	0.2	0.2
Se content in liver	17.0	20.1	28.1	-4.2	4.2	3.3	-3.5	3.5	-5.3	-3.4	-4.9	-5.2	5.1	5.2	5.2
Sr content in liver	0.4	0.4	0.9	-0.3	0.3	-0.3	-0.3	0.3	-0.8	-0.2	-0.4	-0.8	1.0	0.9	0.9
Zn content in liver	1.8	2.1	3.7	-1.2	1.2	0.5	-1.0	1.0	-1.7	-0.9	-1.6	-1.7	1.9	1.8	1.8
Bone: minimum diameter	6.2	12.0	15.3	3.5	-3.5	-3.0	2.8	-2.8	3.9	2.7	3.8	3.8	-3.9	-3.8	-3.8
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.5	-0.5	-0.3	0.4	-0.4	0.5	0.4	0.2	0.5	-0.6	-0.6	-0.6
Time in novel zone, hab. session 1	0.3	0.3	0.8	-0.5	0.5	0.2	-0.4	0.4	-0.7	-0.3	-0.1	-0.7	0.9	0.6	0.6
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.0	0.0	-0.2	0.3	-0.3	-0.4	0.4	-0.3	-0.6	0.6	0.5	0.4
Total locomotion distance, hab. session 1	1.6	2.2	3.8	-1.4	1.4	1.0	-0.9	0.9	-1.7	-0.9	-1.9	-1.9	1.6	1.8	1.7
Locomotion velocity, hab. session 1	2.7	3.9	5.7	-2.1	2.1	1.6	-1.5	1.5	-2.2	-1.4	-2.3	-2.4	2.0	2.2	2.1
Time in familiar zone, hab. session 2	0.7	0.7	1.9	-0.9	0.9	1.2	-1.2	1.3	-0.1	-1.4	0.0	0.4	-0.5	-0.4	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.1	-0.1	-0.6	0.3	-0.3	-0.4	0.4	-0.4	-0.6	0.7	0.5	0.5
Total zone transitions, hab. session 2	0.6	0.7	2.2	-0.9	0.9	1.5	-0.9	0.9	-0.9	-0.8	-0.3	-0.7	0.7	0.6	0.5
Total locomotion distance, hab. session 2	1.5	1.9	3.9	-1.6	1.6	2.0	-1.5	1.5	-1.3	-1.5	-1.4	-1.1	0.8	1.0	1.0
Locomotion velocity, hab. session 2	1.4	1.9	4.0	-1.5	1.5	2.0	-1.3	1.3	-1.4	-1.3	-1.3	-1.3	1.1	1.2	1.2
Novel to familiar place preference ratio	2.7	3.6	8.7	2.1	-2.1	-2.6	2.9	-2.9	0.9	2.9	-0.4	0.0	0.5	0.4	0.4
Novelty place preference	2.9	3.7	9.1	2.1	-2.1	-2.6	3.0	-3.0	0.9	3.0	-0.3	0.1	0.5	0.3	0.3
Time in novel zone, NPP test	2.9	3.5	8.6	2.1	-2.1	-2.5	2.9	-2.9	1.0	2.9	-0.2	0.2	0.4	0.3	0.3
Total zone transitions, NPP test	0.6	0.9	1.5	-1.1	1.1	1.2	-1.1	1.1	-1.0	-1.0	-0.6	-0.9	0.7	0.6	0.6
Total locomotion distance, NPP test	2.8	3.9	5.0	-2.1	2.1	1.8	-1.8	1.8	-2.2	-1.7	-2.2	-2.2	1.8	2.0	1.9
Locomotion velocity, NPP test	2.3	3.3	4.2	-1.9	1.9	1.7	-1.6	1.6	-2.0	-1.6	-2.0	-2.0	1.7	1.8	1.8
Intraocular pressure	0.2	0.4	0.8	-0.9	0.9	0.5	-0.6	0.6	-0.4	-0.7	-0.5	-0.3	0.6	0.4	0.5
Delta distance traveled before/after self-admin	1.7	1.9	2.4	1.4	-1.4	-1.6	1.3	-1.3	1.4	1.3	1.5	1.4	-0.8	-1.4	-1.5
Delta ambulatory time before/after self-admin	1.6	2.8	4.1	1.6	-1.6	-2.0	1.5	-1.5	1.8	1.5	1.8	1.8	-1.2	-1.8	-1.9
Parametrial fat weight	0.6	1.3	3.2	-1.2	1.2	1.5	-1.8	1.8	-0.9	-1.7	0.0	-0.6	-0.2	0.4	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.1	0.1	0.0	-0.3	0.3	0.2	-0.4	0.3	0.5	-0.6	-0.6	-0.6
Pavlov. Cond. magazine entry latency	0.7	1.0	1.4	-1.1	1.1	1.2	-1.1	1.0	-0.9	-1.0	-0.8	-1.0	0.7	0.8	0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.2	0.2	0.3	-0.3	0.2	-0.2	-0.3	-0.6	-0.3	0.2	0.3	0.3
Pavlov. Cond. index score	0.6	0.7	1.2	-0.7	0.7	0.8	-0.5	0.5	-0.9	-0.4	-0.8	-1.1	1.0	1.1	1.1
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.6	0.6	0.7	-0.4	0.4	-0.8	-0.3	-0.5	-0.9	0.9	0.9	0.9
Pavlov. Cond. lever contacts	0.3	0.4	0.8	-0.5	0.5	0.8	-0.3	0.3	-0.7	-0.2	-0.7	-0.8	0.9	0.8	0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	-0.5	-0.5	0.4	-0.4	0.2	0.4	0.5	0.2	-0.2	-0.2	-0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.6	-0.3	0.3	0.4	-0.2	0.2	-0.4	-0.3	-1.3	-0.5	0.4	0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.1	-0.7	0.7	0.9	-0.5	0.5	-0.9	-0.4	-0.9	-1.1	1.0	1.0	1.0
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.5	0.5	0.5	-0.3	0.3	-0.4	-0.3	-0.7	-0.5	0.5	0.5	0.5
Pavlov. Cond. lever latency	1.1	1.6	2.2	1.4	-1.4	-1.2	1.5	-1.5	1.4	1.4	1.1	1.3	-1.0	-1.0	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	2.7	-0.6	0.6	0.4	-0.7	0.7	-0.6	-0.8	-1.7	-0.9	0.6	0.7	0.8
Pavlov. Cond. change in total contacts	0.2	0.5	1.0	-0.9	0.9	0.7	-1.0	1.0	-0.7	-1.0	-0.3	-0.5	0.3	0.3	0.3
Pavlov. Cond. index score	0.9	1.4	2.0	-1.2	1.2	1.1	-1.2	1.2	-1.2	-1.2	-1.4	-1.3	0.9	1.0	1.0
Pavlov. Cond. latency score	0.7	1.2	2.4	-1.0	1.0	0.7	-1.0	1.0	-1.1	-1.1	-1.5	-1.3	0.9	1.0	1.0
Pavlov. Cond. lever contacts	1.3	1.9	2.9	-1.6	1.6	1.6	-1.7	1.7	-1.4	-1.7	-1.0	-1.2	0.9	0.9	0.9
Pavlov. Cond. magazine entry number	2.2	2.8	4.7	1.8	-1.8	-1.4	1.7	-1.7	1.6	1.8	2.2	1.7	-1.3	-1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.7	1.5	2.0	1.4	-1.4	-0.4	1.3	-1.3	1.3	1.3	1.0	1.3	-1.3	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.3	2.3	-1.0	1.0	0.9	-1.1	1.1	-1.2	-1.1	-1.5	-1.3	0.9	1.1	1.1
Pavlov. Cond. response bias	1.4	1.9	2.7	-1.6	1.6	1.5	-1.6	1.6	-1.4	-1.6	-1.2	-1.3	0.9	1.0	0.9
Time in closed arm before self-admin	0.3	0.5	2.8	0.8	-0.8	-1.7	0.8	-0.8	0.2	0.7	-0.7	-0.1	0.0	0.1	0.1
Time in closed arm after self-admin	0.1	0.2	0.7	-0.3	0.3	0.0	-0.7	0.7	-0.2	-0.8	-0.3	0.1	-0.0	-0.2	-0.1
Time in open arm before self-admin	0.2	0.3	1.3	-0.4	0.4	1.2	-0.5	0.5	0.4	-0.6	-0.1	0.6	-0.5	-0.4	-0.3
Time in open arm after self-admin	0.3	0.4	1.3	0.5	-0.5	0.1	0.9	-0.9	-0.0	1.1	0.8	-0.2	0.3	0.2	0.1
Bone: periosteal estimation	2.6	6.3	8.9	3.0	-3.0	-2.6	2.4	-2.4	2.6	2.3	2.2	2.3	-2.7	-2.2	-2.2
Bone: periosteal perimeter	2.7	5.3	6.6	2.5	-2.5	-2.4	2.0	-2.0	2.5	1.9	2.2	2.3	-2.6	-2.3	-2.3
Bone: post-yield work	0.7	1.2	2.0	1.2	-1.2	-1.0	1.4	-1.4	1.2	1.4	0.7	0.9	-1.0	-0.7	-0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.3	-0.3	-0.0	0.5	-0.5	-0.2	0.6	-0.3	-0.4	0.2	0.3	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.1	-0.1	0.2	0.3	-0.3	-0.3	0.4	-0.4	-0.6	0.4	0.4	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.4	1.0	0.5	-0.5	-0.8	1.0	-1.0	0.4	0.9	-0.5	0.0	0.3	0.0	-0.1
Progressive ratio test 2 active lever presses	0.6	0.8	1.8	0.7	-0.7	-1.3	1.3	-1.3	0.2	1.3	-1.2	-0.5	0.5	0.4	0.3
Progressive ratio test 2 breakpoint	0.6	0.8	1.7	0.6	-0.6	-1.2	1.3	-1.3	0.2	1.2	-1.3	-0.5	0.5	0.3	0.3
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.5	0.4	-0.4	-0.6	1.2	-1.2	0.1	1.2	-1.2	-0.5	0.9	0.5	0.4
Incentive Sensitization - Responses	0.5	1.3	3.6	1.0	-1.0	-1.9	1.5	-1.6	0.4	1.5	-1.4	-0.4	0.4	0.3	0.3
Incentive Sensitization - Breakpoint	0.5	1.1	3.2	0.8	-0.8	-1.8	1.3	-1.4	0.2	1.3	-1.5	-0.5	0.5	0.4	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.6	-0.1	0.1	0.8	-0.4	0.4	-0.2	-0.5	-0.4	-0.2	-0.1	0.3	0.4
Progressive ratio	0.2	0.6	1.5	-0.2	0.2	1.2	-0.9	0.9	0.2	-1.1	-0.3	0.6	-0.6	-0.7	-0.8
Food seeking constrained by brief footshock	0.3	0.3	0.7	-0.3	0.3	0.7	-0.4	0.4	-0.7	-0.3	-0.2	-0.8	0.7	0.7	0.7
Seeking ratio, punishment vs. effort	0.3	0.7	1.8	-0.6	0.6	-0.5	0.0	-0.0	-1.0	0.2	-0.1	-1.3	1.1	1.3	1.3
Retroperitoneal fat weight	0.1	0.6	1.5	-0.9	0.9	0.7	-1.1	1.1	0.2	-1.2	0.1	0.6	-0.6	-0.7	-0.7
Reaction time number correct	1.1	3.9	5.6	2.4	-2.4	-2.4	2.2	-2.2	1.9	2.2	1.5	1.6	-1.7	-1.3	-1.3
Reaction time mean minus median	0.1	0.3	1.0	-0.2	0.2	0.4	-0.4	0.4	0.6	-0.5	0.3	0.7	-1.0	-0.9	-0.8
Reaction time mean minus median AUC	0.1	0.4	1.4	-0.1	0.1	0.3	-0.4	0.4	0.7	-0.5	0.2	0.8	-1.2	-0.8	-0.8
Reaction time num false alarms	0.2	0.3	1.3	-0.0	0.0	1.1	-0.6	0.6	-0.1	-0.5	0.7	0.2	-0.5	-0.3	-0.3
Reaction time num false alarms AUC	0.1	0.3	1.4	-0.1	0.1	1.2	-0.6	0.6	0.0	-0.5	0.9	0.3	-0.6	-0.4	-0.5
Reaction time trials correct on left	1.1	3.9	5.6	2.4	-2.4	-2.4	2.2	-2.2	1.9	2.2	1.5	1.6	-1.7	-1.3	-1.3
Reaction time trials on left	1.1	3.8	5.5	2.3	-2.3	-2.3	2.2	-2.2	1.9	2.1	1.5	1.6	-1.8	-1.3	-1.3
Reaction time mean	0.7	1.6	3.5	-1.5	1.5	1.7	-1.8	1.7	-0.8	-1.9	-1.0	-0.5	0.2	0.2	0.2
Reaction time mean AUC	0.7	1.7	3.9	-1.6	1.6	2.0	-1.7	1.7	-0.9	-1.8	-0.9	-0.6	0.4	0.4	0.4
Median of all reaction times	1.1	1.7	3.4	-1.5	1.5	1.5	-1.7	1.7	-1.0	-1.9	-1.4	-0.7	0.5	0.5	0.5
Reaction time omissions	0.3	0.5	1.8	0.4	-0.4	-0.2	-0.3	0.3	1.0	-0.5	-0.3	1.0	-1.4	-0.9	-0.8
Reaction time false alarm rate	1.0	1.3	4.6	-1.2	1.2	2.1	-1.6	1.6	-0.9	-1.5	0.1	-0.5	0.3	0.2	0.2
Reaction time premature initiation rate	0.6	0.9	1.7	-1.3	1.3	0.9	-1.2	1.2	-0.7	-1.1	-0.1	-0.6	1.0	0.4	0.3
Reaction time premature initiations	0.0	0.1	0.2	-0.1	0.1	-0.3	-0.1	0.1	0.2	-0.1	0.5	0.2	-0.0	-0.3	-0.3
Std. dev. reaction times	0.3	1.0	2.1	-1.0	1.0	1.5	-1.3	1.3	0.3	-1.4	0.1	0.6	-0.9	-0.8	-0.8
Reaction time trials completed	1.1	3.8	5.5	2.3	-2.3	-2.3	2.2	-2.2	1.9	2.1	1.5	1.6	-1.8	-1.3	-1.3
Reaction time trials AUC	1.0	3.5	5.2	2.2	-2.2	-2.3	2.1	-2.1	1.8	2.1	1.4	1.6	-1.7	-1.2	-1.2
Run reversals in cocaine runway, females	0.4	0.5	1.4	-0.5	0.5	0.2	-0.1	0.1	-0.8	-0.1	-1.2	-0.8	1.0	1.0	0.7
Run reversals in cocaine runway, males	3.0	3.3	4.5	-2.1	2.1	2.1	-1.9	1.9	-2.1	-1.8	-1.2	-1.9	1.6	1.5	1.4
Latency to leave start box in cocaine runway	2.2	3.1	6.3	1.3	-1.3	-0.9	0.9	-0.9	2.2	0.7	1.8	2.5	-2.3	-2.4	-2.3
Latency to leave start box in cocaine runway, F	3.4	4.3	7.1	1.8	-1.8	-1.3	1.5	-1.5	2.4	1.4	2.5	2.7	-2.5	-2.5	-2.4
Latency to leave start box in cocaine runway, M	0.4	0.3	0.9	0.2	-0.2	-0.0	-0.1	0.1	0.8	-0.3	0.1	1.0	-0.8	-1.0	-0.9
Std. dev. time between licks in bursts	0.8	1.6	3.4	-1.5	1.5	1.4	-1.8	1.8	-1.0	-1.8	-0.9	-0.6	0.6	0.7	0.7
Total sessions with >9 infusions	0.1	0.2	0.5	-0.7	0.7	0.4	-0.3	0.3	-0.4	-0.2	0.3	-0.2	0.5	-0.0	-0.3
Short access day 1 total inactive lever presses	0.9	1.8	3.3	1.6	-1.6	-1.3	1.8	-1.8	1.2	1.7	0.3	1.0	-0.6	-0.8	-1.0
Short access day 10 total inactive lever presses	0.0	0.2	1.1	0.2	-0.2	-0.5	-0.3	0.3	-0.3	-0.4	-1.0	-0.3	0.2	0.5	0.4
Short access day 1 total infusions	0.3	0.6	1.5	-0.9	0.9	0.6	-0.4	0.4	-0.9	-0.4	-1.2	-1.0	1.1	0.6	0.5
Short access day 10 total infusions	0.8	1.3	2.1	-1.5	1.5	1.4	-1.2	1.2	-1.1	-1.2	-1.1	-0.9	1.0	0.7	0.4
Short access total infusions	0.1	0.1	0.4	-0.1	0.1	-0.2	0.2	-0.2	-0.3	0.2	-0.6	-0.4	0.4	0.1	-0.2
Short access day 1 locomotion	0.2	0.3	0.9	0.1	-0.1	-0.3	0.9	-0.9	0.4	1.0	0.7	0.4	0.4	-0.5	-0.7
Short access day 10 total locomotion	0.1	0.4	1.2	-0.2	0.2	0.6	0.3	-0.3	-0.5	0.3	-1.1	-0.8	0.8	0.8	0.7
Short access total locomotion	0.1	0.1	0.6	-0.3	0.3	0.1	0.3	-0.3	-0.3	0.3	-0.2	-0.3	0.8	0.2	0.0
One hour access (0.3 mA shock)	1.7	2.0	5.1	1.5	-1.5	-1.5	2.2	-2.3	1.1	2.2	-0.3	0.3	-0.0	-0.5	-0.6
Compulsive drug intake	0.8	1.1	2.1	0.9	-0.9	-1.0	0.8	-0.8	1.4	0.7	1.1	1.4	-0.7	-1.4	-1.3
One hour access (shock baseline)	0.1	0.2	0.5	0.3	-0.3	0.3	0.7	-0.7	0.1	0.7	-0.2	-0.2	-0.0	-0.1	-0.2
Social response proportion	2.7	3.4	5.9	2.4	-2.4	-1.5	2.3	-2.3	1.8	2.4	1.4	1.4	-0.9	-1.0	-0.9
Social responses	1.0	1.3	3.3	1.3	-1.3	-0.1	1.2	-1.1	1.1	1.3	1.8	1.0	-0.3	-1.0	-1.0
Social time	0.1	0.2	1.3	-0.0	0.0	0.8	0.0	-0.0	-0.2	0.2	1.1	-0.0	0.4	-0.0	-0.0
Soleus weight	1.2	3.7	6.1	2.3	-2.3	-2.5	1.8	-1.8	2.1	1.6	0.7	1.8	-2.3	-1.6	-1.5
Bone: stiffness	0.6	1.1	2.1	1.2	-1.2	-1.4	1.1	-1.1	0.9	1.2	1.0	0.6	-1.0	-0.6	-0.6
Tibialis anterior weight	0.6	2.1	3.7	1.9	-1.9	-1.6	1.5	-1.5	1.4	1.4	0.6	1.1	-1.6	-1.0	-1.0
Time to tail flick, vehicle, before self-admin	0.3	0.4	1.0	-0.3	0.3	-0.2	0.1	-0.1	-0.8	0.2	-0.8	-0.8	1.0	0.9	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.8	0.5	-0.5	-0.6	0.8	-0.8	0.5	0.9	0.8	0.5	-0.2	-0.6	-0.6
Time to tail flick, test, before self-admin	0.5	0.6	1.3	0.8	-0.8	-1.0	1.1	-1.1	0.7	1.1	0.2	0.4	-0.0	-0.4	-0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.4	0.2	-0.2	-0.4	0.2	-0.2	-0.1	0.1	-0.6	-0.1	0.3	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	0.9	0.8	-0.8	-0.6	0.9	-0.9	0.8	0.9	0.4	0.6	-0.7	-0.7	-0.6
Delta time to tail flick, test, before/after SA	0.4	0.4	1.0	-0.5	0.5	0.1	-0.6	0.6	-0.7	-0.7	-1.0	-0.6	0.5	0.8	0.9
Tibia length	0.1	0.3	0.8	-0.7	0.7	0.8	-0.9	0.9	-0.3	-0.9	0.3	-0.0	0.2	-0.2	-0.2
Ambulatory time before self-admin	0.2	0.5	1.3	1.1	-1.1	-0.9	0.9	-0.9	0.2	0.9	0.2	0.0	-0.6	-0.3	-0.4
Ambulatory time after self-admin	2.9	4.6	11.1	2.8	-2.8	-3.3	2.5	-2.5	1.4	2.6	1.1	0.9	-1.0	-1.3	-1.5
Bone: tissue strength	0.2	0.2	0.5	0.3	-0.3	-0.0	0.3	-0.3	0.7	0.2	0.3	0.7	-0.7	-0.6	-0.6
Total heroin consumption	0.2	0.2	0.7	-0.1	0.1	0.3	-0.0	0.0	-0.4	-0.0	-0.7	-0.7	0.4	0.8	0.8
Bone: trabecular number	1.2	2.3	4.3	2.1	-2.1	-2.0	1.8	-1.8	1.4	1.7	0.3	1.1	-1.1	-0.8	-0.7
Bone: trabecular spacing	1.2	1.8	3.8	-1.9	1.9	1.8	-1.8	1.8	-0.9	-1.8	-0.2	-0.5	0.5	0.1	0.1
Bone: trabecular thickness	1.4	1.9	2.7	1.4	-1.4	-1.7	1.3	-1.3	1.5	1.3	1.1	1.4	-1.4	-1.4	-1.4
Bone: trabecular tissue density	0.9	1.5	3.9	1.3	-1.3	-2.0	1.1	-1.0	1.1	1.1	1.5	1.1	-0.9	-1.1	-1.1
Water consumed over 24 hours	0.4	0.7	1.2	0.6	-0.6	-1.1	1.0	-1.0	-0.2	1.0	-1.1	-0.7	0.8	0.8	0.8
Number of responses in last shaping day	0.2	0.2	0.5	-0.7	0.7	0.7	-0.4	0.4	-0.0	-0.4	0.3	0.2	0.2	-0.3	-0.5