Hub : Genes

Hells

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA NM_001106371.1 0.06 0.04 8.6e-07 0.06 0.05 0.05 0.06 6.9e-07 3.8e-06 1.4e-06 1.0e-06
2 Liver alternative polyA XM_017589048.3 0.07 0.04 2.8e-07 0.06 0.05 0.06 0.06 9.6e-08 1.1e-06 7.5e-07 6.0e-07
3 IL gene expression Hells 0.14 0.1 6.3e-03 0.14 0.07 0.09 0.1 3.4e-04 8.1e-03 3.6e-03 2.8e-03
4 Liver isoform ratio XM_017589048.3 0.05 0.03 1.1e-05 0.04 0.04 0.04 0.04 1.2e-05 9.3e-06 1.1e-05 1.5e-05
5 Liver isoform ratio NM_001106371.1 0.05 0.03 3.1e-05 0.04 0.04 0.04 0.04 3.1e-05 3.0e-05 3.3e-05 3.7e-05
6 IC gene expression Hells 0.12 0.07 1.9e-04 0.06 0.06 0.03 0.05 2.2e-03 1.6e-03 1.4e-02 3.1e-03
7 Liver gene expression Hells 0.05 0.04 3.4e-04 0.02 0.03 0.03 0.02 2.0e-03 3.2e-04 6.1e-04 8.6e-04
8 PL gene expression Hells 0.16 0.12 1.8e-03 0 0.01 -0 0 2.6e-01 1.3e-02 5.5e-01 1.6e-01
9 Brain gene expression Hells 0.03 0.03 3.3e-03 0.01 0.02 0.02 0.02 3.4e-02 5.6e-03 6.8e-03 9.1e-03
10 Adipose gene expression Hells 0.04 0.04 6.3e-03 0.01 0 0 0.01 4.3e-02 9.5e-02 8.0e-02 6.5e-02
11 LHb gene expression Hells 0.27 0.14 1.7e-05 0.21 0.19 0.21 0.2 8.9e-06 3.1e-05 8.8e-06 1.4e-05
12 pVTA gene expression Hells 0.04 0.03 2.9e-04 0.06 0.04 0.04 0.04 1.8e-05 1.7e-04 5.6e-04 3.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density2.23.87.1-2.52.52.72.3-2.31.82.20.71.41.41.11.0
Area under the delay curve1.21.44.00.7-0.7-0.3-0.40.4-1.3-0.4-2.0-1.5-1.3-1.7-1.6
BMI with tail0.51.92.7-1.31.31.01.6-1.61.51.61.51.41.11.11.0
BMI without tail0.10.31.5-0.20.2-0.30.1-0.10.40.21.20.60.80.50.3
Body weight0.21.13.3-0.70.70.20.3-0.21.10.31.71.21.81.31.2
Weight adjusted by age0.10.10.6-0.00.00.10.3-0.20.40.20.30.6-0.10.50.8
Bone surface2.95.29.1-2.92.93.02.4-2.42.22.41.41.81.91.61.6
Bone volume2.54.57.3-2.52.52.72.1-2.12.22.01.41.92.11.81.8
Breakpoint value in progressive ratio session0.40.41.3-0.00.0-0.4-0.20.2-1.0-0.0-0.3-1.1-0.8-1.0-1.0
Number of licking bursts1.42.34.71.4-1.4-0.7-0.70.7-1.7-0.7-2.2-1.7-2.1-1.9-1.9
Context. condit. distance diff. score0.91.13.2-1.31.31.81.2-1.21.01.10.10.60.70.60.6
Locomotion velocity, session 13.94.29.41.7-1.7-1.1-1.21.2-2.3-1.2-3.1-2.4-2.3-2.6-2.6
Locomotion distance, session 11.51.93.61.3-1.3-0.9-0.90.9-1.5-0.9-1.9-1.6-1.5-1.6-1.6
Locomotion velocity, session 21.51.72.5-1.01.01.11.5-1.5-0.61.6-1.2-1.3-1.3-1.6-1.6
Locomotion distance, session 20.40.51.1-0.20.20.10.5-0.5-0.70.6-0.9-1.0-0.9-1.1-1.0
Locomotion velocity, session 30.10.10.2-0.10.10.30.4-0.40.20.40.0-0.10.00.10.1
Locomotion distance, session 30.10.20.7-0.10.1-0.3-0.30.30.4-0.30.20.30.80.60.5
Stereotopy head waving bouts, day 30.20.21.20.1-0.10.90.0-0.1-0.3-0.0-1.1-0.4-0.3-0.4-0.4
Stereotopy head waving duration, day 30.40.51.8-0.20.21.20.4-0.5-0.30.4-1.3-0.7-0.7-0.8-0.8
Locomotion velocity, session 71.81.95.0-1.81.82.21.3-1.31.51.10.11.01.21.21.2
Locomotion distance, session 71.92.43.4-1.81.81.81.2-1.21.71.11.21.51.61.61.6
Stereotopy head waving bouts, day 71.51.74.40.6-0.60.3-0.50.5-1.6-0.5-2.1-1.9-1.4-1.8-1.8
Stereotopy head waving duration, day 70.81.03.60.5-0.50.3-0.50.5-1.0-0.6-1.9-1.3-0.7-1.3-1.3
Locomotion velocity, session 80.20.30.5-0.50.50.60.7-0.70.00.7-0.5-0.4-0.3-0.3-0.2
Locomotion distance, session 80.91.33.0-1.41.41.71.6-1.60.31.7-0.2-0.3-0.2-0.2-0.2
Degree of sensitization distance0.60.62.1-1.01.01.41.0-1.00.21.0-0.10.1-0.2-0.2-0.2
Degree of sensitization stereotypy1.81.93.90.9-0.9-0.3-0.80.8-1.8-0.8-1.7-2.0-1.5-1.9-1.9
Conditioned locomotion0.70.82.2-0.30.30.2-0.10.11.1-0.30.71.41.51.41.3
Cocaine response after cond. corrected0.10.10.20.0-0.00.20.2-0.2-0.20.3-0.2-0.3-0.5-0.3-0.4
Cocaine response after cond. not corrected0.20.20.60.1-0.10.60.3-0.3-0.40.4-0.3-0.7-0.8-0.5-0.6
Cocaine response before conditioning0.50.51.30.4-0.40.4-0.20.2-0.8-0.1-0.9-1.1-1.1-1.0-1.0
Saline control response2.22.94.71.9-1.9-1.3-1.71.8-2.2-1.6-1.2-1.9-1.8-1.7-1.6
Bone: connectivity density3.65.79.3-3.03.02.52.8-2.82.32.71.42.02.01.71.6
Bone: cortical apparent density0.91.32.80.8-0.8-0.5-0.70.7-1.3-0.7-1.7-1.3-1.4-1.5-1.5
Bone: cortical area0.81.23.0-0.90.91.20.1-0.11.10.11.41.21.71.51.5
Bone: cortical porosity1.61.84.2-1.51.52.11.9-1.90.51.9-0.9-0.2-0.4-0.4-0.4
Bone: cortical porosity1.41.54.1-1.51.52.01.8-1.80.71.7-0.40.0-0.2-0.1-0.1
Bone: cortical thickness1.11.94.11.6-1.6-0.7-2.02.0-1.4-2.0-0.7-1.1-0.6-0.6-0.6
Bone: cortical thickness2.83.34.51.8-1.8-0.8-1.81.8-2.1-1.7-1.8-2.0-1.8-1.9-1.9
Bone: cortical tissue density0.91.33.00.8-0.8-0.5-0.50.5-1.3-0.6-1.7-1.3-1.4-1.5-1.5
Condit. Reinf. active minus inactive responses0.30.31.20.5-0.5-0.8-0.30.3-0.5-0.3-1.1-0.5-0.4-0.6-0.6
Condit. Reinf. active-inactive response ratio0.20.21.00.3-0.3-1.0-0.30.3-0.3-0.4-0.5-0.2-0.0-0.2-0.2
Condit. Reinf. active responses0.20.31.10.5-0.5-0.8-0.40.4-0.3-0.5-1.0-0.3-0.3-0.4-0.4
Condit. Reinf. inactive responses0.10.20.70.3-0.30.3-0.10.1-0.2-0.2-0.9-0.3-0.5-0.4-0.4
Incentive salience index mean0.60.82.60.9-0.9-1.6-0.80.8-0.8-0.8-0.6-0.7-0.7-0.6-0.6
Condit. Reinf. lever presses1.31.85.11.6-1.6-2.3-1.51.5-1.2-1.4-0.3-0.9-1.2-0.8-0.7
Condit. Reinf. active minus inactive responses2.43.14.8-1.71.72.21.5-1.52.01.41.42.01.91.81.7
Condit. Reinf. active-inactive response ratio1.72.03.5-1.41.41.91.4-1.31.61.31.21.51.51.21.2
Condit. Reinf. active responses0.81.12.4-0.30.30.70.1-0.11.20.01.31.41.51.51.4
Condit. Reinf. inactive responses1.11.53.31.5-1.5-1.7-1.81.8-0.7-1.80.1-0.3-0.10.10.1
Condit. Reinf. lever presses0.30.40.80.9-0.9-0.3-0.80.8-0.7-0.7-0.0-0.6-0.4-0.3-0.3
Condit. Reinf. lever reinforcers received0.30.51.2-0.00.00.6-0.10.10.8-0.20.90.91.11.01.0
Conditioned reinforcement - actives0.20.41.0-0.20.20.40.4-0.4-0.60.6-0.5-1.0-0.9-0.7-0.6
Conditioned reinforcement - inactives0.91.33.8-0.70.70.61.1-1.2-0.51.1-1.9-1.3-1.3-1.1-1.0
Conditioned locomotion0.30.40.70.5-0.5-0.8-0.40.4-0.6-0.4-0.9-0.7-0.8-0.6-0.7
Patch foraging indifference point 0 sec0.61.12.51.3-1.3-1.6-1.41.4-0.9-1.40.1-0.5-0.3-0.2-0.2
Patch foraging indifference point AUC4.05.88.82.2-2.2-1.9-2.32.3-3.0-2.1-2.2-2.8-2.6-2.7-2.6
Delay disc. indifference point, 0s delay0.80.92.4-1.11.11.51.4-1.40.71.40.10.50.10.10.2
Delay disc. indifference point, 16s delay0.70.81.80.7-0.7-0.6-0.40.4-1.2-0.3-1.1-1.3-0.9-1.3-1.2
Delay disc. indifference point, 2s delay0.10.20.6-0.40.40.30.2-0.2-0.20.2-0.8-0.2-0.2-0.6-0.6
Delay disc. indifference point, 24s delay2.22.55.21.3-1.3-1.0-1.01.0-1.9-1.0-2.3-2.1-1.6-2.0-1.9
Delay disc. indifference point, 4s delay0.70.72.20.4-0.4-0.00.0-0.0-1.10.1-1.0-1.2-1.5-1.1-1.1
Delay disc. indifference point, 8s delay3.54.110.51.7-1.7-1.2-1.51.5-2.1-1.6-3.2-2.2-2.0-2.4-2.4
Indifference point function ln k3.35.88.4-2.52.51.82.2-2.22.92.12.12.72.72.62.5
Indifference point function log k3.35.88.4-2.52.51.82.2-2.22.92.12.12.72.72.62.5
Patch foraging total patch changes 0 sec0.61.22.51.4-1.4-1.6-1.51.5-0.8-1.50.1-0.5-0.2-0.1-0.0
Patch foraging total patch changes 12 sec5.36.88.82.8-2.8-2.5-2.62.6-3.0-2.5-1.9-2.6-2.7-2.5-2.5
Patch foraging total patch changes 18 sec1.31.93.11.3-1.3-1.0-1.41.4-1.8-1.3-1.1-1.6-1.3-1.6-1.6
Patch foraging total patch changes 24 sec0.81.42.21.3-1.3-1.2-1.51.5-1.3-1.4-0.8-1.1-0.6-0.9-0.9
Patch foraging total patch changes 6 sec4.87.39.83.0-3.0-2.7-2.82.8-3.1-2.7-1.9-2.9-2.5-2.5-2.4
Patch foraging time to switch 0 sec0.40.91.71.0-1.0-0.7-0.30.3-1.0-0.3-0.9-0.9-1.3-1.2-1.2
Patch foraging water rate 0 sec0.61.31.7-1.21.21.20.8-0.81.30.81.11.21.21.31.3
Patch foraging water rate 12 sec0.20.41.5-0.50.51.20.3-0.30.80.30.60.70.50.80.8
Patch foraging water rate 18 sec0.71.14.2-1.11.12.11.0-1.00.91.00.60.61.10.70.7
Patch foraging water rate 24 sec0.50.71.3-0.90.91.10.8-0.91.00.80.60.80.90.70.7
Patch foraging water rate 6 sec0.10.10.4-0.40.40.60.3-0.30.40.30.30.30.10.30.3
Seeking ratio, delayed vs. immediate footshock0.20.20.60.2-0.2-0.2-0.80.8-0.3-0.70.3-0.00.4-0.2-0.3
Distance traveled before self-admin0.60.82.1-1.21.21.41.0-1.10.31.10.20.10.60.30.3
Distance traveled after self-admin2.02.57.4-2.02.02.71.7-1.70.91.80.80.70.71.11.2
Extensor digitorum longus weight0.21.02.8-1.31.30.90.7-0.71.00.50.31.01.70.90.8
Bone: elastic displacement0.10.10.20.1-0.10.2-0.00.00.2-0.2-0.40.5-0.20.30.3
Bone: elastic work0.40.52.6-0.60.61.60.7-0.70.50.70.10.50.10.30.4
Bone: endosteal estimation4.59.914.3-3.83.83.13.4-3.43.33.32.42.82.92.62.5
Bone: endosteal perimeter4.59.712.2-3.53.53.43.3-3.33.33.32.82.92.92.62.6
Epididymis fat weight1.03.47.3-1.61.61.01.0-1.02.30.81.82.52.72.32.3
Delta time in closed arm before/after self-admin0.50.51.40.9-0.9-1.2-0.90.9-0.1-1.0-0.30.0-0.1-0.0-0.0
Delta time in open arm before/after self-admin1.91.95.1-1.71.71.42.0-2.00.62.31.40.20.10.20.2
Diff in mean of infusions in LGA sessions0.81.01.7-1.21.20.91.3-1.31.11.20.60.70.90.40.4
Delay discount exponential model param1.21.43.8-0.70.70.30.4-0.41.40.41.91.61.41.61.6
Extinction: sum of active levers before priming0.10.10.5-0.10.1-0.4-0.20.20.1-0.20.50.10.7-0.0-0.1
Active lever presses in extinction session 63.73.78.5-2.52.52.22.9-2.91.12.9-0.10.30.20.20.2
Bone: final force0.10.20.7-0.50.50.80.2-0.30.20.30.70.10.50.40.4
Bone: final moment0.20.30.7-0.40.40.80.2-0.20.40.20.70.30.70.70.7
Food consumed during 24 hour testing period0.50.71.90.7-0.70.2-0.70.7-0.8-0.7-1.4-0.9-0.7-0.9-0.9
Glucose0.10.20.5-0.10.10.00.0-0.00.50.10.70.50.50.70.7
Heart weight0.81.22.10.5-0.5-0.9-1.31.30.5-1.41.11.11.31.31.3
Delay discount hyperbolic model param0.91.03.0-0.60.60.20.3-0.31.20.31.71.31.21.41.3
Intermittent access intake day 1-15 change1.22.43.8-2.02.01.21.7-1.71.41.71.41.21.51.31.2
Intermittent access intake escalation1.63.34.9-2.22.21.51.9-1.91.72.01.71.41.71.71.6
Intermittent access intake escalation 23.43.86.3-2.52.52.02.4-2.41.72.51.61.21.31.31.2
Intermitt. access day 1 inactive lever presses0.10.20.6-0.80.80.40.7-0.70.30.6-0.30.2-0.1-0.1-0.1
Intermitt. access day 15 inactive lever presses0.10.20.5-0.40.40.50.4-0.40.70.3-0.40.60.40.40.5
Intermitt. access escalation Index0.30.41.4-0.20.20.70.0-0.00.8-0.10.41.00.51.21.2
Intermittent access day 1 total infusions0.10.20.6-0.20.2-0.10.6-0.60.00.6-0.8-0.4-0.5-0.2-0.1
Intermittent access day 15 total infusions1.31.92.6-1.51.50.71.4-1.41.51.41.31.21.21.61.6
Intermittent access terminal intake (last 3 days)0.91.22.1-1.41.41.01.4-1.51.01.40.30.50.60.80.8
Intermittent access total infusions0.30.30.7-0.60.60.30.8-0.80.60.7-0.20.30.30.50.5
Intermittent access day 1 locomotion0.40.50.7-0.60.6-0.20.8-0.80.80.80.70.60.30.80.8
Intermittent access day 15 total locomotion0.30.61.50.2-0.2-0.80.2-0.2-0.70.3-1.1-1.0-1.1-1.1-1.2
Intermittent access total locomotion0.40.51.1-0.50.50.11.0-1.0-0.01.0-0.9-0.5-0.5-0.6-0.6
Intermittent access standard deviation1.02.03.9-1.91.91.41.9-1.91.12.01.00.60.60.70.6
Left kidney weight0.10.51.10.7-0.7-0.6-1.01.0-0.6-1.0-0.2-0.5-0.2-0.4-0.4
Right kidney weight0.52.24.21.8-1.8-1.8-2.12.1-1.3-2.0-0.5-0.9-0.4-0.7-0.8
Cocaine induced anxiety1.11.62.4-1.61.61.01.4-1.41.41.30.41.11.50.80.7
Post-drug Anxiety0.70.73.0-0.40.4-0.3-0.10.21.1-0.30.61.51.71.10.8
Baseline Anxiety0.91.12.61.3-1.3-0.8-1.61.6-0.1-1.60.70.50.00.60.4
Tail length0.10.51.30.4-0.4-0.4-1.00.90.1-0.90.80.31.10.50.4
Length with tail0.10.51.40.5-0.5-0.4-1.21.2-0.5-1.10.2-0.40.70.00.0
Length without tail0.10.30.9-0.80.80.90.5-0.50.20.5-0.4-0.20.3-0.1-0.1
Times rat made contact with spout0.30.31.2-0.20.21.10.5-0.5-0.10.5-0.9-0.4-0.4-0.5-0.5
Lifetime Intake0.20.20.4-0.40.40.20.6-0.60.50.6-0.20.20.10.50.6
Liver weight, left0.10.10.40.2-0.2-0.6-0.50.5-0.1-0.50.30.10.30.10.1
Liver weight, right0.40.71.2-0.80.80.80.6-0.60.80.71.10.71.00.80.8
Locomotor activity0.10.11.3-0.20.21.1-0.00.0-0.1-0.0-0.1-0.20.2-0.1-0.3
Locomotor testing distance0.10.21.10.0-0.01.0-0.20.2-0.4-0.1-0.1-0.4-0.3-0.4-0.5
Locomotor testing rearing0.40.92.7-1.21.21.61.0-1.00.61.10.80.60.60.50.4
Locomotion in novel chamber4.45.612.8-2.42.43.62.7-2.72.32.72.11.91.31.91.9
Locomotion in novel chamber post-restriction0.10.20.40.1-0.10.60.1-0.1-0.50.30.6-0.6-0.5-0.2-0.2
Fecal boli incidents, locomotor time 10.50.82.6-1.21.21.60.9-0.90.30.8-1.1-0.20.3-0.1-0.1
Change in fecal boli incidents, locomotor task0.90.92.91.3-1.3-1.7-0.90.9-0.5-0.80.9-0.1-0.7-0.1-0.2
Time >=10cm from walls, locomotor time 10.20.21.00.1-0.1-0.0-0.20.2-0.4-0.10.0-0.7-0.1-0.8-1.0
Bouts of movement, locomotor time 10.80.93.90.3-0.3-0.1-0.50.5-1.0-0.6-2.0-1.2-0.9-1.1-1.0
Total resting periods, locomotor time 11.41.65.60.5-0.50.1-0.60.5-1.5-0.6-2.4-1.8-1.4-1.6-1.4
Rest time, locomotor task time 10.50.62.1-0.10.10.90.3-0.3-0.80.3-1.5-1.1-1.0-0.9-0.8
Distance moved, locomotor task time 10.71.15.20.9-0.9-0.9-0.80.90.4-0.72.30.90.41.01.1
Vertical activity count, locomotor time 10.20.52.30.3-0.3-1.0-0.60.60.2-0.51.50.50.70.60.5
Time >=10cm from walls, locomotor time 20.20.30.8-0.10.1-0.0-0.00.0-0.50.0-0.7-0.8-0.6-0.9-0.9
Bouts of movement, locomotor time 22.23.66.81.3-1.3-1.2-0.90.9-2.3-0.8-2.3-2.4-2.4-2.5-2.6
Total resting periods, locomotor time 22.34.07.41.3-1.3-1.2-0.90.9-2.5-0.8-2.5-2.6-2.6-2.7-2.7
Rest time, locomotor task time 20.91.12.80.6-0.60.2-0.20.2-1.4-0.1-1.4-1.6-1.7-1.3-1.2
Distance moved, locomotor task time 20.80.92.5-0.20.20.00.0-0.01.3-0.01.61.41.01.41.4
Vertical activity count, locomotor time 20.20.20.7-0.40.40.20.2-0.20.60.10.40.50.90.50.4
Light reinforcement 10.20.40.60.7-0.7-0.1-0.80.8-0.7-0.7-0.5-0.5-0.8-0.6-0.6
Light reinforcement 21.72.69.11.2-1.20.3-1.01.0-1.8-1.1-3.0-1.8-2.0-1.8-1.7
Bone: marrow area4.610.014.8-3.83.83.23.5-3.53.33.42.32.82.92.52.5
Bone: maximum diameter5.19.512.6-3.53.53.62.8-2.83.22.82.82.93.22.92.9
Bone: maximum force0.61.12.7-1.21.21.71.3-1.30.91.30.60.50.80.50.5
Bone: maximum moment0.61.12.7-1.11.11.61.1-1.21.01.10.60.71.00.70.7
Mean time between licks in bursts0.30.81.61.0-1.0-1.2-1.11.10.1-1.10.90.60.70.70.7
Mean num. licks in bursts1.82.94.0-1.71.71.51.3-1.41.91.31.81.72.01.81.8
Cd content in liver1.71.93.91.3-1.3-1.1-1.51.5-1.3-1.7-2.0-1.1-0.8-1.2-1.2
Co content in liver2.42.77.32.1-2.1-1.6-2.62.6-0.5-2.7-0.00.30.60.60.5
Cu content in liver4.85.78.62.5-2.5-1.3-1.71.7-2.9-1.6-2.6-2.7-2.9-2.8-2.8
Fe content in liver2.12.63.31.7-1.7-1.6-1.41.4-1.8-1.4-1.8-1.7-1.5-1.7-1.7
K content in liver0.80.82.0-0.10.10.50.7-0.8-0.70.9-0.4-1.1-1.4-1.3-1.3
Mg content in liver0.70.72.10.1-0.10.30.5-0.5-0.80.6-0.8-1.1-1.4-1.3-1.2
Mn content in liver3.43.88.91.2-1.2-0.10.0-0.0-2.10.1-2.6-2.5-3.0-2.9-2.9
Na content in liver1.11.22.80.6-0.6-0.2-0.20.2-1.3-0.1-1.2-1.5-1.7-1.6-1.6
Rb content in liver0.10.10.80.2-0.20.90.1-0.10.1-0.0-0.7-0.10.0-0.2-0.2
Se content in liver17.020.128.14.2-4.2-3.3-3.53.5-5.3-3.4-4.9-5.2-5.1-5.2-5.2
Sr content in liver0.40.40.90.3-0.30.3-0.30.3-0.8-0.2-0.4-0.8-1.0-0.9-0.9
Zn content in liver1.92.13.71.2-1.2-0.5-1.01.0-1.7-0.9-1.6-1.7-1.9-1.8-1.8
Bone: minimum diameter6.612.015.3-3.53.53.02.8-2.83.92.73.83.83.93.83.8
Time in familiar zone, hab. session 10.20.20.3-0.50.50.30.4-0.40.50.40.20.50.60.60.6
Time in novel zone, hab. session 10.30.30.80.5-0.5-0.2-0.40.4-0.7-0.3-0.1-0.7-0.9-0.6-0.6
Total zone transitions, hab. session 10.10.20.40.0-0.00.20.3-0.3-0.40.4-0.3-0.6-0.6-0.5-0.4
Total locomotion distance, hab. session 11.62.23.81.4-1.4-1.0-0.90.9-1.7-0.9-1.9-1.9-1.6-1.8-1.7
Locomotion velocity, hab. session 12.73.95.72.1-2.1-1.6-1.51.5-2.2-1.4-2.3-2.4-2.0-2.2-2.1
Time in familiar zone, hab. session 20.70.71.90.9-0.9-1.2-1.21.3-0.1-1.40.00.40.50.40.4
Time in novel zone, hab. session 20.20.20.4-0.10.10.60.3-0.3-0.40.4-0.4-0.6-0.7-0.5-0.5
Total zone transitions, hab. session 20.60.72.20.9-0.9-1.5-0.90.9-0.9-0.8-0.3-0.7-0.7-0.6-0.5
Total locomotion distance, hab. session 21.51.93.91.6-1.6-2.0-1.51.5-1.3-1.5-1.4-1.1-0.8-1.0-1.0
Locomotion velocity, hab. session 21.41.94.01.5-1.5-2.0-1.31.3-1.4-1.3-1.3-1.3-1.1-1.2-1.2
Novel to familiar place preference ratio3.33.68.7-2.12.12.62.9-2.90.92.9-0.40.0-0.5-0.4-0.4
Novelty place preference3.43.79.1-2.12.12.63.0-3.00.93.0-0.30.1-0.5-0.3-0.3
Time in novel zone, NPP test3.23.58.6-2.12.12.52.9-2.91.02.9-0.20.2-0.4-0.3-0.3
Total zone transitions, NPP test0.60.91.51.1-1.1-1.2-1.11.1-1.0-1.0-0.6-0.9-0.7-0.6-0.6
Total locomotion distance, NPP test2.83.95.02.1-2.1-1.8-1.81.8-2.2-1.7-2.2-2.2-1.8-2.0-1.9
Locomotion velocity, NPP test2.33.34.21.9-1.9-1.7-1.61.6-2.0-1.6-2.0-2.0-1.7-1.8-1.8
Intraocular pressure0.30.40.80.9-0.9-0.5-0.60.6-0.4-0.7-0.5-0.3-0.6-0.4-0.5
Delta distance traveled before/after self-admin1.81.92.4-1.41.41.61.3-1.31.41.31.51.40.81.41.5
Delta ambulatory time before/after self-admin2.32.84.1-1.61.62.01.5-1.51.81.51.81.81.21.81.9
Parametrial fat weight0.61.33.21.2-1.2-1.5-1.81.8-0.9-1.70.0-0.60.2-0.4-0.3
Pavlov. Cond. lever latency0.10.10.40.1-0.1-0.0-0.30.30.2-0.40.30.50.60.60.6
Pavlov. Cond. magazine entry latency0.71.01.41.1-1.1-1.2-1.11.0-0.9-1.0-0.8-1.0-0.7-0.8-0.8
Pavlov. Cond. change in total contacts0.10.10.30.2-0.2-0.3-0.30.2-0.2-0.3-0.6-0.3-0.2-0.3-0.3
Pavlov. Cond. index score0.60.71.20.7-0.7-0.8-0.50.5-0.9-0.4-0.8-1.1-1.0-1.1-1.1
Pavlov. Cond. latency score0.40.50.80.6-0.6-0.7-0.40.4-0.8-0.3-0.5-0.9-0.9-0.9-0.9
Pavlov. Cond. lever contacts0.40.40.80.5-0.5-0.8-0.30.3-0.7-0.2-0.7-0.8-0.9-0.8-0.8
Pavlov. Cond. magazine entry number0.10.10.3-0.50.50.50.4-0.40.20.40.50.20.20.20.3
Pavlov. Cond. intertrial magazine entries0.30.31.60.3-0.3-0.4-0.20.2-0.4-0.3-1.3-0.5-0.4-0.7-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.71.10.7-0.7-0.9-0.50.5-0.9-0.4-0.9-1.1-1.0-1.0-1.0
Pavlov. Cond. response bias0.20.20.50.5-0.5-0.5-0.30.3-0.4-0.3-0.7-0.5-0.5-0.5-0.5
Pavlov. Cond. lever latency1.21.62.2-1.41.41.21.5-1.51.41.41.11.31.01.00.9
Pavlov. Cond. magazine entry latency0.50.62.70.6-0.6-0.4-0.70.7-0.6-0.8-1.7-0.9-0.6-0.7-0.8
Pavlov. Cond. change in total contacts0.30.51.00.9-0.9-0.7-1.01.0-0.7-1.0-0.3-0.5-0.3-0.3-0.3
Pavlov. Cond. index score1.01.42.01.2-1.2-1.1-1.21.2-1.2-1.2-1.4-1.3-0.9-1.0-1.0
Pavlov. Cond. latency score0.91.22.41.0-1.0-0.7-1.01.0-1.1-1.1-1.5-1.3-0.9-1.0-1.0
Pavlov. Cond. lever contacts1.41.92.91.6-1.6-1.6-1.71.7-1.4-1.7-1.0-1.2-0.9-0.9-0.9
Pavlov. Cond. magazine entry number2.32.84.7-1.81.81.41.7-1.71.61.82.21.71.31.51.5
Pavlov. Cond. intertrial magazine entries1.01.52.0-1.41.40.41.3-1.31.31.31.01.31.31.01.0
Pavlov. Cond. lever-magazine prob. diff.1.01.32.31.0-1.0-0.9-1.11.1-1.2-1.1-1.5-1.3-0.9-1.1-1.1
Pavlov. Cond. response bias1.41.92.71.6-1.6-1.5-1.61.6-1.4-1.6-1.2-1.3-0.9-1.0-0.9
Time in closed arm before self-admin0.40.52.8-0.80.81.70.8-0.80.20.7-0.7-0.1-0.0-0.1-0.1
Time in closed arm after self-admin0.20.20.70.3-0.3-0.0-0.70.7-0.2-0.8-0.30.10.00.20.1
Time in open arm before self-admin0.30.31.30.4-0.4-1.2-0.50.50.4-0.6-0.10.60.50.40.3
Time in open arm after self-admin0.30.41.3-0.50.5-0.10.9-0.9-0.01.10.8-0.2-0.3-0.2-0.1
Bone: periosteal estimation3.06.38.9-3.03.02.62.4-2.42.62.32.22.32.72.22.2
Bone: periosteal perimeter3.15.36.6-2.52.52.42.0-2.02.51.92.22.32.62.32.3
Bone: post-yield work0.81.22.0-1.21.21.01.4-1.41.21.40.70.91.00.70.7
Progressive ratio test 1 active lever presses0.10.10.3-0.30.30.00.5-0.5-0.20.6-0.3-0.4-0.2-0.3-0.2
Progressive ratio test 1 breakpoint0.10.10.3-0.10.1-0.20.3-0.3-0.30.4-0.4-0.6-0.4-0.4-0.4
Progressive ratio test 1 inactive lever presses0.30.41.0-0.50.50.81.0-1.00.40.9-0.50.0-0.3-0.00.1
Progressive ratio test 2 active lever presses0.70.81.8-0.70.71.31.3-1.30.21.3-1.2-0.5-0.5-0.4-0.3
Progressive ratio test 2 breakpoint0.70.81.7-0.60.61.21.3-1.30.21.2-1.3-0.5-0.5-0.3-0.3
Progressive ratio test 2 inactive lever presses0.40.71.5-0.40.40.61.2-1.20.11.2-1.2-0.5-0.9-0.5-0.4
Incentive Sensitization - Responses0.91.33.6-1.01.01.91.5-1.60.41.5-1.4-0.4-0.4-0.3-0.3
Incentive Sensitization - Breakpoint0.81.13.2-0.80.81.81.3-1.40.21.3-1.5-0.5-0.5-0.4-0.3
Sum of active levers in priming session hrs 5-60.10.10.60.1-0.1-0.8-0.40.4-0.2-0.5-0.4-0.20.1-0.3-0.4
Progressive ratio0.40.61.50.2-0.2-1.2-0.90.90.2-1.1-0.30.60.60.70.8
Food seeking constrained by brief footshock0.30.30.70.3-0.3-0.7-0.40.4-0.7-0.3-0.2-0.8-0.7-0.7-0.7
Seeking ratio, punishment vs. effort0.50.71.80.6-0.60.50.0-0.0-1.00.2-0.1-1.3-1.1-1.3-1.3
Retroperitoneal fat weight0.20.61.50.9-0.9-0.7-1.11.10.2-1.20.10.60.60.70.7
Reaction time number correct2.03.95.6-2.42.42.42.2-2.21.92.21.51.61.71.31.3
Reaction time mean minus median0.10.31.00.2-0.2-0.4-0.40.40.6-0.50.30.71.00.90.8
Reaction time mean minus median AUC0.10.41.40.1-0.1-0.3-0.40.40.7-0.50.20.81.20.80.8
Reaction time num false alarms0.20.31.30.0-0.0-1.1-0.60.6-0.1-0.50.70.20.50.30.3
Reaction time num false alarms AUC0.20.31.40.1-0.1-1.2-0.60.60.0-0.50.90.30.60.40.5
Reaction time trials correct on left2.03.95.6-2.42.42.42.2-2.21.92.21.51.61.71.31.3
Reaction time trials on left2.03.85.5-2.32.32.32.2-2.21.92.11.51.61.81.31.3
Reaction time mean1.01.63.51.5-1.5-1.7-1.81.7-0.8-1.9-1.0-0.5-0.2-0.2-0.2
Reaction time mean AUC1.11.73.91.6-1.6-2.0-1.71.7-0.9-1.8-0.9-0.6-0.4-0.4-0.4
Median of all reaction times1.21.73.41.5-1.5-1.5-1.71.7-1.0-1.9-1.4-0.7-0.5-0.5-0.5
Reaction time omissions0.30.51.8-0.40.40.2-0.30.31.0-0.5-0.31.01.40.90.8
Reaction time false alarm rate1.01.34.61.2-1.2-2.1-1.61.6-0.9-1.50.1-0.5-0.3-0.2-0.2
Reaction time premature initiation rate0.60.91.71.3-1.3-0.9-1.21.2-0.7-1.1-0.1-0.6-1.0-0.4-0.3
Reaction time premature initiations0.00.10.20.1-0.10.3-0.10.10.2-0.10.50.20.00.30.3
Std. dev. reaction times0.51.02.11.0-1.0-1.5-1.31.30.3-1.40.10.60.90.80.8
Reaction time trials completed2.03.85.5-2.32.32.32.2-2.21.92.11.51.61.81.31.3
Reaction time trials AUC1.83.55.2-2.22.22.32.1-2.11.82.11.41.61.71.21.2
Run reversals in cocaine runway, females0.50.51.40.5-0.5-0.2-0.10.1-0.8-0.1-1.2-0.8-1.0-1.0-0.7
Run reversals in cocaine runway, males3.33.34.52.1-2.1-2.1-1.91.9-2.1-1.8-1.2-1.9-1.6-1.5-1.4
Latency to leave start box in cocaine runway2.73.16.3-1.31.30.90.9-0.92.20.71.82.52.32.42.3
Latency to leave start box in cocaine runway, F3.84.37.1-1.81.81.31.5-1.52.41.42.52.72.52.52.4
Latency to leave start box in cocaine runway, M0.40.30.9-0.20.20.0-0.10.10.8-0.30.11.00.81.00.9
Std. dev. time between licks in bursts1.21.63.41.5-1.5-1.4-1.81.8-1.0-1.8-0.9-0.6-0.6-0.7-0.7
Total sessions with >9 infusions0.10.20.50.7-0.7-0.4-0.30.3-0.4-0.20.3-0.2-0.50.00.3
Short access day 1 total inactive lever presses1.31.83.3-1.61.61.31.8-1.81.21.70.31.00.60.81.0
Short access day 10 total inactive lever presses0.10.21.1-0.20.20.5-0.30.3-0.3-0.4-1.0-0.3-0.2-0.5-0.4
Short access day 1 total infusions0.50.61.50.9-0.9-0.6-0.40.4-0.9-0.4-1.2-1.0-1.1-0.6-0.5
Short access day 10 total infusions1.01.32.11.5-1.5-1.4-1.21.2-1.1-1.2-1.1-0.9-1.0-0.7-0.4
Short access total infusions0.10.10.40.1-0.10.20.2-0.2-0.30.2-0.6-0.4-0.4-0.10.2
Short access day 1 locomotion0.30.30.9-0.10.10.30.9-0.90.41.00.70.4-0.40.50.7
Short access day 10 total locomotion0.20.41.20.2-0.2-0.60.3-0.3-0.50.3-1.1-0.8-0.8-0.8-0.7
Short access total locomotion0.10.10.60.3-0.3-0.10.3-0.3-0.30.3-0.2-0.3-0.8-0.2-0.0
One hour access (0.3 mA shock)1.72.05.1-1.51.51.52.2-2.31.12.2-0.30.30.00.50.6
Compulsive drug intake0.91.12.1-0.90.91.00.8-0.81.40.71.11.40.71.41.3
One hour access (shock baseline)0.10.20.5-0.30.3-0.30.7-0.70.10.7-0.2-0.20.00.10.2
Social response proportion3.03.45.9-2.42.41.52.3-2.31.82.41.41.40.91.00.9
Social responses1.01.33.3-1.31.30.11.2-1.11.11.31.81.00.31.01.0
Social time0.10.21.30.0-0.0-0.80.0-0.0-0.20.21.1-0.0-0.40.00.0
Soleus weight1.23.76.1-2.32.32.51.8-1.82.11.60.71.82.31.61.5
Bone: stiffness0.61.12.1-1.21.21.41.1-1.10.91.21.00.61.00.60.6
Tibialis anterior weight0.62.13.7-1.91.91.61.5-1.51.41.40.61.11.61.01.0
Time to tail flick, vehicle, before self-admin0.40.41.00.3-0.30.20.1-0.1-0.80.2-0.8-0.8-1.0-0.9-0.8
Time to tail flick, vehicle, after self-admin0.30.40.8-0.50.50.60.8-0.80.50.90.80.50.20.60.6
Time to tail flick, test, before self-admin0.60.61.3-0.80.81.01.1-1.10.71.10.20.40.00.40.5
Time to tail flick, test, after self-admin0.10.10.4-0.20.20.40.2-0.2-0.10.1-0.6-0.1-0.3-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.60.60.9-0.80.80.60.9-0.90.80.90.40.60.70.70.6
Delta time to tail flick, test, before/after SA0.40.41.00.5-0.5-0.1-0.60.6-0.7-0.7-1.0-0.6-0.5-0.8-0.9
Tibia length0.10.30.80.7-0.7-0.8-0.90.9-0.3-0.90.3-0.0-0.20.20.2
Ambulatory time before self-admin0.40.51.3-1.11.10.90.9-0.90.20.90.20.00.60.30.4
Ambulatory time after self-admin3.94.611.1-2.82.83.32.5-2.51.42.61.10.91.01.31.5
Bone: tissue strength0.20.20.5-0.30.30.00.3-0.30.70.20.30.70.70.60.6
Total heroin consumption0.20.20.70.1-0.1-0.3-0.00.0-0.4-0.0-0.7-0.7-0.4-0.8-0.8
Bone: trabecular number1.42.34.3-2.12.12.01.8-1.81.41.70.31.11.10.80.7
Bone: trabecular spacing1.41.83.81.9-1.9-1.8-1.81.8-0.9-1.8-0.2-0.5-0.5-0.1-0.1
Bone: trabecular thickness1.61.92.7-1.41.41.71.3-1.31.51.31.11.41.41.41.4
Bone: trabecular tissue density1.01.53.9-1.31.32.01.1-1.01.11.11.51.10.91.11.1
Water consumed over 24 hours0.50.71.2-0.60.61.11.0-1.0-0.21.0-1.1-0.7-0.8-0.8-0.8
Number of responses in last shaping day0.20.20.50.7-0.7-0.7-0.40.4-0.0-0.40.30.2-0.20.30.5