Hub : Genes

Hectd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Hectd2 0.2 0.15 3.9e-03 0.05 0.03 0.04 0.05 4.1e-05 2.8e-03 7.6e-04 7.9e-05
2 NAcc intron excision ratio chr1_243740486_243741401 0.02 0.02 6.9e-03 0.01 0.01 0 0 2.1e-02 3.2e-02 1.2e-01 5.1e-02
3 NAcc intron excision ratio chr1_243744524_243746360 0.02 0.02 6.8e-03 0.01 0.01 0 0.01 3.4e-03 2.6e-02 6.8e-02 2.1e-02
4 IC gene expression Hectd2 0.27 0.12 1.4e-05 0.12 0.11 0.05 0.1 9.4e-06 2.6e-05 3.0e-03 5.8e-05
5 PL gene expression Hectd2 0.11 0.05 6.3e-12 0.1 0.1 0.11 0.1 1.9e-11 1.7e-11 4.2e-12 1.5e-11
6 IL gene expression Hectd2 0.35 0.13 1.6e-05 0.02 0.17 0.16 0.13 9.9e-02 6.4e-05 9.8e-05 4.7e-04
7 NAcc mRNA stability Hectd2 0.03 0.02 1.8e-04 0.03 0.03 0.01 0.03 6.5e-06 4.8e-05 2.7e-03 6.6e-05
8 BLA gene expression Hectd2 0.16 0.07 5.8e-07 0.1 0.11 0.06 0.09 6.8e-06 3.1e-06 2.9e-04 2.0e-05
9 Adipose gene expression Hectd2 0.1 0.05 9.9e-10 0.06 0.08 0.07 0.07 9.2e-07 7.8e-09 4.4e-08 5.4e-08
10 pVTA gene expression Hectd2 0.09 0.05 5.6e-05 0.06 0.06 0.05 0.06 2.0e-05 1.7e-05 1.0e-04 1.1e-05
11 NAcc gene expression Hectd2 0.06 0.03 1.5e-07 0.03 0.05 0.04 0.04 1.0e-04 9.4e-08 8.1e-07 7.5e-07
12 Liver gene expression Hectd2 0.06 0.04 8.5e-05 0.04 0.03 0.01 0.03 6.3e-05 5.5e-04 1.1e-02 6.3e-04
13 Brain gene expression Hectd2 0.14 0.06 3.9e-11 0.1 0.12 0.1 0.11 1.2e-09 3.8e-11 8.9e-10 3.6e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density2.54.713.53.5-3.73.72.10.4-0.21.90.90.51.20.1-2.91.7
Area under the delay curve0.71.04.72.20.8-0.8-0.00.3-1.3-0.7-1.4-1.3-0.6-0.50.6-0.9
BMI with tail0.10.20.5-0.2-0.70.70.00.00.4-0.20.60.50.70.3-0.40.6
BMI without tail0.21.14.11.1-0.10.10.11.2-1.1-2.0-1.1-1.1-0.7-0.81.1-1.0
Body weight1.87.716.24.0-2.72.72.33.5-3.1-3.3-2.6-2.9-1.8-2.41.8-2.0
Weight adjusted by age0.20.61.60.90.4-0.4-0.4-1.00.41.20.70.70.90.5-1.30.9
Bone surface1.52.99.13.0-2.82.81.30.2-0.11.40.80.51.10.4-2.21.4
Bone volume1.93.712.03.5-3.53.52.10.9-0.81.10.2-0.10.4-0.4-1.90.9
Breakpoint value in progressive ratio session0.61.11.71.2-0.40.41.01.3-1.3-1.1-1.1-1.3-0.7-1.20.9-0.9
Number of licking bursts0.31.03.0-1.11.7-1.7-1.0-0.1-0.5-1.5-0.6-1.0-0.4-0.50.9-0.6
Context. condit. distance diff. score1.51.84.60.8-1.81.82.11.6-1.2-0.4-1.0-0.7-1.4-1.50.7-1.0
Locomotion velocity, session 13.03.47.1-2.12.0-2.0-2.7-2.22.00.81.81.61.71.9-1.11.6
Locomotion distance, session 10.30.40.7-0.90.8-0.8-0.8-0.60.60.40.60.50.50.4-0.30.5
Locomotion velocity, session 20.50.62.2-1.51.0-1.0-1.2-0.80.80.20.60.60.30.6-0.10.4
Locomotion distance, session 20.40.61.2-0.80.7-0.7-0.10.6-0.6-1.1-0.7-0.8-0.9-0.81.0-0.8
Locomotion velocity, session 30.40.40.70.2-0.60.60.60.8-0.7-0.5-0.6-0.6-0.8-0.80.7-0.6
Locomotion distance, session 31.72.03.40.5-0.90.91.61.8-1.5-0.9-1.4-1.4-1.9-1.81.4-1.6
Stereotopy head waving bouts, day 30.91.11.80.0-0.00.0-1.0-1.11.20.81.11.41.31.4-1.11.2
Stereotopy head waving duration, day 30.70.91.70.50.1-0.1-0.9-1.11.00.70.91.11.31.3-1.11.1
Locomotion velocity, session 71.31.42.71.2-0.60.61.71.2-1.4-0.3-1.4-1.2-1.4-1.50.8-1.3
Locomotion distance, session 71.01.32.71.4-0.90.91.61.2-1.3-0.2-1.2-1.1-1.4-1.30.5-1.1
Stereotopy head waving bouts, day 70.20.20.6-0.40.3-0.3-0.8-0.50.6-0.10.50.50.40.6-0.20.4
Stereotopy head waving duration, day 70.40.51.0-0.1-0.00.0-0.9-0.70.80.30.80.81.01.0-0.60.8
Locomotion velocity, session 80.10.10.5-0.2-0.70.70.50.10.20.40.20.2-0.0-0.1-0.40.1
Locomotion distance, session 80.81.12.3-0.4-0.60.61.51.3-1.0-0.6-0.9-0.7-1.5-1.51.0-1.1
Degree of sensitization distance0.10.10.50.70.4-0.40.1-0.2-0.20.0-0.3-0.2-0.10.0-0.1-0.1
Degree of sensitization stereotypy0.00.00.10.1-0.10.1-0.4-0.10.2-0.10.30.20.30.4-0.10.3
Conditioned locomotion0.20.20.90.2-0.70.70.90.4-0.40.4-0.1-0.3-0.4-0.6-0.1-0.0
Cocaine response after cond. corrected0.10.11.01.0-0.00.0-0.2-0.4-0.00.30.10.20.30.2-0.40.2
Cocaine response after cond. not corrected0.40.63.11.8-0.30.30.50.6-1.0-0.5-0.9-0.8-0.7-0.70.5-0.7
Cocaine response before conditioning1.51.83.11.30.0-0.00.71.5-1.5-1.5-1.7-1.7-1.4-1.11.7-1.6
Saline control response0.81.15.92.40.0-0.00.90.5-1.30.0-1.4-0.9-1.1-0.90.4-1.1
Bone: connectivity density2.13.38.22.2-2.32.30.9-0.60.82.11.61.31.81.1-2.92.1
Bone: cortical apparent density0.71.23.1-0.51.8-1.8-1.5-1.30.90.40.61.00.71.1-0.30.6
Bone: cortical area3.15.09.63.1-2.72.72.72.6-2.4-1.3-1.9-2.1-1.8-2.10.8-1.5
Bone: cortical porosity0.10.10.3-0.60.4-0.4-0.1-0.30.40.50.20.30.20.20.10.1
Bone: cortical porosity0.00.00.1-0.1-0.10.10.20.1-0.10.0-0.1-0.1-0.1-0.20.2-0.2
Bone: cortical thickness2.23.65.82.3-1.01.01.62.1-2.4-2.0-2.2-2.3-1.8-2.01.5-1.9
Bone: cortical thickness0.50.61.00.60.6-0.60.00.6-1.0-0.9-1.0-1.0-0.8-0.90.9-0.9
Bone: cortical tissue density0.81.33.5-0.71.9-1.9-1.6-1.41.10.50.71.10.81.2-0.40.7
Condit. Reinf. active minus inactive responses0.60.71.5-0.20.8-0.8-0.30.3-0.7-1.1-0.9-0.8-1.0-0.71.2-1.0
Condit. Reinf. active-inactive response ratio0.70.72.1-1.41.0-1.0-1.3-1.00.80.20.60.60.40.70.10.3
Condit. Reinf. active responses1.31.62.81.2-0.10.10.91.2-1.6-1.2-1.7-1.4-1.6-1.41.3-1.6
Condit. Reinf. inactive responses1.82.46.42.5-1.11.11.71.7-1.9-0.9-1.7-1.5-1.4-1.60.6-1.3
Incentive salience index mean1.62.13.90.20.9-0.90.11.0-1.5-1.9-1.8-1.7-1.8-1.42.0-1.9
Condit. Reinf. lever presses1.52.24.60.11.2-1.2-0.20.9-1.4-2.2-1.8-1.5-1.8-1.32.1-1.9
Condit. Reinf. active minus inactive responses1.31.93.31.0-0.60.61.41.6-1.7-1.4-1.6-1.5-1.7-1.81.0-1.5
Condit. Reinf. active-inactive response ratio0.30.40.90.30.2-0.20.50.6-0.9-0.8-0.8-0.7-0.9-1.00.5-0.7
Condit. Reinf. active responses1.82.64.92.2-1.71.71.81.8-1.9-0.9-1.5-1.5-1.5-1.80.6-1.3
Condit. Reinf. inactive responses1.01.54.42.1-1.81.81.31.1-1.2-0.3-0.9-1.0-0.7-0.90.1-0.6
Condit. Reinf. lever presses0.10.10.40.6-0.60.60.20.1-0.40.2-0.2-0.3-0.3-0.4-0.3-0.1
Condit. Reinf. lever reinforcers received1.31.93.41.8-1.31.31.51.5-1.7-0.9-1.4-1.3-1.3-1.60.6-1.1
Conditioned reinforcement - actives0.20.73.41.9-1.31.30.60.5-0.20.50.1-0.10.80.4-0.50.3
Conditioned reinforcement - inactives0.30.83.71.9-1.11.10.5-0.00.31.00.40.60.90.8-0.90.7
Conditioned locomotion0.81.22.50.8-1.21.20.0-0.40.91.21.21.11.61.2-1.21.3
Patch foraging indifference point 0 sec0.20.74.50.7-0.30.3-0.61.0-0.7-2.1-0.6-1.10.2-0.10.7-0.3
Patch foraging indifference point AUC0.51.33.51.81.0-1.0-0.40.7-1.0-1.9-1.5-1.1-0.7-0.21.0-1.2
Delay disc. indifference point, 0s delay1.92.24.52.10.3-0.31.51.4-1.9-1.0-1.9-1.7-1.5-1.61.0-1.5
Delay disc. indifference point, 16s delay0.30.54.72.2-0.30.30.00.1-0.8-0.0-0.7-0.7-0.0-0.0-0.2-0.2
Delay disc. indifference point, 2s delay0.30.31.61.30.8-0.8-0.4-0.6-0.10.5-0.10.10.40.3-0.50.3
Delay disc. indifference point, 24s delay1.21.93.81.60.9-0.9-0.00.5-1.5-1.8-2.0-1.7-1.4-0.81.5-1.7
Delay disc. indifference point, 4s delay1.51.65.22.30.3-0.30.70.9-1.7-0.9-1.7-1.6-1.1-1.10.9-1.3
Delay disc. indifference point, 8s delay0.50.93.01.31.7-1.7-1.2-0.5-0.6-0.5-0.9-0.8-0.10.20.5-0.5
Indifference point function ln k0.20.61.9-0.9-1.41.40.90.40.10.80.60.3-0.1-0.6-0.30.4
Indifference point function log k0.20.61.9-0.9-1.41.40.90.40.10.80.60.3-0.1-0.6-0.30.4
Patch foraging total patch changes 0 sec0.20.74.20.8-0.40.4-0.61.0-0.7-2.1-0.5-1.10.2-0.10.7-0.3
Patch foraging total patch changes 12 sec0.50.61.80.91.2-1.2-1.3-0.2-0.1-1.3-0.4-0.30.40.70.3-0.2
Patch foraging total patch changes 18 sec0.30.62.91.30.6-0.6-0.50.6-0.7-1.7-0.8-0.8-0.1-0.10.5-0.5
Patch foraging total patch changes 24 sec0.62.18.21.50.2-0.20.01.6-1.6-2.9-1.7-1.9-0.9-0.91.3-1.3
Patch foraging total patch changes 6 sec0.50.94.01.20.8-0.8-1.30.3-0.6-2.0-0.8-1.00.20.40.8-0.6
Patch foraging time to switch 0 sec0.31.14.9-2.21.3-1.3-1.0-1.20.90.80.90.60.50.5-0.40.6
Patch foraging water rate 0 sec0.10.41.20.7-0.80.80.71.1-0.5-0.7-0.5-0.3-0.4-0.50.4-0.5
Patch foraging water rate 12 sec0.10.40.90.5-1.01.00.60.8-0.6-0.5-0.3-0.70.0-0.60.6-0.3
Patch foraging water rate 18 sec0.30.71.50.4-1.21.21.11.2-0.7-0.5-0.5-0.8-0.5-0.80.7-0.6
Patch foraging water rate 24 sec2.02.84.42.1-1.61.61.92.1-1.9-1.4-1.6-1.7-1.4-1.70.9-1.5
Patch foraging water rate 6 sec0.10.20.3-0.3-0.40.4-0.30.00.5-0.50.60.50.60.4-0.50.6
Seeking ratio, delayed vs. immediate footshock0.20.31.2-1.10.1-0.10.40.5-0.1-0.9-0.2-0.1-0.8-0.40.4-0.4
Distance traveled before self-admin0.10.20.5-0.60.7-0.7-0.10.2-0.2-0.3-0.4-0.1-0.7-0.40.6-0.5
Distance traveled after self-admin1.42.55.30.80.1-0.1-0.6-1.81.52.21.62.01.71.7-2.31.9
Extensor digitorum longus weight1.14.57.31.5-1.01.02.62.6-2.4-1.8-2.4-2.1-2.7-2.41.7-2.3
Bone: elastic displacement4.45.610.6-3.32.2-2.2-2.6-2.82.71.82.42.52.12.2-1.22.0
Bone: elastic work3.95.17.2-2.71.6-1.6-2.1-2.72.72.12.52.72.22.3-1.62.2
Bone: endosteal estimation1.33.311.92.7-3.43.42.21.1-0.51.10.30.20.2-0.3-1.70.8
Bone: endosteal perimeter1.33.111.61.7-3.43.42.31.0-0.11.50.80.40.6-0.3-1.91.1
Epididymis fat weight0.31.44.41.9-2.12.11.51.1-0.7-0.5-0.1-0.10.1-0.6-0.70.2
Delta time in closed arm before/after self-admin0.50.52.1-1.50.5-0.5-0.50.3-0.1-1.1-0.3-0.5-0.4-0.31.1-0.6
Delta time in open arm before/after self-admin0.30.41.41.20.6-0.6-0.1-0.70.20.90.20.70.20.4-0.90.5
Diff in mean of infusions in LGA sessions0.10.30.7-0.4-0.70.70.70.8-0.2-0.3-0.1-0.2-0.3-0.60.4-0.2
Delay discount exponential model param0.81.14.6-2.2-0.70.70.0-0.31.40.81.41.40.70.5-0.71.0
Extinction: sum of active levers before priming0.71.11.50.1-0.70.71.01.2-1.1-1.0-1.1-1.2-1.2-1.21.2-1.2
Active lever presses in extinction session 60.80.82.81.7-0.50.51.60.7-1.10.0-0.8-0.7-0.6-1.20.1-0.6
Bone: final force1.11.83.61.9-1.91.91.51.6-1.4-0.9-1.0-1.2-0.9-1.10.4-0.7
Bone: final moment0.71.13.31.7-1.81.81.11.2-0.9-0.4-0.5-0.7-0.4-0.6-0.1-0.1
Food consumed during 24 hour testing period0.20.31.50.0-0.30.3-0.10.7-0.5-1.2-0.5-0.7-0.5-0.40.3-0.5
Glucose0.10.21.1-1.1-0.20.20.20.40.1-0.7-0.0-0.1-0.2-0.20.4-0.2
Heart weight0.61.02.80.4-0.50.5-1.3-0.71.1-0.31.10.91.41.7-0.81.2
Delay discount hyperbolic model param0.60.83.8-1.9-0.80.80.2-0.11.10.61.21.10.40.3-0.50.8
Intermittent access intake day 1-15 change0.10.83.40.3-1.81.80.70.60.30.10.70.21.10.4-0.40.7
Intermittent access intake escalation0.10.73.40.2-1.81.81.00.70.10.00.50.20.80.2-0.40.5
Intermittent access intake escalation 20.20.31.1-1.1-0.90.90.50.70.4-0.30.50.30.50.00.00.2
Intermitt. access day 1 inactive lever presses0.00.51.20.71.1-1.1-1.0-1.00.40.60.20.70.30.7-0.50.4
Intermitt. access day 15 inactive lever presses0.31.94.62.1-1.21.20.2-0.60.81.71.11.21.61.3-2.01.5
Intermitt. access escalation Index0.10.30.80.10.6-0.60.1-0.1-0.3-0.4-0.7-0.3-0.6-0.10.9-0.8
Intermittent access day 1 total infusions0.20.73.21.8-1.31.30.90.4-0.20.60.10.10.60.1-0.60.4
Intermittent access day 15 total infusions0.81.97.72.0-2.82.81.71.1-0.30.40.2-0.00.80.1-0.50.4
Intermittent access terminal intake (last 3 days)0.71.34.91.1-2.22.21.10.60.40.60.70.61.10.5-0.80.8
Intermittent access total infusions0.91.04.01.3-2.02.01.40.7-0.00.40.30.30.70.2-0.60.5
Intermittent access day 1 locomotion0.30.52.11.5-1.31.30.80.6-0.40.4-0.1-0.10.2-0.2-0.10.1
Intermittent access day 15 total locomotion0.41.53.80.5-2.02.00.60.10.81.01.31.11.50.8-1.41.4
Intermittent access total locomotion0.80.92.80.8-1.71.70.90.30.40.80.80.81.10.4-1.00.9
Intermittent access standard deviation0.10.73.21.0-1.81.81.00.6-0.20.30.2-0.00.30.0-0.40.3
Left kidney weight0.54.06.62.2-2.12.11.72.6-2.2-2.5-1.8-2.2-1.3-1.71.5-1.5
Right kidney weight0.74.712.81.9-1.51.51.32.9-2.3-3.6-2.1-2.7-1.6-1.82.0-1.9
Cocaine induced anxiety0.10.32.01.4-0.10.10.80.1-0.50.3-0.4-0.2-0.2-0.3-0.3-0.2
Post-drug Anxiety0.60.71.91.0-0.60.60.2-0.80.51.40.70.70.80.7-1.40.9
Baseline Anxiety0.71.22.1-0.6-0.90.9-0.4-0.91.21.51.41.21.00.9-1.41.3
Tail length1.79.218.54.3-1.41.42.33.6-3.7-3.6-3.5-3.6-2.7-2.82.2-2.9
Length with tail2.912.836.36.0-3.03.03.14.1-4.3-3.2-3.7-4.1-2.6-3.12.0-2.8
Length without tail1.37.020.24.5-3.73.73.12.8-2.7-0.9-1.9-2.3-1.3-2.10.5-1.2
Times rat made contact with spout0.70.92.71.60.4-0.40.70.7-1.2-0.7-1.2-1.0-0.9-1.00.5-0.9
Lifetime Intake0.91.13.91.4-2.02.01.20.50.10.60.50.31.00.3-0.70.6
Liver weight, left0.71.21.91.1-1.41.41.21.4-1.2-0.7-0.9-1.1-0.9-1.20.4-0.7
Liver weight, right0.71.35.12.3-1.81.81.21.3-0.8-0.7-0.4-0.50.2-0.4-0.2-0.0
Locomotor activity0.20.41.0-0.90.9-0.9-1.0-0.50.5-0.30.40.30.30.2-0.10.4
Locomotor testing distance0.30.82.3-1.11.3-1.3-1.5-0.90.7-0.30.70.40.80.6-0.20.6
Locomotor testing rearing0.10.20.70.0-0.00.00.60.5-0.5-0.5-0.4-0.5-0.5-0.80.4-0.5
Locomotion in novel chamber0.50.61.2-1.1-1.01.01.0-0.00.51.00.90.90.1-0.3-0.90.7
Locomotion in novel chamber post-restriction0.92.75.31.8-1.71.72.31.9-1.8-0.6-1.5-1.4-1.5-1.90.6-1.4
Fecal boli incidents, locomotor time 10.10.10.70.0-0.10.10.80.5-0.1-0.3-0.4-0.0-0.3-0.20.4-0.5
Change in fecal boli incidents, locomotor task0.20.20.40.20.4-0.4-0.30.2-0.4-0.5-0.4-0.6-0.3-0.30.6-0.4
Time >=10cm from walls, locomotor time 13.44.27.72.0-2.02.02.82.3-2.3-1.0-2.1-2.1-2.3-2.31.0-1.9
Bouts of movement, locomotor time 10.20.31.30.1-0.30.30.60.7-0.5-1.1-0.2-0.70.0-0.70.4-0.2
Total resting periods, locomotor time 10.40.51.10.8-0.40.40.80.8-0.8-1.1-0.5-0.9-0.0-0.80.5-0.3
Rest time, locomotor task time 10.40.61.8-0.20.8-0.8-0.7-0.90.80.30.80.71.30.9-0.40.8
Distance moved, locomotor task time 10.72.04.61.1-0.00.00.81.3-1.7-1.2-1.9-1.6-2.1-1.51.4-1.8
Vertical activity count, locomotor time 10.00.30.7-0.2-0.80.80.40.7-0.5-0.1-0.5-0.6-0.8-0.60.2-0.5
Time >=10cm from walls, locomotor time 20.92.44.52.1-0.10.11.31.5-1.9-1.5-2.1-1.8-1.7-1.41.2-1.8
Bouts of movement, locomotor time 20.20.72.9-0.51.7-1.7-1.0-0.3-0.0-0.9-0.3-0.30.00.10.8-0.4
Total resting periods, locomotor time 20.20.82.8-0.61.7-1.7-0.8-0.2-0.2-1.1-0.5-0.5-0.1-0.11.0-0.5
Rest time, locomotor task time 20.20.40.9-0.50.2-0.20.50.6-0.6-0.8-0.5-0.9-0.3-0.90.7-0.5
Distance moved, locomotor task time 20.81.02.41.2-0.20.20.81.0-1.1-0.9-1.4-0.9-1.5-0.90.9-1.3
Vertical activity count, locomotor time 20.00.10.50.20.4-0.4-0.6-0.20.30.1-0.10.30.10.70.0-0.1
Light reinforcement 10.10.61.70.4-0.00.0-0.4-0.60.60.70.90.71.30.6-1.31.3
Light reinforcement 22.04.57.7-1.52.5-2.5-2.6-2.82.11.31.92.02.22.2-1.51.9
Bone: marrow area1.43.512.52.8-3.53.52.21.1-0.41.20.40.30.3-0.3-1.80.9
Bone: maximum diameter2.75.519.53.3-4.44.43.31.9-1.21.0-0.1-0.4-0.3-1.2-1.60.4
Bone: maximum force1.01.96.42.3-2.52.51.61.4-1.0-0.2-0.4-0.7-0.4-0.7-0.4-0.0
Bone: maximum moment0.81.55.92.1-2.42.41.21.0-0.50.20.0-0.30.1-0.2-0.80.4
Mean time between licks in bursts0.31.64.6-2.11.1-1.1-1.9-1.51.40.41.11.00.91.4-0.40.8
Mean num. licks in bursts0.30.83.31.8-1.31.31.30.5-0.21.0-0.10.4-0.2-0.1-0.50.0
Cd content in liver1.01.23.3-1.81.0-1.0-1.8-1.11.20.10.90.80.71.30.10.6
Co content in liver2.12.44.3-1.00.8-0.8-1.8-2.11.91.51.61.91.62.1-0.91.5
Cu content in liver3.23.86.5-0.21.6-1.6-2.5-2.61.81.81.81.62.42.3-1.92.0
Fe content in liver0.50.62.3-1.01.5-1.5-1.1-0.30.2-0.60.0-0.10.10.20.4-0.1
K content in liver0.30.31.3-0.41.1-1.10.2-0.1-0.3-0.0-0.5-0.3-0.6-0.40.6-0.6
Mg content in liver0.20.20.9-0.31.0-1.0-0.6-0.70.30.30.10.30.10.20.10.1
Mn content in liver0.50.51.5-0.81.2-1.2-1.1-0.80.6-0.00.40.30.50.7-0.10.3
Na content in liver0.70.82.1-0.51.5-1.5-0.1-0.1-0.6-0.5-0.9-0.7-1.0-0.71.1-1.0
Rb content in liver0.10.20.30.5-0.30.30.40.5-0.5-0.4-0.3-0.5-0.3-0.5-0.1-0.1
Se content in liver8.610.132.2-4.25.7-5.7-5.1-3.02.1-1.01.00.91.22.20.90.5
Sr content in liver3.63.24.9-1.00.4-0.4-1.6-2.12.11.92.12.22.02.1-1.82.0
Zn content in liver2.42.811.2-2.43.3-3.3-2.0-1.10.6-0.7-0.20.1-0.20.41.2-0.6
Bone: minimum diameter2.85.417.72.8-4.24.23.32.6-1.7-0.4-0.9-1.2-1.1-1.6-0.2-0.6
Time in familiar zone, hab. session 10.30.41.00.3-0.20.2-0.3-0.60.61.00.70.60.70.6-0.80.7
Time in novel zone, hab. session 10.30.31.1-1.10.8-0.8-0.30.1-0.0-0.8-0.2-0.2-0.2-0.10.6-0.3
Total zone transitions, hab. session 10.10.10.30.20.1-0.1-0.0-0.20.10.60.30.20.20.0-0.50.4
Total locomotion distance, hab. session 10.30.41.6-1.01.3-1.3-0.4-0.40.10.30.0-0.0-0.2-0.30.3-0.1
Locomotion velocity, hab. session 10.40.62.3-1.11.5-1.5-0.4-0.2-0.1-0.0-0.3-0.1-0.6-0.50.7-0.4
Time in familiar zone, hab. session 20.40.51.0-0.40.4-0.4-1.0-1.00.80.40.70.70.60.9-0.60.7
Time in novel zone, hab. session 20.00.00.1-0.1-0.00.00.20.20.10.00.10.10.20.0-0.10.1
Total zone transitions, hab. session 20.10.10.8-0.30.5-0.5-0.9-0.20.1-0.30.1-0.10.10.10.20.1
Total locomotion distance, hab. session 20.30.42.0-1.40.9-0.9-0.8-0.30.3-0.20.20.1-0.1-0.10.3-0.0
Locomotion velocity, hab. session 20.30.41.8-1.41.0-1.0-0.5-0.1-0.0-0.5-0.1-0.2-0.4-0.40.7-0.3
Novel to familiar place preference ratio0.20.31.41.2-0.50.50.80.4-0.30.1-0.0-0.10.4-0.2-0.50.3
Novelty place preference0.20.31.11.0-0.60.60.80.3-0.10.20.20.10.5-0.0-0.70.5
Time in novel zone, NPP test0.10.20.50.6-0.40.40.70.3-0.00.20.30.10.50.0-0.70.5
Total zone transitions, NPP test0.30.50.7-0.50.8-0.8-0.40.3-0.6-0.8-0.7-0.8-0.8-0.70.9-0.8
Total locomotion distance, NPP test0.50.72.7-1.11.6-1.6-0.8-0.1-0.2-0.8-0.4-0.3-0.5-0.40.7-0.6
Locomotion velocity, NPP test0.60.92.3-0.51.5-1.5-0.50.2-0.6-1.1-0.9-0.7-0.8-0.71.0-1.0
Intraocular pressure0.10.20.50.4-0.70.70.10.5-0.1-0.70.2-0.00.2-0.0-0.70.5
Delta distance traveled before/after self-admin1.81.94.21.6-1.51.50.5-0.80.81.81.21.31.61.1-2.11.5
Delta ambulatory time before/after self-admin1.32.35.62.4-1.71.70.7-0.80.81.81.11.31.51.2-2.11.5
Parametrial fat weight1.84.28.60.70.7-0.70.42.0-2.2-2.9-2.5-2.5-2.2-1.92.9-2.5
Pavlov. Cond. lever latency2.32.95.2-0.4-0.50.5-1.1-1.51.92.02.11.82.21.9-2.22.3
Pavlov. Cond. magazine entry latency1.21.54.2-0.90.8-0.8-0.10.8-0.9-1.7-1.3-1.3-1.5-1.12.1-1.6
Pavlov. Cond. change in total contacts1.01.12.9-0.60.8-0.8-0.50.5-0.7-1.5-1.1-1.0-1.1-0.71.7-1.4
Pavlov. Cond. index score2.83.67.0-0.10.4-0.40.81.7-2.0-2.4-2.3-2.2-2.4-2.12.6-2.5
Pavlov. Cond. latency score3.54.58.00.30.4-0.41.12.0-2.3-2.6-2.6-2.4-2.7-2.42.8-2.8
Pavlov. Cond. lever contacts2.22.75.10.20.6-0.60.61.4-1.7-2.1-2.0-1.8-2.0-1.72.3-2.2
Pavlov. Cond. magazine entry number0.60.82.11.2-0.30.30.1-0.60.51.20.80.91.10.7-1.51.1
Pavlov. Cond. intertrial magazine entries0.70.93.31.8-0.70.71.01.0-1.1-0.4-0.9-0.9-0.8-0.90.1-0.6
Pavlov. Cond. lever-magazine prob. diff.2.63.26.6-0.40.7-0.70.51.5-1.8-2.4-2.1-2.0-2.3-1.92.6-2.4
Pavlov. Cond. response bias0.70.92.3-1.30.8-0.8-0.50.3-0.4-1.4-0.8-0.8-1.0-0.61.5-1.1
Pavlov. Cond. lever latency0.20.20.7-0.80.1-0.10.60.6-0.1-0.6-0.2-0.2-0.4-0.50.6-0.4
Pavlov. Cond. magazine entry latency0.30.40.8-0.60.9-0.9-0.6-0.1-0.2-0.6-0.5-0.4-0.5-0.20.8-0.6
Pavlov. Cond. change in total contacts0.20.51.21.10.1-0.10.20.4-0.9-0.5-1.0-0.8-1.0-0.70.6-0.9
Pavlov. Cond. index score0.20.30.70.8-0.10.10.10.4-0.8-0.5-0.8-0.8-0.7-0.50.5-0.7
Pavlov. Cond. latency score0.20.30.80.9-0.20.20.10.4-0.7-0.3-0.7-0.7-0.6-0.50.4-0.6
Pavlov. Cond. lever contacts0.10.10.40.6-0.20.2-0.5-0.50.10.50.20.20.30.4-0.50.2
Pavlov. Cond. magazine entry number0.50.71.60.4-1.01.00.6-0.20.61.00.90.80.90.5-1.31.0
Pavlov. Cond. intertrial magazine entries0.92.03.21.5-1.21.21.81.7-1.7-1.1-1.3-1.5-1.3-1.70.7-1.1
Pavlov. Cond. lever-magazine prob. diff.0.20.40.70.70.1-0.10.00.4-0.8-0.5-0.9-0.8-0.8-0.60.6-0.8
Pavlov. Cond. response bias0.10.10.40.30.5-0.5-0.7-0.3-0.1-0.1-0.3-0.2-0.20.10.2-0.3
Time in closed arm before self-admin0.10.20.7-0.30.8-0.8-0.2-0.50.20.30.20.20.40.2-0.10.2
Time in closed arm after self-admin0.60.62.3-0.61.5-1.5-0.4-0.2-0.3-0.5-0.7-0.5-0.5-0.40.9-0.8
Time in open arm before self-admin0.30.41.1-1.0-0.00.0-0.8-0.40.80.10.80.70.50.7-0.40.7
Time in open arm after self-admin0.91.02.70.6-0.40.4-0.3-0.80.81.41.21.11.10.8-1.61.4
Bone: periosteal estimation2.04.715.63.4-3.93.92.92.0-1.40.3-0.5-0.7-0.5-1.2-1.10.1
Bone: periosteal perimeter1.83.59.92.6-3.13.12.82.0-1.5-0.0-0.7-0.9-0.8-1.5-0.4-0.4
Bone: post-yield work2.03.59.63.1-2.62.61.72.2-1.9-1.5-1.4-1.7-1.0-1.30.5-0.9
Progressive ratio test 1 active lever presses1.01.73.81.5-1.91.90.7-0.30.61.71.00.91.20.8-1.71.3
Progressive ratio test 1 breakpoint0.91.53.51.4-1.91.90.6-0.30.51.50.90.91.10.8-1.51.2
Progressive ratio test 1 inactive lever presses0.41.14.62.1-1.31.30.50.10.30.80.50.61.40.9-0.80.9
Progressive ratio test 2 active lever presses1.62.37.22.1-2.72.71.40.60.21.20.80.61.40.5-1.51.2
Progressive ratio test 2 breakpoint1.92.57.82.2-2.82.81.40.60.21.30.80.71.50.6-1.61.2
Progressive ratio test 2 inactive lever presses0.51.73.91.3-1.21.20.3-0.40.91.41.31.22.01.2-1.81.6
Incentive Sensitization - Responses0.51.34.32.1-2.12.11.11.0-0.20.10.20.11.10.2-0.50.6
Incentive Sensitization - Breakpoint0.71.54.92.2-2.22.21.21.0-0.20.20.20.11.20.3-0.60.6
Sum of active levers in priming session hrs 5-61.21.22.20.21.3-1.3-1.3-1.51.00.90.81.01.21.3-0.70.9
Progressive ratio0.51.62.7-0.4-0.20.21.21.5-1.2-1.6-1.3-1.3-1.6-1.61.4-1.5
Food seeking constrained by brief footshock1.72.24.3-0.5-2.02.01.92.1-1.3-1.2-0.9-1.4-1.2-1.70.8-1.0
Seeking ratio, punishment vs. effort0.00.00.10.1-0.30.3-0.3-0.00.00.20.1-0.10.30.2-0.30.2
Retroperitoneal fat weight0.10.41.21.1-0.40.40.30.8-0.6-1.1-0.5-0.4-0.3-0.50.4-0.3
Reaction time number correct0.20.61.71.3-1.11.11.20.2-0.41.1-0.0-0.10.0-0.4-0.90.2
Reaction time mean minus median0.10.91.7-1.3-0.80.8-0.4-0.41.20.11.31.11.11.0-0.81.0
Reaction time mean minus median AUC0.11.01.8-1.1-0.10.1-0.9-0.71.2-0.01.41.21.31.2-1.11.2
Reaction time num false alarms1.32.23.31.4-0.90.91.71.7-1.8-1.1-1.6-1.6-1.7-1.81.2-1.4
Reaction time num false alarms AUC0.92.13.21.0-0.70.71.41.7-1.7-1.4-1.6-1.7-1.7-1.81.4-1.5
Reaction time trials correct on left0.20.61.71.3-1.11.11.20.2-0.41.1-0.0-0.10.0-0.4-0.90.2
Reaction time trials on left0.20.61.61.3-1.11.11.20.2-0.41.1-0.1-0.10.0-0.4-0.80.2
Reaction time mean0.91.98.9-3.01.3-1.3-1.8-1.21.5-0.21.21.10.81.30.00.7
Reaction time mean AUC1.02.511.0-3.31.5-1.5-2.0-1.41.8-0.21.41.30.91.5-0.00.8
Median of all reaction times1.62.510.9-3.31.7-1.7-2.1-1.51.70.01.21.20.71.30.10.7
Reaction time omissions0.00.10.2-0.5-0.00.0-0.30.0-0.1-0.1-0.1-0.0-0.3-0.10.4-0.3
Reaction time false alarm rate1.11.52.70.5-0.30.30.91.5-1.3-1.6-1.3-1.4-1.4-1.41.5-1.3
Reaction time premature initiation rate0.61.02.21.0-1.41.41.51.1-1.0-0.4-0.7-1.0-0.7-1.00.3-0.6
Reaction time premature initiations0.72.15.11.9-2.32.32.21.4-1.30.1-0.8-1.2-0.7-1.3-0.2-0.5
Std. dev. reaction times0.30.92.8-1.70.0-0.0-1.2-0.61.2-0.41.10.91.01.2-0.30.8
Reaction time trials completed0.20.61.61.3-1.11.11.20.2-0.41.1-0.1-0.10.0-0.4-0.80.2
Reaction time trials AUC0.10.51.31.2-0.90.91.10.2-0.51.1-0.2-0.2-0.1-0.5-0.60.0
Run reversals in cocaine runway, females1.01.11.5-0.60.7-0.7-1.1-1.21.11.01.21.11.21.0-1.01.2
Run reversals in cocaine runway, males0.30.30.8-0.30.1-0.10.00.6-0.5-0.6-0.5-0.8-0.4-0.50.9-0.6
Latency to leave start box in cocaine runway0.40.51.20.2-0.80.81.00.9-0.7-0.3-0.5-0.2-1.1-0.90.3-0.5
Latency to leave start box in cocaine runway, F0.40.51.10.1-0.30.30.81.0-0.7-0.8-0.8-0.4-1.1-0.90.8-0.8
Latency to leave start box in cocaine runway, M0.20.20.80.3-0.90.90.70.2-0.30.40.0-0.0-0.4-0.4-0.50.2
Std. dev. time between licks in bursts0.91.75.3-2.31.5-1.5-2.0-1.61.30.10.90.80.81.2-0.10.6
Total sessions with >9 infusions0.20.31.61.3-0.30.3-0.5-0.1-0.0-0.10.0-0.11.00.70.10.2
Short access day 1 total inactive lever presses0.81.63.80.9-0.40.4-0.3-1.01.11.51.41.51.91.4-1.61.7
Short access day 10 total inactive lever presses0.10.84.52.11.0-1.0-0.20.1-0.9-0.3-1.1-0.7-0.6-0.30.7-0.8
Short access day 1 total infusions0.10.31.20.90.0-0.0-0.6-0.50.30.30.30.21.10.9-0.20.5
Short access day 10 total infusions0.30.61.80.10.0-0.0-0.7-0.70.90.40.80.81.31.3-0.30.8
Short access total infusions0.40.61.71.2-1.01.00.2-0.20.40.70.60.51.30.9-0.70.8
Short access day 1 locomotion0.10.20.90.10.6-0.6-0.8-0.30.30.00.20.30.90.70.40.3
Short access day 10 total locomotion0.10.20.8-0.90.7-0.7-0.5-0.40.40.10.30.40.20.10.20.2
Short access total locomotion0.50.72.0-0.60.9-0.9-1.4-0.90.90.10.70.81.11.00.10.7
One hour access (0.3 mA shock)2.42.911.22.3-3.43.41.91.0-0.20.90.60.21.20.3-1.30.9
Compulsive drug intake0.50.71.91.4-0.70.70.61.0-0.9-0.8-0.9-0.8-0.8-0.60.5-0.7
One hour access (shock baseline)0.51.34.90.8-2.22.21.20.50.20.90.80.31.20.3-1.10.9
Social response proportion1.62.13.7-1.20.1-0.1-0.5-1.51.71.91.81.81.51.2-1.71.7
Social responses1.11.42.80.1-0.90.9-0.2-0.61.21.11.51.41.71.3-1.41.6
Social time0.20.30.8-0.40.7-0.7-0.8-0.20.1-0.9-0.1-0.20.30.30.6-0.2
Soleus weight0.51.43.40.7-1.81.80.7-0.30.81.31.11.21.10.8-1.61.3
Bone: stiffness2.64.87.82.6-2.62.62.82.8-2.3-1.5-1.9-2.0-1.9-2.00.9-1.5
Tibialis anterior weight1.34.58.31.9-0.90.92.92.4-2.5-1.2-2.5-2.0-2.6-2.51.7-2.3
Time to tail flick, vehicle, before self-admin1.61.92.8-0.91.0-1.0-1.3-1.61.71.11.51.71.61.7-1.31.5
Time to tail flick, vehicle, after self-admin2.14.36.41.3-0.10.11.92.2-2.4-1.9-2.5-2.5-2.2-2.42.5-2.5
Time to tail flick, test, before self-admin0.40.41.50.7-1.21.21.20.4-0.10.6-0.00.2-0.3-0.3-0.3-0.0
Time to tail flick, test, after self-admin0.60.73.30.71.8-1.8-0.8-0.50.0-0.3-0.40.1-0.10.40.4-0.3
Delta time to tail flick, vehicle, before/after SA8.48.913.82.4-1.31.33.33.4-3.7-2.1-3.4-3.5-3.2-3.72.7-3.3
Delta time to tail flick, test, before/after SA0.40.42.00.11.4-1.4-0.9-0.2-0.1-0.7-0.4-0.2-0.00.20.5-0.2
Tibia length0.20.61.61.3-0.70.70.40.8-1.0-0.6-0.7-1.0-0.6-0.80.2-0.5
Ambulatory time before self-admin0.10.41.5-1.21.2-1.2-0.6-0.10.1-0.4-0.20.1-0.5-0.20.6-0.3
Ambulatory time after self-admin0.91.42.90.7-0.20.2-0.1-1.21.21.71.31.71.31.2-1.71.5
Bone: tissue strength0.60.61.5-0.6-0.10.1-0.9-0.81.00.40.90.70.91.2-0.50.8
Total heroin consumption0.70.83.82.0-1.11.11.11.0-0.7-0.1-0.5-0.6-0.1-0.50.1-0.2
Bone: trabecular number1.83.48.32.8-2.92.91.3-0.00.21.71.10.71.50.6-2.81.8
Bone: trabecular spacing1.11.74.7-0.41.4-1.4-0.50.4-1.0-1.3-1.5-1.3-1.4-0.92.2-1.7
Bone: trabecular thickness1.41.97.22.0-2.72.71.50.6-0.20.90.50.10.5-0.1-1.40.9
Bone: trabecular tissue density0.40.62.31.5-1.31.31.30.6-0.40.5-0.10.20.0-0.3-0.40.2
Water consumed over 24 hours0.91.83.01.10.4-0.41.11.3-1.6-1.3-1.7-1.6-1.7-1.61.1-1.5
Number of responses in last shaping day1.11.43.70.5-0.60.6-1.2-1.01.11.11.31.11.91.7-0.81.4