Hub : Genes

Hectd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Hectd2 0.2 0.15 3.9e-03 0.05 0.03 0.04 0.05 4.1e-05 2.8e-03 7.6e-04 8.4e-05
2 NAcc intron excision ratio chr1_243740486_243741401 0.02 0.02 6.9e-03 0.01 0.01 0 0 2.1e-02 3.2e-02 1.2e-01 4.8e-02
3 NAcc intron excision ratio chr1_243744524_243746360 0.02 0.02 6.8e-03 0.01 0.01 0 0.01 3.4e-03 2.6e-02 6.8e-02 2.0e-02
4 IC gene expression Hectd2 0.27 0.12 1.4e-05 0.12 0.11 0.05 0.1 9.4e-06 2.6e-05 3.0e-03 5.3e-05
5 PL gene expression Hectd2 0.11 0.05 6.3e-12 0.1 0.1 0.11 0.1 1.9e-11 1.7e-11 4.2e-12 1.4e-11
6 IL gene expression Hectd2 0.35 0.13 1.6e-05 0.02 0.17 0.16 0.13 9.9e-02 6.4e-05 9.8e-05 5.0e-04
7 NAcc mRNA stability Hectd2 0.03 0.02 1.8e-04 0.03 0.03 0.01 0.03 6.5e-06 4.8e-05 2.7e-03 6.7e-05
8 BLA gene expression Hectd2 0.16 0.07 5.8e-07 0.1 0.11 0.06 0.09 6.8e-06 3.1e-06 2.8e-04 2.1e-05
9 Adipose gene expression Hectd2 0.1 0.05 9.9e-10 0.06 0.08 0.07 0.07 9.2e-07 7.8e-09 4.5e-08 5.0e-08
10 pVTA gene expression Hectd2 0.09 0.05 5.6e-05 0.06 0.06 0.05 0.06 2.0e-05 1.7e-05 1.0e-04 1.1e-05
11 NAcc gene expression Hectd2 0.06 0.03 1.5e-07 0.03 0.05 0.04 0.04 1.0e-04 9.4e-08 8.1e-07 7.6e-07
12 Liver gene expression Hectd2 0.06 0.04 8.5e-05 0.04 0.03 0.01 0.03 6.3e-05 5.5e-04 1.0e-02 6.0e-04
13 Brain gene expression Hectd2 0.14 0.06 3.9e-11 0.1 0.12 0.1 0.11 1.2e-09 3.8e-11 8.1e-10 3.8e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density2.74.713.5-3.53.7-3.7-2.1-0.4-0.2-1.90.90.51.20.12.91.7
Area under the delay curve0.91.04.7-2.2-0.80.80.0-0.3-1.30.7-1.4-1.3-0.6-0.5-0.6-0.9
BMI with tail0.10.20.50.20.7-0.7-0.0-0.00.40.20.60.50.70.30.40.6
BMI without tail0.41.14.1-1.10.1-0.1-0.1-1.2-1.12.0-1.1-1.1-0.7-0.8-1.1-1.0
Body weight1.87.716.2-4.02.7-2.7-2.3-3.5-3.13.3-2.6-2.9-1.8-2.4-1.8-2.0
Weight adjusted by age0.40.61.6-0.9-0.40.40.40.90.4-1.20.70.70.90.51.30.9
Bone surface1.62.99.1-3.02.8-2.8-1.3-0.2-0.1-1.40.80.51.10.42.21.4
Bone volume2.13.712.0-3.53.5-3.5-2.1-0.9-0.8-1.10.2-0.10.4-0.41.90.9
Breakpoint value in progressive ratio session0.91.11.7-1.20.4-0.4-1.0-1.3-1.31.1-1.1-1.3-0.7-1.2-0.9-0.9
Number of licking bursts0.61.03.01.1-1.71.71.00.1-0.51.5-0.6-1.0-0.4-0.5-0.9-0.6
Context. condit. distance diff. score1.51.84.6-0.81.8-1.8-2.1-1.6-1.20.4-1.0-0.7-1.4-1.5-0.7-1.0
Locomotion velocity, session 13.23.47.12.1-2.02.02.72.32.0-0.81.81.61.71.91.11.6
Locomotion distance, session 10.30.40.70.9-0.80.80.80.60.6-0.40.60.50.50.40.30.5
Locomotion velocity, session 20.50.62.21.5-1.01.01.20.80.8-0.20.60.60.30.60.10.4
Locomotion distance, session 20.40.61.20.8-0.70.70.1-0.6-0.61.1-0.7-0.8-0.9-0.8-1.0-0.8
Locomotion velocity, session 30.40.40.7-0.20.6-0.6-0.6-0.8-0.70.5-0.6-0.6-0.8-0.8-0.7-0.6
Locomotion distance, session 31.82.03.4-0.50.9-0.9-1.6-1.8-1.50.9-1.4-1.4-1.9-1.8-1.4-1.6
Stereotopy head waving bouts, day 30.91.11.8-0.00.0-0.01.01.11.2-0.81.11.41.31.41.11.2
Stereotopy head waving duration, day 30.80.91.7-0.5-0.10.10.91.11.0-0.70.91.11.31.31.11.1
Locomotion velocity, session 71.31.42.7-1.20.6-0.6-1.7-1.2-1.40.3-1.4-1.2-1.4-1.5-0.8-1.3
Locomotion distance, session 71.01.32.7-1.40.9-0.9-1.6-1.2-1.30.2-1.2-1.1-1.4-1.3-0.5-1.1
Stereotopy head waving bouts, day 70.20.20.60.4-0.30.30.80.50.60.10.50.50.40.60.20.4
Stereotopy head waving duration, day 70.40.51.00.10.0-0.00.90.70.8-0.30.80.81.01.00.60.8
Locomotion velocity, session 80.10.10.50.20.7-0.7-0.5-0.10.2-0.40.20.2-0.0-0.10.40.1
Locomotion distance, session 80.81.12.30.40.6-0.6-1.5-1.3-1.00.6-0.9-0.7-1.5-1.5-1.0-1.1
Degree of sensitization distance0.10.10.5-0.7-0.40.4-0.10.2-0.2-0.0-0.3-0.2-0.10.00.1-0.1
Degree of sensitization stereotypy0.00.00.1-0.10.1-0.10.40.10.20.10.30.20.30.40.10.3
Conditioned locomotion0.20.20.9-0.20.7-0.7-0.9-0.4-0.4-0.4-0.1-0.3-0.4-0.60.1-0.0
Cocaine response after cond. corrected0.10.11.0-1.00.0-0.00.20.4-0.0-0.30.10.20.30.20.40.2
Cocaine response after cond. not corrected0.60.63.1-1.80.3-0.3-0.5-0.6-1.00.5-0.9-0.8-0.7-0.7-0.5-0.7
Cocaine response before conditioning1.51.83.1-1.3-0.00.0-0.7-1.5-1.51.5-1.7-1.7-1.4-1.1-1.7-1.6
Saline control response0.91.15.9-2.4-0.00.0-0.9-0.5-1.3-0.0-1.4-0.9-1.1-0.9-0.4-1.1
Bone: connectivity density2.13.38.2-2.22.3-2.3-0.90.60.8-2.11.61.31.81.12.92.1
Bone: cortical apparent density0.81.23.10.5-1.81.81.51.30.9-0.40.61.00.71.10.30.6
Bone: cortical area3.25.09.6-3.12.7-2.7-2.7-2.6-2.41.3-1.9-2.1-1.8-2.1-0.8-1.5
Bone: cortical porosity0.10.10.30.6-0.40.40.10.30.4-0.50.20.30.20.2-0.10.1
Bone: cortical porosity0.00.00.10.10.1-0.1-0.2-0.1-0.1-0.0-0.1-0.1-0.1-0.2-0.2-0.2
Bone: cortical thickness2.23.65.8-2.31.0-1.0-1.6-2.1-2.42.0-2.2-2.3-1.8-2.0-1.5-1.9
Bone: cortical thickness0.50.61.0-0.6-0.60.6-0.0-0.6-1.00.9-1.0-1.0-0.8-0.9-0.9-0.9
Bone: cortical tissue density1.01.43.50.7-1.91.91.61.41.1-0.50.71.10.81.20.40.7
Condit. Reinf. active minus inactive responses0.60.71.50.2-0.80.80.3-0.3-0.71.1-0.9-0.8-1.0-0.7-1.2-1.0
Condit. Reinf. active-inactive response ratio0.70.72.11.4-1.01.01.31.00.8-0.20.60.60.40.7-0.10.3
Condit. Reinf. active responses1.31.62.8-1.20.1-0.1-0.9-1.2-1.61.2-1.7-1.4-1.6-1.4-1.3-1.6
Condit. Reinf. inactive responses1.92.46.4-2.51.1-1.1-1.7-1.7-1.90.9-1.7-1.5-1.4-1.6-0.6-1.3
Incentive salience index mean1.72.13.9-0.2-0.90.9-0.1-1.0-1.51.9-1.8-1.7-1.8-1.4-2.0-1.9
Condit. Reinf. lever presses1.62.24.6-0.1-1.21.20.2-0.9-1.42.2-1.8-1.5-1.8-1.3-2.1-1.9
Condit. Reinf. active minus inactive responses1.51.93.3-1.00.6-0.6-1.4-1.6-1.71.4-1.6-1.5-1.7-1.8-1.0-1.5
Condit. Reinf. active-inactive response ratio0.40.40.9-0.3-0.20.2-0.5-0.6-0.90.8-0.8-0.7-0.9-1.0-0.5-0.7
Condit. Reinf. active responses1.92.64.9-2.21.7-1.7-1.8-1.8-1.90.9-1.5-1.5-1.5-1.8-0.6-1.3
Condit. Reinf. inactive responses1.11.54.4-2.11.8-1.8-1.3-1.1-1.20.3-0.9-1.0-0.7-0.9-0.1-0.6
Condit. Reinf. lever presses0.10.10.4-0.60.6-0.6-0.2-0.1-0.4-0.2-0.2-0.3-0.3-0.40.3-0.1
Condit. Reinf. lever reinforcers received1.41.93.4-1.81.3-1.3-1.5-1.5-1.70.9-1.4-1.3-1.4-1.6-0.6-1.1
Conditioned reinforcement - actives0.40.73.4-1.91.3-1.3-0.6-0.5-0.2-0.50.1-0.10.80.40.50.3
Conditioned reinforcement - inactives0.50.83.7-1.91.1-1.1-0.50.00.3-1.00.40.60.90.80.90.7
Conditioned locomotion0.91.22.5-0.81.2-1.2-0.00.40.9-1.21.21.11.61.21.21.3
Patch foraging indifference point 0 sec0.40.74.5-0.70.3-0.30.6-0.9-0.72.1-0.6-1.10.2-0.1-0.7-0.3
Patch foraging indifference point AUC0.91.33.5-1.8-1.01.00.4-0.7-1.01.9-1.5-1.1-0.7-0.2-1.0-1.2
Delay disc. indifference point, 0s delay2.02.24.5-2.1-0.30.3-1.5-1.4-1.91.0-1.9-1.7-1.5-1.6-1.0-1.5
Delay disc. indifference point, 16s delay0.40.54.7-2.20.3-0.3-0.0-0.1-0.80.0-0.7-0.7-0.0-0.00.2-0.2
Delay disc. indifference point, 2s delay0.30.31.6-1.3-0.80.80.40.6-0.1-0.5-0.10.10.40.30.50.3
Delay disc. indifference point, 24s delay1.71.93.8-1.6-0.90.90.0-0.5-1.51.8-2.0-1.7-1.4-0.8-1.5-1.7
Delay disc. indifference point, 4s delay1.51.65.2-2.3-0.30.3-0.7-0.9-1.70.9-1.7-1.6-1.1-1.1-0.9-1.3
Delay disc. indifference point, 8s delay0.80.93.0-1.3-1.71.71.20.5-0.60.5-0.9-0.8-0.10.2-0.5-0.5
Indifference point function ln k0.30.61.90.91.4-1.4-0.9-0.40.1-0.80.60.3-0.1-0.60.30.4
Indifference point function log k0.30.61.90.91.4-1.4-0.9-0.40.1-0.80.60.3-0.1-0.60.30.4
Patch foraging total patch changes 0 sec0.40.74.2-0.80.4-0.40.6-1.0-0.72.1-0.5-1.10.2-0.1-0.7-0.3
Patch foraging total patch changes 12 sec0.50.61.8-0.9-1.21.21.30.2-0.11.3-0.4-0.30.40.7-0.3-0.2
Patch foraging total patch changes 18 sec0.40.62.9-1.3-0.60.60.5-0.5-0.71.7-0.8-0.8-0.1-0.1-0.5-0.5
Patch foraging total patch changes 24 sec1.22.18.2-1.5-0.20.2-0.0-1.6-1.62.9-1.7-1.9-0.9-0.9-1.3-1.3
Patch foraging total patch changes 6 sec0.60.94.0-1.2-0.80.81.3-0.3-0.62.0-0.8-1.00.20.4-0.8-0.6
Patch foraging time to switch 0 sec0.51.14.92.2-1.31.31.01.20.9-0.80.90.60.50.50.40.6
Patch foraging water rate 0 sec0.20.41.2-0.70.8-0.8-0.7-1.1-0.50.7-0.5-0.3-0.4-0.5-0.4-0.5
Patch foraging water rate 12 sec0.20.40.9-0.51.0-1.0-0.6-0.8-0.60.5-0.3-0.70.0-0.6-0.6-0.3
Patch foraging water rate 18 sec0.50.71.5-0.41.2-1.2-1.1-1.2-0.70.5-0.5-0.8-0.5-0.8-0.7-0.6
Patch foraging water rate 24 sec2.02.84.4-2.11.6-1.6-1.9-2.1-1.91.4-1.6-1.7-1.4-1.7-0.9-1.5
Patch foraging water rate 6 sec0.10.20.30.30.4-0.40.3-0.00.50.50.60.50.60.40.50.6
Seeking ratio, delayed vs. immediate footshock0.20.31.21.1-0.10.1-0.4-0.5-0.10.9-0.2-0.1-0.8-0.4-0.4-0.4
Distance traveled before self-admin0.20.20.50.6-0.70.70.1-0.2-0.20.3-0.4-0.1-0.7-0.4-0.6-0.5
Distance traveled after self-admin2.02.55.3-0.8-0.10.10.61.81.5-2.21.62.01.71.72.31.9
Extensor digitorum longus weight1.14.57.4-1.51.0-1.0-2.6-2.6-2.41.8-2.4-2.1-2.7-2.4-1.7-2.3
Bone: elastic displacement4.85.610.63.3-2.22.22.62.82.7-1.82.42.52.12.21.22.0
Bone: elastic work3.95.17.22.7-1.61.62.12.72.7-2.12.52.72.22.31.62.2
Bone: endosteal estimation1.53.311.9-2.73.4-3.4-2.2-1.1-0.5-1.10.30.20.2-0.31.70.8
Bone: endosteal perimeter1.53.111.6-1.73.4-3.4-2.3-1.0-0.1-1.50.80.40.6-0.31.91.1
Epididymis fat weight0.41.44.4-1.92.1-2.1-1.5-1.1-0.70.5-0.1-0.10.1-0.60.70.2
Delta time in closed arm before/after self-admin0.50.52.11.5-0.50.50.5-0.3-0.11.1-0.3-0.5-0.4-0.3-1.1-0.6
Delta time in open arm before/after self-admin0.40.41.4-1.2-0.60.60.10.70.2-0.90.20.70.20.40.90.5
Diff in mean of infusions in LGA sessions0.20.30.70.40.7-0.7-0.7-0.8-0.20.3-0.1-0.2-0.3-0.6-0.4-0.2
Delay discount exponential model param1.01.14.62.20.7-0.7-0.00.31.4-0.81.41.40.70.50.71.0
Extinction: sum of active levers before priming1.01.11.5-0.10.7-0.7-1.0-1.2-1.11.0-1.1-1.2-1.2-1.2-1.2-1.2
Active lever presses in extinction session 60.80.82.8-1.70.5-0.5-1.6-0.7-1.1-0.0-0.8-0.7-0.6-1.2-0.1-0.6
Bone: final force1.11.83.6-1.91.9-1.9-1.5-1.6-1.40.9-1.0-1.2-0.9-1.1-0.4-0.7
Bone: final moment0.71.13.3-1.71.8-1.8-1.1-1.2-0.90.4-0.5-0.7-0.4-0.60.1-0.1
Food consumed during 24 hour testing period0.20.31.5-0.00.3-0.30.1-0.7-0.51.2-0.5-0.7-0.5-0.4-0.3-0.5
Glucose0.10.21.11.10.2-0.2-0.2-0.40.10.7-0.0-0.1-0.2-0.2-0.4-0.2
Heart weight0.71.02.8-0.40.5-0.51.30.71.10.31.10.91.41.70.81.2
Delay discount hyperbolic model param0.70.83.81.90.8-0.8-0.20.11.1-0.61.21.10.40.30.50.8
Intermittent access intake day 1-15 change0.40.83.4-0.31.8-1.8-0.7-0.60.3-0.10.70.21.10.40.40.7
Intermittent access intake escalation0.40.73.4-0.21.8-1.8-1.0-0.80.1-0.00.50.20.80.20.40.5
Intermittent access intake escalation 20.30.31.11.10.9-0.9-0.5-0.70.40.30.50.30.50.0-0.00.2
Intermitt. access day 1 inactive lever presses0.10.51.2-0.7-1.11.11.01.00.4-0.60.20.70.30.70.50.4
Intermitt. access day 15 inactive lever presses0.91.94.6-2.11.2-1.2-0.20.60.8-1.71.11.21.61.32.01.5
Intermitt. access escalation Index0.20.30.8-0.1-0.60.6-0.10.1-0.30.4-0.7-0.3-0.6-0.1-0.9-0.8
Intermittent access day 1 total infusions0.40.73.2-1.81.3-1.3-0.9-0.4-0.2-0.60.10.10.60.10.60.4
Intermittent access day 15 total infusions1.31.97.7-2.02.8-2.8-1.7-1.1-0.3-0.40.2-0.00.70.10.50.4
Intermittent access terminal intake (last 3 days)1.01.34.9-1.12.2-2.2-1.1-0.60.4-0.60.70.61.10.50.80.8
Intermittent access total infusions0.91.04.0-1.32.0-2.0-1.4-0.8-0.0-0.40.30.30.70.20.60.5
Intermittent access day 1 locomotion0.40.52.1-1.51.3-1.3-0.8-0.6-0.4-0.4-0.1-0.10.2-0.20.10.1
Intermittent access day 15 total locomotion0.81.53.8-0.52.0-2.0-0.6-0.10.8-1.01.31.11.50.81.41.4
Intermittent access total locomotion0.80.92.8-0.81.7-1.7-0.9-0.40.4-0.80.80.81.10.41.00.9
Intermittent access standard deviation0.30.73.2-1.01.8-1.8-1.0-0.6-0.2-0.30.2-0.00.30.00.40.3
Left kidney weight0.94.06.6-2.22.1-2.1-1.7-2.6-2.22.5-1.8-2.2-1.3-1.7-1.5-1.5
Right kidney weight1.04.712.8-1.91.5-1.5-1.3-2.9-2.33.6-2.1-2.7-1.6-1.8-2.0-1.9
Cocaine induced anxiety0.20.32.0-1.40.1-0.1-0.8-0.1-0.5-0.3-0.4-0.2-0.2-0.30.3-0.2
Post-drug Anxiety0.70.71.9-1.00.6-0.6-0.20.80.5-1.40.70.70.80.71.40.9
Baseline Anxiety1.01.22.10.60.9-0.90.40.91.2-1.51.41.21.00.91.41.3
Tail length2.49.218.5-4.31.4-1.4-2.3-3.6-3.73.6-3.5-3.6-2.7-2.8-2.2-2.9
Length with tail3.012.836.3-6.03.0-3.0-3.1-4.1-4.33.2-3.7-4.1-2.6-3.1-2.0-2.8
Length without tail2.27.020.2-4.53.7-3.7-3.1-2.8-2.70.9-1.9-2.3-1.3-2.1-0.5-1.2
Times rat made contact with spout0.70.92.7-1.6-0.40.4-0.7-0.7-1.20.7-1.2-1.0-0.9-1.0-0.5-0.9
Lifetime Intake0.91.13.9-1.42.0-2.0-1.2-0.50.1-0.60.50.30.90.30.70.6
Liver weight, left0.71.21.9-1.11.4-1.4-1.2-1.4-1.20.7-0.9-1.1-0.9-1.2-0.4-0.7
Liver weight, right0.71.35.1-2.31.8-1.8-1.2-1.3-0.80.7-0.4-0.50.1-0.40.2-0.0
Locomotor activity0.20.41.00.9-0.90.91.00.50.50.30.40.30.30.20.10.4
Locomotor testing distance0.40.82.31.1-1.31.31.50.90.70.30.70.40.80.60.20.6
Locomotor testing rearing0.10.20.7-0.00.0-0.0-0.6-0.5-0.50.5-0.4-0.5-0.5-0.8-0.4-0.5
Locomotion in novel chamber0.50.61.21.11.0-1.0-1.00.00.5-1.00.90.90.1-0.30.90.7
Locomotion in novel chamber post-restriction1.62.75.3-1.81.7-1.7-2.3-1.9-1.80.6-1.5-1.4-1.5-1.9-0.6-1.4
Fecal boli incidents, locomotor time 10.10.10.7-0.00.1-0.1-0.8-0.5-0.10.3-0.4-0.0-0.3-0.2-0.4-0.5
Change in fecal boli incidents, locomotor task0.20.20.4-0.2-0.40.40.3-0.2-0.40.5-0.4-0.6-0.3-0.3-0.6-0.4
Time >=10cm from walls, locomotor time 14.04.27.7-2.02.0-2.0-2.8-2.3-2.31.0-2.1-2.1-2.3-2.3-1.0-1.9
Bouts of movement, locomotor time 10.30.31.3-0.10.3-0.3-0.6-0.7-0.51.1-0.2-0.70.0-0.7-0.4-0.2
Total resting periods, locomotor time 10.40.51.1-0.80.4-0.4-0.8-0.8-0.81.1-0.5-0.9-0.0-0.8-0.5-0.3
Rest time, locomotor task time 10.50.61.80.2-0.80.80.70.90.8-0.30.80.71.30.90.40.8
Distance moved, locomotor task time 11.32.04.6-1.10.0-0.0-0.8-1.3-1.71.2-1.9-1.6-2.1-1.5-1.4-1.8
Vertical activity count, locomotor time 10.10.30.70.20.8-0.8-0.4-0.7-0.50.1-0.5-0.6-0.8-0.6-0.2-0.5
Time >=10cm from walls, locomotor time 21.72.44.5-2.10.1-0.1-1.3-1.5-1.91.5-2.1-1.8-1.7-1.4-1.2-1.8
Bouts of movement, locomotor time 20.40.72.90.5-1.71.71.00.3-0.00.9-0.3-0.30.00.1-0.8-0.4
Total resting periods, locomotor time 20.40.82.80.6-1.71.70.80.2-0.21.1-0.5-0.5-0.1-0.1-1.0-0.5
Rest time, locomotor task time 20.30.40.90.5-0.20.2-0.5-0.6-0.60.8-0.5-0.9-0.3-0.9-0.7-0.5
Distance moved, locomotor task time 20.91.02.4-1.20.2-0.2-0.8-1.0-1.10.9-1.4-0.9-1.5-0.9-0.9-1.3
Vertical activity count, locomotor time 20.10.10.5-0.2-0.40.40.60.20.3-0.1-0.10.30.10.7-0.0-0.1
Light reinforcement 10.30.61.7-0.40.0-0.00.40.60.6-0.70.90.71.30.61.31.3
Light reinforcement 22.94.57.71.5-2.52.52.62.82.1-1.31.92.02.22.21.51.9
Bone: marrow area1.63.512.5-2.83.5-3.5-2.2-1.1-0.4-1.20.40.30.3-0.31.80.9
Bone: maximum diameter2.95.519.5-3.34.4-4.4-3.3-1.9-1.2-1.0-0.1-0.4-0.3-1.21.60.4
Bone: maximum force1.11.96.4-2.32.5-2.5-1.6-1.4-1.00.2-0.4-0.7-0.4-0.70.4-0.0
Bone: maximum moment0.91.55.9-2.12.4-2.4-1.2-1.0-0.5-0.20.0-0.30.1-0.20.80.4
Mean time between licks in bursts0.61.64.62.1-1.11.11.91.51.4-0.41.11.00.91.40.40.8
Mean num. licks in bursts0.50.83.3-1.81.3-1.3-1.3-0.5-0.2-1.0-0.10.4-0.2-0.10.50.0
Cd content in liver1.01.23.31.8-1.01.01.81.11.2-0.10.90.80.71.3-0.10.6
Co content in liver2.12.44.31.0-0.80.81.82.11.9-1.51.61.91.62.10.91.5
Cu content in liver3.23.86.50.2-1.61.62.52.61.8-1.81.81.62.42.31.92.0
Fe content in liver0.50.62.31.0-1.51.51.10.40.20.60.0-0.10.10.2-0.4-0.1
K content in liver0.40.31.30.4-1.11.1-0.20.1-0.30.0-0.5-0.3-0.6-0.4-0.6-0.6
Mg content in liver0.20.20.90.3-1.01.00.60.70.3-0.30.10.30.10.2-0.10.1
Mn content in liver0.50.51.50.8-1.21.21.10.80.60.00.40.30.50.70.10.3
Na content in liver0.70.82.10.5-1.51.50.10.1-0.60.5-0.9-0.7-1.0-0.7-1.1-1.0
Rb content in liver0.10.20.3-0.50.3-0.3-0.4-0.5-0.50.4-0.3-0.5-0.3-0.50.1-0.1
Se content in liver8.610.232.24.2-5.75.75.13.02.11.01.00.91.32.2-0.90.5
Sr content in liver3.63.24.91.0-0.40.41.62.12.1-1.92.12.22.02.11.82.0
Zn content in liver2.52.811.22.4-3.33.32.01.10.60.7-0.20.1-0.20.4-1.2-0.6
Bone: minimum diameter3.05.517.7-2.84.2-4.2-3.3-2.6-1.70.4-0.9-1.2-1.1-1.60.2-0.6
Time in familiar zone, hab. session 10.40.41.0-0.30.2-0.20.30.60.6-1.00.70.60.70.60.80.7
Time in novel zone, hab. session 10.30.31.11.1-0.80.80.3-0.1-0.00.8-0.2-0.2-0.2-0.1-0.6-0.3
Total zone transitions, hab. session 10.10.10.3-0.2-0.10.10.00.20.1-0.60.30.20.20.00.50.4
Total locomotion distance, hab. session 10.30.41.61.0-1.31.30.40.40.1-0.30.0-0.0-0.2-0.3-0.3-0.1
Locomotion velocity, hab. session 10.40.62.31.1-1.51.50.40.2-0.10.0-0.3-0.1-0.6-0.5-0.7-0.4
Time in familiar zone, hab. session 20.50.51.00.4-0.40.41.01.00.8-0.40.70.70.60.90.60.7
Time in novel zone, hab. session 20.00.00.10.10.0-0.0-0.2-0.20.1-0.00.10.10.20.00.10.1
Total zone transitions, hab. session 20.10.10.80.3-0.50.50.90.20.10.30.1-0.10.10.1-0.20.1
Total locomotion distance, hab. session 20.30.42.01.4-0.90.90.80.30.30.20.20.1-0.1-0.1-0.3-0.0
Locomotion velocity, hab. session 20.30.41.81.4-1.01.00.50.1-0.00.5-0.1-0.2-0.4-0.4-0.7-0.3
Novel to familiar place preference ratio0.30.31.4-1.20.5-0.5-0.8-0.4-0.3-0.1-0.0-0.10.4-0.20.50.3
Novelty place preference0.30.31.1-1.00.6-0.6-0.8-0.3-0.1-0.20.20.10.5-0.00.70.5
Time in novel zone, NPP test0.20.20.5-0.60.4-0.4-0.7-0.3-0.0-0.20.30.10.50.00.70.5
Total zone transitions, NPP test0.40.50.70.5-0.80.80.4-0.3-0.60.8-0.7-0.8-0.8-0.7-0.9-0.8
Total locomotion distance, NPP test0.50.72.71.1-1.61.60.80.1-0.20.8-0.4-0.3-0.5-0.4-0.7-0.6
Locomotion velocity, NPP test0.60.92.30.5-1.51.50.5-0.2-0.61.1-0.9-0.7-0.8-0.7-1.0-1.0
Intraocular pressure0.10.20.5-0.40.7-0.7-0.1-0.5-0.10.70.2-0.00.2-0.00.70.5
Delta distance traveled before/after self-admin1.81.94.2-1.61.5-1.5-0.50.80.8-1.81.21.31.61.12.11.5
Delta ambulatory time before/after self-admin1.92.35.6-2.41.7-1.7-0.70.70.8-1.81.11.31.51.22.11.5
Parametrial fat weight1.84.28.6-0.7-0.70.7-0.4-2.0-2.22.9-2.5-2.5-2.2-1.9-2.9-2.5
Pavlov. Cond. lever latency2.32.95.20.40.5-0.51.11.51.9-2.02.11.82.21.92.22.3
Pavlov. Cond. magazine entry latency1.21.54.20.9-0.80.80.1-0.8-0.91.7-1.3-1.3-1.5-1.1-2.1-1.6
Pavlov. Cond. change in total contacts1.01.12.90.6-0.80.80.5-0.5-0.71.5-1.1-1.0-1.1-0.7-1.7-1.4
Pavlov. Cond. index score2.93.67.00.1-0.40.4-0.8-1.7-2.02.4-2.3-2.2-2.4-2.1-2.6-2.5
Pavlov. Cond. latency score3.64.58.0-0.3-0.40.4-1.1-2.0-2.32.6-2.6-2.4-2.7-2.4-2.8-2.8
Pavlov. Cond. lever contacts2.22.75.1-0.2-0.60.6-0.6-1.4-1.72.1-2.0-1.8-2.0-1.7-2.3-2.2
Pavlov. Cond. magazine entry number0.60.82.1-1.20.3-0.3-0.10.60.5-1.20.80.91.10.71.51.1
Pavlov. Cond. intertrial magazine entries0.70.93.3-1.80.7-0.7-1.0-1.0-1.10.4-0.9-0.9-0.8-0.9-0.1-0.6
Pavlov. Cond. lever-magazine prob. diff.2.63.26.60.4-0.70.7-0.5-1.5-1.82.4-2.1-2.0-2.2-1.9-2.6-2.4
Pavlov. Cond. response bias0.70.92.31.3-0.80.80.5-0.3-0.41.4-0.8-0.8-1.0-0.6-1.5-1.1
Pavlov. Cond. lever latency0.20.20.70.8-0.10.1-0.6-0.6-0.10.6-0.2-0.2-0.4-0.5-0.6-0.4
Pavlov. Cond. magazine entry latency0.30.40.80.6-0.90.90.60.1-0.20.6-0.5-0.4-0.5-0.2-0.8-0.6
Pavlov. Cond. change in total contacts0.30.51.2-1.1-0.10.1-0.2-0.4-0.90.5-1.0-0.8-1.0-0.7-0.6-0.9
Pavlov. Cond. index score0.30.30.7-0.80.1-0.1-0.1-0.4-0.80.5-0.8-0.8-0.7-0.5-0.5-0.7
Pavlov. Cond. latency score0.20.30.8-0.90.2-0.2-0.1-0.4-0.70.3-0.7-0.7-0.6-0.5-0.4-0.6
Pavlov. Cond. lever contacts0.10.10.4-0.60.2-0.20.50.50.1-0.50.20.20.30.40.50.2
Pavlov. Cond. magazine entry number0.60.71.6-0.41.0-1.0-0.60.20.6-1.00.90.80.90.51.31.0
Pavlov. Cond. intertrial magazine entries1.32.03.2-1.51.2-1.2-1.8-1.7-1.71.1-1.3-1.5-1.4-1.7-0.7-1.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.7-0.10.1-0.0-0.4-0.80.5-0.9-0.8-0.8-0.6-0.6-0.8
Pavlov. Cond. response bias0.10.10.4-0.3-0.50.50.70.3-0.10.1-0.3-0.2-0.20.1-0.2-0.3
Time in closed arm before self-admin0.10.20.70.3-0.80.80.20.50.2-0.30.20.20.40.20.10.2
Time in closed arm after self-admin0.60.62.30.6-1.51.50.40.2-0.30.5-0.7-0.5-0.5-0.4-0.9-0.8
Time in open arm before self-admin0.30.41.11.00.0-0.00.80.40.8-0.10.80.70.50.70.40.7
Time in open arm after self-admin0.91.02.7-0.60.4-0.40.30.80.8-1.41.21.11.10.81.61.4
Bone: periosteal estimation2.24.715.6-3.43.9-3.9-2.9-2.0-1.4-0.3-0.5-0.7-0.6-1.21.10.1
Bone: periosteal perimeter2.03.59.9-2.63.1-3.1-2.8-2.0-1.50.0-0.7-0.9-0.8-1.50.4-0.4
Bone: post-yield work2.43.59.6-3.12.6-2.6-1.7-2.2-1.91.5-1.4-1.7-1.0-1.3-0.5-0.9
Progressive ratio test 1 active lever presses1.41.73.8-1.51.9-1.9-0.70.30.6-1.71.00.91.20.81.71.3
Progressive ratio test 1 breakpoint1.21.53.5-1.41.9-1.9-0.60.30.5-1.50.90.91.10.81.51.2
Progressive ratio test 1 inactive lever presses0.71.14.6-2.11.3-1.3-0.5-0.10.3-0.80.50.61.40.90.80.9
Progressive ratio test 2 active lever presses1.92.37.2-2.12.7-2.7-1.4-0.70.2-1.20.80.61.40.51.51.2
Progressive ratio test 2 breakpoint2.22.57.8-2.22.8-2.8-1.4-0.60.2-1.30.80.71.40.61.61.2
Progressive ratio test 2 inactive lever presses1.01.73.9-1.31.2-1.2-0.30.40.9-1.41.31.22.01.21.81.6
Incentive Sensitization - Responses0.91.34.3-2.12.1-2.1-1.1-1.0-0.2-0.10.20.11.10.20.50.6
Incentive Sensitization - Breakpoint1.11.54.9-2.22.2-2.2-1.2-1.0-0.2-0.20.20.11.10.30.60.6
Sum of active levers in priming session hrs 5-61.31.22.2-0.2-1.31.31.31.51.0-0.90.81.01.21.30.70.9
Progressive ratio1.01.62.70.40.2-0.2-1.2-1.5-1.21.6-1.3-1.3-1.6-1.6-1.4-1.5
Food seeking constrained by brief footshock1.82.24.30.52.0-2.0-1.9-2.1-1.31.2-0.9-1.4-1.2-1.7-0.8-1.0
Seeking ratio, punishment vs. effort0.00.00.1-0.10.3-0.30.30.00.0-0.20.1-0.10.30.20.30.2
Retroperitoneal fat weight0.10.41.2-1.10.4-0.4-0.3-0.8-0.61.1-0.5-0.4-0.3-0.5-0.4-0.3
Reaction time number correct0.30.61.7-1.31.1-1.1-1.2-0.2-0.4-1.1-0.0-0.10.0-0.40.90.2
Reaction time mean minus median0.30.91.71.30.8-0.80.40.41.2-0.11.31.11.11.00.81.0
Reaction time mean minus median AUC0.41.01.81.10.1-0.10.90.71.20.01.41.21.31.21.11.2
Reaction time num false alarms1.52.23.3-1.40.9-0.9-1.7-1.7-1.81.1-1.6-1.6-1.7-1.8-1.2-1.4
Reaction time num false alarms AUC1.32.13.2-1.00.7-0.7-1.4-1.7-1.71.4-1.6-1.7-1.7-1.8-1.4-1.5
Reaction time trials correct on left0.30.61.7-1.31.1-1.1-1.2-0.2-0.4-1.1-0.0-0.10.0-0.40.90.2
Reaction time trials on left0.30.61.6-1.31.1-1.1-1.2-0.3-0.4-1.1-0.1-0.10.0-0.40.80.2
Reaction time mean1.21.98.93.0-1.31.31.81.21.50.21.21.10.81.3-0.00.7
Reaction time mean AUC1.52.511.03.3-1.51.52.01.41.80.21.41.30.91.50.00.8
Median of all reaction times1.72.510.93.3-1.71.72.11.51.7-0.01.21.20.71.3-0.10.7
Reaction time omissions0.00.10.20.50.0-0.00.3-0.0-0.10.1-0.1-0.0-0.3-0.1-0.4-0.3
Reaction time false alarm rate1.11.52.7-0.50.3-0.3-0.9-1.5-1.31.6-1.3-1.4-1.4-1.4-1.5-1.3
Reaction time premature initiation rate0.71.02.2-1.01.4-1.4-1.5-1.1-1.00.4-0.7-1.0-0.7-1.0-0.3-0.6
Reaction time premature initiations1.22.15.1-1.92.3-2.3-2.2-1.4-1.3-0.1-0.8-1.2-0.7-1.30.2-0.5
Std. dev. reaction times0.50.92.81.7-0.00.01.20.61.20.41.10.91.01.20.30.8
Reaction time trials completed0.30.61.6-1.31.1-1.1-1.2-0.3-0.4-1.1-0.1-0.10.0-0.40.80.2
Reaction time trials AUC0.30.51.3-1.20.9-0.9-1.1-0.2-0.5-1.1-0.2-0.2-0.1-0.50.60.0
Run reversals in cocaine runway, females1.11.11.50.6-0.70.71.11.21.1-1.01.21.11.21.01.01.2
Run reversals in cocaine runway, males0.30.30.80.3-0.10.1-0.0-0.6-0.50.6-0.5-0.8-0.4-0.5-0.9-0.6
Latency to leave start box in cocaine runway0.40.51.2-0.20.8-0.8-1.0-0.9-0.70.3-0.5-0.2-1.1-0.9-0.3-0.5
Latency to leave start box in cocaine runway, F0.50.51.1-0.10.3-0.3-0.8-1.0-0.70.8-0.8-0.4-1.1-0.9-0.8-0.8
Latency to leave start box in cocaine runway, M0.30.20.8-0.30.9-0.9-0.7-0.2-0.3-0.40.0-0.0-0.4-0.40.50.2
Std. dev. time between licks in bursts1.31.75.32.3-1.51.52.01.61.3-0.10.90.80.81.20.10.6
Total sessions with >9 infusions0.20.31.6-1.30.3-0.30.50.1-0.00.10.0-0.11.00.7-0.10.2
Short access day 1 total inactive lever presses1.21.63.8-0.90.4-0.40.31.01.1-1.51.41.51.91.41.61.7
Short access day 10 total inactive lever presses0.30.84.5-2.1-1.01.00.2-0.1-0.90.3-1.1-0.7-0.6-0.3-0.7-0.8
Short access day 1 total infusions0.20.31.2-0.9-0.00.00.60.50.3-0.30.30.21.10.90.20.5
Short access day 10 total infusions0.40.61.8-0.1-0.00.00.70.70.9-0.40.80.81.31.30.30.8
Short access total infusions0.50.61.7-1.21.0-1.0-0.20.20.4-0.70.60.51.30.90.70.8
Short access day 1 locomotion0.20.20.9-0.1-0.60.60.80.30.3-0.00.20.30.90.7-0.40.3
Short access day 10 total locomotion0.10.20.80.9-0.70.70.50.40.4-0.10.30.40.20.1-0.20.2
Short access total locomotion0.60.72.00.6-0.90.91.40.90.9-0.10.70.81.11.0-0.10.7
One hour access (0.3 mA shock)2.52.911.2-2.33.4-3.4-1.9-1.0-0.2-0.90.60.21.20.31.30.9
Compulsive drug intake0.60.71.9-1.40.7-0.7-0.6-1.0-0.90.8-0.9-0.8-0.8-0.6-0.5-0.7
One hour access (shock baseline)0.91.34.9-0.82.2-2.2-1.2-0.50.2-0.90.80.31.20.31.10.9
Social response proportion1.82.13.71.2-0.10.10.51.51.7-1.91.81.81.51.21.71.7
Social responses1.11.42.8-0.10.9-0.90.20.61.2-1.11.51.41.71.31.41.6
Social time0.20.30.80.4-0.70.70.80.20.10.9-0.1-0.20.30.3-0.6-0.2
Soleus weight0.51.43.4-0.71.8-1.8-0.70.30.8-1.31.11.21.10.81.61.3
Bone: stiffness3.04.87.8-2.62.6-2.6-2.8-2.8-2.31.5-1.9-2.0-2.0-2.0-0.9-1.5
Tibialis anterior weight1.34.58.3-1.90.9-0.9-2.9-2.4-2.51.2-2.5-2.0-2.6-2.5-1.7-2.3
Time to tail flick, vehicle, before self-admin1.91.92.80.9-1.01.01.31.61.7-1.11.51.71.61.71.31.5
Time to tail flick, vehicle, after self-admin3.24.36.4-1.30.1-0.1-1.9-2.2-2.41.9-2.5-2.5-2.2-2.4-2.5-2.5
Time to tail flick, test, before self-admin0.40.41.5-0.71.2-1.2-1.2-0.4-0.1-0.6-0.00.2-0.3-0.30.3-0.0
Time to tail flick, test, after self-admin0.60.73.3-0.7-1.81.80.80.50.00.3-0.40.1-0.10.4-0.4-0.3
Delta time to tail flick, vehicle, before/after SA9.48.913.8-2.41.3-1.3-3.3-3.4-3.72.1-3.4-3.5-3.3-3.7-2.7-3.3
Delta time to tail flick, test, before/after SA0.40.42.0-0.1-1.41.40.90.2-0.10.7-0.4-0.2-0.00.2-0.5-0.2
Tibia length0.20.61.6-1.30.7-0.7-0.4-0.8-1.00.6-0.7-1.0-0.6-0.8-0.2-0.5
Ambulatory time before self-admin0.30.41.51.2-1.21.20.60.10.10.4-0.20.1-0.5-0.2-0.6-0.3
Ambulatory time after self-admin1.21.42.9-0.70.2-0.20.11.21.2-1.71.31.71.31.21.71.5
Bone: tissue strength0.60.61.50.60.1-0.10.90.81.0-0.40.90.70.91.20.50.8
Total heroin consumption0.70.83.8-2.01.1-1.1-1.1-1.0-0.70.1-0.5-0.6-0.1-0.5-0.1-0.2
Bone: trabecular number2.13.48.3-2.82.9-2.9-1.30.00.2-1.71.10.71.50.62.81.8
Bone: trabecular spacing1.31.74.70.4-1.41.40.5-0.4-1.01.3-1.5-1.3-1.4-0.9-2.2-1.7
Bone: trabecular thickness1.51.97.2-2.02.7-2.7-1.5-0.6-0.2-0.90.50.10.5-0.11.40.9
Bone: trabecular tissue density0.40.62.3-1.51.3-1.3-1.3-0.6-0.4-0.5-0.10.2-0.0-0.30.40.2
Water consumed over 24 hours1.31.83.0-1.1-0.40.4-1.1-1.3-1.61.3-1.7-1.6-1.7-1.6-1.1-1.5
Number of responses in last shaping day1.31.43.6-0.50.6-0.61.21.01.1-1.11.31.11.91.70.81.4