Hdac7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Hdac7	0.03	0.03	9.0e-04	0.02	0.02	0.02	0.01	3.9e-03	2.5e-03	5.0e-03	9.2e-03
2	Liver	mRNA stability	Hdac7	0.08	0.08	1.2e-03	0.02	0.01	0.01	0.01	5.1e-03	4.2e-02	1.9e-02	5.5e-02
3	Adipose	mRNA stability	Hdac7	0.2	0.1	0.0e+00	0.16	0.17	0.17	0.17	5.3e-17	6.0e-19	2.6e-18	1.7e-18
4	LHb	gene expression	Hdac7	0.47	0.21	1.5e-05	0.13	0.16	0.12	0.13	4.7e-04	1.3e-04	1.2e-03	6.5e-04
5	Brain	gene expression	Hdac7	0.04	0.04	8.1e-05	0.05	0.04	0.05	0.05	9.7e-06	8.4e-05	3.7e-05	1.4e-05
6	IL	gene expression	Hdac7	0.44	0.21	3.1e-03	0.01	0.07	0.09	0.06	2.0e-01	1.0e-02	3.5e-03	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	8.1	13.6	17.5	-3.7	-3.4	-4.0	3.5	-3.2	4.2
Area under the delay curve	2.0	2.1	2.6	-1.4	-1.3	-1.5	1.5	-1.2	1.6
BMI with tail	5.2	17.0	18.9	-4.2	-4.1	-4.3	4.2	-3.6	4.3
BMI without tail	0.1	0.2	0.5	-0.4	-0.5	-0.5	0.4	-0.3	0.7
Body weight	7.3	30.7	33.1	-5.7	-5.7	-5.8	5.7	-5.1	5.3
Weight adjusted by age	1.8	2.0	3.3	-1.6	-1.8	-1.4	1.4	-1.2	0.8
Bone surface	10.5	18.5	20.2	-4.4	-4.2	-4.5	4.2	-4.1	4.4
Bone volume	6.9	11.7	13.9	-3.5	-3.3	-3.7	3.3	-3.0	3.7
Breakpoint value in progressive ratio session	0.1	0.2	0.3	-0.4	-0.3	-0.4	0.4	-0.6	0.2
Number of licking bursts	0.7	0.8	2.0	0.6	0.5	0.9	-0.9	0.6	-1.4
Context. condit. distance diff. score	0.4	0.5	0.6	-0.7	-0.8	-0.6	0.7	-0.7	0.6
Locomotion velocity, session 1	0.7	0.8	1.5	0.8	0.7	0.9	-0.7	0.9	-1.2
Locomotion distance, session 1	2.1	2.7	3.9	1.8	1.8	1.5	-1.6	2.0	-1.0
Locomotion velocity, session 2	0.1	0.1	0.2	0.4	0.5	0.4	-0.2	0.3	-0.3
Locomotion distance, session 2	1.6	2.2	3.1	1.7	1.7	1.5	-1.4	1.5	-1.0
Locomotion velocity, session 3	2.4	2.8	3.4	1.8	1.8	1.7	-1.6	1.8	-1.2
Locomotion distance, session 3	4.2	4.6	5.7	2.3	2.4	2.2	-2.2	2.1	-1.6
Stereotopy head waving bouts, day 3	0.6	0.7	1.0	-0.9	-1.0	-0.7	0.7	-1.0	0.3
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.5	-0.5	-0.4	0.4	-0.5	-0.0
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	0.1	0.2	-0.2	0.1	-0.1
Locomotion distance, session 7	1.2	1.5	1.7	1.2	1.2	1.3	-1.3	1.3	-1.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.5	-1.0	-1.1	-0.7	0.9	-1.2	0.2
Stereotopy head waving duration, day 7	1.4	1.7	3.0	-1.4	-1.4	-1.1	1.4	-1.7	0.4
Locomotion velocity, session 8	0.2	0.3	0.6	-0.4	-0.4	-0.4	0.7	-0.7	0.4
Locomotion distance, session 8	0.5	0.7	1.2	1.1	1.1	0.9	-0.8	0.8	-0.3
Degree of sensitization distance	0.6	0.6	0.9	-0.9	-1.0	-0.8	0.8	-0.7	0.5
Degree of sensitization stereotypy	0.5	0.5	1.3	-0.7	-0.8	-0.4	0.7	-1.1	-0.2
Conditioned locomotion	0.2	0.3	1.0	0.2	0.0	0.5	-0.5	0.0	-1.0
Cocaine response after cond. corrected	0.5	0.6	2.2	-0.4	-0.2	-0.8	0.8	-0.2	1.5
Cocaine response after cond. not corrected	0.4	0.5	0.9	0.7	0.9	0.4	-0.5	1.0	0.3
Cocaine response before conditioning	7.3	8.9	10.5	2.9	2.9	3.1	-3.2	2.8	-2.9
Saline control response	0.1	0.1	0.3	0.3	0.5	0.3	-0.6	0.2	-0.1
Bone: connectivity density	6.5	10.2	13.3	-3.2	-2.9	-3.4	3.1	-2.8	3.7
Bone: cortical apparent density	0.6	0.8	1.1	0.9	0.9	1.0	-1.0	0.7	-1.1
Bone: cortical area	9.5	14.3	15.4	-3.9	-3.9	-3.9	3.7	-3.6	3.6
Bone: cortical porosity	2.7	2.9	3.6	1.6	1.5	1.7	-1.9	1.7	-1.8
Bone: cortical porosity	3.1	3.3	4.0	1.8	1.7	1.9	-2.0	1.6	-1.9
Bone: cortical thickness	4.2	6.9	7.5	-2.7	-2.7	-2.7	2.5	-2.5	2.7
Bone: cortical thickness	0.4	0.4	1.0	-0.6	-0.6	-0.7	0.5	-0.0	1.0
Bone: cortical tissue density	0.8	1.1	1.4	1.0	1.0	1.1	-1.1	0.9	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	0.3	0.0	-0.1	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.2	-0.4	-0.3	-0.6	0.6	-0.2	1.1
Condit. Reinf. active responses	0.4	0.5	1.0	0.8	0.8	0.6	-0.7	1.0	-0.3
Condit. Reinf. inactive responses	3.1	3.7	4.4	1.9	1.8	1.9	-1.9	2.1	-1.9
Incentive salience index mean	0.1	0.1	0.3	-0.2	-0.1	-0.4	0.2	-0.2	0.6
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.6	-0.5	-0.6	0.4	-0.6	0.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.2	0.1	0.1	0.2	-0.1	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	0.4	0.5	0.4	-0.3	0.8	-0.4
Condit. Reinf. active responses	0.3	0.4	0.6	0.6	0.6	0.7	-0.6	0.6	-0.8
Condit. Reinf. inactive responses	1.2	1.5	2.0	1.2	1.1	1.3	-1.3	1.0	-1.4
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.0
Condit. Reinf. lever reinforcers received	0.6	0.8	0.9	0.9	0.9	0.9	-0.8	0.9	-1.0
Conditioned reinforcement - actives	1.4	1.4	1.7	1.2	1.3	1.3	-1.2	0.9	-1.2
Conditioned reinforcement - inactives	0.8	0.9	1.4	1.1	1.2	0.9	-0.9	1.0	-0.6
Conditioned locomotion	0.4	0.5	1.0	0.6	0.7	0.8	-0.7	0.2	-1.0
Patch foraging indifference point 0 sec	1.4	2.2	2.5	1.6	1.5	1.5	-1.4	1.6	-1.3
Patch foraging indifference point AUC	0.2	0.2	0.6	0.4	0.4	0.5	-0.3	0.2	-0.8
Delay disc. indifference point, 0s delay	1.4	1.5	1.9	-1.3	-1.4	-1.2	1.2	-1.3	0.8
Delay disc. indifference point, 16s delay	1.7	1.7	1.8	-1.4	-1.3	-1.3	1.3	-1.3	1.1
Delay disc. indifference point, 2s delay	0.9	1.0	1.1	-1.1	-1.1	-1.0	1.0	-1.0	0.8
Delay disc. indifference point, 24s delay	1.4	1.3	1.6	-1.2	-1.3	-1.2	1.2	-1.0	1.0
Delay disc. indifference point, 4s delay	0.9	0.9	1.9	-0.8	-0.7	-1.1	1.0	-0.5	1.4
Delay disc. indifference point, 8s delay	4.7	4.9	5.6	-2.1	-2.0	-2.3	2.3	-2.2	2.4
Indifference point function ln k	3.2	4.4	4.9	-2.2	-2.2	-2.2	2.1	-2.0	1.9
Indifference point function log k	3.2	4.4	4.9	-2.2	-2.2	-2.2	2.1	-2.0	1.9
Patch foraging total patch changes 0 sec	1.4	2.2	2.5	1.6	1.5	1.6	-1.4	1.4	-1.4
Patch foraging total patch changes 12 sec	1.4	1.9	2.4	1.4	1.3	1.5	-1.3	1.2	-1.5
Patch foraging total patch changes 18 sec	3.7	4.8	5.9	2.2	2.1	2.3	-2.1	1.9	-2.4
Patch foraging total patch changes 24 sec	1.7	2.1	3.2	1.3	1.2	1.6	-1.3	1.3	-1.8
Patch foraging total patch changes 6 sec	2.3	3.5	3.9	1.9	1.9	1.9	-1.8	2.0	-1.6
Patch foraging time to switch 0 sec	3.1	4.8	5.3	2.3	2.3	2.3	-2.3	1.9	-2.0
Patch foraging water rate 0 sec	4.3	6.9	7.9	-2.7	-2.7	-2.6	2.7	-2.8	2.2
Patch foraging water rate 12 sec	3.4	5.2	6.0	-2.4	-2.5	-2.3	2.2	-2.4	1.9
Patch foraging water rate 18 sec	0.8	1.0	1.3	-1.0	-1.1	-1.0	1.1	-1.0	0.8
Patch foraging water rate 24 sec	3.0	4.2	7.3	-2.1	-2.0	-1.9	2.0	-2.7	1.3
Patch foraging water rate 6 sec	4.5	6.6	7.7	-2.6	-2.6	-2.5	2.6	-2.8	2.2
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.4	-0.7	-0.5	-1.0	0.8	-0.4	1.5
Distance traveled before self-admin	1.4	1.5	2.3	1.2	1.1	1.3	-1.3	1.0	-1.5
Distance traveled after self-admin	0.1	0.1	0.2	0.2	0.5	0.1	-0.1	-0.4	0.1
Extensor digitorum longus weight	5.8	22.6	26.0	-5.0	-5.0	-4.8	5.1	-4.9	3.6
Bone: elastic displacement	4.8	5.4	5.9	2.4	2.4	2.4	-2.4	2.1	-2.2
Bone: elastic work	0.1	0.1	0.2	0.3	0.4	0.4	-0.5	0.2	-0.3
Bone: endosteal estimation	6.6	14.3	16.1	-4.0	-4.0	-3.8	3.9	-4.0	3.0
Bone: endosteal perimeter	6.1	12.6	14.2	-3.8	-3.8	-3.6	3.6	-3.6	2.9
Epididymis fat weight	0.8	2.0	2.3	-1.3	-1.1	-1.4	1.5	-1.5	1.5
Delta time in closed arm before/after self-admin	0.4	0.4	1.3	-0.4	-0.3	-0.7	0.6	-0.2	1.1
Delta time in open arm before/after self-admin	4.1	3.9	4.2	2.0	2.0	2.0	-2.0	1.9	-2.0
Diff in mean of infusions in LGA sessions	1.1	1.2	1.5	-1.1	-1.1	-1.2	1.1	-0.6	1.2
Delay discount exponential model param	1.7	1.8	2.3	1.3	1.2	1.4	-1.4	1.1	-1.5
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.7	-0.7	-0.6	0.7	-0.5	0.2
Active lever presses in extinction session 6	0.5	0.5	0.7	-0.7	-0.6	-0.8	0.8	-0.5	0.8
Bone: final force	10.1	16.3	17.7	-4.1	-4.0	-4.2	4.1	-3.7	4.1
Bone: final moment	10.4	16.8	18.3	-4.2	-4.0	-4.3	4.1	-3.8	4.2
Food consumed during 24 hour testing period	1.8	2.2	3.7	-1.3	-1.2	-1.6	1.5	-1.2	1.9
Glucose	0.0	0.1	0.1	-0.3	-0.4	-0.2	0.1	-0.1	0.1
Heart weight	0.1	0.1	0.3	-0.1	-0.0	-0.3	0.3	0.3	0.5
Delay discount hyperbolic model param	1.6	1.6	2.2	1.2	1.2	1.4	-1.3	1.0	-1.5
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.9	1.1	0.7	-0.7	0.8	-0.2
Intermittent access intake escalation	0.3	0.3	0.8	0.7	0.9	0.5	-0.5	0.6	0.1
Intermittent access intake escalation 2	0.6	0.6	1.2	0.9	1.1	0.7	-0.6	0.8	-0.2
Intermitt. access day 1 inactive lever presses	4.5	4.8	7.6	2.1	1.9	2.3	-2.1	1.8	-2.8
Intermitt. access day 15 inactive lever presses	1.2	1.3	1.9	1.0	1.0	1.1	-1.0	1.4	-1.3
Intermitt. access escalation Index	0.4	0.4	0.6	0.6	0.5	0.7	-0.7	0.4	-0.7
Intermittent access day 1 total infusions	1.2	1.4	1.8	1.2	1.3	1.2	-1.2	1.3	-0.9
Intermittent access day 15 total infusions	2.1	2.4	3.1	1.6	1.8	1.5	-1.5	1.7	-1.1
Intermittent access terminal intake (last 3 days)	2.2	2.4	3.2	1.6	1.8	1.5	-1.5	1.7	-1.1
Intermittent access total infusions	2.2	2.4	3.1	1.6	1.8	1.5	-1.6	1.5	-1.2
Intermittent access day 1 locomotion	1.5	1.6	2.5	1.1	1.1	1.3	-1.3	1.0	-1.6
Intermittent access day 15 total locomotion	1.6	1.7	3.1	1.1	1.1	1.3	-1.3	1.2	-1.8
Intermittent access total locomotion	3.5	4.0	6.8	1.8	1.8	2.1	-2.0	1.4	-2.6
Intermittent access standard deviation	0.5	0.6	1.1	0.7	0.9	0.6	-0.7	1.0	-0.3
Left kidney weight	0.9	2.5	5.5	-1.3	-1.1	-1.7	1.6	-0.8	2.3
Right kidney weight	2.7	7.7	9.4	-3.0	-3.1	-2.9	2.9	-2.1	2.6
Cocaine induced anxiety	1.0	1.2	2.3	-1.1	-1.1	-1.0	1.0	-1.5	0.6
Post-drug Anxiety	4.0	4.4	6.8	-2.1	-2.1	-2.0	2.0	-2.6	1.6
Baseline Anxiety	1.1	1.2	1.6	-1.1	-1.1	-1.2	1.0	-0.8	1.3
Tail length	0.1	0.2	0.2	0.3	0.3	0.4	-0.4	0.4	-0.5
Length with tail	2.0	7.4	8.4	-2.9	-2.9	-2.8	2.8	-2.4	2.5
Length without tail	8.4	18.4	20.2	-4.4	-4.3	-4.5	4.5	-3.9	4.2
Times rat made contact with spout	0.3	0.3	0.6	-0.4	-0.3	-0.6	0.7	-0.5	0.8
Lifetime Intake	1.6	1.8	2.4	1.4	1.6	1.3	-1.4	1.3	-1.0
Liver weight, left	1.9	3.1	3.3	-1.8	-1.7	-1.8	1.7	-1.8	1.8
Liver weight, right	1.7	2.8	3.3	-1.8	-1.8	-1.8	1.7	-1.3	1.7
Locomotor activity	1.0	1.6	1.8	1.2	1.1	1.3	-1.3	1.3	-1.2
Locomotor testing distance	2.8	4.7	5.1	2.2	2.0	2.2	-2.3	2.3	-2.0
Locomotor testing rearing	3.2	5.0	5.5	2.1	2.0	2.3	-2.3	2.3	-2.3
Locomotion in novel chamber	0.6	0.7	1.1	-1.0	-1.1	-0.9	1.0	-0.6	0.5
Locomotion in novel chamber post-restriction	0.6	0.8	1.2	-0.8	-0.9	-0.8	1.0	-1.1	0.5
Fecal boli incidents, locomotor time 1	0.3	0.4	0.9	0.6	0.9	0.1	-0.2	0.3	0.8
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	-0.8	-0.9	-0.7	0.6	-0.1	0.3
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.7	-0.9	-0.8	-1.1	1.0	-1.2	1.3
Bouts of movement, locomotor time 1	0.4	0.4	1.0	-0.5	-0.3	-0.7	0.6	-0.4	1.0
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.0	0.3	-0.2	0.1	0.1	0.6
Rest time, locomotor task time 1	0.1	0.1	0.4	0.2	0.2	0.0	-0.1	0.7	0.3
Distance moved, locomotor task time 1	0.2	0.2	0.5	0.4	0.4	0.5	-0.4	-0.2	-0.7
Vertical activity count, locomotor time 1	1.6	1.7	2.4	-1.2	-1.1	-1.3	1.3	-1.3	1.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.5	0.4	0.4	-0.4	0.3	-0.3
Bouts of movement, locomotor time 2	2.6	2.8	3.6	-1.8	-1.8	-1.6	1.8	-1.9	1.0
Total resting periods, locomotor time 2	2.7	2.9	3.6	-1.9	-1.8	-1.7	1.8	-1.9	1.0
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.5	-0.4	-0.6	0.5	-0.0	0.7
Distance moved, locomotor task time 2	0.4	0.4	0.6	0.7	0.6	0.7	-0.7	0.4	-0.8
Vertical activity count, locomotor time 2	0.2	0.2	0.2	-0.4	-0.5	-0.4	0.5	-0.5	0.2
Light reinforcement 1	3.6	6.6	8.7	2.4	2.4	2.7	-2.7	2.1	-2.9
Light reinforcement 2	0.9	1.3	1.4	1.1	1.1	1.1	-1.2	1.2	-1.0
Bone: marrow area	6.6	14.4	16.3	-4.0	-4.0	-3.8	3.9	-4.0	2.9
Bone: maximum diameter	4.2	7.7	9.3	-3.0	-3.0	-2.8	2.8	-2.6	2.4
Bone: maximum force	12.0	20.7	22.5	-4.7	-4.7	-4.7	4.6	-4.3	4.3
Bone: maximum moment	12.2	21.0	22.5	-4.7	-4.7	-4.7	4.6	-4.3	4.4
Mean time between licks in bursts	0.4	0.6	0.9	0.8	0.9	0.8	-0.9	0.6	-0.7
Mean num. licks in bursts	0.6	0.7	2.5	-0.4	-0.2	-0.8	0.9	-0.5	1.6
Cd content in liver	0.2	0.2	0.3	0.5	0.4	0.5	-0.5	0.6	-0.3
Co content in liver	0.2	0.2	0.4	0.5	0.3	0.4	-0.7	0.4	-0.4
Cu content in liver	1.5	1.8	2.0	-1.4	-1.4	-1.4	1.4	-1.3	1.3
Fe content in liver	0.1	0.1	0.1	0.3	0.2	0.3	-0.4	0.4	-0.2
K content in liver	1.9	1.8	2.5	-1.3	-1.5	-1.4	1.6	-1.0	1.4
Mg content in liver	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.3	0.1	0.5
Mn content in liver	0.1	0.1	0.3	-0.4	-0.6	-0.3	0.5	-0.2	-0.0
Na content in liver	0.1	0.2	0.3	-0.4	-0.6	-0.3	0.6	-0.2	-0.0
Rb content in liver	0.0	0.1	0.2	0.2	0.1	0.2	-0.2	0.3	-0.4
Se content in liver	0.2	0.3	0.7	0.5	0.5	0.4	-0.4	0.8	-0.1
Sr content in liver	0.9	0.8	0.9	-0.9	-0.9	-0.9	0.9	-1.0	0.8
Zn content in liver	0.6	0.6	1.5	0.7	0.6	0.8	-0.6	0.7	-1.2
Bone: minimum diameter	6.7	12.6	14.5	-3.8	-3.8	-3.6	3.4	-3.6	3.0
Time in familiar zone, hab. session 1	0.1	0.1	0.5	0.3	0.4	0.2	-0.1	0.7	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.2	-0.5	-0.6
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.6	0.6	0.7	-0.6	0.3	-0.8
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.2	0.3	0.1	-0.1	-0.3	-0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	0.2	0.0	-0.1	-0.3	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.7	-0.3	-0.1	-0.5	0.2	-0.0	0.8
Time in novel zone, hab. session 2	0.4	0.4	1.8	0.3	0.1	0.6	-0.3	0.0	-1.3
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.2	0.2	0.0	0.0	0.2	0.3
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	0.4	0.2	-0.2	0.4	0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.1	0.4
Novel to familiar place preference ratio	0.6	0.6	1.1	-1.0	-1.0	-0.7	0.6	-0.7	0.4
Novelty place preference	0.3	0.3	0.6	-0.7	-0.7	-0.4	0.2	-0.5	0.1
Time in novel zone, NPP test	0.1	0.1	0.4	-0.5	-0.6	-0.2	0.0	-0.4	-0.1
Total zone transitions, NPP test	0.6	0.8	1.3	1.1	1.1	0.8	-0.9	1.0	-0.3
Total locomotion distance, NPP test	1.9	2.6	3.5	1.8	1.9	1.6	-1.7	1.6	-1.1
Locomotion velocity, NPP test	0.9	1.3	1.9	1.3	1.4	1.0	-1.2	1.2	-0.6
Intraocular pressure	10.5	14.6	17.7	3.9	4.0	4.0	-4.2	3.1	-3.5
Delta distance traveled before/after self-admin	0.5	0.6	1.4	-0.5	-0.3	-0.8	0.7	-0.8	1.2
Delta ambulatory time before/after self-admin	0.3	0.4	0.7	-0.4	-0.2	-0.5	0.5	-0.8	0.8
Parametrial fat weight	0.5	1.1	1.7	1.3	1.3	1.1	-0.9	0.5	-0.7
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.3	0.0	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.0	0.0	-0.2	0.0	-0.1	0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.1	-0.1	0.4
Pavlov. Cond. index score	0.2	0.2	0.4	-0.3	-0.3	-0.4	0.2	-0.6	0.6
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.2	-0.2	-0.3	0.1	-0.5	0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.5	0.6	0.7	0.5	-0.7	0.3	-0.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	-0.0	-0.0	0.1	-0.0	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	0.7	0.9	0.6	-0.6	1.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	-0.7	-0.7	-0.8	0.7	-1.0	1.0
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	0.3	-0.0	-0.2	-0.1	0.5
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.2	-0.4	-0.2	0.3	0.0	0.1
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.6	-0.4	-0.6	0.3	-0.2	0.5
Pavlov. Cond. change in total contacts	0.9	1.2	2.1	-1.1	-0.8	-1.2	0.9	-1.0	1.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	-0.4	0.5
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.5	-0.3	-0.6	0.3	-0.5	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.6	0.8	0.5	-0.7	0.3	-0.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.4	1.2	1.1	1.1	-0.8	0.9	-0.8
Pavlov. Cond. intertrial magazine entries	1.9	2.4	3.3	1.8	1.7	1.7	-1.3	1.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	-0.4	-0.6	0.3	-0.6	0.6
Pavlov. Cond. response bias	0.1	0.2	0.4	0.4	0.6	0.4	-0.6	0.3	-0.2
Time in closed arm before self-admin	0.5	0.6	1.0	-0.9	-1.0	-0.7	0.7	-0.9	0.0
Time in closed arm after self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.5	0.5	-0.2	0.4
Time in open arm before self-admin	0.8	0.9	1.2	-1.0	-1.1	-1.0	0.9	-0.6	0.9
Time in open arm after self-admin	0.4	0.4	0.9	0.5	0.5	0.6	-0.6	1.0	-0.6
Bone: periosteal estimation	10.9	22.6	24.7	-5.0	-5.0	-4.8	4.8	-4.8	4.2
Bone: periosteal perimeter	10.7	17.9	18.9	-4.4	-4.3	-4.3	4.3	-4.1	3.9
Bone: post-yield work	7.1	9.7	11.9	-3.3	-3.4	-3.0	3.2	-3.4	2.1
Progressive ratio test 1 active lever presses	3.6	3.7	4.1	1.9	2.0	2.0	-2.0	1.7	-1.9
Progressive ratio test 1 breakpoint	3.3	3.5	3.7	1.8	1.9	1.9	-1.9	1.7	-1.9
Progressive ratio test 1 inactive lever presses	2.6	2.8	3.5	1.6	1.6	1.7	-1.5	1.7	-1.9
Progressive ratio test 2 active lever presses	2.1	2.2	2.8	1.4	1.4	1.5	-1.5	1.4	-1.7
Progressive ratio test 2 breakpoint	2.7	3.0	3.8	1.7	1.7	1.8	-1.7	1.6	-1.9
Progressive ratio test 2 inactive lever presses	3.1	3.6	3.9	1.9	1.8	2.0	-1.9	1.9	-2.0
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.2	0.2	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.2	-0.0	-0.1	0.0	-0.0	0.4	-0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.4	0.5	0.4	-0.4	0.3	-0.4
Progressive ratio	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3	0.2	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.1	-0.0	-0.1	0.3	-0.6	0.2
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	-0.0	0.0	0.1	-0.1	-0.5	-0.2
Retroperitoneal fat weight	0.0	0.1	0.3	0.2	0.5	-0.1	0.3	0.3	0.6
Reaction time number correct	0.5	0.8	1.8	-0.8	-0.8	-0.8	0.7	-1.3	0.7
Reaction time mean minus median	7.4	9.9	12.5	3.4	3.5	3.0	-3.2	3.5	-2.0
Reaction time mean minus median AUC	5.5	7.1	9.5	2.9	3.1	2.5	-2.7	2.9	-1.7
Reaction time num false alarms	1.7	2.3	2.5	1.6	1.6	1.5	-1.4	1.6	-1.3
Reaction time num false alarms AUC	2.6	3.6	4.4	2.0	2.1	1.9	-1.8	2.1	-1.4
Reaction time trials correct on left	0.5	0.8	1.8	-0.8	-0.8	-0.8	0.7	-1.3	0.7
Reaction time trials on left	0.4	0.5	1.4	-0.7	-0.6	-0.6	0.6	-1.2	0.5
Reaction time mean	0.6	0.8	1.4	0.9	1.2	0.7	-1.0	0.9	-0.2
Reaction time mean AUC	0.3	0.4	0.9	0.7	0.9	0.5	-0.7	0.6	0.1
Median of all reaction times	0.0	0.0	0.2	-0.0	0.2	-0.1	-0.1	-0.1	0.4
Reaction time omissions	8.9	12.1	14.4	3.6	3.8	3.4	-3.5	3.6	-2.8
Reaction time false alarm rate	2.1	2.9	4.4	1.8	1.8	1.6	-1.6	2.1	-1.3
Reaction time premature initiation rate	4.1	5.4	6.7	2.4	2.3	2.5	-2.2	2.0	-2.6
Reaction time premature initiations	2.4	3.4	4.6	1.9	1.9	2.0	-1.8	1.3	-2.1
Std. dev. reaction times	5.6	7.9	10.3	3.0	3.2	2.6	-2.9	3.1	-1.8
Reaction time trials completed	0.4	0.5	1.4	-0.7	-0.6	-0.6	0.6	-1.2	0.5
Reaction time trials AUC	0.8	1.1	2.3	-1.0	-1.0	-0.9	0.9	-1.5	0.8
Run reversals in cocaine runway, females	0.5	0.5	0.9	0.6	0.4	0.7	-0.8	1.0	-0.7
Run reversals in cocaine runway, males	1.2	1.2	1.5	1.1	1.0	1.1	-1.0	1.1	-1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	0.0	0.1	-0.1	0.1	-0.4
Latency to leave start box in cocaine runway, F	2.2	2.4	3.2	1.5	1.4	1.6	-1.6	1.5	-1.8
Latency to leave start box in cocaine runway, M	2.7	2.6	3.0	-1.6	-1.5	-1.6	1.7	-1.7	1.5
Std. dev. time between licks in bursts	1.3	1.5	2.0	1.2	1.2	1.3	-1.3	0.9	-1.4
Total sessions with >9 infusions	0.3	0.4	0.6	0.6	0.7	0.5	-0.6	0.8	-0.3
Short access day 1 total inactive lever presses	0.7	0.8	1.1	0.9	1.0	0.9	-0.8	0.6	-0.8
Short access day 10 total inactive lever presses	0.8	0.8	2.4	0.7	0.7	1.0	-0.7	0.4	-1.5
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.2	0.2	0.4
Short access day 10 total infusions	0.4	0.4	0.8	0.7	0.9	0.6	-0.7	0.7	-0.2
Short access total infusions	0.1	0.1	0.2	0.3	0.5	0.3	-0.4	0.4	-0.2
Short access day 1 locomotion	0.1	0.1	0.5	-0.0	-0.1	0.1	-0.2	0.7	-0.4
Short access day 10 total locomotion	0.6	0.7	2.6	0.5	0.4	0.9	-0.8	0.2	-1.6
Short access total locomotion	0.5	0.5	1.5	0.5	0.5	0.7	-0.7	0.3	-1.2
One hour access (0.3 mA shock)	0.2	0.2	0.7	0.4	0.5	0.3	-0.3	0.8	-0.2
Compulsive drug intake	0.7	0.7	1.1	-0.8	-0.8	-0.9	0.8	-0.7	1.0
One hour access (shock baseline)	0.0	0.0	0.3	0.0	0.1	0.0	-0.1	0.5	-0.0
Social response proportion	0.6	0.6	1.5	0.7	0.6	0.7	-0.9	1.2	-0.3
Social responses	9.1	11.7	13.7	3.4	3.1	3.5	-3.4	3.7	-3.3
Social time	0.7	0.9	2.3	0.8	0.9	0.6	-1.1	1.5	0.3
Soleus weight	1.0	2.8	3.6	-1.7	-1.9	-1.6	1.9	-1.7	1.1
Bone: stiffness	14.7	23.3	25.5	-5.0	-5.0	-5.0	4.8	-4.6	4.5
Tibialis anterior weight	2.2	7.5	9.8	-2.9	-3.1	-2.6	3.0	-2.9	1.6
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.3	1.1	1.1	1.0	-0.9	0.9	-0.8
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.0	-0.1	0.3	-0.4	0.6	-0.7
Time to tail flick, test, before self-admin	0.8	0.8	1.5	0.8	0.8	0.8	-0.9	1.2	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.3	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	-0.5	-0.3	0.2	-0.2	0.2
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	-0.6	-0.7	-0.6	0.6	-0.7	0.4
Tibia length	5.4	15.4	17.2	-4.1	-4.0	-4.0	3.7	-4.1	3.5
Ambulatory time before self-admin	4.5	4.6	5.3	2.1	2.1	2.3	-2.2	1.9	-2.3
Ambulatory time after self-admin	1.3	1.4	1.8	1.3	1.3	1.3	-1.2	0.6	-1.3
Bone: tissue strength	0.2	0.2	0.4	-0.6	-0.4	-0.5	0.4	-0.6	0.4
Total heroin consumption	1.9	2.3	3.9	-1.6	-1.7	-1.3	1.5	-2.0	0.5
Bone: trabecular number	5.2	8.2	13.3	-2.8	-2.4	-3.1	2.8	-2.3	3.6
Bone: trabecular spacing	1.8	2.4	5.0	1.4	1.1	1.7	-1.4	1.2	-2.2
Bone: trabecular thickness	0.3	0.4	0.9	0.5	0.7	0.2	-0.6	0.9	0.4
Bone: trabecular tissue density	0.2	0.3	0.6	0.4	0.5	0.6	-0.6	0.3	-0.8
Water consumed over 24 hours	0.2	0.3	0.5	-0.4	-0.5	-0.5	0.7	-0.4	0.6
Number of responses in last shaping day	0.2	0.2	0.4	-0.6	-0.6	-0.5	0.5	-0.3	-0.0