Hub : Genes

H2az2

H2A.Z variant histone 2

chr14:85507228–85526166 (-)

H2az2 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	H2az2	0.07	0.05	9.2e-04	0.03	0.01	0.01	0.02	6.8e-04	1.3e-02	1.6e-02	5.5e-03
2	Liver	isoform ratio	XM_039092453.2	0.07	0.04	2.1e-05	0.04	0.04	0.03	0.03	2.8e-05	3.3e-05	1.4e-04	3.2e-04
3	IL	gene expression	H2az2	0.18	0.12	9.7e-03	0.01	0.01	0.03	0.01	1.6e-01	1.4e-01	5.7e-02	1.6e-01
4	PL	mRNA stability	H2az2	0.03	0.02	1.4e-03	0.03	0.02	0	0.02	3.0e-04	2.5e-03	9.5e-02	1.3e-03
5	NAcc	mRNA stability	H2az2	0.06	0.04	2.5e-06	0.04	0.04	0.04	0.04	2.3e-07	4.8e-06	9.8e-07	1.1e-06
6	Brain	mRNA stability	H2az2	0.31	0.22	4.2e-12	0.15	0.11	0.12	0.14	1.1e-13	1.8e-10	4.3e-11	5.8e-13
7	pVTA	mRNA stability	H2az2	0.13	0.09	7.5e-05	0.04	0.04	0.04	0.05	2.2e-04	3.0e-04	6.6e-04	5.4e-05
8	Brain	gene expression	H2az2	0.05	0.03	7.3e-03	0.01	0.02	0.03	0.02	2.9e-02	2.5e-03	4.7e-04	9.2e-03
9	Liver	isoform ratio	XM_017599381.3	0.02	0.01	9.1e-03	0.01	0.01	0.01	0.01	1.3e-02	1.4e-02	7.1e-02	1.7e-02
10	RMTg	intron excision ratio	chr14_85509589_85514289	0.32	0.15	1.9e-03	0.11	0.05	0.08	0.11	9.3e-04	2.0e-02	4.3e-03	6.4e-04
11	RMTg	intron excision ratio	chr14_85514402_85520891	0.3	0.23	5.0e-03	-0.01	0.01	-0.01	0.01	9.9e-01	1.3e-01	9.4e-01	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.0	0.0	0.1	0.3	0.4	0.2	-0.2	-0.1	-0.0	-0.2	-0.0	0.3	-0.0	-0.0
Area under the delay curve	4.0	4.6	10.8	-1.6	-2.0	-1.9	3.3	2.5	2.5	2.2	0.6	2.1	-1.3	2.4
BMI with tail	0.2	0.6	3.0	-0.9	-0.9	-1.7	0.9	0.2	0.2	0.7	0.1	-0.2	-0.2	0.7
BMI without tail	0.3	1.0	1.9	-1.2	-1.3	-1.1	0.9	1.2	1.0	1.4	-0.4	0.5	-0.5	0.7
Body weight	1.4	6.0	9.1	-2.7	-3.0	-3.0	2.7	2.7	2.6	2.8	-1.2	2.5	-0.8	1.7
Weight adjusted by age	0.2	0.4	0.8	-0.5	-0.4	-0.7	0.8	0.7	0.6	0.5	0.3	0.6	-0.3	0.9
Bone surface	0.1	0.2	0.4	-0.4	-0.2	-0.4	0.1	0.4	0.3	-0.0	-0.6	0.6	0.6	-0.4
Bone volume	0.1	0.2	0.6	-0.5	-0.3	-0.6	0.3	0.5	0.4	0.1	-0.7	0.8	0.5	-0.2
Breakpoint value in progressive ratio session	0.2	0.3	1.3	-0.5	-0.2	-0.4	0.6	0.3	0.4	0.4	-0.7	1.1	-0.0	0.1
Number of licking bursts	2.0	3.3	6.1	-1.7	-1.7	-2.2	2.5	2.2	2.1	1.4	-1.5	2.1	0.3	0.9
Context. condit. distance diff. score	1.7	2.1	4.1	1.8	1.8	1.1	-1.2	-1.7	-1.7	-2.0	1.0	-1.3	0.6	-0.9
Locomotion velocity, session 1	0.6	0.6	2.2	0.2	0.7	1.5	-1.2	-0.5	-0.6	-0.7	0.1	-0.7	0.6	-1.1
Locomotion distance, session 1	0.9	1.2	3.6	0.9	0.3	1.9	-0.3	0.3	0.2	0.6	1.4	0.7	-1.9	1.4
Locomotion velocity, session 2	1.3	1.5	5.1	-0.2	0.6	1.5	-1.5	-0.8	-0.8	-1.1	-0.8	-0.6	1.7	-2.3
Locomotion distance, session 2	0.9	1.2	4.4	1.1	1.0	2.1	-1.7	-0.8	-0.9	-0.4	0.8	-0.9	-0.7	-0.1
Locomotion velocity, session 3	0.9	1.1	3.0	1.4	1.0	1.7	-1.0	-1.0	-1.0	-1.1	0.9	-0.7	-0.3	-0.1
Locomotion distance, session 3	0.3	0.3	1.2	-0.8	-1.1	-0.3	0.7	0.6	0.6	0.5	-0.5	0.5	0.2	-0.1
Stereotopy head waving bouts, day 3	0.6	0.7	3.6	0.7	0.7	1.9	-1.2	-0.5	-0.6	-0.3	0.2	-0.2	-0.3	-0.5
Stereotopy head waving duration, day 3	2.0	2.3	5.5	1.6	1.9	2.4	-2.1	-1.6	-1.6	-1.4	0.7	-1.2	-0.0	-1.0
Locomotion velocity, session 7	0.2	0.2	0.7	-0.5	-0.4	0.2	0.1	0.4	0.4	0.2	-0.8	0.4	0.2	-0.4
Locomotion distance, session 7	0.1	0.1	0.2	0.3	0.4	0.0	-0.0	-0.1	-0.2	-0.4	-0.1	-0.0	0.3	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.3	0.3	0.2	0.1	-0.3	-0.2	-0.6	0.3	-0.2	0.5	-0.1
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.3	0.2	0.5	-0.1	-0.1	0.0	-0.2	0.4	-0.0	-0.1	0.3
Locomotion velocity, session 8	1.3	1.5	2.8	1.0	1.2	1.7	-1.5	-1.0	-1.0	-1.7	0.5	-0.6	1.1	-1.6
Locomotion distance, session 8	4.4	6.4	9.7	3.0	2.9	3.1	-3.0	-2.7	-2.8	-2.6	2.0	-2.5	0.1	-1.2
Degree of sensitization distance	1.9	2.0	4.9	1.7	2.2	1.0	-1.4	-1.4	-1.5	-1.9	0.8	-1.2	0.5	-0.9
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.4	0.1	0.2	-0.2	0.2	0.1	0.3	0.3
Conditioned locomotion	0.7	0.8	3.6	1.0	0.2	1.1	-0.2	0.3	0.4	0.4	1.0	0.5	-1.9	1.4
Cocaine response after cond. corrected	1.2	1.4	3.4	-1.2	-1.3	-0.9	1.5	1.5	1.6	1.0	-0.8	1.8	0.3	0.4
Cocaine response after cond. not corrected	1.7	2.0	4.3	-1.3	-1.4	-1.2	1.9	1.6	1.7	1.2	-1.0	2.1	-0.0	0.8
Cocaine response before conditioning	0.1	0.2	0.4	0.7	0.4	0.0	0.1	-0.3	-0.3	-0.2	0.3	-0.3	-0.6	0.7
Saline control response	0.2	0.3	0.7	0.3	0.4	0.6	-0.8	-0.5	-0.5	-0.7	0.0	-0.4	0.5	-0.7
Bone: connectivity density	0.1	0.2	0.5	0.5	0.7	0.4	-0.4	-0.6	-0.7	-0.5	-0.0	-0.2	0.2	-0.4
Bone: cortical apparent density	0.2	0.3	0.8	-0.9	-0.8	-0.7	0.8	0.5	0.5	0.6	-0.4	0.1	0.3	0.1
Bone: cortical area	1.6	2.5	4.4	-1.7	-2.0	-1.6	1.6	1.7	1.6	1.9	-1.0	2.1	-0.6	1.1
Bone: cortical porosity	0.0	0.0	0.2	-0.1	0.4	0.4	-0.4	-0.0	0.1	0.0	0.0	0.0	-0.0	-0.3
Bone: cortical porosity	0.1	0.1	0.4	0.4	0.6	0.3	-0.2	-0.1	-0.0	-0.1	0.5	-0.0	-0.4	0.3
Bone: cortical thickness	1.3	2.1	3.9	-1.4	-1.6	-1.3	1.6	1.5	1.5	1.8	-0.7	2.0	-0.9	1.2
Bone: cortical thickness	0.5	0.6	1.9	0.9	0.7	-0.1	0.8	0.3	0.4	-0.1	1.0	0.7	-1.2	1.4
Bone: cortical tissue density	0.3	0.4	0.9	-1.0	-0.8	-0.8	0.9	0.5	0.5	0.6	-0.5	0.1	0.4	0.0
Condit. Reinf. active minus inactive responses	0.8	0.9	3.1	-1.5	-0.9	-0.7	0.6	0.8	0.8	0.5	-1.8	0.4	1.1	-0.8
Condit. Reinf. active-inactive response ratio	1.2	1.3	4.1	-0.5	0.5	-0.5	-0.5	-0.9	-0.9	-1.1	-1.3	-0.8	2.0	-1.9
Condit. Reinf. active responses	0.5	0.6	2.0	-1.1	-0.7	-0.2	0.5	1.0	1.0	0.6	-1.4	0.5	0.4	-0.3
Condit. Reinf. inactive responses	0.8	1.0	2.3	-0.5	-0.9	-0.1	0.9	1.5	1.5	1.1	-0.3	1.2	-0.9	1.1
Incentive salience index mean	1.4	1.7	3.0	-1.7	-1.5	-0.9	1.2	1.6	1.6	1.3	-1.7	1.2	0.3	0.1
Condit. Reinf. lever presses	1.3	1.8	3.4	-0.8	-1.4	-0.0	1.0	1.8	1.8	1.8	-0.5	1.4	-1.3	1.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.6	0.6	0.6	-0.7	-0.2	-0.2	-0.5	0.4	-0.2	-0.2	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.2	-0.3	-0.1	0.3	0.7	0.6	0.4	0.3	0.6	-0.4	0.5
Condit. Reinf. active responses	0.4	0.6	1.5	0.9	0.8	1.1	-1.2	-0.6	-0.7	-0.6	0.4	-0.7	-0.2	-0.3
Condit. Reinf. inactive responses	1.1	1.4	2.7	1.1	1.3	1.2	-1.6	-1.4	-1.4	-1.3	0.1	-1.3	0.4	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.5	0.7	0.6	0.6	-0.3	-0.1	-0.1	-0.5	0.4	0.1	-0.1	0.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.9	0.7	0.7	0.9	-1.0	-0.3	-0.4	-0.5	0.2	-0.2	-0.2	-0.3
Conditioned reinforcement - actives	0.1	0.1	0.7	-0.3	-0.0	-0.2	-0.1	0.2	0.1	0.2	-0.9	-0.3	-0.2	-0.1
Conditioned reinforcement - inactives	0.2	0.3	0.9	-0.6	-0.4	-0.7	0.6	0.7	0.7	0.5	-1.0	0.0	-0.0	0.3
Conditioned locomotion	0.6	0.8	2.2	-1.2	-1.0	-0.3	0.2	1.1	1.0	1.2	-1.5	0.2	-0.5	0.0
Patch foraging indifference point 0 sec	2.0	3.6	7.7	-2.1	-1.5	-2.8	1.8	1.3	1.3	0.6	-2.5	2.7	2.0	-1.1
Patch foraging indifference point AUC	0.2	0.3	1.3	-0.4	0.0	0.2	-0.3	0.3	0.4	-0.2	-1.1	0.1	0.7	-0.9
Delay disc. indifference point, 0s delay	2.5	2.7	9.5	-0.8	-1.1	-2.9	3.1	1.1	1.2	0.9	0.1	1.7	-0.4	2.0
Delay disc. indifference point, 16s delay	1.3	1.5	3.0	-1.3	-1.6	-1.2	1.7	1.4	1.4	1.5	0.2	0.6	-0.4	0.9
Delay disc. indifference point, 2s delay	3.5	3.9	8.8	-1.1	-1.0	-1.8	3.0	2.1	2.1	1.8	-0.0	2.4	-1.6	2.7
Delay disc. indifference point, 24s delay	1.5	1.6	2.9	-1.1	-1.7	-1.4	1.6	1.5	1.3	1.4	0.8	0.7	-0.5	1.3
Delay disc. indifference point, 4s delay	4.6	4.8	10.6	-1.7	-1.5	-1.8	3.2	2.6	2.7	2.2	-0.1	2.4	-1.5	2.6
Delay disc. indifference point, 8s delay	1.8	2.1	3.3	-0.8	-1.6	-0.3	1.8	1.7	1.7	1.5	1.3	1.2	-1.4	1.7
Indifference point function ln k	0.2	0.3	1.1	0.1	-0.2	-0.0	0.5	0.3	0.3	0.6	0.3	0.5	-1.0	1.1
Indifference point function log k	0.2	0.3	1.1	0.1	-0.2	-0.0	0.5	0.3	0.3	0.6	0.3	0.5	-1.0	1.1
Patch foraging total patch changes 0 sec	2.1	4.0	8.0	-2.2	-1.5	-2.8	1.7	1.4	1.3	0.5	-2.8	2.7	2.2	-1.4
Patch foraging total patch changes 12 sec	1.5	2.0	4.6	-1.6	-0.8	-2.0	1.0	0.5	0.7	0.2	-2.1	1.6	1.8	-1.4
Patch foraging total patch changes 18 sec	1.9	3.0	6.0	-2.0	-1.3	-2.4	0.9	1.1	1.1	0.0	-2.0	2.1	2.5	-1.8
Patch foraging total patch changes 24 sec	0.9	1.6	5.1	0.4	1.0	-0.7	-0.5	-1.0	-1.0	-1.9	-0.2	-0.3	2.3	-2.1
Patch foraging total patch changes 6 sec	2.0	3.1	7.5	-2.2	-1.3	-2.2	1.2	1.2	1.2	0.7	-2.7	1.9	2.0	-1.4
Patch foraging time to switch 0 sec	0.2	0.5	1.3	0.9	0.5	0.3	-0.4	-0.7	-0.6	-0.2	1.1	-0.6	-0.9	0.6
Patch foraging water rate 0 sec	0.9	2.0	4.5	-2.0	-1.5	-1.3	0.7	1.1	1.1	0.8	-2.1	1.2	1.7	-1.2
Patch foraging water rate 12 sec	0.1	0.1	0.4	-0.4	-0.5	-0.1	0.2	0.6	0.5	0.2	0.4	0.1	0.4	-0.1
Patch foraging water rate 18 sec	0.8	1.2	4.9	0.4	-0.4	0.3	0.5	0.6	0.5	1.1	1.1	0.5	-2.2	1.9
Patch foraging water rate 24 sec	0.1	0.2	0.7	-0.2	-0.4	0.4	-0.8	0.1	0.0	0.2	0.1	-0.8	-0.1	-0.3
Patch foraging water rate 6 sec	0.4	0.6	1.3	-0.6	-1.1	0.8	-0.2	1.1	1.1	1.0	0.1	0.0	-0.9	0.7
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	3.8	0.1	0.0	1.5	-0.9	0.3	0.2	0.7	-0.1	-0.5	-2.0	0.7
Distance traveled before self-admin	0.1	0.1	0.4	-0.2	-0.5	-0.3	0.0	0.1	0.1	-0.0	-0.6	-0.5	0.6	0.0
Distance traveled after self-admin	0.2	0.2	1.0	-0.2	-0.4	-0.0	0.3	0.4	0.5	0.4	0.7	-0.1	-0.6	1.0
Extensor digitorum longus weight	1.8	7.2	12.6	-3.6	-3.4	-2.4	2.2	2.8	2.9	3.0	-3.0	3.1	0.2	0.0
Bone: elastic displacement	0.6	0.7	1.8	0.8	1.0	0.7	-1.0	-1.3	-1.3	-0.7	0.1	-0.9	0.0	-0.3
Bone: elastic work	0.2	0.2	0.9	-0.1	-0.3	0.1	0.3	0.3	0.3	0.7	-0.2	0.9	-0.7	0.6
Bone: endosteal estimation	0.0	0.1	0.3	-0.1	-0.3	-0.3	-0.0	0.5	0.4	0.0	-0.1	0.6	0.2	0.1
Bone: endosteal perimeter	0.7	1.5	2.4	-0.7	-1.5	-1.2	1.1	1.5	1.4	1.3	-0.2	1.5	-0.8	1.2
Epididymis fat weight	0.4	1.3	3.5	-1.3	-1.4	-1.9	1.0	0.8	0.9	1.2	-1.1	1.4	-0.2	0.6
Delta time in closed arm before/after self-admin	7.6	7.1	11.6	3.1	2.7	3.1	-2.6	-2.6	-2.7	-2.2	3.4	-2.9	-2.2	0.8
Delta time in open arm before/after self-admin	5.6	5.5	13.3	-2.7	-2.8	-2.9	2.0	2.0	2.1	1.9	-3.6	1.9	1.8	-0.7
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	0.2	0.3	-0.2	0.3	-0.2	-0.2	0.1	0.8	0.3	-1.0	1.0
Delay discount exponential model param	4.1	4.5	10.4	1.6	2.0	1.9	-3.2	-2.5	-2.6	-2.1	-0.7	-2.1	1.2	-2.3
Extinction: sum of active levers before priming	0.1	0.1	0.6	-0.2	-0.3	-0.1	-0.3	-0.0	-0.0	0.1	-0.8	-0.7	0.1	-0.3
Active lever presses in extinction session 6	0.6	0.6	2.4	0.6	0.5	0.7	0.2	-0.5	-0.3	-0.1	0.8	0.5	-1.6	1.1
Bone: final force	0.2	0.3	0.9	-1.0	-0.5	-0.5	-0.2	0.3	0.2	0.3	-0.7	0.4	0.6	-0.5
Bone: final moment	0.2	0.4	1.3	-1.1	-0.7	-0.7	-0.0	0.4	0.4	0.5	-0.7	0.5	0.5	-0.4
Food consumed during 24 hour testing period	0.7	1.0	3.0	-1.7	-1.0	-0.7	0.2	0.9	0.9	0.6	-0.9	0.6	1.2	-1.3
Glucose	6.5	10.3	29.4	-5.4	-3.0	-2.7	0.6	1.6	1.6	0.9	-3.8	0.2	5.1	-4.6
Heart weight	0.6	1.0	3.8	-0.9	-0.1	-1.3	-0.3	-0.4	-0.4	-0.5	-1.4	-0.1	1.9	-1.5
Delay discount hyperbolic model param	4.4	4.8	10.7	1.6	2.0	1.8	-3.3	-2.6	-2.7	-2.2	-0.7	-2.3	1.4	-2.5
Intermittent access intake day 1-15 change	0.7	1.4	4.7	-1.2	-0.8	-1.5	0.7	1.1	1.0	0.7	-2.2	-0.1	1.7	-1.0
Intermittent access intake escalation	0.7	1.5	6.2	-1.1	-0.8	-1.4	0.7	1.1	1.0	0.7	-2.5	0.1	1.5	-0.8
Intermittent access intake escalation 2	0.8	0.9	3.9	-0.5	-0.5	-0.7	0.2	0.5	0.5	0.1	-2.0	-0.1	1.7	-1.2
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.7	0.5	0.2	0.4	-0.2	-0.2	-0.3	-0.3	1.3	-0.9	-0.9	0.8
Intermitt. access day 15 inactive lever presses	1.0	2.1	5.5	-1.6	-1.6	-1.8	1.0	1.6	1.5	1.3	-2.4	0.2	1.3	-0.5
Intermitt. access escalation Index	0.6	0.8	4.1	-0.5	-0.0	-1.3	0.3	0.2	0.1	-0.2	-1.0	-0.2	2.0	-1.3
Intermittent access day 1 total infusions	0.3	0.5	1.9	0.2	-0.0	0.5	0.4	0.3	0.3	0.2	1.4	0.5	-1.4	1.2
Intermittent access day 15 total infusions	0.9	1.3	3.7	-1.1	-1.0	-1.3	1.2	1.3	1.2	1.0	-1.9	0.7	0.6	-0.1
Intermittent access terminal intake (last 3 days)	0.7	0.9	4.5	-0.7	-0.6	-1.0	0.6	0.8	0.7	0.4	-2.1	0.4	1.2	-0.8
Intermittent access total infusions	0.3	0.4	0.7	-0.6	-0.7	-0.6	0.7	0.8	0.8	0.7	-0.8	0.6	0.0	0.1
Intermittent access day 1 locomotion	1.3	1.7	5.8	0.7	0.4	2.4	-1.3	-0.3	-0.4	0.1	1.7	-0.4	-2.4	0.9
Intermittent access day 15 total locomotion	0.3	0.6	1.3	-0.9	-1.1	-0.6	0.4	0.9	0.8	1.1	-0.8	0.1	-0.8	0.5
Intermittent access total locomotion	0.5	0.6	1.3	-0.7	-1.1	0.5	0.3	1.0	0.9	1.2	-0.2	0.9	-1.0	0.4
Intermittent access standard deviation	0.9	1.8	4.9	1.2	1.2	1.0	-2.0	-1.3	-1.3	-1.2	-0.4	-2.2	0.6	-1.3
Left kidney weight	0.2	0.9	2.7	-0.1	-0.8	0.0	0.1	0.6	0.6	1.3	0.9	0.7	-1.6	1.6
Right kidney weight	0.2	1.0	4.0	0.2	-0.6	-0.7	0.5	0.2	0.2	1.1	1.0	0.6	-1.8	2.0
Cocaine induced anxiety	1.4	2.1	3.6	-1.9	-1.8	-1.7	1.2	1.5	1.5	1.6	-1.8	1.0	0.7	-0.2
Post-drug Anxiety	2.2	2.3	7.2	-1.7	-1.7	-2.7	1.9	1.4	1.4	1.5	-1.0	1.2	0.3	0.7
Baseline Anxiety	0.5	0.6	1.9	0.5	0.3	-0.9	0.6	-0.3	-0.2	-0.0	1.1	0.1	-1.1	1.4
Tail length	1.9	7.2	12.3	-3.1	-3.4	-1.3	2.4	3.4	3.3	3.2	-2.2	3.5	-0.6	0.7
Length with tail	1.8	8.0	13.6	-3.3	-3.5	-2.0	2.7	3.5	3.4	3.2	-2.2	3.7	-0.5	1.0
Length without tail	0.5	1.6	4.6	-1.2	-1.5	-2.1	1.4	0.9	1.0	1.3	-0.6	1.5	-0.3	1.0
LgA early post infusion interval	0.3	0.4	1.0	-0.5	-0.5	-0.6	0.3	0.3	0.5	0.8	-0.5	-0.3	-1.0	0.8
LgA late post infusion interval	1.0	1.2	2.9	-0.1	0.4	-0.2	-1.2	-1.2	-1.0	-0.5	-1.6	-1.7	1.1	-1.5
LgA early loading	1.3	2.5	5.9	2.0	2.4	0.9	-1.3	-2.0	-2.0	-2.1	0.9	-1.2	0.2	-0.6
LgA late loading	0.1	0.2	0.8	0.6	0.3	-0.1	0.1	-0.3	-0.4	-0.3	0.9	-0.0	-0.2	0.2
LgA early average infusions	1.4	1.8	3.4	1.6	1.8	1.1	-1.3	-1.7	-1.7	-1.6	0.7	-0.8	0.3	-0.9
LgA late average infusions	0.2	0.3	1.7	0.5	0.1	0.6	0.3	0.4	0.2	-0.1	1.3	0.5	-0.2	0.5
LgA early timeout	0.8	0.9	2.2	0.7	1.2	1.1	-0.8	-0.6	-0.8	-1.2	0.0	-0.1	1.2	-1.5
LgA late timeout	0.2	0.3	1.4	-0.3	-0.6	0.5	0.1	0.7	0.7	0.4	1.2	0.5	-0.1	0.2
LgA early titration	0.5	0.7	1.7	1.0	1.3	0.3	-0.5	-1.1	-1.1	-1.1	0.4	-0.1	0.6	-0.8
LgA late titration	0.6	0.9	2.2	-0.3	-0.7	0.1	1.0	1.3	1.0	0.8	1.3	1.5	-0.5	0.9
LgA total infusion	0.6	0.8	2.2	1.2	0.9	0.8	-0.6	-0.8	-1.0	-1.1	1.5	-0.3	0.4	-0.4
Times rat made contact with spout	2.8	3.2	11.1	-0.2	1.3	0.1	-1.6	-1.6	-1.5	-2.0	-0.7	-1.4	2.9	-3.3
Lifetime Intake	0.3	0.3	1.1	-0.5	-0.6	-0.2	0.4	0.7	0.7	0.7	-1.0	0.6	-0.3	0.1
Liver weight, left	0.5	0.9	1.8	1.3	0.7	1.1	-1.1	-0.5	-0.6	-0.1	1.2	-0.7	-1.3	0.8
Liver weight, right	1.1	1.9	4.3	1.8	1.0	2.1	-1.7	-1.1	-1.2	-0.4	1.3	-1.0	-1.8	0.7
Locomotor activity	0.6	1.0	3.2	-0.9	-0.3	-0.7	0.1	0.3	0.1	-0.3	-1.6	0.7	1.8	-1.6
Locomotor testing distance	0.5	0.9	2.4	-0.9	-0.7	-0.6	1.3	1.2	1.1	0.5	-1.2	1.6	0.2	0.2
Locomotor testing rearing	1.1	2.2	4.9	-2.1	-1.5	-1.6	1.2	1.4	1.4	0.8	-2.2	1.1	1.5	-0.6
Locomotion in novel chamber	1.8	2.4	5.5	2.3	2.0	0.7	-0.3	-1.9	-2.0	-1.9	1.9	0.0	-0.8	0.7
Locomotion in novel chamber post-restriction	1.5	2.4	4.3	2.1	1.7	1.5	-1.3	-1.6	-1.5	-1.4	2.1	-1.8	-0.8	0.5
Fecal boli incidents, locomotor time 1	0.2	0.3	1.1	0.3	0.5	1.1	-1.0	-0.4	-0.4	-0.1	0.3	-0.6	-0.3	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	2.1	-0.6	-0.9	-0.4	-0.2	0.0	0.1	-0.2	-0.4	0.2	1.2	-1.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.5	0.0	-0.6	0.2	-0.7	-0.8	-0.5	0.8	-0.9	-0.0	0.5
Bouts of movement, locomotor time 1	0.9	1.0	4.9	-0.8	-0.5	-2.2	1.4	0.4	0.5	-0.3	-0.5	0.3	1.6	-0.4
Total resting periods, locomotor time 1	0.4	0.5	2.6	-0.4	-0.0	-1.6	0.7	0.1	0.0	-0.4	-0.4	-0.3	1.2	-0.5
Rest time, locomotor task time 1	0.1	0.2	1.1	0.1	0.4	0.0	-0.4	-0.2	0.0	-0.2	0.5	-1.0	0.1	-0.2
Distance moved, locomotor task time 1	0.2	0.3	0.9	-0.6	-0.8	0.3	0.1	0.4	0.5	0.9	-0.7	0.7	-0.5	0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.7	-0.3	-0.5	0.1	0.1	0.3	0.1	0.3	-0.6	0.8	-0.0	-0.2
Time >=10cm from walls, locomotor time 2	0.8	1.2	6.1	1.0	0.1	1.1	-0.2	-0.2	-0.2	-0.2	2.5	-1.1	-1.3	1.2
Bouts of movement, locomotor time 2	1.7	2.6	4.5	-0.6	-1.4	0.2	1.6	2.1	1.8	1.7	1.6	1.7	-1.9	2.0
Total resting periods, locomotor time 2	1.4	2.4	4.4	-0.7	-1.6	-0.1	1.7	2.1	1.9	1.5	1.3	1.7	-1.5	1.7
Rest time, locomotor task time 2	0.3	0.4	0.9	-0.0	0.3	-0.3	-0.6	-0.7	-0.8	-0.6	-0.3	-0.9	0.9	-0.9
Distance moved, locomotor task time 2	0.1	0.1	0.6	0.5	0.1	0.6	-0.2	-0.2	-0.0	-0.1	0.8	-0.1	-0.4	0.3
Vertical activity count, locomotor time 2	0.2	0.3	1.1	0.9	0.5	0.6	0.1	-0.3	-0.4	-0.2	1.0	0.3	-0.7	0.6
Light reinforcement 1	0.2	0.4	0.9	-0.4	-0.7	-0.2	0.8	1.0	0.9	0.6	0.7	0.7	-0.5	0.5
Light reinforcement 2	1.1	1.7	5.1	0.4	-0.5	0.6	1.1	1.4	1.3	1.3	0.5	1.2	-2.3	2.2
Bone: marrow area	0.0	0.1	0.2	0.1	-0.2	-0.3	-0.0	0.4	0.3	-0.0	0.0	0.5	0.1	0.2
Bone: maximum diameter	2.1	4.0	7.1	-2.6	-2.7	-2.2	1.7	2.1	1.9	2.0	-1.9	2.5	0.5	0.2
Bone: maximum force	0.1	0.2	0.5	-0.7	-0.6	-0.6	0.2	0.5	0.4	0.5	-0.1	0.6	0.1	0.2
Bone: maximum moment	0.2	0.3	0.7	-0.8	-0.8	-0.7	0.4	0.6	0.6	0.7	-0.1	0.8	0.0	0.3
Mean time between licks in bursts	0.2	0.4	1.3	-0.8	-0.6	0.2	0.1	0.5	0.4	-0.0	0.2	0.8	1.1	-1.1
Mean num. licks in bursts	3.4	5.3	9.0	1.3	2.2	1.8	-3.0	-2.9	-2.7	-2.4	0.9	-2.6	1.6	-2.8
Cd content in liver	0.6	0.6	2.2	-1.3	-0.7	-0.9	0.2	0.4	0.3	0.2	-1.5	0.3	0.9	-0.7
Co content in liver	1.1	1.3	2.8	-1.3	-1.2	-1.6	1.1	1.0	1.0	0.7	-1.7	1.3	0.4	0.1
Cu content in liver	0.2	0.2	0.7	-0.8	-0.3	-0.3	-0.5	0.0	-0.1	-0.1	-0.0	-0.1	0.8	-0.8
Fe content in liver	0.9	1.1	2.9	1.6	1.2	1.7	-0.9	-0.8	-0.8	-0.9	1.1	-0.4	-0.7	0.1
K content in liver	2.3	2.2	4.7	-0.8	-1.8	-0.8	1.5	1.7	1.5	2.2	0.8	1.0	-1.5	1.9
Mg content in liver	0.5	0.5	1.8	-0.5	-0.9	-1.4	0.8	0.5	0.2	0.8	0.3	0.2	-0.3	1.0
Mn content in liver	0.4	0.5	1.0	-0.3	-0.8	0.5	0.1	0.9	0.8	1.0	-0.6	0.4	-0.8	0.7
Na content in liver	2.0	2.2	4.9	-1.5	-1.7	-1.8	2.2	1.7	1.7	1.6	-0.3	1.4	0.1	0.9
Rb content in liver	0.6	0.7	2.1	-1.3	-1.4	-1.2	0.3	0.5	0.5	1.1	-0.4	0.2	0.2	0.2
Se content in liver	1.2	1.4	3.0	-1.1	-1.5	-0.6	1.4	1.3	1.4	1.7	-0.4	1.3	-0.8	0.9
Sr content in liver	3.7	3.2	6.3	-2.0	-1.9	-2.4	2.2	1.7	1.7	1.8	-1.0	2.5	0.2	0.9
Zn content in liver	0.8	0.8	2.6	-0.5	-1.2	-0.0	0.0	0.8	0.6	1.6	0.6	0.5	-1.4	1.2
Bone: minimum diameter	0.1	0.1	0.4	0.3	-0.3	0.2	-0.6	-0.3	-0.3	0.2	0.3	-0.1	-0.6	0.4
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.2	-0.0	-0.0	0.1	0.3	0.3	-0.1	-0.3	-0.2	-0.1	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.5	-0.4	-0.0	-0.1	-0.2	-0.4	-0.4	0.1	-0.3	0.3	0.5	-0.7
Total zone transitions, hab. session 1	0.1	0.2	1.4	-0.0	-0.1	1.2	-0.6	0.2	0.0	0.2	0.5	0.2	-0.2	-0.2
Total locomotion distance, hab. session 1	0.6	0.9	2.0	-0.0	-0.8	0.8	0.6	1.2	1.0	1.0	0.2	1.4	-1.1	1.1
Locomotion velocity, hab. session 1	0.3	0.5	1.2	0.2	-0.4	0.8	0.3	0.8	0.7	0.6	0.4	1.1	-0.9	0.8
Time in familiar zone, hab. session 2	1.0	1.1	2.3	1.2	1.1	0.5	-1.1	-1.3	-1.4	-1.0	0.9	-1.5	-0.1	-0.1
Time in novel zone, hab. session 2	1.1	1.1	2.6	-1.6	-1.0	-0.4	0.7	1.1	1.1	0.8	-1.3	1.3	0.9	-0.8
Total zone transitions, hab. session 2	0.9	1.1	2.7	-0.9	-1.2	0.8	0.4	1.4	1.3	1.6	0.3	1.2	-1.0	0.7
Total locomotion distance, hab. session 2	1.0	1.3	2.9	-1.1	-1.4	0.1	0.8	1.6	1.4	1.7	-0.0	1.2	-0.9	0.9
Locomotion velocity, hab. session 2	1.5	2.1	4.3	-1.2	-1.7	-0.0	1.1	1.9	1.8	2.1	0.0	1.5	-1.3	1.4
Novel to familiar place preference ratio	0.1	0.2	0.7	-0.5	-0.2	0.2	-0.1	0.3	0.3	-0.2	0.2	-0.2	0.8	-0.6
Novelty place preference	0.2	0.2	0.8	-0.5	-0.2	0.3	-0.3	0.1	0.1	-0.3	0.1	-0.3	0.9	-0.8
Time in novel zone, NPP test	0.2	0.3	1.1	-0.5	-0.1	0.2	-0.4	-0.0	-0.1	-0.4	-0.0	-0.2	1.1	-1.0
Total zone transitions, NPP test	0.5	0.8	2.8	0.7	0.0	1.1	-0.2	0.1	0.1	0.7	1.2	0.4	-1.7	1.3
Total locomotion distance, NPP test	0.8	1.1	3.6	0.4	-0.5	0.5	0.7	0.8	0.8	1.2	0.8	0.7	-1.9	1.8
Locomotion velocity, NPP test	1.0	1.4	4.0	0.2	-0.7	0.4	0.9	1.1	1.0	1.4	0.8	0.8	-2.0	2.0
Intraocular pressure	0.4	0.6	2.0	-0.9	-0.8	-0.4	0.7	0.8	0.6	0.3	-1.4	0.8	0.5	-0.4
Delta distance traveled before/after self-admin	0.7	0.7	3.6	0.8	0.7	0.5	-0.2	-0.4	-0.3	-0.3	1.9	-0.2	-1.3	1.0
Delta ambulatory time before/after self-admin	0.5	0.7	2.9	0.8	0.9	0.6	-0.2	-0.5	-0.4	-0.3	1.7	0.1	-1.2	0.8
Parametrial fat weight	0.7	1.7	5.2	-2.3	-1.7	-1.8	0.2	1.1	1.1	1.6	-1.2	-0.2	0.9	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.5	-0.2	-0.9	0.3	-0.1	-0.1	-0.3	-0.8	0.0	0.9	-0.6
Pavlov. Cond. magazine entry latency	0.9	1.2	2.2	1.5	1.4	1.4	-1.2	-1.0	-1.0	-1.2	0.8	-1.0	-0.2	-0.3
Pavlov. Cond. change in total contacts	1.0	1.1	2.2	-1.5	-1.3	-0.1	0.6	1.3	1.3	1.2	-0.9	1.4	0.1	-0.2
Pavlov. Cond. index score	0.6	0.8	1.9	1.3	1.0	1.4	-0.9	-0.7	-0.6	-0.6	1.0	-0.7	-0.8	0.3
Pavlov. Cond. latency score	0.6	0.8	2.0	1.2	0.9	1.4	-0.9	-0.6	-0.6	-0.4	1.1	-0.6	-0.9	0.4
Pavlov. Cond. lever contacts	0.3	0.4	1.3	0.7	0.4	1.1	-0.5	-0.1	-0.1	0.1	0.7	-0.3	-0.9	0.5
Pavlov. Cond. magazine entry number	0.9	1.2	1.9	-1.2	-1.3	-1.4	1.4	1.1	1.1	1.2	-0.5	1.1	-0.1	0.8
Pavlov. Cond. intertrial magazine entries	1.9	2.3	4.9	-0.2	-0.8	-0.0	1.5	2.1	2.1	1.7	0.4	1.6	-2.0	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.5	1.4	1.1	1.6	-1.1	-0.8	-0.7	-0.6	1.1	-0.8	-0.9	0.3
Pavlov. Cond. response bias	0.2	0.3	1.0	0.7	0.4	1.0	-0.6	-0.2	-0.2	-0.2	0.5	-0.3	-0.6	0.1
Pavlov. Cond. lever latency	2.8	3.8	7.1	-1.9	-2.6	-1.6	2.2	2.0	2.0	2.7	-0.5	1.8	-1.3	2.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	0.3	-0.2	0.1	0.1	0.1	-0.5	0.4	-0.2	0.2	-0.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	0.6	0.8	0.6	-0.8	-0.4	-0.4	-0.7	0.1	-0.1	0.3	-0.6
Pavlov. Cond. index score	0.8	1.1	2.2	1.2	1.5	0.8	-1.2	-0.9	-0.9	-1.5	0.5	-0.8	0.6	-1.0
Pavlov. Cond. latency score	0.8	1.0	2.3	1.3	1.5	0.8	-1.2	-0.9	-0.9	-1.4	0.6	-0.8	0.4	-0.8
Pavlov. Cond. lever contacts	2.9	4.0	7.4	2.1	2.6	1.7	-2.2	-2.0	-2.0	-2.7	0.6	-1.9	1.2	-1.9
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	-0.2	-0.7	0.1	0.8	0.7	0.7	1.1	0.1	0.9	-1.3	1.4
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.3	-0.3	-0.6	-0.0	0.1	0.2	0.1	0.5	0.0	0.1	0.0	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.6	1.3	1.6	0.8	-1.3	-1.1	-1.1	-1.6	0.5	-0.8	0.7	-1.0
Pavlov. Cond. response bias	1.9	2.5	5.0	1.4	2.0	1.2	-1.8	-1.5	-1.5	-2.2	0.4	-1.4	1.4	-1.9
LgA PC1 addiction-like behavior	0.2	0.3	1.5	0.6	0.7	0.5	-0.0	-0.3	-0.4	-0.4	1.2	0.5	-0.2	0.1
Time in closed arm before self-admin	0.2	0.3	1.3	-0.5	-0.4	0.2	0.3	0.6	0.6	0.5	0.7	1.2	-0.1	-0.2
Time in closed arm after self-admin	1.9	2.0	8.4	1.5	1.4	1.6	-1.1	-1.0	-1.0	-1.0	2.9	-1.0	-1.3	0.5
Time in open arm before self-admin	0.7	0.7	2.0	1.1	1.4	0.7	-0.2	-0.6	-0.6	-1.0	1.0	-0.6	-0.6	0.7
Time in open arm after self-admin	0.5	0.6	3.3	-0.8	-0.7	-0.3	-0.0	0.4	0.6	0.4	-1.8	-0.3	0.9	-0.6
Bone: periosteal estimation	0.4	0.9	2.2	-0.9	-1.2	-1.0	0.7	1.1	1.0	1.0	-0.6	1.5	-0.3	0.7
Bone: periosteal perimeter	1.5	2.5	4.2	-1.2	-2.1	-1.5	1.7	1.8	1.7	1.8	-0.4	2.0	-1.0	1.5
Bone: post-yield work	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.6	0.2	0.3	0.1	0.7	0.3	0.0	0.6
Progressive ratio test 1 active lever presses	0.3	0.4	0.9	-0.4	-0.7	0.3	0.3	0.8	0.8	0.8	0.6	0.2	-1.0	0.7
Progressive ratio test 1 breakpoint	0.4	0.5	1.0	-0.5	-0.8	0.3	0.4	0.8	0.8	0.8	0.6	0.3	-1.0	0.7
Progressive ratio test 1 inactive lever presses	2.3	3.3	6.7	-2.1	-2.3	-0.9	1.3	2.3	2.3	2.6	-0.8	0.9	-1.6	1.5
Progressive ratio test 2 active lever presses	0.5	0.5	1.2	-0.6	-0.7	-0.9	1.1	0.8	0.7	0.5	-0.8	1.0	0.3	0.1
Progressive ratio test 2 breakpoint	0.5	0.5	1.2	-0.5	-0.6	-1.0	1.1	0.7	0.7	0.5	-0.8	1.0	0.4	-0.0
Progressive ratio test 2 inactive lever presses	0.7	1.1	1.9	-1.1	-1.3	-1.1	0.9	1.3	1.2	1.4	-0.2	0.0	-0.9	1.1
ShA PR total presses	2.8	3.2	7.4	2.7	2.5	0.9	-1.1	-2.5	-2.4	-2.1	1.4	-1.1	-0.5	0.2
Incentive Sensitization - Responses	0.7	1.0	3.3	-0.6	-0.3	-1.8	1.4	0.6	0.5	0.4	-1.5	1.4	0.6	0.1
Incentive Sensitization - Breakpoint	0.8	1.0	3.7	-0.5	-0.2	-1.9	1.4	0.5	0.4	0.2	-1.6	1.3	0.8	-0.0
LgA PR total presses	1.2	1.3	2.4	1.2	0.8	0.5	-1.2	-1.5	-1.5	-1.3	1.3	-0.9	0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.7	0.6	1.2	-0.6	-0.6	-0.7	1.1	0.5	0.6	0.8	-0.7	1.1	-0.8	0.9
Progressive ratio	0.3	0.5	1.7	0.6	-0.1	1.0	-0.7	-0.5	-0.5	0.2	0.8	-0.8	-1.3	0.7
Food seeking constrained by brief footshock	2.7	3.4	6.6	-1.4	-2.2	-1.3	1.8	1.8	1.9	2.4	0.5	1.0	-2.1	2.6
Seeking ratio, punishment vs. effort	1.2	1.8	3.6	-1.4	-1.2	-1.0	1.6	1.9	1.9	1.4	-0.1	1.6	-0.4	1.0
Retroperitoneal fat weight	0.3	1.5	3.6	-1.8	-1.6	-1.9	0.7	1.3	1.1	1.3	-1.2	0.4	0.4	0.2
Reaction time number correct	0.1	0.2	1.2	-0.4	-0.1	-0.1	-0.1	-0.2	-0.2	-0.5	-0.2	-0.3	1.1	-0.9
Reaction time mean minus median	1.1	2.7	4.7	1.5	1.7	0.2	-1.6	-1.9	-2.0	-2.2	1.7	-1.9	1.3	-1.2
Reaction time mean minus median AUC	0.8	2.1	4.3	1.3	1.6	0.0	-1.1	-1.5	-1.5	-2.1	1.8	-1.7	1.3	-0.9
Reaction time num false alarms	1.1	1.5	3.9	-1.0	-1.2	-1.3	2.0	1.3	1.2	1.2	-0.7	1.5	-0.5	0.9
Reaction time num false alarms AUC	1.2	1.9	5.2	-0.8	-1.2	-1.5	2.3	1.2	1.2	1.4	-0.5	1.8	-0.9	1.5
Reaction time trials correct on left	0.1	0.2	1.2	-0.4	-0.1	-0.1	-0.1	-0.2	-0.2	-0.5	-0.2	-0.3	1.1	-0.9
Reaction time trials on left	0.1	0.2	1.2	-0.3	-0.1	-0.1	-0.1	-0.2	-0.2	-0.5	-0.1	-0.3	1.1	-0.9
Reaction time mean	0.6	0.9	2.1	1.3	1.1	0.1	-0.4	-1.3	-1.4	-0.8	0.9	-1.3	-0.1	0.2
Reaction time mean AUC	0.8	1.3	2.5	1.6	1.3	0.2	-0.5	-1.4	-1.6	-1.0	1.2	-1.5	-0.3	0.4
Median of all reaction times	0.4	0.6	1.3	1.1	0.8	0.3	-0.2	-1.0	-1.1	-0.3	0.5	-1.1	-0.6	0.6
Reaction time omissions	0.6	0.9	2.0	1.0	1.2	0.3	-0.5	-1.3	-1.4	-1.1	0.7	-1.1	0.4	-0.2
Reaction time false alarm rate	1.5	2.0	4.8	-0.6	-1.1	-1.3	2.2	1.3	1.3	1.6	-0.3	1.8	-1.3	1.8
Reaction time premature initiation rate	1.7	2.4	5.2	2.1	1.8	2.3	-2.2	-1.1	-1.2	-1.1	1.1	-1.3	-1.2	0.1
Reaction time premature initiations	0.8	1.5	3.8	1.5	1.4	1.8	-1.9	-1.0	-1.0	-1.2	0.6	-1.1	-0.3	-0.5
Std. dev. reaction times	1.0	1.8	3.4	1.4	1.4	-0.2	-0.9	-1.7	-1.8	-1.7	1.4	-1.8	0.8	-0.5
Reaction time trials completed	0.1	0.2	1.2	-0.3	-0.1	-0.1	-0.1	-0.2	-0.2	-0.5	-0.1	-0.3	1.1	-0.9
Reaction time trials AUC	0.1	0.2	1.0	-0.4	-0.2	-0.1	0.0	-0.1	-0.1	-0.3	-0.2	-0.2	1.0	-0.7
Run reversals in cocaine runway, females	0.9	0.9	4.3	0.7	0.2	-0.8	0.8	0.1	0.1	-0.3	2.1	-0.3	-0.7	1.7
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.5	-0.3	-0.2	-0.1	0.3	0.3	0.3	0.2	0.0	0.2	-0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-0.7	-0.6	-0.9	1.2	0.7	0.7	0.9	-0.6	0.7	-0.4	1.0
Latency to leave start box in cocaine runway, F	1.8	2.0	5.3	-1.2	-1.5	-1.7	2.3	1.3	1.3	1.3	-0.6	1.8	-0.4	1.4
Latency to leave start box in cocaine runway, M	0.5	0.5	1.7	0.3	1.0	0.9	-1.1	-0.5	-0.5	-0.2	-0.4	-1.3	-0.2	-0.1
Std. dev. time between licks in bursts	0.2	0.2	0.5	-0.2	-0.2	0.3	0.3	0.7	0.7	-0.3	0.6	0.6	0.6	-0.5
Total sessions with >9 infusions	1.2	1.4	3.7	1.3	1.4	1.9	-1.6	-1.1	-1.1	-1.0	0.9	-1.0	-0.7	-0.3
Short access day 1 total inactive lever presses	1.3	1.8	3.7	-1.8	-1.9	-0.6	0.7	1.8	1.6	1.8	-1.4	0.5	-0.2	0.3
Short access day 10 total inactive lever presses	0.1	0.3	1.5	-0.4	-0.6	0.0	-0.4	0.4	0.4	0.5	0.2	-1.2	-0.5	0.4
Short access day 1 total infusions	1.1	1.5	3.9	1.0	0.9	2.0	-1.8	-0.9	-1.0	-0.6	1.3	-1.5	-1.2	0.1
Short access day 10 total infusions	0.3	0.4	1.0	0.9	0.9	1.0	-0.4	-0.5	-0.5	-0.6	0.7	0.2	-0.8	0.2
Short access total infusions	0.2	0.2	1.0	0.3	0.3	1.0	-0.7	-0.2	-0.2	-0.1	-0.2	0.0	-0.5	-0.3
ShA early post infusion interval	1.4	1.3	4.4	-1.1	-0.6	0.5	0.9	1.4	1.5	0.9	-1.4	2.1	0.2	-0.4
ShA late post infusion interval	0.4	0.4	1.2	-0.2	-0.6	0.2	0.1	0.5	0.5	0.7	1.0	-0.3	-1.1	1.0
ShA early loading	0.6	0.6	1.1	0.9	0.7	0.8	-0.8	-0.9	-0.9	-0.9	0.7	-1.0	0.2	-0.3
ShA late loading	2.8	3.8	6.5	2.2	2.1	1.1	-2.0	-2.5	-2.5	-2.4	0.9	-2.1	1.0	-1.5
Short access day 1 locomotion	1.6	2.0	6.4	1.1	1.1	2.5	-1.5	-0.8	-0.8	-0.5	2.0	-0.4	-2.2	0.7
Short access day 10 total locomotion	2.0	3.7	10.7	1.5	0.7	3.3	-2.3	-1.0	-1.0	-0.5	3.3	-1.1	-2.7	0.7
Short access total locomotion	2.4	2.9	10.3	1.5	1.2	3.2	-2.3	-1.2	-1.2	-1.0	2.1	-1.1	-1.6	-0.2
ShA early average infusions	0.3	0.4	1.3	0.7	0.3	0.2	-0.7	-1.1	-1.0	-0.6	0.0	-0.7	0.1	-0.4
ShA late average infusions	2.1	2.2	4.5	2.1	2.0	1.0	-1.1	-1.9	-1.9	-1.4	1.4	-1.0	-0.9	0.2
ShA early timeout	0.3	0.3	0.8	0.0	-0.1	-0.2	-0.6	-0.8	-0.6	-0.3	-0.4	-0.9	0.8	-0.7
ShA late timeout	0.8	0.9	2.1	1.5	1.3	0.7	-0.5	-1.2	-1.1	-1.2	0.7	-0.4	-0.4	0.1
ShA early titration	0.3	0.3	0.7	0.7	0.3	0.3	-0.6	-0.8	-0.8	-0.6	0.6	-0.5	0.3	-0.4
ShA late titration	2.4	2.5	4.7	2.1	1.9	1.2	-1.4	-2.2	-2.2	-1.6	1.4	-1.4	-0.5	-0.3
ShA total infusions	2.3	2.8	5.6	2.4	2.0	0.9	-1.3	-2.3	-2.2	-1.7	1.8	-1.6	-0.7	0.2
One hour access (0.3 mA shock)	0.4	0.4	1.0	-0.6	-1.0	-0.2	0.6	0.8	0.7	1.0	-0.1	0.6	-0.6	0.4
Shock compulsivity	0.4	0.7	2.2	1.1	0.6	0.1	0.4	-0.4	-0.4	-0.2	1.4	0.3	-1.2	1.5
Compulsive drug intake	0.8	0.9	2.1	1.2	1.4	1.1	-0.5	-1.3	-1.2	-1.3	0.5	-0.1	-0.1	-0.1
One hour access (shock baseline)	0.3	0.4	1.2	-0.7	-1.1	-0.7	0.4	0.8	0.7	1.0	-0.1	0.2	-0.3	0.2
Social response proportion	0.5	0.6	1.7	-1.1	-1.1	-0.1	0.3	0.8	0.9	1.3	-0.2	0.7	-0.4	0.1
Social responses	1.0	1.3	3.3	-1.8	-1.7	-1.0	0.8	1.2	1.2	1.3	-0.5	0.9	0.6	-0.7
Social time	0.1	0.2	0.6	-0.8	-0.5	-0.6	0.1	-0.1	-0.1	0.5	0.4	-0.4	0.3	-0.3
Soleus weight	0.9	2.7	4.6	-1.0	-2.0	-1.0	1.8	1.7	1.6	2.2	-0.4	2.1	-1.6	1.8
Bone: stiffness	0.1	0.1	0.4	0.2	0.2	0.1	-0.7	-0.1	-0.2	-0.4	0.3	-0.4	0.2	-0.2
Tibialis anterior weight	0.8	2.7	4.7	-2.1	-1.7	-2.2	1.6	1.4	1.6	1.3	-2.0	2.0	0.5	0.0
Time to tail flick, vehicle, before self-admin	0.7	0.7	3.8	0.0	-0.3	0.5	-0.2	0.2	0.2	0.9	1.0	-0.4	-2.0	1.3
Time to tail flick, vehicle, after self-admin	0.5	0.7	3.9	0.1	-0.7	-0.3	0.4	0.2	-0.0	0.5	2.0	-0.3	-1.0	1.1
Time to tail flick, test, before self-admin	0.5	0.5	1.7	0.4	0.7	0.3	-0.5	-0.6	-0.4	-0.8	-0.7	-0.1	1.2	-1.3
Time to tail flick, test, after self-admin	2.0	2.1	4.2	-1.7	-1.7	0.3	1.1	2.1	1.9	1.9	-0.5	1.6	-1.0	0.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	2.4	0.4	0.0	-0.4	0.4	-0.2	-0.3	-0.3	1.6	0.1	-0.2	0.5
Delta time to tail flick, test, before/after SA	1.3	1.3	2.6	-1.4	-1.6	-0.1	0.8	1.6	1.3	1.6	-0.1	0.7	-0.9	0.9
Tibia length	0.3	0.8	3.2	0.7	-0.3	0.2	0.7	0.7	0.6	0.7	0.6	0.9	-1.6	1.8
Ambulatory time before self-admin	0.3	0.4	1.0	-0.6	-1.0	-0.8	0.7	0.6	0.6	0.4	-0.9	0.1	0.5	0.4
Ambulatory time after self-admin	0.2	0.2	0.9	0.1	-0.1	0.5	0.0	0.1	0.2	0.3	0.6	0.1	-0.9	1.0
Bone: tissue strength	1.0	1.0	2.8	-0.2	0.5	0.1	-1.0	-0.8	-0.9	-1.1	-0.9	-0.7	1.6	-1.7
Total heroin consumption	0.1	0.2	0.3	0.3	0.3	0.6	-0.6	-0.5	-0.4	-0.0	-0.4	0.1	-0.3	-0.2
Total infusions	0.8	1.0	2.2	1.3	1.1	0.7	-0.7	-1.1	-1.2	-1.2	1.5	-0.5	0.4	-0.4
Bone: trabecular number	0.0	0.0	0.0	0.2	0.2	0.1	-0.2	-0.2	-0.1	-0.2	-0.1	0.1	0.1	-0.1
Bone: trabecular spacing	0.7	0.9	2.6	-0.9	-1.1	-1.3	1.6	0.9	1.1	0.9	-0.1	0.7	0.1	0.6
Bone: trabecular thickness	0.4	0.5	1.2	1.1	0.8	0.7	-0.4	-0.0	-0.2	-0.2	0.9	0.1	-1.1	0.9
Bone: trabecular tissue density	0.6	0.9	1.4	0.6	1.0	0.2	-1.2	-1.0	-0.9	-1.2	1.1	-1.2	0.8	-0.7
Water consumed over 24 hours	0.6	0.9	2.7	-1.2	-0.4	-0.5	0.1	0.4	0.5	-0.1	-1.4	0.3	1.6	-1.6
Number of responses in last shaping day	0.3	0.3	1.0	0.0	0.1	0.9	-0.5	0.1	-0.0	0.1	0.9	-0.5	-1.0	0.7