Hub : Genes

H2az2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression H2az2 0.18 0.12 9.7e-03 0.01 0.01 0.03 0.01 1.6e-01 1.4e-01 5.7e-02 1.6e-01
2 Liver mRNA stability H2az2 0.07 0.05 9.2e-04 0.03 0.01 0.01 0.02 6.8e-04 1.3e-02 1.6e-02 5.5e-03
3 Liver isoform ratio XM_039092453.2 0.07 0.04 2.1e-05 0.04 0.04 0.03 0.03 2.8e-05 3.3e-05 1.4e-04 3.2e-04
4 PL mRNA stability H2az2 0.03 0.02 1.4e-03 0.03 0.02 0 0.02 3.0e-04 2.5e-03 9.5e-02 1.3e-03
5 NAcc mRNA stability H2az2 0.06 0.04 2.5e-06 0.04 0.04 0.04 0.04 2.3e-07 4.8e-06 9.8e-07 1.1e-06
6 pVTA mRNA stability H2az2 0.13 0.09 7.5e-05 0.04 0.04 0.04 0.05 2.2e-04 3.0e-04 6.6e-04 5.4e-05
7 Brain gene expression H2az2 0.05 0.03 7.3e-03 0.01 0.02 0.03 0.02 2.9e-02 2.5e-03 4.7e-04 9.2e-03
8 Liver isoform ratio XM_017599381.3 0.02 0.01 9.1e-03 0.01 0.01 0.01 0.01 1.3e-02 1.4e-02 7.1e-02 1.7e-02
9 Brain mRNA stability H2az2 0.31 0.22 4.2e-12 0.15 0.11 0.12 0.14 1.1e-13 1.8e-10 4.3e-11 5.8e-13
10 RMTg intron excision ratio chr14_85509589_85514289 0.32 0.15 1.9e-03 0.11 0.05 0.08 0.11 9.3e-04 2.0e-02 4.3e-03 6.4e-04
11 RMTg intron excision ratio chr14_85514402_85520891 0.3 0.23 5.0e-03 -0.01 0.01 -0.01 0.01 9.9e-01 1.3e-01 9.4e-01 1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.00.10.20.30.4-0.2-0.1-0.2-0.00.3-0.0-0.0-0.0
Area under the delay curve4.04.610.8-1.9-1.6-2.03.32.52.20.62.12.5-1.32.4
BMI with tail0.20.63.0-1.7-0.9-0.90.90.20.70.1-0.20.2-0.20.7
BMI without tail0.31.01.9-1.1-1.2-1.30.91.21.4-0.40.51.0-0.50.7
Body weight1.46.09.1-3.0-2.7-3.02.72.72.8-1.22.52.6-0.81.7
Weight adjusted by age0.20.40.8-0.7-0.5-0.40.80.70.50.30.60.6-0.30.9
Bone surface0.10.20.4-0.4-0.4-0.20.10.4-0.0-0.60.60.30.6-0.4
Bone volume0.10.20.6-0.6-0.5-0.30.30.50.1-0.70.80.40.5-0.2
Breakpoint value in progressive ratio session0.20.31.3-0.4-0.5-0.20.60.30.4-0.71.10.4-0.00.1
Number of licking bursts2.03.36.1-2.2-1.7-1.72.52.21.4-1.52.12.10.30.9
Context. condit. distance diff. score1.72.14.11.11.81.8-1.2-1.7-2.01.0-1.3-1.70.6-0.9
Locomotion velocity, session 10.60.62.21.50.20.7-1.2-0.5-0.70.1-0.7-0.60.6-1.1
Locomotion distance, session 10.91.23.61.90.90.3-0.30.30.61.40.70.2-1.91.4
Locomotion velocity, session 21.31.55.11.5-0.20.6-1.5-0.8-1.1-0.8-0.6-0.81.7-2.3
Locomotion distance, session 20.91.24.42.11.11.0-1.7-0.8-0.40.8-0.9-0.9-0.7-0.1
Locomotion velocity, session 30.91.13.01.71.41.0-1.0-1.0-1.10.9-0.7-1.0-0.3-0.1
Locomotion distance, session 30.30.31.2-0.3-0.8-1.10.70.60.5-0.50.50.60.2-0.1
Stereotopy head waving bouts, day 30.60.73.61.90.70.7-1.2-0.5-0.30.2-0.2-0.6-0.3-0.5
Stereotopy head waving duration, day 32.02.35.52.41.61.9-2.1-1.6-1.40.7-1.2-1.6-0.0-1.0
Locomotion velocity, session 70.20.20.70.2-0.5-0.40.10.40.2-0.80.40.40.2-0.4
Locomotion distance, session 70.10.10.20.00.30.4-0.0-0.1-0.4-0.1-0.0-0.20.3-0.4
Stereotopy head waving bouts, day 70.10.10.40.20.30.30.1-0.3-0.60.3-0.2-0.20.5-0.1
Stereotopy head waving duration, day 70.10.10.30.50.30.2-0.1-0.1-0.20.4-0.00.0-0.10.3
Locomotion velocity, session 81.31.52.81.71.01.2-1.5-1.0-1.70.5-0.6-1.01.1-1.6
Locomotion distance, session 84.46.49.73.13.02.9-3.0-2.7-2.62.0-2.5-2.80.1-1.2
Degree of sensitization distance1.92.04.91.01.72.2-1.4-1.4-1.90.8-1.2-1.50.5-0.9
Degree of sensitization stereotypy0.10.10.2-0.3-0.1-0.10.40.1-0.20.20.10.20.30.3
Conditioned locomotion0.70.83.61.11.00.2-0.20.30.41.00.50.4-1.91.4
Cocaine response after cond. corrected1.21.43.4-0.9-1.2-1.31.51.51.0-0.81.81.60.30.4
Cocaine response after cond. not corrected1.72.04.3-1.2-1.3-1.41.91.61.2-1.02.11.7-0.00.8
Cocaine response before conditioning0.10.20.40.00.70.40.1-0.3-0.20.3-0.3-0.3-0.60.7
Saline control response0.20.30.70.60.30.4-0.8-0.5-0.70.0-0.4-0.50.5-0.7
Bone: connectivity density0.10.20.50.40.50.7-0.4-0.6-0.5-0.0-0.2-0.70.2-0.4
Bone: cortical apparent density0.20.30.8-0.7-0.9-0.80.80.50.6-0.40.10.50.30.1
Bone: cortical area1.62.54.4-1.6-1.7-2.01.61.71.9-1.02.11.6-0.61.1
Bone: cortical porosity0.00.00.20.4-0.10.4-0.4-0.00.00.00.00.1-0.0-0.3
Bone: cortical porosity0.10.10.40.30.40.6-0.2-0.1-0.10.5-0.0-0.0-0.40.3
Bone: cortical thickness1.32.13.9-1.3-1.4-1.61.61.51.8-0.72.01.5-0.91.2
Bone: cortical thickness0.50.61.9-0.10.90.70.80.3-0.11.00.70.4-1.21.4
Bone: cortical tissue density0.30.40.9-0.8-1.0-0.80.90.50.6-0.50.10.50.40.0
Condit. Reinf. active minus inactive responses0.80.93.1-0.7-1.5-0.90.60.80.5-1.80.40.81.1-0.8
Condit. Reinf. active-inactive response ratio1.21.34.1-0.5-0.50.5-0.5-0.9-1.1-1.3-0.8-0.92.0-1.9
Condit. Reinf. active responses0.50.62.0-0.2-1.1-0.70.51.00.6-1.40.51.00.4-0.3
Condit. Reinf. inactive responses0.81.02.3-0.1-0.5-0.90.91.51.1-0.31.21.5-0.91.1
Incentive salience index mean1.41.73.0-0.9-1.7-1.51.21.61.3-1.71.21.60.30.1
Condit. Reinf. lever presses1.31.83.4-0.0-0.8-1.41.01.81.8-0.51.41.8-1.31.6
Condit. Reinf. active minus inactive responses0.10.20.40.60.60.6-0.7-0.2-0.50.4-0.2-0.2-0.2-0.0
Condit. Reinf. active-inactive response ratio0.20.20.5-0.1-0.2-0.30.30.70.40.30.60.6-0.40.5
Condit. Reinf. active responses0.40.61.51.10.90.8-1.2-0.6-0.60.4-0.7-0.7-0.2-0.3
Condit. Reinf. inactive responses1.11.42.71.21.11.3-1.6-1.4-1.30.1-1.3-1.40.4-1.0
Condit. Reinf. lever presses0.10.20.50.60.70.6-0.3-0.1-0.50.40.1-0.1-0.10.0
Condit. Reinf. lever reinforcers received0.20.30.90.90.70.7-1.0-0.3-0.50.2-0.2-0.4-0.2-0.3
Conditioned reinforcement - actives0.10.10.7-0.2-0.3-0.0-0.10.20.2-0.9-0.30.1-0.2-0.1
Conditioned reinforcement - inactives0.20.30.9-0.7-0.6-0.40.60.70.5-1.00.00.7-0.00.3
Conditioned locomotion0.60.82.2-0.3-1.2-1.00.21.11.2-1.50.21.0-0.50.0
Patch foraging indifference point 0 sec2.03.67.7-2.8-2.1-1.51.81.30.6-2.52.71.32.0-1.1
Patch foraging indifference point AUC0.20.31.30.2-0.40.0-0.30.3-0.2-1.10.10.40.7-0.9
Delay disc. indifference point, 0s delay2.52.79.5-2.9-0.8-1.13.11.10.90.11.71.2-0.42.0
Delay disc. indifference point, 16s delay1.31.53.0-1.2-1.3-1.61.71.41.50.20.61.4-0.40.9
Delay disc. indifference point, 2s delay3.53.98.8-1.8-1.1-1.03.02.11.8-0.02.42.1-1.62.7
Delay disc. indifference point, 24s delay1.51.62.9-1.4-1.1-1.71.61.51.40.80.71.3-0.51.3
Delay disc. indifference point, 4s delay4.64.810.6-1.8-1.7-1.53.22.62.2-0.12.42.7-1.52.6
Delay disc. indifference point, 8s delay1.82.13.3-0.3-0.8-1.61.81.71.51.31.21.7-1.41.7
Indifference point function ln k0.20.31.1-0.00.1-0.20.50.30.60.30.50.3-1.01.1
Indifference point function log k0.20.31.1-0.00.1-0.20.50.30.60.30.50.3-1.01.1
Patch foraging total patch changes 0 sec2.14.08.0-2.8-2.2-1.51.71.40.5-2.82.71.32.2-1.4
Patch foraging total patch changes 12 sec1.52.04.6-2.0-1.6-0.81.00.50.2-2.11.60.71.8-1.4
Patch foraging total patch changes 18 sec1.93.06.0-2.4-2.0-1.30.91.10.0-2.02.11.12.5-1.8
Patch foraging total patch changes 24 sec0.91.65.1-0.70.41.0-0.5-1.0-1.9-0.2-0.3-1.02.3-2.1
Patch foraging total patch changes 6 sec2.03.17.5-2.2-2.2-1.31.21.20.7-2.71.91.22.0-1.4
Patch foraging time to switch 0 sec0.20.51.30.30.90.5-0.4-0.7-0.21.1-0.6-0.6-0.90.6
Patch foraging water rate 0 sec0.92.04.5-1.3-2.0-1.50.71.10.8-2.11.21.11.7-1.2
Patch foraging water rate 12 sec0.10.10.4-0.1-0.4-0.50.20.60.20.40.10.50.4-0.1
Patch foraging water rate 18 sec0.81.24.90.30.4-0.40.50.61.11.10.50.5-2.21.9
Patch foraging water rate 24 sec0.10.20.70.4-0.2-0.4-0.80.10.20.1-0.80.0-0.1-0.3
Patch foraging water rate 6 sec0.40.61.30.8-0.6-1.1-0.21.11.00.10.01.1-0.90.7
Seeking ratio, delayed vs. immediate footshock0.60.83.81.50.10.0-0.90.30.7-0.1-0.50.2-2.00.7
Distance traveled before self-admin0.10.10.4-0.3-0.2-0.50.00.1-0.0-0.6-0.50.10.60.0
Distance traveled after self-admin0.20.21.0-0.0-0.2-0.40.30.40.40.7-0.10.5-0.61.0
Extensor digitorum longus weight1.87.212.6-2.4-3.6-3.42.22.83.0-3.03.12.90.20.0
Bone: elastic displacement0.60.71.80.70.81.0-1.0-1.3-0.70.1-0.9-1.30.0-0.3
Bone: elastic work0.20.20.90.1-0.1-0.30.30.30.7-0.20.90.3-0.70.6
Bone: endosteal estimation0.00.10.3-0.3-0.1-0.3-0.00.50.0-0.10.60.40.20.1
Bone: endosteal perimeter0.71.52.4-1.2-0.7-1.51.11.51.3-0.21.51.4-0.81.2
Epididymis fat weight0.41.33.5-1.9-1.3-1.41.00.81.2-1.11.40.9-0.20.6
Delta time in closed arm before/after self-admin7.67.111.63.13.12.7-2.6-2.6-2.23.4-2.9-2.7-2.20.8
Delta time in open arm before/after self-admin5.65.513.3-2.9-2.7-2.82.02.01.9-3.61.92.11.8-0.7
Diff in mean of infusions in LGA sessions0.30.31.1-0.20.20.30.3-0.20.10.80.3-0.2-1.01.0
Delay discount exponential model param4.14.510.41.91.62.0-3.2-2.5-2.1-0.7-2.1-2.61.2-2.3
Extinction: sum of active levers before priming0.10.10.6-0.1-0.2-0.3-0.3-0.00.1-0.8-0.7-0.00.1-0.3
Active lever presses in extinction session 60.60.62.40.70.60.50.2-0.5-0.10.80.5-0.3-1.61.1
Bone: final force0.20.30.9-0.5-1.0-0.5-0.20.30.3-0.70.40.20.6-0.5
Bone: final moment0.20.41.3-0.7-1.1-0.7-0.00.40.5-0.70.50.40.5-0.4
Food consumed during 24 hour testing period0.71.03.0-0.7-1.7-1.00.20.90.6-0.90.60.91.2-1.3
Glucose6.510.329.4-2.7-5.4-3.00.61.60.9-3.80.21.65.1-4.6
Heart weight0.61.03.8-1.3-0.9-0.1-0.3-0.4-0.5-1.4-0.1-0.41.9-1.5
Delay discount hyperbolic model param4.44.810.71.81.62.0-3.3-2.6-2.2-0.7-2.3-2.71.4-2.5
Intermittent access intake day 1-15 change0.71.44.7-1.5-1.2-0.80.71.10.7-2.2-0.11.01.7-1.0
Intermittent access intake escalation0.71.56.2-1.4-1.1-0.80.71.10.7-2.50.11.01.5-0.8
Intermittent access intake escalation 20.80.93.9-0.7-0.5-0.50.20.50.1-2.0-0.10.51.7-1.2
Intermitt. access day 1 inactive lever presses0.10.41.70.40.50.2-0.2-0.2-0.31.3-0.9-0.3-0.90.8
Intermitt. access day 15 inactive lever presses1.02.15.5-1.8-1.6-1.61.01.61.3-2.40.21.51.3-0.5
Intermitt. access escalation Index0.60.84.1-1.3-0.5-0.00.30.2-0.2-1.0-0.20.12.0-1.3
Intermittent access day 1 total infusions0.30.51.90.50.2-0.00.40.30.21.40.50.3-1.41.2
Intermittent access day 15 total infusions0.91.33.7-1.3-1.1-1.01.21.31.0-1.90.71.20.6-0.1
Intermittent access terminal intake (last 3 days)0.70.94.5-1.0-0.7-0.60.60.80.4-2.10.40.71.2-0.8
Intermittent access total infusions0.30.40.7-0.6-0.6-0.70.70.80.7-0.80.60.80.00.1
Intermittent access day 1 locomotion1.31.75.82.40.70.4-1.3-0.30.11.7-0.4-0.4-2.40.9
Intermittent access day 15 total locomotion0.30.61.3-0.6-0.9-1.10.40.91.1-0.80.10.8-0.80.5
Intermittent access total locomotion0.50.61.30.5-0.7-1.10.31.01.2-0.20.90.9-1.00.4
Intermittent access standard deviation0.91.84.91.01.21.2-2.0-1.3-1.2-0.4-2.2-1.30.6-1.3
Left kidney weight0.20.92.70.0-0.1-0.80.10.61.30.90.70.6-1.61.6
Right kidney weight0.21.04.0-0.70.2-0.60.50.21.11.00.60.2-1.82.0
Cocaine induced anxiety1.42.13.6-1.7-1.9-1.81.21.51.6-1.81.01.50.7-0.2
Post-drug Anxiety2.22.37.2-2.7-1.7-1.71.91.41.5-1.01.21.40.30.7
Baseline Anxiety0.50.61.9-0.90.50.30.6-0.3-0.01.10.1-0.2-1.11.4
Tail length1.97.212.3-1.3-3.1-3.42.43.43.2-2.23.53.3-0.60.7
Length with tail1.88.013.6-2.0-3.3-3.52.73.53.2-2.23.73.4-0.51.0
Length without tail0.51.64.6-2.1-1.2-1.51.40.91.3-0.61.51.0-0.31.0
Times rat made contact with spout2.83.211.10.1-0.21.3-1.6-1.6-2.0-0.7-1.4-1.52.9-3.3
Lifetime Intake0.30.31.1-0.2-0.5-0.60.40.70.7-1.00.60.7-0.30.1
Liver weight, left0.50.91.81.11.30.7-1.1-0.5-0.11.2-0.7-0.6-1.30.8
Liver weight, right1.11.94.32.11.81.0-1.7-1.1-0.41.3-1.0-1.2-1.80.7
Locomotor activity0.61.03.2-0.7-0.9-0.30.10.3-0.3-1.60.70.11.8-1.6
Locomotor testing distance0.50.92.4-0.6-0.9-0.71.31.20.5-1.21.61.10.20.2
Locomotor testing rearing1.12.24.9-1.6-2.1-1.51.21.40.8-2.21.11.41.5-0.6
Locomotion in novel chamber1.82.45.50.72.32.0-0.3-1.9-1.91.90.0-2.0-0.80.7
Locomotion in novel chamber post-restriction1.52.44.31.52.11.7-1.3-1.6-1.42.1-1.8-1.5-0.80.5
Fecal boli incidents, locomotor time 10.20.31.11.10.30.5-1.0-0.4-0.10.3-0.6-0.4-0.3-0.1
Change in fecal boli incidents, locomotor task0.50.52.1-0.4-0.6-0.9-0.20.0-0.2-0.40.20.11.2-1.5
Time >=10cm from walls, locomotor time 10.30.30.8-0.60.50.00.2-0.7-0.50.8-0.9-0.8-0.00.5
Bouts of movement, locomotor time 10.91.04.9-2.2-0.8-0.51.40.4-0.3-0.50.30.51.6-0.4
Total resting periods, locomotor time 10.40.52.6-1.6-0.4-0.00.70.1-0.4-0.4-0.30.01.2-0.5
Rest time, locomotor task time 10.10.21.10.00.10.4-0.4-0.2-0.20.5-1.00.00.1-0.2
Distance moved, locomotor task time 10.20.30.90.3-0.6-0.80.10.40.9-0.70.70.5-0.50.1
Vertical activity count, locomotor time 10.10.10.70.1-0.3-0.50.10.30.3-0.60.80.1-0.0-0.2
Time >=10cm from walls, locomotor time 20.81.26.11.11.00.1-0.2-0.2-0.22.5-1.1-0.2-1.31.2
Bouts of movement, locomotor time 21.72.64.50.2-0.6-1.41.62.11.71.61.71.8-1.92.0
Total resting periods, locomotor time 21.42.44.4-0.1-0.7-1.61.72.11.51.31.71.9-1.51.7
Rest time, locomotor task time 20.30.40.9-0.3-0.00.3-0.6-0.7-0.6-0.3-0.9-0.80.9-0.9
Distance moved, locomotor task time 20.10.10.60.60.50.1-0.2-0.2-0.10.8-0.1-0.0-0.40.3
Vertical activity count, locomotor time 20.20.31.10.60.90.50.1-0.3-0.21.00.3-0.4-0.70.6
Light reinforcement 10.20.40.9-0.2-0.4-0.70.81.00.60.70.70.9-0.50.5
Light reinforcement 21.11.75.10.60.4-0.51.11.41.30.51.21.3-2.32.2
Bone: marrow area0.00.10.2-0.30.1-0.2-0.00.4-0.00.00.50.30.10.2
Bone: maximum diameter2.14.07.1-2.2-2.6-2.71.72.12.0-1.92.51.90.50.2
Bone: maximum force0.10.20.5-0.6-0.7-0.60.20.50.5-0.10.60.40.10.2
Bone: maximum moment0.20.30.7-0.7-0.8-0.80.40.60.7-0.10.80.60.00.3
Mean time between licks in bursts0.20.41.30.2-0.8-0.60.10.5-0.00.20.80.41.1-1.1
Mean num. licks in bursts3.45.39.01.81.32.2-3.0-2.9-2.40.9-2.6-2.71.6-2.8
Cd content in liver0.60.62.2-0.9-1.3-0.70.20.40.2-1.50.30.30.9-0.7
Co content in liver1.11.32.8-1.6-1.3-1.21.11.00.7-1.71.31.00.40.1
Cu content in liver0.20.20.7-0.3-0.8-0.3-0.50.0-0.1-0.0-0.1-0.10.8-0.8
Fe content in liver0.91.12.91.71.61.2-0.9-0.8-0.91.1-0.4-0.8-0.70.1
K content in liver2.32.24.7-0.8-0.8-1.81.51.72.20.81.01.5-1.51.9
Mg content in liver0.50.51.8-1.4-0.5-0.90.80.50.80.30.20.2-0.31.0
Mn content in liver0.40.51.00.5-0.3-0.80.10.91.0-0.60.40.8-0.80.7
Na content in liver2.02.24.9-1.8-1.5-1.72.21.71.6-0.31.41.70.10.9
Rb content in liver0.60.72.1-1.2-1.3-1.40.30.51.1-0.40.20.50.20.2
Se content in liver1.21.43.0-0.6-1.1-1.51.41.31.7-0.41.31.4-0.80.9
Sr content in liver3.73.26.3-2.4-2.0-1.92.21.71.8-1.02.51.70.20.9
Zn content in liver0.80.82.6-0.0-0.5-1.20.00.81.60.60.50.6-1.41.2
Bone: minimum diameter0.10.10.40.20.3-0.3-0.6-0.30.20.3-0.1-0.3-0.60.4
Time in familiar zone, hab. session 10.00.00.1-0.00.2-0.00.10.3-0.1-0.3-0.20.3-0.10.1
Time in novel zone, hab. session 10.10.10.5-0.1-0.4-0.0-0.2-0.40.1-0.30.3-0.40.5-0.7
Total zone transitions, hab. session 10.10.21.41.2-0.0-0.1-0.60.20.20.50.20.0-0.2-0.2
Total locomotion distance, hab. session 10.60.92.00.8-0.0-0.80.61.21.00.21.41.0-1.11.1
Locomotion velocity, hab. session 10.30.51.20.80.2-0.40.30.80.60.41.10.7-0.90.8
Time in familiar zone, hab. session 21.01.12.30.51.21.1-1.1-1.3-1.00.9-1.5-1.4-0.1-0.1
Time in novel zone, hab. session 21.11.12.6-0.4-1.6-1.00.71.10.8-1.31.31.10.9-0.8
Total zone transitions, hab. session 20.91.12.70.8-0.9-1.20.41.41.60.31.21.3-1.00.7
Total locomotion distance, hab. session 21.01.32.90.1-1.1-1.40.81.61.7-0.01.21.4-0.90.9
Locomotion velocity, hab. session 21.52.14.3-0.0-1.2-1.71.11.92.10.01.51.8-1.31.4
Novel to familiar place preference ratio0.10.20.70.2-0.5-0.2-0.10.3-0.20.2-0.20.30.8-0.6
Novelty place preference0.20.20.80.3-0.5-0.2-0.30.1-0.30.1-0.30.10.9-0.8
Time in novel zone, NPP test0.20.31.10.2-0.5-0.1-0.4-0.0-0.4-0.0-0.2-0.11.1-1.0
Total zone transitions, NPP test0.50.82.81.10.70.0-0.20.10.71.20.40.1-1.71.3
Total locomotion distance, NPP test0.81.13.60.50.4-0.50.70.81.20.80.70.8-1.91.8
Locomotion velocity, NPP test1.01.44.00.40.2-0.70.91.11.40.80.81.0-2.02.0
Intraocular pressure0.40.62.0-0.4-0.9-0.80.70.80.3-1.40.80.60.5-0.4
Delta distance traveled before/after self-admin0.70.73.60.50.80.7-0.2-0.4-0.31.9-0.2-0.3-1.31.0
Delta ambulatory time before/after self-admin0.50.72.90.60.80.9-0.2-0.5-0.31.70.1-0.4-1.20.8
Parametrial fat weight0.71.75.2-1.8-2.3-1.70.21.11.6-1.2-0.21.10.9-0.7
Pavlov. Cond. lever latency0.20.30.8-0.9-0.5-0.20.3-0.1-0.3-0.80.0-0.10.9-0.6
Pavlov. Cond. magazine entry latency0.91.22.21.41.51.4-1.2-1.0-1.20.8-1.0-1.0-0.2-0.3
Pavlov. Cond. change in total contacts1.01.12.2-0.1-1.5-1.30.61.31.2-0.91.41.30.1-0.2
Pavlov. Cond. index score0.60.81.91.41.31.0-0.9-0.7-0.61.0-0.7-0.6-0.80.3
Pavlov. Cond. latency score0.60.82.01.41.20.9-0.9-0.6-0.41.1-0.6-0.6-0.90.4
Pavlov. Cond. lever contacts0.30.41.31.10.70.4-0.5-0.10.10.7-0.3-0.1-0.90.5
Pavlov. Cond. magazine entry number0.91.21.9-1.4-1.2-1.31.41.11.2-0.51.11.1-0.10.8
Pavlov. Cond. intertrial magazine entries1.92.34.9-0.0-0.2-0.81.52.11.70.41.62.1-2.02.2
Pavlov. Cond. lever-magazine prob. diff.0.81.02.51.61.41.1-1.1-0.8-0.61.1-0.8-0.7-0.90.3
Pavlov. Cond. response bias0.20.31.01.00.70.4-0.6-0.2-0.20.5-0.3-0.2-0.60.1
Pavlov. Cond. lever latency2.83.87.1-1.6-1.9-2.62.22.02.7-0.51.82.0-1.32.0
Pavlov. Cond. magazine entry latency0.10.10.2-0.20.40.30.10.1-0.50.4-0.20.10.2-0.0
Pavlov. Cond. change in total contacts0.20.30.70.60.60.8-0.8-0.4-0.70.1-0.1-0.40.3-0.6
Pavlov. Cond. index score0.81.12.20.81.21.5-1.2-0.9-1.50.5-0.8-0.90.6-1.0
Pavlov. Cond. latency score0.81.02.30.81.31.5-1.2-0.9-1.40.6-0.8-0.90.4-0.8
Pavlov. Cond. lever contacts2.94.07.41.72.12.6-2.2-2.0-2.70.6-1.9-2.01.2-1.9
Pavlov. Cond. magazine entry number0.60.71.80.1-0.2-0.70.80.71.10.10.90.7-1.31.4
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.0-0.3-0.60.10.20.50.00.10.10.00.3
Pavlov. Cond. lever-magazine prob. diff.1.01.32.60.81.31.6-1.3-1.1-1.60.5-0.8-1.10.7-1.0
Pavlov. Cond. response bias1.92.55.01.21.42.0-1.8-1.5-2.20.4-1.4-1.51.4-1.9
Time in closed arm before self-admin0.20.31.30.2-0.5-0.40.30.60.50.71.20.6-0.1-0.2
Time in closed arm after self-admin1.92.08.41.61.51.4-1.1-1.0-1.02.9-1.0-1.0-1.30.5
Time in open arm before self-admin0.70.72.00.71.11.4-0.2-0.6-1.01.0-0.6-0.6-0.60.7
Time in open arm after self-admin0.50.63.3-0.3-0.8-0.7-0.00.40.4-1.8-0.30.60.9-0.6
Bone: periosteal estimation0.40.92.2-1.0-0.9-1.20.71.11.0-0.61.51.0-0.30.7
Bone: periosteal perimeter1.52.54.2-1.5-1.2-2.11.71.81.8-0.42.01.7-1.01.5
Bone: post-yield work0.10.20.5-0.7-0.1-0.10.60.20.10.70.30.30.00.6
Progressive ratio test 1 active lever presses0.30.40.90.3-0.4-0.70.30.80.80.60.20.8-1.00.7
Progressive ratio test 1 breakpoint0.40.51.00.3-0.5-0.80.40.80.80.60.30.8-1.00.7
Progressive ratio test 1 inactive lever presses2.33.36.7-0.9-2.1-2.31.32.32.6-0.80.92.3-1.61.5
Progressive ratio test 2 active lever presses0.50.51.2-0.9-0.6-0.71.10.80.5-0.81.00.70.30.1
Progressive ratio test 2 breakpoint0.50.51.2-1.0-0.5-0.61.10.70.5-0.81.00.70.4-0.0
Progressive ratio test 2 inactive lever presses0.71.11.9-1.1-1.1-1.30.91.31.4-0.20.01.2-0.91.1
Incentive Sensitization - Responses0.71.03.3-1.8-0.6-0.31.40.60.4-1.51.40.50.60.1
Incentive Sensitization - Breakpoint0.81.03.7-1.9-0.5-0.21.40.50.2-1.61.30.40.8-0.0
Sum of active levers in priming session hrs 5-60.70.61.2-0.7-0.6-0.61.10.50.8-0.71.10.6-0.80.9
Progressive ratio0.30.51.71.00.6-0.1-0.7-0.50.20.8-0.8-0.5-1.30.7
Food seeking constrained by brief footshock2.73.46.6-1.3-1.4-2.21.81.82.40.51.01.9-2.12.6
Seeking ratio, punishment vs. effort1.21.83.6-1.0-1.4-1.21.61.91.4-0.11.61.9-0.41.0
Retroperitoneal fat weight0.31.53.6-1.9-1.8-1.60.71.31.3-1.20.41.10.40.2
Reaction time number correct0.10.21.2-0.1-0.4-0.1-0.1-0.2-0.5-0.2-0.3-0.21.1-0.9
Reaction time mean minus median1.12.74.70.21.51.7-1.6-1.9-2.21.7-1.9-2.01.3-1.2
Reaction time mean minus median AUC0.82.14.30.01.31.6-1.1-1.5-2.11.8-1.7-1.51.3-0.9
Reaction time num false alarms1.11.53.9-1.3-1.0-1.22.01.31.2-0.71.51.2-0.50.9
Reaction time num false alarms AUC1.21.95.2-1.5-0.8-1.22.31.21.4-0.51.81.2-0.91.5
Reaction time trials correct on left0.10.21.2-0.1-0.4-0.1-0.1-0.2-0.5-0.2-0.3-0.21.1-0.9
Reaction time trials on left0.10.21.2-0.1-0.3-0.1-0.1-0.2-0.5-0.1-0.3-0.21.1-0.9
Reaction time mean0.60.92.10.11.31.1-0.4-1.3-0.80.9-1.3-1.4-0.10.2
Reaction time mean AUC0.81.32.50.21.61.3-0.5-1.4-1.01.2-1.5-1.6-0.30.4
Median of all reaction times0.40.61.30.31.10.8-0.2-1.0-0.30.5-1.1-1.1-0.60.6
Reaction time omissions0.60.92.00.31.01.2-0.5-1.3-1.10.7-1.1-1.40.4-0.2
Reaction time false alarm rate1.52.04.8-1.3-0.6-1.12.21.31.6-0.31.81.3-1.31.8
Reaction time premature initiation rate1.72.45.22.32.11.8-2.2-1.1-1.11.1-1.3-1.2-1.20.1
Reaction time premature initiations0.81.53.81.81.51.4-1.9-1.0-1.20.6-1.1-1.0-0.3-0.5
Std. dev. reaction times1.01.83.4-0.21.41.4-0.9-1.7-1.71.4-1.8-1.80.8-0.5
Reaction time trials completed0.10.21.2-0.1-0.3-0.1-0.1-0.2-0.5-0.1-0.3-0.21.1-0.9
Reaction time trials AUC0.10.21.0-0.1-0.4-0.20.0-0.1-0.3-0.2-0.2-0.11.0-0.7
Run reversals in cocaine runway, females0.90.94.3-0.80.70.20.80.1-0.32.1-0.30.1-0.71.7
Run reversals in cocaine runway, males0.10.10.2-0.2-0.5-0.3-0.10.30.30.20.00.30.2-0.4
Latency to leave start box in cocaine runway0.50.61.4-0.9-0.7-0.61.20.70.9-0.60.70.7-0.41.0
Latency to leave start box in cocaine runway, F1.82.05.3-1.7-1.2-1.52.31.31.3-0.61.81.3-0.41.4
Latency to leave start box in cocaine runway, M0.50.51.70.90.31.0-1.1-0.5-0.2-0.4-1.3-0.5-0.2-0.1
Std. dev. time between licks in bursts0.20.20.50.3-0.2-0.20.30.7-0.30.60.60.70.6-0.5
Total sessions with >9 infusions1.21.43.71.91.31.4-1.6-1.1-1.00.9-1.0-1.1-0.7-0.3
Short access day 1 total inactive lever presses1.31.83.7-0.6-1.8-1.90.71.81.8-1.40.51.6-0.20.3
Short access day 10 total inactive lever presses0.10.31.50.0-0.4-0.6-0.40.40.50.2-1.20.4-0.50.4
Short access day 1 total infusions1.11.53.92.01.00.9-1.8-0.9-0.61.3-1.5-1.0-1.20.1
Short access day 10 total infusions0.30.41.01.00.90.9-0.4-0.5-0.60.70.2-0.5-0.80.2
Short access total infusions0.20.21.01.00.30.3-0.7-0.2-0.1-0.20.0-0.2-0.5-0.3
Short access day 1 locomotion1.62.06.42.51.11.1-1.5-0.8-0.52.0-0.4-0.8-2.20.7
Short access day 10 total locomotion2.03.710.73.31.50.7-2.3-1.0-0.53.3-1.1-1.0-2.70.7
Short access total locomotion2.42.910.33.21.51.2-2.3-1.2-1.02.1-1.1-1.2-1.6-0.2
One hour access (0.3 mA shock)0.40.41.0-0.2-0.6-1.00.60.81.0-0.10.60.7-0.60.4
Compulsive drug intake0.80.92.11.11.21.4-0.5-1.3-1.30.5-0.1-1.2-0.1-0.1
One hour access (shock baseline)0.30.41.2-0.7-0.7-1.10.40.81.0-0.10.20.7-0.30.2
Social response proportion0.50.61.7-0.1-1.1-1.10.30.81.3-0.20.70.9-0.40.1
Social responses1.01.33.3-1.0-1.8-1.70.81.21.3-0.50.91.20.6-0.7
Social time0.10.20.6-0.6-0.8-0.50.1-0.10.50.4-0.4-0.10.3-0.3
Soleus weight0.92.74.6-1.0-1.0-2.01.81.72.2-0.42.11.6-1.61.8
Bone: stiffness0.10.10.40.10.20.2-0.7-0.1-0.40.3-0.4-0.20.2-0.2
Tibialis anterior weight0.82.74.7-2.2-2.1-1.71.61.41.3-2.02.01.60.50.0
Time to tail flick, vehicle, before self-admin0.70.73.80.50.0-0.3-0.20.20.91.0-0.40.2-2.01.3
Time to tail flick, vehicle, after self-admin0.50.73.9-0.30.1-0.70.40.20.52.0-0.3-0.0-1.01.1
Time to tail flick, test, before self-admin0.50.51.70.30.40.7-0.5-0.6-0.8-0.7-0.1-0.41.2-1.3
Time to tail flick, test, after self-admin2.02.14.20.3-1.7-1.71.12.11.9-0.51.61.9-1.00.8
Delta time to tail flick, vehicle, before/after SA0.30.32.4-0.40.40.00.4-0.2-0.31.60.1-0.3-0.20.5
Delta time to tail flick, test, before/after SA1.31.32.6-0.1-1.4-1.60.81.61.6-0.10.71.3-0.90.9
Tibia length0.30.83.20.20.7-0.30.70.70.70.60.90.6-1.61.8
Ambulatory time before self-admin0.30.41.0-0.8-0.6-1.00.70.60.4-0.90.10.60.50.4
Ambulatory time after self-admin0.20.20.90.50.1-0.10.00.10.30.60.10.2-0.91.0
Bone: tissue strength1.01.02.80.1-0.20.5-1.0-0.8-1.1-0.9-0.7-0.91.6-1.7
Total heroin consumption0.10.20.30.60.30.3-0.6-0.5-0.0-0.40.1-0.4-0.3-0.2
Bone: trabecular number0.00.00.00.10.20.2-0.2-0.2-0.2-0.10.1-0.10.1-0.1
Bone: trabecular spacing0.70.92.6-1.3-0.9-1.11.60.90.9-0.10.71.10.10.6
Bone: trabecular thickness0.40.51.20.71.10.8-0.4-0.0-0.20.90.1-0.2-1.10.9
Bone: trabecular tissue density0.60.91.40.20.61.0-1.2-1.0-1.21.1-1.2-0.90.8-0.7
Water consumed over 24 hours0.60.92.7-0.5-1.2-0.40.10.4-0.1-1.40.30.51.6-1.6
Number of responses in last shaping day0.30.31.00.90.00.1-0.50.10.10.9-0.5-0.0-1.00.7