H2az2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression H2az2 0.18 0.12 9.7e-03 0.01 0.01 0.03 0.01 1.6e-01 1.4e-01 5.7e-02 1.6e-01
2 Liver mRNA stability H2az2 0.07 0.05 9.2e-04 0.03 0.01 0.01 0.02 6.8e-04 1.3e-02 1.6e-02 6.5e-03
3 Liver isoform ratio XM_039092453.2 0.07 0.04 2.1e-05 0.04 0.04 0.03 0.03 2.8e-05 3.3e-05 1.4e-04 3.4e-04
4 PL mRNA stability H2az2 0.03 0.02 1.4e-03 0.03 0.02 0 0.02 3.0e-04 2.5e-03 1.3e-01 1.2e-03
5 NAcc mRNA stability H2az2 0.06 0.04 2.5e-06 0.04 0.04 0.04 0.04 2.3e-07 4.8e-06 9.8e-07 1.1e-06
6 pVTA mRNA stability H2az2 0.13 0.09 7.5e-05 0.04 0.04 0.04 0.05 2.2e-04 3.0e-04 6.6e-04 5.6e-05
7 Brain gene expression H2az2 0.05 0.03 7.3e-03 0.01 0.02 0.03 0.02 2.9e-02 2.5e-03 4.7e-04 8.6e-03
8 Liver isoform ratio XM_017599381.3 0.02 0.01 9.1e-03 0.01 0.01 0.01 0.01 1.3e-02 1.4e-02 7.1e-02 1.9e-02
9 Brain mRNA stability H2az2 0.31 0.22 4.2e-12 0.15 0.11 0.12 0.14 1.1e-13 1.8e-10 4.3e-11 6.1e-13
10 RMTg intron excision ratio chr14_85509589_85514289 0.32 0.15 1.9e-03 0.11 0.05 0.08 0.11 9.3e-04 2.0e-02 4.3e-03 6.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.00.1-0.2-0.3-0.40.20.1-0.20.0-0.30.0-0.0
Area under the delay curve2.94.510.81.91.62.0-3.3-2.52.2-0.6-2.1-2.5-1.3
BMI with tail0.20.63.01.70.90.9-0.9-0.20.7-0.10.2-0.2-0.2
BMI without tail0.21.01.91.11.21.3-0.9-1.21.40.4-0.5-1.0-0.5
Body weight1.46.39.13.02.73.0-2.7-2.72.81.2-2.5-2.6-0.8
Weight adjusted by age0.10.30.60.70.50.4-0.8-0.70.5-0.3-0.6-0.6-0.3
Bone surface0.10.20.40.40.40.2-0.1-0.4-0.00.6-0.6-0.30.6
Bone volume0.10.20.60.60.50.3-0.3-0.50.10.7-0.8-0.40.5
Breakpoint value in progressive ratio session0.20.31.30.40.50.2-0.6-0.30.40.7-1.1-0.4-0.0
Number of licking bursts1.23.56.12.21.71.7-2.5-2.21.41.5-2.1-2.10.3
Context. condit. distance diff. score1.82.24.1-1.1-1.8-1.81.21.7-2.0-1.01.31.70.6
Locomotion velocity, session 10.50.62.2-1.5-0.2-0.71.20.5-0.7-0.10.70.60.6
Locomotion distance, session 10.91.13.6-1.9-0.9-0.30.3-0.30.6-1.4-0.7-0.2-1.9
Locomotion velocity, session 20.91.12.9-1.50.2-0.61.50.8-1.10.80.60.81.7
Locomotion distance, session 20.91.34.4-2.1-1.1-1.01.70.8-0.4-0.80.90.9-0.7
Locomotion velocity, session 31.01.23.0-1.7-1.4-1.01.01.0-1.1-0.90.71.0-0.3
Locomotion distance, session 30.30.41.20.30.81.1-0.7-0.60.50.5-0.5-0.60.2
Stereotopy head waving bouts, day 30.60.73.6-1.9-0.7-0.71.20.5-0.3-0.20.20.6-0.3
Stereotopy head waving duration, day 32.02.55.5-2.4-1.6-1.92.11.6-1.4-0.71.21.6-0.0
Locomotion velocity, session 70.20.20.7-0.20.50.4-0.1-0.40.20.8-0.4-0.40.2
Locomotion distance, session 70.00.10.2-0.0-0.3-0.40.00.1-0.40.10.00.20.3
Stereotopy head waving bouts, day 70.10.10.4-0.2-0.3-0.3-0.10.3-0.6-0.30.20.20.5
Stereotopy head waving duration, day 70.10.10.3-0.5-0.3-0.20.10.1-0.2-0.40.0-0.0-0.1
Locomotion velocity, session 81.21.42.8-1.7-1.0-1.21.51.0-1.7-0.50.61.01.1
Locomotion distance, session 84.76.89.7-3.1-3.0-2.93.02.7-2.6-2.02.52.80.1
Degree of sensitization distance2.02.14.9-1.0-1.7-2.21.41.4-1.9-0.81.21.50.5
Degree of sensitization stereotypy0.00.10.20.30.10.1-0.4-0.1-0.2-0.2-0.1-0.20.3
Conditioned locomotion0.60.73.6-1.1-1.0-0.20.2-0.30.4-1.0-0.5-0.4-1.9
Cocaine response after cond. corrected1.01.63.40.91.21.3-1.5-1.51.00.8-1.8-1.60.3
Cocaine response after cond. not corrected1.42.14.31.21.31.4-1.9-1.61.21.0-2.1-1.7-0.0
Cocaine response before conditioning0.10.10.4-0.0-0.7-0.4-0.10.3-0.2-0.30.30.3-0.6
Saline control response0.20.30.7-0.6-0.3-0.40.80.5-0.7-0.00.40.50.5
Bone: connectivity density0.10.20.5-0.4-0.5-0.70.40.6-0.50.00.20.70.2
Bone: cortical apparent density0.20.40.80.70.90.8-0.8-0.50.60.4-0.1-0.50.3
Bone: cortical area1.62.64.41.61.72.0-1.6-1.71.91.0-2.1-1.6-0.6
Bone: cortical porosity0.00.00.2-0.40.1-0.40.40.00.0-0.0-0.0-0.1-0.0
Bone: cortical porosity0.10.10.4-0.3-0.4-0.60.20.1-0.1-0.50.00.0-0.4
Bone: cortical thickness1.32.23.91.31.41.6-1.6-1.51.80.7-2.0-1.5-0.9
Bone: cortical thickness0.40.51.50.1-0.9-0.7-0.8-0.3-0.1-1.0-0.7-0.4-1.2
Bone: cortical tissue density0.30.40.90.81.00.8-0.9-0.50.60.5-0.1-0.50.4
Condit. Reinf. active minus inactive responses0.91.03.10.71.50.9-0.6-0.80.51.8-0.4-0.81.1
Condit. Reinf. active-inactive response ratio1.01.04.10.50.5-0.50.50.9-1.11.30.80.92.0
Condit. Reinf. active responses0.50.72.00.21.10.7-0.5-1.00.61.4-0.5-1.00.4
Condit. Reinf. inactive responses0.81.02.30.10.50.9-0.9-1.51.10.3-1.2-1.5-0.9
Incentive salience index mean1.41.83.00.91.71.5-1.2-1.61.31.7-1.2-1.60.3
Condit. Reinf. lever presses1.21.73.40.00.81.4-1.0-1.81.80.5-1.4-1.8-1.3
Condit. Reinf. active minus inactive responses0.10.20.4-0.6-0.6-0.60.70.2-0.5-0.40.20.2-0.2
Condit. Reinf. active-inactive response ratio0.10.20.50.10.20.3-0.3-0.70.4-0.3-0.6-0.6-0.4
Condit. Reinf. active responses0.40.61.5-1.1-0.9-0.81.20.6-0.6-0.40.70.7-0.2
Condit. Reinf. inactive responses1.01.52.7-1.2-1.1-1.31.61.4-1.3-0.11.31.40.4
Condit. Reinf. lever presses0.10.20.5-0.6-0.7-0.60.30.1-0.5-0.4-0.10.1-0.1
Condit. Reinf. lever reinforcers received0.20.30.9-0.9-0.7-0.71.00.3-0.5-0.20.20.4-0.2
Conditioned reinforcement - actives0.00.10.70.20.30.00.1-0.20.20.90.3-0.1-0.2
Conditioned reinforcement - inactives0.10.40.90.70.60.4-0.6-0.70.51.0-0.0-0.7-0.0
Conditioned locomotion0.60.92.20.31.21.0-0.2-1.11.21.5-0.2-1.0-0.5
Patch foraging indifference point 0 sec1.43.97.72.82.11.5-1.8-1.30.62.5-2.7-1.32.0
Patch foraging indifference point AUC0.10.21.3-0.20.4-0.00.3-0.3-0.21.1-0.1-0.40.7
Delay disc. indifference point, 0s delay2.32.69.52.90.81.1-3.1-1.10.9-0.1-1.7-1.2-0.4
Delay disc. indifference point, 16s delay1.11.53.01.21.31.6-1.7-1.41.5-0.2-0.6-1.4-0.4
Delay disc. indifference point, 2s delay3.23.58.81.81.11.0-3.0-2.11.80.0-2.4-2.1-1.6
Delay disc. indifference point, 24s delay1.01.62.91.41.11.7-1.6-1.51.4-0.8-0.7-1.3-0.5
Delay disc. indifference point, 4s delay4.44.610.61.81.71.5-3.2-2.62.20.1-2.4-2.7-1.5
Delay disc. indifference point, 8s delay1.22.03.30.30.81.6-1.8-1.71.5-1.3-1.2-1.7-1.4
Indifference point function ln k0.10.21.00.0-0.10.2-0.5-0.30.6-0.3-0.5-0.3-1.0
Indifference point function log k0.10.21.00.0-0.10.2-0.5-0.30.6-0.3-0.5-0.3-1.0
Patch foraging total patch changes 0 sec1.44.28.02.82.21.5-1.7-1.40.52.8-2.7-1.32.2
Patch foraging total patch changes 12 sec1.52.04.62.01.60.8-1.0-0.50.22.1-1.6-0.71.8
Patch foraging total patch changes 18 sec1.33.06.02.42.01.3-0.9-1.1-0.02.0-2.1-1.12.5
Patch foraging total patch changes 24 sec0.41.35.10.7-0.4-1.00.51.0-1.90.20.31.02.3
Patch foraging total patch changes 6 sec1.93.27.52.22.21.3-1.2-1.20.72.7-1.9-1.22.0
Patch foraging time to switch 0 sec0.10.51.3-0.3-0.9-0.50.40.7-0.2-1.10.60.6-0.9
Patch foraging water rate 0 sec0.52.14.51.32.01.5-0.7-1.10.82.1-1.2-1.11.7
Patch foraging water rate 12 sec0.00.10.40.10.40.5-0.2-0.60.2-0.4-0.1-0.50.4
Patch foraging water rate 18 sec0.40.94.9-0.3-0.40.4-0.5-0.61.2-1.1-0.5-0.5-2.2
Patch foraging water rate 24 sec0.10.20.7-0.40.20.40.8-0.10.2-0.10.8-0.0-0.1
Patch foraging water rate 6 sec0.40.61.3-0.80.61.10.2-1.11.0-0.1-0.0-1.1-0.9
Seeking ratio, delayed vs. immediate footshock0.50.83.8-1.5-0.1-0.00.9-0.30.70.10.5-0.2-2.0
Distance traveled before self-admin0.10.10.40.30.20.5-0.0-0.1-0.00.60.5-0.10.6
Distance traveled after self-admin0.10.20.40.00.20.4-0.3-0.40.4-0.70.1-0.5-0.6
Extensor digitorum longus weight2.07.912.62.43.63.4-2.2-2.83.03.0-3.1-2.90.2
Bone: elastic displacement0.60.81.8-0.7-0.8-1.01.01.3-0.7-0.10.91.30.0
Bone: elastic work0.20.20.9-0.10.10.3-0.3-0.30.70.2-0.9-0.3-0.7
Bone: endosteal estimation0.00.10.30.30.10.30.0-0.50.00.1-0.6-0.40.2
Bone: endosteal perimeter0.61.52.41.20.71.5-1.1-1.51.30.2-1.5-1.4-0.8
Epididymis fat weight0.31.43.51.91.31.4-1.0-0.81.21.1-1.4-0.9-0.2
Delta time in closed arm before/after self-admin8.27.711.6-3.1-3.1-2.72.62.6-2.2-3.42.92.7-2.2
Delta time in open arm before/after self-admin5.16.013.32.92.72.8-2.0-2.01.93.6-1.9-2.11.8
Diff in mean of infusions in LGA sessions0.10.21.10.2-0.2-0.3-0.30.20.1-0.8-0.30.2-1.0
Delay discount exponential model param3.34.410.4-1.9-1.6-2.03.22.5-2.10.72.12.61.2
Extinction: sum of active levers before priming0.10.10.60.10.20.30.30.00.10.80.70.00.1
Active lever presses in extinction session 60.50.52.4-0.7-0.6-0.5-0.20.5-0.1-0.8-0.50.3-1.6
Bone: final force0.20.30.90.51.00.50.2-0.30.30.7-0.4-0.20.6
Bone: final moment0.20.41.30.71.10.70.0-0.40.50.7-0.5-0.40.5
Food consumed during 24 hour testing period0.40.93.00.71.71.0-0.2-0.90.60.9-0.6-0.91.2
Glucose5.89.229.42.75.43.0-0.6-1.60.93.8-0.2-1.65.1
Heart weight0.50.93.81.30.90.10.30.4-0.51.40.10.41.9
Delay discount hyperbolic model param3.74.710.7-1.8-1.6-2.03.32.6-2.20.72.32.71.4
Intermittent access intake day 1-15 change0.31.54.71.51.20.8-0.7-1.10.72.20.1-1.01.7
Intermittent access intake escalation0.31.56.21.41.10.8-0.7-1.10.72.5-0.1-1.01.5
Intermittent access intake escalation 20.50.83.90.70.50.5-0.2-0.50.12.00.1-0.51.7
Intermitt. access day 1 inactive lever presses0.00.41.7-0.4-0.5-0.20.20.2-0.3-1.30.90.3-0.9
Intermitt. access day 15 inactive lever presses0.42.35.51.81.61.6-1.0-1.61.32.4-0.2-1.51.3
Intermitt. access escalation Index0.20.74.11.30.50.0-0.3-0.2-0.21.00.2-0.12.0
Intermittent access day 1 total infusions0.20.51.9-0.5-0.20.0-0.4-0.30.2-1.4-0.5-0.3-1.4
Intermittent access day 15 total infusions0.61.43.71.31.11.0-1.2-1.31.01.9-0.7-1.20.6
Intermittent access terminal intake (last 3 days)0.61.04.51.00.70.6-0.6-0.80.42.1-0.4-0.71.2
Intermittent access total infusions0.40.40.70.60.60.7-0.7-0.80.70.8-0.6-0.80.0
Intermittent access day 1 locomotion1.01.85.8-2.4-0.7-0.41.30.30.1-1.70.40.4-2.4
Intermittent access day 15 total locomotion0.20.61.30.60.91.1-0.4-0.91.10.8-0.1-0.8-0.8
Intermittent access total locomotion0.60.71.3-0.50.71.1-0.3-1.01.20.2-0.9-0.9-1.0
Intermittent access standard deviation0.31.84.9-1.0-1.2-1.22.01.3-1.20.42.21.30.6
Left kidney weight0.10.72.7-0.00.10.8-0.1-0.61.3-0.9-0.7-0.6-1.6
Right kidney weight0.10.73.20.7-0.20.6-0.5-0.21.1-1.0-0.6-0.2-1.8
Cocaine induced anxiety0.82.33.61.71.91.8-1.2-1.51.61.8-1.0-1.50.7
Post-drug Anxiety2.22.57.22.71.71.7-1.9-1.41.51.0-1.2-1.40.3
Baseline Anxiety0.30.41.30.9-0.5-0.3-0.60.3-0.0-1.1-0.10.2-1.1
Tail length1.57.912.31.33.13.4-2.4-3.43.22.2-3.5-3.3-0.6
Length with tail2.08.713.62.03.33.5-2.7-3.53.22.2-3.7-3.4-0.5
Length without tail0.31.64.62.11.21.5-1.4-0.91.30.6-1.5-1.0-0.3
Times rat made contact with spout2.12.48.3-0.10.2-1.31.61.6-2.00.71.41.52.9
Lifetime Intake0.30.41.10.20.50.6-0.4-0.70.71.0-0.6-0.7-0.3
Liver weight, left0.50.91.8-1.1-1.3-0.71.10.5-0.1-1.20.70.6-1.3
Liver weight, right1.22.04.3-2.1-1.8-1.01.71.1-0.4-1.31.01.2-1.8
Locomotor activity0.50.83.20.70.90.3-0.1-0.3-0.31.6-0.7-0.11.8
Locomotor testing distance0.41.02.40.60.90.7-1.3-1.20.51.2-1.6-1.10.2
Locomotor testing rearing0.62.44.91.62.11.5-1.2-1.40.82.2-1.1-1.41.5
Locomotion in novel chamber1.92.55.5-0.7-2.3-2.00.31.9-1.9-1.9-0.02.0-0.8
Locomotion in novel chamber post-restriction0.92.64.3-1.5-2.1-1.71.31.6-1.4-2.11.81.5-0.8
Fecal boli incidents, locomotor time 10.10.31.1-1.1-0.3-0.51.00.4-0.1-0.30.60.4-0.3
Change in fecal boli incidents, locomotor task0.30.31.30.40.60.90.2-0.0-0.20.4-0.2-0.11.2
Time >=10cm from walls, locomotor time 10.30.40.80.6-0.5-0.0-0.20.7-0.5-0.80.90.8-0.0
Bouts of movement, locomotor time 10.91.14.92.20.80.5-1.4-0.4-0.30.5-0.3-0.51.6
Total resting periods, locomotor time 10.50.52.61.60.40.0-0.7-0.1-0.40.40.3-0.01.2
Rest time, locomotor task time 10.10.21.1-0.0-0.1-0.40.40.2-0.2-0.51.0-0.00.1
Distance moved, locomotor task time 10.10.40.9-0.30.60.8-0.1-0.40.90.7-0.7-0.5-0.5
Vertical activity count, locomotor time 10.00.10.7-0.10.30.5-0.1-0.30.30.6-0.8-0.1-0.0
Time >=10cm from walls, locomotor time 20.41.16.1-1.1-1.0-0.10.20.2-0.2-2.51.10.2-1.3
Bouts of movement, locomotor time 20.82.54.5-0.20.61.4-1.6-2.11.7-1.6-1.7-1.8-1.9
Total resting periods, locomotor time 20.62.34.40.10.71.6-1.7-2.11.5-1.3-1.7-1.9-1.5
Rest time, locomotor task time 20.20.40.90.30.0-0.30.60.7-0.60.30.90.80.9
Distance moved, locomotor task time 20.10.20.6-0.6-0.5-0.10.20.2-0.1-0.80.10.0-0.4
Vertical activity count, locomotor time 20.10.31.1-0.6-0.9-0.5-0.10.3-0.2-1.0-0.30.4-0.7
Light reinforcement 10.10.50.90.20.40.7-0.8-1.00.6-0.7-0.7-0.9-0.5
Light reinforcement 20.61.45.1-0.6-0.40.5-1.1-1.41.3-0.5-1.2-1.3-2.3
Bone: marrow area0.00.10.20.3-0.10.20.0-0.4-0.0-0.0-0.5-0.30.1
Bone: maximum diameter2.24.47.12.22.62.7-1.7-2.12.01.9-2.5-1.90.5
Bone: maximum force0.10.20.50.60.70.6-0.2-0.50.50.1-0.6-0.40.1
Bone: maximum moment0.20.40.70.70.80.8-0.4-0.60.70.1-0.8-0.60.0
Mean time between licks in bursts0.10.31.3-0.20.80.6-0.1-0.5-0.0-0.2-0.8-0.41.1
Mean num. licks in bursts1.95.09.0-1.8-1.3-2.23.02.9-2.4-0.92.62.71.6
Cd content in liver0.60.62.20.91.30.7-0.2-0.40.21.5-0.3-0.30.9
Co content in liver1.21.42.81.61.31.2-1.1-1.00.71.7-1.3-1.00.4
Cu content in liver0.20.20.70.30.80.30.5-0.0-0.10.00.10.10.8
Fe content in liver0.91.22.9-1.7-1.6-1.20.90.8-0.9-1.10.40.8-0.7
K content in liver2.12.04.70.80.81.8-1.5-1.72.2-0.8-1.0-1.5-1.5
Mg content in liver0.40.51.81.40.50.9-0.8-0.50.8-0.3-0.2-0.2-0.3
Mn content in liver0.40.51.0-0.50.30.8-0.1-0.91.00.6-0.4-0.8-0.8
Na content in liver2.12.34.91.81.51.7-2.2-1.71.50.3-1.4-1.70.1
Rb content in liver0.60.72.11.21.31.4-0.3-0.51.10.4-0.2-0.50.2
Se content in liver1.31.53.00.61.11.5-1.4-1.31.70.4-1.3-1.4-0.8
Sr content in liver3.93.46.32.42.01.9-2.2-1.71.81.0-2.5-1.70.2
Zn content in liver0.70.82.60.00.51.2-0.0-0.81.6-0.6-0.5-0.6-1.4
Bone: minimum diameter0.10.10.4-0.2-0.30.30.60.30.2-0.30.10.3-0.6
Time in familiar zone, hab. session 10.00.00.10.0-0.20.0-0.1-0.3-0.10.30.2-0.3-0.1
Time in novel zone, hab. session 10.10.10.30.10.40.00.20.40.10.3-0.30.40.5
Total zone transitions, hab. session 10.20.21.4-1.20.00.10.6-0.20.2-0.5-0.2-0.0-0.2
Total locomotion distance, hab. session 10.60.82.0-0.80.00.8-0.6-1.21.0-0.2-1.4-1.0-1.1
Locomotion velocity, hab. session 10.30.41.2-0.8-0.20.4-0.3-0.80.6-0.4-1.1-0.7-0.9
Time in familiar zone, hab. session 21.11.22.3-0.5-1.2-1.11.11.3-1.0-0.91.51.4-0.1
Time in novel zone, hab. session 21.01.12.60.41.61.0-0.7-1.10.81.3-1.3-1.10.9
Total zone transitions, hab. session 20.91.22.7-0.80.91.2-0.4-1.41.6-0.3-1.2-1.3-1.0
Total locomotion distance, hab. session 21.01.42.9-0.11.11.4-0.8-1.61.70.0-1.2-1.4-0.9
Locomotion velocity, hab. session 21.62.14.30.01.21.7-1.1-1.92.1-0.0-1.5-1.8-1.3
Novel to familiar place preference ratio0.10.10.7-0.20.50.20.1-0.3-0.2-0.20.2-0.30.8
Novelty place preference0.10.20.8-0.30.50.20.3-0.1-0.3-0.10.3-0.10.9
Time in novel zone, NPP test0.10.21.1-0.20.50.10.40.0-0.40.00.20.11.1
Total zone transitions, NPP test0.50.72.8-1.1-0.7-0.00.2-0.10.7-1.2-0.4-0.1-1.7
Total locomotion distance, NPP test0.60.93.6-0.5-0.40.5-0.7-0.81.2-0.8-0.7-0.8-1.9
Locomotion velocity, NPP test0.81.14.0-0.4-0.20.7-0.9-1.11.4-0.8-0.8-1.0-2.0
Intraocular pressure0.40.62.00.40.90.8-0.7-0.80.31.4-0.8-0.60.5
Delta distance traveled before/after self-admin0.60.73.6-0.5-0.8-0.70.20.4-0.3-1.90.20.3-1.3
Delta ambulatory time before/after self-admin0.40.72.9-0.6-0.8-0.90.20.5-0.3-1.7-0.10.4-1.2
Parametrial fat weight0.81.95.21.82.31.7-0.2-1.11.61.20.2-1.10.9
Pavlov. Cond. lever latency0.20.30.80.90.50.2-0.30.1-0.30.8-0.00.10.9
Pavlov. Cond. magazine entry latency1.01.32.2-1.4-1.5-1.41.21.0-1.2-0.81.01.0-0.2
Pavlov. Cond. change in total contacts1.11.22.20.11.51.3-0.6-1.31.20.9-1.4-1.30.1
Pavlov. Cond. index score0.70.91.9-1.4-1.3-1.00.90.7-0.6-1.00.70.6-0.8
Pavlov. Cond. latency score0.70.82.0-1.4-1.2-0.90.90.6-0.4-1.10.60.6-0.9
Pavlov. Cond. lever contacts0.30.41.3-1.1-0.7-0.40.50.10.1-0.70.30.1-0.9
Pavlov. Cond. magazine entry number1.01.21.91.41.21.3-1.4-1.11.20.5-1.1-1.1-0.1
Pavlov. Cond. intertrial magazine entries1.72.14.30.00.20.8-1.5-2.11.7-0.4-1.6-2.1-2.0
Pavlov. Cond. lever-magazine prob. diff.0.91.12.5-1.6-1.4-1.11.10.8-0.6-1.10.80.7-0.9
Pavlov. Cond. response bias0.20.31.0-1.0-0.7-0.40.60.2-0.2-0.50.30.2-0.6
Pavlov. Cond. lever latency2.73.87.11.61.92.6-2.2-2.02.70.5-1.8-2.0-1.3
Pavlov. Cond. magazine entry latency0.10.10.20.2-0.4-0.3-0.1-0.1-0.5-0.40.2-0.10.2
Pavlov. Cond. change in total contacts0.10.30.7-0.6-0.6-0.80.80.4-0.7-0.10.10.40.3
Pavlov. Cond. index score0.71.12.2-0.8-1.2-1.51.20.9-1.5-0.50.80.90.6
Pavlov. Cond. latency score0.71.12.3-0.8-1.3-1.51.20.9-1.4-0.60.80.90.4
Pavlov. Cond. lever contacts2.74.07.4-1.7-2.1-2.62.22.0-2.7-0.61.92.01.2
Pavlov. Cond. magazine entry number0.50.61.8-0.10.20.7-0.8-0.71.1-0.1-0.9-0.7-1.3
Pavlov. Cond. intertrial magazine entries0.00.10.30.00.30.6-0.1-0.20.5-0.0-0.1-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.91.32.6-0.8-1.3-1.61.31.1-1.6-0.50.81.10.7
Pavlov. Cond. response bias1.82.45.0-1.2-1.4-2.01.81.5-2.2-0.41.41.51.4
Time in closed arm before self-admin0.20.31.3-0.20.50.4-0.3-0.60.5-0.7-1.2-0.6-0.1
Time in closed arm after self-admin1.92.28.4-1.6-1.5-1.41.11.0-0.9-2.91.01.0-1.3
Time in open arm before self-admin0.60.72.0-0.7-1.1-1.40.20.6-1.0-1.00.60.6-0.6
Time in open arm after self-admin0.60.63.30.30.80.70.0-0.40.41.80.3-0.60.9
Bone: periosteal estimation0.41.02.21.00.91.2-0.7-1.11.00.6-1.5-1.0-0.3
Bone: periosteal perimeter1.32.64.21.51.22.1-1.7-1.81.80.4-2.0-1.7-1.0
Bone: post-yield work0.10.10.50.70.10.1-0.6-0.20.1-0.7-0.3-0.30.0
Progressive ratio test 1 active lever presses0.20.40.9-0.30.40.7-0.3-0.80.8-0.6-0.2-0.8-1.0
Progressive ratio test 1 breakpoint0.30.41.0-0.30.50.8-0.4-0.80.8-0.6-0.3-0.8-1.0
Progressive ratio test 1 inactive lever presses1.33.46.70.92.12.3-1.3-2.32.60.8-0.9-2.3-1.6
Progressive ratio test 2 active lever presses0.40.61.20.90.60.7-1.1-0.80.50.8-1.0-0.70.3
Progressive ratio test 2 breakpoint0.40.61.21.00.50.6-1.1-0.70.50.8-1.0-0.70.4
Progressive ratio test 2 inactive lever presses0.31.11.91.11.11.3-0.9-1.31.40.2-0.0-1.2-0.9
Incentive Sensitization - Responses0.41.13.31.80.60.3-1.4-0.60.41.5-1.4-0.50.6
Incentive Sensitization - Breakpoint0.51.13.71.90.50.2-1.4-0.50.21.6-1.3-0.40.8
Sum of active levers in priming session hrs 5-60.60.61.20.70.60.6-1.1-0.50.80.7-1.1-0.6-0.8
Progressive ratio0.20.51.7-1.0-0.60.10.70.50.2-0.80.80.5-1.3
Food seeking constrained by brief footshock2.43.05.81.31.42.2-1.8-1.82.4-0.5-1.0-1.9-2.1
Seeking ratio, punishment vs. effort0.81.83.61.01.41.2-1.6-1.91.40.1-1.6-1.9-0.4
Retroperitoneal fat weight0.41.63.61.91.81.6-0.7-1.31.31.2-0.4-1.10.4
Reaction time number correct0.00.21.20.10.40.10.10.2-0.50.20.30.21.1
Reaction time mean minus median0.42.84.8-0.2-1.5-1.71.61.9-2.2-1.71.92.01.3
Reaction time mean minus median AUC0.32.24.3-0.0-1.3-1.61.11.5-2.1-1.81.71.51.3
Reaction time num false alarms0.91.63.91.31.01.2-2.0-1.31.20.7-1.5-1.2-0.5
Reaction time num false alarms AUC0.81.85.21.50.81.2-2.3-1.21.40.5-1.8-1.2-0.9
Reaction time trials correct on left0.00.21.20.10.40.10.10.2-0.50.20.30.21.1
Reaction time trials on left0.10.21.20.10.30.10.10.2-0.50.10.30.21.1
Reaction time mean0.41.02.1-0.1-1.3-1.10.41.3-0.8-0.91.31.4-0.1
Reaction time mean AUC0.61.42.5-0.2-1.6-1.30.51.4-1.0-1.21.51.6-0.3
Median of all reaction times0.40.61.3-0.3-1.1-0.80.21.0-0.3-0.51.11.1-0.6
Reaction time omissions0.60.92.0-0.3-1.0-1.20.51.3-1.1-0.71.11.40.4
Reaction time false alarm rate1.41.94.81.30.61.1-2.2-1.31.60.3-1.8-1.3-1.3
Reaction time premature initiation rate1.72.65.2-2.3-2.1-1.82.21.1-1.1-1.11.31.2-1.2
Reaction time premature initiations0.51.63.8-1.8-1.5-1.41.91.0-1.2-0.61.11.0-0.3
Std. dev. reaction times0.61.93.40.2-1.4-1.40.91.7-1.7-1.41.81.80.8
Reaction time trials completed0.10.21.20.10.30.10.10.2-0.50.10.30.21.1
Reaction time trials AUC0.00.11.00.10.40.2-0.00.1-0.30.20.20.11.0
Run reversals in cocaine runway, females0.60.74.30.8-0.7-0.2-0.8-0.1-0.3-2.10.3-0.1-0.7
Run reversals in cocaine runway, males0.10.10.20.20.50.30.1-0.30.3-0.2-0.0-0.30.2
Latency to leave start box in cocaine runway0.40.61.40.90.70.6-1.2-0.70.90.6-0.7-0.7-0.4
Latency to leave start box in cocaine runway, F1.62.05.31.71.21.5-2.3-1.31.30.6-1.8-1.3-0.4
Latency to leave start box in cocaine runway, M0.60.61.7-0.9-0.3-1.01.10.5-0.20.41.30.5-0.2
Std. dev. time between licks in bursts0.10.20.5-0.30.20.2-0.3-0.7-0.3-0.6-0.6-0.70.6
Total sessions with >9 infusions1.21.53.7-1.9-1.3-1.41.61.1-1.0-0.91.01.1-0.7
Short access day 1 total inactive lever presses1.01.93.70.61.81.9-0.7-1.81.81.4-0.5-1.6-0.2
Short access day 10 total inactive lever presses0.00.31.5-0.00.40.60.4-0.40.5-0.21.2-0.4-0.5
Short access day 1 total infusions0.81.73.9-2.0-1.0-0.91.80.9-0.6-1.31.51.0-1.2
Short access day 10 total infusions0.30.51.0-1.0-0.9-0.90.40.5-0.6-0.7-0.20.5-0.8
Short access total infusions0.10.21.0-1.0-0.3-0.30.70.2-0.10.2-0.00.2-0.5
Short access day 1 locomotion1.32.16.4-2.5-1.1-1.11.50.8-0.5-2.00.40.8-2.2
Short access day 10 total locomotion1.04.110.7-3.3-1.5-0.72.31.0-0.5-3.31.11.0-2.7
Short access total locomotion2.13.210.3-3.2-1.5-1.22.31.2-1.0-2.11.11.2-1.6
One hour access (0.3 mA shock)0.40.51.00.20.61.0-0.6-0.81.00.1-0.6-0.7-0.6
Compulsive drug intake0.71.02.1-1.1-1.2-1.40.51.3-1.3-0.50.11.2-0.1
One hour access (shock baseline)0.20.51.20.70.71.1-0.4-0.81.00.1-0.2-0.7-0.3
Social response proportion0.50.61.70.11.11.1-0.3-0.81.30.2-0.7-0.9-0.4
Social responses1.11.43.31.01.81.7-0.8-1.21.30.5-0.9-1.20.6
Social time0.10.20.60.60.80.5-0.10.10.5-0.40.40.10.3
Soleus weight0.92.74.61.01.02.0-1.8-1.72.20.4-2.1-1.6-1.6
Bone: stiffness0.10.10.4-0.1-0.2-0.20.70.1-0.4-0.30.40.20.2
Tibialis anterior weight0.93.04.72.22.11.7-1.6-1.41.32.0-2.0-1.60.5
Time to tail flick, vehicle, before self-admin0.50.63.8-0.5-0.00.30.2-0.20.9-1.00.4-0.2-2.0
Time to tail flick, vehicle, after self-admin0.30.63.90.3-0.10.7-0.4-0.20.5-2.00.30.0-1.0
Time to tail flick, test, before self-admin0.40.41.5-0.3-0.4-0.70.50.6-0.80.70.10.41.2
Time to tail flick, test, after self-admin2.12.34.2-0.31.71.7-1.1-2.11.90.5-1.6-1.9-1.0
Delta time to tail flick, vehicle, before/after SA0.30.32.40.4-0.4-0.0-0.40.2-0.3-1.6-0.10.3-0.2
Delta time to tail flick, test, before/after SA1.11.32.60.11.41.6-0.8-1.61.60.1-0.7-1.3-0.9
Tibia length0.20.62.6-0.2-0.70.3-0.7-0.70.7-0.6-0.9-0.6-1.6
Ambulatory time before self-admin0.20.51.00.80.61.0-0.7-0.60.40.9-0.1-0.60.5
Ambulatory time after self-admin0.10.20.9-0.5-0.10.1-0.0-0.10.3-0.6-0.1-0.2-0.9
Bone: tissue strength0.70.82.6-0.10.2-0.51.00.8-1.10.90.70.91.6
Total heroin consumption0.10.20.3-0.6-0.3-0.30.60.5-0.00.4-0.10.4-0.3
Bone: trabecular number0.00.00.0-0.1-0.2-0.20.20.2-0.20.1-0.10.10.1
Bone: trabecular spacing0.71.02.61.30.91.1-1.6-0.90.90.1-0.7-1.10.1
Bone: trabecular thickness0.30.51.2-0.7-1.1-0.80.40.0-0.2-0.9-0.10.2-1.1
Bone: trabecular tissue density0.50.91.4-0.2-0.6-1.01.21.0-1.2-1.11.20.90.8
Water consumed over 24 hours0.30.72.40.51.20.4-0.1-0.4-0.11.4-0.3-0.51.6
Number of responses in last shaping day0.30.31.0-0.9-0.0-0.10.5-0.10.1-0.90.50.0-1.0