Hub : Genes

H2az1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	H2az1	0.04	0.03	1.5e-03	0.01	0.02	0.02	0.01	2.3e-03	5.9e-04	7.0e-04	2.5e-03
2	BLA	alternative polyA	XM_063282425.1	0.07	0.04	3.6e-04	0.05	0.04	0.06	0.04	9.8e-04	3.1e-03	4.9e-04	5.8e-03
3	BLA	alternative polyA	NM_022674.2	0.07	0.04	4.0e-04	0.04	0.04	0.04	0.03	3.9e-03	4.0e-03	2.0e-03	1.2e-02
4	BLA	gene expression	H2az1	0.18	0.09	1.7e-04	0.01	0.04	0.05	0.04	9.1e-02	4.6e-03	1.9e-03	4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.1	1.9	2.3	-1.2	1.5	-1.5	-1.3
Area under the delay curve	0.3	0.3	0.7	-0.6	0.3	-0.3	0.8
BMI with tail	1.2	4.1	6.9	2.6	-2.2	2.1	0.3
BMI without tail	1.3	3.9	7.6	2.8	-2.0	1.9	0.4
Body weight	1.4	6.2	11.9	3.4	-2.5	2.5	-0.8
Weight adjusted by age	0.5	0.8	1.7	0.0	-0.9	0.8	1.3
Bone surface	0.3	0.5	0.7	-0.9	0.7	-0.7	-0.2
Bone volume	0.2	0.3	0.4	-0.7	0.6	-0.6	-0.4
Breakpoint value in progressive ratio session	1.0	1.1	3.1	0.2	0.8	-0.9	-1.8
Number of licking bursts	0.3	0.5	1.3	0.6	-0.3	0.3	-1.1
Context. condit. distance diff. score	0.6	0.7	1.2	-0.6	0.8	-0.8	-1.1
Locomotion velocity, session 1	2.0	2.1	3.3	1.3	-1.8	1.8	-0.4
Locomotion distance, session 1	1.2	1.6	2.7	0.8	-1.6	1.6	-0.6
Locomotion velocity, session 2	0.1	0.1	0.2	-0.2	-0.0	0.0	-0.5
Locomotion distance, session 2	1.4	1.9	3.4	0.8	-1.8	1.8	0.6
Locomotion velocity, session 3	2.4	2.7	4.7	1.2	-2.2	2.1	-0.2
Locomotion distance, session 3	0.2	0.3	0.4	0.2	-0.7	0.6	0.3
Stereotopy head waving bouts, day 3	1.7	2.0	2.7	1.7	-1.6	1.6	0.4
Stereotopy head waving duration, day 3	1.8	2.1	3.3	1.8	-1.6	1.6	-0.2
Locomotion velocity, session 7	0.7	0.7	0.9	0.9	-1.0	0.9	-0.5
Locomotion distance, session 7	0.1	0.1	0.2	-0.0	-0.5	0.4	-0.3
Stereotopy head waving bouts, day 7	1.4	1.6	2.1	0.8	-1.4	1.5	1.3
Stereotopy head waving duration, day 7	2.1	2.5	3.4	0.9	-1.8	1.9	1.6
Locomotion velocity, session 8	0.1	0.1	0.3	-0.0	-0.5	0.5	-0.0
Locomotion distance, session 8	0.5	0.8	1.0	0.5	-1.0	0.9	-1.0
Degree of sensitization distance	0.7	0.7	1.3	-0.5	0.8	-0.9	-1.1
Degree of sensitization stereotypy	0.8	0.9	1.5	0.4	-0.9	1.0	1.2
Conditioned locomotion	0.2	0.2	0.6	-0.8	-0.1	0.0	0.5
Cocaine response after cond. corrected	0.2	0.3	0.8	-0.1	0.5	-0.4	-0.9
Cocaine response after cond. not corrected	0.8	0.9	1.2	-0.7	1.1	-1.1	-1.0
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	0.2	-0.2	0.3
Saline control response	2.9	3.9	6.2	1.0	-2.0	2.0	2.5
Bone: connectivity density	2.1	3.2	4.1	-2.0	1.9	-1.9	-1.3
Bone: cortical apparent density	0.1	0.1	0.5	0.7	0.0	0.0	-0.2
Bone: cortical area	0.5	0.8	2.5	1.6	-0.6	0.6	-0.1
Bone: cortical porosity	0.9	1.0	1.6	0.7	-1.3	1.3	0.2
Bone: cortical porosity	1.3	1.4	2.2	1.1	-1.5	1.5	0.3
Bone: cortical thickness	0.5	0.8	1.9	1.2	-0.0	-0.0	-1.4
Bone: cortical thickness	0.3	0.4	0.9	0.7	0.1	-0.1	-0.9
Bone: cortical tissue density	0.1	0.2	0.6	0.8	-0.0	0.1	-0.2
Condit. Reinf. active minus inactive responses	1.8	2.0	3.3	1.8	-1.5	1.5	0.3
Condit. Reinf. active-inactive response ratio	3.1	3.3	7.6	2.8	-1.6	1.6	-0.3
Condit. Reinf. active responses	0.8	1.0	1.2	0.9	-1.1	1.1	0.8
Condit. Reinf. inactive responses	0.5	0.6	1.3	-1.1	0.2	-0.2	1.0
Incentive salience index mean	0.9	1.1	2.2	1.5	-1.0	1.0	0.1
Condit. Reinf. lever presses	0.1	0.1	0.1	0.4	-0.3	0.3	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.6	0.1	-0.0	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	0.6	0.4	-0.4	-0.9
Condit. Reinf. active responses	0.1	0.2	0.6	0.8	-0.1	0.1	0.3
Condit. Reinf. inactive responses	0.5	0.7	0.8	0.7	-0.9	0.9	0.8
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.6	0.1	-0.1	0.0
Conditioned reinforcement - actives	0.6	1.0	1.4	0.4	-1.2	1.2	1.1
Conditioned reinforcement - inactives	0.3	0.5	1.7	-0.1	-0.3	0.3	1.3
Conditioned locomotion	1.0	1.3	3.8	-1.9	0.7	-0.8	0.5
Patch foraging indifference point 0 sec	0.3	0.5	1.3	-1.1	0.5	-0.6	0.4
Patch foraging indifference point AUC	0.1	0.1	0.4	0.6	-0.1	0.0	-0.1
Delay disc. indifference point, 0s delay	0.9	1.0	1.4	-1.2	0.8	-0.7	1.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.1	-0.4	0.4	0.2
Delay disc. indifference point, 2s delay	1.1	1.2	2.1	-1.4	0.6	-0.6	1.4
Delay disc. indifference point, 24s delay	0.6	0.7	1.5	-1.2	0.7	-0.7	0.5
Delay disc. indifference point, 4s delay	0.5	0.6	0.9	-0.7	0.9	-0.9	0.1
Delay disc. indifference point, 8s delay	0.6	0.7	1.5	0.1	-0.8	0.8	1.2
Indifference point function ln k	0.2	0.4	0.8	0.4	-0.9	0.8	0.0
Indifference point function log k	0.2	0.4	0.8	0.4	-0.9	0.8	0.0
Patch foraging total patch changes 0 sec	0.2	0.4	1.0	-1.0	0.5	-0.5	0.3
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.1	0.4	-0.4	0.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.3	0.5	-0.5	-0.1
Patch foraging total patch changes 24 sec	0.4	0.7	0.9	0.8	-1.0	0.9	0.7
Patch foraging total patch changes 6 sec	0.9	1.3	2.1	-0.7	1.4	-1.4	-0.9
Patch foraging time to switch 0 sec	0.2	0.4	0.5	-0.7	0.7	-0.6	0.4
Patch foraging water rate 0 sec	0.4	0.9	3.5	-0.0	-0.3	0.3	-1.9
Patch foraging water rate 12 sec	1.0	2.0	3.7	1.9	-1.5	1.4	-0.2
Patch foraging water rate 18 sec	0.7	1.0	3.4	0.7	0.3	-0.4	-1.9
Patch foraging water rate 24 sec	0.8	1.1	3.7	0.7	-0.3	0.2	-1.9
Patch foraging water rate 6 sec	2.3	3.3	6.5	2.5	-1.3	1.3	-1.8
Seeking ratio, delayed vs. immediate footshock	2.4	2.9	6.1	-2.5	1.7	-1.7	-0.1
Distance traveled before self-admin	0.3	0.4	0.6	0.2	-0.7	0.7	0.8
Distance traveled after self-admin	0.2	0.3	0.6	0.4	-0.4	0.4	0.8
Extensor digitorum longus weight	3.3	12.9	24.6	5.0	-3.7	3.7	0.1
Bone: elastic displacement	0.3	0.4	0.7	0.8	-0.6	0.5	-0.6
Bone: elastic work	0.8	1.0	2.1	1.3	-0.4	0.4	-1.4
Bone: endosteal estimation	0.4	0.9	2.3	0.7	-0.7	0.7	1.5
Bone: endosteal perimeter	0.8	1.7	1.9	1.1	-1.4	1.4	1.3
Epididymis fat weight	0.8	2.8	3.2	1.8	-1.7	1.7	1.4
Delta time in closed arm before/after self-admin	1.4	1.3	1.6	1.2	-1.2	1.3	0.7
Delta time in open arm before/after self-admin	1.8	1.8	2.6	0.4	-1.5	1.5	1.6
Diff in mean of infusions in LGA sessions	2.5	3.1	4.7	-0.5	2.2	-2.2	-1.7
Delay discount exponential model param	0.3	0.3	0.4	0.7	-0.4	0.4	-0.7
Extinction: sum of active levers before priming	0.6	0.7	2.3	0.2	0.5	-0.5	-1.5
Active lever presses in extinction session 6	1.2	1.2	1.7	-1.1	1.3	-1.3	-0.5
Bone: final force	0.2	0.2	0.8	0.9	-0.3	0.3	-0.2
Bone: final moment	0.1	0.2	0.6	0.8	-0.1	0.1	-0.3
Food consumed during 24 hour testing period	0.6	0.9	1.8	1.3	-0.9	0.9	-0.4
Glucose	0.4	0.6	1.7	1.3	-0.6	0.5	-0.3
Heart weight	0.6	0.9	1.3	1.0	-1.1	1.1	-0.2
Delay discount hyperbolic model param	0.4	0.5	0.8	0.8	-0.5	0.5	-0.9
Intermittent access intake day 1-15 change	0.2	0.5	0.6	-0.5	0.8	-0.7	0.7
Intermittent access intake escalation	0.5	1.1	1.5	-1.1	1.2	-1.2	0.4
Intermittent access intake escalation 2	1.7	1.9	2.8	-1.0	1.7	-1.7	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.3	0.6	-0.4	0.4	0.5
Intermitt. access day 15 inactive lever presses	0.4	0.9	1.6	0.8	-1.3	1.2	0.3
Intermitt. access escalation Index	0.1	0.2	0.4	0.2	-0.6	0.6	0.2
Intermittent access day 1 total infusions	0.9	1.5	3.0	1.7	-1.2	1.2	0.3
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.5	0.1	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.8	0.9	-0.3	0.3	-0.1
Intermittent access total infusions	0.6	0.8	1.9	1.4	-0.8	0.7	-0.0
Intermittent access day 1 locomotion	0.7	0.9	1.3	1.0	-1.1	1.1	0.4
Intermittent access day 15 total locomotion	0.2	0.4	1.0	-0.4	0.4	-0.4	1.0
Intermittent access total locomotion	0.1	0.1	0.1	0.4	-0.2	0.2	0.3
Intermittent access standard deviation	0.1	0.2	0.3	0.6	0.4	-0.4	-0.1
Left kidney weight	0.5	2.3	5.0	2.2	-1.4	1.4	-0.4
Right kidney weight	0.5	2.3	3.3	1.8	-1.7	1.6	-0.6
Cocaine induced anxiety	0.0	0.1	0.1	-0.2	0.3	-0.3	-0.0
Post-drug Anxiety	0.2	0.2	0.4	-0.6	0.3	-0.3	0.6
Baseline Anxiety	0.1	0.1	0.3	0.5	-0.3	0.3	0.1
Tail length	0.1	0.4	0.8	0.9	-0.5	0.5	-0.2
Length with tail	0.3	1.5	2.5	1.6	-1.0	1.0	-1.2
Length without tail	0.1	0.5	0.6	0.8	-0.6	0.6	-0.7
Times rat made contact with spout	2.3	2.6	5.3	-0.5	1.6	-1.6	-2.3
Lifetime Intake	0.8	0.9	1.6	1.3	-1.0	1.0	0.0
Liver weight, left	0.3	0.4	0.6	0.6	-0.8	0.7	0.5
Liver weight, right	0.1	0.2	0.7	0.8	0.0	0.0	-0.0
Locomotor activity	0.0	0.1	0.1	-0.0	0.3	-0.3	0.3
Locomotor testing distance	0.0	0.1	0.1	0.4	-0.1	0.0	0.3
Locomotor testing rearing	0.6	1.2	1.9	0.6	1.1	-1.1	-1.4
Locomotion in novel chamber	6.2	7.9	13.5	-3.7	2.8	-2.8	-1.6
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	-0.4	0.7	-0.7	-0.3
Fecal boli incidents, locomotor time 1	0.6	0.8	1.5	0.2	-0.9	0.9	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.1	0.0	-0.4
Time >=10cm from walls, locomotor time 1	2.8	3.0	4.5	-1.1	2.0	-2.1	-1.4
Bouts of movement, locomotor time 1	0.7	0.8	1.1	-0.5	1.0	-1.0	-1.0
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.2	0.5	-0.5	-0.6
Rest time, locomotor task time 1	0.4	0.5	1.2	0.3	-0.5	0.6	1.1
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.0	0.3	-0.4	-0.4
Vertical activity count, locomotor time 1	0.2	0.5	0.7	-0.7	0.6	-0.6	-0.8
Time >=10cm from walls, locomotor time 2	1.0	1.4	1.9	1.2	-1.4	1.3	0.6
Bouts of movement, locomotor time 2	1.0	1.5	2.1	-1.1	1.5	-1.4	0.9
Total resting periods, locomotor time 2	0.8	1.4	1.8	-1.1	1.4	-1.3	1.0
Rest time, locomotor task time 2	0.3	0.4	0.7	-0.8	0.5	-0.5	0.7
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.3	0.2	-0.2	-0.6
Light reinforcement 1	0.6	1.5	2.2	1.5	-1.5	1.4	0.0
Light reinforcement 2	0.0	0.1	0.1	0.2	-0.4	0.3	0.1
Bone: marrow area	0.4	0.8	2.2	0.6	-0.6	0.6	1.5
Bone: maximum diameter	0.2	0.3	0.5	0.7	-0.5	0.5	0.7
Bone: maximum force	0.1	0.2	0.4	0.7	-0.3	0.3	-0.5
Bone: maximum moment	0.1	0.2	0.4	0.5	-0.1	0.1	-0.7
Mean time between licks in bursts	0.0	0.0	0.1	0.0	0.2	-0.2	-0.3
Mean num. licks in bursts	0.6	0.9	1.4	-0.8	1.2	-1.2	-0.3
Cd content in liver	0.2	0.3	1.0	1.0	0.2	-0.2	-0.1
Co content in liver	4.5	5.2	6.9	2.6	-2.5	2.5	1.1
Cu content in liver	2.8	3.4	4.3	-1.4	2.1	-2.1	-1.7
Fe content in liver	0.4	0.5	1.4	-0.8	0.1	-0.0	1.2
K content in liver	0.8	0.8	1.0	-0.9	1.0	-1.0	0.4
Mg content in liver	0.2	0.2	0.4	-0.4	0.6	-0.6	-0.0
Mn content in liver	0.5	0.6	1.1	0.4	1.0	-1.0	0.4
Na content in liver	0.2	0.3	0.4	-0.7	0.5	-0.6	-0.0
Rb content in liver	0.6	0.7	1.4	0.6	-0.7	0.8	1.2
Se content in liver	0.2	0.2	0.9	-0.1	-0.0	0.0	1.0
Sr content in liver	0.4	0.4	1.5	0.2	0.1	-0.1	1.2
Zn content in liver	22.9	25.4	36.6	-4.8	6.0	-6.0	-2.3
Bone: minimum diameter	1.8	3.2	6.1	2.5	-1.8	1.8	0.7
Time in familiar zone, hab. session 1	0.4	0.4	0.5	-0.3	-0.7	0.7	-0.7
Time in novel zone, hab. session 1	0.6	0.6	2.1	0.1	0.4	-0.3	1.5
Total zone transitions, hab. session 1	2.4	3.3	6.1	1.1	-2.5	2.4	0.2
Total locomotion distance, hab. session 1	0.3	0.5	0.7	-0.0	-0.8	0.8	-0.7
Locomotion velocity, hab. session 1	0.3	0.5	1.3	0.1	-0.6	0.5	-1.1
Time in familiar zone, hab. session 2	0.5	0.5	1.0	0.1	1.0	-1.0	-0.2
Time in novel zone, hab. session 2	0.4	0.4	0.9	-0.2	-0.6	0.6	1.0
Total zone transitions, hab. session 2	1.3	1.7	3.0	0.9	-1.7	1.7	-0.4
Total locomotion distance, hab. session 2	0.2	0.2	0.6	0.4	-0.2	0.2	-0.8
Locomotion velocity, hab. session 2	0.1	0.2	0.6	0.2	-0.2	0.1	-0.8
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.2
Novelty place preference	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.4
Total zone transitions, NPP test	1.3	1.8	2.4	1.5	-1.6	1.5	-0.3
Total locomotion distance, NPP test	0.5	0.6	2.2	0.4	0.3	-0.3	-1.5
Locomotion velocity, NPP test	0.5	0.8	2.6	0.5	0.3	-0.4	-1.6
Intraocular pressure	0.1	0.1	0.4	-0.3	-0.0	0.0	0.6
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.5	0.0	0.0	0.7
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.4	0.4	-0.3	-0.1
Parametrial fat weight	0.1	0.2	0.5	-0.2	0.7	-0.7	-0.1
Pavlov. Cond. lever latency	0.5	0.6	1.0	1.0	-0.8	0.8	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	0.3	-0.8	0.8	0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.4	-0.1	0.2	0.2
Pavlov. Cond. index score	0.2	0.3	0.4	-0.6	0.6	-0.6	0.2
Pavlov. Cond. latency score	0.4	0.5	0.6	-0.8	0.8	-0.7	0.3
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.6	0.7	-0.7	0.1
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	-0.8	0.9	-0.9	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.2	0.5	-0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.6	0.8	-0.8	0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.1	-0.5	0.5	0.2
Pavlov. Cond. lever latency	0.6	0.8	1.6	-1.3	0.7	-0.7	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.2	-0.1	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4
Pavlov. Cond. index score	0.1	0.1	0.3	-0.0	0.3	-0.3	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.3	0.6	-0.5	-0.5
Pavlov. Cond. lever contacts	0.6	0.8	1.9	1.4	-0.7	0.7	-0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.2	0.2	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.1	0.4	-0.4	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	0.4	-0.4	-0.5
Pavlov. Cond. response bias	0.8	1.2	2.2	1.5	-1.1	1.1	-0.0
Time in closed arm before self-admin	0.6	0.7	1.5	-0.5	0.7	-0.7	-1.2
Time in closed arm after self-admin	1.3	1.4	2.8	-0.7	1.0	-1.0	-1.7
Time in open arm before self-admin	0.3	0.3	0.7	0.4	0.4	-0.5	-0.8
Time in open arm after self-admin	1.1	1.2	1.6	0.4	-1.2	1.3	1.2
Bone: periosteal estimation	0.6	1.2	2.4	1.6	-0.9	0.9	0.9
Bone: periosteal perimeter	1.3	2.3	2.8	1.7	-1.5	1.5	1.3
Bone: post-yield work	0.3	0.4	1.6	-1.3	-0.1	0.1	0.2
Progressive ratio test 1 active lever presses	2.5	3.1	5.5	2.3	-1.8	1.8	0.9
Progressive ratio test 1 breakpoint	2.1	2.6	5.0	2.2	-1.6	1.6	0.7
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.3	0.5	-0.5	0.5	0.6
Progressive ratio test 2 active lever presses	1.4	1.6	4.3	2.1	-1.0	1.0	0.3
Progressive ratio test 2 breakpoint	1.1	1.2	3.5	1.9	-0.8	0.9	0.1
Progressive ratio test 2 inactive lever presses	0.5	0.8	0.9	0.9	-1.0	1.0	0.7
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.4	-0.3	0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.5	-0.4	0.0
Sum of active levers in priming session hrs 5-6	5.1	4.7	6.6	-1.1	2.6	-2.6	-2.2
Progressive ratio	0.2	0.3	0.5	-0.0	-0.7	0.7	0.5
Food seeking constrained by brief footshock	0.7	0.8	2.1	1.5	0.2	-0.2	-1.0
Seeking ratio, punishment vs. effort	0.7	1.1	1.8	0.5	1.0	-1.0	-1.3
Retroperitoneal fat weight	0.1	0.5	1.6	1.2	-0.5	0.5	0.2
Reaction time number correct	0.0	0.1	0.3	0.2	-0.0	-0.0	-0.5
Reaction time mean minus median	0.1	0.3	0.5	-0.5	0.7	-0.6	0.4
Reaction time mean minus median AUC	0.2	0.5	0.8	-0.5	0.9	-0.8	0.2
Reaction time num false alarms	1.8	2.5	3.6	-0.1	-1.8	1.8	1.9
Reaction time num false alarms AUC	2.1	3.3	4.8	0.3	-2.2	2.2	1.9
Reaction time trials correct on left	0.0	0.1	0.3	0.2	-0.0	-0.0	-0.5
Reaction time trials on left	0.0	0.1	0.3	0.1	0.1	-0.1	-0.5
Reaction time mean	0.1	0.1	0.2	-0.3	0.5	-0.4	0.1
Reaction time mean AUC	0.0	0.1	0.1	-0.0	0.3	-0.2	0.3
Median of all reaction times	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.1
Reaction time omissions	1.0	1.4	2.5	-1.6	1.3	-1.2	0.4
Reaction time false alarm rate	1.3	1.8	2.5	-0.1	-1.5	1.5	1.6
Reaction time premature initiation rate	2.5	3.4	5.1	1.7	-2.3	2.2	0.9
Reaction time premature initiations	2.2	3.9	5.8	1.9	-2.4	2.4	0.8
Std. dev. reaction times	0.4	0.7	1.1	-0.9	1.0	-0.9	0.3
Reaction time trials completed	0.0	0.1	0.3	0.1	0.1	-0.1	-0.5
Reaction time trials AUC	0.0	0.1	0.3	0.3	-0.1	0.0	-0.5
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.1	0.7	-0.7	-0.2
Run reversals in cocaine runway, males	0.3	0.3	0.4	0.6	0.5	-0.5	-0.7
Latency to leave start box in cocaine runway	0.2	0.3	0.5	-0.7	0.5	-0.6	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	0.1	-0.2	0.2	0.7
Latency to leave start box in cocaine runway, M	2.0	1.9	2.2	-1.5	1.4	-1.5	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.4
Total sessions with >9 infusions	1.5	1.8	2.4	1.0	-1.5	1.5	1.2
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.3	-0.6	0.5	-0.5
Short access day 10 total inactive lever presses	0.3	0.8	3.0	-1.7	0.3	-0.3	0.5
Short access day 1 total infusions	0.9	1.3	2.1	0.4	-1.4	1.4	0.9
Short access day 10 total infusions	0.6	0.7	1.0	1.0	-0.9	0.8	0.7
Short access total infusions	1.0	1.2	1.9	0.9	-1.4	1.3	0.6
Short access day 1 locomotion	0.3	0.4	0.9	0.3	-0.9	0.9	0.1
Short access day 10 total locomotion	0.1	0.2	0.3	-0.2	0.5	-0.6	0.0
Short access total locomotion	0.2	0.2	0.6	-0.4	-0.1	0.1	0.8
One hour access (0.3 mA shock)	0.2	0.2	0.2	0.5	0.5	-0.5	0.1
Compulsive drug intake	0.2	0.3	0.6	-0.2	0.7	-0.7	-0.1
One hour access (shock baseline)	0.1	0.2	0.6	0.8	-0.2	0.2	0.2
Social response proportion	0.3	0.4	1.2	-1.1	0.2	-0.2	0.4
Social responses	1.0	1.3	2.4	-0.8	1.0	-1.0	-1.5
Social time	1.2	1.7	3.5	-1.9	1.2	-1.2	-0.6
Soleus weight	1.0	2.9	4.0	2.0	-1.8	1.8	0.9
Bone: stiffness	0.2	0.3	0.5	0.7	-0.4	0.4	-0.6
Tibialis anterior weight	3.5	11.9	23.9	4.9	-3.4	3.4	-0.3
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.0	-0.7	-0.4	0.5	1.0
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.5	-0.7	-0.4	0.4	1.6
Time to tail flick, test, before self-admin	0.5	0.5	0.9	-0.9	0.5	-0.4	0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.3	-0.6	0.5	0.8
Delta time to tail flick, test, before/after SA	0.6	0.6	0.9	1.0	-0.7	0.7	-0.7
Tibia length	0.3	0.9	2.8	1.7	-0.5	0.6	0.5
Ambulatory time before self-admin	0.4	0.6	0.9	0.1	-1.0	0.9	0.8
Ambulatory time after self-admin	0.5	0.6	1.6	0.0	-0.6	0.6	1.3
Bone: tissue strength	0.3	0.3	1.1	0.4	-0.1	0.1	-1.1
Total heroin consumption	0.6	0.7	0.9	-0.4	0.9	-0.9	-0.9
Bone: trabecular number	0.3	0.5	1.5	-1.2	0.5	-0.5	0.4
Bone: trabecular spacing	0.8	1.0	1.7	0.0	1.3	-1.3	-0.9
Bone: trabecular thickness	0.3	0.4	0.7	0.1	-0.9	0.9	0.0
Bone: trabecular tissue density	0.2	0.3	0.5	0.5	-0.7	0.7	0.3
Water consumed over 24 hours	0.3	0.5	1.5	0.5	0.1	-0.1	-1.2
Number of responses in last shaping day	5.3	5.8	7.5	1.6	-2.7	2.7	2.4