Hub : Genes

H1f0

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression H1f0 0.03 0.02 7.1e-04 0.03 0.02 0.02 0.02 7.1e-05 2.2e-04 4.3e-04 3.2e-04
2 Liver gene expression H1f0 0.25 0.1 0.0e+00 0.2 0.16 0.21 0.21 4.4e-22 8.2e-18 1.2e-22 1.1e-22
3 Brain gene expression H1f0 0.1 0.05 9.8e-08 0.04 0.08 0.09 0.08 8.0e-05 5.8e-08 2.3e-08 8.2e-08
4 PL gene expression H1f0 0.03 0.02 7.3e-03 0 0.01 0.01 0.01 9.3e-02 1.7e-02 1.4e-02 3.3e-02
5 Adipose gene expression H1f0 0.09 0.05 3.8e-09 0.02 0.06 0.05 0.05 5.3e-03 5.7e-07 2.1e-06 1.6e-06
6 OFC gene expression H1f0 0.25 0.12 7.9e-04 0 0.14 0.12 0.1 2.8e-01 2.8e-04 9.1e-04 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.00.0-0.2-0.1-0.1-0.10.10.1
Area under the delay curve2.42.83.4-1.61.51.81.6-1.81.8
BMI with tail0.30.92.00.9-0.9-1.4-0.41.2-0.4
BMI without tail0.82.44.21.0-1.1-2.1-1.12.0-1.7
Body weight1.77.512.32.6-2.5-3.5-2.43.0-2.3
Weight adjusted by age0.61.01.51.1-1.0-0.9-1.20.9-0.7
Bone surface0.10.20.5-0.0-0.10.70.3-0.60.5
Bone volume0.00.10.1-0.30.10.30.3-0.20.1
Breakpoint value in progressive ratio session0.20.20.4-0.40.30.40.5-0.50.6
Number of licking bursts0.50.81.4-0.90.91.21.2-0.2-0.3
Context. condit. distance diff. score3.13.86.81.8-1.7-2.6-2.31.5-1.4
Locomotion velocity, session 10.70.71.81.3-1.30.1-1.00.0-0.1
Locomotion distance, session 13.13.98.7-1.51.42.91.9-2.21.5
Locomotion velocity, session 21.01.22.70.4-0.51.40.6-1.41.6
Locomotion distance, session 23.75.29.4-1.91.83.12.3-2.51.9
Locomotion velocity, session 30.50.61.10.9-0.9-0.2-1.10.2-0.9
Locomotion distance, session 30.80.91.4-1.21.11.20.9-0.6-0.5
Stereotopy head waving bouts, day 30.70.91.41.2-1.0-1.1-1.00.7-0.2
Stereotopy head waving duration, day 33.44.06.72.6-2.4-2.1-2.31.4-0.5
Locomotion velocity, session 71.21.41.61.2-1.2-1.0-1.31.3-1.1
Locomotion distance, session 71.41.82.70.9-1.1-1.3-1.61.5-1.5
Stereotopy head waving bouts, day 72.42.75.42.3-2.3-1.1-2.00.7-0.2
Stereotopy head waving duration, day 71.72.04.32.1-2.0-1.0-1.60.30.3
Locomotion velocity, session 81.51.83.81.9-1.8-1.1-1.70.2-0.0
Locomotion distance, session 80.20.40.80.7-0.7-0.5-0.9-0.10.1
Degree of sensitization distance5.96.08.92.4-2.5-3.0-2.92.3-1.2
Degree of sensitization stereotypy1.71.84.42.1-2.0-0.3-1.50.00.4
Conditioned locomotion1.21.32.11.4-1.3-1.0-0.91.3-1.0
Cocaine response after cond. corrected0.20.30.90.9-0.60.3-0.0-0.10.7
Cocaine response after cond. not corrected0.30.30.90.5-0.20.50.4-0.41.0
Cocaine response before conditioning0.60.81.4-1.21.10.61.0-0.60.3
Saline control response0.00.00.20.10.0-0.2-0.10.0-0.4
Bone: connectivity density0.20.40.50.6-0.7-0.5-0.70.6-0.6
Bone: cortical apparent density0.50.72.4-0.70.70.00.50.8-1.5
Bone: cortical area0.20.41.40.8-1.20.0-0.30.30.2
Bone: cortical porosity0.30.31.20.5-0.40.00.1-0.51.1
Bone: cortical porosity0.70.81.71.3-1.2-0.2-0.5-0.41.1
Bone: cortical thickness0.81.42.6-1.31.01.31.6-0.80.7
Bone: cortical thickness1.72.03.7-1.41.41.41.9-1.10.9
Bone: cortical tissue density0.50.72.5-0.60.6-0.00.40.9-1.6
Condit. Reinf. active minus inactive responses0.30.41.1-0.50.50.20.50.5-1.0
Condit. Reinf. active-inactive response ratio0.30.31.40.00.1-0.20.00.6-1.2
Condit. Reinf. active responses0.60.81.7-1.11.0-0.00.60.7-1.3
Condit. Reinf. inactive responses0.70.81.9-1.41.2-0.30.30.7-1.0
Incentive salience index mean0.60.72.4-0.50.4-0.20.31.1-1.6
Condit. Reinf. lever presses0.71.03.2-0.50.3-0.70.01.5-1.8
Condit. Reinf. active minus inactive responses0.20.30.7-0.20.4-0.2-0.1-0.80.8
Condit. Reinf. active-inactive response ratio0.10.20.20.4-0.3-0.5-0.5-0.20.4
Condit. Reinf. active responses0.40.51.6-0.10.20.1-0.2-1.21.2
Condit. Reinf. inactive responses0.40.61.2-0.40.41.00.4-1.10.8
Condit. Reinf. lever presses0.20.20.5-0.70.7-0.30.1-0.40.3
Condit. Reinf. lever reinforcers received0.30.41.10.1-0.1-0.2-0.5-0.91.1
Conditioned reinforcement - actives2.74.55.5-2.02.42.32.4-2.21.5
Conditioned reinforcement - inactives2.43.55.8-2.42.41.52.3-1.30.8
Conditioned locomotion2.53.24.5-1.61.51.61.8-2.12.1
Patch foraging indifference point 0 sec0.50.92.30.4-0.6-0.9-0.61.2-1.5
Patch foraging indifference point AUC0.60.81.3-1.01.11.21.0-0.6-0.3
Delay disc. indifference point, 0s delay0.20.31.0-0.50.10.10.4-0.31.0
Delay disc. indifference point, 16s delay2.62.93.8-1.51.62.01.6-1.81.7
Delay disc. indifference point, 2s delay9.610.715.2-2.82.43.63.0-3.73.9
Delay disc. indifference point, 24s delay0.40.41.10.6-0.40.70.00.4-1.0
Delay disc. indifference point, 4s delay1.61.63.4-1.00.81.20.9-1.51.9
Delay disc. indifference point, 8s delay0.81.01.9-1.41.30.91.0-0.60.3
Indifference point function ln k0.71.22.11.4-1.3-1.1-1.10.8-0.3
Indifference point function log k0.71.22.11.4-1.3-1.1-1.10.8-0.3
Patch foraging total patch changes 0 sec0.20.41.4-0.10.0-0.4-0.00.7-1.2
Patch foraging total patch changes 12 sec0.10.10.40.0-0.10.60.2-0.3-0.2
Patch foraging total patch changes 18 sec0.10.10.5-0.20.20.20.30.3-0.7
Patch foraging total patch changes 24 sec0.30.61.2-1.10.70.40.60.3-1.1
Patch foraging total patch changes 6 sec0.10.10.3-0.50.40.10.30.1-0.6
Patch foraging time to switch 0 sec0.40.83.60.4-0.4-0.2-0.4-0.81.9
Patch foraging water rate 0 sec1.32.88.10.8-0.6-1.4-0.72.3-2.9
Patch foraging water rate 12 sec0.20.51.80.0-0.1-0.00.41.0-1.4
Patch foraging water rate 18 sec1.21.95.91.0-0.7-0.7-0.61.8-2.4
Patch foraging water rate 24 sec2.23.13.91.9-1.6-1.7-1.42.0-2.0
Patch foraging water rate 6 sec0.91.34.8-0.30.3-0.40.41.6-2.2
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.2-0.10.2-0.3-0.40.5
Distance traveled before self-admin0.81.02.9-0.70.60.70.5-1.21.7
Distance traveled after self-admin0.60.80.90.8-0.8-0.9-0.81.0-0.9
Extensor digitorum longus weight0.83.04.2-1.91.81.11.9-1.52.1
Bone: elastic displacement1.01.21.81.3-1.3-1.0-1.30.9-0.4
Bone: elastic work2.33.06.62.4-2.6-1.1-1.80.90.2
Bone: endosteal estimation1.12.55.22.2-2.3-1.0-1.80.7-0.1
Bone: endosteal perimeter1.32.86.52.5-2.6-0.9-1.70.70.1
Epididymis fat weight0.93.25.71.9-2.0-2.4-1.71.5-1.1
Delta time in closed arm before/after self-admin1.91.83.0-1.31.61.11.7-1.20.9
Delta time in open arm before/after self-admin0.10.10.40.5-0.40.0-0.6-0.00.2
Diff in mean of infusions in LGA sessions0.30.40.80.7-0.5-0.4-0.50.7-0.9
Delay discount exponential model param2.52.83.61.6-1.5-1.9-1.61.7-1.7
Extinction: sum of active levers before priming1.31.53.0-0.30.41.60.8-1.61.7
Active lever presses in extinction session 60.10.10.30.3-0.20.40.1-0.40.6
Bone: final force0.50.82.31.3-1.50.0-0.60.10.6
Bone: final moment0.61.02.91.5-1.7-0.2-0.80.30.4
Food consumed during 24 hour testing period0.20.20.5-0.0-0.00.60.4-0.70.7
Glucose0.30.51.1-0.30.3-0.80.41.1-0.9
Heart weight4.26.410.83.3-3.1-2.2-2.52.2-1.5
Delay discount hyperbolic model param3.64.04.81.9-1.7-2.2-1.92.1-2.1
Intermittent access intake day 1-15 change0.20.30.6-0.80.60.50.7-0.50.1
Intermittent access intake escalation0.10.30.6-0.80.70.50.6-0.4-0.0
Intermittent access intake escalation 20.20.20.4-0.60.6-0.00.40.2-0.5
Intermitt. access day 1 inactive lever presses0.51.82.51.2-1.0-1.6-1.41.6-1.3
Intermitt. access day 15 inactive lever presses0.10.20.40.00.1-0.4-0.30.5-0.6
Intermitt. access escalation Index1.11.52.4-1.31.41.31.6-0.90.5
Intermittent access day 1 total infusions2.43.85.9-1.31.62.31.9-2.42.0
Intermittent access day 15 total infusions2.13.24.4-1.61.62.11.7-2.11.5
Intermittent access terminal intake (last 3 days)1.92.53.9-1.21.32.01.4-1.91.4
Intermittent access total infusions3.74.46.5-1.61.72.41.9-2.52.2
Intermittent access day 1 locomotion1.01.31.5-1.11.11.21.2-1.21.0
Intermittent access day 15 total locomotion0.40.71.0-0.90.80.81.0-0.80.6
Intermittent access total locomotion0.30.40.8-0.80.70.30.9-0.40.3
Intermittent access standard deviation0.00.10.4-0.0-0.3-0.1-0.0-0.20.6
Left kidney weight3.616.531.95.6-5.5-3.4-4.62.0-0.7
Right kidney weight4.822.036.76.1-6.0-4.5-5.23.1-1.6
Cocaine induced anxiety0.20.20.70.2-0.8-0.4-0.6-0.00.4
Post-drug Anxiety1.51.62.60.8-1.3-1.6-1.31.4-0.9
Baseline Anxiety0.10.10.40.00.2-0.10.10.6-0.6
Tail length0.93.46.60.7-0.7-2.4-1.42.3-2.6
Length with tail1.67.010.12.4-2.2-3.2-2.62.8-2.7
Length without tail1.96.09.23.0-3.0-2.4-2.61.9-1.3
Times rat made contact with spout1.11.34.1-0.91.00.41.00.8-2.0
Lifetime Intake3.74.56.6-1.61.62.42.0-2.62.3
Liver weight, left0.00.00.2-0.10.2-0.00.2-0.40.1
Liver weight, right0.91.62.41.2-1.0-1.5-0.91.2-1.6
Locomotor activity0.30.41.11.0-1.0-0.4-0.40.4-0.3
Locomotor testing distance0.30.51.6-0.60.70.81.3-0.0-0.3
Locomotor testing rearing0.10.20.50.4-0.20.70.7-0.30.2
Locomotion in novel chamber1.31.74.4-1.72.10.51.5-0.50.1
Locomotion in novel chamber post-restriction2.23.65.2-2.12.31.82.3-1.61.2
Fecal boli incidents, locomotor time 10.30.41.00.7-0.4-0.3-0.30.9-1.0
Change in fecal boli incidents, locomotor task0.40.41.00.7-0.7-0.4-0.50.5-1.0
Time >=10cm from walls, locomotor time 10.40.41.21.1-0.9-0.3-0.50.4-0.1
Bouts of movement, locomotor time 10.10.10.20.2-0.3-0.1-0.00.3-0.4
Total resting periods, locomotor time 10.20.20.30.4-0.5-0.4-0.30.5-0.4
Rest time, locomotor task time 10.91.11.60.8-0.8-1.2-1.11.2-1.1
Distance moved, locomotor task time 10.00.10.10.2-0.10.30.2-0.30.2
Vertical activity count, locomotor time 10.41.12.50.1-0.2-1.2-0.31.5-1.6
Time >=10cm from walls, locomotor time 21.82.74.31.9-1.6-1.0-1.12.1-1.9
Bouts of movement, locomotor time 22.74.47.0-2.01.81.92.6-2.02.1
Total resting periods, locomotor time 22.85.06.7-2.11.82.02.6-2.32.4
Rest time, locomotor task time 20.10.10.3-0.3-0.0-0.5-0.30.00.1
Distance moved, locomotor task time 20.91.01.71.3-1.1-0.4-0.91.1-1.0
Vertical activity count, locomotor time 21.11.53.60.8-0.8-0.8-0.41.9-1.8
Light reinforcement 10.00.10.30.3-0.30.5-0.1-0.20.3
Light reinforcement 20.30.41.00.00.00.80.6-0.71.0
Bone: marrow area1.22.75.62.3-2.4-1.0-1.90.7-0.1
Bone: maximum diameter1.42.76.82.3-2.6-0.9-1.60.80.1
Bone: maximum force0.50.82.41.4-1.60.1-0.50.10.6
Bone: maximum moment0.61.13.11.6-1.8-0.1-0.80.20.5
Mean time between licks in bursts0.30.82.90.10.10.80.4-1.01.7
Mean num. licks in bursts0.20.41.20.2-0.1-0.7-0.40.6-1.1
Cd content in liver0.70.71.9-0.30.31.41.1-0.90.5
Co content in liver0.80.92.2-0.71.11.01.5-0.40.4
Cu content in liver1.72.05.1-1.92.30.81.6-0.4-0.0
Fe content in liver4.04.97.82.8-2.8-2.2-2.71.4-0.5
K content in liver0.10.10.4-0.10.6-0.50.00.2-0.4
Mg content in liver0.10.10.3-0.00.5-0.20.20.3-0.5
Mn content in liver0.60.71.4-0.91.20.70.9-0.80.4
Na content in liver0.50.51.10.2-0.0-1.0-0.50.9-0.9
Rb content in liver0.00.00.10.2-0.2-0.2-0.30.2-0.1
Se content in liver0.70.91.5-0.81.00.91.2-0.90.5
Sr content in liver2.62.35.1-2.32.21.01.5-0.70.3
Zn content in liver0.30.40.9-0.50.90.40.9-0.2-0.4
Bone: minimum diameter0.10.20.50.6-0.70.1-0.3-0.20.4
Time in familiar zone, hab. session 10.50.51.10.8-1.0-0.4-0.90.5-0.3
Time in novel zone, hab. session 10.00.00.10.3-0.1-0.10.1-0.10.2
Total zone transitions, hab. session 11.62.33.5-1.91.81.61.4-1.40.5
Total locomotion distance, hab. session 10.71.01.6-1.31.21.01.1-0.8-0.0
Locomotion velocity, hab. session 10.91.22.1-1.41.41.11.2-0.8-0.0
Time in familiar zone, hab. session 20.10.10.3-0.20.20.50.50.1-0.4
Time in novel zone, hab. session 20.20.20.4-0.50.6-0.00.3-0.50.6
Total zone transitions, hab. session 20.30.40.7-0.70.80.90.7-0.3-0.4
Total locomotion distance, hab. session 20.20.30.5-0.40.50.60.4-0.70.5
Locomotion velocity, hab. session 20.10.10.2-0.40.50.30.2-0.40.2
Novel to familiar place preference ratio0.40.40.90.9-0.9-0.4-0.70.1-0.2
Novelty place preference0.30.30.80.9-0.9-0.3-0.50.1-0.4
Time in novel zone, NPP test0.30.40.80.9-0.9-0.4-0.60.2-0.4
Total zone transitions, NPP test1.21.72.6-1.61.61.61.3-1.10.2
Total locomotion distance, NPP test0.10.20.7-0.20.30.80.2-0.50.1
Locomotion velocity, NPP test0.30.41.1-0.60.61.10.5-0.70.2
Intraocular pressure0.20.30.80.9-0.9-0.1-0.5-0.20.2
Delta distance traveled before/after self-admin3.63.87.01.6-1.8-1.7-1.72.1-2.6
Delta ambulatory time before/after self-admin2.93.55.71.9-2.0-1.3-1.71.9-2.4
Parametrial fat weight1.12.55.20.6-0.5-1.9-0.82.3-2.2
Pavlov. Cond. lever latency0.00.00.00.20.2-0.20.0-0.20.2
Pavlov. Cond. magazine entry latency0.60.81.4-0.80.41.10.9-0.91.2
Pavlov. Cond. change in total contacts1.31.42.5-1.21.01.61.2-1.11.0
Pavlov. Cond. index score0.10.10.3-0.4-0.10.60.3-0.10.2
Pavlov. Cond. latency score0.00.10.2-0.3-0.10.40.2-0.00.2
Pavlov. Cond. lever contacts0.10.10.2-0.50.10.20.10.3-0.3
Pavlov. Cond. magazine entry number0.60.81.31.0-0.6-1.1-0.90.7-0.7
Pavlov. Cond. intertrial magazine entries0.50.62.3-0.10.2-0.6-0.31.0-1.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.50.10.70.4-0.20.3
Pavlov. Cond. response bias0.20.20.5-0.70.20.70.5-0.20.3
Pavlov. Cond. lever latency0.71.02.0-0.60.61.41.2-1.10.6
Pavlov. Cond. magazine entry latency0.20.30.8-0.90.8-0.10.4-0.00.0
Pavlov. Cond. change in total contacts3.14.97.02.3-2.3-2.7-2.62.1-1.1
Pavlov. Cond. index score0.60.81.70.3-0.4-1.3-1.01.0-0.7
Pavlov. Cond. latency score0.60.81.80.3-0.3-1.3-1.01.2-0.9
Pavlov. Cond. lever contacts0.71.02.10.6-0.6-1.5-1.11.1-0.8
Pavlov. Cond. magazine entry number0.50.61.6-0.20.21.30.9-0.80.6
Pavlov. Cond. intertrial magazine entries0.10.20.40.1-0.1-0.5-0.40.5-0.6
Pavlov. Cond. lever-magazine prob. diff.0.50.71.80.3-0.4-1.3-1.00.9-0.5
Pavlov. Cond. response bias0.50.61.60.5-0.5-1.2-1.10.8-0.3
Time in closed arm before self-admin0.10.20.3-0.50.2-0.5-0.10.6-0.1
Time in closed arm after self-admin0.40.40.6-0.50.7-0.70.50.6-0.8
Time in open arm before self-admin0.30.31.00.3-0.4-0.4-0.50.6-1.0
Time in open arm after self-admin0.00.00.10.1-0.10.3-0.2-0.0-0.1
Bone: periosteal estimation0.91.84.81.9-2.2-0.6-1.30.50.2
Bone: periosteal perimeter2.03.58.62.7-2.9-0.9-1.71.0-0.3
Bone: post-yield work0.20.41.20.3-0.31.10.4-0.50.5
Progressive ratio test 1 active lever presses2.42.94.6-1.21.32.01.5-2.11.9
Progressive ratio test 1 breakpoint2.12.64.1-1.21.21.91.4-2.01.8
Progressive ratio test 1 inactive lever presses1.31.93.9-1.31.30.91.0-1.52.0
Progressive ratio test 2 active lever presses3.33.94.5-2.02.12.12.1-2.01.4
Progressive ratio test 2 breakpoint3.84.45.1-2.02.22.32.2-2.21.7
Progressive ratio test 2 inactive lever presses2.33.85.5-2.32.32.02.1-1.60.9
Incentive Sensitization - Responses1.01.42.5-1.41.61.11.4-0.90.4
Incentive Sensitization - Breakpoint1.11.52.7-1.41.61.11.4-0.90.4
Sum of active levers in priming session hrs 5-60.00.00.10.20.1-0.30.10.10.1
Progressive ratio0.00.10.10.1-0.2-0.2-0.4-0.20.4
Food seeking constrained by brief footshock0.91.12.2-0.20.31.51.3-1.11.1
Seeking ratio, punishment vs. effort0.10.20.6-0.00.20.70.8-0.20.2
Retroperitoneal fat weight1.45.910.53.2-3.0-2.4-2.22.1-0.9
Reaction time number correct0.51.01.9-1.00.91.41.1-0.90.1
Reaction time mean minus median0.00.10.30.2-0.1-0.5-0.60.10.1
Reaction time mean minus median AUC0.10.20.70.3-0.2-0.8-0.60.3-0.1
Reaction time num false alarms0.10.20.6-0.20.30.50.8-0.2-0.1
Reaction time num false alarms AUC0.20.30.8-0.30.40.60.9-0.4-0.0
Reaction time trials correct on left0.51.01.9-1.00.91.41.1-0.90.1
Reaction time trials on left0.71.22.3-1.21.11.51.2-1.10.2
Reaction time mean0.60.92.00.8-0.7-1.4-1.20.9-0.4
Reaction time mean AUC0.30.51.30.5-0.4-1.1-1.00.6-0.2
Median of all reaction times0.60.81.70.8-0.7-1.3-1.10.9-0.3
Reaction time omissions3.14.56.6-1.61.72.22.1-2.52.6
Reaction time false alarm rate0.00.00.20.10.1-0.00.40.00.0
Reaction time premature initiation rate0.10.10.50.4-0.70.0-0.10.20.1
Reaction time premature initiations0.00.10.3-0.1-0.10.50.4-0.1-0.0
Std. dev. reaction times0.20.51.00.5-0.5-1.0-0.90.5-0.3
Reaction time trials completed0.71.22.3-1.21.11.51.2-1.10.2
Reaction time trials AUC0.50.91.9-1.00.81.41.0-1.00.1
Run reversals in cocaine runway, females1.01.01.30.6-0.8-1.1-1.11.1-1.1
Run reversals in cocaine runway, males0.20.20.30.60.00.6-0.1-0.4-0.4
Latency to leave start box in cocaine runway0.50.61.60.9-0.7-0.0-0.6-0.61.3
Latency to leave start box in cocaine runway, F0.50.61.30.9-0.90.2-0.6-0.41.1
Latency to leave start box in cocaine runway, M0.10.10.30.20.2-0.4-0.2-0.40.5
Std. dev. time between licks in bursts0.30.40.60.8-0.6-0.7-0.80.5-0.4
Total sessions with >9 infusions0.81.02.4-0.00.01.10.4-1.41.5
Short access day 1 total inactive lever presses1.01.42.61.3-1.3-1.3-1.60.8-0.4
Short access day 10 total inactive lever presses2.45.79.31.8-1.8-2.4-2.22.9-3.1
Short access day 1 total infusions0.10.10.20.5-0.4-0.1-0.40.1-0.1
Short access day 10 total infusions0.91.22.6-0.30.11.30.5-1.61.6
Short access total infusions1.31.63.0-0.50.51.50.9-1.71.7
Short access day 1 locomotion0.00.10.10.2-0.1-0.4-0.30.1-0.2
Short access day 10 total locomotion0.30.51.0-0.50.3-0.90.11.0-0.9
Short access total locomotion0.10.10.2-0.40.2-0.10.2-0.20.4
One hour access (0.3 mA shock)8.49.711.7-3.23.33.43.4-3.12.2
Compulsive drug intake0.40.51.0-0.91.00.10.50.3-0.8
One hour access (shock baseline)2.84.25.8-1.71.82.12.0-2.42.2
Social response proportion1.31.56.10.6-0.80.4-0.3-1.22.5
Social responses0.70.91.9-0.30.11.20.6-1.21.4
Social time1.42.02.8-1.31.41.61.7-1.11.2
Soleus weight0.51.43.5-1.00.8-0.60.71.5-1.9
Bone: stiffness0.61.02.31.4-1.5-0.5-0.70.8-0.1
Tibialis anterior weight2.48.312.8-3.63.52.23.2-2.32.1
Time to tail flick, vehicle, before self-admin0.30.30.5-0.60.60.30.5-0.60.7
Time to tail flick, vehicle, after self-admin1.11.43.50.6-0.0-1.4-0.51.6-1.9
Time to tail flick, test, before self-admin2.02.02.5-1.61.41.41.4-1.61.1
Time to tail flick, test, after self-admin0.20.20.90.00.1-0.20.10.7-0.9
Delta time to tail flick, vehicle, before/after SA0.70.61.01.0-0.7-0.7-0.90.8-0.8
Delta time to tail flick, test, before/after SA0.50.51.3-0.00.2-0.70.11.1-1.1
Tibia length0.41.12.81.3-1.7-0.7-1.20.50.0
Ambulatory time before self-admin0.71.01.4-1.11.20.60.8-1.01.2
Ambulatory time after self-admin0.40.51.30.5-0.6-0.6-0.50.8-1.1
Bone: tissue strength0.30.30.50.7-0.7-0.5-0.50.4-0.1
Total heroin consumption1.82.23.9-1.00.82.01.3-1.81.6
Bone: trabecular number0.10.10.30.4-0.5-0.1-0.40.4-0.4
Bone: trabecular spacing0.30.40.70.8-0.8-0.5-0.40.7-0.4
Bone: trabecular thickness0.10.10.2-0.40.3-0.00.10.3-0.4
Bone: trabecular tissue density0.30.51.1-0.30.2-0.8-0.21.1-1.0
Water consumed over 24 hours0.30.41.3-0.60.40.40.50.4-1.2
Number of responses in last shaping day3.43.75.6-1.71.61.91.7-2.22.4