H1f0

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	H1f0	0.03	0.02	7.1e-04	0.03	0.02	0.02	0.02	7.1e-05	2.2e-04	4.3e-04	3.5e-04
2	Liver	gene expression	H1f0	0.25	0.1	0.0e+00	0.2	0.16	0.21	0.21	4.4e-22	8.2e-18	1.2e-22	1.0e-22
3	Brain	gene expression	H1f0	0.1	0.05	9.8e-08	0.04	0.08	0.09	0.08	8.0e-05	5.8e-08	2.3e-08	9.1e-08
4	PL	gene expression	H1f0	0.03	0.02	7.3e-03	0	0.01	0.01	0.01	9.3e-02	1.7e-02	1.4e-02	3.6e-02
5	Adipose	gene expression	H1f0	0.09	0.05	3.8e-09	0.02	0.06	0.05	0.05	5.3e-03	5.7e-07	2.1e-06	1.6e-06
6	OFC	gene expression	H1f0	0.25	0.12	7.9e-04	0	0.14	0.12	0.1	2.8e-01	2.8e-04	9.1e-04	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.0	0.2	-0.1	0.0	0.1	0.1	0.1
Area under the delay curve	1.9	2.8	3.5	1.6	1.5	-1.9	-1.6	-1.8	1.8
BMI with tail	0.3	0.9	2.1	-0.9	-0.9	1.4	0.4	1.2	-0.4
BMI without tail	0.4	2.4	4.3	-1.0	-1.1	2.1	1.1	2.0	-1.7
Body weight	1.7	7.5	12.4	-2.6	-2.5	3.5	2.4	3.0	-2.3
Weight adjusted by age	0.3	1.0	1.5	-1.1	-1.0	0.9	1.2	0.9	-0.7
Bone surface	0.1	0.2	0.5	0.0	-0.1	-0.7	-0.3	-0.6	0.5
Bone volume	0.0	0.1	0.1	0.3	0.1	-0.3	-0.3	-0.2	0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.4	0.4	0.3	-0.4	-0.5	-0.5	0.6
Number of licking bursts	0.2	0.8	1.4	0.9	0.9	-1.2	-1.2	-0.2	-0.3
Context. condit. distance diff. score	3.1	3.8	6.9	-1.8	-1.7	2.6	2.3	1.5	-1.4
Locomotion velocity, session 1	0.6	0.7	1.8	-1.3	-1.3	-0.1	1.0	0.0	-0.1
Locomotion distance, session 1	3.0	3.9	8.8	1.5	1.4	-3.0	-1.9	-2.2	1.5
Locomotion velocity, session 2	1.0	1.2	2.7	-0.4	-0.5	-1.4	-0.6	-1.4	1.6
Locomotion distance, session 2	3.7	5.2	9.5	1.9	1.8	-3.1	-2.3	-2.5	1.9
Locomotion velocity, session 3	0.5	0.6	1.1	-0.9	-0.9	0.2	1.1	0.2	-0.9
Locomotion distance, session 3	0.8	0.9	1.4	1.2	1.1	-1.2	-0.9	-0.6	-0.5
Stereotopy head waving bouts, day 3	0.7	0.9	1.4	-1.2	-1.0	1.1	1.0	0.7	-0.2
Stereotopy head waving duration, day 3	3.3	4.1	6.7	-2.6	-2.4	2.1	2.3	1.4	-0.5
Locomotion velocity, session 7	1.2	1.4	1.6	-1.2	-1.2	0.9	1.3	1.3	-1.1
Locomotion distance, session 7	1.4	1.8	2.7	-0.9	-1.1	1.3	1.6	1.5	-1.5
Stereotopy head waving bouts, day 7	2.4	2.7	5.4	-2.3	-2.3	1.2	2.0	0.7	-0.2
Stereotopy head waving duration, day 7	1.6	2.0	4.3	-2.1	-2.0	1.0	1.6	0.3	0.3
Locomotion velocity, session 8	1.5	1.8	3.8	-1.9	-1.8	1.1	1.7	0.2	-0.0
Locomotion distance, session 8	0.2	0.4	0.8	-0.7	-0.7	0.5	0.9	-0.1	0.1
Degree of sensitization distance	5.6	6.0	8.9	-2.4	-2.5	3.0	2.9	2.3	-1.2
Degree of sensitization stereotypy	1.6	1.8	4.4	-2.1	-2.0	0.3	1.5	0.0	0.4
Conditioned locomotion	1.1	1.3	2.1	-1.4	-1.3	1.0	0.9	1.3	-1.0
Cocaine response after cond. corrected	0.2	0.3	0.9	-0.9	-0.6	-0.3	0.0	-0.1	0.7
Cocaine response after cond. not corrected	0.2	0.3	0.9	-0.5	-0.2	-0.5	-0.4	-0.4	1.0
Cocaine response before conditioning	0.6	0.8	1.4	1.2	1.1	-0.6	-1.0	-0.6	0.3
Saline control response	0.0	0.0	0.2	-0.1	0.0	0.2	0.1	0.0	-0.4
Bone: connectivity density	0.2	0.4	0.5	-0.6	-0.7	0.5	0.7	0.6	-0.6
Bone: cortical apparent density	0.4	0.7	2.4	0.7	0.7	-0.1	-0.5	0.8	-1.5
Bone: cortical area	0.2	0.4	1.4	-0.8	-1.2	0.0	0.3	0.3	0.2
Bone: cortical porosity	0.3	0.3	1.2	-0.5	-0.4	0.0	-0.1	-0.5	1.1
Bone: cortical porosity	0.7	0.8	1.7	-1.3	-1.2	0.2	0.5	-0.4	1.1
Bone: cortical thickness	0.8	1.3	2.6	1.3	1.0	-1.2	-1.6	-0.8	0.7
Bone: cortical thickness	1.6	2.0	3.7	1.4	1.4	-1.4	-1.9	-1.1	0.9
Bone: cortical tissue density	0.4	0.7	2.5	0.6	0.6	-0.0	-0.4	0.9	-1.6
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	0.5	0.5	-0.2	-0.5	0.5	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.4	-0.0	0.1	0.2	-0.0	0.6	-1.2
Condit. Reinf. active responses	0.6	0.8	1.7	1.1	1.0	-0.0	-0.6	0.7	-1.3
Condit. Reinf. inactive responses	0.6	0.8	1.9	1.4	1.2	0.3	-0.3	0.7	-1.0
Incentive salience index mean	0.5	0.7	2.4	0.5	0.4	0.2	-0.3	1.1	-1.6
Condit. Reinf. lever presses	0.7	1.0	3.2	0.5	0.3	0.7	-0.0	1.5	-1.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	0.2	0.4	0.2	0.1	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.2	-0.4	-0.3	0.5	0.5	-0.2	0.4
Condit. Reinf. active responses	0.4	0.5	1.6	0.1	0.2	-0.1	0.2	-1.2	1.2
Condit. Reinf. inactive responses	0.4	0.6	1.2	0.4	0.4	-1.0	-0.4	-1.1	0.8
Condit. Reinf. lever presses	0.2	0.2	0.5	0.7	0.7	0.3	-0.1	-0.4	0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	-0.1	-0.1	0.2	0.5	-0.9	1.1
Conditioned reinforcement - actives	1.1	4.5	5.5	2.0	2.4	-2.2	-2.4	-2.2	1.5
Conditioned reinforcement - inactives	1.3	3.5	5.8	2.4	2.4	-1.5	-2.3	-1.3	0.8
Conditioned locomotion	2.2	3.2	4.5	1.6	1.5	-1.6	-1.8	-2.1	2.1
Patch foraging indifference point 0 sec	0.3	0.9	2.3	-0.4	-0.6	0.9	0.6	1.2	-1.5
Patch foraging indifference point AUC	0.3	0.8	1.4	1.0	1.1	-1.2	-1.0	-0.6	-0.3
Delay disc. indifference point, 0s delay	0.2	0.3	1.0	0.5	0.1	-0.1	-0.4	-0.3	1.0
Delay disc. indifference point, 16s delay	2.0	2.9	3.8	1.5	1.6	-2.0	-1.6	-1.8	1.7
Delay disc. indifference point, 2s delay	9.6	10.7	15.2	2.8	2.4	-3.6	-3.0	-3.7	3.9
Delay disc. indifference point, 24s delay	0.2	0.4	1.1	-0.6	-0.4	-0.8	-0.0	0.4	-1.0
Delay disc. indifference point, 4s delay	1.5	1.6	3.4	1.0	0.8	-1.2	-0.9	-1.5	1.9
Delay disc. indifference point, 8s delay	0.6	1.0	1.9	1.4	1.3	-0.9	-1.0	-0.6	0.3
Indifference point function ln k	0.4	1.2	2.1	-1.4	-1.3	1.2	1.1	0.8	-0.3
Indifference point function log k	0.4	1.2	2.1	-1.4	-1.3	1.2	1.1	0.8	-0.3
Patch foraging total patch changes 0 sec	0.1	0.4	1.4	0.1	0.0	0.4	0.0	0.7	-1.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.4	-0.0	-0.1	-0.6	-0.2	-0.3	-0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	0.2	0.2	-0.2	-0.3	0.3	-0.7
Patch foraging total patch changes 24 sec	0.2	0.6	1.2	1.1	0.7	-0.4	-0.6	0.3	-1.1
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	0.5	0.4	-0.1	-0.3	0.1	-0.6
Patch foraging time to switch 0 sec	0.2	0.8	3.6	-0.4	-0.4	0.2	0.4	-0.8	1.9
Patch foraging water rate 0 sec	0.7	2.8	8.1	-0.8	-0.6	1.3	0.7	2.3	-2.9
Patch foraging water rate 12 sec	0.1	0.5	1.8	-0.0	-0.1	0.0	-0.4	1.0	-1.4
Patch foraging water rate 18 sec	0.9	1.9	5.9	-1.0	-0.7	0.7	0.6	1.8	-2.4
Patch foraging water rate 24 sec	2.2	3.1	3.9	-1.9	-1.6	1.7	1.4	2.0	-2.0
Patch foraging water rate 6 sec	0.9	1.3	4.8	0.3	0.3	0.4	-0.4	1.6	-2.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.2	-0.1	-0.2	0.3	-0.4	0.5
Distance traveled before self-admin	0.5	1.0	2.9	0.7	0.6	-0.7	-0.5	-1.2	1.7
Distance traveled after self-admin	0.4	0.8	0.9	-0.8	-0.8	0.9	0.8	1.0	-0.9
Extensor digitorum longus weight	0.7	3.0	4.2	1.9	1.8	-1.1	-1.9	-1.5	2.1
Bone: elastic displacement	1.0	1.2	1.8	-1.3	-1.3	1.0	1.3	0.9	-0.4
Bone: elastic work	2.3	3.0	6.6	-2.4	-2.6	1.1	1.8	0.9	0.2
Bone: endosteal estimation	1.0	2.5	5.2	-2.2	-2.3	1.0	1.8	0.7	-0.1
Bone: endosteal perimeter	1.2	2.8	6.5	-2.5	-2.6	0.9	1.7	0.7	0.1
Epididymis fat weight	0.6	3.2	5.8	-1.9	-2.0	2.4	1.7	1.5	-1.1
Delta time in closed arm before/after self-admin	1.9	1.8	3.0	1.3	1.6	-1.1	-1.7	-1.2	0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.5	-0.4	-0.0	0.6	-0.0	0.2
Diff in mean of infusions in LGA sessions	0.2	0.4	0.8	-0.7	-0.5	0.4	0.5	0.7	-0.9
Delay discount exponential model param	2.1	2.8	3.6	-1.6	-1.5	1.9	1.6	1.7	-1.7
Extinction: sum of active levers before priming	1.0	1.5	3.0	0.3	0.4	-1.6	-0.8	-1.6	1.7
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.3	-0.2	-0.4	-0.1	-0.4	0.6
Bone: final force	0.5	0.8	2.3	-1.3	-1.5	-0.0	0.6	0.1	0.6
Bone: final moment	0.6	1.0	2.9	-1.5	-1.7	0.3	0.8	0.3	0.4
Food consumed during 24 hour testing period	0.1	0.2	0.5	0.0	-0.0	-0.6	-0.4	-0.7	0.7
Glucose	0.3	0.5	1.1	0.3	0.3	0.8	-0.4	1.1	-0.9
Heart weight	4.0	6.4	10.8	-3.3	-3.1	2.2	2.5	2.2	-1.5
Delay discount hyperbolic model param	3.1	4.0	4.9	-1.9	-1.7	2.2	1.9	2.1	-2.1
Intermittent access intake day 1-15 change	0.1	0.3	0.6	0.8	0.6	-0.5	-0.7	-0.5	0.1
Intermittent access intake escalation	0.1	0.3	0.6	0.8	0.7	-0.5	-0.6	-0.4	-0.0
Intermittent access intake escalation 2	0.1	0.2	0.4	0.6	0.6	-0.0	-0.4	0.2	-0.5
Intermitt. access day 1 inactive lever presses	0.1	1.8	2.5	-1.2	-1.0	1.6	1.4	1.6	-1.3
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.4	-0.0	0.1	0.4	0.3	0.5	-0.6
Intermitt. access escalation Index	0.5	1.5	2.4	1.3	1.4	-1.3	-1.6	-0.9	0.5
Intermittent access day 1 total infusions	1.3	3.8	5.9	1.3	1.6	-2.2	-1.9	-2.4	2.0
Intermittent access day 15 total infusions	1.3	3.2	4.3	1.6	1.6	-2.1	-1.7	-2.1	1.5
Intermittent access terminal intake (last 3 days)	1.4	2.5	3.9	1.2	1.3	-2.0	-1.4	-1.9	1.4
Intermittent access total infusions	3.7	4.4	6.5	1.6	1.7	-2.4	-1.9	-2.5	2.2
Intermittent access day 1 locomotion	0.7	1.3	1.5	1.1	1.1	-1.2	-1.2	-1.2	1.0
Intermittent access day 15 total locomotion	0.2	0.7	1.0	0.9	0.7	-0.8	-1.0	-0.8	0.6
Intermittent access total locomotion	0.3	0.4	0.8	0.8	0.7	-0.3	-0.9	-0.4	0.3
Intermittent access standard deviation	0.0	0.1	0.4	0.0	-0.3	0.1	0.0	-0.2	0.6
Left kidney weight	2.1	16.6	31.9	-5.6	-5.5	3.5	4.6	2.0	-0.7
Right kidney weight	3.1	22.0	36.7	-6.1	-6.0	4.6	5.2	3.1	-1.6
Cocaine induced anxiety	0.1	0.2	0.7	-0.2	-0.8	0.4	0.6	-0.0	0.4
Post-drug Anxiety	1.4	1.6	2.6	-0.8	-1.3	1.6	1.3	1.4	-0.9
Baseline Anxiety	0.1	0.1	0.4	-0.0	0.2	0.1	-0.1	0.6	-0.6
Tail length	0.6	3.4	6.6	-0.7	-0.7	2.3	1.4	2.3	-2.6
Length with tail	1.6	7.0	10.1	-2.4	-2.2	3.2	2.6	2.8	-2.7
Length without tail	1.1	6.0	9.2	-3.0	-3.0	2.4	2.6	1.9	-1.3
Times rat made contact with spout	1.1	1.3	4.1	0.9	1.0	-0.4	-1.0	0.8	-2.0
Lifetime Intake	3.6	4.5	6.6	1.6	1.6	-2.4	-2.0	-2.6	2.3
Liver weight, left	0.0	0.0	0.2	0.1	0.2	0.1	-0.2	-0.4	0.1
Liver weight, right	0.9	1.6	2.4	-1.2	-1.0	1.5	0.9	1.2	-1.6
Locomotor activity	0.3	0.4	1.1	-1.0	-1.0	0.4	0.4	0.4	-0.3
Locomotor testing distance	0.2	0.5	1.6	0.6	0.7	-0.8	-1.3	-0.0	-0.3
Locomotor testing rearing	0.1	0.2	0.5	-0.4	-0.2	-0.7	-0.7	-0.3	0.2
Locomotion in novel chamber	1.2	1.7	4.4	1.7	2.1	-0.5	-1.5	-0.5	0.1
Locomotion in novel chamber post-restriction	1.2	3.6	5.2	2.1	2.3	-1.8	-2.3	-1.6	1.2
Fecal boli incidents, locomotor time 1	0.2	0.4	1.0	-0.7	-0.4	0.3	0.3	0.9	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	1.0	-0.7	-0.7	0.4	0.5	0.5	-1.0
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.2	-1.1	-0.9	0.3	0.5	0.4	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	-0.3	0.2	0.0	0.3	-0.4
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	-0.5	0.4	0.3	0.5	-0.4
Rest time, locomotor task time 1	0.7	1.1	1.6	-0.8	-0.8	1.2	1.1	1.2	-1.1
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.2	-0.1	-0.3	-0.2	-0.3	0.2
Vertical activity count, locomotor time 1	0.2	1.1	2.5	-0.1	-0.2	1.2	0.3	1.5	-1.6
Time >=10cm from walls, locomotor time 2	1.0	2.7	4.3	-1.9	-1.6	1.0	1.1	2.1	-1.9
Bouts of movement, locomotor time 2	1.3	4.4	7.0	2.0	1.8	-1.9	-2.6	-2.0	2.1
Total resting periods, locomotor time 2	1.2	4.9	6.7	2.1	1.8	-2.0	-2.6	-2.3	2.4
Rest time, locomotor task time 2	0.1	0.1	0.3	0.3	-0.0	0.6	0.3	0.0	0.1
Distance moved, locomotor task time 2	0.8	1.0	1.7	-1.3	-1.1	0.4	0.9	1.1	-1.0
Vertical activity count, locomotor time 2	0.6	1.5	3.6	-0.8	-0.8	0.7	0.4	1.9	-1.8
Light reinforcement 1	0.0	0.1	0.3	-0.3	-0.3	-0.5	0.1	-0.2	0.3
Light reinforcement 2	0.2	0.4	1.0	-0.0	0.0	-0.8	-0.6	-0.7	1.0
Bone: marrow area	1.1	2.7	5.6	-2.3	-2.4	1.1	1.9	0.7	-0.1
Bone: maximum diameter	1.3	2.7	6.8	-2.3	-2.6	0.9	1.6	0.8	0.1
Bone: maximum force	0.4	0.8	2.4	-1.4	-1.6	-0.0	0.5	0.1	0.6
Bone: maximum moment	0.6	1.1	3.1	-1.6	-1.8	0.2	0.8	0.2	0.5
Mean time between licks in bursts	0.1	0.8	2.9	-0.1	0.1	-0.8	-0.4	-1.0	1.7
Mean num. licks in bursts	0.1	0.4	1.2	-0.2	-0.1	0.6	0.4	0.6	-1.1
Cd content in liver	0.7	0.7	1.9	0.3	0.3	-1.4	-1.1	-0.9	0.5
Co content in liver	0.8	0.9	2.2	0.7	1.1	-1.0	-1.5	-0.4	0.4
Cu content in liver	1.7	2.0	5.2	1.9	2.3	-0.8	-1.6	-0.4	-0.0
Fe content in liver	4.0	4.9	7.8	-2.8	-2.8	2.2	2.7	1.4	-0.5
K content in liver	0.1	0.1	0.4	0.1	0.6	0.5	-0.0	0.2	-0.4
Mg content in liver	0.1	0.1	0.3	0.0	0.5	0.2	-0.2	0.3	-0.5
Mn content in liver	0.6	0.7	1.4	0.9	1.2	-0.7	-0.9	-0.8	0.4
Na content in liver	0.5	0.5	1.1	-0.2	-0.0	1.0	0.5	0.9	-0.9
Rb content in liver	0.0	0.0	0.1	-0.2	-0.2	0.3	0.3	0.2	-0.1
Se content in liver	0.7	0.9	1.5	0.8	1.0	-0.9	-1.2	-0.9	0.5
Sr content in liver	2.6	2.3	5.1	2.3	2.2	-1.0	-1.5	-0.7	0.3
Zn content in liver	0.3	0.4	0.9	0.5	0.9	-0.4	-0.9	-0.2	-0.4
Bone: minimum diameter	0.1	0.2	0.5	-0.6	-0.7	-0.1	0.3	-0.2	0.4
Time in familiar zone, hab. session 1	0.5	0.5	1.1	-0.8	-1.0	0.4	0.9	0.5	-0.3
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	-0.1	0.2
Total zone transitions, hab. session 1	1.6	2.3	3.5	1.9	1.8	-1.6	-1.4	-1.4	0.5
Total locomotion distance, hab. session 1	0.7	1.0	1.6	1.3	1.2	-1.0	-1.1	-0.8	-0.0
Locomotion velocity, hab. session 1	0.9	1.2	2.1	1.4	1.4	-1.1	-1.2	-0.8	-0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.2	0.2	-0.5	-0.5	0.1	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.5	0.6	0.0	-0.3	-0.5	0.6
Total zone transitions, hab. session 2	0.3	0.4	0.7	0.7	0.8	-0.9	-0.7	-0.3	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.4	0.5	-0.6	-0.4	-0.7	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.4	0.5	-0.3	-0.2	-0.4	0.2
Novel to familiar place preference ratio	0.3	0.4	0.9	-0.9	-0.9	0.4	0.7	0.1	-0.2
Novelty place preference	0.3	0.3	0.8	-0.9	-0.9	0.3	0.5	0.1	-0.4
Time in novel zone, NPP test	0.3	0.4	0.8	-0.9	-0.9	0.4	0.6	0.2	-0.4
Total zone transitions, NPP test	1.2	1.7	2.6	1.6	1.6	-1.6	-1.3	-1.1	0.2
Total locomotion distance, NPP test	0.1	0.2	0.7	0.2	0.3	-0.8	-0.2	-0.5	0.1
Locomotion velocity, NPP test	0.3	0.4	1.1	0.6	0.6	-1.1	-0.5	-0.7	0.2
Intraocular pressure	0.2	0.3	0.8	-0.9	-0.9	0.1	0.5	-0.2	0.2
Delta distance traveled before/after self-admin	3.5	3.8	7.0	-1.6	-1.8	1.7	1.7	2.1	-2.6
Delta ambulatory time before/after self-admin	2.1	3.5	5.7	-1.9	-2.0	1.3	1.7	1.9	-2.4
Parametrial fat weight	1.1	2.5	5.2	-0.6	-0.5	1.9	0.8	2.3	-2.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	-0.2	0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	0.8	0.4	-1.1	-0.9	-0.9	1.2
Pavlov. Cond. change in total contacts	1.3	1.4	2.5	1.2	1.0	-1.6	-1.2	-1.1	1.0
Pavlov. Cond. index score	0.1	0.1	0.3	0.4	-0.1	-0.6	-0.3	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.1	0.2	0.3	-0.1	-0.4	-0.2	-0.0	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.5	0.1	-0.2	-0.1	0.3	-0.3
Pavlov. Cond. magazine entry number	0.6	0.8	1.3	-1.0	-0.6	1.1	0.9	0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.3	0.1	0.2	0.5	0.3	1.0	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	0.5	0.1	-0.7	-0.4	-0.2	0.3
Pavlov. Cond. response bias	0.2	0.2	0.5	0.7	0.2	-0.7	-0.5	-0.2	0.3
Pavlov. Cond. lever latency	0.7	1.0	2.0	0.6	0.6	-1.4	-1.2	-1.1	0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.9	0.8	0.1	-0.4	-0.0	0.0
Pavlov. Cond. change in total contacts	2.0	5.0	7.2	-2.3	-2.3	2.7	2.6	2.1	-1.1
Pavlov. Cond. index score	0.5	0.8	1.8	-0.3	-0.4	1.3	1.0	1.0	-0.7
Pavlov. Cond. latency score	0.5	0.8	1.8	-0.3	-0.3	1.3	1.0	1.2	-0.9
Pavlov. Cond. lever contacts	0.7	1.0	2.1	-0.6	-0.6	1.5	1.1	1.1	-0.8
Pavlov. Cond. magazine entry number	0.4	0.6	1.7	0.2	0.2	-1.3	-0.9	-0.8	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.1	-0.1	0.5	0.4	0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.8	-0.3	-0.4	1.3	1.0	0.9	-0.5
Pavlov. Cond. response bias	0.5	0.6	1.6	-0.5	-0.5	1.3	1.1	0.8	-0.3
Time in closed arm before self-admin	0.1	0.2	0.3	0.5	0.2	0.5	0.1	0.6	-0.1
Time in closed arm after self-admin	0.4	0.4	0.6	0.5	0.7	0.7	-0.5	0.6	-0.8
Time in open arm before self-admin	0.3	0.3	1.0	-0.3	-0.4	0.3	0.5	0.6	-1.0
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.2	-0.0	-0.1
Bone: periosteal estimation	0.8	1.8	4.8	-1.9	-2.2	0.6	1.3	0.5	0.2
Bone: periosteal perimeter	1.8	3.5	8.6	-2.7	-2.9	0.9	1.7	1.0	-0.3
Bone: post-yield work	0.2	0.4	1.2	-0.3	-0.3	-1.1	-0.4	-0.5	0.5
Progressive ratio test 1 active lever presses	1.6	2.9	4.6	1.2	1.3	-2.0	-1.5	-2.1	1.9
Progressive ratio test 1 breakpoint	1.5	2.6	4.1	1.2	1.2	-1.9	-1.4	-2.0	1.8
Progressive ratio test 1 inactive lever presses	0.7	1.9	3.9	1.3	1.3	-0.9	-1.0	-1.5	2.0
Progressive ratio test 2 active lever presses	2.7	3.9	4.5	2.0	2.1	-2.1	-2.1	-2.0	1.4
Progressive ratio test 2 breakpoint	3.4	4.3	5.0	2.0	2.2	-2.2	-2.2	-2.2	1.7
Progressive ratio test 2 inactive lever presses	1.2	3.8	5.5	2.3	2.3	-2.0	-2.1	-1.6	0.9
Incentive Sensitization - Responses	0.5	1.4	2.5	1.4	1.6	-1.1	-1.4	-0.9	0.4
Incentive Sensitization - Breakpoint	0.7	1.5	2.7	1.4	1.6	-1.1	-1.4	-0.9	0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	0.1	0.3	-0.1	0.1	0.1
Progressive ratio	0.0	0.1	0.1	-0.1	-0.2	0.2	0.4	-0.2	0.4
Food seeking constrained by brief footshock	0.8	1.0	2.2	0.2	0.3	-1.5	-1.3	-1.1	1.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.6	0.0	0.2	-0.7	-0.8	-0.2	0.2
Retroperitoneal fat weight	1.3	5.9	10.5	-3.2	-3.0	2.4	2.2	2.1	-0.9
Reaction time number correct	0.3	1.0	1.9	1.0	0.9	-1.4	-1.1	-0.9	0.1
Reaction time mean minus median	0.0	0.1	0.3	-0.2	-0.1	0.5	0.6	0.1	0.1
Reaction time mean minus median AUC	0.0	0.2	0.7	-0.3	-0.2	0.9	0.6	0.3	-0.1
Reaction time num false alarms	0.1	0.2	0.6	0.2	0.3	-0.5	-0.8	-0.2	-0.1
Reaction time num false alarms AUC	0.1	0.3	0.8	0.3	0.4	-0.6	-0.9	-0.4	-0.0
Reaction time trials correct on left	0.3	1.0	1.9	1.0	0.9	-1.4	-1.1	-0.9	0.1
Reaction time trials on left	0.4	1.2	2.3	1.2	1.1	-1.5	-1.2	-1.1	0.2
Reaction time mean	0.4	0.9	2.0	-0.8	-0.7	1.4	1.2	0.9	-0.4
Reaction time mean AUC	0.2	0.5	1.3	-0.5	-0.4	1.1	1.0	0.6	-0.2
Median of all reaction times	0.5	0.8	1.8	-0.8	-0.7	1.3	1.1	0.9	-0.3
Reaction time omissions	2.8	4.5	6.6	1.6	1.7	-2.1	-2.1	-2.5	2.6
Reaction time false alarm rate	0.0	0.0	0.2	-0.1	0.1	0.0	-0.4	0.0	0.0
Reaction time premature initiation rate	0.1	0.1	0.5	-0.4	-0.7	-0.0	0.1	0.2	0.1
Reaction time premature initiations	0.0	0.1	0.3	0.1	-0.1	-0.5	-0.4	-0.1	-0.0
Std. dev. reaction times	0.1	0.5	1.0	-0.5	-0.5	1.0	0.9	0.5	-0.3
Reaction time trials completed	0.4	1.2	2.3	1.2	1.1	-1.5	-1.2	-1.1	0.2
Reaction time trials AUC	0.3	0.9	1.9	1.0	0.8	-1.4	-1.0	-1.0	0.1
Run reversals in cocaine runway, females	0.9	1.0	1.3	-0.6	-0.8	1.1	1.1	1.1	-1.1
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.6	0.0	-0.6	0.1	-0.4	-0.4
Latency to leave start box in cocaine runway	0.4	0.6	1.6	-0.9	-0.7	0.0	0.6	-0.6	1.3
Latency to leave start box in cocaine runway, F	0.5	0.6	1.3	-0.9	-0.9	-0.2	0.6	-0.4	1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.2	0.2	0.4	0.2	-0.4	0.5
Std. dev. time between licks in bursts	0.2	0.4	0.6	-0.8	-0.6	0.7	0.8	0.5	-0.4
Total sessions with >9 infusions	0.8	1.0	2.4	0.0	0.0	-1.1	-0.4	-1.4	1.5
Short access day 1 total inactive lever presses	0.7	1.4	2.6	-1.3	-1.3	1.3	1.6	0.8	-0.4
Short access day 10 total inactive lever presses	0.8	5.7	9.3	-1.8	-1.8	2.4	2.2	2.9	-3.1
Short access day 1 total infusions	0.1	0.1	0.2	-0.5	-0.4	0.2	0.4	0.1	-0.1
Short access day 10 total infusions	0.7	1.2	2.6	0.3	0.1	-1.3	-0.5	-1.6	1.6
Short access total infusions	1.1	1.6	3.0	0.5	0.5	-1.5	-0.9	-1.7	1.7
Short access day 1 locomotion	0.0	0.1	0.2	-0.2	-0.1	0.4	0.3	0.1	-0.2
Short access day 10 total locomotion	0.1	0.5	1.0	0.5	0.3	0.9	-0.1	1.0	-0.9
Short access total locomotion	0.0	0.1	0.2	0.4	0.2	0.1	-0.2	-0.2	0.4
One hour access (0.3 mA shock)	8.2	9.7	11.5	3.2	3.3	-3.4	-3.4	-3.1	2.2
Compulsive drug intake	0.3	0.5	1.0	0.9	1.0	-0.2	-0.5	0.3	-0.8
One hour access (shock baseline)	1.6	4.2	5.8	1.7	1.8	-2.1	-2.0	-2.4	2.2
Social response proportion	1.2	1.5	6.1	-0.6	-0.8	-0.4	0.3	-1.2	2.5
Social responses	0.7	0.9	1.9	0.3	0.1	-1.2	-0.6	-1.2	1.4
Social time	1.2	1.9	2.8	1.3	1.4	-1.6	-1.7	-1.1	1.2
Soleus weight	0.5	1.4	3.5	1.0	0.8	0.6	-0.7	1.5	-1.9
Bone: stiffness	0.5	1.0	2.3	-1.4	-1.5	0.5	0.7	0.8	-0.1
Tibialis anterior weight	2.4	8.3	12.8	3.6	3.5	-2.2	-3.2	-2.3	2.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.6	0.6	-0.3	-0.5	-0.6	0.7
Time to tail flick, vehicle, after self-admin	0.7	1.4	3.5	-0.6	-0.0	1.4	0.5	1.6	-1.9
Time to tail flick, test, before self-admin	1.8	2.0	2.5	1.6	1.4	-1.4	-1.4	-1.6	1.1
Time to tail flick, test, after self-admin	0.2	0.2	0.9	-0.0	0.1	0.2	-0.1	0.7	-0.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	-1.0	-0.7	0.7	0.9	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.4	0.5	1.3	0.0	0.2	0.6	-0.1	1.1	-1.1
Tibia length	0.4	1.1	2.8	-1.3	-1.7	0.8	1.2	0.5	0.0
Ambulatory time before self-admin	0.3	1.0	1.4	1.1	1.2	-0.6	-0.8	-1.0	1.2
Ambulatory time after self-admin	0.3	0.5	1.3	-0.5	-0.6	0.6	0.5	0.8	-1.1
Bone: tissue strength	0.3	0.3	0.5	-0.7	-0.7	0.5	0.5	0.4	-0.1
Total heroin consumption	1.8	2.1	3.9	1.0	0.8	-2.0	-1.3	-1.8	1.6
Bone: trabecular number	0.1	0.1	0.3	-0.4	-0.5	0.1	0.4	0.4	-0.4
Bone: trabecular spacing	0.3	0.4	0.7	-0.8	-0.8	0.6	0.4	0.7	-0.4
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.3	-0.0	-0.1	0.3	-0.4
Bone: trabecular tissue density	0.3	0.5	1.1	0.3	0.2	0.8	0.2	1.1	-1.0
Water consumed over 24 hours	0.2	0.4	1.3	0.6	0.4	-0.4	-0.5	0.4	-1.2
Number of responses in last shaping day	2.9	3.7	5.6	1.7	1.6	-1.9	-1.7	-2.2	2.4