Gtse1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Gtse1	0.04	0.03	4.5e-04	0.02	0.01	0	0.01	2.6e-03	1.2e-02	8.5e-02	1.4e-02
2	Brain	mRNA stability	Gtse1	0.02	0.02	9.9e-03	0.01	0.02	0.01	0.01	9.0e-02	1.0e-02	2.9e-02	4.0e-02
3	LHb	gene expression	Gtse1	0.17	0.11	7.5e-03	0.04	0.04	0.01	0.03	4.6e-02	4.8e-02	2.2e-01	6.7e-02
4	Brain	intron excision ratio	chr7_116965444_116965769	0.03	0.02	6.0e-04	0.04	0.03	0.03	-0	1.1e-04	5.9e-04	9.5e-04	8.0e-01
5	Adipose	gene expression	Gtse1	0.13	0.14	3.3e-03	0	0.01	0.05	0	9.6e-02	2.0e-02	3.3e-06	7.9e-02
6	Brain	gene expression	Gtse1	0.13	0.16	2.4e-03	0.04	0.02	0.04	0.02	3.1e-04	4.0e-03	2.3e-04	2.8e-03
7	Liver	gene expression	Gtse1	0.42	0.09	0.0e+00	0.45	0.47	0.46	0.47	3.5e-55	1.4e-57	6.6e-57	1.5e-57

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.6	1.1	2.1	-1.0	1.2	-1.1	1.3	-1.4	0.0	0.1
Area under the delay curve	3.7	3.9	6.9	-2.3	2.3	-1.8	2.6	0.4	-2.6	0.3
BMI with tail	2.4	7.7	12.5	3.5	-2.7	2.0	-3.5	3.5	0.1	-2.5
BMI without tail	1.7	3.5	8.6	1.4	-2.2	2.1	-1.8	2.9	1.4	0.1
Body weight	1.8	7.7	12.5	3.2	-3.3	3.5	-3.4	2.4	1.5	-0.4
Weight adjusted by age	1.6	1.8	4.8	1.3	-1.5	1.2	-2.2	0.9	0.8	-0.8
Bone surface	0.3	0.5	0.9	-0.9	0.7	-0.5	0.6	-1.0	0.7	0.2
Bone volume	0.4	0.6	1.0	-1.0	0.8	-0.6	1.0	-0.9	0.5	0.4
Breakpoint value in progressive ratio session	0.6	0.7	1.7	0.0	0.5	-1.3	0.2	0.1	-1.0	-1.2
Number of licking bursts	0.4	0.5	1.7	-0.8	0.3	0.4	0.5	-0.7	0.4	1.3
Context. condit. distance diff. score	0.8	1.0	2.0	1.2	-1.4	0.6	-0.9	-1.2	1.0	-0.2
Locomotion velocity, session 1	1.9	2.1	5.8	0.8	-1.4	1.7	-0.9	2.4	1.3	0.8
Locomotion distance, session 1	0.4	0.5	1.6	-0.9	0.1	0.2	0.6	0.7	0.5	1.3
Locomotion velocity, session 2	4.2	4.9	14.8	1.8	-2.2	2.6	-1.8	3.8	1.2	0.4
Locomotion distance, session 2	0.3	0.5	0.9	-0.5	0.6	-0.7	0.6	1.0	-0.8	-0.4
Locomotion velocity, session 3	3.3	3.8	6.1	0.9	-2.2	2.5	-0.9	2.0	2.5	2.0
Locomotion distance, session 3	0.8	0.9	3.1	-0.3	-0.5	1.1	0.3	0.6	1.0	1.8
Stereotopy head waving bouts, day 3	0.4	0.5	1.6	0.5	-1.3	0.7	-0.7	0.6	0.7	-0.1
Stereotopy head waving duration, day 3	1.1	1.3	3.5	0.9	-1.9	0.9	-1.3	0.8	1.3	-0.4
Locomotion velocity, session 7	1.2	1.3	2.7	0.7	-1.6	1.5	-0.9	1.0	1.2	0.9
Locomotion distance, session 7	0.2	0.3	0.6	0.6	-0.5	0.8	-0.2	0.2	0.3	0.8
Stereotopy head waving bouts, day 7	0.8	1.0	2.5	0.8	-1.6	1.0	-0.8	0.3	1.3	0.2
Stereotopy head waving duration, day 7	0.4	0.4	1.1	0.4	-1.0	0.6	-0.4	-0.2	1.1	0.3
Locomotion velocity, session 8	3.6	4.3	6.8	2.6	-2.6	1.9	-2.2	2.3	0.9	-1.1
Locomotion distance, session 8	0.4	0.5	1.2	1.0	-1.1	0.8	-0.7	0.2	0.5	0.2
Degree of sensitization distance	0.9	0.9	2.2	1.5	-0.6	0.2	-1.0	0.6	-0.7	-1.4
Degree of sensitization stereotypy	0.6	0.7	2.1	0.6	-1.1	0.7	-0.7	0.2	1.4	0.1
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.3	0.1	-0.3	-0.1	0.1	0.1
Cocaine response after cond. corrected	0.3	0.4	1.1	0.6	-0.3	1.1	-0.5	0.7	0.3	0.5
Cocaine response after cond. not corrected	0.4	0.5	1.3	0.3	-0.3	1.1	-0.1	0.8	0.4	1.1
Cocaine response before conditioning	0.2	0.3	0.8	-0.7	0.3	-0.2	0.8	0.2	-0.0	0.9
Saline control response	0.2	0.2	0.6	0.8	-0.2	0.4	-0.6	-0.1	0.5	0.0
Bone: connectivity density	0.3	0.5	0.8	-0.9	0.7	-0.5	0.9	-0.8	0.3	0.6
Bone: cortical apparent density	1.0	1.4	2.5	-1.3	1.4	-1.2	1.1	-1.6	-0.8	0.0
Bone: cortical area	1.0	1.5	3.4	1.7	-1.2	1.0	-1.8	0.7	0.5	-1.2
Bone: cortical porosity	1.2	1.3	2.8	1.7	-0.9	0.9	-1.4	1.3	-0.3	-1.2
Bone: cortical porosity	1.1	1.2	2.3	1.5	-0.8	0.7	-1.3	1.2	-0.3	-1.3
Bone: cortical thickness	0.3	0.4	1.2	0.2	0.3	-0.4	-0.6	-0.7	-0.8	-1.1
Bone: cortical thickness	1.3	1.5	3.6	1.6	-1.0	0.3	-1.9	0.0	-0.3	-1.8
Bone: cortical tissue density	0.8	1.1	2.2	-1.2	1.2	-1.1	1.0	-1.5	-0.8	-0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.2	0.6	0.1	0.4	0.2	-0.9	0.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.9	-1.0	1.2	-0.6	1.0	-1.4	-0.9	0.3
Condit. Reinf. active responses	0.4	0.5	1.2	-0.6	0.8	0.1	1.1	0.2	-0.6	1.0
Condit. Reinf. inactive responses	0.4	0.5	1.5	-0.2	0.1	0.3	0.9	0.7	0.4	1.2
Incentive salience index mean	0.5	0.6	1.9	0.6	-0.3	1.4	-0.4	1.2	0.0	0.7
Condit. Reinf. lever presses	1.8	2.4	5.4	1.4	-1.3	2.3	-1.2	1.8	1.3	1.2
Condit. Reinf. active minus inactive responses	0.5	0.7	1.9	1.0	-0.5	0.4	-0.7	1.4	0.2	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	-0.1	0.1	-0.4	-0.2	0.5	-0.4
Condit. Reinf. active responses	1.5	2.1	5.3	1.8	-1.2	0.9	-1.5	2.3	0.4	-1.4
Condit. Reinf. inactive responses	2.5	3.1	8.7	2.0	-1.8	1.2	-1.7	2.9	0.3	-1.2
Condit. Reinf. lever presses	0.6	0.8	1.6	1.0	-1.0	0.4	-0.9	1.3	0.6	-0.7
Condit. Reinf. lever reinforcers received	1.2	1.7	4.8	1.5	-0.9	0.7	-1.2	2.2	0.2	-1.3
Conditioned reinforcement - actives	0.8	0.8	2.0	0.2	-0.1	0.7	0.6	-1.4	0.6	1.4
Conditioned reinforcement - inactives	0.4	0.5	1.6	1.3	-0.7	0.3	-0.6	-0.4	0.8	0.1
Conditioned locomotion	1.7	2.0	3.3	1.8	-1.6	1.7	-1.4	1.5	1.1	0.2
Patch foraging indifference point 0 sec	0.1	0.2	1.1	-0.0	0.4	0.4	0.3	0.1	-1.0	-0.1
Patch foraging indifference point AUC	0.3	0.4	2.1	-0.4	0.5	-0.1	0.2	1.4	-0.4	0.1
Delay disc. indifference point, 0s delay	0.3	0.4	1.4	0.0	0.0	0.0	0.3	1.2	-1.1	-0.0
Delay disc. indifference point, 16s delay	3.5	3.5	6.3	-2.5	2.4	-1.9	2.2	-0.6	-1.9	0.3
Delay disc. indifference point, 2s delay	0.9	0.9	3.0	-0.8	1.0	-0.9	0.8	0.6	-1.7	-0.2
Delay disc. indifference point, 24s delay	1.2	1.2	4.6	0.0	0.5	-0.2	0.1	2.2	-1.6	-0.9
Delay disc. indifference point, 4s delay	4.5	4.8	8.1	-2.6	2.4	-2.3	2.7	0.0	-2.8	0.1
Delay disc. indifference point, 8s delay	3.6	3.7	6.5	-2.2	2.2	-1.8	2.6	-0.6	-2.5	0.2
Indifference point function ln k	1.9	2.6	4.4	2.1	-2.1	1.9	-1.7	-0.4	1.7	0.1
Indifference point function log k	1.9	2.6	4.4	2.1	-2.1	1.9	-1.7	-0.4	1.7	0.1
Patch foraging total patch changes 0 sec	0.2	0.3	1.3	-0.4	0.6	0.1	0.6	-0.3	-1.1	0.0
Patch foraging total patch changes 12 sec	0.2	0.3	1.2	-0.0	0.0	0.3	-0.2	1.1	-0.7	-0.5
Patch foraging total patch changes 18 sec	0.4	0.5	1.0	-1.0	0.9	0.1	0.7	0.8	-0.6	0.6
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	-0.5	0.2	0.2	0.9	0.3	-0.8	0.4
Patch foraging total patch changes 6 sec	0.7	1.0	4.0	-1.0	1.1	-0.5	0.8	0.3	-2.0	-0.3
Patch foraging time to switch 0 sec	0.2	0.4	1.1	-1.0	0.4	-1.0	0.3	-0.0	0.0	-0.5
Patch foraging water rate 0 sec	0.3	0.6	1.2	1.1	-0.6	0.7	-0.8	0.9	-0.3	-0.5
Patch foraging water rate 12 sec	0.6	0.9	2.3	1.1	-0.7	1.5	-0.4	1.2	-0.0	0.8
Patch foraging water rate 18 sec	0.2	0.2	0.8	0.7	-0.3	0.9	-0.3	-0.2	0.2	0.2
Patch foraging water rate 24 sec	0.4	0.5	2.0	1.4	-0.6	0.4	-0.7	0.1	-0.6	-0.6
Patch foraging water rate 6 sec	0.4	0.6	1.7	-0.0	-0.1	1.1	-0.2	0.9	-0.1	1.3
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	2.3	-1.1	1.3	-1.5	1.3	-1.3	-0.3	-0.2
Distance traveled before self-admin	0.3	0.4	0.7	0.4	-0.7	0.7	-0.0	0.5	0.8	0.7
Distance traveled after self-admin	0.9	1.0	1.6	1.3	-0.9	0.2	-1.2	1.0	1.1	-0.8
Extensor digitorum longus weight	0.3	1.1	2.2	1.2	-1.3	0.9	-1.3	0.0	1.5	-0.2
Bone: elastic displacement	0.5	0.6	1.3	0.6	-0.7	1.0	-0.8	1.1	0.3	0.6
Bone: elastic work	2.6	3.3	5.6	2.2	-2.0	1.4	-2.4	2.1	0.8	-1.2
Bone: endosteal estimation	1.4	3.1	5.6	2.2	-2.4	1.7	-1.7	1.6	1.4	-0.6
Bone: endosteal perimeter	2.5	5.1	7.7	2.7	-2.8	2.6	-2.5	2.2	1.7	-0.5
Epididymis fat weight	0.3	0.6	1.2	1.1	-0.7	1.0	-1.0	-0.9	0.2	0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.1	0.2	-0.4	-0.4	-0.4	-0.7	-0.8
Delta time in open arm before/after self-admin	1.0	0.9	3.0	-0.4	-0.5	0.8	0.3	-0.4	1.5	1.7
Diff in mean of infusions in LGA sessions	0.9	1.0	2.9	0.9	0.4	-0.6	-0.3	-0.2	-1.7	-1.6
Delay discount exponential model param	3.8	4.0	7.3	2.3	-2.3	1.7	-2.6	-0.7	2.7	-0.3
Extinction: sum of active levers before priming	0.6	0.6	1.8	-0.0	0.8	-1.3	0.6	-0.6	-0.6	-0.9
Active lever presses in extinction session 6	1.1	1.1	2.8	1.1	-0.5	-0.2	-0.8	1.1	-1.2	-1.7
Bone: final force	0.8	1.3	5.4	1.3	-0.5	-0.4	-1.1	0.1	-0.4	-2.3
Bone: final moment	1.0	1.6	6.7	1.4	-0.6	-0.4	-1.4	0.2	-0.2	-2.6
Food consumed during 24 hour testing period	3.8	4.6	6.8	2.6	-2.4	2.3	-2.6	1.5	2.0	-1.1
Glucose	0.2	0.4	1.4	0.2	0.5	0.0	-0.4	0.6	-1.2	-0.6
Heart weight	0.9	1.2	4.7	-0.7	0.5	-1.5	0.5	-2.2	0.4	-0.7
Delay discount hyperbolic model param	3.6	3.8	7.4	2.2	-2.2	1.7	-2.5	-0.8	2.7	-0.3
Intermittent access intake day 1-15 change	0.5	0.5	1.8	0.9	-0.2	0.2	-0.7	-0.2	1.4	-0.1
Intermittent access intake escalation	0.8	0.8	2.0	1.3	-0.6	0.5	-1.0	-0.4	1.4	-0.0
Intermittent access intake escalation 2	0.4	0.4	0.7	0.6	0.4	-0.5	-0.9	0.7	0.3	-0.8
Intermitt. access day 1 inactive lever presses	1.8	1.9	6.9	0.7	-0.2	-0.9	-0.4	2.6	-1.5	-1.7
Intermitt. access day 15 inactive lever presses	1.9	2.1	5.4	2.3	-1.1	0.4	-1.6	1.0	-0.3	-2.0
Intermitt. access escalation Index	0.5	0.4	2.4	0.5	-0.4	0.5	-0.3	-1.5	0.1	-0.1
Intermittent access day 1 total infusions	1.8	2.0	4.0	2.0	-1.9	2.0	-0.9	-0.0	1.1	0.9
Intermittent access day 15 total infusions	2.2	2.4	5.6	2.4	-1.7	1.6	-1.3	-0.8	1.8	0.5
Intermittent access terminal intake (last 3 days)	3.2	3.5	8.4	2.9	-2.1	2.0	-1.9	0.6	1.7	0.1
Intermittent access total infusions	2.8	3.1	7.2	2.7	-2.1	2.0	-1.7	-0.0	1.6	0.2
Intermittent access day 1 locomotion	1.2	1.3	3.0	1.2	-1.3	1.7	-0.1	-0.9	0.6	1.3
Intermittent access day 15 total locomotion	2.2	2.4	4.2	2.0	-1.9	2.0	-0.8	-0.7	1.5	1.1
Intermittent access total locomotion	1.6	1.9	5.1	2.2	-1.8	1.5	-1.1	0.4	1.1	0.3
Intermittent access standard deviation	0.7	0.8	2.0	1.4	-0.5	0.2	-1.3	0.7	-0.2	-1.0
Left kidney weight	8.0	22.6	38.9	5.9	-6.2	4.5	-6.0	3.4	3.4	-2.3
Right kidney weight	7.8	21.9	38.0	6.0	-5.9	4.0	-6.2	3.8	2.4	-2.9
Cocaine induced anxiety	2.3	2.7	5.5	1.6	-0.9	-0.0	-1.5	2.4	-1.5	-2.3
Post-drug Anxiety	2.6	2.9	9.8	1.2	-0.1	-1.3	-1.1	1.6	-1.9	-3.1
Baseline Anxiety	1.6	1.8	7.4	-1.0	1.2	-1.1	0.9	-2.7	0.6	0.4
Tail length	0.7	2.0	8.1	-1.0	-0.4	1.6	0.8	0.5	1.2	2.8
Length with tail	0.6	2.1	6.1	1.0	-1.5	2.5	-1.0	0.5	1.3	1.7
Length without tail	0.8	1.7	5.0	2.2	-1.1	1.1	-1.9	-0.5	0.3	-0.9
Times rat made contact with spout	0.8	1.0	3.6	0.4	-1.0	1.0	-0.5	-0.2	1.9	0.8
Lifetime Intake	3.0	3.4	7.0	2.7	-2.3	2.2	-1.7	0.4	1.9	0.4
Liver weight, left	0.4	0.6	2.5	0.7	-0.5	0.0	-0.6	1.6	-0.4	-0.6
Liver weight, right	1.3	2.2	4.9	0.9	-1.4	2.2	-0.8	1.8	0.7	1.8
Locomotor activity	2.8	4.5	9.4	2.0	-2.6	3.1	-2.5	1.7	1.4	0.5
Locomotor testing distance	0.5	0.8	1.9	0.7	-1.1	1.4	-1.0	0.3	0.8	0.6
Locomotor testing rearing	1.1	1.7	4.6	0.9	-1.5	1.2	-1.2	0.8	2.1	0.6
Locomotion in novel chamber	1.5	1.8	6.9	-1.1	-0.3	1.4	0.8	-0.6	1.3	2.6
Locomotion in novel chamber post-restriction	0.1	0.2	0.7	-0.1	0.1	-0.7	0.2	-0.8	-0.0	-0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.7	0.2	-0.3	0.3	0.1	0.8	-0.2	-0.1
Change in fecal boli incidents, locomotor task	0.3	0.2	0.7	-0.7	0.2	0.3	0.2	0.1	0.6	0.8
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	-0.1	-0.4	0.0	-0.7	0.9	0.6	-0.7
Bouts of movement, locomotor time 1	0.4	0.5	1.2	1.1	-0.5	0.4	-0.7	0.7	0.3	-0.8
Total resting periods, locomotor time 1	0.4	0.4	1.7	0.8	-0.0	-0.2	-0.5	0.5	-0.3	-1.3
Rest time, locomotor task time 1	0.7	0.8	3.3	0.7	-0.8	0.7	-0.8	1.8	-0.2	-0.4
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	-0.3	0.0	0.1	0.1	-0.2	-0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.1	0.3	-0.7	-0.1	-0.5	0.2	-0.6
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.7	0.7	-0.2	-0.0	-1.3	0.5	0.3	-1.2
Bouts of movement, locomotor time 2	1.4	1.5	4.4	-0.8	1.3	-1.4	0.9	-0.3	-2.1	-1.0
Total resting periods, locomotor time 2	1.4	1.5	4.3	-0.9	1.3	-1.3	1.0	-0.1	-2.1	-0.9
Rest time, locomotor task time 2	1.8	2.0	4.6	-2.0	1.1	0.4	1.9	0.9	-0.0	2.2
Distance moved, locomotor task time 2	1.9	2.2	5.2	2.3	-1.9	0.8	-2.0	0.5	0.8	-1.2
Vertical activity count, locomotor time 2	2.4	2.6	6.3	2.3	-1.8	0.6	-2.5	0.6	0.5	-1.6
Light reinforcement 1	0.8	1.4	3.3	0.7	-1.4	1.8	-0.8	0.2	1.6	1.0
Light reinforcement 2	3.1	4.1	6.5	2.5	-2.2	2.4	-2.3	2.0	1.5	-0.3
Bone: marrow area	1.4	3.0	5.4	2.2	-2.3	1.7	-1.7	1.6	1.4	-0.7
Bone: maximum diameter	4.4	8.0	13.3	3.7	-3.3	2.7	-3.6	2.5	1.8	-1.6
Bone: maximum force	1.1	1.8	7.2	1.5	-0.8	-0.4	-1.4	0.6	-0.6	-2.7
Bone: maximum moment	1.3	2.2	8.6	1.6	-0.9	-0.4	-1.7	0.8	-0.4	-2.9
Mean time between licks in bursts	0.8	1.1	2.3	-1.5	0.9	-0.6	1.1	-1.3	0.5	1.1
Mean num. licks in bursts	0.9	1.1	2.1	1.5	-1.1	0.4	-1.2	0.9	0.7	-1.1
Cd content in liver	0.3	0.3	0.9	-0.2	0.7	-0.6	0.4	-0.5	-0.9	-0.4
Co content in liver	0.8	0.9	1.9	0.9	-1.1	1.4	-1.1	0.6	0.9	0.3
Cu content in liver	6.3	7.6	10.2	-3.1	3.2	-2.9	3.2	-3.1	-2.2	0.6
Fe content in liver	0.4	0.5	1.8	0.7	-0.3	0.3	-0.8	1.3	0.4	-0.5
K content in liver	0.8	0.8	3.0	0.3	0.5	-0.6	0.5	-0.5	-1.7	-1.1
Mg content in liver	1.0	1.0	3.5	0.3	0.7	-0.8	0.6	-0.6	-1.9	-1.2
Mn content in liver	1.1	1.3	3.0	1.2	-1.4	1.7	-1.1	0.6	0.8	0.7
Na content in liver	2.4	2.5	4.1	-1.8	2.0	-1.7	1.7	-1.5	-1.5	-0.1
Rb content in liver	1.2	1.5	4.4	-0.7	1.1	-1.5	0.6	-2.1	-0.8	-1.0
Se content in liver	0.1	0.2	0.7	0.1	0.0	0.5	0.5	-0.1	-0.1	0.8
Sr content in liver	1.1	1.0	3.2	-1.2	0.3	0.2	1.2	0.2	0.7	1.8
Zn content in liver	0.7	0.8	1.4	-1.1	0.8	-0.5	1.2	-1.0	0.0	0.9
Bone: minimum diameter	1.5	2.9	4.3	2.1	-2.0	2.0	-1.7	1.5	1.6	0.0
Time in familiar zone, hab. session 1	0.9	0.8	2.1	1.0	-1.1	0.7	-0.8	1.5	0.6	-0.4
Time in novel zone, hab. session 1	0.5	0.5	2.6	-0.4	0.3	-0.4	-0.2	-1.6	0.5	-0.1
Total zone transitions, hab. session 1	1.8	2.5	5.0	-1.9	1.7	-1.5	1.7	-2.2	-0.8	0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.9	-0.3	-0.1	0.2	0.2	-0.5	-0.1	1.0
Locomotion velocity, hab. session 1	0.2	0.2	1.2	-0.3	-0.2	0.4	0.1	0.1	-0.1	1.1
Time in familiar zone, hab. session 2	0.8	0.8	3.1	0.4	-0.4	0.8	-0.5	-0.6	1.8	0.9
Time in novel zone, hab. session 2	0.8	0.8	2.1	-0.9	0.8	-0.9	0.7	-0.3	-1.4	-0.5
Total zone transitions, hab. session 2	0.2	0.3	1.1	0.4	-0.1	-0.5	-0.4	0.3	-0.3	-1.1
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.4	-0.3	0.2	-0.7	0.6	0.0	-0.2
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.4	-0.3	0.2	-0.6	0.7	-0.0	-0.2
Novel to familiar place preference ratio	0.6	0.6	2.0	-1.1	0.3	-0.6	0.2	-0.7	1.4	0.4
Novelty place preference	0.7	0.7	3.1	-0.9	-0.1	-0.3	-0.1	-0.6	1.8	0.6
Time in novel zone, NPP test	0.9	0.9	4.4	-1.0	-0.1	-0.4	-0.1	-0.7	2.1	0.6
Total zone transitions, NPP test	0.8	1.1	1.9	-1.2	1.3	-1.4	1.4	-0.6	-0.7	0.3
Total locomotion distance, NPP test	0.2	0.2	0.7	-0.3	0.4	-0.4	0.5	0.8	-0.4	0.3
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.3	0.4	-0.3	0.7	0.7	-0.6	0.5
Intraocular pressure	0.9	1.3	2.9	0.8	-1.0	1.7	-0.1	1.5	0.5	1.3
Delta distance traveled before/after self-admin	0.4	0.4	0.9	0.5	-0.7	0.5	-0.9	0.4	0.9	-0.2
Delta ambulatory time before/after self-admin	0.3	0.3	0.8	0.5	-0.5	0.3	-0.9	-0.3	0.8	-0.5
Parametrial fat weight	0.7	1.3	5.0	-0.8	0.3	0.5	0.8	2.2	-0.3	1.5
Pavlov. Cond. lever latency	1.1	1.4	2.9	-1.0	0.8	-1.7	0.9	-1.7	-1.1	-0.8
Pavlov. Cond. magazine entry latency	0.2	0.2	1.0	0.1	0.6	0.1	-0.3	1.0	0.2	-0.2
Pavlov. Cond. change in total contacts	0.5	0.5	1.5	0.7	0.1	0.8	-0.8	1.2	-0.2	-0.6
Pavlov. Cond. index score	0.5	0.7	2.7	0.8	-0.1	0.9	-0.7	1.6	0.2	-0.0
Pavlov. Cond. latency score	0.6	0.8	2.4	0.9	-0.4	1.1	-0.9	1.5	0.5	0.0
Pavlov. Cond. lever contacts	1.9	2.2	5.1	1.4	-1.1	2.3	-1.2	1.9	1.2	1.0
Pavlov. Cond. magazine entry number	0.2	0.3	1.1	-0.5	-0.4	-0.4	0.4	-1.0	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.1	-0.8	1.2	-0.7	1.2	-1.2	-1.5	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	2.5	0.6	0.0	0.9	-0.5	1.6	0.1	0.2
Pavlov. Cond. response bias	1.0	1.2	3.3	1.1	-0.3	1.5	-0.8	1.8	0.6	0.4
Pavlov. Cond. lever latency	0.3	0.4	1.5	-0.6	0.5	-0.2	0.4	-1.2	-0.7	0.5
Pavlov. Cond. magazine entry latency	1.8	2.1	5.0	-1.0	1.7	-2.2	1.2	-0.5	-1.2	-1.7
Pavlov. Cond. change in total contacts	0.8	1.1	4.1	0.3	0.3	-0.7	-0.3	1.7	-0.5	-2.0
Pavlov. Cond. index score	0.4	0.5	1.8	-0.1	0.6	-1.0	0.3	0.5	-0.3	-1.3
Pavlov. Cond. latency score	0.5	0.6	2.4	0.0	0.5	-1.1	0.3	0.5	-0.5	-1.6
Pavlov. Cond. lever contacts	0.4	0.6	1.7	0.8	-0.4	-0.2	-0.5	1.0	0.3	-1.3
Pavlov. Cond. magazine entry number	0.7	0.8	2.2	0.7	-0.9	1.5	-0.7	0.4	0.5	1.2
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.7	1.3	-0.5	0.2	-0.9	0.9	-1.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	-0.2	0.6	-1.0	0.5	0.5	-0.3	-1.1
Pavlov. Cond. response bias	0.3	0.4	1.9	0.2	0.2	-0.7	-0.1	0.6	-0.1	-1.4
Time in closed arm before self-admin	0.6	0.6	1.4	-0.2	1.2	-1.2	0.7	-0.6	-0.7	-0.7
Time in closed arm after self-admin	0.2	0.2	1.0	0.1	0.1	-0.0	-0.3	-1.0	0.1	-0.2
Time in open arm before self-admin	0.5	0.5	1.5	-1.0	-0.1	0.5	0.8	0.7	-0.2	1.2
Time in open arm after self-admin	0.4	0.4	0.8	-0.9	-0.0	-0.2	0.8	0.8	-0.5	0.8
Bone: periosteal estimation	1.6	3.4	5.8	2.4	-2.3	1.7	-2.2	1.4	1.2	-1.2
Bone: periosteal perimeter	3.6	6.0	8.7	2.9	-2.8	2.8	-2.9	2.2	2.1	-0.4
Bone: post-yield work	0.8	1.2	2.3	-0.9	1.1	-1.5	0.9	-1.0	-0.8	-1.2
Progressive ratio test 1 active lever presses	1.6	1.6	4.8	1.2	-1.4	2.2	-0.1	-0.2	0.9	1.6
Progressive ratio test 1 breakpoint	1.5	1.5	4.5	1.2	-1.3	2.1	-0.0	-0.0	0.8	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.8	0.7	-0.9	0.7	-0.1	-0.5	-0.1	0.7
Progressive ratio test 2 active lever presses	0.3	0.4	1.6	1.3	-0.4	0.1	-0.0	0.5	-0.7	-0.2
Progressive ratio test 2 breakpoint	0.3	0.4	1.5	1.2	-0.4	0.1	-0.1	0.6	-0.7	-0.3
Progressive ratio test 2 inactive lever presses	0.7	0.8	3.8	1.9	-1.0	0.4	-0.7	0.1	-0.2	-0.5
Incentive Sensitization - Responses	0.7	0.8	1.5	1.1	-0.1	-0.6	-0.4	0.9	-1.0	-1.2
Incentive Sensitization - Breakpoint	0.8	0.8	1.5	1.2	-0.3	-0.5	-0.5	1.1	-1.0	-1.2
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.8	0.3	0.2	-0.9	-0.1	0.9	-0.7	-1.3
Progressive ratio	0.3	0.3	0.8	-0.6	0.5	-0.2	0.9	0.6	-0.1	0.5
Food seeking constrained by brief footshock	0.5	0.6	1.2	1.1	-0.8	0.4	-1.0	0.5	0.5	-0.8
Seeking ratio, punishment vs. effort	0.8	1.0	2.9	1.2	-0.6	-0.3	-1.2	-0.7	-0.1	-1.7
Retroperitoneal fat weight	1.9	6.2	9.4	3.1	-3.0	3.0	-2.7	2.7	1.1	-0.1
Reaction time number correct	0.2	0.3	0.6	-0.7	0.4	-0.2	0.6	0.8	-0.4	0.7
Reaction time mean minus median	0.3	0.4	1.2	-0.8	0.5	-0.1	0.5	1.1	0.2	0.6
Reaction time mean minus median AUC	0.5	0.7	2.8	-0.8	0.1	0.1	0.7	1.7	-0.1	0.9
Reaction time num false alarms	0.5	0.7	2.3	0.1	-0.4	1.2	0.1	-0.2	1.0	1.5
Reaction time num false alarms AUC	0.8	1.1	3.3	0.2	-0.5	1.4	0.1	-0.7	1.1	1.8
Reaction time trials correct on left	0.2	0.3	0.6	-0.7	0.4	-0.2	0.6	0.8	-0.4	0.7
Reaction time trials on left	0.2	0.3	0.5	-0.7	0.5	-0.2	0.6	0.7	-0.4	0.7
Reaction time mean	1.9	2.6	4.9	-1.6	2.0	-2.2	1.5	-1.0	-1.8	-0.5
Reaction time mean AUC	2.1	2.9	5.3	-1.8	2.0	-2.3	1.8	-1.1	-1.7	-0.3
Median of all reaction times	2.8	3.8	7.1	-1.7	2.3	-2.7	1.7	-1.7	-2.2	-0.9
Reaction time omissions	1.0	1.4	2.4	-1.4	1.6	-1.3	1.2	-1.2	-0.9	-0.2
Reaction time false alarm rate	0.6	0.9	1.9	0.6	-0.8	1.4	-0.3	-0.8	1.2	1.1
Reaction time premature initiation rate	0.9	1.2	5.4	0.7	-0.0	-0.7	-0.9	0.3	-1.1	-2.3
Reaction time premature initiations	0.6	0.8	2.9	0.2	0.3	-0.8	-0.5	0.6	-1.2	-1.7
Std. dev. reaction times	0.6	0.8	1.6	-1.2	1.1	-0.9	1.0	-0.2	-0.8	0.4
Reaction time trials completed	0.2	0.3	0.5	-0.7	0.5	-0.2	0.6	0.7	-0.4	0.7
Reaction time trials AUC	0.2	0.3	1.1	-0.4	0.3	-0.0	0.4	1.1	-0.4	0.5
Run reversals in cocaine runway, females	1.2	1.1	4.1	-0.5	0.1	0.8	0.3	-2.0	0.7	1.5
Run reversals in cocaine runway, males	1.3	1.3	2.4	0.3	-1.1	1.4	-0.3	1.1	1.5	1.6
Latency to leave start box in cocaine runway	1.2	1.3	2.9	1.7	-1.6	1.1	-1.3	0.5	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.6	0.6	1.2	1.0	-1.1	0.8	-0.9	-0.4	0.7	-0.1
Latency to leave start box in cocaine runway, M	1.6	1.5	3.5	1.9	-1.4	1.2	-1.2	1.4	-0.3	-0.7
Std. dev. time between licks in bursts	0.5	0.6	1.7	-0.3	0.6	-0.9	-0.2	0.3	-1.3	-1.0
Total sessions with >9 infusions	3.6	4.0	7.2	2.0	-2.3	2.5	-1.7	0.8	2.7	1.0
Short access day 1 total inactive lever presses	2.2	2.5	4.8	2.2	-2.1	1.5	-1.8	0.6	1.6	-0.4
Short access day 10 total inactive lever presses	2.2	2.5	13.0	0.8	-0.5	0.2	-1.0	3.6	-0.7	-1.4
Short access day 1 total infusions	2.7	2.9	6.9	1.5	-2.1	2.1	-1.2	0.4	2.6	1.0
Short access day 10 total infusions	2.9	3.2	6.5	2.4	-2.2	2.6	-1.6	0.8	1.5	0.6
Short access total infusions	4.2	4.7	8.0	2.8	-2.7	2.5	-2.2	1.1	2.2	0.2
Short access day 1 locomotion	0.3	0.3	1.1	0.6	-0.5	0.3	-0.3	0.1	1.1	0.0
Short access day 10 total locomotion	1.2	1.3	3.5	0.2	-1.0	1.6	0.2	-1.0	1.1	1.9
Short access total locomotion	1.3	1.4	2.7	1.6	-1.6	1.3	-1.1	0.2	1.2	0.2
One hour access (0.3 mA shock)	0.6	0.7	1.4	1.2	-1.1	1.0	-0.6	0.5	0.5	0.5
Compulsive drug intake	1.0	1.0	2.9	-1.0	1.0	-1.7	0.3	-0.7	-0.8	-1.0
One hour access (shock baseline)	1.8	2.1	4.4	2.0	-1.7	2.1	-0.9	0.5	1.3	1.0
Social response proportion	1.0	1.1	2.9	1.0	-1.2	0.8	-1.7	0.3	1.2	-0.5
Social responses	1.7	2.2	3.5	1.0	-1.8	1.9	-1.7	1.2	1.8	0.6
Social time	0.4	0.6	2.1	-0.5	0.2	0.8	0.4	-0.6	0.6	1.4
Soleus weight	0.2	0.6	1.2	1.1	-0.4	0.2	-1.0	0.7	-0.5	-1.1
Bone: stiffness	1.6	2.5	9.4	-0.0	1.0	-2.1	0.2	-0.6	-1.4	-3.1
Tibialis anterior weight	0.3	1.1	4.3	-0.9	0.6	-1.4	0.4	-2.1	0.0	-0.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.8	-0.6	0.1	0.3	0.8	-0.6	-0.1	0.9
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.6	0.7	-0.5	0.6	-0.2	-0.0	0.4	0.4
Time to tail flick, test, before self-admin	2.3	2.2	4.7	1.1	-1.6	2.0	-1.5	0.4	2.2	0.9
Time to tail flick, test, after self-admin	0.7	0.8	3.1	0.4	0.7	-0.7	-0.4	-1.8	0.2	-0.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.5	1.0	-0.4	-0.2	-0.8	0.9	-0.4	-1.2
Delta time to tail flick, test, before/after SA	3.0	2.7	5.1	-0.8	2.0	-2.3	1.1	-1.7	-2.0	-1.2
Tibia length	0.3	0.8	2.5	1.1	-0.4	0.7	-0.7	1.6	0.2	-0.6
Ambulatory time before self-admin	0.3	0.3	0.8	0.1	-0.6	0.5	0.2	0.5	0.7	0.9
Ambulatory time after self-admin	0.2	0.2	0.5	0.5	-0.2	-0.3	-0.6	-0.3	0.7	-0.5
Bone: tissue strength	1.2	1.2	2.5	-0.4	1.0	-1.5	0.6	0.2	-1.5	-1.6
Total heroin consumption	0.9	1.1	3.4	0.8	-0.0	-0.6	-0.0	1.1	-1.4	-1.8
Bone: trabecular number	0.5	0.8	1.6	-1.1	0.9	-0.3	1.3	-0.8	0.5	1.1
Bone: trabecular spacing	2.2	2.9	4.4	2.0	-2.1	1.4	-2.1	2.0	0.4	-1.2
Bone: trabecular thickness	0.2	0.2	0.8	-0.4	0.4	-0.0	0.5	-0.9	0.2	0.6
Bone: trabecular tissue density	1.2	1.7	3.6	-1.4	1.5	-1.9	1.2	-1.2	-0.7	-0.7
Water consumed over 24 hours	1.9	2.3	4.0	1.6	-1.8	1.5	-2.0	0.8	1.7	-0.7
Number of responses in last shaping day	0.2	0.2	0.5	-0.2	-0.3	0.5	-0.2	-0.7	0.7	0.3