Hub : Genes

Gtf2h4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Gtf2h4 0.18 0.09 8.6e-10 0.11 0.13 0.09 0.11 1.2e-06 1.5e-07 1.8e-05 1.9e-06
2 Brain gene expression Gtf2h4 0.15 0.07 6.2e-15 0.12 0.14 0.14 0.13 2.4e-11 3.5e-13 2.9e-13 1.9e-12
3 pVTA gene expression Gtf2h4 0.1 0.06 2.0e-04 0.08 0.04 0.07 0.07 2.2e-04 1.1e-02 5.7e-04 7.8e-04
4 PL gene expression Gtf2h4 0.16 0.09 2.7e-15 0.14 0.12 0.13 0.08 3.7e-15 1.2e-13 1.0e-13 5.4e-09
5 Liver gene expression Gtf2h4 0.35 0.13 0.0e+00 0.28 0.3 0.33 0.32 7.9e-31 7.5e-34 1.9e-37 3.4e-36
6 Adipose gene expression Gtf2h4 0.2 0.11 0.0e+00 0.15 0.17 0.17 0.17 5.3e-16 2.7e-18 5.5e-19 8.4e-19
7 NAcc gene expression Gtf2h4 0.09 0.05 6.3e-13 0.12 0.11 0.11 0.12 8.5e-14 4.0e-13 4.8e-13 1.5e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.13.64.8-2.02.01.61.72.22.11.7
Area under the delay curve1.92.02.91.3-1.4-1.3-1.6-1.4-1.7-1.1
BMI with tail1.65.16.81.9-2.6-2.4-2.4-1.9-1.8-2.6
BMI without tail3.87.98.82.7-3.0-2.9-2.9-2.7-2.6-2.9
Body weight6.929.134.05.4-5.7-5.8-5.6-4.9-4.7-5.6
Weight adjusted by age4.04.55.32.2-2.2-1.9-2.1-2.3-2.1-2.1
Bone surface0.20.30.60.8-0.3-0.6-0.5-0.6-0.7-0.5
Bone volume0.00.00.10.1-0.0-0.3-0.30.1-0.0-0.3
Breakpoint value in progressive ratio session0.91.01.9-0.91.10.91.30.70.61.4
Number of licking bursts0.10.10.30.20.30.50.4-0.4-0.40.4
Context. condit. distance diff. score3.74.56.6-1.42.52.52.61.41.32.5
Locomotion velocity, session 10.10.10.1-0.10.30.20.40.20.20.3
Locomotion distance, session 10.70.91.2-1.10.90.80.81.11.10.8
Locomotion velocity, session 20.00.00.10.30.1-0.20.0-0.3-0.3-0.0
Locomotion distance, session 20.40.61.0-0.71.00.70.80.80.80.7
Locomotion velocity, session 30.10.10.2-0.3-0.1-0.2-0.10.40.5-0.1
Locomotion distance, session 32.02.12.7-1.41.61.31.41.51.51.5
Stereotopy head waving bouts, day 32.52.93.81.9-1.6-1.5-1.6-1.8-1.8-1.6
Stereotopy head waving duration, day 31.82.12.41.5-1.5-1.3-1.4-1.5-1.5-1.4
Locomotion velocity, session 74.85.26.7-2.12.62.42.42.12.12.4
Locomotion distance, session 74.65.97.9-2.32.82.52.52.22.12.5
Stereotopy head waving bouts, day 72.12.43.01.5-1.7-1.7-1.7-1.2-1.3-1.7
Stereotopy head waving duration, day 73.03.64.31.9-2.1-2.0-2.0-1.6-1.6-2.0
Locomotion velocity, session 80.60.71.81.3-0.2-0.3-0.1-1.2-1.3-0.2
Locomotion distance, session 82.33.35.3-1.22.32.12.11.31.22.1
Degree of sensitization distance0.20.20.4-0.00.40.60.5-0.3-0.40.5
Degree of sensitization stereotypy1.31.41.71.1-1.2-1.3-1.3-0.9-1.0-1.3
Conditioned locomotion0.91.11.31.1-0.9-1.0-1.0-1.1-1.1-1.0
Cocaine response after cond. corrected0.50.50.8-0.70.80.90.80.40.40.9
Cocaine response after cond. not corrected0.50.51.30.8-0.5-0.3-0.4-1.0-1.1-0.3
Cocaine response before conditioning6.67.99.13.0-2.9-2.6-2.7-2.9-2.9-2.7
Saline control response0.50.71.50.2-1.1-1.1-1.1-0.00.1-1.2
Bone: connectivity density3.04.85.7-2.12.42.02.22.32.12.2
Bone: cortical apparent density0.10.20.3-0.3-0.5-0.4-0.60.10.2-0.5
Bone: cortical area2.43.64.21.9-1.7-2.0-2.0-1.8-1.8-2.0
Bone: cortical porosity0.40.40.60.4-0.8-0.6-0.8-0.6-0.6-0.8
Bone: cortical porosity0.91.01.31.1-1.0-0.8-1.0-1.1-1.2-1.0
Bone: cortical thickness1.72.84.81.0-1.7-2.1-2.2-1.0-1.0-2.1
Bone: cortical thickness0.20.20.4-0.3-0.4-0.6-0.60.20.4-0.5
Bone: cortical tissue density0.10.10.3-0.3-0.4-0.4-0.50.10.2-0.4
Condit. Reinf. active minus inactive responses0.80.91.4-0.91.21.01.00.80.81.0
Condit. Reinf. active-inactive response ratio0.00.00.0-0.20.1-0.10.00.0-0.0-0.0
Condit. Reinf. active responses1.51.92.5-1.31.61.51.31.31.31.4
Condit. Reinf. inactive responses3.13.74.6-2.02.01.81.72.02.11.8
Incentive salience index mean1.01.22.4-0.61.51.31.30.70.61.2
Condit. Reinf. lever presses1.72.23.9-0.82.01.91.70.90.81.7
Condit. Reinf. active minus inactive responses1.72.12.61.4-1.5-1.2-1.4-1.6-1.6-1.4
Condit. Reinf. active-inactive response ratio3.84.05.02.1-2.0-1.7-1.9-2.2-2.2-1.9
Condit. Reinf. active responses0.00.00.10.0-0.10.10.0-0.2-0.20.0
Condit. Reinf. inactive responses2.02.53.2-1.71.51.31.61.61.81.5
Condit. Reinf. lever presses0.40.61.0-0.80.71.00.90.40.50.7
Condit. Reinf. lever reinforcers received0.00.00.1-0.10.10.30.2-0.2-0.10.1
Conditioned reinforcement - actives0.70.71.30.6-0.6-0.7-0.9-1.1-1.2-0.8
Conditioned reinforcement - inactives1.11.32.40.7-1.0-1.1-1.6-1.0-1.1-1.2
Conditioned locomotion0.10.20.40.3-0.2-0.5-0.4-0.5-0.7-0.1
Patch foraging indifference point 0 sec0.20.30.7-0.4-0.5-0.5-0.90.30.4-0.7
Patch foraging indifference point AUC2.73.13.81.8-1.8-1.6-1.7-1.7-1.7-2.0
Delay disc. indifference point, 0s delay0.70.82.01.0-0.6-0.7-0.7-1.1-1.4-0.3
Delay disc. indifference point, 16s delay0.50.51.60.3-0.8-0.5-1.3-0.6-0.7-0.4
Delay disc. indifference point, 2s delay3.23.65.21.9-1.8-1.7-1.7-2.1-2.3-1.7
Delay disc. indifference point, 24s delay0.40.40.60.3-0.7-0.7-0.7-0.7-0.7-0.5
Delay disc. indifference point, 4s delay3.84.05.22.1-1.9-2.1-2.0-2.1-2.3-1.4
Delay disc. indifference point, 8s delay0.30.30.50.5-0.4-0.5-0.7-0.5-0.7-0.3
Indifference point function ln k0.20.30.6-0.30.70.60.80.30.30.6
Indifference point function log k0.20.30.6-0.30.70.60.80.30.30.6
Patch foraging total patch changes 0 sec0.20.41.0-0.3-0.6-0.6-1.00.20.3-0.8
Patch foraging total patch changes 12 sec0.40.51.3-0.0-0.8-0.6-1.1-0.2-0.2-0.9
Patch foraging total patch changes 18 sec0.40.61.4-1.10.10.1-0.11.11.2-0.2
Patch foraging total patch changes 24 sec1.31.63.7-1.91.00.90.61.61.60.6
Patch foraging total patch changes 6 sec0.20.30.6-0.5-0.5-0.4-0.70.20.4-0.8
Patch foraging time to switch 0 sec0.60.91.8-1.30.70.70.51.11.20.7
Patch foraging water rate 0 sec0.30.50.70.7-0.8-0.7-0.6-0.6-0.6-0.8
Patch foraging water rate 12 sec0.30.51.0-0.70.60.30.70.81.00.4
Patch foraging water rate 18 sec0.20.20.50.6-0.3-0.6-0.7-0.4-0.4-0.2
Patch foraging water rate 24 sec1.31.82.11.4-1.4-1.5-1.3-1.3-1.2-1.4
Patch foraging water rate 6 sec0.10.20.4-0.30.2-0.00.40.60.70.1
Seeking ratio, delayed vs. immediate footshock0.50.60.70.7-0.8-0.8-0.8-0.7-0.6-0.7
Distance traveled before self-admin0.00.00.10.40.0-0.0-0.1-0.2-0.3-0.1
Distance traveled after self-admin0.30.30.60.7-0.7-0.3-0.1-0.7-0.5-0.4
Extensor digitorum longus weight0.10.51.20.9-0.4-0.4-0.5-1.0-1.1-0.5
Bone: elastic displacement0.10.10.3-0.2-0.2-0.5-0.20.50.5-0.2
Bone: elastic work1.72.23.31.2-1.6-1.8-1.7-1.0-1.1-1.6
Bone: endosteal estimation4.18.913.03.6-2.7-2.5-2.3-3.5-3.4-2.4
Bone: endosteal perimeter0.91.83.91.9-0.8-0.6-0.4-2.0-2.0-0.5
Epididymis fat weight0.41.01.7-1.0-1.3-0.9-1.30.60.8-1.1
Delta time in closed arm before/after self-admin0.30.30.50.4-0.7-0.4-0.4-0.7-0.5-0.1
Delta time in open arm before/after self-admin0.00.00.1-0.10.1-0.2-0.10.30.2-0.3
Diff in mean of infusions in LGA sessions3.63.95.8-2.12.41.81.81.91.62.1
Delay discount exponential model param1.92.02.8-1.31.41.41.61.41.71.1
Extinction: sum of active levers before priming0.50.41.0-0.90.71.00.50.20.20.7
Active lever presses in extinction session 60.20.20.4-0.60.10.60.40.50.60.3
Bone: final force5.38.510.72.6-3.1-3.2-3.3-2.4-2.4-3.3
Bone: final moment4.87.89.82.5-3.0-3.1-3.1-2.3-2.3-3.1
Food consumed during 24 hour testing period1.01.31.91.4-1.0-1.2-1.1-1.1-1.0-1.1
Glucose0.60.82.11.00.30.60.4-1.3-1.40.6
Heart weight0.20.30.70.6-0.7-0.3-0.3-0.8-0.8-0.3
Delay discount hyperbolic model param2.22.33.3-1.41.51.51.61.61.81.2
Intermittent access intake day 1-15 change0.80.82.80.8-0.6-1.7-1.1-0.2-0.2-0.9
Intermittent access intake escalation0.50.51.90.8-0.3-1.4-0.8-0.2-0.2-0.5
Intermittent access intake escalation 20.30.31.21.1-0.0-0.8-0.4-0.4-0.4-0.1
Intermitt. access day 1 inactive lever presses0.40.50.90.9-0.7-0.3-0.4-0.8-1.0-0.3
Intermitt. access day 15 inactive lever presses2.52.74.41.5-1.8-1.3-1.8-1.5-1.5-2.1
Intermitt. access escalation Index3.22.83.4-1.61.81.81.61.71.51.8
Intermittent access day 1 total infusions0.40.40.8-0.80.90.60.60.60.40.7
Intermittent access day 15 total infusions0.10.10.4-0.30.5-0.60.00.40.30.1
Intermittent access terminal intake (last 3 days)0.10.20.50.1-0.1-0.7-0.5-0.2-0.3-0.3
Intermittent access total infusions0.00.00.1-0.30.3-0.30.00.10.0-0.1
Intermittent access day 1 locomotion0.10.10.2-0.20.5-0.30.10.1-0.10.5
Intermittent access day 15 total locomotion1.21.32.91.3-0.8-1.7-1.2-0.9-1.0-0.8
Intermittent access total locomotion0.80.92.61.0-0.6-1.6-1.0-0.7-0.7-0.7
Intermittent access standard deviation2.32.44.11.2-1.7-2.0-1.9-1.2-1.2-1.5
Left kidney weight4.211.914.73.3-3.6-3.8-3.7-2.9-2.8-3.8
Right kidney weight4.011.213.33.4-3.4-3.6-3.6-3.0-2.9-3.4
Cocaine induced anxiety1.82.03.2-0.91.71.51.81.31.31.3
Post-drug Anxiety0.70.71.6-0.50.81.31.30.50.70.5
Baseline Anxiety0.10.10.2-0.3-0.50.4-0.2-0.4-0.4-0.2
Tail length6.419.326.45.1-4.2-4.4-4.1-4.5-4.5-3.8
Length with tail5.520.326.05.1-4.4-4.7-4.4-4.4-4.2-4.2
Length without tail3.98.59.83.1-2.9-3.0-2.9-2.8-2.7-2.9
Times rat made contact with spout2.73.14.9-2.01.51.31.32.22.21.4
Lifetime Intake0.00.00.1-0.10.2-0.2-0.1-0.2-0.3-0.2
Liver weight, left0.81.22.01.4-0.9-1.1-1.1-1.1-1.1-0.9
Liver weight, right5.08.412.13.5-2.7-2.7-2.6-3.0-3.0-2.6
Locomotor activity2.13.34.72.2-1.6-1.8-1.7-2.0-1.9-1.5
Locomotor testing distance0.40.60.90.8-0.7-0.7-0.8-0.9-0.9-0.7
Locomotor testing rearing0.91.41.71.3-1.1-1.2-1.2-1.2-1.2-1.1
Locomotion in novel chamber0.60.81.30.9-0.8-1.1-1.0-0.5-0.7-0.8
Locomotion in novel chamber post-restriction0.40.40.80.6-0.9-0.8-0.7-0.6-0.5-0.5
Fecal boli incidents, locomotor time 10.80.91.3-1.00.81.11.10.90.90.6
Change in fecal boli incidents, locomotor task1.31.32.31.1-1.0-0.9-0.9-1.5-1.5-0.8
Time >=10cm from walls, locomotor time 11.11.21.81.2-1.2-0.6-0.7-1.3-1.0-1.3
Bouts of movement, locomotor time 11.11.22.6-0.61.30.91.21.00.91.6
Total resting periods, locomotor time 10.50.61.8-0.20.90.50.80.60.51.4
Rest time, locomotor task time 10.10.10.40.6-0.2-0.50.2-0.00.2-0.1
Distance moved, locomotor task time 10.40.50.80.4-0.8-0.4-0.9-0.7-0.8-0.7
Vertical activity count, locomotor time 10.20.20.60.1-0.6-0.3-0.7-0.2-0.4-0.7
Time >=10cm from walls, locomotor time 20.40.40.70.5-0.7-0.5-0.2-0.8-0.8-0.7
Bouts of movement, locomotor time 21.21.32.81.4-0.8-1.7-1.0-0.9-1.0-0.9
Total resting periods, locomotor time 20.91.02.01.4-0.6-1.4-0.7-0.8-1.0-0.6
Rest time, locomotor task time 20.10.10.70.90.1-0.20.2-0.1-0.20.2
Distance moved, locomotor task time 20.20.20.5-0.1-0.7-0.3-0.7-0.4-0.4-0.5
Vertical activity count, locomotor time 20.00.00.2-0.4-0.20.1-0.0-0.00.10.0
Light reinforcement 10.00.10.1-0.2-0.3-0.3-0.10.20.4-0.3
Light reinforcement 20.60.91.51.1-1.0-1.2-1.0-0.5-0.5-0.8
Bone: marrow area4.18.812.83.6-2.7-2.6-2.3-3.5-3.4-2.4
Bone: maximum diameter1.32.34.12.0-1.0-1.1-1.1-1.9-2.0-1.1
Bone: maximum force4.78.110.22.6-2.9-3.2-3.2-2.3-2.3-3.2
Bone: maximum moment4.47.69.82.6-2.8-3.1-3.1-2.3-2.3-3.0
Mean time between licks in bursts0.30.41.11.0-0.00.00.1-0.9-1.00.0
Mean num. licks in bursts0.70.92.4-1.10.40.10.31.51.60.3
Cd content in liver0.20.20.40.0-0.4-0.6-0.60.10.2-0.6
Co content in liver0.70.91.60.4-1.3-0.9-1.2-0.7-0.5-1.1
Cu content in liver4.96.07.7-2.72.32.32.22.72.82.0
Fe content in liver0.30.30.70.0-0.7-0.8-0.60.10.2-0.7
K content in liver0.20.20.6-0.30.40.80.4-0.1-0.10.5
Mg content in liver1.31.42.7-0.61.41.71.50.30.21.5
Mn content in liver0.50.60.80.60.60.80.8-0.8-0.90.8
Na content in liver0.00.00.00.10.0-0.0-0.2-0.1-0.2-0.2
Rb content in liver1.11.31.7-1.11.11.31.21.01.11.2
Se content in liver0.30.40.60.50.70.50.8-0.5-0.60.7
Sr content in liver1.11.01.71.2-0.9-0.8-0.8-1.2-1.3-0.8
Zn content in liver0.10.10.20.2-0.00.1-0.0-0.4-0.50.0
Bone: minimum diameter1.62.95.02.2-1.2-1.3-1.1-2.2-2.2-1.2
Time in familiar zone, hab. session 15.24.86.4-2.52.11.92.02.42.52.0
Time in novel zone, hab. session 12.82.73.61.9-1.7-1.4-1.4-1.8-1.8-1.4
Total zone transitions, hab. session 10.71.01.2-1.01.11.11.00.90.91.0
Total locomotion distance, hab. session 10.60.91.2-1.01.10.90.90.80.80.9
Locomotion velocity, hab. session 10.30.40.6-0.70.80.60.60.50.50.6
Time in familiar zone, hab. session 20.50.50.8-0.80.60.90.60.70.70.6
Time in novel zone, hab. session 20.40.41.00.6-0.7-1.0-0.6-0.3-0.2-0.6
Total zone transitions, hab. session 20.00.00.1-0.30.20.10.10.20.20.1
Total locomotion distance, hab. session 21.31.72.0-1.31.41.21.31.31.21.3
Locomotion velocity, hab. session 21.31.82.3-1.31.51.31.41.31.11.4
Novel to familiar place preference ratio0.00.00.1-0.20.10.1-0.00.30.3-0.0
Novelty place preference0.00.00.10.1-0.1-0.2-0.30.0-0.0-0.3
Time in novel zone, NPP test0.10.10.20.3-0.3-0.4-0.4-0.1-0.2-0.4
Total zone transitions, NPP test1.31.92.4-1.31.61.21.41.41.41.4
Total locomotion distance, NPP test1.62.12.7-1.51.61.21.41.61.51.4
Locomotion velocity, NPP test2.63.64.5-1.92.11.61.82.01.91.9
Intraocular pressure1.62.23.5-1.31.51.11.61.71.91.2
Delta distance traveled before/after self-admin0.91.01.50.9-1.2-1.1-1.0-0.9-0.8-1.1
Delta ambulatory time before/after self-admin0.50.60.80.8-0.9-0.9-0.6-0.7-0.7-0.8
Parametrial fat weight1.93.75.31.7-2.0-2.3-2.3-1.4-1.3-2.2
Pavlov. Cond. lever latency0.40.50.9-0.4-0.9-0.9-0.60.40.5-0.7
Pavlov. Cond. magazine entry latency0.30.40.80.10.90.80.8-0.0-0.10.9
Pavlov. Cond. change in total contacts1.21.32.31.5-0.6-0.7-0.8-1.5-1.5-0.8
Pavlov. Cond. index score0.40.51.10.31.00.90.8-0.3-0.40.9
Pavlov. Cond. latency score0.30.40.60.60.80.70.5-0.6-0.70.5
Pavlov. Cond. lever contacts0.40.41.00.90.50.50.2-0.8-1.00.2
Pavlov. Cond. magazine entry number0.81.01.70.5-1.3-1.2-1.3-0.3-0.4-1.3
Pavlov. Cond. intertrial magazine entries1.21.42.5-1.50.80.70.91.61.60.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.40.21.21.00.9-0.2-0.21.0
Pavlov. Cond. response bias0.60.71.5-0.01.21.11.1-0.0-0.01.1
Pavlov. Cond. lever latency0.40.50.60.8-0.6-0.8-0.7-0.7-0.8-0.6
Pavlov. Cond. magazine entry latency0.80.91.21.1-0.9-0.7-1.0-1.0-1.1-1.0
Pavlov. Cond. change in total contacts0.10.10.30.1-0.4-0.2-0.4-0.1-0.1-0.5
Pavlov. Cond. index score0.00.00.00.0-0.00.1-0.1-0.0-0.0-0.2
Pavlov. Cond. latency score0.00.10.10.2-0.3-0.0-0.3-0.2-0.2-0.4
Pavlov. Cond. lever contacts0.40.51.0-0.80.50.60.50.91.00.3
Pavlov. Cond. magazine entry number0.30.40.6-0.60.60.50.70.40.50.7
Pavlov. Cond. intertrial magazine entries0.60.81.7-0.41.10.91.30.30.41.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.0-0.10.1-0.1-0.0-0.0-0.2
Pavlov. Cond. response bias0.20.20.4-0.50.40.50.30.70.60.2
Time in closed arm before self-admin0.00.10.1-0.20.10.30.40.20.2-0.1
Time in closed arm after self-admin0.40.40.70.5-0.8-0.5-0.9-0.5-0.3-0.7
Time in open arm before self-admin0.10.10.50.10.60.1-0.10.20.00.7
Time in open arm after self-admin0.40.50.9-0.61.00.60.50.70.40.9
Bone: periosteal estimation4.28.610.83.3-2.7-2.8-2.6-3.2-3.2-2.6
Bone: periosteal perimeter2.23.65.32.3-1.5-1.6-1.5-2.2-2.3-1.5
Bone: post-yield work0.10.10.50.7-0.1-0.2-0.1-0.5-0.4-0.0
Progressive ratio test 1 active lever presses0.10.10.2-0.40.4-0.00.30.1-0.10.3
Progressive ratio test 1 breakpoint0.10.10.2-0.40.40.00.2-0.0-0.10.3
Progressive ratio test 1 inactive lever presses0.10.10.3-0.60.20.2-0.00.20.10.1
Progressive ratio test 2 active lever presses0.70.71.1-1.01.10.31.00.90.80.7
Progressive ratio test 2 breakpoint1.21.42.0-1.31.40.61.31.21.20.9
Progressive ratio test 2 inactive lever presses0.50.50.90.7-0.4-0.8-0.8-0.6-0.7-1.0
Incentive Sensitization - Responses0.70.81.0-0.91.00.41.01.00.90.7
Incentive Sensitization - Breakpoint1.01.01.3-0.91.10.51.11.11.10.9
Sum of active levers in priming session hrs 5-60.30.30.6-0.70.50.70.30.40.30.6
Progressive ratio4.85.58.32.0-2.5-2.9-2.5-1.8-1.8-2.6
Food seeking constrained by brief footshock0.00.00.0-0.20.00.2-0.10.00.1-0.0
Seeking ratio, punishment vs. effort4.04.97.9-2.02.32.82.41.61.72.4
Retroperitoneal fat weight0.31.12.00.9-1.1-1.2-1.4-0.9-0.9-0.9
Reaction time number correct0.10.10.4-0.6-0.20.1-0.10.40.5-0.0
Reaction time mean minus median0.20.31.41.20.2-0.5-0.3-0.3-0.50.1
Reaction time mean minus median AUC0.10.10.60.80.4-0.10.1-0.1-0.30.3
Reaction time num false alarms0.50.71.11.0-0.7-0.7-0.7-0.9-1.0-0.7
Reaction time num false alarms AUC0.91.32.01.3-1.0-0.9-1.0-1.3-1.4-0.9
Reaction time trials correct on left0.10.10.4-0.6-0.20.1-0.10.40.5-0.0
Reaction time trials on left0.10.10.3-0.5-0.20.0-0.20.30.4-0.1
Reaction time mean0.20.20.50.70.70.20.4-0.1-0.40.6
Reaction time mean AUC0.20.20.50.70.60.10.3-0.1-0.30.6
Median of all reaction times0.20.20.40.50.60.30.5-0.1-0.20.6
Reaction time omissions0.20.20.60.80.40.00.2-0.4-0.60.4
Reaction time false alarm rate0.91.32.51.4-0.8-0.7-0.8-1.4-1.6-0.7
Reaction time premature initiation rate1.41.92.81.2-1.4-1.4-1.2-1.3-1.3-1.7
Reaction time premature initiations1.31.83.01.0-1.5-1.4-1.4-1.2-1.1-1.7
Std. dev. reaction times0.40.51.91.40.0-0.5-0.4-0.7-0.90.0
Reaction time trials completed0.10.10.3-0.5-0.20.0-0.20.30.4-0.1
Reaction time trials AUC0.10.10.4-0.6-0.10.1-0.10.40.50.0
Run reversals in cocaine runway, females0.10.10.2-0.50.20.2-0.10.50.4-0.0
Run reversals in cocaine runway, males1.41.42.51.6-0.8-1.1-1.2-1.0-1.2-1.2
Latency to leave start box in cocaine runway0.20.20.50.4-0.2-0.0-0.5-0.6-0.7-0.7
Latency to leave start box in cocaine runway, F0.10.10.6-0.20.60.80.3-0.1-0.10.0
Latency to leave start box in cocaine runway, M1.00.91.60.9-1.0-0.9-1.3-0.7-0.7-1.1
Std. dev. time between licks in bursts0.91.12.71.3-0.5-0.1-0.4-1.5-1.6-0.3
Total sessions with >9 infusions0.20.20.70.2-0.0-0.3-0.3-0.6-0.8-0.3
Short access day 1 total inactive lever presses0.60.71.61.1-0.3-0.5-0.6-1.0-1.3-0.4
Short access day 10 total inactive lever presses0.10.10.20.5-0.10.1-0.2-0.1-0.30.1
Short access day 1 total infusions0.10.20.3-0.40.50.50.3-0.1-0.30.4
Short access day 10 total infusions0.20.20.50.3-0.1-0.2-0.3-0.7-0.7-0.4
Short access total infusions0.20.30.80.3-0.2-0.2-0.4-0.8-0.9-0.4
Short access day 1 locomotion2.93.14.4-1.62.11.92.11.21.21.9
Short access day 10 total locomotion0.60.71.70.9-0.5-0.2-0.3-1.3-1.30.0
Short access total locomotion0.10.10.4-0.00.20.30.2-0.5-0.60.3
One hour access (0.3 mA shock)0.50.61.6-0.61.30.60.50.70.40.9
Compulsive drug intake2.82.94.5-1.41.82.12.01.21.02.0
One hour access (shock baseline)0.70.81.50.8-0.6-1.2-1.1-0.5-0.5-1.0
Social response proportion0.40.40.90.6-0.5-0.3-0.5-0.9-0.9-0.1
Social responses0.40.51.00.6-0.7-0.4-0.5-1.0-0.9-0.2
Social time0.91.12.61.5-0.5-0.6-0.5-1.5-1.6-0.4
Soleus weight1.23.67.52.5-1.2-1.1-1.0-2.6-2.7-1.0
Bone: stiffness0.91.32.00.9-1.2-1.3-1.4-0.8-0.8-1.4
Tibialis anterior weight0.10.20.5-0.70.30.20.00.60.6-0.1
Time to tail flick, vehicle, before self-admin0.10.10.10.00.30.00.30.20.3-0.2
Time to tail flick, vehicle, after self-admin0.40.40.7-0.10.70.60.90.60.40.6
Time to tail flick, test, before self-admin0.00.00.1-0.0-0.0-0.1-0.20.20.2-0.3
Time to tail flick, test, after self-admin0.90.91.8-0.51.20.30.71.31.01.2
Delta time to tail flick, vehicle, before/after SA0.80.81.1-0.70.80.81.01.00.80.9
Delta time to tail flick, test, before/after SA1.31.21.8-1.01.20.60.91.31.31.2
Tibia length3.710.413.33.7-3.2-3.1-2.7-3.6-3.4-2.8
Ambulatory time before self-admin0.00.00.10.20.00.1-0.40.1-0.10.1
Ambulatory time after self-admin0.10.20.30.6-0.5-0.2-0.2-0.4-0.3-0.4
Bone: tissue strength3.93.85.11.8-2.1-2.1-2.2-1.5-1.6-2.3
Total heroin consumption0.00.00.1-0.10.20.1-0.40.30.10.1
Bone: trabecular number2.54.06.0-2.02.11.51.72.52.31.7
Bone: trabecular spacing5.47.08.42.7-2.8-2.2-2.6-2.9-2.8-2.6
Bone: trabecular thickness1.92.33.2-1.61.51.11.41.81.81.3
Bone: trabecular tissue density1.92.73.01.6-1.7-1.6-1.6-1.6-1.5-1.7
Water consumed over 24 hours0.00.10.20.3-0.20.0-0.1-0.4-0.4-0.1
Number of responses in last shaping day0.80.82.00.8-0.6-0.6-0.5-1.3-1.4-0.7