Hub : Genes

Grsf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Grsf1 0.11 0.05 1.4e-14 0.12 0.12 0.12 0.12 5.0e-13 5.9e-13 2.1e-13 3.1e-13
2 Liver gene expression Grsf1 0.1 0.06 4.1e-08 0.05 0.06 0.07 0.06 2.2e-06 4.8e-07 2.0e-08 2.3e-07
3 pVTA gene expression Grsf1 0.1 0.06 5.0e-06 0.08 0.04 0.06 0.07 7.3e-07 4.0e-04 1.4e-05 2.6e-06
4 pVTA mRNA stability Grsf1 0.03 0.02 5.4e-03 0.01 0.02 0.02 0.01 3.6e-02 1.6e-02 1.1e-02 4.9e-02
5 Brain gene expression Grsf1 0.16 0.07 1.2e-08 0.06 0.1 0.1 0.09 1.2e-06 3.9e-09 2.6e-09 2.1e-08
6 BLA gene expression Grsf1 0.05 0.04 8.6e-03 0.04 0.04 0.03 0.03 5.4e-03 5.9e-03 8.8e-03 1.3e-02
7 NAcc gene expression Grsf1 0.09 0.05 1.5e-08 0.02 0.05 0.05 0.05 6.8e-04 1.1e-08 1.9e-08 1.8e-08
8 Brain mRNA stability Grsf1 0.08 0.06 8.3e-03 0.01 0.02 0.02 0.03 1.4e-02 2.6e-03 7.6e-03 7.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.30.50.8-0.70.00.8-0.80.20.9-0.60.9
Area under the delay curve0.20.30.8-0.1-0.2-0.40.9-0.7-0.7-0.6-0.0
BMI with tail1.13.911.6-3.4-2.32.1-0.91.52.21.3-0.6
BMI without tail0.92.98.2-2.9-2.41.8-0.71.21.90.50.3
Body weight0.20.92.7-1.3-0.80.40.2-0.5-0.1-1.61.1
Weight adjusted by age0.40.71.6-0.6-0.40.7-1.31.00.60.31.1
Bone surface0.40.82.1-0.20.20.9-1.50.71.2-0.51.0
Bone volume0.20.31.20.41.1-0.1-0.1-0.40.2-0.80.0
Breakpoint value in progressive ratio session0.20.21.20.10.3-0.00.3-0.2-0.50.4-1.1
Number of licking bursts0.91.44.8-0.8-0.71.1-1.20.21.0-1.32.2
Context. condit. distance diff. score1.61.95.41.81.5-0.3-0.30.9-0.22.3-1.9
Locomotion velocity, session 10.50.51.6-1.3-1.20.20.4-0.20.1-0.90.4
Locomotion distance, session 10.20.20.50.50.5-0.40.4-0.1-0.70.1-0.6
Locomotion velocity, session 20.20.30.60.60.6-0.50.4-0.1-0.8-0.1-0.6
Locomotion distance, session 20.10.20.50.30.5-0.40.5-0.1-0.7-0.4-0.4
Locomotion velocity, session 30.50.50.80.90.8-0.80.7-0.7-0.9-0.2-0.6
Locomotion distance, session 30.10.10.60.20.30.20.00.1-0.30.2-0.8
Stereotopy head waving bouts, day 30.30.31.1-0.5-0.8-0.10.3-0.30.1-0.71.0
Stereotopy head waving duration, day 30.20.31.0-0.2-0.4-0.50.3-0.3-0.1-0.71.0
Locomotion velocity, session 71.61.82.81.11.3-1.51.4-1.7-1.4-1.2-0.7
Locomotion distance, session 70.70.91.61.31.2-0.80.8-0.7-0.9-0.0-1.2
Stereotopy head waving bouts, day 70.40.40.8-0.7-0.60.8-0.70.60.90.30.1
Stereotopy head waving duration, day 70.20.20.7-0.8-0.70.30.2-0.00.30.1-0.4
Locomotion velocity, session 81.01.24.80.70.7-0.40.20.7-0.21.8-2.2
Locomotion distance, session 81.52.15.41.91.9-0.6-0.00.6-0.61.9-2.3
Degree of sensitization distance0.80.81.51.21.1-1.20.8-0.6-0.70.2-0.8
Degree of sensitization stereotypy0.20.20.3-0.3-0.30.6-0.60.60.50.5-0.2
Conditioned locomotion0.70.82.90.00.10.00.20.8-0.21.6-1.7
Cocaine response after cond. corrected0.40.51.10.90.6-1.10.6-0.6-1.0-0.40.2
Cocaine response after cond. not corrected0.20.20.70.80.8-0.6-0.0-0.3-0.3-0.20.1
Cocaine response before conditioning0.60.72.0-0.50.11.2-1.30.71.40.00.3
Saline control response0.40.60.80.80.8-0.80.9-0.7-0.9-0.0-0.7
Bone: connectivity density0.71.12.0-1.3-0.61.2-1.10.61.2-0.71.4
Bone: cortical apparent density0.60.81.9-0.9-0.5-0.61.3-1.4-0.6-1.0-0.3
Bone: cortical area0.10.20.7-0.40.00.2-0.2-0.20.7-0.80.3
Bone: cortical porosity0.91.01.9-0.7-0.91.2-1.31.01.40.50.8
Bone: cortical porosity2.12.33.7-1.5-1.91.7-1.61.31.90.31.3
Bone: cortical thickness1.01.63.7-1.5-1.31.5-1.31.11.90.40.3
Bone: cortical thickness0.40.41.10.60.60.2-1.00.20.5-0.31.1
Bone: cortical tissue density0.60.81.9-0.9-0.6-0.61.4-1.4-0.6-0.9-0.3
Condit. Reinf. active minus inactive responses0.80.93.4-0.9-1.80.5-0.40.10.5-0.41.4
Condit. Reinf. active-inactive response ratio2.93.15.3-1.9-2.31.8-1.91.52.00.61.6
Condit. Reinf. active responses0.20.31.0-0.1-0.5-0.20.3-0.4-0.3-0.71.0
Condit. Reinf. inactive responses1.11.42.21.21.5-1.21.1-1.2-1.4-1.1-0.1
Incentive salience index mean0.20.31.4-0.4-1.20.10.0-0.20.1-0.20.7
Condit. Reinf. lever presses0.00.00.20.0-0.40.1-0.10.10.10.20.1
Condit. Reinf. active minus inactive responses0.00.00.1-0.2-0.1-0.00.3-0.2-0.2-0.10.0
Condit. Reinf. active-inactive response ratio0.10.10.4-0.3-0.4-0.0-0.0-0.20.0-0.50.6
Condit. Reinf. active responses0.10.10.30.30.4-0.30.4-0.4-0.6-0.1-0.0
Condit. Reinf. inactive responses0.60.82.01.21.4-0.50.6-0.4-0.70.4-1.1
Condit. Reinf. lever presses0.40.51.51.11.0-0.70.1-0.2-1.2-0.10.1
Condit. Reinf. lever reinforcers received0.10.20.40.60.4-0.30.3-0.2-0.60.3-0.3
Conditioned reinforcement - actives0.20.31.10.70.6-0.50.5-0.3-0.30.2-1.1
Conditioned reinforcement - inactives1.31.94.21.81.4-1.51.2-1.1-1.00.2-2.0
Conditioned locomotion0.60.81.30.90.7-1.01.0-0.9-0.8-1.10.1
Patch foraging indifference point 0 sec0.10.30.90.50.9-0.50.2-0.1-0.50.4-0.7
Patch foraging indifference point AUC2.33.46.21.61.1-2.52.3-2.1-2.2-1.3-0.9
Delay disc. indifference point, 0s delay0.30.31.0-0.1-0.3-0.20.5-0.7-0.1-1.00.7
Delay disc. indifference point, 16s delay0.40.41.4-1.2-1.20.40.5-0.20.2-0.2-0.4
Delay disc. indifference point, 2s delay3.13.55.22.01.8-2.22.2-2.0-2.3-1.2-0.8
Delay disc. indifference point, 24s delay0.10.10.20.20.1-0.30.3-0.1-0.40.3-0.4
Delay disc. indifference point, 4s delay1.01.02.20.20.1-0.91.4-1.3-1.1-1.50.5
Delay disc. indifference point, 8s delay0.40.51.5-1.2-1.10.7-0.20.30.4-0.00.6
Indifference point function ln k0.91.63.2-0.8-0.41.8-1.61.41.80.90.7
Indifference point function log k0.91.63.2-0.8-0.41.8-1.61.41.80.90.7
Patch foraging total patch changes 0 sec0.20.41.20.61.1-0.60.3-0.2-0.50.4-0.8
Patch foraging total patch changes 12 sec0.70.91.80.20.5-1.21.3-0.9-1.2-0.2-1.1
Patch foraging total patch changes 18 sec0.10.20.50.1-0.0-0.70.2-0.7-0.4-0.5-0.2
Patch foraging total patch changes 24 sec1.22.03.51.41.9-1.51.2-0.7-1.80.5-1.7
Patch foraging total patch changes 6 sec1.21.82.71.31.4-1.61.5-1.4-1.5-0.6-1.0
Patch foraging time to switch 0 sec1.53.06.1-2.5-2.32.0-1.61.61.51.00.5
Patch foraging water rate 0 sec1.12.44.01.61.7-1.51.0-1.9-1.1-2.01.2
Patch foraging water rate 12 sec0.20.41.61.20.9-0.3-0.1-0.2-0.2-0.30.6
Patch foraging water rate 18 sec0.81.24.81.72.2-0.40.1-0.8-0.5-0.90.1
Patch foraging water rate 24 sec0.91.25.71.72.4-0.0-0.6-0.6-0.2-0.50.4
Patch foraging water rate 6 sec0.71.01.91.21.4-0.90.8-1.1-1.0-1.00.2
Seeking ratio, delayed vs. immediate footshock0.20.20.60.60.5-0.80.4-0.6-0.2-0.1-0.3
Distance traveled before self-admin0.10.10.30.20.10.1-0.10.4-0.20.5-0.2
Distance traveled after self-admin2.83.49.43.12.9-1.80.9-1.1-2.1-0.1-0.3
Extensor digitorum longus weight10.340.658.5-7.3-6.97.6-6.46.97.54.31.4
Bone: elastic displacement1.31.53.1-0.4-0.11.5-1.81.51.51.3-0.0
Bone: elastic work2.12.76.4-0.8-0.22.0-2.52.12.21.10.3
Bone: endosteal estimation1.43.06.02.52.0-2.31.3-1.5-1.9-1.1-0.1
Bone: endosteal perimeter0.20.41.30.60.5-0.4-0.30.0-0.3-1.01.2
Epididymis fat weight0.51.64.2-0.6-0.3-1.12.1-1.7-0.9-1.7-0.4
Delta time in closed arm before/after self-admin0.30.30.9-0.7-0.51.0-0.50.40.40.1-0.1
Delta time in open arm before/after self-admin0.70.71.80.30.4-1.01.3-0.8-1.3-0.3-0.6
Diff in mean of infusions in LGA sessions0.50.62.3-0.10.20.4-0.51.00.11.5-1.0
Delay discount exponential model param0.30.31.0-0.10.10.5-1.00.70.80.60.1
Extinction: sum of active levers before priming0.20.20.70.20.30.6-0.80.50.40.40.2
Active lever presses in extinction session 61.11.02.70.60.9-1.00.6-1.3-1.0-1.60.8
Bone: final force0.40.62.3-0.1-0.1-0.2-0.3-0.50.2-1.51.4
Bone: final moment0.50.83.1-0.1-0.1-0.2-0.4-0.60.2-1.71.8
Food consumed during 24 hour testing period0.71.03.01.71.7-0.80.2-0.0-0.70.5-0.8
Glucose0.91.43.21.70.8-1.81.2-0.9-1.6-0.1-0.1
Heart weight0.50.81.8-1.3-0.81.1-0.80.71.10.5-0.2
Delay discount hyperbolic model param0.50.51.2-0.3-0.20.7-1.10.81.00.70.1
Intermittent access intake day 1-15 change0.00.10.30.1-0.00.3-0.30.40.50.4-0.2
Intermittent access intake escalation0.10.20.5-0.2-0.30.4-0.40.50.70.3-0.1
Intermittent access intake escalation 21.61.82.71.61.3-1.61.5-1.5-1.4-1.0-0.4
Intermitt. access day 1 inactive lever presses1.14.212.12.42.3-1.61.6-0.9-1.61.5-3.5
Intermitt. access day 15 inactive lever presses1.32.75.72.42.2-1.71.2-1.8-1.1-0.3-1.7
Intermitt. access escalation Index1.11.62.7-1.6-1.31.4-1.41.11.30.71.0
Intermittent access day 1 total infusions0.10.10.30.60.40.2-0.30.00.30.2-0.5
Intermittent access day 15 total infusions0.20.31.01.00.70.0-0.30.20.30.4-0.6
Intermittent access terminal intake (last 3 days)0.91.23.61.91.6-0.90.6-0.7-0.7-0.2-1.1
Intermittent access total infusions0.10.10.50.70.50.0-0.2-0.00.2-0.0-0.5
Intermittent access day 1 locomotion0.30.41.00.90.6-0.40.5-0.5-0.00.2-1.0
Intermittent access day 15 total locomotion0.40.61.21.10.8-1.00.9-0.8-0.6-0.6-0.3
Intermittent access total locomotion0.20.31.10.1-0.1-0.20.4-0.70.1-1.10.4
Intermittent access standard deviation0.51.12.71.71.4-0.80.5-0.3-0.60.6-1.6
Left kidney weight0.10.31.4-0.2-0.10.1-0.3-0.30.1-1.20.7
Right kidney weight0.31.57.1-0.5-0.5-0.40.4-1.1-0.5-2.71.6
Cocaine induced anxiety0.40.50.9-0.8-1.00.8-0.80.30.8-0.10.8
Post-drug Anxiety0.10.10.7-0.10.10.10.00.1-0.10.6-0.8
Baseline Anxiety1.31.53.11.51.7-0.3-0.10.7-0.61.6-1.8
Tail length0.62.44.21.81.2-1.41.1-1.3-1.8-2.01.3
Length with tail0.83.68.41.91.5-1.50.8-1.7-2.2-2.92.0
Length without tail0.31.01.91.11.2-0.90.3-0.8-1.4-1.20.6
Times rat made contact with spout0.20.20.5-0.10.6-0.20.2-0.70.5-0.7-0.0
Lifetime Intake0.10.10.30.20.00.5-0.50.30.50.1-0.3
Liver weight, left1.01.63.30.60.4-1.41.7-1.8-1.1-1.80.5
Liver weight, right0.50.91.80.90.8-1.20.9-1.3-0.9-1.0-0.4
Locomotor activity0.61.03.61.21.9-0.90.0-0.4-0.9-0.7-0.6
Locomotor testing distance0.40.72.30.81.50.1-1.10.90.10.5-0.5
Locomotor testing rearing0.20.40.80.70.80.1-0.90.8-0.20.60.5
Locomotion in novel chamber0.00.00.1-0.40.10.2-0.2-0.10.1-0.10.2
Locomotion in novel chamber post-restriction0.91.43.00.40.6-1.01.4-1.4-1.5-1.71.0
Fecal boli incidents, locomotor time 10.91.32.2-1.1-1.11.3-1.51.31.0-0.21.4
Change in fecal boli incidents, locomotor task0.10.10.3-0.0-0.10.6-0.30.10.60.30.5
Time >=10cm from walls, locomotor time 10.91.01.9-0.9-0.90.9-1.11.10.90.21.4
Bouts of movement, locomotor time 10.30.41.1-0.9-1.10.5-0.20.40.5-0.40.3
Total resting periods, locomotor time 10.30.30.8-0.7-0.90.3-0.10.20.3-0.70.5
Rest time, locomotor task time 10.50.61.41.10.9-0.3-0.50.0-0.2-0.81.2
Distance moved, locomotor task time 10.10.20.5-0.7-0.60.4-0.20.30.40.5-0.4
Vertical activity count, locomotor time 10.30.71.8-0.5-0.3-0.51.3-1.3-0.6-0.7-0.6
Time >=10cm from walls, locomotor time 20.60.91.8-0.3-0.31.0-1.31.01.00.41.3
Bouts of movement, locomotor time 20.30.50.90.90.8-0.70.8-0.9-0.7-0.4-0.4
Total resting periods, locomotor time 20.30.50.90.70.7-0.70.8-1.0-0.7-0.5-0.2
Rest time, locomotor task time 20.50.62.01.41.4-0.4-0.40.2-0.30.40.2
Distance moved, locomotor task time 22.02.45.1-2.3-2.21.8-1.31.11.60.10.6
Vertical activity count, locomotor time 20.60.81.8-1.3-1.10.40.4-0.70.1-1.31.0
Light reinforcement 10.20.61.00.70.9-0.80.8-0.7-1.0-0.6-0.3
Light reinforcement 20.10.10.2-0.3-0.10.50.10.30.3-0.40.2
Bone: marrow area1.32.86.02.42.0-2.21.3-1.4-1.8-1.0-0.1
Bone: maximum diameter0.30.51.7-0.9-0.30.2-0.0-0.40.5-1.30.9
Bone: maximum force0.30.62.20.20.0-0.0-0.6-0.30.4-1.41.5
Bone: maximum moment0.50.93.20.30.0-0.1-0.6-0.50.4-1.71.8
Mean time between licks in bursts1.22.96.4-2.3-2.51.8-1.21.51.50.01.6
Mean num. licks in bursts1.42.15.01.11.4-1.71.8-1.1-1.10.6-2.2
Cd content in liver3.03.34.7-2.1-1.82.0-1.82.21.81.90.2
Co content in liver0.30.31.4-0.2-0.50.1-0.40.10.4-0.71.2
Cu content in liver0.30.41.40.4-0.3-0.40.3-0.4-0.5-0.91.2
Fe content in liver1.11.44.5-0.7-1.1-0.10.1-0.9-0.2-2.02.1
K content in liver1.71.64.20.90.8-1.52.0-1.3-1.4-0.1-1.2
Mg content in liver0.90.92.80.50.3-1.01.7-1.2-1.1-0.5-0.6
Mn content in liver0.20.20.90.10.40.10.20.30.20.7-1.0
Na content in liver1.41.52.80.50.3-1.31.1-1.6-1.0-1.71.4
Rb content in liver0.50.61.9-0.8-1.40.7-0.30.20.7-0.31.0
Se content in liver0.40.51.50.30.4-0.81.2-0.7-0.8-0.3-0.5
Sr content in liver0.90.82.0-0.1-0.21.0-1.41.21.10.90.1
Zn content in liver0.30.40.9-0.4-0.90.30.10.9-0.01.0-0.1
Bone: minimum diameter3.56.49.32.92.5-3.02.2-2.8-2.6-2.80.3
Time in familiar zone, hab. session 10.70.62.00.40.80.2-0.20.60.11.3-1.4
Time in novel zone, hab. session 11.11.12.8-0.8-1.3-0.40.6-0.9-0.3-1.71.4
Total zone transitions, hab. session 10.20.20.8-0.00.5-0.10.3-0.1-0.9-0.90.2
Total locomotion distance, hab. session 11.11.53.71.91.9-1.20.7-0.6-1.5-0.4-0.2
Locomotion velocity, hab. session 10.91.23.61.81.9-1.00.3-0.4-1.2-0.2-0.2
Time in familiar zone, hab. session 20.50.51.2-0.6-0.60.9-0.80.71.10.60.0
Time in novel zone, hab. session 20.90.91.70.0-0.1-1.01.3-1.2-1.2-1.10.2
Total zone transitions, hab. session 20.40.51.2-0.40.50.7-1.10.70.6-0.40.8
Total locomotion distance, hab. session 20.30.41.60.71.3-0.0-0.60.00.2-0.50.5
Locomotion velocity, hab. session 20.30.41.70.81.3-0.1-0.60.10.0-0.40.5
Novel to familiar place preference ratio0.70.71.9-0.3-0.6-0.50.9-1.1-0.8-1.40.8
Novelty place preference1.01.12.9-0.6-1.0-0.50.9-1.1-0.8-1.71.2
Time in novel zone, NPP test1.21.33.5-0.4-0.8-0.71.2-1.4-1.0-1.91.0
Total zone transitions, NPP test0.10.10.3-0.6-0.10.2-0.20.20.1-0.40.2
Total locomotion distance, NPP test0.20.20.60.40.30.2-0.80.40.3-0.30.8
Locomotion velocity, NPP test0.30.41.10.1-0.00.5-1.10.80.6-0.00.9
Intraocular pressure1.11.55.2-1.4-1.40.5-0.50.1-0.0-1.62.3
Delta distance traveled before/after self-admin2.22.35.72.42.4-1.60.7-1.3-1.5-0.70.1
Delta ambulatory time before/after self-admin0.81.03.11.81.6-0.90.2-0.8-0.8-0.30.2
Parametrial fat weight1.53.66.41.11.7-2.02.1-2.5-1.9-2.40.4
Pavlov. Cond. lever latency1.72.24.8-1.5-0.81.8-2.21.61.70.31.0
Pavlov. Cond. magazine entry latency0.20.20.90.3-0.4-0.0-0.20.60.21.0-0.1
Pavlov. Cond. change in total contacts0.30.31.10.4-0.1-0.61.0-0.5-0.50.3-0.6
Pavlov. Cond. index score0.50.71.70.90.1-1.01.3-0.7-0.80.3-0.9
Pavlov. Cond. latency score0.70.81.91.00.2-1.11.4-0.7-0.90.3-1.0
Pavlov. Cond. lever contacts1.21.43.01.30.7-1.41.7-1.3-1.4-0.4-0.8
Pavlov. Cond. magazine entry number0.10.10.2-0.30.20.4-0.30.00.0-0.40.4
Pavlov. Cond. intertrial magazine entries1.01.22.40.20.4-0.91.3-1.5-1.4-1.60.6
Pavlov. Cond. lever-magazine prob. diff.0.60.81.70.90.3-1.11.3-0.7-0.90.3-1.0
Pavlov. Cond. response bias0.50.61.40.90.2-1.01.2-0.8-0.9-0.0-0.5
Pavlov. Cond. lever latency0.30.51.4-0.1-0.2-0.81.2-0.9-0.3-0.5-0.5
Pavlov. Cond. magazine entry latency1.41.63.2-0.7-1.11.4-1.81.70.90.41.5
Pavlov. Cond. change in total contacts0.40.61.5-0.1-0.21.0-1.21.10.70.70.6
Pavlov. Cond. index score0.71.02.7-0.1-0.31.1-1.61.40.70.51.1
Pavlov. Cond. latency score1.11.53.8-0.4-0.51.4-1.91.81.00.90.9
Pavlov. Cond. lever contacts0.20.20.70.40.40.5-0.90.5-0.00.10.6
Pavlov. Cond. magazine entry number1.92.34.90.91.0-1.82.2-2.1-1.3-0.4-1.7
Pavlov. Cond. intertrial magazine entries1.11.73.30.80.9-1.51.8-1.8-1.3-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.82.2-0.1-0.30.9-1.51.30.50.51.0
Pavlov. Cond. response bias0.40.61.6-0.0-0.10.9-1.31.00.30.11.0
Time in closed arm before self-admin0.30.40.80.70.4-0.90.7-0.7-0.6-0.2-0.4
Time in closed arm after self-admin0.20.20.40.50.6-0.20.20.2-0.50.5-0.7
Time in open arm before self-admin0.91.02.90.10.50.9-1.71.01.30.80.5
Time in open arm after self-admin0.40.51.00.20.4-0.90.9-1.0-0.8-0.70.0
Bone: periosteal estimation0.40.81.51.11.0-1.20.6-0.9-0.6-1.20.2
Bone: periosteal perimeter0.20.30.8-0.2-0.10.3-0.70.30.5-0.90.9
Bone: post-yield work0.60.92.10.7-0.0-1.00.7-1.1-0.5-1.51.3
Progressive ratio test 1 active lever presses0.30.40.90.90.6-0.50.1-0.6-0.3-0.90.6
Progressive ratio test 1 breakpoint0.30.41.01.00.7-0.50.1-0.5-0.3-0.80.5
Progressive ratio test 1 inactive lever presses1.82.68.12.21.8-1.11.0-0.8-0.91.1-2.9
Progressive ratio test 2 active lever presses0.30.30.50.70.6-0.60.7-0.5-0.5-0.3-0.7
Progressive ratio test 2 breakpoint0.30.30.60.70.6-0.60.7-0.5-0.5-0.3-0.8
Progressive ratio test 2 inactive lever presses1.22.03.31.81.7-1.61.2-1.3-1.2-0.2-1.6
Incentive Sensitization - Responses0.20.31.90.00.1-0.20.7-0.0-0.30.5-1.4
Incentive Sensitization - Breakpoint0.30.31.90.10.2-0.20.60.0-0.30.5-1.4
Sum of active levers in priming session hrs 5-60.60.62.10.60.70.00.10.3-0.31.2-1.5
Progressive ratio0.20.30.7-0.1-0.10.7-0.70.80.30.80.1
Food seeking constrained by brief footshock0.50.61.0-0.5-0.81.0-1.00.61.00.10.7
Seeking ratio, punishment vs. effort0.60.92.10.60.5-1.21.2-1.4-0.7-1.0-0.5
Retroperitoneal fat weight0.62.56.20.30.8-1.61.8-2.1-1.4-2.50.8
Reaction time number correct0.40.73.3-0.2-0.30.7-0.90.40.5-0.81.8
Reaction time mean minus median0.30.82.8-1.0-1.00.3-0.5-0.30.2-1.11.7
Reaction time mean minus median AUC0.30.71.6-1.2-1.30.10.2-0.7-0.0-1.01.0
Reaction time num false alarms0.50.73.0-0.5-0.7-0.41.2-0.3-0.00.3-1.7
Reaction time num false alarms AUC0.40.72.2-0.9-1.2-0.11.00.00.20.3-1.5
Reaction time trials correct on left0.40.73.3-0.2-0.30.7-0.90.40.5-0.81.8
Reaction time trials on left0.40.83.6-0.2-0.40.7-1.00.50.5-0.81.9
Reaction time mean0.10.20.4-0.6-0.60.20.2-0.40.4-0.20.6
Reaction time mean AUC0.10.20.4-0.5-0.5-0.00.5-0.60.2-0.30.5
Median of all reaction times0.10.10.2-0.4-0.40.10.4-0.30.30.20.1
Reaction time omissions1.11.62.7-1.3-1.71.5-1.31.21.00.11.4
Reaction time false alarm rate0.91.25.7-0.6-0.8-0.51.5-0.3-0.20.7-2.4
Reaction time premature initiation rate0.81.22.41.01.0-1.11.3-1.5-0.9-0.4-0.9
Reaction time premature initiations0.50.92.30.90.9-0.91.0-1.5-0.7-1.00.1
Std. dev. reaction times0.20.41.2-0.8-0.90.2-0.2-0.40.3-0.61.1
Reaction time trials completed0.40.83.6-0.2-0.40.7-1.00.50.5-0.81.9
Reaction time trials AUC0.51.04.6-0.4-0.50.8-1.00.40.5-1.02.1
Run reversals in cocaine runway, females1.41.43.21.81.7-1.00.8-1.2-1.0-1.1-0.1
Run reversals in cocaine runway, males0.60.71.2-0.5-0.51.1-0.70.81.01.1-0.7
Latency to leave start box in cocaine runway1.11.32.31.10.8-1.51.0-1.3-0.9-1.50.7
Latency to leave start box in cocaine runway, F2.73.14.81.91.5-2.22.1-2.0-1.9-1.5-0.2
Latency to leave start box in cocaine runway, M0.70.72.6-0.4-0.40.5-1.10.30.8-0.71.6
Std. dev. time between licks in bursts0.40.61.3-0.7-0.80.9-0.81.10.40.70.4
Total sessions with >9 infusions0.80.91.8-0.9-1.11.3-1.00.71.3-0.00.7
Short access day 1 total inactive lever presses1.01.32.91.51.6-0.60.10.2-0.51.2-1.7
Short access day 10 total inactive lever presses0.51.32.71.41.6-0.90.30.1-0.81.3-1.6
Short access day 1 total infusions0.10.10.20.40.2-0.10.3-0.3-0.3-0.3-0.4
Short access day 10 total infusions0.10.10.40.20.00.4-0.50.60.30.3-0.1
Short access total infusions0.40.51.1-0.4-0.51.1-0.80.70.80.4-0.1
Short access day 1 locomotion0.20.30.90.50.4-0.0-0.3-0.20.1-0.90.9
Short access day 10 total locomotion0.10.31.20.30.1-0.10.30.00.30.7-1.1
Short access total locomotion0.10.10.30.0-0.20.2-0.20.10.60.10.0
One hour access (0.3 mA shock)0.91.03.11.01.1-0.70.5-1.1-0.7-1.70.9
Compulsive drug intake0.30.30.9-0.4-0.00.9-0.90.60.30.40.4
One hour access (shock baseline)0.61.01.80.80.6-1.21.2-1.2-0.8-1.3-0.0
Social response proportion1.72.03.91.10.9-2.01.8-1.7-1.5-1.1-0.3
Social responses0.70.91.50.80.3-1.21.2-1.0-1.1-0.5-0.9
Social time0.20.30.50.3-0.1-0.70.7-0.6-0.7-0.70.4
Soleus weight1.95.713.6-0.9-0.42.3-2.03.12.23.7-2.8
Bone: stiffness1.32.25.80.70.4-1.51.3-1.9-1.3-2.41.1
Tibialis anterior weight3.712.620.0-4.3-4.54.2-2.83.74.02.5-0.1
Time to tail flick, vehicle, before self-admin1.31.43.01.21.1-1.00.7-1.5-0.9-1.70.7
Time to tail flick, vehicle, after self-admin0.81.13.71.91.7-0.80.2-0.1-0.70.4-0.8
Time to tail flick, test, before self-admin0.40.41.00.3-0.10.3-0.30.41.01.0-0.8
Time to tail flick, test, after self-admin1.51.52.71.61.2-1.31.3-1.6-0.8-1.20.0
Delta time to tail flick, vehicle, before/after SA0.30.31.50.50.2-0.20.20.2-0.10.6-1.2
Delta time to tail flick, test, before/after SA1.41.52.60.70.6-1.31.5-1.5-1.4-1.60.3
Tibia length0.20.71.20.30.6-0.81.1-1.1-1.0-1.0-0.1
Ambulatory time before self-admin0.10.20.60.40.3-0.10.20.2-0.30.6-0.7
Ambulatory time after self-admin2.22.67.32.72.5-1.60.8-1.0-1.7-0.3-0.1
Bone: tissue strength0.40.40.80.50.8-0.50.3-0.6-0.9-0.90.4
Total heroin consumption0.30.41.31.11.1-0.4-0.2-0.5-0.4-0.30.3
Bone: trabecular number0.20.30.8-0.70.20.4-0.1-0.40.2-0.90.6
Bone: trabecular spacing0.40.51.6-0.1-0.9-0.71.3-0.4-0.30.5-1.0
Bone: trabecular thickness0.20.31.40.61.20.1-0.2-0.2-0.1-0.50.1
Bone: trabecular tissue density0.40.61.8-1.1-1.30.4-0.1-0.00.4-0.51.1
Water consumed over 24 hours0.71.03.01.21.7-0.90.4-1.1-0.3-1.1-0.0
Number of responses in last shaping day0.10.10.1-0.3-0.30.00.30.20.20.2-0.4