Hub : Genes

Grsf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Grsf1 0.11 0.05 1.4e-14 0.12 0.12 0.12 0.12 5.0e-13 5.9e-13 2.1e-13 2.8e-13
2 Liver gene expression Grsf1 0.1 0.06 4.1e-08 0.05 0.06 0.07 0.06 2.2e-06 4.8e-07 2.0e-08 2.4e-07
3 pVTA gene expression Grsf1 0.1 0.06 5.0e-06 0.08 0.04 0.06 0.07 7.3e-07 4.0e-04 1.4e-05 2.7e-06
4 pVTA mRNA stability Grsf1 0.03 0.02 5.4e-03 0.01 0.02 0.02 0.01 3.6e-02 1.6e-02 1.1e-02 4.9e-02
5 Brain gene expression Grsf1 0.16 0.07 1.2e-08 0.06 0.1 0.1 0.09 1.2e-06 3.9e-09 2.6e-09 2.0e-08
6 BLA gene expression Grsf1 0.05 0.04 8.6e-03 0.04 0.04 0.03 0.03 5.4e-03 5.9e-03 8.8e-03 1.3e-02
7 NAcc gene expression Grsf1 0.09 0.05 1.5e-08 0.02 0.05 0.05 0.05 6.8e-04 1.1e-08 1.9e-08 2.0e-08
8 Brain mRNA stability Grsf1 0.08 0.06 8.3e-03 0.01 0.02 0.02 0.03 1.4e-02 2.6e-03 7.6e-03 8.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.30.50.80.7-0.0-0.80.8-0.2-0.9-0.60.9
Area under the delay curve0.20.30.80.10.20.4-0.90.70.7-0.6-0.0
BMI with tail1.13.911.63.42.3-2.10.9-1.5-2.21.3-0.6
BMI without tail0.52.98.22.92.5-1.80.7-1.2-1.90.50.3
Body weight0.20.92.71.30.8-0.4-0.20.50.1-1.61.1
Weight adjusted by age0.20.71.60.60.4-0.71.3-1.0-0.60.31.1
Bone surface0.40.82.10.2-0.2-0.91.5-0.7-1.2-0.51.0
Bone volume0.10.31.2-0.4-1.10.10.10.4-0.2-0.80.0
Breakpoint value in progressive ratio session0.10.21.2-0.1-0.30.0-0.30.20.50.4-1.1
Number of licking bursts0.51.44.80.80.7-1.11.2-0.2-1.0-1.32.2
Context. condit. distance diff. score1.61.95.4-1.8-1.50.30.3-0.90.22.3-1.9
Locomotion velocity, session 10.50.51.61.31.2-0.2-0.40.2-0.1-0.90.4
Locomotion distance, session 10.20.20.5-0.5-0.50.4-0.40.10.70.1-0.6
Locomotion velocity, session 20.20.30.6-0.6-0.50.5-0.40.10.8-0.1-0.6
Locomotion distance, session 20.10.20.5-0.3-0.50.4-0.50.10.7-0.4-0.4
Locomotion velocity, session 30.50.50.8-0.9-0.80.8-0.70.70.9-0.2-0.6
Locomotion distance, session 30.10.10.6-0.2-0.3-0.2-0.0-0.10.30.2-0.8
Stereotopy head waving bouts, day 30.30.31.10.50.80.1-0.30.3-0.1-0.71.0
Stereotopy head waving duration, day 30.20.31.00.20.40.5-0.30.30.1-0.71.0
Locomotion velocity, session 71.61.82.8-1.1-1.31.5-1.41.71.4-1.2-0.7
Locomotion distance, session 70.70.91.6-1.3-1.20.8-0.80.70.9-0.0-1.2
Stereotopy head waving bouts, day 70.40.40.80.70.6-0.80.7-0.6-0.90.30.1
Stereotopy head waving duration, day 70.20.20.70.80.7-0.3-0.20.0-0.30.1-0.4
Locomotion velocity, session 81.01.24.8-0.7-0.70.4-0.2-0.70.21.8-2.2
Locomotion distance, session 81.52.15.4-1.9-1.90.60.0-0.60.61.9-2.3
Degree of sensitization distance0.70.81.5-1.2-1.11.2-0.80.60.70.2-0.8
Degree of sensitization stereotypy0.20.20.30.30.3-0.60.6-0.6-0.50.5-0.2
Conditioned locomotion0.70.82.9-0.0-0.1-0.0-0.2-0.80.21.6-1.7
Cocaine response after cond. corrected0.40.51.1-0.9-0.61.1-0.60.61.0-0.40.2
Cocaine response after cond. not corrected0.20.20.7-0.8-0.80.60.00.30.3-0.20.1
Cocaine response before conditioning0.60.72.00.5-0.1-1.21.3-0.7-1.40.00.3
Saline control response0.40.60.8-0.8-0.80.8-0.90.70.9-0.0-0.7
Bone: connectivity density0.71.12.01.30.6-1.21.1-0.6-1.2-0.71.4
Bone: cortical apparent density0.50.81.90.90.50.6-1.31.40.6-1.0-0.3
Bone: cortical area0.10.20.70.4-0.0-0.20.20.2-0.7-0.80.3
Bone: cortical porosity0.91.01.90.70.9-1.21.3-1.0-1.40.50.8
Bone: cortical porosity2.12.33.71.51.9-1.71.6-1.3-1.90.31.3
Bone: cortical thickness1.01.63.71.51.3-1.51.3-1.1-1.90.40.3
Bone: cortical thickness0.40.41.1-0.6-0.6-0.21.0-0.2-0.5-0.31.1
Bone: cortical tissue density0.50.81.90.90.60.6-1.41.40.6-0.9-0.3
Condit. Reinf. active minus inactive responses0.80.93.30.91.8-0.50.4-0.1-0.5-0.41.4
Condit. Reinf. active-inactive response ratio2.93.15.31.92.3-1.81.9-1.5-2.00.61.6
Condit. Reinf. active responses0.20.31.00.10.50.2-0.30.40.3-0.71.0
Condit. Reinf. inactive responses1.11.42.2-1.2-1.51.2-1.11.21.4-1.1-0.1
Incentive salience index mean0.20.31.40.41.2-0.1-0.00.2-0.1-0.20.7
Condit. Reinf. lever presses0.00.00.2-0.00.4-0.10.1-0.1-0.10.20.1
Condit. Reinf. active minus inactive responses0.00.00.10.20.10.0-0.30.20.2-0.10.0
Condit. Reinf. active-inactive response ratio0.10.10.40.30.40.00.00.2-0.0-0.50.6
Condit. Reinf. active responses0.10.10.3-0.3-0.40.3-0.40.40.6-0.1-0.0
Condit. Reinf. inactive responses0.50.82.0-1.2-1.40.5-0.60.40.70.4-1.1
Condit. Reinf. lever presses0.40.51.5-1.1-1.00.7-0.10.21.2-0.10.1
Condit. Reinf. lever reinforcers received0.10.20.4-0.6-0.40.3-0.30.20.60.3-0.3
Conditioned reinforcement - actives0.10.31.1-0.7-0.60.5-0.50.30.30.2-1.1
Conditioned reinforcement - inactives0.71.94.2-1.8-1.41.5-1.21.11.00.2-2.0
Conditioned locomotion0.50.81.3-0.9-0.71.0-1.00.90.8-1.10.1
Patch foraging indifference point 0 sec0.10.30.9-0.5-0.90.5-0.20.10.50.4-0.7
Patch foraging indifference point AUC1.43.46.2-1.6-1.12.5-2.32.12.2-1.3-0.9
Delay disc. indifference point, 0s delay0.30.31.00.10.30.2-0.50.70.1-1.00.7
Delay disc. indifference point, 16s delay0.30.41.41.21.2-0.4-0.40.2-0.2-0.2-0.4
Delay disc. indifference point, 2s delay3.13.55.2-2.0-1.82.2-2.22.02.3-1.2-0.8
Delay disc. indifference point, 24s delay0.00.10.2-0.2-0.10.3-0.30.10.40.3-0.4
Delay disc. indifference point, 4s delay1.01.02.2-0.2-0.10.9-1.41.31.1-1.50.5
Delay disc. indifference point, 8s delay0.30.51.51.21.1-0.70.2-0.3-0.4-0.00.6
Indifference point function ln k0.51.63.20.80.4-1.81.6-1.4-1.80.90.7
Indifference point function log k0.51.63.20.80.4-1.81.6-1.4-1.80.90.7
Patch foraging total patch changes 0 sec0.10.41.2-0.6-1.10.6-0.30.20.50.4-0.8
Patch foraging total patch changes 12 sec0.70.91.8-0.2-0.51.2-1.30.91.2-0.2-1.1
Patch foraging total patch changes 18 sec0.10.20.5-0.10.00.7-0.20.70.4-0.5-0.2
Patch foraging total patch changes 24 sec0.62.03.5-1.4-1.91.5-1.20.71.80.5-1.7
Patch foraging total patch changes 6 sec1.11.82.7-1.3-1.41.6-1.51.41.5-0.6-1.0
Patch foraging time to switch 0 sec0.83.06.12.52.3-2.01.6-1.6-1.51.00.5
Patch foraging water rate 0 sec0.62.44.0-1.6-1.81.5-1.01.91.1-2.01.2
Patch foraging water rate 12 sec0.10.41.6-1.2-0.90.30.10.20.2-0.30.6
Patch foraging water rate 18 sec0.51.24.8-1.7-2.20.4-0.10.80.5-0.90.1
Patch foraging water rate 24 sec0.91.25.7-1.7-2.40.00.50.60.2-0.50.4
Patch foraging water rate 6 sec0.71.01.9-1.2-1.40.9-0.81.11.0-1.00.2
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.6-0.50.8-0.40.60.2-0.1-0.3
Distance traveled before self-admin0.00.10.3-0.2-0.1-0.10.1-0.40.20.5-0.2
Distance traveled after self-admin2.03.49.4-3.1-2.91.8-0.91.12.1-0.1-0.3
Extensor digitorum longus weight10.240.658.57.36.9-7.66.4-6.9-7.54.31.4
Bone: elastic displacement1.11.53.10.40.1-1.51.8-1.5-1.51.3-0.0
Bone: elastic work2.12.76.40.80.2-2.02.5-2.1-2.21.10.3
Bone: endosteal estimation1.23.06.0-2.5-2.02.3-1.31.51.9-1.1-0.1
Bone: endosteal perimeter0.20.41.3-0.6-0.50.40.3-0.00.3-1.01.2
Epididymis fat weight0.31.64.20.60.31.1-2.01.70.9-1.7-0.4
Delta time in closed arm before/after self-admin0.30.30.90.70.5-1.00.5-0.4-0.40.1-0.1
Delta time in open arm before/after self-admin0.60.71.8-0.3-0.41.0-1.30.81.3-0.3-0.6
Diff in mean of infusions in LGA sessions0.30.62.30.1-0.2-0.40.5-1.0-0.11.5-1.0
Delay discount exponential model param0.30.31.00.1-0.1-0.51.0-0.7-0.80.60.1
Extinction: sum of active levers before priming0.10.20.7-0.2-0.3-0.60.8-0.5-0.40.40.2
Active lever presses in extinction session 61.01.02.7-0.6-0.91.0-0.61.31.0-1.60.8
Bone: final force0.40.62.30.10.10.20.30.5-0.2-1.51.4
Bone: final moment0.50.83.10.10.10.20.40.6-0.2-1.71.8
Food consumed during 24 hour testing period0.51.03.0-1.7-1.70.8-0.20.00.70.5-0.8
Glucose0.91.43.2-1.7-0.81.8-1.20.91.6-0.1-0.1
Heart weight0.50.81.81.30.8-1.10.8-0.7-1.10.5-0.2
Delay discount hyperbolic model param0.40.51.20.30.2-0.71.1-0.8-1.00.70.1
Intermittent access intake day 1-15 change0.00.10.3-0.10.0-0.30.3-0.4-0.50.4-0.2
Intermittent access intake escalation0.00.20.50.20.3-0.40.4-0.5-0.70.3-0.1
Intermittent access intake escalation 21.11.82.7-1.6-1.31.6-1.51.51.4-1.0-0.4
Intermitt. access day 1 inactive lever presses0.34.212.1-2.4-2.31.6-1.60.91.61.5-3.5
Intermitt. access day 15 inactive lever presses0.52.75.7-2.4-2.21.7-1.21.81.1-0.3-1.7
Intermitt. access escalation Index0.51.62.71.61.3-1.41.4-1.1-1.30.71.0
Intermittent access day 1 total infusions0.00.10.3-0.6-0.4-0.20.3-0.0-0.30.2-0.5
Intermittent access day 15 total infusions0.10.31.0-1.0-0.7-0.00.3-0.2-0.30.4-0.6
Intermittent access terminal intake (last 3 days)0.71.23.6-1.9-1.60.9-0.60.70.7-0.2-1.1
Intermittent access total infusions0.10.10.5-0.7-0.5-0.00.20.0-0.2-0.0-0.5
Intermittent access day 1 locomotion0.20.41.0-0.9-0.60.4-0.50.50.00.2-1.0
Intermittent access day 15 total locomotion0.20.61.2-1.1-0.81.0-0.90.80.6-0.6-0.3
Intermittent access total locomotion0.20.31.1-0.10.10.2-0.40.7-0.1-1.10.4
Intermittent access standard deviation0.21.12.7-1.7-1.40.8-0.50.30.60.6-1.6
Left kidney weight0.00.31.40.20.1-0.10.30.3-0.1-1.20.7
Right kidney weight0.21.57.10.50.50.4-0.41.10.5-2.71.6
Cocaine induced anxiety0.20.50.90.81.0-0.80.8-0.3-0.8-0.10.8
Post-drug Anxiety0.10.10.70.1-0.1-0.1-0.0-0.10.10.6-0.8
Baseline Anxiety0.91.53.1-1.5-1.70.30.1-0.70.61.6-1.8
Tail length0.42.44.2-1.8-1.21.4-1.11.31.8-2.01.3
Length with tail0.83.68.4-1.9-1.51.5-0.81.72.2-2.92.0
Length without tail0.21.01.9-1.1-1.20.9-0.30.81.4-1.20.6
Times rat made contact with spout0.20.20.50.1-0.60.2-0.20.7-0.5-0.7-0.0
Lifetime Intake0.10.10.3-0.2-0.0-0.50.5-0.3-0.50.1-0.3
Liver weight, left0.91.63.3-0.6-0.41.4-1.71.81.1-1.80.5
Liver weight, right0.50.91.8-0.9-0.81.2-0.91.30.9-1.0-0.4
Locomotor activity0.61.03.6-1.2-1.90.9-0.00.40.9-0.7-0.6
Locomotor testing distance0.30.72.3-0.8-1.5-0.11.1-0.9-0.10.5-0.5
Locomotor testing rearing0.10.40.8-0.7-0.8-0.10.9-0.80.20.60.5
Locomotion in novel chamber0.00.00.10.4-0.1-0.20.20.1-0.1-0.10.2
Locomotion in novel chamber post-restriction0.51.43.0-0.4-0.61.0-1.41.41.5-1.71.0
Fecal boli incidents, locomotor time 10.51.32.21.11.0-1.31.5-1.3-1.0-0.21.4
Change in fecal boli incidents, locomotor task0.10.10.30.00.1-0.60.3-0.1-0.60.30.5
Time >=10cm from walls, locomotor time 10.81.01.90.90.9-0.91.1-1.1-0.90.21.4
Bouts of movement, locomotor time 10.30.41.10.91.1-0.50.2-0.4-0.5-0.40.3
Total resting periods, locomotor time 10.20.30.80.70.9-0.30.1-0.2-0.3-0.70.5
Rest time, locomotor task time 10.40.61.4-1.1-0.90.30.5-0.00.2-0.81.2
Distance moved, locomotor task time 10.10.20.50.70.6-0.40.2-0.3-0.40.5-0.4
Vertical activity count, locomotor time 10.10.71.80.50.30.5-1.31.30.6-0.7-0.6
Time >=10cm from walls, locomotor time 20.30.91.80.30.3-1.01.3-1.0-1.00.41.3
Bouts of movement, locomotor time 20.20.50.9-0.9-0.80.7-0.80.90.7-0.4-0.4
Total resting periods, locomotor time 20.10.50.9-0.7-0.70.7-0.81.00.7-0.5-0.2
Rest time, locomotor task time 20.30.62.0-1.4-1.40.40.4-0.20.30.40.2
Distance moved, locomotor task time 21.82.45.12.32.2-1.81.3-1.1-1.60.10.6
Vertical activity count, locomotor time 20.40.81.81.31.1-0.4-0.40.7-0.1-1.31.0
Light reinforcement 10.10.61.0-0.7-0.90.8-0.80.71.0-0.6-0.3
Light reinforcement 20.00.10.20.30.1-0.5-0.1-0.3-0.3-0.40.2
Bone: marrow area1.12.86.0-2.4-2.02.2-1.31.41.8-1.0-0.1
Bone: maximum diameter0.20.51.70.90.3-0.20.00.4-0.5-1.30.9
Bone: maximum force0.30.62.2-0.2-0.00.00.60.3-0.4-1.41.5
Bone: maximum moment0.50.93.2-0.3-0.00.10.60.5-0.4-1.71.8
Mean time between licks in bursts0.52.96.32.32.5-1.81.2-1.5-1.50.01.6
Mean num. licks in bursts0.82.15.0-1.1-1.41.7-1.81.11.10.6-2.2
Cd content in liver3.03.34.72.11.8-2.01.8-2.2-1.81.90.2
Co content in liver0.30.31.40.20.5-0.10.4-0.1-0.4-0.71.2
Cu content in liver0.30.41.4-0.40.30.4-0.30.40.5-0.91.2
Fe content in liver1.11.44.50.71.10.1-0.10.90.2-2.02.1
K content in liver1.71.64.2-0.9-0.81.5-2.01.31.4-0.1-1.2
Mg content in liver0.80.92.8-0.5-0.31.0-1.71.21.1-0.5-0.6
Mn content in liver0.20.20.9-0.1-0.4-0.1-0.2-0.3-0.20.7-1.0
Na content in liver1.31.52.8-0.5-0.31.3-1.11.61.0-1.71.4
Rb content in liver0.50.61.90.81.4-0.70.3-0.2-0.7-0.31.0
Se content in liver0.40.51.5-0.3-0.40.8-1.20.70.8-0.3-0.5
Sr content in liver0.90.82.00.10.2-1.01.4-1.2-1.10.90.1
Zn content in liver0.30.40.90.40.9-0.3-0.1-0.90.01.0-0.1
Bone: minimum diameter3.36.49.3-2.9-2.53.0-2.22.82.6-2.80.3
Time in familiar zone, hab. session 10.60.62.0-0.4-0.8-0.20.2-0.6-0.11.3-1.4
Time in novel zone, hab. session 11.01.12.80.81.30.4-0.60.90.3-1.71.4
Total zone transitions, hab. session 10.20.20.80.0-0.50.1-0.30.10.9-0.90.2
Total locomotion distance, hab. session 11.11.53.7-1.9-1.91.2-0.70.61.5-0.4-0.2
Locomotion velocity, hab. session 10.91.23.6-1.8-1.91.0-0.30.41.2-0.2-0.2
Time in familiar zone, hab. session 20.50.51.20.60.6-0.90.8-0.7-1.10.60.0
Time in novel zone, hab. session 20.80.91.7-0.00.11.0-1.31.21.2-1.10.2
Total zone transitions, hab. session 20.40.51.20.4-0.5-0.71.1-0.7-0.6-0.40.8
Total locomotion distance, hab. session 20.30.41.6-0.7-1.30.00.6-0.0-0.2-0.50.5
Locomotion velocity, hab. session 20.30.41.7-0.8-1.30.10.6-0.1-0.0-0.40.5
Novel to familiar place preference ratio0.60.71.90.30.60.5-0.91.10.8-1.40.8
Novelty place preference0.91.12.90.61.00.5-0.91.10.8-1.71.2
Time in novel zone, NPP test1.11.33.50.40.80.7-1.21.41.0-1.91.0
Total zone transitions, NPP test0.10.10.30.60.1-0.20.2-0.2-0.1-0.40.2
Total locomotion distance, NPP test0.20.20.6-0.4-0.3-0.20.8-0.4-0.3-0.30.8
Locomotion velocity, NPP test0.30.41.1-0.10.0-0.51.1-0.8-0.6-0.00.9
Intraocular pressure0.91.55.21.41.4-0.50.5-0.10.0-1.62.3
Delta distance traveled before/after self-admin2.12.35.7-2.4-2.41.6-0.71.31.5-0.70.1
Delta ambulatory time before/after self-admin0.61.03.1-1.8-1.60.9-0.20.80.8-0.30.2
Parametrial fat weight1.53.66.4-1.1-1.72.0-2.12.51.9-2.40.4
Pavlov. Cond. lever latency1.72.24.81.50.8-1.82.2-1.6-1.70.31.0
Pavlov. Cond. magazine entry latency0.20.20.9-0.30.40.00.2-0.6-0.21.0-0.1
Pavlov. Cond. change in total contacts0.30.31.1-0.40.10.6-1.00.50.50.3-0.6
Pavlov. Cond. index score0.50.71.7-0.9-0.11.0-1.30.70.80.3-0.9
Pavlov. Cond. latency score0.70.81.9-1.0-0.21.1-1.40.70.90.3-1.0
Pavlov. Cond. lever contacts1.21.43.0-1.3-0.71.4-1.71.31.4-0.4-0.8
Pavlov. Cond. magazine entry number0.10.10.20.3-0.2-0.40.3-0.0-0.0-0.40.4
Pavlov. Cond. intertrial magazine entries1.01.22.4-0.2-0.40.9-1.31.51.4-1.60.6
Pavlov. Cond. lever-magazine prob. diff.0.60.81.7-0.9-0.31.1-1.30.70.90.3-1.0
Pavlov. Cond. response bias0.50.61.4-0.9-0.21.0-1.20.80.9-0.0-0.5
Pavlov. Cond. lever latency0.30.51.40.10.20.8-1.20.90.3-0.5-0.5
Pavlov. Cond. magazine entry latency1.21.63.20.71.1-1.41.8-1.7-0.90.41.5
Pavlov. Cond. change in total contacts0.30.61.50.10.2-1.01.2-1.1-0.70.70.6
Pavlov. Cond. index score0.61.02.70.10.3-1.11.6-1.4-0.70.51.1
Pavlov. Cond. latency score0.91.53.80.40.5-1.41.9-1.8-1.00.90.9
Pavlov. Cond. lever contacts0.20.20.7-0.4-0.4-0.50.9-0.50.00.10.6
Pavlov. Cond. magazine entry number1.82.34.9-0.9-1.01.8-2.22.11.3-0.4-1.7
Pavlov. Cond. intertrial magazine entries0.81.73.3-0.8-0.91.5-1.81.81.3-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.50.82.20.10.3-0.91.5-1.3-0.50.51.0
Pavlov. Cond. response bias0.40.61.60.00.1-0.91.3-1.0-0.30.11.0
Time in closed arm before self-admin0.20.40.8-0.7-0.40.9-0.70.70.6-0.2-0.4
Time in closed arm after self-admin0.20.20.4-0.5-0.60.2-0.2-0.20.50.5-0.7
Time in open arm before self-admin0.81.02.9-0.1-0.5-0.91.7-1.0-1.30.80.5
Time in open arm after self-admin0.40.51.0-0.2-0.40.9-0.91.00.8-0.70.0
Bone: periosteal estimation0.40.81.5-1.1-1.01.2-0.60.90.6-1.20.2
Bone: periosteal perimeter0.20.30.80.20.1-0.30.7-0.3-0.5-0.90.9
Bone: post-yield work0.50.92.1-0.70.01.0-0.71.10.5-1.51.3
Progressive ratio test 1 active lever presses0.20.40.9-0.9-0.60.5-0.10.60.3-0.90.6
Progressive ratio test 1 breakpoint0.20.41.0-1.0-0.70.5-0.10.50.3-0.80.5
Progressive ratio test 1 inactive lever presses1.02.68.1-2.2-1.81.1-1.00.80.91.1-2.9
Progressive ratio test 2 active lever presses0.20.30.5-0.7-0.60.6-0.70.50.5-0.3-0.7
Progressive ratio test 2 breakpoint0.30.30.6-0.7-0.60.6-0.70.50.5-0.3-0.8
Progressive ratio test 2 inactive lever presses0.62.03.3-1.8-1.71.6-1.21.31.2-0.2-1.6
Incentive Sensitization - Responses0.10.31.9-0.0-0.10.2-0.70.00.30.5-1.4
Incentive Sensitization - Breakpoint0.20.31.9-0.1-0.20.2-0.6-0.00.30.5-1.4
Sum of active levers in priming session hrs 5-60.60.62.1-0.6-0.7-0.0-0.1-0.30.31.2-1.5
Progressive ratio0.10.30.70.10.1-0.70.7-0.8-0.30.80.1
Food seeking constrained by brief footshock0.50.61.00.50.8-1.01.0-0.6-1.00.10.7
Seeking ratio, punishment vs. effort0.40.92.1-0.6-0.51.2-1.21.40.7-1.0-0.5
Retroperitoneal fat weight0.62.56.2-0.3-0.81.6-1.82.11.4-2.50.8
Reaction time number correct0.20.73.30.20.3-0.70.9-0.4-0.5-0.81.8
Reaction time mean minus median0.10.82.81.01.0-0.30.50.3-0.2-1.11.7
Reaction time mean minus median AUC0.10.71.61.21.3-0.1-0.20.70.0-1.01.0
Reaction time num false alarms0.40.73.00.50.70.4-1.20.30.00.3-1.7
Reaction time num false alarms AUC0.30.72.20.91.20.1-1.0-0.0-0.20.3-1.5
Reaction time trials correct on left0.20.73.30.20.3-0.70.9-0.4-0.5-0.81.8
Reaction time trials on left0.20.83.60.20.4-0.71.0-0.5-0.5-0.81.9
Reaction time mean0.10.20.40.60.6-0.2-0.20.4-0.4-0.20.6
Reaction time mean AUC0.10.20.40.50.50.0-0.50.6-0.2-0.30.5
Median of all reaction times0.10.10.20.40.4-0.1-0.40.3-0.30.20.1
Reaction time omissions1.01.62.71.31.7-1.51.3-1.2-1.00.11.4
Reaction time false alarm rate0.91.25.70.60.80.5-1.50.30.20.7-2.4
Reaction time premature initiation rate0.71.22.4-1.0-1.01.1-1.31.50.9-0.4-0.9
Reaction time premature initiations0.30.92.3-0.9-0.90.9-1.01.50.7-1.00.1
Std. dev. reaction times0.10.41.20.80.9-0.20.20.4-0.3-0.61.1
Reaction time trials completed0.20.83.60.20.4-0.71.0-0.5-0.5-0.81.9
Reaction time trials AUC0.31.04.60.40.5-0.81.0-0.4-0.5-1.02.1
Run reversals in cocaine runway, females1.21.43.2-1.8-1.71.0-0.81.21.0-1.1-0.1
Run reversals in cocaine runway, males0.60.71.20.50.5-1.10.7-0.8-1.01.1-0.7
Latency to leave start box in cocaine runway1.01.32.3-1.1-0.81.5-1.01.30.9-1.50.7
Latency to leave start box in cocaine runway, F2.53.14.8-1.9-1.52.2-2.12.01.9-1.5-0.2
Latency to leave start box in cocaine runway, M0.70.72.60.40.4-0.51.1-0.3-0.8-0.71.6
Std. dev. time between licks in bursts0.30.61.30.70.8-0.90.8-1.1-0.40.70.4
Total sessions with >9 infusions0.70.91.80.91.1-1.31.0-0.7-1.3-0.00.7
Short access day 1 total inactive lever presses0.61.32.9-1.5-1.60.6-0.1-0.20.51.2-1.7
Short access day 10 total inactive lever presses0.21.32.7-1.4-1.60.9-0.3-0.10.81.3-1.6
Short access day 1 total infusions0.00.10.2-0.4-0.20.1-0.30.30.3-0.3-0.4
Short access day 10 total infusions0.10.10.4-0.2-0.0-0.40.5-0.6-0.30.3-0.1
Short access total infusions0.30.51.10.40.5-1.10.8-0.7-0.80.4-0.1
Short access day 1 locomotion0.20.30.9-0.5-0.40.00.30.2-0.1-0.90.9
Short access day 10 total locomotion0.10.31.2-0.3-0.10.1-0.3-0.0-0.30.7-1.1
Short access total locomotion0.00.10.3-0.00.2-0.20.2-0.1-0.60.10.0
One hour access (0.3 mA shock)0.91.03.1-1.0-1.10.7-0.51.10.7-1.70.9
Compulsive drug intake0.20.30.90.40.0-0.90.9-0.6-0.30.40.4
One hour access (shock baseline)0.41.01.8-0.8-0.61.2-1.21.20.8-1.3-0.0
Social response proportion1.62.03.9-1.1-0.92.0-1.81.71.5-1.1-0.3
Social responses0.70.91.5-0.8-0.31.2-1.21.01.1-0.5-0.9
Social time0.20.30.5-0.30.10.7-0.70.60.7-0.70.4
Soleus weight1.95.713.60.90.4-2.32.0-3.1-2.23.7-2.8
Bone: stiffness1.22.25.8-0.7-0.41.5-1.31.91.3-2.41.1
Tibialis anterior weight3.712.620.04.34.5-4.22.8-3.7-4.02.5-0.1
Time to tail flick, vehicle, before self-admin1.11.43.0-1.2-1.11.0-0.71.50.9-1.70.7
Time to tail flick, vehicle, after self-admin0.51.13.7-1.9-1.70.8-0.20.10.70.4-0.8
Time to tail flick, test, before self-admin0.30.41.0-0.30.1-0.30.3-0.4-1.01.0-0.8
Time to tail flick, test, after self-admin1.41.52.7-1.6-1.21.3-1.31.60.8-1.20.0
Delta time to tail flick, vehicle, before/after SA0.30.31.5-0.5-0.20.2-0.2-0.20.10.6-1.2
Delta time to tail flick, test, before/after SA1.21.52.6-0.7-0.61.3-1.51.51.4-1.60.3
Tibia length0.20.71.2-0.3-0.60.8-1.11.11.0-1.0-0.1
Ambulatory time before self-admin0.10.20.6-0.4-0.30.1-0.2-0.20.30.6-0.7
Ambulatory time after self-admin1.62.67.3-2.7-2.51.6-0.81.01.7-0.3-0.1
Bone: tissue strength0.40.40.8-0.5-0.80.5-0.30.60.9-0.90.4
Total heroin consumption0.30.41.3-1.1-1.10.40.20.50.4-0.30.3
Bone: trabecular number0.10.30.80.7-0.2-0.40.10.4-0.2-0.90.6
Bone: trabecular spacing0.40.51.60.10.90.7-1.30.40.30.5-1.0
Bone: trabecular thickness0.20.31.4-0.6-1.2-0.10.20.20.1-0.50.1
Bone: trabecular tissue density0.30.61.81.11.3-0.40.10.0-0.4-0.51.1
Water consumed over 24 hours0.51.03.0-1.2-1.70.9-0.41.10.3-1.1-0.0
Number of responses in last shaping day0.00.10.10.30.3-0.0-0.3-0.2-0.20.2-0.4