Hub : Genes

Grin3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Grin3b 0.14 0.09 4.9e-07 0.11 0.11 0.11 0.12 1.4e-06 1.8e-06 1.9e-06 5.1e-07
2 NAcc gene expression Grin3b 0.17 0.1 0.0e+00 0.19 0.19 0.19 0.19 2.6e-21 2.2e-21 1.1e-21 9.6e-22
3 Adipose gene expression Grin3b 0.08 0.06 3.3e-09 0.07 0.07 0.07 0.07 1.0e-08 2.9e-08 3.0e-08 1.7e-08
4 LHb gene expression Grin3b 0.32 0.17 8.5e-07 0.24 0.21 0.22 0.23 2.3e-06 9.0e-06 6.8e-06 3.3e-06
5 pVTA gene expression Grin3b 0.1 0.07 1.6e-04 0.08 0.06 0.05 0.07 2.2e-04 1.1e-03 3.9e-03 8.5e-04
6 PL gene expression Grin3b 0.19 0.11 0.0e+00 0.19 0.22 0.22 0.22 8.6e-21 3.4e-24 2.7e-24 4.2e-24
7 OFC gene expression Grin3b 0.43 0.19 1.8e-07 0.26 0.23 0.25 0.27 6.6e-07 3.0e-06 1.3e-06 4.0e-07
8 Brain gene expression Grin3b 0.31 0.14 0.0e+00 0.15 0.17 0.17 0.17 3.8e-14 6.5e-16 6.0e-16 1.7e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.23.5-0.9-0.80.60.60.61.3-1.31.9
Area under the delay curve2.12.22.6-1.6-1.61.51.51.51.5-1.41.2
BMI with tail5.718.621.7-4.6-4.74.64.64.64.3-3.93.1
BMI without tail1.53.14.3-1.8-1.92.12.12.11.5-1.30.9
Body weight1.14.45.3-2.1-2.22.32.32.31.9-1.91.6
Weight adjusted by age0.10.20.2-0.5-0.40.40.40.40.20.0-0.4
Bone surface0.50.94.0-0.5-0.50.20.20.21.0-1.32.0
Bone volume0.61.04.1-0.6-0.50.30.30.31.1-1.32.0
Breakpoint value in progressive ratio session5.96.57.02.62.6-2.5-2.5-2.5-2.62.5-2.4
Number of licking bursts0.10.20.70.10.1-0.2-0.2-0.2-0.20.6-0.8
Context. condit. distance diff. score0.10.20.3-0.1-0.10.60.60.60.0-0.40.4
Locomotion velocity, session 10.10.10.20.40.3-0.5-0.5-0.5-0.1-0.00.3
Locomotion distance, session 10.40.52.90.20.10.10.10.10.4-1.01.7
Locomotion velocity, session 22.12.54.42.11.9-1.7-1.7-1.7-1.40.8-0.0
Locomotion distance, session 20.40.60.90.80.9-1.0-1.0-1.0-0.2-0.10.7
Locomotion velocity, session 36.98.09.63.13.1-2.9-2.9-2.9-2.82.7-2.3
Locomotion distance, session 30.00.00.10.30.2-0.0-0.0-0.0-0.20.2-0.2
Stereotopy head waving bouts, day 34.24.97.12.72.6-2.3-2.3-2.3-2.21.7-1.3
Stereotopy head waving duration, day 35.56.68.42.92.9-2.6-2.6-2.6-2.62.2-1.9
Locomotion velocity, session 70.70.81.61.31.2-0.7-0.7-0.7-1.00.8-0.5
Locomotion distance, session 70.00.00.1-0.00.00.20.20.2-0.10.3-0.3
Stereotopy head waving bouts, day 70.10.10.60.1-0.00.20.20.20.3-0.50.8
Stereotopy head waving duration, day 70.10.10.30.30.2-0.2-0.2-0.20.1-0.30.6
Locomotion velocity, session 80.30.40.90.90.8-0.4-0.4-0.4-0.1-0.30.9
Locomotion distance, session 80.10.10.30.60.5-0.2-0.2-0.2-0.3-0.20.6
Degree of sensitization distance0.40.40.5-0.5-0.50.70.70.70.5-0.60.6
Degree of sensitization stereotypy2.42.62.9-1.6-1.61.61.61.61.7-1.71.7
Conditioned locomotion0.60.71.0-1.0-1.00.90.90.90.9-0.40.2
Cocaine response after cond. corrected2.73.14.7-2.2-2.02.02.02.01.4-1.10.5
Cocaine response after cond. not corrected2.83.14.6-2.1-2.02.12.12.11.4-1.10.6
Cocaine response before conditioning0.30.40.80.90.8-0.6-0.6-0.6-0.60.5-0.2
Saline control response0.00.00.1-0.2-0.30.20.20.20.3-0.10.1
Bone: connectivity density0.91.43.2-1.1-1.00.80.80.81.3-1.31.8
Bone: cortical apparent density0.81.01.9-1.4-1.21.01.01.01.1-0.90.4
Bone: cortical area1.01.42.2-1.1-1.21.11.11.11.3-1.31.5
Bone: cortical porosity0.20.20.40.50.5-0.6-0.6-0.6-0.30.20.2
Bone: cortical porosity0.20.21.1-0.1-0.20.10.10.10.5-0.61.0
Bone: cortical thickness1.52.42.8-1.6-1.61.51.51.51.7-1.51.6
Bone: cortical thickness0.20.20.80.10.1-0.2-0.2-0.2-0.30.6-0.9
Bone: cortical tissue density0.50.71.4-1.2-1.00.80.80.80.9-0.70.2
Condit. Reinf. active minus inactive responses4.34.96.32.52.3-2.2-2.2-2.2-2.42.0-1.7
Condit. Reinf. active-inactive response ratio2.83.13.71.61.6-1.7-1.7-1.7-1.91.8-1.9
Condit. Reinf. active responses2.73.34.72.22.0-2.0-2.0-2.0-1.81.4-0.8
Condit. Reinf. inactive responses0.30.40.60.80.7-0.7-0.7-0.7-0.2-0.00.6
Incentive salience index mean1.72.03.41.81.6-1.5-1.5-1.5-1.51.0-0.5
Condit. Reinf. lever presses0.50.62.7-0.2-0.40.30.30.30.8-1.11.7
Condit. Reinf. active minus inactive responses2.83.44.61.61.6-1.9-1.9-1.9-1.62.1-2.1
Condit. Reinf. active-inactive response ratio0.50.51.6-0.10.1-0.7-0.7-0.7-0.31.0-1.3
Condit. Reinf. active responses2.23.03.51.61.6-1.8-1.8-1.8-1.51.9-1.9
Condit. Reinf. inactive responses1.01.31.91.41.3-1.1-1.1-1.1-1.11.0-0.9
Condit. Reinf. lever presses2.63.64.21.81.8-1.9-1.9-1.9-1.82.1-1.9
Condit. Reinf. lever reinforcers received1.92.63.61.41.4-1.7-1.7-1.7-1.31.8-1.9
Conditioned reinforcement - actives1.51.51.91.41.4-1.3-1.3-1.3-1.31.1-0.9
Conditioned reinforcement - inactives0.20.30.4-0.5-0.50.70.70.70.4-0.40.2
Conditioned locomotion6.37.68.62.82.9-2.9-2.9-2.9-2.72.6-2.1
Patch foraging indifference point 0 sec0.20.30.5-0.6-0.60.50.50.50.7-0.60.7
Patch foraging indifference point AUC0.80.91.00.90.9-1.0-1.0-1.0-0.90.9-0.9
Delay disc. indifference point, 0s delay9.910.812.8-3.2-3.23.13.13.13.5-3.53.6
Delay disc. indifference point, 16s delay0.10.10.1-0.4-0.30.40.40.40.2-0.3-0.0
Delay disc. indifference point, 2s delay6.26.97.6-2.7-2.72.62.62.62.8-2.52.6
Delay disc. indifference point, 24s delay0.70.70.9-0.9-0.90.90.90.90.7-0.70.3
Delay disc. indifference point, 4s delay0.91.01.1-1.0-1.01.01.01.01.1-1.00.9
Delay disc. indifference point, 8s delay0.70.81.1-1.0-1.00.90.90.90.9-0.60.5
Indifference point function ln k0.10.20.2-0.5-0.50.50.50.50.4-0.30.2
Indifference point function log k0.10.20.2-0.5-0.50.50.50.50.4-0.30.2
Patch foraging total patch changes 0 sec0.10.20.3-0.4-0.50.40.40.40.5-0.40.5
Patch foraging total patch changes 12 sec0.10.20.3-0.5-0.50.40.40.40.3-0.20.2
Patch foraging total patch changes 18 sec1.01.31.61.21.1-1.3-1.3-1.3-1.11.1-0.9
Patch foraging total patch changes 24 sec0.00.00.10.00.0-0.3-0.3-0.3-0.10.2-0.1
Patch foraging total patch changes 6 sec0.10.20.30.30.4-0.5-0.5-0.5-0.30.4-0.3
Patch foraging time to switch 0 sec2.23.45.9-1.4-1.41.81.81.81.7-2.32.4
Patch foraging water rate 0 sec0.40.61.90.40.4-0.5-0.5-0.5-0.71.2-1.4
Patch foraging water rate 12 sec0.40.51.0-1.0-1.00.80.80.80.50.0-0.5
Patch foraging water rate 18 sec1.31.85.40.70.8-1.0-1.0-1.0-1.31.9-2.3
Patch foraging water rate 24 sec0.30.42.2-0.1-0.0-0.1-0.1-0.1-0.41.1-1.5
Patch foraging water rate 6 sec1.01.53.30.80.8-1.0-1.0-1.0-1.21.7-1.8
Seeking ratio, delayed vs. immediate footshock3.43.94.72.22.1-2.1-2.1-2.1-1.91.7-1.5
Distance traveled before self-admin0.80.81.1-1.0-0.90.90.90.90.9-1.00.9
Distance traveled after self-admin0.30.30.40.60.6-0.6-0.6-0.6-0.60.3-0.3
Extensor digitorum longus weight3.313.216.7-3.6-3.94.14.14.13.3-3.12.5
Bone: elastic displacement0.10.10.20.10.3-0.4-0.4-0.4-0.30.3-0.4
Bone: elastic work0.30.40.7-0.8-0.70.60.60.60.6-0.60.5
Bone: endosteal estimation0.20.40.5-0.4-0.60.70.70.70.4-0.70.6
Bone: endosteal perimeter0.10.30.50.70.6-0.5-0.5-0.5-0.50.30.0
Epididymis fat weight0.40.91.00.90.9-1.0-1.0-1.0-0.91.0-0.9
Delta time in closed arm before/after self-admin0.20.20.6-0.4-0.40.40.40.40.00.3-0.8
Delta time in open arm before/after self-admin1.31.31.6-1.3-1.21.11.11.11.2-1.21.1
Diff in mean of infusions in LGA sessions2.02.22.51.51.6-1.5-1.5-1.5-1.51.4-1.2
Delay discount exponential model param1.92.02.41.51.5-1.4-1.4-1.4-1.41.3-1.1
Extinction: sum of active levers before priming1.51.51.81.21.3-1.1-1.1-1.1-1.31.3-1.3
Active lever presses in extinction session 61.71.71.91.31.4-1.4-1.4-1.4-1.31.1-1.0
Bone: final force1.52.52.9-1.4-1.61.51.51.51.6-1.61.7
Bone: final moment1.21.92.2-1.3-1.41.41.41.41.4-1.41.5
Food consumed during 24 hour testing period0.30.40.6-0.8-0.70.70.70.70.5-0.50.1
Glucose1.32.02.7-1.7-1.61.41.41.41.6-1.20.9
Heart weight0.50.71.40.50.4-0.8-0.8-0.8-0.71.0-1.2
Delay discount hyperbolic model param2.72.93.41.81.8-1.7-1.7-1.7-1.71.6-1.4
Intermittent access intake day 1-15 change6.46.37.62.82.7-2.5-2.5-2.5-2.62.4-2.1
Intermittent access intake escalation7.27.07.82.82.7-2.6-2.6-2.6-2.72.7-2.6
Intermittent access intake escalation 28.68.59.03.03.0-2.9-2.9-2.9-3.03.0-2.8
Intermitt. access day 1 inactive lever presses0.30.30.60.50.5-0.4-0.4-0.4-0.60.7-0.8
Intermitt. access day 15 inactive lever presses0.60.70.80.90.9-0.8-0.8-0.8-0.80.8-0.8
Intermitt. access escalation Index0.80.71.2-0.6-0.60.80.80.80.8-1.11.0
Intermittent access day 1 total infusions0.00.10.1-0.3-0.30.10.10.10.3-0.20.3
Intermittent access day 15 total infusions2.22.52.61.61.6-1.6-1.6-1.6-1.61.6-1.5
Intermittent access terminal intake (last 3 days)0.91.01.21.11.1-1.0-1.0-1.0-1.01.0-0.8
Intermittent access total infusions0.20.30.30.50.5-0.5-0.5-0.5-0.50.5-0.5
Intermittent access day 1 locomotion0.50.50.60.70.8-0.7-0.7-0.7-0.70.7-0.7
Intermittent access day 15 total locomotion3.33.64.42.12.1-1.9-1.9-1.9-2.01.7-1.6
Intermittent access total locomotion0.70.81.11.01.0-0.9-0.9-0.9-0.90.7-0.6
Intermittent access standard deviation3.03.23.51.81.8-1.7-1.7-1.7-1.91.8-1.8
Left kidney weight0.00.00.10.1-0.00.10.10.1-0.1-0.40.3
Right kidney weight1.13.24.22.01.9-1.8-1.8-1.8-2.01.5-1.5
Cocaine induced anxiety0.10.10.20.40.4-0.4-0.4-0.4-0.1-0.10.4
Post-drug Anxiety0.10.10.20.50.4-0.5-0.5-0.5-0.2-0.00.3
Baseline Anxiety0.50.61.00.60.7-0.6-0.6-0.6-0.80.9-1.0
Tail length3.29.711.43.43.3-3.1-3.1-3.1-3.33.0-2.6
Length with tail1.55.36.82.62.5-2.4-2.4-2.4-2.42.0-1.5
Length without tail0.00.10.50.10.0-0.0-0.0-0.00.2-0.40.7
Times rat made contact with spout0.10.10.2-0.3-0.10.30.30.30.00.1-0.5
Lifetime Intake0.10.10.10.30.3-0.3-0.3-0.3-0.30.3-0.2
Liver weight, left1.72.83.2-1.7-1.81.81.81.81.6-1.51.3
Liver weight, right1.72.83.2-1.4-1.51.81.81.81.5-1.81.7
Locomotor activity1.82.83.81.91.8-1.9-1.9-1.9-1.51.3-0.6
Locomotor testing distance1.22.02.81.51.4-1.7-1.7-1.7-1.31.3-0.7
Locomotor testing rearing0.10.20.40.20.1-0.3-0.3-0.3-0.30.6-0.6
Locomotion in novel chamber0.30.30.80.50.5-0.5-0.5-0.5-0.60.6-0.9
Locomotion in novel chamber post-restriction1.21.51.71.31.3-1.2-1.2-1.2-1.31.2-1.2
Fecal boli incidents, locomotor time 11.82.02.7-1.3-1.21.71.71.71.2-1.51.0
Change in fecal boli incidents, locomotor task0.00.00.10.30.2-0.1-0.1-0.1-0.1-0.00.0
Time >=10cm from walls, locomotor time 11.61.62.2-1.2-1.21.21.21.21.3-1.51.4
Bouts of movement, locomotor time 10.30.30.70.80.7-0.4-0.4-0.4-0.60.5-0.5
Total resting periods, locomotor time 10.30.30.70.90.8-0.4-0.4-0.4-0.70.4-0.5
Rest time, locomotor task time 10.30.31.01.00.9-0.4-0.4-0.4-0.60.2-0.1
Distance moved, locomotor task time 11.41.51.9-1.4-1.31.11.11.11.3-1.31.2
Vertical activity count, locomotor time 10.20.20.7-0.9-0.60.30.30.30.3-0.0-0.4
Time >=10cm from walls, locomotor time 21.21.31.6-1.3-1.31.21.21.21.2-0.90.8
Bouts of movement, locomotor time 20.20.30.50.50.5-0.7-0.7-0.7-0.30.20.1
Total resting periods, locomotor time 20.20.20.40.50.4-0.7-0.7-0.7-0.30.20.2
Rest time, locomotor task time 20.30.40.60.80.7-0.7-0.7-0.7-0.60.4-0.2
Distance moved, locomotor task time 20.40.50.7-0.8-0.80.80.80.80.7-0.50.5
Vertical activity count, locomotor time 20.30.30.6-0.8-0.60.70.70.70.5-0.20.1
Light reinforcement 14.58.29.83.13.1-3.1-3.1-3.1-2.82.5-1.9
Light reinforcement 21.41.92.31.41.5-1.5-1.5-1.5-1.31.1-0.9
Bone: marrow area0.20.40.5-0.4-0.60.70.70.70.4-0.70.6
Bone: maximum diameter0.30.50.90.90.8-0.8-0.8-0.8-0.60.40.0
Bone: maximum force1.32.22.5-1.4-1.61.51.51.51.4-1.51.5
Bone: maximum moment1.01.82.1-1.3-1.41.41.41.41.3-1.31.3
Mean time between licks in bursts4.36.06.62.52.4-2.6-2.6-2.6-2.32.5-2.2
Mean num. licks in bursts0.10.10.2-0.2-0.10.40.40.40.1-0.40.3
Cd content in liver0.40.41.0-0.8-0.80.50.50.51.0-0.50.6
Co content in liver0.60.60.80.90.8-0.9-0.9-0.9-0.70.8-0.6
Cu content in liver0.50.51.3-0.5-0.60.60.60.60.9-0.91.2
Fe content in liver0.10.20.50.70.6-0.3-0.3-0.3-0.40.4-0.1
K content in liver0.40.41.70.2-0.20.30.30.30.6-0.71.3
Mg content in liver0.40.41.5-0.1-0.30.40.40.40.7-0.81.2
Mn content in liver0.40.41.10.90.8-0.5-0.5-0.5-0.2-0.31.1
Na content in liver1.81.94.6-0.8-1.01.21.21.21.4-1.52.2
Rb content in liver0.91.22.2-0.8-0.90.90.90.91.2-1.31.5
Se content in liver0.20.30.91.00.8-0.4-0.4-0.4-0.60.30.1
Sr content in liver0.20.20.60.20.3-0.3-0.3-0.3-0.50.6-0.7
Zn content in liver3.33.65.71.61.6-1.8-1.8-1.8-2.02.2-2.4
Bone: minimum diameter0.00.10.40.1-0.10.20.20.20.1-0.40.6
Time in familiar zone, hab. session 13.23.03.41.61.8-1.7-1.7-1.7-1.91.8-1.7
Time in novel zone, hab. session 12.01.92.3-1.2-1.41.31.31.31.5-1.51.5
Total zone transitions, hab. session 10.30.50.90.90.8-0.8-0.8-0.8-0.40.10.4
Total locomotion distance, hab. session 10.40.61.21.11.0-0.7-0.7-0.7-0.3-0.20.9
Locomotion velocity, hab. session 10.71.02.01.41.3-1.0-1.0-1.0-0.60.10.6
Time in familiar zone, hab. session 27.88.19.12.72.8-2.8-2.8-2.8-3.02.9-3.0
Time in novel zone, hab. session 25.85.86.3-2.4-2.42.42.42.42.5-2.52.2
Total zone transitions, hab. session 21.01.33.4-0.7-0.80.70.70.71.2-1.61.8
Total locomotion distance, hab. session 20.40.50.80.90.7-0.8-0.8-0.8-0.50.10.2
Locomotion velocity, hab. session 20.30.40.70.80.6-0.7-0.7-0.7-0.3-0.20.5
Novel to familiar place preference ratio6.16.37.1-2.4-2.42.42.42.42.6-2.72.6
Novelty place preference3.94.04.8-1.9-1.91.91.91.92.1-2.22.2
Time in novel zone, NPP test4.14.35.0-1.9-2.02.02.02.02.1-2.22.2
Total zone transitions, NPP test0.30.41.4-0.3-0.30.20.20.20.7-0.91.2
Total locomotion distance, NPP test0.40.52.0-0.2-0.30.40.40.40.7-1.01.4
Locomotion velocity, NPP test0.20.31.30.0-0.10.10.10.10.5-0.81.2
Intraocular pressure0.40.62.20.10.4-0.5-0.5-0.5-0.71.0-1.5
Delta distance traveled before/after self-admin1.51.72.21.51.5-1.3-1.3-1.3-1.31.1-0.9
Delta ambulatory time before/after self-admin1.61.72.41.51.5-1.4-1.4-1.4-1.31.1-0.8
Parametrial fat weight0.40.91.20.91.0-0.8-0.8-0.8-1.11.0-0.9
Pavlov. Cond. lever latency0.30.31.7-0.2-0.0-0.3-0.3-0.3-0.30.7-1.3
Pavlov. Cond. magazine entry latency3.54.56.32.52.4-2.1-2.1-2.1-2.31.9-1.5
Pavlov. Cond. change in total contacts0.10.20.50.70.5-0.2-0.2-0.2-0.40.10.3
Pavlov. Cond. index score0.40.51.41.21.0-0.6-0.6-0.6-0.80.20.3
Pavlov. Cond. latency score0.30.41.31.10.9-0.5-0.5-0.5-0.60.00.7
Pavlov. Cond. lever contacts0.20.31.60.40.20.10.10.10.2-0.71.3
Pavlov. Cond. magazine entry number0.91.22.0-1.4-1.31.01.01.01.2-0.90.5
Pavlov. Cond. intertrial magazine entries0.40.51.20.40.4-0.6-0.6-0.6-0.60.9-1.1
Pavlov. Cond. lever-magazine prob. diff.0.70.92.11.41.3-0.9-0.9-0.9-1.00.50.0
Pavlov. Cond. response bias1.31.62.81.71.5-1.2-1.2-1.2-1.41.0-0.5
Pavlov. Cond. lever latency0.60.81.0-0.8-0.81.01.01.00.8-1.00.8
Pavlov. Cond. magazine entry latency0.40.50.80.90.8-0.6-0.6-0.6-0.90.6-0.5
Pavlov. Cond. change in total contacts0.70.91.30.70.8-1.1-1.1-1.1-0.71.1-1.0
Pavlov. Cond. index score0.81.01.11.01.0-1.0-1.0-1.0-1.01.1-0.9
Pavlov. Cond. latency score0.60.70.80.90.9-0.9-0.9-0.9-0.80.9-0.7
Pavlov. Cond. lever contacts0.81.01.40.90.9-1.0-1.0-1.0-0.91.2-1.1
Pavlov. Cond. magazine entry number0.70.81.2-1.1-1.00.90.90.91.0-0.80.6
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.4-0.50.40.40.40.4-0.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.70.91.01.01.0-1.0-1.0-1.0-0.91.0-0.8
Pavlov. Cond. response bias1.92.53.01.51.5-1.6-1.6-1.6-1.51.7-1.6
Time in closed arm before self-admin1.41.62.9-1.1-1.11.11.11.11.3-1.51.7
Time in closed arm after self-admin0.00.00.10.20.2-0.2-0.2-0.2-0.20.2-0.2
Time in open arm before self-admin0.80.81.01.00.9-0.9-0.9-0.9-0.91.0-0.9
Time in open arm after self-admin0.60.71.0-1.0-1.00.80.80.80.8-0.70.6
Bone: periosteal estimation0.51.01.6-0.8-0.91.01.01.00.9-1.21.3
Bone: periosteal perimeter0.00.10.50.10.0-0.1-0.1-0.10.2-0.30.7
Bone: post-yield work0.30.40.6-0.4-0.60.70.70.70.5-0.50.6
Progressive ratio test 1 active lever presses0.00.00.10.00.00.10.10.1-0.10.1-0.4
Progressive ratio test 1 breakpoint0.00.00.1-0.0-0.10.20.20.20.0-0.1-0.2
Progressive ratio test 1 inactive lever presses0.00.00.10.20.2-0.1-0.1-0.1-0.2-0.0-0.2
Progressive ratio test 2 active lever presses0.30.30.50.50.5-0.4-0.4-0.4-0.60.6-0.7
Progressive ratio test 2 breakpoint0.20.20.30.50.5-0.4-0.4-0.4-0.50.4-0.5
Progressive ratio test 2 inactive lever presses0.00.00.00.10.1-0.0-0.0-0.00.0-0.10.2
Incentive Sensitization - Responses0.20.20.40.30.4-0.2-0.2-0.2-0.50.5-0.6
Incentive Sensitization - Breakpoint0.20.20.40.40.5-0.3-0.3-0.3-0.50.5-0.6
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.10.10.10.10.1-0.20.2
Progressive ratio0.00.00.1-0.1-0.20.30.30.3-0.0-0.20.2
Food seeking constrained by brief footshock0.20.20.60.80.7-0.4-0.4-0.4-0.50.10.1
Seeking ratio, punishment vs. effort0.10.10.20.40.4-0.4-0.4-0.4-0.10.10.1
Retroperitoneal fat weight0.10.50.7-0.6-0.70.80.80.80.4-0.70.4
Reaction time number correct0.10.20.6-0.4-0.40.40.40.40.10.2-0.8
Reaction time mean minus median0.81.01.21.00.9-1.0-1.0-1.0-1.01.1-1.0
Reaction time mean minus median AUC0.10.10.4-0.0-0.10.10.10.10.2-0.40.6
Reaction time num false alarms0.00.10.2-0.0-0.10.10.10.1-0.10.4-0.4
Reaction time num false alarms AUC0.00.10.3-0.0-0.10.10.10.1-0.10.5-0.5
Reaction time trials correct on left0.10.20.6-0.4-0.40.40.40.40.10.2-0.8
Reaction time trials on left0.10.20.5-0.5-0.40.50.50.50.20.2-0.7
Reaction time mean0.10.10.1-0.3-0.30.20.20.20.3-0.30.3
Reaction time mean AUC0.10.10.2-0.5-0.50.30.30.30.4-0.40.4
Median of all reaction times0.50.70.8-0.9-0.80.70.70.70.8-0.90.8
Reaction time omissions0.10.10.20.20.3-0.4-0.4-0.4-0.30.2-0.5
Reaction time false alarm rate0.00.00.1-0.0-0.10.10.10.10.1-0.00.3
Reaction time premature initiation rate1.52.02.61.11.2-1.4-1.4-1.4-1.31.6-1.6
Reaction time premature initiations1.52.14.61.01.1-1.3-1.3-1.3-1.41.8-2.1
Std. dev. reaction times0.10.20.20.40.4-0.5-0.5-0.5-0.50.5-0.4
Reaction time trials completed0.10.20.5-0.5-0.40.50.50.50.20.2-0.7
Reaction time trials AUC0.10.20.9-0.4-0.30.40.40.40.00.3-0.9
Run reversals in cocaine runway, females0.40.40.60.80.7-0.6-0.6-0.6-0.70.4-0.3
Run reversals in cocaine runway, males1.21.21.51.11.2-1.2-1.2-1.2-1.10.9-0.7
Latency to leave start box in cocaine runway0.10.10.30.10.2-0.5-0.5-0.50.3-0.00.3
Latency to leave start box in cocaine runway, F1.11.22.5-1.1-1.00.70.70.71.5-1.31.6
Latency to leave start box in cocaine runway, M3.83.74.11.91.9-1.9-1.9-1.9-1.92.0-2.0
Std. dev. time between licks in bursts0.40.50.70.80.7-0.8-0.8-0.8-0.40.6-0.4
Total sessions with >9 infusions0.10.10.2-0.3-0.30.30.30.30.4-0.40.5
Short access day 1 total inactive lever presses0.00.00.10.30.3-0.2-0.2-0.2-0.20.0-0.1
Short access day 10 total inactive lever presses0.00.00.1-0.0-0.0-0.2-0.2-0.2-0.10.3-0.1
Short access day 1 total infusions0.00.00.10.30.2-0.1-0.1-0.1-0.0-0.20.3
Short access day 10 total infusions0.10.20.40.40.4-0.3-0.3-0.3-0.50.4-0.6
Short access total infusions0.00.00.0-0.0-0.10.10.10.10.1-0.10.2
Short access day 1 locomotion0.50.50.80.90.9-0.8-0.8-0.8-0.70.4-0.4
Short access day 10 total locomotion3.94.34.72.22.2-2.1-2.1-2.1-2.12.0-1.9
Short access total locomotion0.60.60.80.90.9-0.8-0.8-0.8-0.80.7-0.5
One hour access (0.3 mA shock)0.10.10.1-0.3-0.30.30.30.30.3-0.20.2
Compulsive drug intake1.81.82.0-1.4-1.41.31.31.31.4-1.31.4
One hour access (shock baseline)0.30.40.70.60.6-0.5-0.5-0.5-0.70.7-0.8
Social response proportion0.30.30.60.60.6-0.7-0.7-0.7-0.30.3-0.1
Social responses5.06.47.82.82.7-2.8-2.8-2.8-2.42.2-1.5
Social time0.71.01.4-1.1-1.10.90.90.91.2-0.91.0
Soleus weight8.224.027.0-5.2-5.25.25.25.24.8-4.43.8
Bone: stiffness3.04.75.1-1.9-2.22.32.32.32.1-2.12.2
Tibialis anterior weight1.03.54.3-1.7-1.92.12.12.11.7-1.81.6
Time to tail flick, vehicle, before self-admin0.10.20.30.30.4-0.5-0.5-0.5-0.20.10.2
Time to tail flick, vehicle, after self-admin0.60.71.20.70.7-0.7-0.7-0.7-0.81.1-1.0
Time to tail flick, test, before self-admin0.00.00.20.10.1-0.2-0.2-0.20.0-0.20.4
Time to tail flick, test, after self-admin0.30.30.50.60.5-0.7-0.7-0.7-0.40.4-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.0-0.10.20.20.2-0.10.4-0.5
Delta time to tail flick, test, before/after SA0.60.60.80.80.7-0.6-0.6-0.6-0.80.9-0.9
Tibia length0.92.62.91.71.6-1.7-1.7-1.7-1.71.6-1.4
Ambulatory time before self-admin0.70.70.9-1.0-0.90.80.80.80.8-0.90.8
Ambulatory time after self-admin0.10.10.20.40.5-0.4-0.4-0.4-0.40.2-0.2
Bone: tissue strength2.12.02.3-1.5-1.51.41.41.41.5-1.41.3
Total heroin consumption1.82.12.41.51.5-1.5-1.5-1.5-1.41.3-1.1
Bone: trabecular number0.20.30.40.60.6-0.6-0.6-0.6-0.20.10.5
Bone: trabecular spacing0.20.31.7-0.1-0.10.10.10.1-0.40.7-1.3
Bone: trabecular thickness1.51.85.6-1.1-1.00.70.70.71.6-1.72.4
Bone: trabecular tissue density1.01.41.7-1.2-1.31.31.31.31.1-1.00.8
Water consumed over 24 hours0.81.01.2-0.9-0.91.01.01.01.1-1.11.0
Number of responses in last shaping day0.10.10.10.30.4-0.2-0.2-0.2-0.30.2-0.2