Hub : Genes

Grin3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Grin3b 0.02 0.01 7.1e-04 0.01 0.01 0.01 0 2.4e-02 2.4e-02 1.4e-02 5.3e-02
2 IC gene expression Grin3b 0.13 0.08 6.6e-05 0.05 0.06 0.03 0.05 5.2e-03 2.2e-03 1.8e-02 3.3e-03
3 BLA gene expression Grin3b 0.13 0.09 3.5e-07 0.14 0.12 0.13 0.13 8.3e-08 1.0e-06 1.6e-07 2.6e-07
4 NAcc gene expression Grin3b 0.22 0.18 0.0e+00 0.2 0.2 0.2 0.2 1.2e-29 9.2e-29 9.0e-29 5.2e-29
5 pVTA gene expression Grin3b 0.12 0.08 6.2e-11 0.12 0.13 0.12 0.13 7.5e-10 2.5e-10 9.1e-10 8.8e-11
6 IL gene expression Grin3b 0.13 0.1 8.9e-03 0.04 0.03 0.01 0.03 4.4e-02 6.4e-02 2.3e-01 7.2e-02
7 Adipose gene expression Grin3b 0.08 0.06 4.3e-09 0.07 0.07 0.06 0.07 1.0e-08 2.7e-08 2.3e-07 1.5e-08
8 LHb gene expression Grin3b 0.33 0.17 9.5e-07 0.23 0.2 0.21 0.22 3.0e-06 1.7e-05 1.0e-05 5.0e-06
9 PL gene expression Grin3b 0.19 0.11 0.0e+00 0.21 0.22 0.22 0.22 1.9e-22 4.6e-24 5.6e-24 1.4e-23
10 Brain gene expression Grin3b 0.33 0.14 0.0e+00 0.17 0.18 0.18 0.19 7.6e-16 5.0e-17 5.6e-17 2.5e-17
11 OFC gene expression Grin3b 0.47 0.19 4.7e-07 0.13 0.18 0.22 0.22 6.8e-04 4.1e-05 6.7e-06 4.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.92.60.1-0.41.01.0-0.90.70.70.7-1.3-1.3-1.6
Area under the delay curve1.52.33.01.7-1.61.61.6-1.71.41.41.4-1.4-1.4-1.1
BMI with tail5.820.423.84.9-4.94.64.6-4.54.74.74.7-4.2-4.1-3.5
BMI without tail0.95.06.82.6-2.52.22.2-2.22.42.42.4-1.9-1.9-1.4
Body weight0.93.94.52.1-2.12.02.0-2.02.12.12.1-1.8-1.9-1.6
Weight adjusted by age0.10.30.80.9-0.80.60.6-0.50.70.70.7-0.3-0.3-0.1
Bone surface0.30.63.1-0.70.30.50.5-0.40.30.30.3-1.1-1.1-1.7
Bone volume0.40.73.2-0.50.10.70.7-0.60.30.30.3-1.2-1.2-1.8
Breakpoint value in progressive ratio session2.64.64.9-2.22.2-2.1-2.12.2-2.2-2.2-2.22.22.11.9
Number of licking bursts0.10.20.90.3-0.2-0.1-0.10.1-0.3-0.3-0.30.40.51.0
Context. condit. distance diff. score0.20.20.50.5-0.40.10.1-0.50.70.70.7-0.2-0.6-0.4
Locomotion velocity, session 10.20.20.7-0.80.7-0.3-0.30.4-0.4-0.4-0.40.0-0.1-0.4
Locomotion distance, session 10.30.31.7-0.80.6-0.3-0.3-0.10.10.10.1-0.5-0.8-1.3
Locomotion velocity, session 22.83.36.6-2.62.4-2.2-2.21.8-1.7-1.7-1.71.30.90.2
Locomotion distance, session 20.81.13.1-1.81.5-0.9-0.91.0-1.1-1.1-1.10.30.2-0.5
Locomotion velocity, session 36.97.99.6-2.82.9-3.1-3.12.8-2.7-2.7-2.72.92.62.3
Locomotion distance, session 30.00.00.10.00.1-0.3-0.30.2-0.0-0.0-0.00.30.20.3
Stereotopy head waving bouts, day 35.06.07.4-2.72.7-2.7-2.72.4-2.5-2.5-2.52.22.01.6
Stereotopy head waving duration, day 36.27.78.9-3.03.0-2.9-2.92.7-2.9-2.9-2.92.52.52.0
Locomotion velocity, session 70.60.71.7-0.60.8-1.3-1.30.6-0.5-0.5-0.50.90.60.7
Locomotion distance, session 70.10.10.40.6-0.50.00.0-0.30.30.30.30.10.10.4
Stereotopy head waving bouts, day 70.10.10.4-0.20.10.10.1-0.20.00.00.0-0.4-0.4-0.6
Stereotopy head waving duration, day 70.20.20.6-0.70.6-0.4-0.40.3-0.5-0.5-0.5-0.0-0.0-0.4
Locomotion velocity, session 80.40.51.1-1.00.9-1.0-1.00.4-0.4-0.4-0.40.2-0.2-0.6
Locomotion distance, session 80.10.20.5-0.70.6-0.6-0.60.3-0.2-0.2-0.20.2-0.2-0.4
Degree of sensitization distance0.50.50.70.7-0.70.50.5-0.80.80.80.8-0.6-0.8-0.7
Degree of sensitization stereotypy1.92.12.61.3-1.41.51.5-1.41.41.41.4-1.6-1.5-1.5
Conditioned locomotion0.60.82.01.4-1.20.80.8-0.90.80.80.8-0.5-0.4-0.0
Cocaine response after cond. corrected2.94.47.82.8-2.62.32.3-2.12.12.12.1-1.6-1.4-0.7
Cocaine response after cond. not corrected3.14.48.02.8-2.72.32.3-2.12.12.12.1-1.6-1.4-0.7
Cocaine response before conditioning0.50.60.9-0.90.9-1.0-1.00.7-0.7-0.7-0.70.70.60.4
Saline control response0.10.10.30.5-0.40.30.3-0.20.20.20.2-0.1-0.10.1
Bone: connectivity density0.71.12.10.4-0.61.11.1-1.10.90.90.9-1.3-1.3-1.5
Bone: cortical apparent density0.91.52.31.2-1.31.51.5-1.21.11.11.1-1.2-1.0-0.9
Bone: cortical area0.61.01.60.7-0.80.90.9-1.11.01.01.0-1.2-1.2-1.3
Bone: cortical porosity0.00.00.1-0.40.3-0.1-0.10.1-0.2-0.2-0.2-0.1-0.2-0.3
Bone: cortical porosity0.20.20.8-0.10.00.20.2-0.30.20.20.2-0.6-0.7-0.9
Bone: cortical thickness1.42.32.71.3-1.41.51.5-1.61.51.51.5-1.7-1.6-1.6
Bone: cortical thickness0.20.20.80.10.0-0.2-0.20.3-0.3-0.3-0.30.50.70.9
Bone: cortical tissue density0.61.01.81.0-1.11.31.3-0.90.90.90.9-1.0-0.8-0.8
Condit. Reinf. active minus inactive responses4.75.36.1-2.52.5-2.5-2.52.4-2.3-2.3-2.32.32.11.8
Condit. Reinf. active-inactive response ratio2.62.83.4-1.61.6-1.5-1.51.8-1.6-1.6-1.61.81.81.7
Condit. Reinf. active responses3.14.06.1-2.52.4-2.2-2.22.0-2.1-2.1-2.11.71.51.0
Condit. Reinf. inactive responses0.40.51.4-1.21.0-0.8-0.80.6-0.5-0.5-0.50.2-0.1-0.5
Incentive salience index mean2.02.64.0-2.01.9-1.9-1.91.7-1.5-1.5-1.51.41.20.7
Condit. Reinf. lever presses0.20.31.8-0.40.20.10.1-0.30.30.30.3-0.7-0.9-1.3
Condit. Reinf. active minus inactive responses2.23.34.6-1.41.5-1.6-1.61.8-1.9-1.9-1.91.92.12.1
Condit. Reinf. active-inactive response ratio0.20.41.50.10.00.10.10.5-0.7-0.7-0.70.50.91.2
Condit. Reinf. active responses2.23.13.6-1.51.6-1.7-1.71.8-1.9-1.9-1.91.81.91.8
Condit. Reinf. inactive responses1.01.52.3-1.11.2-1.5-1.51.1-1.1-1.1-1.11.31.10.9
Condit. Reinf. lever presses2.02.93.6-1.51.5-1.6-1.61.7-1.8-1.8-1.81.81.91.9
Condit. Reinf. lever reinforcers received1.82.63.5-1.21.3-1.5-1.51.6-1.7-1.7-1.71.71.81.9
Conditioned reinforcement - actives0.51.82.5-1.11.2-1.3-1.31.4-1.3-1.3-1.31.51.51.6
Conditioned reinforcement - inactives0.00.00.10.2-0.10.00.00.00.00.00.00.10.20.2
Conditioned locomotion5.78.49.7-3.13.1-2.8-2.82.9-3.1-3.1-3.12.72.72.4
Patch foraging indifference point 0 sec0.20.40.50.6-0.60.70.7-0.70.60.60.6-0.7-0.7-0.7
Patch foraging indifference point AUC0.51.11.3-1.01.0-0.9-0.91.1-1.1-1.1-1.11.01.11.0
Delay disc. indifference point, 0s delay9.510.712.82.8-3.03.33.3-3.33.23.23.2-3.6-3.6-3.5
Delay disc. indifference point, 16s delay0.10.20.30.5-0.40.50.5-0.50.40.40.4-0.4-0.3-0.4
Delay disc. indifference point, 2s delay6.67.37.92.6-2.72.72.7-2.82.72.72.7-2.8-2.8-2.5
Delay disc. indifference point, 24s delay0.50.71.21.1-1.01.01.0-0.90.80.80.8-0.7-0.6-0.4
Delay disc. indifference point, 4s delay1.11.21.51.1-1.11.01.0-1.21.11.11.1-1.1-1.1-1.0
Delay disc. indifference point, 8s delay0.61.12.11.4-1.31.01.0-1.30.90.90.9-0.9-0.8-0.4
Indifference point function ln k0.00.10.30.5-0.50.30.3-0.40.40.40.4-0.2-0.2-0.1
Indifference point function log k0.00.10.30.5-0.50.30.3-0.40.40.40.4-0.2-0.2-0.1
Patch foraging total patch changes 0 sec0.10.30.40.5-0.50.50.5-0.60.50.50.5-0.6-0.6-0.6
Patch foraging total patch changes 12 sec0.30.40.70.9-0.80.70.7-0.80.60.60.6-0.5-0.4-0.1
Patch foraging total patch changes 18 sec0.41.01.3-1.11.1-1.0-1.01.1-1.0-1.0-1.00.90.80.7
Patch foraging total patch changes 24 sec0.00.00.1-0.30.20.00.00.2-0.2-0.2-0.20.00.10.0
Patch foraging total patch changes 6 sec0.10.10.2-0.40.4-0.2-0.20.3-0.4-0.4-0.40.20.10.0
Patch foraging time to switch 0 sec0.72.85.51.0-1.11.41.4-1.71.71.71.7-1.9-2.1-2.3
Patch foraging water rate 0 sec0.10.42.00.3-0.1-0.5-0.50.5-0.4-0.4-0.40.91.01.4
Patch foraging water rate 12 sec0.20.82.21.5-1.40.90.9-0.70.80.80.8-0.4-0.10.4
Patch foraging water rate 18 sec0.61.45.60.20.1-0.7-0.70.8-0.9-0.9-0.91.51.82.4
Patch foraging water rate 24 sec0.30.52.31.1-0.70.10.1-0.10.00.00.00.60.81.5
Patch foraging water rate 6 sec0.81.34.0-0.20.4-0.8-0.80.9-1.1-1.1-1.11.31.62.0
Seeking ratio, delayed vs. immediate footshock2.84.05.2-2.32.2-2.1-2.12.0-2.1-2.1-2.11.91.71.3
Distance traveled before self-admin0.20.40.50.4-0.50.70.7-0.60.60.60.6-0.6-0.7-0.7
Distance traveled after self-admin0.00.00.0-0.10.00.10.1-0.00.00.00.0-0.1-0.1-0.1
Extensor digitorum longus weight3.313.219.14.4-4.23.43.4-3.93.93.93.9-3.1-3.1-2.3
Bone: elastic displacement0.10.10.2-0.30.20.10.10.4-0.4-0.4-0.40.20.40.2
Bone: elastic work0.50.60.90.7-0.81.01.0-0.70.70.70.7-0.8-0.7-0.7
Bone: endosteal estimation0.10.30.50.5-0.50.30.3-0.50.70.70.7-0.5-0.7-0.7
Bone: endosteal perimeter0.20.40.8-0.90.8-0.8-0.80.6-0.6-0.6-0.60.50.30.2
Epididymis fat weight0.00.21.00.00.1-0.3-0.30.4-0.3-0.3-0.30.60.71.0
Delta time in closed arm before/after self-admin0.30.31.11.0-0.80.30.3-0.30.30.30.30.20.40.9
Delta time in open arm before/after self-admin0.50.60.80.7-0.80.90.9-0.70.70.70.7-0.7-0.7-0.6
Diff in mean of infusions in LGA sessions1.12.02.5-1.61.6-1.4-1.41.5-1.5-1.5-1.51.41.31.1
Delay discount exponential model param1.31.82.5-1.61.5-1.4-1.41.6-1.3-1.3-1.31.31.20.9
Extinction: sum of active levers before priming0.71.11.3-0.91.0-1.0-1.01.0-1.0-1.0-1.01.11.11.1
Active lever presses in extinction session 61.41.42.3-1.51.4-1.0-1.01.3-1.3-1.3-1.31.01.00.8
Bone: final force1.52.53.31.5-1.51.41.4-1.71.61.61.6-1.7-1.8-1.7
Bone: final moment1.32.12.81.3-1.41.31.3-1.61.41.41.4-1.5-1.7-1.5
Food consumed during 24 hour testing period0.30.60.91.0-0.90.80.8-0.80.70.70.7-0.6-0.6-0.4
Glucose2.64.15.22.3-2.32.22.2-2.02.02.02.0-1.9-1.8-1.4
Heart weight0.91.52.9-0.80.9-1.0-1.01.3-1.2-1.2-1.21.41.51.7
Delay discount hyperbolic model param2.63.44.1-2.02.0-1.9-1.92.0-1.8-1.8-1.81.81.71.4
Intermittent access intake day 1-15 change1.37.18.4-2.52.6-2.9-2.92.7-2.6-2.6-2.62.82.72.6
Intermittent access intake escalation1.26.47.5-2.42.4-2.7-2.72.5-2.4-2.4-2.42.62.62.4
Intermittent access intake escalation 23.25.46.1-2.32.3-2.5-2.52.3-2.2-2.2-2.22.42.42.2
Intermitt. access day 1 inactive lever presses0.00.51.3-0.10.2-0.8-0.80.6-0.4-0.4-0.40.90.91.1
Intermitt. access day 15 inactive lever presses0.10.40.7-0.80.8-0.7-0.70.7-0.7-0.7-0.70.60.50.4
Intermitt. access escalation Index0.51.72.90.8-1.01.31.3-1.21.41.41.4-1.3-1.5-1.7
Intermittent access day 1 total infusions0.10.40.9-0.30.4-0.4-0.40.6-0.6-0.6-0.60.70.81.0
Intermittent access day 15 total infusions1.74.14.5-1.92.0-2.1-2.12.0-2.0-2.0-2.02.12.12.0
Intermittent access terminal intake (last 3 days)1.52.63.2-1.61.6-1.8-1.81.6-1.6-1.6-1.61.61.61.5
Intermittent access total infusions1.11.31.5-1.11.1-1.2-1.21.2-1.1-1.1-1.11.21.21.2
Intermittent access day 1 locomotion1.52.73.5-1.31.4-1.6-1.61.7-1.7-1.7-1.71.81.81.9
Intermittent access day 15 total locomotion1.66.16.8-2.32.4-2.6-2.62.5-2.4-2.4-2.42.62.52.3
Intermittent access total locomotion2.73.33.8-1.71.7-1.9-1.91.9-1.8-1.8-1.81.91.91.7
Intermittent access standard deviation1.47.37.9-2.82.8-2.8-2.82.8-2.7-2.7-2.72.72.62.3
Left kidney weight0.00.20.50.2-0.0-0.7-0.70.2-0.0-0.0-0.00.60.40.6
Right kidney weight0.42.94.0-1.31.4-1.9-1.91.7-1.6-1.6-1.62.01.82.0
Cocaine induced anxiety0.30.82.0-1.41.3-0.9-0.90.9-0.9-0.9-0.90.50.4-0.1
Post-drug Anxiety0.70.82.1-1.41.3-0.9-0.90.9-0.9-0.9-0.90.50.3-0.1
Baseline Anxiety0.10.10.2-0.20.3-0.3-0.30.3-0.3-0.3-0.30.40.40.4
Tail length2.513.515.1-3.73.7-3.9-3.93.7-3.7-3.7-3.73.73.53.3
Length with tail2.08.710.3-3.03.0-3.2-3.22.9-2.9-2.9-2.93.02.82.6
Length without tail0.00.00.00.1-0.1-0.0-0.0-0.10.10.10.1-0.0-0.00.0
Times rat made contact with spout0.10.10.40.6-0.50.20.2-0.30.20.20.20.00.10.3
Lifetime Intake0.60.80.9-0.80.8-0.9-0.90.9-0.9-0.9-0.91.00.91.0
Liver weight, left0.71.21.61.3-1.31.21.2-1.01.11.11.1-1.0-1.0-0.8
Liver weight, right0.40.71.21.1-1.00.70.7-0.81.01.01.0-0.5-0.6-0.4
Locomotor activity1.93.04.9-2.22.1-1.9-1.91.5-1.9-1.9-1.91.31.30.9
Locomotor testing distance0.81.93.2-1.81.7-1.4-1.41.3-1.5-1.5-1.51.01.00.6
Locomotor testing rearing0.00.10.50.00.1-0.2-0.20.2-0.4-0.4-0.40.40.50.7
Locomotion in novel chamber0.91.21.4-1.01.0-1.0-1.01.1-1.2-1.2-1.21.11.11.0
Locomotion in novel chamber post-restriction0.82.43.1-1.41.4-1.8-1.81.6-1.5-1.5-1.51.61.51.5
Fecal boli incidents, locomotor time 10.92.22.91.4-1.41.31.3-1.51.71.71.7-1.3-1.5-1.5
Change in fecal boli incidents, locomotor task0.10.10.3-0.30.4-0.5-0.50.3-0.2-0.2-0.20.20.20.0
Time >=10cm from walls, locomotor time 11.11.42.50.7-0.91.21.2-1.11.11.11.1-1.4-1.4-1.6
Bouts of movement, locomotor time 10.50.71.5-0.60.7-1.2-1.20.6-0.6-0.6-0.60.90.70.7
Total resting periods, locomotor time 10.60.71.6-0.70.8-1.2-1.20.7-0.6-0.6-0.60.90.70.6
Rest time, locomotor task time 10.30.41.4-0.70.7-1.2-1.20.5-0.3-0.3-0.30.60.30.1
Distance moved, locomotor task time 10.61.82.61.0-1.11.51.5-1.21.21.21.2-1.5-1.5-1.6
Vertical activity count, locomotor time 10.10.51.30.8-0.81.11.1-0.50.40.40.4-0.5-0.2-0.0
Time >=10cm from walls, locomotor time 20.51.52.21.5-1.51.21.2-1.41.21.21.2-1.1-1.1-0.7
Bouts of movement, locomotor time 20.10.30.7-0.80.7-0.4-0.40.5-0.6-0.6-0.60.20.1-0.1
Total resting periods, locomotor time 20.10.20.7-0.80.7-0.3-0.30.4-0.6-0.6-0.60.10.0-0.1
Rest time, locomotor task time 20.30.61.0-1.00.9-0.9-0.90.7-0.8-0.8-0.80.60.50.3
Distance moved, locomotor task time 20.40.50.90.9-0.90.80.8-0.80.70.70.7-0.7-0.6-0.4
Vertical activity count, locomotor time 20.20.40.91.0-0.90.70.7-0.60.60.60.6-0.3-0.30.1
Light reinforcement 11.88.412.6-3.53.4-2.9-2.93.0-3.0-3.0-3.02.52.41.8
Light reinforcement 20.92.03.1-1.81.7-1.3-1.31.4-1.5-1.5-1.51.21.30.8
Bone: marrow area0.10.30.50.5-0.50.30.3-0.50.70.70.7-0.4-0.7-0.6
Bone: maximum diameter0.51.01.9-1.41.3-1.1-1.11.0-1.0-1.0-1.00.70.60.3
Bone: maximum force1.22.42.91.5-1.61.41.4-1.71.61.61.6-1.5-1.7-1.5
Bone: maximum moment1.12.02.41.4-1.41.31.3-1.51.41.41.4-1.4-1.6-1.4
Mean time between licks in bursts1.16.36.8-2.52.6-2.6-2.62.6-2.6-2.6-2.62.52.42.1
Mean num. licks in bursts0.00.10.30.1-0.20.30.3-0.20.40.40.4-0.3-0.4-0.6
Cd content in liver0.10.10.2-0.40.30.00.00.3-0.4-0.4-0.40.10.30.2
Co content in liver1.71.92.3-1.31.3-1.3-1.31.4-1.5-1.5-1.51.31.51.4
Cu content in liver0.10.10.3-0.60.5-0.4-0.40.1-0.2-0.2-0.2-0.1-0.2-0.4
Fe content in liver0.30.41.1-0.50.6-1.0-1.00.5-0.5-0.5-0.50.70.50.6
K content in liver0.10.10.4-0.20.2-0.2-0.2-0.20.10.10.1-0.3-0.4-0.6
Mg content in liver0.10.20.3-0.60.5-0.4-0.40.4-0.5-0.5-0.50.20.20.1
Mn content in liver0.80.82.1-1.51.3-1.1-1.10.8-0.8-0.8-0.80.50.2-0.3
Na content in liver1.21.42.60.8-0.80.80.8-1.31.21.21.2-1.4-1.5-1.6
Rb content in liver0.10.20.7-0.20.10.20.2-0.20.20.20.2-0.5-0.6-0.9
Se content in liver0.40.40.9-0.60.7-1.0-1.00.5-0.5-0.5-0.50.60.50.4
Sr content in liver0.00.00.10.1-0.1-0.0-0.00.0-0.0-0.0-0.00.10.20.3
Zn content in liver4.75.47.9-1.92.0-1.9-1.92.4-2.4-2.4-2.42.52.72.8
Bone: minimum diameter0.00.10.30.0-0.0-0.2-0.2-0.20.30.30.3-0.2-0.4-0.5
Time in familiar zone, hab. session 12.42.73.2-1.51.5-1.5-1.51.6-1.7-1.7-1.71.71.81.8
Time in novel zone, hab. session 11.61.72.61.0-1.11.21.2-1.21.31.31.3-1.4-1.5-1.6
Total zone transitions, hab. session 10.50.71.7-1.31.2-0.9-0.90.7-0.9-0.9-0.90.30.2-0.3
Total locomotion distance, hab. session 10.60.92.3-1.51.4-1.2-1.20.7-0.9-0.9-0.90.20.1-0.5
Locomotion velocity, hab. session 11.11.53.2-1.81.7-1.5-1.51.0-1.2-1.2-1.20.60.4-0.2
Time in familiar zone, hab. session 26.97.88.9-2.72.7-2.6-2.63.0-2.8-2.8-2.83.02.92.8
Time in novel zone, hab. session 25.35.86.62.3-2.42.32.3-2.52.42.42.4-2.6-2.5-2.4
Total zone transitions, hab. session 20.81.14.10.1-0.30.70.7-0.90.70.70.7-1.4-1.5-2.0
Total locomotion distance, hab. session 20.70.92.3-1.51.3-0.9-0.90.8-1.0-1.0-1.00.40.3-0.3
Locomotion velocity, hab. session 20.60.82.3-1.51.3-0.8-0.80.7-0.9-0.9-0.90.10.1-0.6
Novel to familiar place preference ratio4.86.27.72.1-2.32.42.4-2.42.52.52.5-2.6-2.7-2.8
Novelty place preference3.14.05.31.6-1.71.91.9-1.92.02.02.0-2.1-2.2-2.3
Time in novel zone, NPP test3.54.35.41.7-1.81.91.9-2.02.12.12.1-2.2-2.3-2.3
Total zone transitions, NPP test0.20.31.5-0.20.00.40.4-0.40.20.20.2-0.9-0.8-1.2
Total locomotion distance, NPP test0.20.31.4-0.20.10.10.1-0.40.20.20.2-0.8-0.8-1.2
Locomotion velocity, NPP test0.10.21.0-0.50.3-0.0-0.0-0.1-0.1-0.1-0.1-0.5-0.6-1.0
Intraocular pressure0.20.31.40.2-0.10.10.10.4-0.3-0.3-0.30.60.81.2
Delta distance traveled before/after self-admin0.40.50.6-0.70.7-0.8-0.80.7-0.7-0.7-0.70.70.70.7
Delta ambulatory time before/after self-admin0.30.50.6-0.70.7-0.8-0.80.6-0.6-0.6-0.60.60.60.5
Parametrial fat weight0.00.00.2-0.1-0.00.20.2-0.10.20.20.2-0.3-0.4-0.4
Pavlov. Cond. lever latency0.10.20.80.3-0.20.30.30.3-0.1-0.1-0.10.40.50.9
Pavlov. Cond. magazine entry latency3.64.66.3-2.32.3-2.5-2.52.1-2.1-2.1-2.12.11.81.6
Pavlov. Cond. change in total contacts0.10.20.6-0.40.4-0.8-0.80.1-0.2-0.2-0.20.30.1-0.0
Pavlov. Cond. index score0.50.71.6-1.11.0-1.3-1.30.6-0.7-0.7-0.70.60.40.1
Pavlov. Cond. latency score0.50.61.4-1.11.0-1.2-1.20.5-0.6-0.6-0.60.40.2-0.1
Pavlov. Cond. lever contacts0.10.10.7-0.30.2-0.3-0.3-0.30.10.10.1-0.4-0.5-0.8
Pavlov. Cond. magazine entry number1.21.52.41.3-1.31.51.5-1.11.11.11.1-1.2-1.0-0.9
Pavlov. Cond. intertrial magazine entries0.30.41.0-0.20.3-0.3-0.30.5-0.6-0.6-0.60.70.91.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.8-1.21.1-1.4-1.40.7-0.8-0.8-0.80.80.50.3
Pavlov. Cond. response bias1.11.42.5-1.31.3-1.6-1.61.1-1.1-1.1-1.11.21.00.8
Pavlov. Cond. lever latency0.70.91.20.8-0.80.90.9-1.01.01.01.0-0.9-1.0-1.1
Pavlov. Cond. magazine entry latency0.40.50.7-0.70.7-0.8-0.80.7-0.6-0.6-0.60.70.70.7
Pavlov. Cond. change in total contacts0.30.81.4-0.60.7-0.7-0.70.9-1.0-1.0-1.00.91.11.2
Pavlov. Cond. index score0.50.91.2-0.70.8-0.9-0.90.9-1.0-1.0-1.00.91.01.1
Pavlov. Cond. latency score0.50.80.9-0.80.8-0.8-0.80.9-0.9-0.9-0.90.90.91.0
Pavlov. Cond. lever contacts0.60.81.4-0.70.7-0.8-0.80.9-0.9-0.9-0.91.01.11.2
Pavlov. Cond. magazine entry number0.70.91.20.9-0.91.11.1-0.90.90.90.9-0.9-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.10.20.50.7-0.70.40.4-0.40.50.50.5-0.3-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.60.91.0-0.80.8-0.9-0.90.9-1.0-1.0-1.00.91.01.0
Pavlov. Cond. response bias1.72.33.1-1.21.3-1.4-1.41.5-1.6-1.6-1.61.61.71.8
Time in closed arm before self-admin0.50.81.80.5-0.60.80.8-0.90.90.90.9-1.1-1.2-1.3
Time in closed arm after self-admin0.30.30.6-0.30.4-0.6-0.60.5-0.5-0.5-0.50.70.70.8
Time in open arm before self-admin0.10.10.1-0.30.3-0.4-0.40.2-0.2-0.2-0.20.20.20.1
Time in open arm after self-admin1.01.11.31.1-1.11.11.1-1.01.01.01.0-1.0-0.9-0.8
Bone: periosteal estimation0.30.71.40.5-0.60.60.6-0.80.90.90.9-0.9-1.1-1.2
Bone: periosteal perimeter0.00.10.2-0.40.3-0.3-0.30.1-0.2-0.2-0.2-0.1-0.2-0.3
Bone: post-yield work0.30.61.01.0-0.90.40.4-0.90.90.90.9-0.6-0.7-0.5
Progressive ratio test 1 active lever presses0.20.41.0-0.20.3-0.6-0.60.6-0.5-0.5-0.50.80.81.0
Progressive ratio test 1 breakpoint0.20.40.9-0.20.3-0.6-0.60.6-0.5-0.5-0.50.80.81.0
Progressive ratio test 1 inactive lever presses0.20.60.8-0.70.7-0.8-0.80.8-0.6-0.6-0.60.90.80.7
Progressive ratio test 2 active lever presses0.40.61.6-0.30.4-0.7-0.70.7-0.7-0.7-0.71.01.11.2
Progressive ratio test 2 breakpoint0.60.71.7-0.40.5-0.7-0.70.8-0.7-0.7-0.71.11.11.3
Progressive ratio test 2 inactive lever presses0.00.10.2-0.50.4-0.4-0.40.4-0.4-0.4-0.40.40.40.3
Incentive Sensitization - Responses0.00.10.40.3-0.2-0.1-0.10.1-0.0-0.0-0.00.30.40.6
Incentive Sensitization - Breakpoint0.00.10.40.1-0.0-0.2-0.20.2-0.1-0.1-0.10.40.50.6
Sum of active levers in priming session hrs 5-60.00.00.10.1-0.20.30.3-0.20.20.20.2-0.2-0.2-0.2
Progressive ratio0.00.10.30.5-0.40.30.3-0.40.30.30.3-0.2-0.2-0.1
Food seeking constrained by brief footshock0.30.40.9-0.90.8-1.0-1.00.6-0.5-0.5-0.50.40.20.1
Seeking ratio, punishment vs. effort0.10.30.7-0.80.7-0.6-0.60.6-0.4-0.4-0.40.30.2-0.0
Retroperitoneal fat weight0.20.81.61.3-1.20.80.8-0.91.01.01.0-0.6-0.7-0.2
Reaction time number correct0.10.20.90.9-0.80.30.3-0.30.40.40.40.10.20.6
Reaction time mean minus median0.10.81.1-0.80.8-0.9-0.91.0-0.9-0.9-0.91.01.01.0
Reaction time mean minus median AUC0.00.10.3-0.1-0.00.00.0-0.00.20.20.2-0.3-0.4-0.5
Reaction time num false alarms0.10.10.50.7-0.50.10.1-0.30.20.20.20.10.30.6
Reaction time num false alarms AUC0.10.10.60.8-0.50.10.1-0.30.10.10.10.20.30.6
Reaction time trials correct on left0.10.20.90.9-0.80.30.3-0.30.40.40.40.10.20.6
Reaction time trials on left0.10.20.91.0-0.80.30.3-0.30.40.40.40.10.20.5
Reaction time mean0.10.10.20.2-0.30.40.4-0.30.30.30.3-0.4-0.4-0.4
Reaction time mean AUC0.10.20.30.3-0.40.50.5-0.40.40.40.4-0.5-0.4-0.5
Median of all reaction times0.40.70.90.7-0.70.90.9-0.80.80.80.8-0.9-0.9-0.9
Reaction time omissions0.00.10.2-0.50.30.00.00.3-0.1-0.1-0.1-0.0-0.1-0.4
Reaction time false alarm rate0.00.10.20.4-0.30.20.2-0.40.20.20.2-0.2-0.1-0.0
Reaction time premature initiation rate1.01.52.1-1.01.1-1.0-1.01.3-1.3-1.3-1.31.31.41.4
Reaction time premature initiations0.51.63.4-0.70.8-1.0-1.01.3-1.2-1.2-1.21.51.61.9
Std. dev. reaction times0.00.10.2-0.30.3-0.3-0.30.5-0.4-0.4-0.40.40.30.3
Reaction time trials completed0.10.20.91.0-0.80.30.3-0.30.40.40.40.10.20.5
Reaction time trials AUC0.10.30.91.0-0.80.30.3-0.30.30.30.30.20.30.7
Run reversals in cocaine runway, females0.40.50.8-0.90.9-0.8-0.80.7-0.7-0.7-0.70.60.40.2
Run reversals in cocaine runway, males1.51.72.6-1.61.5-1.4-1.41.4-1.3-1.3-1.31.11.00.8
Latency to leave start box in cocaine runway0.10.10.3-0.60.50.20.20.2-0.3-0.3-0.3-0.1-0.2-0.5
Latency to leave start box in cocaine runway, F0.70.92.60.2-0.41.11.1-0.60.70.70.7-1.2-1.3-1.6
Latency to leave start box in cocaine runway, M2.12.02.4-1.21.4-1.3-1.31.3-1.5-1.5-1.51.51.51.5
Std. dev. time between licks in bursts0.40.71.0-0.90.9-1.0-1.00.8-0.9-0.9-0.90.70.60.5
Total sessions with >9 infusions0.40.50.7-0.50.5-0.8-0.80.7-0.6-0.6-0.60.80.80.8
Short access day 1 total inactive lever presses0.20.50.6-0.70.7-0.7-0.70.8-0.6-0.6-0.60.80.70.5
Short access day 10 total inactive lever presses0.00.00.20.2-0.1-0.2-0.20.0-0.1-0.1-0.10.10.20.5
Short access day 1 total infusions0.20.50.6-0.80.7-0.8-0.80.8-0.6-0.6-0.60.70.60.5
Short access day 10 total infusions0.20.30.6-0.30.3-0.6-0.60.5-0.4-0.4-0.40.70.70.7
Short access total infusions0.30.50.6-0.60.6-0.7-0.70.7-0.7-0.7-0.70.80.70.8
Short access day 1 locomotion1.11.82.1-1.31.4-1.3-1.31.4-1.3-1.3-1.31.41.31.2
Short access day 10 total locomotion2.29.110.3-2.62.8-3.2-3.23.0-3.0-3.0-3.03.23.13.1
Short access total locomotion2.13.13.5-1.61.7-1.8-1.81.8-1.8-1.8-1.81.91.81.8
One hour access (0.3 mA shock)0.00.00.10.1-0.0-0.1-0.10.1-0.2-0.2-0.20.20.20.3
Compulsive drug intake1.32.03.01.1-1.21.41.4-1.51.21.21.2-1.7-1.7-1.7
One hour access (shock baseline)0.51.31.9-0.80.9-1.1-1.11.1-1.1-1.1-1.11.31.31.4
Social response proportion0.50.71.2-1.11.0-0.8-0.80.8-0.9-0.9-0.90.60.50.2
Social responses5.97.79.9-3.13.1-2.9-2.92.8-2.9-2.9-2.92.52.31.9
Social time0.40.60.90.7-0.80.90.9-0.80.60.60.6-0.9-0.8-0.6
Soleus weight8.023.627.15.2-5.24.94.9-5.05.05.05.0-4.6-4.5-3.8
Bone: stiffness2.34.25.12.1-2.01.71.7-2.32.22.22.2-2.1-2.2-1.9
Tibialis anterior weight0.93.03.82.0-1.91.41.4-1.91.91.91.9-1.6-1.7-1.4
Time to tail flick, vehicle, before self-admin0.00.00.1-0.40.3-0.0-0.00.2-0.2-0.2-0.20.10.0-0.1
Time to tail flick, vehicle, after self-admin0.51.12.4-0.50.7-1.0-1.00.9-0.9-0.9-0.91.21.31.6
Time to tail flick, test, before self-admin0.10.10.3-0.60.5-0.3-0.30.4-0.4-0.4-0.40.10.1-0.1
Time to tail flick, test, after self-admin0.20.20.4-0.40.4-0.6-0.60.4-0.4-0.4-0.40.40.40.3
Delta time to tail flick, vehicle, before/after SA0.10.10.70.4-0.3-0.2-0.2-0.00.00.00.00.40.50.8
Delta time to tail flick, test, before/after SA0.20.20.80.00.1-0.5-0.50.3-0.3-0.3-0.30.60.60.9
Tibia length0.92.52.9-1.51.5-1.6-1.61.5-1.7-1.7-1.71.51.61.5
Ambulatory time before self-admin0.10.40.50.5-0.50.70.7-0.60.60.60.6-0.6-0.6-0.7
Ambulatory time after self-admin0.00.00.1-0.0-0.10.20.2-0.10.10.10.1-0.2-0.2-0.3
Bone: tissue strength2.22.32.61.5-1.51.61.6-1.61.51.51.5-1.6-1.5-1.4
Total heroin consumption1.31.52.2-1.51.4-1.2-1.21.3-1.3-1.3-1.31.11.00.8
Bone: trabecular number0.10.20.8-0.90.8-0.4-0.40.3-0.4-0.4-0.40.10.0-0.3
Bone: trabecular spacing0.20.31.10.9-0.70.10.1-0.10.10.10.10.40.51.0
Bone: trabecular thickness1.01.44.5-0.0-0.41.11.1-1.00.70.70.7-1.6-1.6-2.1
Bone: trabecular tissue density0.81.42.01.4-1.41.11.1-1.31.21.21.2-1.1-1.1-0.8
Water consumed over 24 hours0.61.11.41.0-1.00.90.9-1.21.11.11.1-1.1-1.1-1.1
Number of responses in last shaping day1.72.22.8-1.41.4-1.6-1.61.6-1.4-1.4-1.41.71.61.5