Hub : Genes

Grin3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Grin3b 0.02 0.01 7.1e-04 0.01 0.01 0.01 0 2.4e-02 2.4e-02 1.4e-02 5.1e-02
2 IC gene expression Grin3b 0.13 0.08 6.6e-05 0.05 0.06 0.03 0.05 5.2e-03 2.2e-03 1.8e-02 3.1e-03
3 NAcc gene expression Grin3b 0.22 0.18 0.0e+00 0.2 0.2 0.2 0.2 1.2e-29 9.2e-29 9.1e-29 5.5e-29
4 BLA gene expression Grin3b 0.13 0.09 3.5e-07 0.14 0.12 0.13 0.13 8.3e-08 1.0e-06 1.6e-07 2.5e-07
5 pVTA gene expression Grin3b 0.12 0.08 6.2e-11 0.12 0.13 0.12 0.13 7.5e-10 2.5e-10 9.1e-10 8.9e-11
6 IL gene expression Grin3b 0.13 0.1 8.9e-03 0.04 0.03 0.01 0.03 4.4e-02 6.4e-02 2.3e-01 7.2e-02
7 Adipose gene expression Grin3b 0.08 0.06 4.3e-09 0.07 0.07 0.06 0.07 1.0e-08 2.7e-08 2.3e-07 1.4e-08
8 LHb gene expression Grin3b 0.33 0.17 9.5e-07 0.23 0.2 0.21 0.22 3.0e-06 1.7e-05 1.0e-05 4.8e-06
9 PL gene expression Grin3b 0.19 0.11 0.0e+00 0.21 0.22 0.22 0.22 1.9e-22 4.6e-24 5.6e-24 1.4e-23
10 Brain gene expression Grin3b 0.33 0.14 0.0e+00 0.17 0.18 0.18 0.19 7.6e-16 5.0e-17 5.7e-17 2.3e-17
11 OFC gene expression Grin3b 0.47 0.19 4.7e-07 0.13 0.18 0.22 0.22 6.8e-04 4.1e-05 6.7e-06 4.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.92.6-0.1-0.4-1.0-1.0-0.9-0.7-0.7-0.7-1.3-1.3-1.6
Area under the delay curve1.92.33.0-1.7-1.6-1.6-1.6-1.7-1.4-1.4-1.4-1.4-1.4-1.1
BMI with tail5.920.423.8-4.9-4.9-4.6-4.6-4.5-4.7-4.7-4.7-4.2-4.1-3.5
BMI without tail1.65.06.8-2.6-2.5-2.2-2.2-2.2-2.4-2.4-2.4-1.9-1.9-1.4
Body weight0.93.94.5-2.1-2.1-2.0-2.0-2.0-2.1-2.1-2.1-1.8-1.9-1.6
Weight adjusted by age0.20.30.8-0.9-0.8-0.6-0.6-0.5-0.7-0.7-0.7-0.3-0.3-0.1
Bone surface0.30.63.10.70.3-0.5-0.5-0.4-0.3-0.3-0.3-1.1-1.1-1.8
Bone volume0.40.73.30.50.1-0.7-0.7-0.6-0.3-0.3-0.3-1.2-1.2-1.8
Breakpoint value in progressive ratio session3.84.64.92.22.22.12.12.22.22.22.22.22.11.9
Number of licking bursts0.10.21.0-0.3-0.20.10.10.10.30.30.30.40.51.0
Context. condit. distance diff. score0.20.20.5-0.5-0.4-0.1-0.1-0.5-0.7-0.7-0.7-0.2-0.6-0.4
Locomotion velocity, session 10.20.20.70.80.70.30.30.40.40.40.40.0-0.0-0.4
Locomotion distance, session 10.30.31.70.80.60.30.3-0.1-0.1-0.1-0.1-0.5-0.8-1.3
Locomotion velocity, session 22.83.36.62.62.42.22.21.81.71.71.71.30.90.2
Locomotion distance, session 20.81.13.11.81.50.90.91.01.11.11.10.30.2-0.5
Locomotion velocity, session 36.97.99.62.82.93.13.12.82.72.72.72.92.62.3
Locomotion distance, session 30.00.00.1-0.00.10.30.30.20.00.00.00.30.20.3
Stereotopy head waving bouts, day 35.16.07.42.72.72.72.72.42.52.52.52.22.01.6
Stereotopy head waving duration, day 36.47.78.93.03.02.92.92.72.92.92.92.52.52.0
Locomotion velocity, session 70.60.71.70.60.81.31.30.60.50.50.50.90.60.7
Locomotion distance, session 70.10.10.4-0.6-0.5-0.0-0.0-0.3-0.3-0.3-0.30.10.10.4
Stereotopy head waving bouts, day 70.10.10.40.20.1-0.1-0.1-0.2-0.0-0.0-0.0-0.4-0.4-0.6
Stereotopy head waving duration, day 70.20.20.60.70.60.40.40.30.50.50.5-0.0-0.0-0.4
Locomotion velocity, session 80.40.51.11.00.91.01.00.40.40.40.40.2-0.2-0.7
Locomotion distance, session 80.10.20.50.70.60.60.60.30.20.20.20.2-0.1-0.4
Degree of sensitization distance0.50.50.7-0.7-0.7-0.5-0.5-0.8-0.8-0.8-0.8-0.6-0.8-0.7
Degree of sensitization stereotypy2.02.12.6-1.3-1.4-1.5-1.5-1.4-1.4-1.4-1.4-1.6-1.5-1.5
Conditioned locomotion0.70.82.0-1.4-1.2-0.8-0.8-0.9-0.8-0.8-0.8-0.5-0.40.0
Cocaine response after cond. corrected3.64.47.8-2.8-2.6-2.3-2.3-2.1-2.1-2.1-2.1-1.6-1.5-0.7
Cocaine response after cond. not corrected3.84.48.0-2.8-2.7-2.3-2.3-2.1-2.1-2.1-2.1-1.6-1.4-0.7
Cocaine response before conditioning0.50.60.90.90.91.01.00.70.70.70.70.70.60.4
Saline control response0.10.10.3-0.5-0.4-0.3-0.3-0.2-0.2-0.2-0.2-0.1-0.10.1
Bone: connectivity density0.71.12.2-0.4-0.6-1.1-1.1-1.1-0.9-0.9-0.9-1.3-1.3-1.5
Bone: cortical apparent density1.11.52.3-1.2-1.3-1.5-1.5-1.2-1.1-1.1-1.1-1.2-1.0-0.9
Bone: cortical area0.71.01.6-0.7-0.8-0.9-0.9-1.1-1.0-1.0-1.0-1.2-1.2-1.3
Bone: cortical porosity0.00.00.10.40.30.10.10.10.20.20.2-0.1-0.2-0.3
Bone: cortical porosity0.20.20.80.10.0-0.2-0.2-0.3-0.2-0.2-0.2-0.6-0.7-0.9
Bone: cortical thickness1.42.32.7-1.3-1.4-1.5-1.5-1.6-1.5-1.5-1.5-1.7-1.6-1.6
Bone: cortical thickness0.20.20.8-0.10.00.20.20.30.30.30.30.50.70.9
Bone: cortical tissue density0.81.01.8-1.0-1.1-1.3-1.3-0.9-0.9-0.9-0.9-1.0-0.8-0.8
Condit. Reinf. active minus inactive responses4.75.36.12.52.52.52.52.42.32.32.32.32.11.8
Condit. Reinf. active-inactive response ratio2.62.83.41.61.61.51.51.81.61.61.61.81.81.7
Condit. Reinf. active responses3.24.06.12.52.42.22.22.02.12.12.11.71.51.0
Condit. Reinf. inactive responses0.40.51.41.21.00.80.80.60.50.50.50.2-0.1-0.5
Incentive salience index mean2.12.64.02.01.91.91.91.71.51.51.51.41.20.7
Condit. Reinf. lever presses0.20.31.80.40.2-0.1-0.1-0.3-0.3-0.3-0.3-0.7-0.9-1.3
Condit. Reinf. active minus inactive responses2.63.34.61.41.51.61.61.81.91.91.91.92.12.1
Condit. Reinf. active-inactive response ratio0.30.41.5-0.10.0-0.1-0.10.50.70.70.70.50.91.2
Condit. Reinf. active responses2.33.13.61.51.61.71.71.81.91.91.91.81.91.8
Condit. Reinf. inactive responses1.11.52.31.11.21.51.51.11.11.11.11.31.10.9
Condit. Reinf. lever presses2.12.93.61.51.51.61.61.71.81.81.81.81.91.9
Condit. Reinf. lever reinforcers received1.82.63.51.21.31.51.51.61.71.71.71.71.81.9
Conditioned reinforcement - actives1.11.82.51.11.21.31.31.41.31.31.31.51.51.6
Conditioned reinforcement - inactives0.00.00.1-0.2-0.1-0.0-0.00.0-0.0-0.0-0.00.10.20.2
Conditioned locomotion6.58.49.73.13.12.82.82.93.13.13.12.72.72.4
Patch foraging indifference point 0 sec0.20.40.5-0.6-0.6-0.7-0.7-0.7-0.6-0.6-0.6-0.7-0.7-0.7
Patch foraging indifference point AUC0.81.11.31.01.00.90.91.11.11.11.11.01.11.0
Delay disc. indifference point, 0s delay9.810.712.8-2.8-3.0-3.3-3.3-3.3-3.2-3.2-3.2-3.6-3.6-3.5
Delay disc. indifference point, 16s delay0.20.20.3-0.5-0.4-0.5-0.5-0.5-0.4-0.4-0.4-0.4-0.3-0.4
Delay disc. indifference point, 2s delay6.67.37.9-2.6-2.7-2.7-2.7-2.8-2.7-2.7-2.7-2.8-2.8-2.5
Delay disc. indifference point, 24s delay0.60.71.2-1.1-1.0-1.0-1.0-0.9-0.8-0.8-0.8-0.7-0.6-0.4
Delay disc. indifference point, 4s delay1.11.21.5-1.1-1.1-1.0-1.0-1.2-1.1-1.1-1.1-1.1-1.1-1.0
Delay disc. indifference point, 8s delay0.91.12.1-1.4-1.3-1.0-1.0-1.3-0.9-0.9-0.9-0.9-0.8-0.4
Indifference point function ln k0.10.10.3-0.5-0.5-0.3-0.3-0.4-0.4-0.4-0.4-0.2-0.2-0.1
Indifference point function log k0.10.10.3-0.5-0.5-0.3-0.3-0.4-0.4-0.4-0.4-0.2-0.2-0.1
Patch foraging total patch changes 0 sec0.20.30.4-0.5-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.6-0.6-0.6
Patch foraging total patch changes 12 sec0.30.40.7-0.9-0.8-0.7-0.7-0.8-0.6-0.6-0.6-0.5-0.4-0.1
Patch foraging total patch changes 18 sec0.61.01.31.11.11.01.01.11.01.01.00.90.80.7
Patch foraging total patch changes 24 sec0.00.00.10.30.2-0.0-0.00.20.20.20.20.00.10.0
Patch foraging total patch changes 6 sec0.10.10.20.40.40.20.20.30.40.40.40.20.20.0
Patch foraging time to switch 0 sec1.42.85.5-1.0-1.1-1.4-1.4-1.7-1.7-1.7-1.7-1.9-2.1-2.3
Patch foraging water rate 0 sec0.20.42.0-0.3-0.10.50.50.50.40.40.40.91.01.4
Patch foraging water rate 12 sec0.40.82.2-1.5-1.4-0.9-0.9-0.7-0.8-0.8-0.8-0.4-0.10.5
Patch foraging water rate 18 sec0.91.45.6-0.20.10.70.70.80.90.90.91.51.82.4
Patch foraging water rate 24 sec0.30.52.3-1.1-0.7-0.1-0.1-0.1-0.0-0.0-0.00.60.81.5
Patch foraging water rate 6 sec0.91.34.00.20.40.80.80.91.11.11.11.31.62.0
Seeking ratio, delayed vs. immediate footshock3.34.05.22.32.22.12.12.02.12.12.11.91.71.3
Distance traveled before self-admin0.30.40.5-0.4-0.5-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.7-0.7
Distance traveled after self-admin0.00.00.00.10.0-0.1-0.1-0.0-0.0-0.0-0.0-0.1-0.1-0.1
Extensor digitorum longus weight3.313.219.1-4.4-4.2-3.4-3.4-3.9-3.9-3.9-3.9-3.1-3.1-2.3
Bone: elastic displacement0.10.10.20.30.2-0.1-0.10.40.40.40.40.20.40.2
Bone: elastic work0.50.60.9-0.7-0.8-1.0-1.0-0.7-0.7-0.7-0.7-0.8-0.7-0.7
Bone: endosteal estimation0.10.30.5-0.5-0.5-0.3-0.3-0.5-0.7-0.7-0.7-0.5-0.7-0.7
Bone: endosteal perimeter0.20.40.80.90.80.80.80.60.60.60.60.50.30.2
Epididymis fat weight0.10.21.1-0.00.10.30.30.40.30.30.30.60.71.0
Delta time in closed arm before/after self-admin0.30.31.1-1.0-0.8-0.3-0.3-0.3-0.3-0.3-0.30.20.40.9
Delta time in open arm before/after self-admin0.60.60.8-0.7-0.8-0.9-0.9-0.7-0.7-0.7-0.7-0.7-0.7-0.6
Diff in mean of infusions in LGA sessions1.72.02.51.61.61.41.41.51.51.51.51.41.31.1
Delay discount exponential model param1.61.82.51.61.51.41.41.61.31.31.31.31.20.9
Extinction: sum of active levers before priming1.01.11.30.91.01.01.01.01.01.01.01.11.11.1
Active lever presses in extinction session 61.41.42.31.51.41.01.01.31.31.31.31.01.00.8
Bone: final force1.62.53.3-1.5-1.5-1.4-1.4-1.7-1.6-1.6-1.6-1.7-1.8-1.7
Bone: final moment1.32.12.8-1.3-1.4-1.3-1.3-1.6-1.4-1.4-1.4-1.5-1.7-1.5
Food consumed during 24 hour testing period0.40.60.9-1.0-0.9-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.6-0.4
Glucose2.64.15.2-2.3-2.3-2.2-2.2-2.0-2.0-2.0-2.0-1.9-1.8-1.4
Heart weight1.01.52.90.80.91.01.01.31.21.21.21.41.51.7
Delay discount hyperbolic model param3.03.44.12.02.01.91.92.01.81.81.81.81.71.4
Intermittent access intake day 1-15 change3.57.18.42.52.62.92.92.72.62.62.62.82.72.6
Intermittent access intake escalation3.16.37.52.42.42.72.72.52.42.42.42.62.62.4
Intermittent access intake escalation 24.75.46.12.32.32.52.52.32.22.22.22.42.42.2
Intermitt. access day 1 inactive lever presses0.10.51.30.10.20.80.80.60.40.40.40.90.91.1
Intermitt. access day 15 inactive lever presses0.20.40.70.80.80.70.70.70.70.70.70.60.50.4
Intermitt. access escalation Index1.21.72.9-0.8-1.0-1.3-1.3-1.2-1.4-1.4-1.4-1.3-1.5-1.7
Intermittent access day 1 total infusions0.20.40.90.30.40.40.40.60.60.60.60.70.81.0
Intermittent access day 15 total infusions2.84.14.51.92.02.12.12.02.02.02.02.12.12.0
Intermittent access terminal intake (last 3 days)2.02.63.21.61.61.81.81.61.61.61.61.61.61.5
Intermittent access total infusions1.11.31.51.11.11.21.21.21.11.11.11.21.21.2
Intermittent access day 1 locomotion2.12.73.51.31.41.61.61.71.71.71.71.81.81.9
Intermittent access day 15 total locomotion3.46.16.82.32.42.62.62.52.42.42.42.62.62.3
Intermittent access total locomotion2.73.33.81.71.71.91.91.91.81.81.81.91.91.7
Intermittent access standard deviation3.57.37.92.82.82.82.82.82.72.72.72.72.62.3
Left kidney weight0.00.20.5-0.2-0.00.70.70.20.00.00.00.60.40.6
Right kidney weight0.62.94.01.31.41.91.91.71.61.61.62.01.82.0
Cocaine induced anxiety0.60.82.01.41.30.90.90.90.90.90.90.50.4-0.1
Post-drug Anxiety0.80.82.11.41.30.90.90.90.90.90.90.50.3-0.1
Baseline Anxiety0.10.10.20.20.30.30.30.30.30.30.30.40.40.4
Tail length3.513.515.13.73.73.93.93.73.73.73.73.73.53.3
Length with tail2.08.710.33.03.03.23.22.92.92.92.93.02.82.6
Length without tail0.00.00.0-0.1-0.10.00.0-0.1-0.1-0.1-0.1-0.0-0.00.0
Times rat made contact with spout0.10.10.4-0.6-0.5-0.2-0.2-0.3-0.2-0.2-0.20.00.10.3
Lifetime Intake0.60.80.90.80.80.90.90.90.90.90.91.00.91.0
Liver weight, left0.81.21.6-1.3-1.3-1.2-1.2-1.0-1.1-1.1-1.1-1.0-1.0-0.8
Liver weight, right0.40.71.2-1.1-1.0-0.7-0.7-0.8-1.0-1.0-1.0-0.5-0.6-0.4
Locomotor activity1.93.04.92.22.11.91.91.51.91.91.91.31.30.8
Locomotor testing distance1.01.93.21.81.71.41.41.31.51.51.51.01.00.6
Locomotor testing rearing0.10.10.5-0.00.10.20.20.20.40.40.40.40.50.7
Locomotion in novel chamber0.91.21.41.01.01.01.01.11.21.21.21.11.11.0
Locomotion in novel chamber post-restriction1.52.43.11.41.41.81.81.61.51.51.51.61.51.5
Fecal boli incidents, locomotor time 11.52.22.9-1.4-1.4-1.3-1.3-1.5-1.7-1.7-1.7-1.3-1.5-1.5
Change in fecal boli incidents, locomotor task0.10.10.30.30.40.50.50.30.20.20.20.20.20.0
Time >=10cm from walls, locomotor time 11.31.42.5-0.7-0.9-1.2-1.2-1.1-1.1-1.1-1.1-1.4-1.4-1.6
Bouts of movement, locomotor time 10.60.71.50.60.71.21.20.60.60.60.60.90.70.7
Total resting periods, locomotor time 10.60.71.60.70.81.21.20.70.60.60.60.90.70.6
Rest time, locomotor task time 10.30.41.40.70.71.21.20.50.30.30.30.60.30.1
Distance moved, locomotor task time 11.21.82.6-1.0-1.1-1.5-1.5-1.2-1.2-1.2-1.2-1.5-1.5-1.6
Vertical activity count, locomotor time 10.20.51.3-0.8-0.8-1.1-1.1-0.5-0.4-0.4-0.4-0.5-0.2-0.0
Time >=10cm from walls, locomotor time 21.01.52.2-1.5-1.5-1.2-1.2-1.4-1.2-1.2-1.2-1.1-1.1-0.6
Bouts of movement, locomotor time 20.20.30.70.80.70.40.40.50.60.60.60.20.1-0.1
Total resting periods, locomotor time 20.10.20.70.80.70.30.30.40.60.60.60.10.0-0.1
Rest time, locomotor task time 20.40.61.01.00.90.90.90.70.80.80.80.60.50.3
Distance moved, locomotor task time 20.50.50.9-0.9-0.9-0.8-0.8-0.8-0.7-0.7-0.7-0.7-0.6-0.4
Vertical activity count, locomotor time 20.30.40.9-1.0-0.9-0.7-0.7-0.6-0.6-0.6-0.6-0.3-0.30.1
Light reinforcement 13.48.412.63.53.42.92.93.03.03.03.02.52.51.8
Light reinforcement 21.32.03.11.81.71.31.31.41.51.51.51.21.30.8
Bone: marrow area0.10.30.5-0.5-0.5-0.3-0.3-0.5-0.7-0.7-0.7-0.4-0.7-0.6
Bone: maximum diameter0.51.01.91.41.31.11.11.01.01.01.00.70.60.2
Bone: maximum force1.32.42.9-1.5-1.6-1.4-1.4-1.7-1.6-1.6-1.6-1.5-1.7-1.5
Bone: maximum moment1.12.02.4-1.4-1.4-1.3-1.3-1.5-1.4-1.4-1.4-1.4-1.6-1.4
Mean time between licks in bursts2.66.36.82.52.62.62.62.62.62.62.62.52.42.1
Mean num. licks in bursts0.10.10.3-0.1-0.2-0.3-0.3-0.2-0.4-0.4-0.4-0.3-0.4-0.6
Cd content in liver0.10.10.20.40.3-0.0-0.00.30.40.40.40.10.30.2
Co content in liver1.71.92.31.31.31.31.31.41.51.51.51.31.51.4
Cu content in liver0.10.10.30.60.50.40.40.10.20.20.2-0.1-0.1-0.4
Fe content in liver0.40.41.10.50.61.01.00.50.50.50.50.70.50.6
K content in liver0.10.10.40.20.20.20.2-0.2-0.1-0.1-0.1-0.3-0.4-0.6
Mg content in liver0.20.20.30.60.50.40.40.40.50.50.50.20.20.1
Mn content in liver0.80.82.11.51.31.11.10.80.80.80.80.50.2-0.3
Na content in liver1.31.42.6-0.8-0.8-0.8-0.8-1.3-1.2-1.2-1.2-1.4-1.5-1.6
Rb content in liver0.10.20.70.20.1-0.2-0.2-0.2-0.2-0.2-0.2-0.5-0.6-0.9
Se content in liver0.40.40.90.60.71.01.00.50.50.50.50.60.50.4
Sr content in liver0.00.00.1-0.1-0.10.00.00.00.00.00.00.10.20.3
Zn content in liver4.95.47.91.92.01.91.92.42.42.42.42.52.72.8
Bone: minimum diameter0.00.10.3-0.0-0.00.20.2-0.2-0.3-0.3-0.3-0.2-0.4-0.5
Time in familiar zone, hab. session 12.82.73.21.51.51.51.51.61.71.71.71.71.81.8
Time in novel zone, hab. session 11.71.72.6-1.0-1.1-1.2-1.2-1.2-1.3-1.3-1.3-1.4-1.5-1.6
Total zone transitions, hab. session 10.50.71.71.31.20.90.90.70.90.90.90.30.2-0.3
Total locomotion distance, hab. session 10.60.92.31.51.41.21.20.70.90.90.90.20.1-0.6
Locomotion velocity, hab. session 11.11.53.21.81.71.51.51.01.21.21.20.60.4-0.2
Time in familiar zone, hab. session 27.47.88.92.72.72.62.63.02.82.82.83.02.92.8
Time in novel zone, hab. session 25.85.86.6-2.3-2.4-2.3-2.3-2.5-2.4-2.4-2.4-2.6-2.5-2.4
Total zone transitions, hab. session 20.81.14.1-0.1-0.3-0.7-0.7-0.9-0.7-0.7-0.7-1.4-1.5-2.0
Total locomotion distance, hab. session 20.70.92.31.51.30.90.90.81.01.01.00.40.3-0.3
Locomotion velocity, hab. session 20.60.82.31.51.30.80.80.70.90.90.90.10.1-0.6
Novel to familiar place preference ratio5.76.27.7-2.1-2.3-2.4-2.4-2.4-2.5-2.5-2.5-2.6-2.7-2.8
Novelty place preference3.74.05.3-1.6-1.7-1.9-1.9-1.9-2.0-2.0-2.0-2.1-2.2-2.3
Time in novel zone, NPP test4.04.35.4-1.7-1.8-1.9-1.9-2.0-2.1-2.1-2.1-2.2-2.3-2.3
Total zone transitions, NPP test0.20.31.50.20.0-0.4-0.4-0.4-0.2-0.2-0.2-0.9-0.8-1.2
Total locomotion distance, NPP test0.20.31.50.20.1-0.1-0.1-0.4-0.2-0.2-0.2-0.8-0.8-1.2
Locomotion velocity, NPP test0.10.21.00.50.30.00.0-0.10.10.10.1-0.5-0.6-1.0
Intraocular pressure0.20.31.4-0.2-0.1-0.1-0.10.40.30.30.30.60.81.2
Delta distance traveled before/after self-admin0.50.50.60.70.70.80.80.70.70.70.70.70.70.7
Delta ambulatory time before/after self-admin0.40.50.60.70.70.80.80.60.60.60.60.60.60.5
Parametrial fat weight0.00.00.20.1-0.0-0.2-0.2-0.1-0.2-0.2-0.2-0.3-0.4-0.4
Pavlov. Cond. lever latency0.10.20.8-0.3-0.2-0.3-0.30.30.10.10.10.40.50.9
Pavlov. Cond. magazine entry latency3.64.66.32.32.32.52.52.12.12.12.12.11.81.6
Pavlov. Cond. change in total contacts0.20.20.60.40.40.80.80.10.20.20.20.30.1-0.0
Pavlov. Cond. index score0.50.71.61.11.01.31.30.60.70.70.70.60.40.1
Pavlov. Cond. latency score0.50.61.41.11.01.21.20.50.60.60.60.40.2-0.1
Pavlov. Cond. lever contacts0.10.10.70.30.20.30.3-0.3-0.1-0.1-0.1-0.4-0.5-0.8
Pavlov. Cond. magazine entry number1.21.52.4-1.3-1.3-1.5-1.5-1.1-1.1-1.1-1.1-1.2-1.0-0.9
Pavlov. Cond. intertrial magazine entries0.30.41.00.20.30.30.30.50.60.60.60.70.91.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.81.21.11.41.40.70.80.80.80.80.50.2
Pavlov. Cond. response bias1.21.42.51.31.31.61.61.11.11.11.11.21.00.8
Pavlov. Cond. lever latency0.70.91.2-0.8-0.8-0.9-0.9-1.0-1.0-1.0-1.0-0.9-1.0-1.1
Pavlov. Cond. magazine entry latency0.40.50.70.70.70.80.80.70.60.60.60.70.70.7
Pavlov. Cond. change in total contacts0.50.81.40.60.70.70.70.91.01.01.00.91.11.2
Pavlov. Cond. index score0.60.91.20.70.80.90.90.91.01.01.00.91.01.1
Pavlov. Cond. latency score0.60.80.90.80.80.80.80.90.90.90.90.90.91.0
Pavlov. Cond. lever contacts0.60.81.40.70.70.80.80.90.90.90.91.01.11.2
Pavlov. Cond. magazine entry number0.70.91.2-0.9-0.9-1.1-1.1-0.9-0.9-0.9-0.9-0.9-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.10.20.5-0.7-0.7-0.4-0.4-0.4-0.5-0.5-0.5-0.3-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.60.91.00.80.80.90.90.91.01.01.00.91.01.0
Pavlov. Cond. response bias1.72.33.11.21.31.41.41.51.61.61.61.61.71.8
Time in closed arm before self-admin0.60.81.8-0.5-0.6-0.8-0.8-0.9-0.9-0.9-0.9-1.1-1.2-1.3
Time in closed arm after self-admin0.30.30.60.30.40.60.60.50.50.50.50.70.70.8
Time in open arm before self-admin0.10.10.10.30.30.40.40.20.20.20.20.20.20.1
Time in open arm after self-admin1.01.11.3-1.1-1.1-1.1-1.1-1.0-1.0-1.0-1.0-1.0-0.9-0.8
Bone: periosteal estimation0.30.71.4-0.5-0.6-0.6-0.6-0.8-0.9-0.9-0.9-0.9-1.1-1.2
Bone: periosteal perimeter0.00.10.20.40.30.30.30.10.20.20.2-0.1-0.2-0.3
Bone: post-yield work0.40.61.0-1.0-0.9-0.4-0.4-0.9-0.9-0.9-0.9-0.6-0.7-0.5
Progressive ratio test 1 active lever presses0.30.41.00.20.30.60.60.60.50.50.50.80.81.0
Progressive ratio test 1 breakpoint0.30.40.90.20.30.60.60.60.50.50.50.80.81.0
Progressive ratio test 1 inactive lever presses0.40.60.80.70.70.80.80.80.60.60.60.90.80.7
Progressive ratio test 2 active lever presses0.50.61.60.30.40.70.70.70.70.70.71.01.11.3
Progressive ratio test 2 breakpoint0.60.71.70.40.50.70.70.80.70.70.71.11.11.3
Progressive ratio test 2 inactive lever presses0.10.10.20.50.40.40.40.40.40.40.40.40.40.3
Incentive Sensitization - Responses0.10.10.4-0.3-0.20.10.10.10.00.00.00.30.40.6
Incentive Sensitization - Breakpoint0.10.10.4-0.1-0.00.20.20.20.10.10.10.40.50.7
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.2-0.3-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.2
Progressive ratio0.10.10.3-0.5-0.4-0.3-0.3-0.4-0.3-0.3-0.3-0.2-0.2-0.1
Food seeking constrained by brief footshock0.30.40.90.90.81.01.00.60.50.50.50.40.30.1
Seeking ratio, punishment vs. effort0.20.30.70.80.70.60.60.60.40.40.40.30.2-0.0
Retroperitoneal fat weight0.20.81.6-1.3-1.2-0.8-0.8-0.9-1.0-1.0-1.0-0.6-0.7-0.2
Reaction time number correct0.10.20.9-0.9-0.8-0.3-0.3-0.3-0.4-0.4-0.40.10.20.6
Reaction time mean minus median0.30.81.10.80.80.90.91.00.90.90.91.01.01.0
Reaction time mean minus median AUC0.00.10.30.1-0.0-0.0-0.0-0.0-0.2-0.2-0.2-0.3-0.4-0.5
Reaction time num false alarms0.10.10.5-0.7-0.5-0.1-0.1-0.3-0.2-0.2-0.20.10.20.6
Reaction time num false alarms AUC0.10.10.6-0.8-0.5-0.1-0.1-0.3-0.1-0.1-0.10.20.30.7
Reaction time trials correct on left0.10.20.9-0.9-0.8-0.3-0.3-0.3-0.4-0.4-0.40.10.20.6
Reaction time trials on left0.10.20.9-1.0-0.8-0.3-0.3-0.3-0.4-0.4-0.40.10.20.5
Reaction time mean0.10.10.2-0.2-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.4-0.4
Reaction time mean AUC0.10.20.3-0.3-0.4-0.5-0.5-0.4-0.4-0.4-0.4-0.5-0.4-0.5
Median of all reaction times0.50.70.9-0.7-0.7-0.9-0.9-0.8-0.8-0.8-0.8-0.9-0.9-0.9
Reaction time omissions0.00.10.20.50.3-0.0-0.00.30.10.10.1-0.0-0.1-0.4
Reaction time false alarm rate0.00.10.2-0.4-0.3-0.2-0.2-0.4-0.2-0.2-0.2-0.2-0.1-0.0
Reaction time premature initiation rate1.11.52.11.01.11.01.01.31.31.31.31.31.41.4
Reaction time premature initiations0.91.63.40.70.81.01.01.31.21.21.21.51.61.9
Std. dev. reaction times0.10.10.20.30.30.30.30.50.40.40.40.40.30.3
Reaction time trials completed0.10.20.9-1.0-0.8-0.3-0.3-0.3-0.4-0.4-0.40.10.20.5
Reaction time trials AUC0.10.30.9-1.0-0.8-0.3-0.3-0.3-0.3-0.3-0.30.20.30.7
Run reversals in cocaine runway, females0.50.50.80.90.90.80.80.70.70.70.70.60.40.2
Run reversals in cocaine runway, males1.71.72.61.61.51.41.41.41.31.31.31.11.00.8
Latency to leave start box in cocaine runway0.10.10.30.60.5-0.2-0.20.20.30.30.3-0.1-0.2-0.5
Latency to leave start box in cocaine runway, F0.80.92.6-0.2-0.4-1.1-1.1-0.6-0.7-0.7-0.7-1.2-1.3-1.6
Latency to leave start box in cocaine runway, M2.12.02.41.21.41.31.31.31.51.51.51.51.51.5
Std. dev. time between licks in bursts0.50.71.00.90.91.01.00.80.90.90.90.70.60.5
Total sessions with >9 infusions0.40.50.70.50.50.80.80.70.60.60.60.80.80.8
Short access day 1 total inactive lever presses0.40.50.60.70.70.70.70.80.60.60.60.80.70.5
Short access day 10 total inactive lever presses0.00.00.2-0.2-0.10.20.20.00.10.10.10.10.20.5
Short access day 1 total infusions0.40.50.60.80.70.80.80.80.60.60.60.70.60.5
Short access day 10 total infusions0.20.30.60.30.30.60.60.50.40.40.40.70.70.8
Short access total infusions0.40.50.60.60.60.70.70.70.70.70.70.80.70.8
Short access day 1 locomotion1.41.82.11.31.41.31.31.41.31.31.31.41.31.2
Short access day 10 total locomotion4.99.110.32.62.83.23.23.03.03.03.03.23.13.1
Short access total locomotion2.63.13.51.61.71.81.81.81.81.81.81.91.81.8
One hour access (0.3 mA shock)0.00.00.1-0.1-0.00.10.10.10.20.20.20.20.20.3
Compulsive drug intake1.72.03.0-1.1-1.2-1.4-1.4-1.5-1.2-1.2-1.2-1.7-1.7-1.7
One hour access (shock baseline)0.81.31.90.80.91.11.11.11.11.11.11.31.31.4
Social response proportion0.60.71.21.11.00.80.80.80.90.90.90.60.50.2
Social responses6.07.79.93.13.12.92.92.82.92.92.92.52.31.9
Social time0.40.60.9-0.7-0.8-0.9-0.9-0.8-0.6-0.6-0.6-0.9-0.8-0.6
Soleus weight8.023.627.1-5.2-5.2-4.9-4.9-5.0-5.0-5.0-5.0-4.6-4.5-3.8
Bone: stiffness2.64.25.1-2.1-2.0-1.7-1.7-2.3-2.2-2.2-2.2-2.1-2.2-1.9
Tibialis anterior weight0.93.03.8-2.0-1.9-1.4-1.4-1.9-1.9-1.9-1.9-1.6-1.7-1.4
Time to tail flick, vehicle, before self-admin0.00.00.10.40.30.00.00.20.20.20.20.10.0-0.1
Time to tail flick, vehicle, after self-admin0.81.12.40.50.71.01.00.90.90.90.91.21.31.6
Time to tail flick, test, before self-admin0.10.10.30.60.50.30.30.40.40.40.40.10.1-0.1
Time to tail flick, test, after self-admin0.20.20.40.40.40.60.60.40.40.40.40.40.40.3
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.4-0.30.20.2-0.0-0.0-0.0-0.00.40.50.8
Delta time to tail flick, test, before/after SA0.20.20.8-0.00.10.50.50.30.30.30.30.60.60.9
Tibia length0.92.52.91.51.51.61.61.51.71.71.71.51.61.5
Ambulatory time before self-admin0.30.40.5-0.5-0.5-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.6-0.7
Ambulatory time after self-admin0.00.00.10.0-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.2-0.2-0.3
Bone: tissue strength2.32.32.6-1.5-1.5-1.6-1.6-1.6-1.5-1.5-1.5-1.6-1.5-1.4
Total heroin consumption1.31.52.21.51.41.21.21.31.31.31.31.11.00.8
Bone: trabecular number0.10.20.80.90.80.40.40.30.40.40.40.10.1-0.3
Bone: trabecular spacing0.20.31.1-0.9-0.7-0.1-0.1-0.1-0.1-0.1-0.10.40.51.0
Bone: trabecular thickness1.11.44.50.0-0.4-1.1-1.1-1.0-0.7-0.7-0.7-1.6-1.6-2.1
Bone: trabecular tissue density1.01.42.0-1.4-1.4-1.1-1.1-1.3-1.2-1.2-1.2-1.1-1.1-0.8
Water consumed over 24 hours0.81.11.4-1.0-1.0-0.9-0.9-1.2-1.1-1.1-1.1-1.1-1.1-1.1
Number of responses in last shaping day2.02.22.81.41.41.61.61.61.41.41.41.71.61.5