Hub : Genes

Grin3a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Grin3a 0.13 0.08 3.5e-03 0.05 0.04 0.09 0.02 2.2e-02 3.1e-02 2.2e-03 9.4e-02
2 Brain gene expression Grin3a 0.06 0.03 3.0e-06 0.04 0.05 0.03 0.04 1.5e-04 2.1e-05 3.6e-04 5.7e-05
3 PL gene expression Grin3a 0.14 0.08 9.2e-08 0.02 0.05 0.06 0.03 1.4e-03 7.0e-06 5.1e-07 2.9e-04
4 NAcc mRNA stability Grin3a 0.03 0.02 3.1e-05 0.02 0.03 0.02 0.02 8.7e-04 9.6e-05 4.5e-04 3.2e-04
5 NAcc gene expression Grin3a 0.04 0.02 1.5e-08 0.06 0.06 0.06 0.06 5.0e-10 3.7e-09 2.2e-09 2.3e-09
6 pVTA gene expression Grin3a 0.12 0.06 9.5e-10 0.14 0.13 0.15 0.14 5.7e-11 2.7e-10 7.9e-12 9.4e-12
7 Brain mRNA stability Grin3a 0.02 0.02 9.3e-03 0.01 0.01 0 0 4.9e-02 8.5e-02 2.3e-01 9.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.71.32.3-0.31.3-0.8-1.40.91.31.5
Area under the delay curve2.64.07.2-0.02.7-2.0-2.42.12.01.4
BMI with tail3.010.617.90.5-2.92.73.6-3.6-3.9-4.2
BMI without tail0.73.66.9-1.4-1.51.32.1-1.8-2.1-2.6
Body weight2.611.516.2-0.5-3.84.03.9-3.8-3.4-3.0
Weight adjusted by age0.10.20.70.60.10.8-0.10.10.40.5
Bone surface0.40.72.70.20.40.4-0.80.31.11.6
Bone volume0.30.51.20.30.7-0.2-0.90.40.91.1
Breakpoint value in progressive ratio session1.32.43.81.2-1.21.11.7-1.7-1.8-1.9
Number of licking bursts0.10.20.8-0.90.4-0.4-0.3-0.4-0.30.2
Context. condit. distance diff. score0.50.60.90.90.6-0.7-0.71.00.90.7
Locomotion velocity, session 10.00.00.1-0.30.1-0.0-0.10.1-0.10.0
Locomotion distance, session 10.30.41.3-0.01.1-1.1-0.60.4-0.10.0
Locomotion velocity, session 20.20.21.11.10.5-0.0-0.40.00.20.4
Locomotion distance, session 21.62.25.2-0.32.3-1.8-1.81.10.91.1
Locomotion velocity, session 30.30.42.61.6-0.00.10.1-0.1-0.0-0.3
Locomotion distance, session 30.70.82.00.81.1-1.4-0.80.90.2-0.6
Stereotopy head waving bouts, day 31.31.62.3-1.1-1.51.41.3-1.5-1.2-0.4
Stereotopy head waving duration, day 31.41.72.8-1.2-1.71.21.4-1.6-1.3-0.5
Locomotion velocity, session 71.71.92.9-0.11.7-1.3-1.61.21.41.5
Locomotion distance, session 71.11.31.90.21.4-1.3-1.31.21.01.2
Stereotopy head waving bouts, day 70.20.30.6-0.6-0.30.40.4-0.8-0.5-0.6
Stereotopy head waving duration, day 70.81.01.7-0.3-0.90.91.1-1.3-1.0-1.2
Locomotion velocity, session 80.00.10.10.2-0.10.30.2-0.3-0.2-0.3
Locomotion distance, session 81.92.74.60.82.1-1.9-1.91.61.51.5
Degree of sensitization distance0.50.62.0-0.7-0.30.80.1-0.70.11.4
Degree of sensitization stereotypy0.10.10.2-0.40.5-0.2-0.3-0.10.2-0.1
Conditioned locomotion0.30.31.1-1.10.40.2-0.3-0.50.20.7
Cocaine response after cond. corrected0.10.10.4-0.60.2-0.2-0.1-0.3-0.3-0.3
Cocaine response after cond. not corrected0.10.20.8-0.90.30.0-0.1-0.5-0.3-0.3
Cocaine response before conditioning0.00.00.10.20.20.3-0.0-0.10.1-0.0
Saline control response0.50.72.10.7-0.91.40.5-0.80.20.8
Bone: connectivity density1.32.15.0-0.01.3-0.7-1.71.21.82.2
Bone: cortical apparent density0.10.10.3-0.40.5-0.2-0.40.10.40.2
Bone: cortical area0.81.33.3-0.6-1.61.80.9-1.2-0.40.7
Bone: cortical porosity1.92.14.8-0.3-1.92.21.6-1.6-1.0-0.5
Bone: cortical porosity1.71.94.4-0.4-1.82.11.4-1.5-0.9-0.2
Bone: cortical thickness0.40.71.3-0.4-1.01.10.5-1.1-0.20.9
Bone: cortical thickness0.81.02.5-0.7-1.01.60.7-1.5-0.50.6
Bone: cortical tissue density0.10.10.3-0.40.6-0.3-0.50.10.30.1
Condit. Reinf. active minus inactive responses0.10.20.4-0.50.4-0.1-0.2-0.4-0.30.6
Condit. Reinf. active-inactive response ratio0.50.51.5-0.8-0.50.40.6-1.0-1.2-0.2
Condit. Reinf. active responses0.30.41.40.20.8-0.1-0.60.00.41.2
Condit. Reinf. inactive responses1.11.42.21.51.3-0.3-1.20.71.41.4
Incentive salience index mean0.10.20.5-0.70.3-0.0-0.0-0.5-0.40.4
Condit. Reinf. lever presses0.20.31.9-1.40.4-0.2-0.1-0.3-0.20.2
Condit. Reinf. active minus inactive responses1.21.82.80.81.3-0.9-1.41.51.71.6
Condit. Reinf. active-inactive response ratio0.40.61.5-0.60.7-0.3-0.80.70.81.2
Condit. Reinf. active responses1.62.33.00.81.7-1.5-1.71.71.71.4
Condit. Reinf. inactive responses0.10.20.50.20.6-0.7-0.50.30.40.1
Condit. Reinf. lever presses2.23.25.20.71.9-1.5-2.01.62.32.0
Condit. Reinf. lever reinforcers received1.82.53.20.71.8-1.6-1.71.81.81.4
Conditioned reinforcement - actives1.76.817.04.12.4-2.0-2.32.72.61.3
Conditioned reinforcement - inactives2.46.510.11.42.7-2.3-2.73.22.92.1
Conditioned locomotion3.34.918.44.31.6-1.5-1.71.82.01.0
Patch foraging indifference point 0 sec0.30.91.80.31.3-1.2-1.10.90.80.4
Patch foraging indifference point AUC0.51.27.42.7-0.20.70.3-0.5-0.1-0.1
Delay disc. indifference point, 0s delay3.43.86.20.32.2-1.5-2.32.52.51.4
Delay disc. indifference point, 16s delay4.26.09.0-0.23.0-2.9-2.82.62.61.8
Delay disc. indifference point, 2s delay0.70.71.4-0.41.2-0.8-0.91.00.90.5
Delay disc. indifference point, 24s delay0.10.20.60.40.8-0.7-0.50.30.3-0.0
Delay disc. indifference point, 4s delay4.24.48.2-0.12.9-2.2-2.52.22.11.6
Delay disc. indifference point, 8s delay0.71.22.11.51.4-0.6-1.21.01.10.5
Indifference point function ln k0.41.35.5-2.4-0.5-0.10.7-0.6-1.0-1.3
Indifference point function log k0.41.35.5-2.4-0.5-0.10.7-0.6-1.0-1.3
Patch foraging total patch changes 0 sec0.10.20.4-0.10.7-0.7-0.40.30.2-0.1
Patch foraging total patch changes 12 sec0.20.31.51.20.5-0.1-0.30.10.30.4
Patch foraging total patch changes 18 sec0.10.20.70.70.8-0.2-0.4-0.20.10.1
Patch foraging total patch changes 24 sec0.10.42.61.6-0.20.40.3-0.2-0.3-0.2
Patch foraging total patch changes 6 sec0.00.10.20.50.30.10.0-0.20.1-0.4
Patch foraging time to switch 0 sec0.51.82.6-0.31.6-1.6-1.61.61.20.9
Patch foraging water rate 0 sec0.31.32.3-0.5-1.20.81.4-1.0-1.1-1.5
Patch foraging water rate 12 sec0.41.74.7-2.2-0.70.71.2-1.2-1.1-1.4
Patch foraging water rate 18 sec1.53.48.8-3.0-1.61.41.7-1.8-1.5-1.2
Patch foraging water rate 24 sec1.21.75.8-2.4-0.90.71.1-1.0-0.8-1.4
Patch foraging water rate 6 sec1.21.72.8-1.5-1.71.31.5-1.0-0.8-1.2
Seeking ratio, delayed vs. immediate footshock0.50.81.5-0.5-1.20.60.9-1.0-1.1-0.6
Distance traveled before self-admin0.71.69.7-3.10.40.5-0.5-0.20.40.9
Distance traveled after self-admin0.20.42.6-1.60.00.2-0.0-0.3-0.20.4
Extensor digitorum longus weight0.10.31.11.00.5-0.5-0.10.00.1-0.7
Bone: elastic displacement0.60.81.70.10.8-0.4-1.00.81.21.3
Bone: elastic work0.30.31.3-0.2-0.10.8-0.1-0.40.51.1
Bone: endosteal estimation0.51.14.1-2.0-0.91.20.7-0.9-0.50.1
Bone: endosteal perimeter1.02.54.7-0.3-2.22.11.8-1.3-1.5-1.1
Epididymis fat weight1.57.710.70.6-3.32.83.2-3.2-3.2-2.2
Delta time in closed arm before/after self-admin7.06.642.96.6-0.51.20.7-0.6-0.3-0.9
Delta time in open arm before/after self-admin2.12.510.6-3.31.3-1.6-1.20.80.80.6
Diff in mean of infusions in LGA sessions0.30.52.41.6-0.00.00.3-0.1-0.4-0.8
Delay discount exponential model param2.53.46.7-0.1-2.62.02.2-1.9-1.8-1.2
Extinction: sum of active levers before priming0.40.62.11.50.9-0.2-0.70.10.50.5
Active lever presses in extinction session 60.70.74.72.20.20.4-0.1-0.10.30.3
Bone: final force0.20.30.7-0.7-0.80.40.6-0.6-0.5-0.1
Bone: final moment0.30.51.0-0.7-1.00.60.8-0.8-0.7-0.3
Food consumed during 24 hour testing period0.30.50.90.20.8-0.5-0.80.80.90.9
Glucose0.20.32.01.4-0.40.00.30.2-0.0-0.1
Heart weight0.00.00.10.3-0.2-0.00.3-0.2-0.1-0.2
Delay discount hyperbolic model param2.63.36.70.1-2.61.92.2-1.9-1.8-1.2
Intermittent access intake day 1-15 change0.63.310.6-3.21.1-0.2-1.31.72.01.7
Intermittent access intake escalation0.52.79.2-3.01.0-0.3-1.11.51.81.3
Intermittent access intake escalation 21.93.215.0-3.90.50.3-0.91.01.81.5
Intermitt. access day 1 inactive lever presses0.00.30.8-0.3-0.90.30.4-0.4-0.80.5
Intermitt. access day 15 inactive lever presses0.00.31.6-1.3-0.1-0.4-0.00.1-0.00.2
Intermitt. access escalation Index0.31.02.7-0.0-1.31.71.0-0.8-0.80.5
Intermittent access day 1 total infusions2.67.921.04.62.4-3.7-2.32.61.70.5
Intermittent access day 15 total infusions2.25.48.01.72.4-2.6-2.42.82.51.5
Intermittent access terminal intake (last 3 days)2.85.06.71.52.3-2.5-2.42.62.51.6
Intermittent access total infusions5.56.510.12.42.6-3.2-2.62.92.31.4
Intermittent access day 1 locomotion2.54.620.14.51.4-2.6-1.31.30.50.1
Intermittent access day 15 total locomotion1.24.69.93.12.2-1.9-2.02.22.01.1
Intermittent access total locomotion5.76.911.03.12.7-3.3-2.62.72.11.2
Intermittent access standard deviation0.94.78.11.01.7-1.8-2.22.62.82.3
Left kidney weight0.97.19.1-2.0-2.82.33.0-2.8-2.8-2.8
Right kidney weight1.712.216.2-2.4-3.93.14.0-3.3-3.7-3.6
Cocaine induced anxiety0.00.10.2-0.30.10.2-0.0-0.10.40.2
Post-drug Anxiety1.92.26.3-2.5-1.11.61.2-1.7-0.9-0.4
Baseline Anxiety3.05.17.3-2.0-2.22.02.4-2.5-2.7-2.0
Tail length0.21.15.4-2.3-0.80.90.40.00.20.6
Length with tail0.62.85.9-2.1-2.12.41.5-1.4-0.70.5
Length without tail0.73.67.70.4-2.52.82.0-2.1-1.6-0.6
Times rat made contact with spout0.20.20.4-0.7-0.50.60.5-0.6-0.40.0
Lifetime Intake5.87.110.22.72.7-3.2-2.72.92.51.8
Liver weight, left0.20.41.2-0.6-0.30.30.6-0.3-0.7-1.1
Liver weight, right0.50.92.0-1.3-0.60.30.9-0.6-1.1-1.4
Locomotor activity1.52.34.6-1.2-1.92.11.7-1.1-1.0-1.2
Locomotor testing distance0.30.72.2-0.9-0.91.50.8-0.4-0.2-0.5
Locomotor testing rearing0.10.31.5-0.5-0.51.20.4-0.50.10.2
Locomotion in novel chamber1.01.32.20.1-1.31.51.2-1.2-1.1-1.0
Locomotion in novel chamber post-restriction0.20.50.90.8-0.4-0.60.4-0.6-0.8-1.0
Fecal boli incidents, locomotor time 10.10.30.60.80.4-0.6-0.00.2-0.4-0.8
Change in fecal boli incidents, locomotor task0.20.20.80.5-0.4-0.90.10.0-0.2-0.6
Time >=10cm from walls, locomotor time 10.30.42.11.50.4-0.0-0.30.40.4-0.3
Bouts of movement, locomotor time 10.20.20.60.80.30.4-0.40.50.30.4
Total resting periods, locomotor time 10.10.10.30.50.20.4-0.10.2-0.00.1
Rest time, locomotor task time 11.01.63.3-0.51.8-1.4-1.51.21.01.1
Distance moved, locomotor task time 10.20.71.30.4-1.10.81.0-0.8-0.6-0.9
Vertical activity count, locomotor time 10.00.10.2-0.3-0.40.30.3-0.3-0.0-0.0
Time >=10cm from walls, locomotor time 20.00.00.20.0-0.00.20.00.10.0-0.4
Bouts of movement, locomotor time 20.20.71.50.6-0.71.20.7-1.0-0.8-0.3
Total resting periods, locomotor time 20.10.50.90.0-0.61.00.7-0.8-0.8-0.4
Rest time, locomotor task time 20.40.72.2-0.20.9-1.5-0.71.10.40.1
Distance moved, locomotor task time 20.20.21.2-0.3-0.11.10.0-0.30.30.1
Vertical activity count, locomotor time 20.20.40.9-0.90.10.8-0.20.00.70.7
Light reinforcement 10.10.20.70.1-0.90.30.6-0.2-0.4-0.4
Light reinforcement 20.51.12.6-1.6-0.80.70.8-1.1-1.2-0.6
Bone: marrow area0.61.44.4-2.1-1.01.40.8-1.0-0.60.0
Bone: maximum diameter1.32.65.3-0.8-2.32.11.7-1.5-1.3-0.8
Bone: maximum force0.51.02.8-1.7-1.10.90.8-1.1-0.70.1
Bone: maximum moment0.71.32.7-1.6-1.31.11.0-1.2-0.9-0.1
Mean time between licks in bursts0.10.32.0-1.40.2-0.0-0.30.20.20.4
Mean num. licks in bursts0.00.10.20.3-0.30.50.10.40.40.2
Cd content in liver0.50.51.8-0.2-0.91.30.6-0.7-0.30.3
Co content in liver1.82.13.1-0.11.5-1.7-1.61.81.51.2
Cu content in liver0.30.41.41.2-0.40.20.4-0.1-0.4-0.8
Fe content in liver0.20.20.50.6-0.20.10.4-0.4-0.6-0.7
K content in liver1.61.54.80.30.8-0.4-1.30.91.62.2
Mg content in liver0.10.10.30.0-0.0-0.2-0.30.40.30.5
Mn content in liver0.20.20.8-0.90.00.00.1-0.6-0.10.5
Na content in liver0.30.30.90.9-0.90.70.5-0.2-0.1-0.1
Rb content in liver4.35.07.51.72.2-2.7-2.42.72.21.5
Se content in liver0.80.91.4-0.2-1.00.91.1-1.2-1.1-0.8
Sr content in liver0.10.10.30.3-0.20.10.4-0.2-0.2-0.5
Zn content in liver0.10.10.2-0.4-0.30.30.3-0.0-0.3-0.4
Bone: minimum diameter0.40.72.0-0.7-0.81.40.3-0.50.31.2
Time in familiar zone, hab. session 10.30.40.80.1-0.50.30.7-0.5-0.8-0.9
Time in novel zone, hab. session 12.02.24.3-0.31.5-1.1-1.71.31.72.1
Total zone transitions, hab. session 14.36.09.30.93.0-3.0-2.82.72.31.6
Total locomotion distance, hab. session 12.13.04.0-0.01.9-1.8-2.01.91.71.9
Locomotion velocity, hab. session 11.62.23.3-0.21.7-1.8-1.71.71.31.3
Time in familiar zone, hab. session 20.20.20.8-0.5-0.2-0.10.3-0.1-0.5-0.9
Time in novel zone, hab. session 20.10.10.50.30.30.1-0.3-0.10.20.7
Total zone transitions, hab. session 21.72.13.31.11.6-1.7-1.51.81.40.8
Total locomotion distance, hab. session 21.72.23.2-0.31.7-1.8-1.71.81.31.2
Locomotion velocity, hab. session 21.41.93.4-0.11.6-1.8-1.51.71.10.8
Novel to familiar place preference ratio1.01.42.00.91.4-1.4-1.31.21.00.9
Novelty place preference1.01.31.91.01.3-1.4-1.21.20.90.8
Time in novel zone, NPP test1.11.41.80.81.3-1.3-1.31.21.01.1
Total zone transitions, NPP test0.71.11.7-0.91.3-1.2-1.20.70.80.9
Total locomotion distance, NPP test1.31.83.1-0.71.4-1.2-1.51.31.31.8
Locomotion velocity, NPP test0.81.21.7-0.61.3-1.3-1.21.10.91.1
Intraocular pressure0.30.53.0-1.70.3-0.10.0-0.2-0.3-0.5
Delta distance traveled before/after self-admin0.30.30.70.8-0.6-0.20.6-0.2-0.7-0.6
Delta ambulatory time before/after self-admin0.10.30.50.2-0.6-0.60.5-0.0-0.7-0.6
Parametrial fat weight0.20.42.0-1.4-0.10.3-0.0-0.60.10.7
Pavlov. Cond. lever latency0.60.84.52.1-0.60.50.40.0-0.0-0.5
Pavlov. Cond. magazine entry latency1.21.52.4-1.6-1.01.21.2-1.3-1.4-0.8
Pavlov. Cond. change in total contacts0.70.83.7-1.9-0.30.80.1-0.40.00.9
Pavlov. Cond. index score1.21.54.9-2.2-0.91.10.9-1.3-1.1-0.3
Pavlov. Cond. latency score0.91.25.3-2.3-0.50.60.6-1.0-0.9-0.2
Pavlov. Cond. lever contacts0.70.84.9-2.20.5-0.2-0.3-0.2-0.00.7
Pavlov. Cond. magazine entry number2.02.63.92.01.6-2.0-1.51.81.40.4
Pavlov. Cond. intertrial magazine entries4.14.96.02.22.4-1.9-2.32.42.31.8
Pavlov. Cond. lever-magazine prob. diff.1.11.44.7-2.2-0.81.10.8-1.2-0.9-0.1
Pavlov. Cond. response bias1.11.43.8-2.0-0.91.30.9-1.2-1.0-0.2
Pavlov. Cond. lever latency1.21.72.40.8-1.61.31.5-0.9-1.3-1.4
Pavlov. Cond. magazine entry latency1.52.14.1-0.12.0-2.0-1.71.41.20.7
Pavlov. Cond. change in total contacts0.00.10.1-0.30.4-0.2-0.3-0.20.20.3
Pavlov. Cond. index score0.71.11.8-0.71.3-1.1-1.30.71.01.1
Pavlov. Cond. latency score0.71.11.9-0.61.4-1.2-1.30.71.01.0
Pavlov. Cond. lever contacts1.21.82.5-0.71.5-1.3-1.60.91.41.6
Pavlov. Cond. magazine entry number0.91.12.20.3-1.51.51.3-0.9-0.8-0.5
Pavlov. Cond. intertrial magazine entries0.30.61.3-1.1-0.91.10.5-0.6-0.20.3
Pavlov. Cond. lever-magazine prob. diff.0.91.32.1-0.71.5-1.2-1.40.71.21.3
Pavlov. Cond. response bias1.21.62.5-0.81.6-1.4-1.50.81.21.3
Time in closed arm before self-admin1.52.618.2-4.3-0.0-0.00.1-0.1-0.4-0.1
Time in closed arm after self-admin2.62.99.93.1-0.90.81.3-1.1-1.6-1.8
Time in open arm before self-admin2.12.514.83.8-0.91.00.8-0.3-0.4-0.2
Time in open arm after self-admin0.20.20.7-0.8-0.0-0.4-0.20.40.20.5
Bone: periosteal estimation1.02.34.9-1.6-1.92.21.3-1.6-0.80.3
Bone: periosteal perimeter1.53.07.0-0.7-2.42.71.8-1.7-1.3-0.3
Bone: post-yield work0.00.10.1-0.4-0.2-0.20.10.3-0.1-0.2
Progressive ratio test 1 active lever presses3.56.230.05.51.6-2.3-1.51.51.00.5
Progressive ratio test 1 breakpoint3.66.129.15.41.6-2.3-1.51.51.00.6
Progressive ratio test 1 inactive lever presses2.15.49.12.62.2-3.0-2.32.51.91.6
Progressive ratio test 2 active lever presses6.69.312.92.93.5-3.3-3.13.62.91.6
Progressive ratio test 2 breakpoint7.08.912.13.03.4-3.3-3.03.52.81.5
Progressive ratio test 2 inactive lever presses2.06.47.92.82.6-2.0-2.62.82.72.1
Incentive Sensitization - Responses1.64.47.9-1.02.6-2.1-2.22.82.11.1
Incentive Sensitization - Breakpoint2.04.58.4-1.02.6-2.1-2.22.92.21.1
Sum of active levers in priming session hrs 5-60.20.20.50.60.5-0.7-0.2-0.1-0.1-0.2
Progressive ratio0.41.12.7-1.40.7-0.4-1.00.41.01.6
Food seeking constrained by brief footshock0.70.92.3-1.5-1.00.80.10.30.91.3
Seeking ratio, punishment vs. effort0.30.61.60.2-1.30.91.0-0.2-0.4-0.8
Retroperitoneal fat weight0.83.66.1-0.3-2.52.32.2-2.3-1.4-1.4
Reaction time number correct0.10.51.1-0.6-1.00.50.9-0.3-0.5-0.7
Reaction time mean minus median0.21.13.3-1.11.4-1.8-1.00.60.00.1
Reaction time mean minus median AUC0.10.71.9-0.81.1-1.4-0.80.30.10.3
Reaction time num false alarms2.33.95.91.3-2.01.62.3-1.9-2.1-2.4
Reaction time num false alarms AUC1.63.66.01.0-1.91.52.2-1.8-2.0-2.5
Reaction time trials correct on left0.10.51.1-0.6-1.00.50.9-0.3-0.5-0.7
Reaction time trials on left0.10.51.1-0.6-1.00.50.9-0.3-0.5-0.8
Reaction time mean0.30.71.9-0.90.7-1.4-0.1-0.3-1.0-0.9
Reaction time mean AUC0.41.03.1-1.11.2-1.8-0.6-0.1-0.6-0.5
Median of all reaction times0.40.61.2-0.80.3-0.90.2-0.6-1.1-1.1
Reaction time omissions0.40.62.1-0.20.0-1.00.2-0.2-1.0-1.5
Reaction time false alarm rate2.02.74.31.2-1.41.31.8-1.7-1.8-2.1
Reaction time premature initiation rate1.21.83.1-1.00.9-1.0-1.31.51.81.8
Reaction time premature initiations0.31.02.2-1.50.2-0.5-0.71.01.21.1
Std. dev. reaction times0.20.71.9-0.70.9-1.4-0.2-0.3-1.0-0.8
Reaction time trials completed0.10.51.1-0.6-1.00.50.9-0.3-0.5-0.8
Reaction time trials AUC0.10.51.2-0.5-1.10.50.9-0.3-0.5-0.8
Run reversals in cocaine runway, females0.70.71.60.3-0.51.00.8-1.3-1.1-0.6
Run reversals in cocaine runway, males0.20.20.50.7-0.60.40.4-0.0-0.1-0.2
Latency to leave start box in cocaine runway0.81.14.6-2.1-1.0-0.10.8-0.6-1.0-0.4
Latency to leave start box in cocaine runway, F0.40.52.5-1.6-0.7-0.10.5-0.2-0.6-0.0
Latency to leave start box in cocaine runway, M0.60.52.4-1.5-0.5-0.10.4-0.5-0.7-0.6
Std. dev. time between licks in bursts0.61.11.90.41.0-0.8-1.21.21.41.2
Total sessions with >9 infusions3.44.26.22.52.2-2.3-2.11.91.61.6
Short access day 1 total inactive lever presses0.40.71.6-0.00.5-0.6-0.81.31.01.1
Short access day 10 total inactive lever presses0.42.516.3-4.00.4-0.6-0.40.00.00.8
Short access day 1 total infusions1.83.55.1-0.02.0-2.3-2.12.21.81.8
Short access day 10 total infusions2.44.06.22.42.0-2.5-2.02.01.51.2
Short access total infusions3.95.67.12.62.3-2.7-2.42.42.11.9
Short access day 1 locomotion1.93.14.21.42.1-2.0-1.92.01.61.2
Short access day 10 total locomotion0.31.38.72.9-0.2-0.40.00.1-0.4-0.3
Short access total locomotion1.42.18.12.91.1-1.7-1.10.80.50.5
One hour access (0.3 mA shock)5.56.610.83.32.5-2.4-2.42.92.61.5
Compulsive drug intake0.81.23.2-1.8-1.11.11.1-0.8-0.9-0.2
One hour access (shock baseline)2.05.314.73.82.2-2.2-2.02.22.00.4
Social response proportion0.81.01.80.80.6-0.6-0.81.31.31.3
Social responses0.50.72.30.40.70.1-0.70.41.11.5
Social time1.01.62.61.61.6-1.2-1.30.91.10.9
Soleus weight0.51.63.5-0.1-1.40.91.5-1.0-1.3-1.9
Bone: stiffness0.71.32.4-1.6-1.51.21.1-1.1-0.8-0.1
Tibialis anterior weight0.00.10.3-0.10.3-0.5-0.00.0-0.2-0.6
Time to tail flick, vehicle, before self-admin0.30.32.11.40.10.30.0-0.40.0-0.2
Time to tail flick, vehicle, after self-admin0.00.10.20.40.3-0.3-0.30.20.20.1
Time to tail flick, test, before self-admin1.21.48.7-3.0-0.30.40.4-0.3-0.6-0.1
Time to tail flick, test, after self-admin4.44.77.2-2.7-1.61.62.1-2.6-2.6-1.6
Delta time to tail flick, vehicle, before/after SA0.40.51.0-0.10.8-1.0-0.70.90.50.4
Delta time to tail flick, test, before/after SA0.50.61.20.4-0.60.30.7-1.1-1.1-0.7
Tibia length0.10.40.9-0.7-0.80.80.2-0.40.21.0
Ambulatory time before self-admin0.61.89.7-3.10.50.9-0.5-0.40.51.2
Ambulatory time after self-admin0.60.95.2-2.30.3-0.2-0.40.10.20.8
Bone: tissue strength0.80.91.8-0.1-0.80.51.1-1.1-1.1-1.3
Total heroin consumption0.30.30.80.5-0.30.30.6-0.5-0.7-0.9
Bone: trabecular number0.51.01.6-0.51.1-0.8-1.30.91.11.2
Bone: trabecular spacing0.30.41.4-0.0-0.40.10.7-0.5-0.8-1.2
Bone: trabecular thickness0.10.10.3-0.6-0.0-0.2-0.30.30.20.5
Bone: trabecular tissue density0.61.02.3-1.5-0.51.50.3-1.00.11.1
Water consumed over 24 hours0.30.71.5-0.7-0.71.00.8-1.2-0.7-0.1
Number of responses in last shaping day0.20.20.60.60.30.80.1-0.5-0.2-0.5