Hub : Genes

Grap2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Grap2	0.1	0.06	1.4e-04	0.06	0.05	0.03	0.05	5.4e-04	1.3e-03	1.5e-02	7.6e-04
2	BLA	gene expression	Grap2	0.06	0.04	5.1e-03	0.02	0.03	0.02	0.01	3.4e-02	1.0e-02	4.4e-02	5.3e-02
3	NAcc	gene expression	Grap2	0.1	0.06	7.1e-08	0.08	0.06	0.06	0.07	4.1e-09	1.3e-07	5.0e-07	1.3e-08
4	Brain	mRNA stability	Grap2	0.08	0.05	7.9e-05	0.01	0.04	0.03	0.02	3.0e-02	4.5e-05	9.6e-04	4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.3	0.6	-0.1	0.5	0.1
Area under the delay curve	2.0	2.2	3.5	1.4	-0.7	1.9	-1.7
BMI with tail	1.3	4.1	5.9	-1.6	2.1	-1.9	2.4
BMI without tail	0.3	0.7	2.2	0.1	0.3	-0.7	1.5
Body weight	1.8	7.5	9.3	-3.0	3.0	-2.1	2.6
Weight adjusted by age	0.3	0.4	0.6	0.5	-0.8	-0.2	-0.7
Bone surface	0.3	0.5	1.1	0.4	-0.0	1.0	-0.8
Bone volume	0.0	0.1	0.2	0.3	0.2	0.4	-0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.1	0.2	0.5	0.3
Number of licking bursts	1.7	2.0	2.7	1.4	-1.3	1.3	-1.7
Context. condit. distance diff. score	6.3	7.5	12.7	-2.6	1.7	-3.6	2.7
Locomotion velocity, session 1	0.9	1.0	2.5	0.1	0.0	1.2	-1.6
Locomotion distance, session 1	4.7	6.0	8.9	2.4	-1.7	2.5	-3.0
Locomotion velocity, session 2	0.3	0.3	0.6	-0.7	0.8	-0.0	0.3
Locomotion distance, session 2	3.8	5.3	9.6	2.1	-1.0	3.1	-2.5
Locomotion velocity, session 3	0.3	0.4	1.5	-0.2	-0.3	-1.2	0.1
Locomotion distance, session 3	2.6	2.8	4.0	1.9	-2.0	0.4	-1.9
Stereotopy head waving bouts, day 3	1.0	1.1	2.4	-1.3	1.5	-0.1	0.8
Stereotopy head waving duration, day 3	3.6	4.4	6.3	-2.5	2.5	-1.0	1.9
Locomotion velocity, session 7	0.5	0.6	1.3	-1.2	0.5	-0.7	0.4
Locomotion distance, session 7	0.2	0.3	0.6	-0.1	0.3	0.7	-0.7
Stereotopy head waving bouts, day 7	2.9	3.3	4.7	-2.2	1.4	-1.8	1.8
Stereotopy head waving duration, day 7	3.3	4.0	5.8	-1.9	1.1	-2.4	2.3
Locomotion velocity, session 8	1.4	1.6	2.7	-1.6	1.6	-0.7	0.8
Locomotion distance, session 8	0.6	0.9	1.9	-0.6	0.4	-1.4	1.1
Degree of sensitization distance	4.3	4.3	6.2	-2.5	2.5	-0.8	2.1
Degree of sensitization stereotypy	1.9	2.1	3.9	-1.4	0.7	-2.0	1.4
Conditioned locomotion	0.3	0.4	0.8	-0.5	0.4	-0.9	0.6
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.6	0.4	0.1	-0.0
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.5	0.3	0.0	0.2
Cocaine response before conditioning	0.1	0.1	0.3	0.2	-0.5	-0.2	0.3
Saline control response	0.3	0.4	0.9	0.1	-1.0	-0.8	0.3
Bone: connectivity density	0.0	0.1	0.2	0.1	0.1	0.5	-0.1
Bone: cortical apparent density	0.9	1.2	2.0	1.1	-1.4	0.3	-1.3
Bone: cortical area	1.2	1.8	3.8	-1.3	2.0	-0.5	1.1
Bone: cortical porosity	2.2	2.5	3.5	-1.9	1.5	-0.9	1.8
Bone: cortical porosity	3.4	3.7	5.8	-2.4	2.0	-1.0	2.0
Bone: cortical thickness	0.1	0.2	0.7	-0.0	0.8	0.1	0.2
Bone: cortical thickness	0.2	0.3	0.5	0.4	0.7	0.6	-0.4
Bone: cortical tissue density	0.9	1.2	1.9	1.1	-1.4	0.3	-1.3
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.4	-0.3	0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1
Condit. Reinf. active responses	1.1	1.4	1.8	1.2	-1.2	1.3	-1.0
Condit. Reinf. inactive responses	1.7	2.1	2.8	1.6	-1.7	1.4	-0.9
Incentive salience index mean	0.6	0.7	1.1	0.8	-0.6	1.0	-0.9
Condit. Reinf. lever presses	0.4	0.6	1.1	0.8	-0.6	1.1	-0.6
Condit. Reinf. active minus inactive responses	0.9	1.1	2.2	0.1	0.1	1.5	-1.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.1	-0.4	0.8	1.0	-0.6
Condit. Reinf. active responses	0.4	0.6	0.9	-0.7	0.6	0.8	-1.0
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.5	0.4	0.0	-0.5
Condit. Reinf. lever presses	0.4	0.6	1.0	0.8	-0.5	1.0	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	-0.7	0.5	0.9	-0.9
Conditioned reinforcement - actives	1.0	1.0	2.7	0.8	-0.6	0.5	-1.7
Conditioned reinforcement - inactives	1.5	1.7	3.3	1.2	-0.4	1.8	-1.4
Conditioned locomotion	0.4	0.5	1.4	-0.6	1.2	0.4	-0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.6	-0.2	0.7	0.0
Patch foraging indifference point AUC	2.6	3.0	6.2	1.5	-0.8	1.7	-2.5
Delay disc. indifference point, 0s delay	1.1	1.2	2.1	-0.9	1.4	-0.3	1.4
Delay disc. indifference point, 16s delay	4.0	4.0	5.5	1.9	-1.3	2.3	-2.3
Delay disc. indifference point, 2s delay	0.3	0.4	0.9	0.4	0.2	0.9	-0.6
Delay disc. indifference point, 24s delay	2.7	2.6	5.2	1.2	-0.5	1.9	-2.3
Delay disc. indifference point, 4s delay	0.9	0.9	2.3	0.7	0.1	1.5	-0.9
Delay disc. indifference point, 8s delay	2.6	2.7	3.5	1.8	-1.1	1.9	-1.8
Indifference point function ln k	3.0	4.2	6.0	-2.1	1.2	-2.3	2.4
Indifference point function log k	3.0	4.2	6.0	-2.1	1.2	-2.3	2.4
Patch foraging total patch changes 0 sec	0.2	0.4	0.8	0.9	-0.4	0.8	-0.0
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	-0.0	0.2	0.6	-0.6
Patch foraging total patch changes 18 sec	0.7	0.9	2.4	0.5	0.4	1.5	-0.9
Patch foraging total patch changes 24 sec	0.7	0.9	1.3	0.9	-0.5	1.2	-1.0
Patch foraging total patch changes 6 sec	1.4	2.1	4.8	1.4	-0.1	2.2	-1.3
Patch foraging time to switch 0 sec	1.0	1.5	2.8	-1.7	1.0	-0.5	1.4
Patch foraging water rate 0 sec	0.4	0.7	2.0	1.4	-0.4	0.6	-0.4
Patch foraging water rate 12 sec	0.2	0.3	0.7	0.6	-0.9	0.3	0.1
Patch foraging water rate 18 sec	1.2	1.6	2.4	1.5	-0.9	1.5	-1.1
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.6	0.4	-0.5	0.8
Patch foraging water rate 6 sec	1.2	1.7	3.6	1.5	-1.9	0.4	-1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.7	0.7	-0.7	0.8	-0.3
Distance traveled before self-admin	0.1	0.1	0.2	0.4	-0.0	0.4	-0.1
Distance traveled after self-admin	0.6	0.7	2.0	0.1	0.7	1.4	-0.4
Extensor digitorum longus weight	0.3	1.0	2.9	1.7	-1.0	0.1	0.1
Bone: elastic displacement	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.1
Bone: elastic work	2.3	3.0	4.9	-1.9	2.2	-0.8	1.7
Bone: endosteal estimation	0.9	2.0	3.6	-1.9	1.8	-0.3	1.0
Bone: endosteal perimeter	1.9	3.9	6.3	-2.5	2.1	-1.2	1.8
Epididymis fat weight	3.2	7.5	10.1	-3.2	2.4	-2.9	2.3
Delta time in closed arm before/after self-admin	0.5	0.5	0.8	-0.8	0.9	-0.7	0.1
Delta time in open arm before/after self-admin	0.3	0.2	0.4	0.5	-0.5	0.7	-0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	0.8	0.3	0.0	0.7	-0.9
Delay discount exponential model param	2.3	2.5	3.7	-1.5	0.8	-1.9	1.8
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.4	0.0	0.8	-0.6
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.4	0.6	0.1	0.3
Bone: final force	1.4	2.3	6.2	-1.4	2.5	-0.2	1.0
Bone: final moment	1.5	2.4	6.6	-1.4	2.6	-0.1	1.0
Food consumed during 24 hour testing period	1.4	1.7	3.8	-1.2	1.9	-0.7	1.1
Glucose	0.2	0.3	0.6	-0.8	0.2	0.2	0.6
Heart weight	1.6	2.3	3.8	-1.2	1.6	-1.1	1.9
Delay discount hyperbolic model param	1.9	2.0	3.4	-1.4	0.6	-1.8	1.6
Intermittent access intake day 1-15 change	1.3	1.3	1.9	1.4	-1.4	0.4	-1.1
Intermittent access intake escalation	1.1	1.1	1.6	1.3	-1.2	0.5	-0.9
Intermittent access intake escalation 2	0.5	0.5	0.9	0.9	-0.8	0.3	-0.5
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.6	-0.4	0.8	0.3	0.5
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.3	0.4	0.9	-0.8
Intermitt. access escalation Index	0.1	0.1	0.3	0.5	-0.4	0.1	-0.2
Intermittent access day 1 total infusions	0.5	0.5	1.4	-0.8	1.2	0.4	-0.1
Intermittent access day 15 total infusions	0.6	0.6	1.3	0.6	-0.1	1.1	-1.0
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.9	0.4	-0.2	0.7	-0.9
Intermittent access total infusions	0.4	0.4	0.7	-0.3	0.8	0.8	-0.4
Intermittent access day 1 locomotion	0.3	0.4	1.0	-0.6	1.0	0.2	0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.7	-0.6	0.8	0.3	-0.0
Intermittent access total locomotion	0.7	0.8	1.9	-1.0	1.4	0.4	0.2
Intermittent access standard deviation	0.3	0.4	0.8	-0.5	0.9	0.1	0.6
Left kidney weight	7.8	21.9	31.7	-5.6	5.2	-4.0	3.6
Right kidney weight	8.1	22.7	33.0	-5.7	5.7	-3.5	3.6
Cocaine induced anxiety	2.6	3.0	3.8	-1.8	1.8	-1.3	1.9
Post-drug Anxiety	1.2	1.3	1.7	-1.3	1.3	-0.5	1.2
Baseline Anxiety	1.8	1.9	2.2	1.3	-1.4	1.3	-1.5
Tail length	0.0	0.1	0.2	0.1	-0.4	-0.1	0.1
Length with tail	0.5	1.8	3.9	-2.0	1.3	-0.9	0.7
Length without tail	1.2	2.7	6.4	-2.5	1.9	-0.8	0.3
Times rat made contact with spout	0.3	0.3	0.8	0.9	0.3	0.2	-0.5
Lifetime Intake	0.7	0.8	2.0	-0.9	1.4	0.6	0.0
Liver weight, left	0.9	1.5	2.8	-1.3	0.6	-1.7	1.1
Liver weight, right	3.6	6.0	11.0	-2.8	1.0	-3.3	2.1
Locomotor activity	1.2	2.0	2.6	-1.6	1.5	-1.2	1.3
Locomotor testing distance	0.0	0.1	0.1	0.3	-0.4	-0.2	-0.1
Locomotor testing rearing	1.3	1.9	2.7	-1.6	1.2	-1.4	1.3
Locomotion in novel chamber	3.4	4.1	8.8	2.5	-3.0	0.3	-1.3
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	0.9	-1.0	0.3	-0.5
Fecal boli incidents, locomotor time 1	1.0	1.1	2.7	0.7	0.1	1.6	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.3	0.7	-0.0	-0.4	-0.8	-0.7
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.2	-1.0	1.1	-0.1	0.4
Bouts of movement, locomotor time 1	0.6	0.6	1.0	-0.9	1.0	-0.8	0.3
Total resting periods, locomotor time 1	0.4	0.4	1.0	-0.7	1.0	-0.5	0.3
Rest time, locomotor task time 1	0.5	0.5	1.2	-0.8	1.1	-0.2	0.4
Distance moved, locomotor task time 1	0.6	0.6	1.4	-0.6	0.0	-1.2	0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.2	-0.2	0.1	-0.0	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.1	0.2	0.4	-0.1
Bouts of movement, locomotor time 2	0.5	0.6	0.8	-0.9	0.7	-0.6	0.8
Total resting periods, locomotor time 2	0.3	0.3	0.5	-0.7	0.7	-0.2	0.5
Rest time, locomotor task time 2	0.5	0.5	1.0	0.5	-0.2	0.9	-1.0
Distance moved, locomotor task time 2	1.1	1.2	2.3	-0.9	0.4	-1.5	1.2
Vertical activity count, locomotor time 2	0.6	0.6	0.8	-0.9	0.8	-0.6	0.9
Light reinforcement 1	0.0	0.1	0.1	-0.0	-0.1	0.4	-0.2
Light reinforcement 2	1.4	1.9	3.8	-1.3	0.5	-1.9	1.5
Bone: marrow area	1.0	2.2	3.8	-2.0	1.9	-0.3	1.0
Bone: maximum diameter	3.4	6.2	10.9	-2.8	3.3	-1.1	2.1
Bone: maximum force	2.1	3.6	9.7	-1.8	3.1	-0.3	1.2
Bone: maximum moment	2.2	3.8	10.3	-1.9	3.2	-0.3	1.2
Mean time between licks in bursts	0.4	0.6	1.1	1.1	-1.0	0.4	-0.3
Mean num. licks in bursts	1.2	1.5	1.8	-0.9	1.3	-1.4	1.2
Cd content in liver	0.6	0.6	1.7	0.2	0.0	-1.3	0.9
Co content in liver	0.2	0.3	0.5	0.6	0.5	-0.3	0.7
Cu content in liver	2.8	3.4	5.9	2.4	-1.7	1.8	-1.2
Fe content in liver	0.7	0.8	1.3	-1.0	0.8	-0.2	1.2
K content in liver	0.3	0.3	0.8	0.3	-0.4	0.9	-0.5
Mg content in liver	0.4	0.4	1.3	0.0	-0.2	1.2	-0.3
Mn content in liver	0.1	0.2	0.4	0.2	-0.4	-0.7	-0.1
Na content in liver	1.1	1.1	1.4	1.2	-1.1	1.2	-0.7
Rb content in liver	0.2	0.2	0.4	0.5	0.2	0.6	-0.2
Se content in liver	1.0	1.3	2.5	1.5	-1.6	-0.2	-0.4
Sr content in liver	2.6	2.4	6.0	2.4	-1.7	0.1	-0.9
Zn content in liver	0.9	1.0	1.5	1.1	-1.2	0.9	-0.8
Bone: minimum diameter	0.9	1.6	2.9	-1.7	1.7	-0.2	0.9
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.5	0.3	0.8	-0.9
Time in novel zone, hab. session 1	1.6	1.6	2.5	-1.3	0.4	-1.4	1.6
Total zone transitions, hab. session 1	5.1	7.2	9.1	3.0	-2.9	1.7	-2.9
Total locomotion distance, hab. session 1	2.9	4.1	6.0	1.9	-2.5	1.2	-2.3
Locomotion velocity, hab. session 1	3.2	4.5	5.7	2.1	-2.3	1.5	-2.4
Time in familiar zone, hab. session 2	0.4	0.5	0.8	0.6	-0.9	-0.8	-0.1
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.5	0.8	0.6	0.1
Total zone transitions, hab. session 2	2.5	3.3	4.7	1.8	-0.8	2.2	-2.1
Total locomotion distance, hab. session 2	1.4	1.9	3.3	1.2	-0.8	1.8	-1.5
Locomotion velocity, hab. session 2	2.1	2.9	4.9	1.5	-1.0	2.2	-1.8
Novel to familiar place preference ratio	1.2	1.2	2.2	-0.9	0.8	-1.5	1.1
Novelty place preference	1.7	1.7	3.5	-1.0	0.9	-1.9	1.3
Time in novel zone, NPP test	2.0	2.0	4.0	-1.1	1.1	-2.0	1.4
Total zone transitions, NPP test	6.0	8.6	11.0	3.2	-2.8	2.2	-3.3
Total locomotion distance, NPP test	2.6	3.6	5.2	1.9	-1.6	1.7	-2.3
Locomotion velocity, NPP test	3.1	4.3	5.6	2.1	-2.0	1.8	-2.4
Intraocular pressure	0.4	0.6	1.6	-1.3	0.7	-0.5	0.1
Delta distance traveled before/after self-admin	0.3	0.4	0.6	-0.5	0.8	0.6	-0.3
Delta ambulatory time before/after self-admin	0.5	0.6	1.0	-0.5	0.9	1.0	-0.6
Parametrial fat weight	0.1	0.1	0.4	-0.2	0.2	-0.6	0.3
Pavlov. Cond. lever latency	0.3	0.3	0.5	-0.5	0.6	-0.7	0.4
Pavlov. Cond. magazine entry latency	0.7	0.8	1.4	1.1	-0.4	1.2	-0.8
Pavlov. Cond. change in total contacts	1.5	1.6	3.6	1.1	-0.4	1.9	-1.2
Pavlov. Cond. index score	0.2	0.3	0.7	0.3	-0.0	0.9	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.4	0.2	-0.1	0.7	-0.3
Pavlov. Cond. lever contacts	0.4	0.4	0.9	0.5	-0.6	0.9	-0.5
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	-0.9	0.5	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.5	1.2	-0.7	1.9	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.5	-0.3	0.9	-0.7
Pavlov. Cond. response bias	0.4	0.5	1.1	0.7	-0.3	1.0	-0.7
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.6	0.5	-1.0	-0.0
Pavlov. Cond. magazine entry latency	2.0	2.3	4.5	1.6	-0.8	2.1	-1.1
Pavlov. Cond. change in total contacts	0.7	1.0	3.1	-0.3	0.8	1.8	-0.1
Pavlov. Cond. index score	1.1	1.4	3.0	1.2	-0.8	1.7	-0.8
Pavlov. Cond. latency score	1.5	1.8	3.8	1.4	-0.8	1.9	-1.0
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.5	-0.5	0.8	0.1
Pavlov. Cond. magazine entry number	0.9	1.1	2.2	-1.2	0.4	-1.5	0.7
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.6	-1.1	1.3	-0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.8	1.2	-0.7	1.7	-0.7
Pavlov. Cond. response bias	0.4	0.5	1.7	0.6	-0.2	1.3	-0.1
Time in closed arm before self-admin	1.5	1.6	4.7	1.2	-0.6	2.2	-0.1
Time in closed arm after self-admin	1.0	1.0	1.8	-1.1	1.4	-0.2	0.9
Time in open arm before self-admin	0.4	0.5	1.3	0.2	-0.6	-1.1	-0.3
Time in open arm after self-admin	0.5	0.5	1.4	0.7	-1.2	-0.3	-0.1
Bone: periosteal estimation	1.6	3.3	6.1	-2.1	2.5	-0.6	1.4
Bone: periosteal perimeter	3.5	5.9	8.4	-2.9	2.9	-1.4	2.2
Bone: post-yield work	0.6	0.8	1.4	0.0	1.1	1.2	-0.6
Progressive ratio test 1 active lever presses	0.5	0.5	0.9	-0.2	0.9	0.9	-0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	0.0	0.5	0.7	-0.6
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.2	0.6	0.5	0.3
Progressive ratio test 2 active lever presses	0.8	0.8	1.8	0.3	0.0	1.2	-1.3
Progressive ratio test 2 breakpoint	0.5	0.6	1.1	0.0	0.3	1.0	-1.1
Progressive ratio test 2 inactive lever presses	1.3	1.5	2.7	1.0	-0.5	1.6	-1.4
Incentive Sensitization - Responses	0.5	0.5	0.8	0.5	-0.8	0.5	-0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.3	-0.6	0.4	-0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	-0.2	0.2	0.1
Progressive ratio	0.2	0.2	0.7	0.2	0.0	0.8	-0.2
Food seeking constrained by brief footshock	0.3	0.4	1.0	-0.7	1.0	-0.1	0.3
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.5	0.6	-0.3	0.3
Retroperitoneal fat weight	4.4	14.4	21.7	-4.7	3.5	-3.7	3.2
Reaction time number correct	0.9	1.3	2.8	1.1	-1.7	0.0	-1.1
Reaction time mean minus median	0.1	0.1	0.2	-0.2	0.1	-0.4	0.5
Reaction time mean minus median AUC	0.9	1.2	1.8	-1.0	0.5	-1.3	1.2
Reaction time num false alarms	0.0	0.1	0.2	0.0	-0.2	-0.2	0.5
Reaction time num false alarms AUC	0.1	0.1	0.3	0.3	-0.6	0.0	0.0
Reaction time trials correct on left	0.9	1.3	2.8	1.1	-1.7	0.0	-1.1
Reaction time trials on left	1.0	1.4	3.1	1.2	-1.7	0.1	-1.1
Reaction time mean	0.1	0.1	0.4	-0.3	-0.0	-0.2	0.6
Reaction time mean AUC	0.1	0.1	0.2	-0.2	-0.1	-0.2	0.4
Median of all reaction times	0.0	0.1	0.2	-0.2	-0.2	0.0	0.4
Reaction time omissions	0.3	0.5	0.9	0.7	-0.9	0.2	-0.6
Reaction time false alarm rate	0.1	0.2	0.5	-0.2	0.3	-0.2	0.7
Reaction time premature initiation rate	0.5	0.7	1.3	-0.7	1.0	1.1	0.4
Reaction time premature initiations	0.2	0.2	0.7	-0.2	0.3	0.9	-0.0
Std. dev. reaction times	0.4	0.5	0.7	-0.7	0.4	-0.8	0.8
Reaction time trials completed	1.0	1.4	3.1	1.2	-1.7	0.1	-1.1
Reaction time trials AUC	0.6	0.9	2.0	0.8	-1.4	-0.1	-0.9
Run reversals in cocaine runway, females	0.5	0.4	1.2	0.5	-1.1	0.2	-0.5
Run reversals in cocaine runway, males	0.3	0.3	0.9	0.2	0.0	-0.3	-1.0
Latency to leave start box in cocaine runway	2.0	2.1	3.4	-1.5	0.8	-1.9	1.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	-0.2	-0.1	-0.7	0.5
Latency to leave start box in cocaine runway, M	3.8	3.6	4.7	-2.1	1.4	-2.2	1.9
Std. dev. time between licks in bursts	1.0	1.2	2.7	1.0	-0.6	1.7	-0.9
Total sessions with >9 infusions	1.3	1.5	3.3	-1.6	1.8	0.1	0.4
Short access day 1 total inactive lever presses	1.1	1.2	3.2	-0.1	1.2	1.8	-0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.0	0.2	0.1	-0.0
Short access day 1 total infusions	0.5	0.5	1.2	-0.8	1.1	0.1	0.4
Short access day 10 total infusions	1.9	2.1	4.5	-1.7	2.1	-0.3	1.0
Short access total infusions	2.2	2.5	5.3	-1.9	2.3	-0.1	1.0
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	0.5	0.3	0.3
Short access day 10 total locomotion	0.1	0.1	0.5	0.0	0.1	-0.2	0.7
Short access total locomotion	1.3	1.4	2.5	-1.3	1.6	-0.4	1.1
One hour access (0.3 mA shock)	1.1	1.3	2.0	1.2	-0.8	1.0	-1.4
Compulsive drug intake	4.3	4.3	6.3	2.2	-2.1	1.4	-2.5
One hour access (shock baseline)	0.2	0.3	0.4	-0.5	0.7	-0.2	0.6
Social response proportion	0.9	0.9	2.4	-0.7	0.7	-0.6	1.5
Social responses	0.3	0.4	0.7	0.5	-0.4	0.8	-0.8
Social time	1.6	2.1	3.1	1.3	-1.3	1.8	-1.3
Soleus weight	0.7	2.2	3.7	1.4	-0.9	1.5	-1.9
Bone: stiffness	2.0	3.1	7.3	-1.8	2.7	-0.2	1.4
Tibialis anterior weight	0.9	3.0	6.7	2.6	-1.3	1.5	-1.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.2	0.1	0.4	-0.7
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.8	0.8	-0.9	0.2	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.2	-0.3	0.0	-0.6
Time to tail flick, test, after self-admin	1.2	1.2	1.6	1.2	-1.3	1.0	-0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.3	-0.2	-0.2	0.4
Delta time to tail flick, test, before/after SA	1.9	1.7	2.6	1.6	-1.6	1.0	-0.8
Tibia length	0.4	1.1	2.8	-1.3	1.7	-0.2	0.1
Ambulatory time before self-admin	0.5	0.5	0.9	1.0	-0.7	0.6	-0.6
Ambulatory time after self-admin	1.5	1.7	3.8	1.0	-0.4	1.9	-1.3
Bone: tissue strength	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1
Total heroin consumption	0.1	0.1	0.2	0.1	0.3	0.4	-0.5
Bone: trabecular number	0.1	0.1	0.4	0.0	-0.2	-0.6	0.3
Bone: trabecular spacing	0.7	1.0	2.7	-0.9	1.6	0.5	-0.0
Bone: trabecular thickness	0.2	0.3	0.6	0.1	-0.3	-0.6	0.8
Bone: trabecular tissue density	0.5	0.7	1.3	1.2	-0.7	0.9	0.1
Water consumed over 24 hours	0.2	0.2	0.5	0.7	0.5	0.1	-0.2
Number of responses in last shaping day	0.9	1.0	3.2	-0.2	0.8	1.8	0.0