Hub : Genes

Gpx7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr5_128377129_128377541 0.06 0.04 3.9e-06 0.05 0.06 0.06 0.05 1.8e-05 7.4e-06 7.8e-06 1.5e-05
2 NAcc gene expression Gpx7 0.08 0.06 3.8e-14 0.09 0.09 0.09 0.09 7.3e-13 9.3e-14 4.6e-13 2.1e-13
3 IC intron excision ratio chr5_128377129_128377541 0.08 0.06 1.2e-03 0.04 0.04 0.04 0.04 5.9e-03 5.6e-03 9.9e-03 8.0e-03
4 PL intron excision ratio chr5_128377129_128377541 0.08 0.06 2.1e-09 0.09 0.08 0.08 0.08 1.6e-09 7.1e-09 2.1e-09 3.6e-09
5 BLA intron excision ratio chr5_128377129_128377541 0.12 0.08 1.2e-05 0.09 0.08 0.08 0.07 3.0e-05 7.9e-05 5.4e-05 8.7e-05
6 pVTA intron excision ratio chr5_128377129_128377541 0.05 0.04 6.4e-04 0.04 0.04 0.04 0.04 2.9e-04 3.3e-04 2.9e-04 3.1e-04
7 LHb intron excision ratio chr5_128377609_128381533 0.16 0.12 8.6e-03 0.09 0.13 0.11 0.12 3.6e-03 6.4e-04 1.6e-03 1.2e-03
8 NAcc intron excision ratio chr5_128377129_128377541 0.05 0.04 3.8e-08 0.05 0.05 0.05 0.05 2.3e-08 6.5e-08 2.0e-08 4.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.01.11.0-1.11.11.11.01.0-0.60.9
Area under the delay curve0.10.10.50.1-0.00.0-0.20.10.10.70.3
BMI with tail1.44.86.2-2.32.3-2.3-2.1-2.5-2.4-0.1-2.5
BMI without tail0.72.12.6-1.61.6-1.6-1.4-1.6-1.60.2-1.6
Body weight0.83.34.2-2.02.0-1.9-1.7-2.0-2.0-0.0-2.0
Weight adjusted by age0.20.30.5-0.50.5-0.5-0.3-0.5-0.6-0.7-0.4
Bone surface0.20.30.40.6-0.60.60.50.70.7-0.00.6
Bone volume0.00.00.00.2-0.20.20.20.20.2-0.20.2
Breakpoint value in progressive ratio session0.00.00.10.1-0.10.10.20.10.1-0.20.0
Number of licking bursts0.20.30.8-0.40.3-0.3-0.2-0.5-0.5-0.9-0.6
Context. condit. distance diff. score0.50.61.00.8-0.80.81.00.60.7-0.90.7
Locomotion velocity, session 13.43.75.12.0-2.02.02.31.81.8-1.61.7
Locomotion distance, session 10.10.10.60.3-0.30.30.40.10.1-0.80.1
Locomotion velocity, session 23.13.75.02.0-2.02.02.21.71.8-1.81.7
Locomotion distance, session 20.71.01.4-1.01.0-1.0-1.2-0.8-0.81.0-0.9
Locomotion velocity, session 30.80.91.11.1-1.11.11.01.01.0-0.50.8
Locomotion distance, session 30.20.20.8-0.30.4-0.4-0.5-0.2-0.10.9-0.2
Stereotopy head waving bouts, day 30.10.10.70.1-0.20.20.3-0.0-0.0-0.8-0.2
Stereotopy head waving duration, day 30.60.72.70.7-0.70.71.10.40.3-1.60.1
Locomotion velocity, session 70.20.21.00.2-0.10.1-0.00.40.51.00.6
Locomotion distance, session 70.50.74.1-0.20.2-0.2-0.80.30.32.00.6
Stereotopy head waving bouts, day 71.71.92.61.5-1.51.51.61.31.3-1.11.1
Stereotopy head waving duration, day 71.82.23.01.6-1.61.61.71.41.4-1.31.1
Locomotion velocity, session 81.92.33.01.6-1.61.61.71.51.6-0.71.7
Locomotion distance, session 80.00.00.10.2-0.20.20.20.20.2-0.00.2
Degree of sensitization distance0.10.10.4-0.30.3-0.3-0.5-0.2-0.10.70.1
Degree of sensitization stereotypy0.91.01.31.1-1.11.11.11.11.0-0.60.7
Conditioned locomotion0.20.31.6-0.10.1-0.10.2-0.4-0.4-1.3-0.3
Cocaine response after cond. corrected2.32.83.8-1.81.8-1.8-2.0-1.5-1.51.5-1.6
Cocaine response after cond. not corrected2.83.34.1-1.92.0-2.0-2.0-1.8-1.81.2-1.8
Cocaine response before conditioning0.10.10.4-0.10.1-0.10.1-0.3-0.3-0.6-0.2
Saline control response0.40.63.3-0.30.3-0.3-0.90.10.11.80.4
Bone: connectivity density1.01.52.01.3-1.31.31.11.41.4-0.11.3
Bone: cortical apparent density2.12.83.71.8-1.81.81.91.61.6-1.21.6
Bone: cortical area1.21.92.5-1.51.5-1.5-1.6-1.4-1.40.8-1.2
Bone: cortical porosity0.60.74.10.4-0.40.50.9-0.0-0.0-2.0-0.0
Bone: cortical porosity0.90.93.60.8-0.80.81.20.40.4-1.90.4
Bone: cortical thickness2.44.04.9-2.22.2-2.2-2.0-2.2-2.20.4-2.0
Bone: cortical thickness1.72.12.8-1.51.5-1.5-1.3-1.7-1.7-0.4-1.4
Bone: cortical tissue density2.33.14.31.9-1.91.92.11.71.7-1.31.7
Condit. Reinf. active minus inactive responses0.60.60.8-0.90.8-0.8-0.8-0.9-0.80.1-0.9
Condit. Reinf. active-inactive response ratio0.70.80.9-1.01.0-1.0-0.9-1.0-0.90.3-0.9
Condit. Reinf. active responses1.11.41.7-1.31.3-1.3-1.2-1.3-1.30.2-1.3
Condit. Reinf. inactive responses0.10.10.2-0.30.4-0.4-0.5-0.3-0.20.4-0.1
Incentive salience index mean1.82.22.8-1.61.6-1.6-1.5-1.6-1.60.2-1.7
Condit. Reinf. lever presses1.72.43.1-1.71.6-1.6-1.6-1.7-1.70.2-1.8
Condit. Reinf. active minus inactive responses0.50.62.2-0.70.7-0.7-1.1-0.4-0.41.5-0.1
Condit. Reinf. active-inactive response ratio0.20.21.2-0.20.2-0.3-0.50.0-0.01.10.2
Condit. Reinf. active responses0.30.40.7-0.70.7-0.7-0.8-0.4-0.50.8-0.3
Condit. Reinf. inactive responses0.30.40.5-0.70.7-0.7-0.5-0.7-0.7-0.2-0.7
Condit. Reinf. lever presses0.30.42.00.3-0.20.2-0.30.60.61.40.5
Condit. Reinf. lever reinforcers received0.30.41.0-0.60.6-0.6-0.8-0.3-0.31.0-0.2
Conditioned reinforcement - actives2.23.74.9-2.02.0-2.0-2.2-1.7-1.72.1-1.6
Conditioned reinforcement - inactives0.10.10.1-0.30.3-0.3-0.3-0.3-0.30.1-0.3
Conditioned locomotion0.91.21.6-1.11.2-1.2-1.3-1.0-1.01.0-1.0
Patch foraging indifference point 0 sec0.30.60.8-0.90.9-0.9-0.8-0.8-0.80.5-0.8
Patch foraging indifference point AUC0.20.30.40.6-0.60.60.60.60.6-0.10.4
Delay disc. indifference point, 0s delay0.30.30.80.5-0.50.40.10.60.50.90.7
Delay disc. indifference point, 16s delay1.11.21.7-1.21.2-1.2-1.3-1.1-1.10.6-0.9
Delay disc. indifference point, 2s delay0.10.10.20.2-0.20.20.10.20.20.20.5
Delay disc. indifference point, 24s delay0.20.20.50.4-0.40.40.20.40.40.20.7
Delay disc. indifference point, 4s delay0.00.00.2-0.10.2-0.2-0.2-0.1-0.10.4-0.1
Delay disc. indifference point, 8s delay0.10.10.4-0.00.0-0.1-0.30.1-0.00.60.2
Indifference point function ln k0.30.60.7-0.80.8-0.8-0.8-0.8-0.80.2-0.7
Indifference point function log k0.30.60.7-0.80.8-0.8-0.8-0.8-0.80.2-0.7
Patch foraging total patch changes 0 sec0.30.50.7-0.80.8-0.8-0.7-0.8-0.70.3-0.7
Patch foraging total patch changes 12 sec0.91.21.41.2-1.21.21.11.21.2-0.31.1
Patch foraging total patch changes 18 sec0.20.40.6-0.60.6-0.6-0.6-0.6-0.60.2-0.8
Patch foraging total patch changes 24 sec0.71.21.5-1.21.2-1.2-0.9-1.2-1.20.2-1.2
Patch foraging total patch changes 6 sec0.20.30.9-0.40.5-0.5-0.6-0.3-0.31.0-0.3
Patch foraging time to switch 0 sec0.81.72.11.4-1.41.41.41.31.3-0.91.3
Patch foraging water rate 0 sec1.32.83.4-1.81.8-1.8-1.6-1.8-1.80.3-1.8
Patch foraging water rate 12 sec1.83.84.5-2.12.1-2.1-2.0-2.0-2.00.9-2.0
Patch foraging water rate 18 sec0.00.10.40.1-0.10.10.3-0.0-0.0-0.60.1
Patch foraging water rate 24 sec0.10.10.5-0.20.1-0.10.2-0.3-0.2-0.7-0.2
Patch foraging water rate 6 sec1.21.72.1-1.41.4-1.4-1.4-1.3-1.40.3-1.4
Seeking ratio, delayed vs. immediate footshock2.63.24.3-1.91.9-1.9-2.1-1.7-1.81.0-1.8
Distance traveled before self-admin0.10.20.3-0.40.4-0.40.0-0.5-0.5-0.6-0.4
Distance traveled after self-admin0.81.01.3-1.11.1-1.1-0.8-1.2-1.1-0.1-1.0
Extensor digitorum longus weight1.04.15.6-2.12.1-2.1-1.6-2.3-2.3-0.6-2.4
Bone: elastic displacement0.20.21.2-0.10.0-0.00.3-0.3-0.3-1.1-0.5
Bone: elastic work0.10.10.2-0.40.4-0.4-0.2-0.4-0.4-0.3-0.4
Bone: endosteal estimation0.00.10.20.4-0.30.30.20.40.40.20.3
Bone: endosteal perimeter0.20.41.00.5-0.50.50.10.80.71.00.6
Epididymis fat weight0.10.20.60.4-0.40.40.00.60.50.70.6
Delta time in closed arm before/after self-admin0.00.00.1-0.00.0-0.0-0.10.0-0.00.30.1
Delta time in open arm before/after self-admin0.20.20.3-0.40.4-0.4-0.4-0.3-0.30.3-0.5
Diff in mean of infusions in LGA sessions0.10.21.0-0.20.2-0.2-0.3-0.1-0.11.00.0
Delay discount exponential model param0.10.10.6-0.00.00.00.2-0.1-0.1-0.7-0.3
Extinction: sum of active levers before priming0.30.31.7-0.20.2-0.2-0.0-0.3-0.4-1.3-0.6
Active lever presses in extinction session 62.02.02.3-1.51.5-1.5-1.5-1.4-1.31.3-1.3
Bone: final force0.00.00.20.1-0.10.1-0.10.20.20.40.3
Bone: final moment0.00.10.3-0.10.1-0.1-0.30.00.00.60.1
Food consumed during 24 hour testing period0.81.14.8-0.80.8-0.8-1.4-0.3-0.32.2-0.2
Glucose0.20.30.8-0.50.5-0.5-0.7-0.3-0.30.9-0.3
Heart weight1.32.12.9-1.51.5-1.5-0.9-1.7-1.7-0.8-1.6
Delay discount hyperbolic model param0.10.10.4-0.10.1-0.10.1-0.2-0.2-0.6-0.4
Intermittent access intake day 1-15 change0.40.91.5-1.01.0-1.0-1.2-0.9-0.91.0-0.7
Intermittent access intake escalation0.40.81.3-1.01.0-1.0-1.1-0.9-0.90.6-0.8
Intermittent access intake escalation 20.20.20.4-0.50.5-0.5-0.7-0.4-0.40.4-0.3
Intermitt. access day 1 inactive lever presses0.52.02.5-1.61.6-1.6-1.5-1.4-1.40.8-1.2
Intermitt. access day 15 inactive lever presses0.40.81.0-0.90.9-0.9-0.8-1.0-1.0-0.3-0.9
Intermitt. access escalation Index0.10.20.70.2-0.20.20.60.10.1-0.80.3
Intermittent access day 1 total infusions0.10.10.60.2-0.20.20.30.10.1-0.80.1
Intermittent access day 15 total infusions0.20.40.4-0.60.6-0.6-0.6-0.7-0.7-0.2-0.6
Intermittent access terminal intake (last 3 days)0.00.10.1-0.20.2-0.2-0.3-0.2-0.2-0.2-0.2
Intermittent access total infusions0.00.10.4-0.00.00.00.1-0.1-0.1-0.60.0
Intermittent access day 1 locomotion0.00.00.30.1-0.10.10.1-0.00.0-0.5-0.1
Intermittent access day 15 total locomotion0.20.30.7-0.50.6-0.6-0.7-0.4-0.40.8-0.5
Intermittent access total locomotion0.00.10.3-0.10.1-0.1-0.0-0.2-0.2-0.5-0.2
Intermittent access standard deviation1.53.14.1-1.91.9-1.9-2.0-1.8-1.80.8-1.8
Left kidney weight5.224.128.5-5.35.3-5.3-5.1-5.2-5.21.5-5.0
Right kidney weight3.114.116.7-4.14.1-4.1-3.8-4.0-4.00.8-3.9
Cocaine induced anxiety0.50.71.1-0.80.8-0.8-0.5-0.8-0.8-1.0-1.0
Post-drug Anxiety1.01.12.1-1.01.0-1.0-0.5-1.0-1.0-1.4-1.0
Baseline Anxiety0.10.10.2-0.40.4-0.4-0.2-0.4-0.40.10.1
Tail length0.00.00.10.1-0.10.10.10.10.1-0.30.1
Length with tail0.20.70.9-0.90.9-0.9-0.8-0.8-0.90.5-0.7
Length without tail1.54.75.7-2.42.4-2.4-2.4-2.2-2.21.5-1.9
Times rat made contact with spout0.70.82.0-0.80.8-0.8-1.3-0.5-0.51.4-0.6
Lifetime Intake0.00.00.00.0-0.00.00.10.00.0-0.10.1
Liver weight, left0.10.20.40.3-0.30.3-0.00.50.50.60.4
Liver weight, right0.10.20.40.4-0.40.40.10.60.60.60.5
Locomotor activity0.30.42.6-0.30.3-0.4-0.6-0.00.01.60.0
Locomotor testing distance0.50.93.7-0.80.8-0.8-1.1-0.4-0.41.9-0.4
Locomotor testing rearing0.51.05.4-0.60.6-0.7-1.2-0.1-0.22.30.1
Locomotion in novel chamber3.64.55.5-2.22.2-2.2-2.3-2.0-2.01.8-2.2
Locomotion in novel chamber post-restriction0.20.41.6-0.40.4-0.4-0.1-0.5-0.5-1.3-0.7
Fecal boli incidents, locomotor time 10.10.21.1-0.20.2-0.2-0.5-0.1-0.11.10.2
Change in fecal boli incidents, locomotor task0.30.30.50.6-0.60.60.60.70.70.10.6
Time >=10cm from walls, locomotor time 11.31.42.51.2-1.21.21.20.91.0-1.60.8
Bouts of movement, locomotor time 10.70.81.31.0-0.90.91.11.01.00.30.6
Total resting periods, locomotor time 10.50.61.20.8-0.80.81.10.80.80.00.4
Rest time, locomotor task time 10.10.10.40.3-0.20.20.20.30.30.60.2
Distance moved, locomotor task time 10.30.41.70.4-0.40.40.70.30.3-1.30.5
Vertical activity count, locomotor time 10.10.30.4-0.60.6-0.6-0.5-0.5-0.5-0.0-0.4
Time >=10cm from walls, locomotor time 20.10.10.6-0.0-0.00.00.0-0.2-0.1-0.80.1
Bouts of movement, locomotor time 20.40.61.30.8-0.80.80.90.60.6-1.20.3
Total resting periods, locomotor time 20.30.61.00.8-0.80.80.90.60.6-1.00.3
Rest time, locomotor task time 20.10.10.30.4-0.30.30.10.30.30.60.4
Distance moved, locomotor task time 20.50.60.8-0.90.9-0.9-0.6-0.8-0.8-0.5-0.7
Vertical activity count, locomotor time 21.31.82.4-1.51.5-1.5-1.4-1.3-1.30.7-1.3
Light reinforcement 10.10.20.5-0.40.4-0.4-0.1-0.5-0.5-0.7-0.5
Light reinforcement 21.11.62.2-1.41.4-1.3-1.1-1.4-1.5-0.2-1.4
Bone: marrow area0.00.10.10.3-0.30.30.10.30.30.20.2
Bone: maximum diameter0.10.20.2-0.40.4-0.4-0.4-0.5-0.5-0.1-0.5
Bone: maximum force0.00.00.2-0.10.1-0.1-0.30.10.10.40.2
Bone: maximum moment0.00.10.3-0.20.2-0.2-0.4-0.1-0.10.50.0
Mean time between licks in bursts0.82.03.41.4-1.41.31.01.61.60.91.8
Mean num. licks in bursts0.40.72.4-0.60.7-0.7-1.0-0.4-0.41.6-0.4
Cd content in liver0.60.71.00.9-0.90.80.70.90.9-0.01.0
Co content in liver0.00.00.20.1-0.10.1-0.10.20.20.50.2
Cu content in liver0.60.73.70.3-0.30.2-0.40.70.71.90.8
Fe content in liver0.50.71.3-0.80.8-0.8-0.4-0.9-0.9-0.5-1.1
K content in liver0.70.73.40.3-0.30.3-0.40.70.81.80.8
Mg content in liver1.61.75.6-1.11.1-1.1-1.7-0.6-0.62.4-0.5
Mn content in liver0.30.30.40.6-0.60.60.60.50.5-0.30.6
Na content in liver0.40.50.70.7-0.70.70.40.80.80.40.8
Rb content in liver0.10.11.0-0.00.0-0.1-0.30.20.21.00.2
Se content in liver0.20.20.90.2-0.20.2-0.10.40.40.90.6
Sr content in liver0.00.00.00.0-0.00.00.1-0.0-0.0-0.2-0.0
Zn content in liver0.80.92.20.7-0.70.70.11.11.11.51.2
Bone: minimum diameter0.61.23.4-1.01.0-1.0-1.5-0.6-0.61.8-0.6
Time in familiar zone, hab. session 10.40.40.90.6-0.60.60.90.50.6-0.50.6
Time in novel zone, hab. session 10.10.10.40.2-0.20.2-0.30.30.30.60.2
Total zone transitions, hab. session 10.20.31.40.3-0.30.40.50.10.1-1.20.0
Total locomotion distance, hab. session 10.30.51.7-0.40.4-0.40.1-0.7-0.7-1.3-0.8
Locomotion velocity, hab. session 10.20.31.4-0.30.3-0.20.1-0.5-0.5-1.2-0.6
Time in familiar zone, hab. session 20.60.61.90.5-0.50.50.00.80.81.41.0
Time in novel zone, hab. session 20.20.20.8-0.10.1-0.10.2-0.3-0.3-0.9-0.6
Total zone transitions, hab. session 20.10.10.4-0.20.2-0.2-0.3-0.0-0.00.6-0.0
Total locomotion distance, hab. session 20.30.40.5-0.70.7-0.7-0.6-0.7-0.70.2-0.7
Locomotion velocity, hab. session 20.40.50.7-0.80.8-0.8-0.7-0.8-0.80.1-0.8
Novel to familiar place preference ratio1.61.72.8-1.31.3-1.3-1.7-1.0-1.01.6-1.1
Novelty place preference0.80.91.6-0.90.9-0.9-1.2-0.7-0.71.3-0.8
Time in novel zone, NPP test0.70.71.4-0.80.8-0.8-1.1-0.6-0.61.2-0.7
Total zone transitions, NPP test0.71.01.5-1.11.1-1.0-0.8-1.2-1.2-0.5-1.1
Total locomotion distance, NPP test0.91.31.7-1.21.2-1.2-0.9-1.3-1.3-0.3-1.3
Locomotion velocity, NPP test1.42.02.7-1.51.5-1.5-1.2-1.6-1.6-0.2-1.6
Intraocular pressure0.30.40.5-0.60.6-0.6-0.7-0.6-0.50.7-0.5
Delta distance traveled before/after self-admin1.31.41.9-1.21.3-1.3-1.4-1.2-1.20.7-1.1
Delta ambulatory time before/after self-admin0.81.01.2-1.11.1-1.1-1.1-1.0-1.00.7-1.0
Parametrial fat weight0.00.10.10.2-0.20.20.40.10.1-0.40.0
Pavlov. Cond. lever latency1.72.23.51.5-1.51.51.21.71.70.41.9
Pavlov. Cond. magazine entry latency0.20.20.30.6-0.60.50.40.60.6-0.00.4
Pavlov. Cond. change in total contacts0.00.00.1-0.10.1-0.1-0.1-0.2-0.2-0.3-0.2
Pavlov. Cond. index score0.30.40.8-0.60.6-0.6-0.6-0.7-0.7-0.2-0.9
Pavlov. Cond. latency score0.40.51.1-0.70.7-0.7-0.7-0.8-0.8-0.2-1.0
Pavlov. Cond. lever contacts1.31.52.7-1.31.2-1.2-1.0-1.4-1.4-0.4-1.6
Pavlov. Cond. magazine entry number0.20.30.3-0.60.6-0.6-0.5-0.6-0.60.2-0.3
Pavlov. Cond. intertrial magazine entries0.91.12.1-1.11.1-1.1-1.3-0.8-0.81.5-0.7
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-0.80.8-0.8-0.7-0.8-0.8-0.0-1.1
Pavlov. Cond. response bias0.10.10.3-0.20.2-0.2-0.1-0.3-0.3-0.5-0.6
Pavlov. Cond. lever latency0.60.84.90.3-0.30.40.9-0.2-0.2-2.2-0.2
Pavlov. Cond. magazine entry latency1.21.55.30.8-0.70.7-0.11.31.32.31.2
Pavlov. Cond. change in total contacts0.60.95.7-0.00.1-0.1-0.80.50.52.40.6
Pavlov. Cond. index score1.01.37.40.3-0.30.2-0.61.01.02.70.9
Pavlov. Cond. latency score0.91.27.00.3-0.20.2-0.60.90.92.60.8
Pavlov. Cond. lever contacts0.40.63.8-0.20.2-0.3-0.80.30.32.00.2
Pavlov. Cond. magazine entry number1.92.44.5-1.31.2-1.2-0.4-1.8-1.8-2.1-1.7
Pavlov. Cond. intertrial magazine entries0.30.42.70.3-0.30.30.7-0.1-0.1-1.60.0
Pavlov. Cond. lever-magazine prob. diff.1.11.58.30.4-0.30.2-0.61.01.02.90.9
Pavlov. Cond. response bias0.70.94.70.3-0.30.3-0.40.90.92.20.8
Time in closed arm before self-admin0.40.50.60.7-0.80.80.80.70.7-0.70.7
Time in closed arm after self-admin0.20.20.50.5-0.50.50.50.40.4-0.70.5
Time in open arm before self-admin0.10.21.1-0.20.2-0.2-0.2-0.1-0.01.1-0.0
Time in open arm after self-admin0.91.01.2-1.01.0-1.0-1.1-0.9-0.90.9-1.1
Bone: periosteal estimation0.30.60.8-0.80.8-0.8-0.9-0.8-0.80.4-0.8
Bone: periosteal perimeter0.10.20.5-0.30.4-0.4-0.6-0.2-0.20.7-0.2
Bone: post-yield work0.00.00.10.2-0.20.20.00.20.20.20.2
Progressive ratio test 1 active lever presses0.70.81.1-1.01.0-0.9-0.9-1.0-1.0-0.1-1.0
Progressive ratio test 1 breakpoint0.70.81.1-1.01.0-1.0-0.9-1.0-1.0-0.2-1.1
Progressive ratio test 1 inactive lever presses0.30.50.6-0.70.7-0.7-0.6-0.7-0.8-0.2-0.7
Progressive ratio test 2 active lever presses0.50.50.8-0.70.7-0.7-0.8-0.8-0.8-0.2-0.9
Progressive ratio test 2 breakpoint0.50.50.8-0.70.7-0.7-0.7-0.8-0.8-0.4-0.9
Progressive ratio test 2 inactive lever presses0.00.10.1-0.30.3-0.3-0.3-0.3-0.30.1-0.3
Incentive Sensitization - Responses0.00.00.00.0-0.00.0-0.1-0.1-0.1-0.1-0.1
Incentive Sensitization - Breakpoint0.00.00.1-0.10.1-0.1-0.2-0.1-0.1-0.0-0.2
Sum of active levers in priming session hrs 5-60.20.20.7-0.30.3-0.3-0.1-0.4-0.4-0.8-0.6
Progressive ratio0.20.30.4-0.70.7-0.7-0.5-0.6-0.60.4-0.2
Food seeking constrained by brief footshock2.83.54.22.0-2.02.02.11.91.9-0.81.9
Seeking ratio, punishment vs. effort2.73.94.82.2-2.22.22.12.12.1-1.01.7
Retroperitoneal fat weight0.10.30.40.6-0.60.60.60.50.6-0.20.5
Reaction time number correct0.10.21.40.1-0.20.20.5-0.1-0.1-1.20.2
Reaction time mean minus median0.30.85.40.1-0.10.0-0.60.60.52.30.5
Reaction time mean minus median AUC0.20.63.30.2-0.20.1-0.40.50.51.80.6
Reaction time num false alarms1.21.62.9-1.31.3-1.3-1.4-1.0-0.91.7-1.1
Reaction time num false alarms AUC1.92.94.1-1.71.7-1.8-2.0-1.4-1.42.0-1.5
Reaction time trials correct on left0.10.21.40.1-0.20.20.5-0.1-0.1-1.20.2
Reaction time trials on left0.10.21.00.1-0.10.20.5-0.1-0.1-1.00.2
Reaction time mean0.40.63.10.4-0.30.3-0.20.70.71.80.6
Reaction time mean AUC0.40.62.00.6-0.60.50.10.90.81.40.8
Median of all reaction times0.30.51.40.5-0.50.50.10.80.71.20.7
Reaction time omissions0.71.16.2-0.50.5-0.6-1.2-0.0-0.12.5-0.0
Reaction time false alarm rate2.33.25.6-1.71.7-1.8-2.1-1.4-1.32.4-1.5
Reaction time premature initiation rate0.10.20.80.3-0.30.2-0.10.50.40.90.5
Reaction time premature initiations0.10.20.40.4-0.40.40.30.50.40.20.7
Std. dev. reaction times0.50.96.2-0.10.1-0.2-0.80.40.32.50.4
Reaction time trials completed0.10.21.00.1-0.10.20.5-0.1-0.1-1.00.2
Reaction time trials AUC0.10.10.8-0.10.1-0.10.3-0.3-0.3-0.90.0
Run reversals in cocaine runway, females0.10.10.50.3-0.30.30.00.40.40.70.2
Run reversals in cocaine runway, males2.42.42.6-1.61.6-1.6-1.6-1.4-1.41.6-1.6
Latency to leave start box in cocaine runway0.91.01.7-1.01.0-0.9-0.8-1.1-1.1-0.6-1.3
Latency to leave start box in cocaine runway, F1.51.72.6-1.31.3-1.2-1.0-1.5-1.4-0.9-1.6
Latency to leave start box in cocaine runway, M0.10.10.60.2-0.20.20.10.20.30.80.2
Std. dev. time between licks in bursts2.12.94.21.8-1.81.81.51.91.90.12.0
Total sessions with >9 infusions0.00.00.20.1-0.10.0-0.00.10.10.50.2
Short access day 1 total inactive lever presses1.41.92.2-1.51.5-1.5-1.4-1.5-1.50.1-1.5
Short access day 10 total inactive lever presses0.10.20.3-0.50.5-0.5-0.5-0.5-0.50.3-0.3
Short access day 1 total infusions0.00.00.0-0.10.1-0.1-0.1-0.1-0.1-0.20.0
Short access day 10 total infusions0.20.20.9-0.30.3-0.3-0.0-0.4-0.4-1.0-0.3
Short access total infusions0.00.00.10.2-0.20.20.30.20.2-0.00.3
Short access day 1 locomotion1.11.31.8-1.21.2-1.2-1.3-1.1-1.11.1-1.0
Short access day 10 total locomotion0.40.70.8-0.90.9-0.9-0.8-0.9-0.90.1-0.9
Short access total locomotion0.00.00.10.2-0.20.20.30.20.2-0.20.2
One hour access (0.3 mA shock)0.10.10.10.3-0.30.30.00.30.30.20.1
Compulsive drug intake0.80.91.11.0-1.01.01.10.90.9-0.90.9
One hour access (shock baseline)0.91.41.9-1.31.3-1.3-1.4-1.2-1.20.7-1.3
Social response proportion0.20.20.40.4-0.40.30.20.50.50.50.6
Social responses1.21.62.21.3-1.31.31.11.51.40.31.4
Social time0.10.10.6-0.30.3-0.3-0.3-0.1-0.10.7-0.0
Soleus weight2.88.29.7-3.13.1-3.1-2.9-3.1-3.10.6-3.0
Bone: stiffness0.00.00.10.0-0.00.0-0.10.10.10.30.3
Tibialis anterior weight3.311.315.8-3.53.5-3.4-2.5-3.9-3.9-1.3-4.0
Time to tail flick, vehicle, before self-admin2.12.13.4-1.51.5-1.4-1.5-1.5-1.5-0.4-1.8
Time to tail flick, vehicle, after self-admin0.40.60.7-0.80.7-0.7-0.4-0.8-0.8-0.8-0.7
Time to tail flick, test, before self-admin2.72.83.9-1.61.5-1.5-1.1-1.8-1.8-1.9-2.0
Time to tail flick, test, after self-admin0.90.91.3-1.11.1-1.0-0.6-1.2-1.1-0.7-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.10.1-0.10.3-0.1-0.1-0.30.1
Delta time to tail flick, test, before/after SA0.30.31.40.3-0.30.20.30.40.41.20.8
Tibia length0.10.30.5-0.70.7-0.7-0.5-0.7-0.60.2-0.5
Ambulatory time before self-admin0.00.10.1-0.20.2-0.20.1-0.3-0.3-0.3-0.2
Ambulatory time after self-admin0.50.60.8-0.90.9-0.9-0.5-0.9-0.9-0.2-0.8
Bone: tissue strength0.70.81.10.8-0.80.80.51.01.00.71.1
Total heroin consumption0.30.30.50.6-0.60.60.70.60.6-0.20.5
Bone: trabecular number0.71.11.41.1-1.11.11.01.21.2-0.31.1
Bone: trabecular spacing1.11.41.9-1.31.3-1.3-1.0-1.4-1.4-0.2-1.3
Bone: trabecular thickness0.50.60.90.8-0.80.80.50.90.90.40.9
Bone: trabecular tissue density0.30.41.00.6-0.60.60.80.40.4-1.00.4
Water consumed over 24 hours1.01.32.5-1.11.2-1.2-1.6-0.8-0.91.4-0.8
Number of responses in last shaping day2.52.73.6-1.81.8-1.8-1.9-1.7-1.70.9-1.6