Hub : Genes

Gps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Gps1 0.06 0.05 2.5e-03 0.04 0.04 0.06 0 2.1e-03 1.9e-03 2.4e-04 1.8e-01
2 OFC gene expression Gps1 0.16 0.11 7.0e-03 0.03 -0 0 0.04 8.4e-02 3.4e-01 2.5e-01 5.0e-02
3 Adipose gene expression Gps1 0.02 0.02 7.0e-03 0.01 0.01 0 0.01 6.5e-02 1.2e-02 7.7e-02 4.3e-02
4 RMTg intron excision ratio chr10_106551445_106551636 0.15 0.1 3.0e-03 0.03 0.04 0.06 0.01 4.5e-02 2.9e-02 1.3e-02 1.3e-01
5 BLA isoform ratio XM_063268312.1 0.06 0.04 3.6e-03 0.02 0.03 0.01 0.02 2.0e-02 1.2e-02 1.1e-01 3.9e-02
6 Brain gene expression Gps1 0.05 0.03 1.6e-04 0.01 0.02 0.01 0.01 1.5e-02 7.7e-03 1.2e-02 1.4e-02
7 BLA intron excision ratio chr10_106551445_106551636 0.07 0.05 6.1e-03 0.04 0.02 0.01 0.03 2.5e-03 3.5e-02 5.9e-02 1.4e-02
8 BLA intron excision ratio chr10_106551445_106551639 0.07 0.05 6.2e-03 0.01 0.02 0.01 0.02 5.7e-02 2.4e-02 6.2e-02 1.9e-02
9 NAcc gene expression Gps1 0.03 0.02 6.8e-05 0.03 0.03 0.03 0.03 2.3e-05 2.3e-05 2.6e-05 1.6e-05
10 pVTA gene expression Gps1 0.04 0.03 5.8e-03 0.01 0.03 0.01 0.01 2.0e-02 3.6e-03 3.2e-02 1.9e-02
11 RMTg intron excision ratio chr10_106551445_106551639 0.12 0.08 9.3e-03 -0.01 -0 -0.01 -0.01 8.7e-01 3.6e-01 6.6e-01 6.8e-01
12 PL gene expression Gps1 0.03 0.03 2.9e-03 0.01 0.03 0.01 0.01 4.5e-02 8.8e-04 2.4e-02 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.6-0.5-0.3-0.40.20.5-0.70.1-0.1-0.6-0.80.1-0.8
Area under the delay curve1.31.62.41.41.51.41.0-1.51.30.8-0.81.31.2-1.21.2
BMI with tail0.41.23.5-1.9-1.3-1.4-0.81.0-1.4-0.40.4-1.2-1.10.3-0.7
BMI without tail2.26.811.5-3.4-2.8-2.8-0.92.8-3.3-1.21.2-3.2-3.31.5-3.1
Body weight2.410.416.8-4.1-3.7-3.9-2.13.5-3.5-2.82.8-3.4-3.12.5-2.7
Weight adjusted by age1.82.74.2-2.1-1.9-1.9-0.91.8-1.7-1.81.8-1.6-1.51.5-1.4
Bone surface0.20.30.6-0.5-0.6-0.5-0.30.6-0.6-0.30.3-0.5-0.60.6-0.7
Bone volume0.20.40.7-0.6-0.6-0.6-0.20.7-0.7-0.30.3-0.7-0.80.5-0.9
Breakpoint value in progressive ratio session1.11.33.9-0.6-1.1-1.2-1.41.0-0.3-2.02.0-0.3-0.11.5-0.1
Number of licking bursts0.10.10.4-0.20.1-0.00.40.1-0.50.4-0.4-0.2-0.6-0.4-0.6
Context. condit. distance diff. score0.81.02.5-0.5-0.1-0.21.40.5-1.31.0-1.0-1.0-1.6-0.7-1.5
Locomotion velocity, session 11.71.84.61.40.91.1-0.7-1.41.90.1-0.11.62.1-0.22.1
Locomotion distance, session 13.03.85.12.02.12.02.0-2.11.52.2-2.21.61.4-2.31.6
Locomotion velocity, session 23.94.66.52.52.22.30.9-2.42.51.4-1.42.42.5-1.62.5
Locomotion distance, session 20.70.92.20.70.90.81.4-0.90.31.5-1.50.40.2-1.30.5
Locomotion velocity, session 31.71.93.61.61.31.3-0.1-1.51.80.3-0.31.71.9-0.81.9
Locomotion distance, session 33.33.64.92.22.02.00.9-2.22.21.3-1.32.22.1-1.72.2
Stereotopy head waving bouts, day 30.50.51.40.70.50.6-0.3-0.81.00.0-0.00.91.2-0.21.2
Stereotopy head waving duration, day 30.40.50.90.70.60.60.2-0.80.80.4-0.40.80.9-0.51.0
Locomotion velocity, session 70.80.91.51.21.21.10.8-1.00.90.8-0.81.10.7-1.00.6
Locomotion distance, session 73.74.67.12.32.32.42.7-2.21.52.6-2.61.71.1-2.61.2
Stereotopy head waving bouts, day 70.30.30.5-0.7-0.5-0.6-0.60.6-0.5-0.50.5-0.6-0.40.5-0.4
Stereotopy head waving duration, day 70.20.30.5-0.7-0.5-0.7-0.50.6-0.6-0.50.5-0.6-0.50.5-0.4
Locomotion velocity, session 81.01.13.10.70.90.91.7-0.90.21.6-1.60.30.1-1.50.3
Locomotion distance, session 81.42.16.8-0.00.60.42.6-0.2-1.12.2-2.2-0.8-1.5-1.8-1.1
Degree of sensitization distance0.70.71.9-0.7-0.5-0.50.80.7-1.20.4-0.4-1.0-1.40.0-1.4
Degree of sensitization stereotypy0.30.40.6-0.8-0.5-0.7-0.30.6-0.7-0.30.3-0.8-0.70.3-0.6
Conditioned locomotion3.43.97.4-2.3-1.8-2.0-0.22.2-2.6-0.60.6-2.5-2.71.0-2.6
Cocaine response after cond. corrected0.20.20.40.10.0-0.1-0.6-0.10.4-0.60.60.40.50.40.5
Cocaine response after cond. not corrected0.40.40.90.70.60.5-0.1-0.70.9-0.10.10.91.0-0.20.9
Cocaine response before conditioning1.11.42.21.21.31.31.5-1.20.81.3-1.30.90.6-1.40.7
Saline control response2.33.15.0-2.1-1.7-1.8-0.62.0-2.1-1.01.0-2.1-2.21.2-2.2
Bone: connectivity density0.20.41.20.20.40.31.1-0.1-0.30.9-0.9-0.2-0.5-0.7-0.5
Bone: cortical apparent density2.43.34.92.21.92.00.7-2.12.11.2-1.22.22.0-1.52.0
Bone: cortical area5.48.314.7-3.8-3.6-3.6-2.62.9-2.7-2.72.7-2.8-2.22.5-1.8
Bone: cortical porosity2.22.36.1-1.0-1.6-1.3-2.31.0-0.0-2.52.5-0.30.41.90.3
Bone: cortical porosity2.52.76.2-1.4-1.9-1.6-2.31.3-0.4-2.52.5-0.7-0.02.1-0.2
Bone: cortical thickness5.28.714.7-3.8-3.8-3.7-3.42.8-2.3-3.13.1-2.6-1.52.8-1.1
Bone: cortical thickness1.41.62.9-1.6-1.6-1.7-1.51.2-1.0-1.41.4-1.1-0.61.2-0.3
Bone: cortical tissue density2.73.75.52.32.12.10.7-2.22.21.2-1.22.32.1-1.52.1
Condit. Reinf. active minus inactive responses2.22.53.8-2.0-1.7-1.8-0.81.8-1.9-0.90.9-1.9-1.81.2-1.7
Condit. Reinf. active-inactive response ratio0.90.91.5-1.2-1.1-1.2-0.51.1-1.1-0.70.7-1.1-1.00.7-0.9
Condit. Reinf. active responses3.94.97.5-2.7-2.3-2.4-1.12.5-2.7-1.11.1-2.7-2.61.6-2.5
Condit. Reinf. inactive responses1.11.42.3-1.4-1.2-1.1-0.61.3-1.4-0.40.4-1.5-1.40.9-1.5
Incentive salience index mean1.62.03.2-1.7-1.4-1.5-0.61.6-1.8-0.70.7-1.7-1.70.9-1.7
Condit. Reinf. lever presses0.10.20.40.00.30.20.6-0.0-0.40.6-0.6-0.1-0.5-0.5-0.5
Condit. Reinf. active minus inactive responses0.40.61.4-1.0-0.9-0.9-0.10.8-1.0-0.10.1-1.2-0.90.4-0.6
Condit. Reinf. active-inactive response ratio2.12.43.6-1.8-1.9-1.9-1.31.6-1.5-1.31.3-1.8-1.21.6-1.1
Condit. Reinf. active responses0.10.20.5-0.3-0.2-0.30.60.2-0.50.5-0.5-0.7-0.5-0.2-0.3
Condit. Reinf. inactive responses0.81.11.61.11.21.11.3-1.10.71.3-1.30.70.6-1.20.7
Condit. Reinf. lever presses0.20.30.7-0.3-0.2-0.30.80.3-0.80.3-0.3-0.7-0.9-0.2-0.7
Condit. Reinf. lever reinforcers received0.20.30.6-0.3-0.2-0.30.70.2-0.60.6-0.6-0.8-0.7-0.3-0.4
Conditioned reinforcement - actives0.10.20.90.00.20.50.9-0.40.20.3-0.30.30.1-0.60.2
Conditioned reinforcement - inactives0.30.40.9-0.7-0.6-0.6-0.50.6-0.6-1.01.0-0.7-0.50.5-0.5
Conditioned locomotion0.00.10.2-0.5-0.10.20.2-0.1-0.1-0.30.30.1-0.1-0.3-0.0
Patch foraging indifference point 0 sec0.10.10.2-0.1-0.1-0.3-0.30.4-0.3-0.20.2-0.2-0.40.3-0.5
Patch foraging indifference point AUC0.10.10.2-0.1-0.0-0.10.40.1-0.30.3-0.3-0.3-0.4-0.0-0.4
Delay disc. indifference point, 0s delay0.00.10.40.00.10.00.7-0.10.1-0.10.10.10.1-0.30.2
Delay disc. indifference point, 16s delay2.12.34.11.31.71.72.0-1.50.91.8-1.81.00.6-1.90.7
Delay disc. indifference point, 2s delay0.40.40.70.60.70.60.0-0.70.8-0.40.40.80.8-0.30.9
Delay disc. indifference point, 24s delay4.04.57.42.52.32.30.0-2.42.70.6-0.62.72.7-1.42.7
Delay disc. indifference point, 4s delay0.20.20.60.60.50.40.8-0.50.5-0.10.10.40.5-0.30.5
Delay disc. indifference point, 8s delay0.60.71.21.00.90.7-0.2-0.81.1-0.10.11.01.1-0.31.1
Indifference point function ln k0.71.21.61.11.11.20.8-1.31.11.1-1.11.21.0-1.21.2
Indifference point function log k0.71.21.61.11.11.20.8-1.31.11.1-1.11.21.0-1.21.2
Patch foraging total patch changes 0 sec0.10.10.3-0.2-0.1-0.3-0.20.4-0.4-0.10.1-0.3-0.50.2-0.5
Patch foraging total patch changes 12 sec0.20.20.5-0.2-0.5-0.4-0.50.5-0.3-0.70.7-0.3-0.20.7-0.4
Patch foraging total patch changes 18 sec0.20.31.30.30.30.31.2-0.2-0.21.0-1.0-0.1-0.4-0.6-0.3
Patch foraging total patch changes 24 sec0.50.81.2-1.0-0.8-1.0-0.41.0-1.1-0.80.8-0.9-1.00.7-1.0
Patch foraging total patch changes 6 sec0.40.71.2-0.7-0.7-0.9-0.90.9-0.7-1.11.1-0.6-0.60.9-0.7
Patch foraging time to switch 0 sec0.30.61.00.90.80.90.3-0.90.90.2-0.21.00.9-0.60.8
Patch foraging water rate 0 sec1.32.74.7-1.9-1.7-1.9-0.11.9-2.1-0.60.6-2.2-2.11.1-2.0
Patch foraging water rate 12 sec0.20.50.8-0.8-0.5-0.50.70.4-0.90.8-0.8-0.9-0.9-0.4-0.5
Patch foraging water rate 18 sec0.50.71.5-1.2-0.7-0.70.70.6-1.20.5-0.5-1.1-1.2-0.3-0.9
Patch foraging water rate 24 sec1.62.24.4-1.9-1.3-1.40.71.4-2.10.5-0.5-2.0-2.10.1-1.7
Patch foraging water rate 6 sec0.10.20.7-0.5-0.4-0.30.80.1-0.40.5-0.5-0.4-0.4-0.4-0.0
Seeking ratio, delayed vs. immediate footshock1.21.52.3-1.5-1.3-1.3-0.21.3-1.4-0.90.9-1.4-1.40.9-1.4
Distance traveled before self-admin1.01.32.1-0.8-1.1-1.4-1.31.3-0.8-1.41.4-0.8-0.61.4-0.7
Distance traveled after self-admin0.60.72.3-0.7-0.5-0.7-0.21.0-1.20.1-0.1-1.0-1.40.5-1.5
Extensor digitorum longus weight0.20.81.8-0.6-0.2-0.11.30.2-1.01.2-1.2-0.7-1.1-0.8-0.9
Bone: elastic displacement1.61.82.7-1.7-1.6-1.5-1.41.3-1.1-1.51.5-1.1-0.81.3-0.8
Bone: elastic work8.711.316.8-3.9-4.1-3.9-3.93.3-2.4-3.83.8-2.8-1.73.7-1.7
Bone: endosteal estimation0.20.41.80.20.40.51.3-0.2-0.30.9-0.9-0.1-0.5-0.7-0.5
Bone: endosteal perimeter0.61.21.6-1.2-1.1-1.1-0.71.2-1.1-1.01.0-1.0-1.11.0-1.2
Epididymis fat weight0.93.25.7-2.2-1.7-1.9-0.42.0-2.3-0.90.9-2.1-2.40.9-2.2
Delta time in closed arm before/after self-admin0.70.63.20.60.80.61.8-0.4-0.10.9-0.9-0.1-0.4-1.0-0.3
Delta time in open arm before/after self-admin0.10.10.30.10.20.2-0.4-0.20.30.1-0.10.50.3-0.10.3
Diff in mean of infusions in LGA sessions0.20.31.0-0.1-0.3-0.4-0.40.5-0.1-1.01.00.0-0.10.7-0.3
Delay discount exponential model param1.82.12.9-1.7-1.7-1.6-0.91.7-1.7-0.70.7-1.6-1.61.2-1.6
Extinction: sum of active levers before priming0.60.72.00.50.40.6-0.7-0.81.10.3-0.31.21.3-0.31.4
Active lever presses in extinction session 61.71.73.60.80.0-0.0-1.9-0.51.4-1.61.61.31.80.71.8
Bone: final force5.58.815.6-3.9-3.8-3.7-2.23.1-3.0-2.42.4-3.2-2.52.5-2.2
Bone: final moment6.610.618.1-4.3-4.1-4.0-2.63.4-3.2-2.82.8-3.4-2.62.9-2.3
Food consumed during 24 hour testing period0.30.50.9-0.6-0.5-0.6-0.30.8-0.8-0.60.6-0.8-0.90.5-1.0
Glucose5.28.121.33.11.92.0-1.6-2.64.1-0.60.63.64.60.14.4
Heart weight1.01.62.7-1.6-1.7-1.5-1.51.2-0.9-1.31.3-1.1-0.51.3-0.3
Delay discount hyperbolic model param1.61.82.6-1.6-1.6-1.5-0.71.6-1.6-0.50.5-1.5-1.51.1-1.5
Intermittent access intake day 1-15 change0.71.43.6-1.6-1.9-1.0-1.11.2-0.7-1.21.2-0.8-0.61.5-0.9
Intermittent access intake escalation0.61.23.3-1.5-1.8-1.0-1.01.1-0.6-1.01.0-0.8-0.61.4-0.9
Intermittent access intake escalation 22.42.85.5-1.8-2.3-1.6-1.51.7-0.9-2.12.1-1.0-0.72.2-1.0
Intermitt. access day 1 inactive lever presses0.83.25.6-2.2-2.0-1.7-0.81.9-2.2-0.60.6-2.4-2.31.0-2.3
Intermitt. access day 15 inactive lever presses0.40.81.7-1.2-0.8-0.60.10.8-1.20.0-0.0-1.2-1.30.1-1.3
Intermitt. access escalation Index0.40.51.4-0.8-0.4-0.30.60.6-0.90.4-0.4-0.9-1.1-0.0-1.2
Intermittent access day 1 total infusions0.00.10.3-0.5-0.4-0.3-0.10.2-0.2-0.00.0-0.1-0.20.1-0.1
Intermittent access day 15 total infusions0.60.82.4-1.6-1.5-0.8-0.40.9-0.8-0.70.7-0.8-0.70.8-0.8
Intermittent access terminal intake (last 3 days)0.81.12.3-1.5-1.5-1.0-0.31.1-0.9-0.90.9-0.9-0.91.1-1.0
Intermittent access total infusions0.30.31.1-1.1-0.9-0.5-0.10.5-0.5-0.30.3-0.5-0.50.4-0.6
Intermittent access day 1 locomotion0.00.00.1-0.2-0.10.00.2-0.10.0-0.20.20.1-0.0-0.30.1
Intermittent access day 15 total locomotion0.50.81.8-1.3-1.3-0.8-0.90.8-0.7-1.01.0-0.7-0.60.8-0.7
Intermittent access total locomotion0.30.30.8-0.9-0.8-0.5-0.50.4-0.4-0.70.7-0.4-0.40.4-0.3
Intermittent access standard deviation0.40.81.4-0.3-0.80.1-1.1-0.31.0-1.11.10.91.20.61.0
Left kidney weight0.10.61.6-0.5-0.6-0.6-1.20.20.1-1.31.3-0.10.40.60.6
Right kidney weight0.10.31.0-0.4-0.3-0.4-1.0-0.00.2-0.80.80.10.50.20.8
Cocaine induced anxiety2.33.210.3-1.2-1.6-1.7-3.21.3-0.2-2.72.7-0.30.32.20.3
Post-drug Anxiety1.61.77.30.0-0.5-0.7-2.70.30.7-1.91.90.51.11.41.1
Baseline Anxiety1.31.52.51.61.51.51.0-1.41.21.0-1.01.11.1-1.11.0
Tail length3.112.116.2-3.8-3.7-3.7-1.64.0-3.9-2.72.7-3.9-3.83.0-4.0
Length with tail1.98.113.3-2.8-3.0-3.2-2.43.0-2.3-3.63.6-2.4-2.03.0-2.0
Length without tail0.82.57.5-0.8-1.2-1.5-2.30.90.1-2.72.7-0.10.71.80.8
Times rat made contact with spout1.82.04.0-1.0-1.3-1.2-2.01.4-0.8-1.91.9-0.9-0.62.0-1.1
Lifetime Intake0.10.10.5-0.7-0.5-0.1-0.10.1-0.1-0.10.1-0.0-0.10.1-0.1
Liver weight, left0.61.01.81.20.90.90.1-1.01.3-0.10.11.31.3-0.51.3
Liver weight, right1.83.24.5-2.1-1.8-1.9-0.51.9-2.1-1.51.5-2.0-2.11.1-2.1
Locomotor activity0.61.01.61.21.11.10.7-1.11.10.5-0.51.11.1-0.81.1
Locomotor testing distance1.42.63.61.91.91.81.6-1.81.51.2-1.21.61.3-1.81.4
Locomotor testing rearing0.50.91.81.11.21.21.3-1.00.71.0-1.00.70.4-1.10.4
Locomotion in novel chamber0.30.40.90.61.00.80.6-0.70.40.7-0.70.40.3-0.90.4
Locomotion in novel chamber post-restriction2.84.56.4-2.3-2.2-2.2-1.42.5-2.3-1.41.4-2.4-2.32.0-2.5
Fecal boli incidents, locomotor time 10.30.50.90.60.70.90.6-0.80.50.6-0.60.70.4-0.90.5
Change in fecal boli incidents, locomotor task1.21.22.91.40.80.8-0.4-0.91.6-0.20.21.41.70.21.5
Time >=10cm from walls, locomotor time 10.90.92.3-0.7-0.4-0.40.60.7-1.31.0-1.0-1.1-1.5-0.2-1.5
Bouts of movement, locomotor time 11.31.52.31.41.11.30.4-1.41.50.9-0.91.41.5-0.91.5
Total resting periods, locomotor time 11.61.83.01.61.21.40.2-1.51.70.7-0.71.61.7-0.91.7
Rest time, locomotor task time 10.40.51.20.80.30.5-0.7-0.51.0-0.70.70.71.10.20.9
Distance moved, locomotor task time 10.30.40.9-0.7-0.4-0.60.60.7-0.80.2-0.2-0.7-0.90.2-0.9
Vertical activity count, locomotor time 10.40.92.0-1.1-0.7-0.80.60.9-1.30.3-0.3-1.0-1.40.1-1.3
Time >=10cm from walls, locomotor time 20.00.10.2-0.5-0.4-0.3-0.10.2-0.20.0-0.0-0.2-0.20.1-0.1
Bouts of movement, locomotor time 20.71.11.61.11.31.20.5-1.21.01.1-1.11.00.9-1.10.9
Total resting periods, locomotor time 20.50.81.40.81.11.00.8-1.00.71.2-1.20.60.4-1.20.5
Rest time, locomotor task time 20.00.00.10.30.30.30.2-0.10.2-0.00.00.10.0-0.1-0.1
Distance moved, locomotor task time 20.00.00.4-0.1-0.1-0.10.6-0.0-0.00.1-0.10.00.0-0.10.2
Vertical activity count, locomotor time 20.10.20.8-0.1-0.1-0.10.9-0.1-0.30.6-0.6-0.1-0.3-0.60.0
Light reinforcement 10.61.54.0-1.3-0.6-0.90.71.2-1.80.4-0.4-1.4-2.0-0.0-1.9
Light reinforcement 21.42.13.9-1.9-1.3-1.5-0.31.6-1.9-0.60.6-1.7-2.00.7-1.9
Bone: marrow area0.20.41.70.20.40.51.3-0.2-0.30.9-0.9-0.1-0.5-0.7-0.5
Bone: maximum diameter1.22.24.0-2.0-1.9-1.8-1.21.6-1.4-1.41.4-1.4-1.21.3-1.0
Bone: maximum force5.19.016.2-4.0-3.8-3.7-2.03.2-3.2-2.22.2-3.4-2.72.4-2.3
Bone: maximum moment6.010.518.1-4.3-4.1-4.0-2.43.4-3.3-2.62.6-3.5-2.72.8-2.4
Mean time between licks in bursts0.82.02.61.61.51.61.1-1.61.51.2-1.21.51.3-1.41.4
Mean num. licks in bursts0.50.81.8-0.5-0.8-0.7-1.30.7-0.1-1.31.3-0.40.01.3-0.2
Cd content in liver0.80.93.00.70.70.91.7-0.70.21.5-1.50.3-0.1-1.20.0
Co content in liver0.00.00.1-0.1-0.1-0.0-0.30.1-0.1-0.30.30.1-0.10.2-0.2
Cu content in liver1.31.52.8-1.2-1.4-1.2-1.61.2-0.6-1.71.7-0.8-0.41.5-0.6
Fe content in liver0.60.71.10.91.01.01.0-0.90.60.8-0.80.80.4-1.00.4
K content in liver1.21.13.3-0.9-0.4-0.60.80.9-1.50.3-0.3-1.2-1.8-0.2-1.8
Mg content in liver1.21.23.3-0.20.30.31.80.2-1.11.4-1.4-0.7-1.5-1.1-1.5
Mn content in liver0.00.00.1-0.3-0.2-0.20.00.2-0.3-0.00.0-0.3-0.20.0-0.2
Na content in liver0.20.20.50.30.50.40.7-0.2-0.10.6-0.60.1-0.3-0.7-0.3
Rb content in liver1.61.94.1-1.6-1.2-1.20.51.3-1.90.1-0.1-1.9-2.00.3-1.9
Se content in liver0.20.30.8-0.5-0.2-0.4-0.00.6-0.7-0.10.1-0.6-0.80.3-0.9
Sr content in liver0.60.51.50.30.00.0-1.2-0.10.8-0.70.70.71.00.70.8
Zn content in liver1.41.53.0-1.4-1.3-1.1-0.31.3-1.5-0.50.5-1.5-1.60.8-1.7
Bone: minimum diameter3.25.98.6-2.9-2.8-2.7-2.22.6-2.3-2.52.5-2.2-2.02.2-2.0
Time in familiar zone, hab. session 10.10.10.4-0.2-0.3-0.2-0.70.10.2-0.40.4-0.00.30.40.3
Time in novel zone, hab. session 10.10.10.40.10.10.10.6-0.0-0.10.4-0.4-0.0-0.2-0.3-0.2
Total zone transitions, hab. session 10.30.50.90.50.50.60.7-0.70.50.9-0.90.50.5-0.80.7
Total locomotion distance, hab. session 10.10.10.3-0.3-0.0-0.10.50.1-0.40.5-0.5-0.2-0.4-0.4-0.2
Locomotion velocity, hab. session 10.10.10.3-0.30.0-0.10.50.1-0.40.5-0.5-0.2-0.5-0.4-0.3
Time in familiar zone, hab. session 20.30.30.40.50.50.60.5-0.60.40.6-0.60.50.4-0.60.4
Time in novel zone, hab. session 20.00.00.10.10.10.00.3-0.10.10.2-0.2-0.00.1-0.20.2
Total zone transitions, hab. session 21.01.24.00.40.80.72.0-0.6-0.31.8-1.8-0.2-0.5-1.5-0.3
Total locomotion distance, hab. session 20.81.12.7-0.60.1-0.11.60.3-1.21.3-1.3-0.9-1.4-0.9-1.2
Locomotion velocity, hab. session 20.91.12.6-0.9-0.2-0.41.40.5-1.41.0-1.0-1.2-1.6-0.7-1.4
Novel to familiar place preference ratio3.23.54.8-2.0-2.1-2.1-2.11.9-1.3-2.12.1-1.6-1.02.2-1.1
Novelty place preference3.13.44.8-2.0-2.1-2.1-2.21.9-1.3-2.12.1-1.6-0.92.2-1.0
Time in novel zone, NPP test2.52.73.6-1.8-1.9-1.9-1.81.7-1.2-1.81.8-1.4-0.91.9-0.9
Total zone transitions, NPP test1.52.16.30.81.31.12.5-1.0-0.12.2-2.20.2-0.5-2.0-0.2
Total locomotion distance, NPP test1.11.65.00.00.80.42.2-0.2-0.91.9-1.9-0.5-1.2-1.6-0.9
Locomotion velocity, NPP test0.71.02.8-0.30.40.11.70.1-1.01.4-1.4-0.7-1.2-1.1-1.0
Intraocular pressure0.81.22.3-1.2-1.0-1.0-0.01.1-1.4-0.40.4-1.5-1.40.6-1.5
Delta distance traveled before/after self-admin0.50.61.50.50.70.81.0-0.50.21.2-1.20.3-0.1-0.9-0.2
Delta ambulatory time before/after self-admin1.31.63.21.11.41.51.6-1.20.71.8-1.80.80.3-1.50.2
Parametrial fat weight0.51.12.2-1.3-0.9-0.9-0.11.1-1.4-0.30.3-1.3-1.50.5-1.5
Pavlov. Cond. lever latency1.51.94.81.11.31.42.2-1.20.42.0-2.00.60.2-1.80.3
Pavlov. Cond. magazine entry latency2.83.66.3-1.9-2.1-2.1-2.51.9-1.2-2.32.3-1.4-0.82.4-1.0
Pavlov. Cond. change in total contacts1.11.13.6-0.6-0.8-0.9-1.90.60.1-1.71.7-0.10.41.40.3
Pavlov. Cond. index score3.44.35.8-2.2-2.2-2.3-2.42.2-1.6-2.32.3-1.7-1.32.4-1.4
Pavlov. Cond. latency score2.83.66.0-1.9-2.0-2.1-2.52.0-1.2-2.32.3-1.4-0.92.3-1.1
Pavlov. Cond. lever contacts0.91.12.1-1.0-1.0-1.1-1.51.0-0.6-1.41.4-0.6-0.41.3-0.5
Pavlov. Cond. magazine entry number3.54.49.61.92.32.23.1-2.00.92.8-2.81.30.5-2.80.7
Pavlov. Cond. intertrial magazine entries0.40.51.1-0.6-0.3-0.20.80.4-0.90.5-0.5-0.8-1.1-0.3-1.0
Pavlov. Cond. lever-magazine prob. diff.3.34.15.5-2.1-2.2-2.3-2.42.1-1.5-2.32.3-1.7-1.22.3-1.3
Pavlov. Cond. response bias2.63.26.8-1.7-1.9-1.9-2.61.7-0.8-2.32.3-1.1-0.42.3-0.6
Pavlov. Cond. lever latency0.71.02.50.90.60.7-0.7-0.91.4-0.30.31.31.6-0.01.5
Pavlov. Cond. magazine entry latency2.12.54.91.71.71.82.2-1.61.01.9-1.91.20.7-1.90.8
Pavlov. Cond. change in total contacts0.30.51.60.60.60.61.3-0.50.01.1-1.10.1-0.2-0.9-0.1
Pavlov. Cond. index score0.30.41.60.50.50.51.3-0.4-0.10.8-0.80.1-0.2-0.8-0.2
Pavlov. Cond. latency score0.40.52.10.50.60.61.4-0.4-0.11.0-1.00.0-0.3-0.9-0.3
Pavlov. Cond. lever contacts0.60.82.0-0.7-0.5-0.50.90.7-1.30.4-0.4-1.1-1.4-0.1-1.4
Pavlov. Cond. magazine entry number1.41.73.6-1.4-1.5-1.4-1.91.3-0.8-1.51.5-0.9-0.51.6-0.5
Pavlov. Cond. intertrial magazine entries1.32.03.2-1.8-1.5-1.5-0.41.5-1.7-0.70.7-1.8-1.61.0-1.5
Pavlov. Cond. lever-magazine prob. diff.0.40.61.80.70.80.71.4-0.60.21.0-1.00.3-0.0-1.00.0
Pavlov. Cond. response bias0.20.31.40.10.20.21.2-0.0-0.40.8-0.8-0.3-0.6-0.6-0.5
Time in closed arm before self-admin0.30.41.10.30.00.1-1.0-0.30.8-0.20.20.71.00.40.9
Time in closed arm after self-admin0.50.61.31.20.70.6-0.1-0.71.10.1-0.10.91.1-0.01.0
Time in open arm before self-admin0.30.31.9-0.20.20.31.4-0.1-0.50.3-0.3-0.4-0.7-0.8-0.6
Time in open arm after self-admin0.10.10.3-0.20.10.20.5-0.2-0.20.5-0.5-0.0-0.2-0.6-0.1
Bone: periosteal estimation1.42.95.2-2.3-2.1-2.0-1.01.8-1.9-1.31.3-1.9-1.61.3-1.5
Bone: periosteal perimeter3.86.69.8-2.9-3.1-2.9-2.92.6-1.8-3.03.0-2.0-1.32.8-1.3
Bone: post-yield work0.10.20.50.10.20.20.7-0.2-0.10.7-0.7-0.1-0.1-0.50.0
Progressive ratio test 1 active lever presses0.30.41.0-1.0-0.9-0.5-0.10.6-0.6-0.20.2-0.5-0.60.3-0.7
Progressive ratio test 1 breakpoint0.40.51.2-1.1-1.0-0.6-0.20.7-0.7-0.30.3-0.6-0.70.4-0.8
Progressive ratio test 1 inactive lever presses2.13.05.3-2.2-2.0-1.7-0.21.8-2.2-0.50.5-2.1-2.30.9-2.3
Progressive ratio test 2 active lever presses0.30.30.8-0.9-0.8-0.5-0.10.5-0.6-0.40.4-0.7-0.70.3-0.7
Progressive ratio test 2 breakpoint0.30.40.8-0.9-0.9-0.5-0.10.6-0.7-0.40.4-0.7-0.70.4-0.7
Progressive ratio test 2 inactive lever presses0.30.51.2-1.0-1.1-0.7-0.50.6-0.4-1.01.0-0.5-0.30.7-0.4
Incentive Sensitization - Responses0.20.30.8-0.5-0.6-0.50.00.6-0.7-0.30.3-0.9-0.70.4-0.8
Incentive Sensitization - Breakpoint0.20.30.7-0.4-0.6-0.4-0.00.5-0.7-0.40.4-0.8-0.60.4-0.7
Sum of active levers in priming session hrs 5-61.11.02.4-0.4-1.0-1.1-1.20.9-0.3-1.51.5-0.4-0.01.5-0.2
Progressive ratio0.61.01.51.11.01.00.5-1.21.20.5-0.51.21.2-0.91.2
Food seeking constrained by brief footshock0.40.51.60.30.20.2-1.3-0.20.7-0.90.90.80.80.50.6
Seeking ratio, punishment vs. effort0.10.20.4-0.6-0.3-0.3-0.40.4-0.5-0.10.1-0.4-0.60.2-0.6
Retroperitoneal fat weight2.410.316.7-4.0-2.9-3.4-1.23.6-4.0-1.71.7-3.7-4.12.0-4.0
Reaction time number correct1.53.010.40.00.70.63.2-0.3-1.22.7-2.7-0.8-1.6-2.0-1.2
Reaction time mean minus median0.10.30.90.20.20.3-0.9-0.20.7-0.50.50.70.70.40.6
Reaction time mean minus median AUC0.00.00.1-0.1-0.10.1-0.3-0.00.2-0.20.20.20.20.10.2
Reaction time num false alarms0.20.20.40.60.50.5-0.1-0.50.50.3-0.30.70.5-0.30.4
Reaction time num false alarms AUC0.40.60.90.90.90.90.4-0.90.80.7-0.70.90.7-0.70.7
Reaction time trials correct on left1.53.010.40.00.70.63.2-0.3-1.22.7-2.7-0.8-1.6-2.0-1.2
Reaction time trials on left1.63.010.70.00.70.63.3-0.3-1.22.7-2.7-0.8-1.6-2.0-1.2
Reaction time mean0.10.20.6-0.8-0.5-0.5-0.40.5-0.6-0.10.1-0.5-0.50.3-0.5
Reaction time mean AUC0.10.20.5-0.7-0.3-0.20.00.3-0.60.3-0.3-0.4-0.6-0.1-0.5
Median of all reaction times0.20.30.8-0.9-0.6-0.6-0.10.6-0.80.1-0.1-0.7-0.80.1-0.7
Reaction time omissions0.00.10.2-0.30.0-0.10.10.2-0.4-0.00.0-0.2-0.5-0.1-0.5
Reaction time false alarm rate0.70.92.10.80.50.6-1.3-0.61.3-0.70.71.31.50.41.2
Reaction time premature initiation rate0.91.32.01.41.31.40.5-1.41.40.6-0.61.21.3-0.91.2
Reaction time premature initiations1.11.94.81.21.51.52.2-1.30.51.9-1.90.50.2-1.80.3
Std. dev. reaction times0.20.40.50.50.60.70.1-0.60.70.6-0.60.70.6-0.50.6
Reaction time trials completed1.63.010.70.00.70.63.3-0.3-1.22.7-2.7-0.8-1.6-2.0-1.2
Reaction time trials AUC1.63.010.4-0.00.70.53.2-0.2-1.22.7-2.7-0.9-1.7-2.0-1.3
Run reversals in cocaine runway, females0.90.92.50.71.01.00.8-0.90.41.6-1.60.50.3-1.10.3
Run reversals in cocaine runway, males2.12.14.8-1.0-1.3-1.5-1.51.5-0.9-2.22.2-1.1-0.71.8-0.9
Latency to leave start box in cocaine runway0.40.40.90.40.70.80.9-0.70.40.8-0.80.50.3-0.80.3
Latency to leave start box in cocaine runway, F0.80.93.10.30.81.01.7-0.80.01.2-1.20.2-0.2-1.6-0.1
Latency to leave start box in cocaine runway, M0.10.10.20.2-0.0-0.1-0.50.10.3-0.00.00.20.40.50.3
Std. dev. time between licks in bursts1.21.64.3-0.60.10.02.10.2-1.31.7-1.7-1.0-1.6-1.3-1.3
Total sessions with >9 infusions0.30.40.70.30.30.70.4-0.70.80.6-0.60.80.7-0.60.7
Short access day 1 total inactive lever presses0.10.10.6-0.00.40.30.6-0.3-0.1-0.00.0-0.0-0.2-0.80.0
Short access day 10 total inactive lever presses1.43.36.4-1.7-1.5-2.0-0.62.0-2.3-1.01.0-2.5-2.31.3-2.3
Short access day 1 total infusions1.41.82.61.11.21.50.8-1.61.51.2-1.21.61.4-1.31.5
Short access day 10 total infusions1.11.42.5-1.5-1.6-1.2-1.11.2-0.9-1.11.1-0.8-0.91.2-1.1
Short access total infusions0.00.00.1-0.2-0.10.2-0.1-0.20.30.1-0.10.40.3-0.10.3
Short access day 1 locomotion0.20.31.00.1-0.10.3-0.3-0.50.80.0-0.00.90.9-0.11.0
Short access day 10 total locomotion0.30.51.50.1-0.4-0.1-0.9-0.10.7-1.21.20.60.90.70.8
Short access total locomotion0.30.40.8-0.5-0.7-0.2-0.9-0.00.5-0.90.90.50.70.50.6
One hour access (0.3 mA shock)0.30.41.3-1.1-0.9-0.40.10.5-0.70.2-0.2-0.6-0.70.2-0.7
Compulsive drug intake0.60.71.7-0.6-0.3-0.50.60.7-1.20.5-0.5-1.1-1.3-0.1-1.3
One hour access (shock baseline)0.00.10.4-0.7-0.4-0.00.30.1-0.20.0-0.0-0.1-0.2-0.0-0.3
Social response proportion0.40.40.80.70.70.70.8-0.70.40.7-0.70.40.3-0.90.4
Social responses0.30.30.70.60.70.50.6-0.60.40.6-0.60.60.2-0.90.4
Social time0.10.10.40.10.20.30.5-0.40.20.4-0.40.30.2-0.70.4
Soleus weight1.23.65.6-2.4-2.1-2.0-0.92.1-2.1-1.31.3-2.1-2.11.6-2.1
Bone: stiffness0.50.81.9-1.4-1.2-1.2-0.20.8-1.1-0.30.3-1.1-0.80.3-0.4
Tibialis anterior weight0.10.20.6-0.2-0.10.10.80.0-0.40.7-0.7-0.3-0.5-0.4-0.4
Time to tail flick, vehicle, before self-admin0.20.20.30.30.40.6-0.1-0.50.50.3-0.30.50.4-0.40.4
Time to tail flick, vehicle, after self-admin1.72.23.31.51.61.71.1-1.81.61.0-1.01.61.5-1.61.6
Time to tail flick, test, before self-admin0.10.10.20.40.30.4-0.2-0.30.4-0.10.10.10.30.00.2
Time to tail flick, test, after self-admin0.90.91.81.30.90.9-0.2-1.01.4-0.30.31.11.3-0.31.2
Delta time to tail flick, vehicle, before/after SA0.20.21.10.10.40.41.0-0.40.00.5-0.5-0.0-0.1-0.7-0.0
Delta time to tail flick, test, before/after SA0.50.51.50.70.40.3-0.3-0.61.0-0.30.31.01.1-0.01.2
Tibia length9.827.140.9-6.4-6.3-6.1-4.75.5-4.6-5.15.1-5.1-3.85.2-3.6
Ambulatory time before self-admin1.92.94.4-1.6-1.9-2.1-1.81.9-1.5-1.81.8-1.5-1.31.9-1.2
Ambulatory time after self-admin0.30.41.0-0.5-0.5-0.6-0.40.8-0.90.0-0.0-0.7-0.90.4-1.0
Bone: tissue strength1.71.73.5-1.9-1.6-1.5-0.31.3-1.7-0.60.6-1.6-1.60.6-1.4
Total heroin consumption0.70.82.30.1-0.3-0.5-1.50.10.5-1.41.40.70.80.70.9
Bone: trabecular number0.00.00.1-0.0-0.0-0.1-0.10.2-0.2-0.10.1-0.2-0.20.2-0.2
Bone: trabecular spacing0.91.24.4-0.20.30.22.10.0-1.01.3-1.3-0.6-1.3-1.3-1.1
Bone: trabecular thickness1.51.95.4-1.0-1.4-1.2-2.31.1-0.3-1.91.9-0.60.11.9-0.2
Bone: trabecular tissue density0.81.21.61.21.11.20.9-1.31.11.0-1.01.21.0-1.11.1
Water consumed over 24 hours0.20.31.00.3-0.10.0-1.00.00.5-0.90.90.40.60.60.3
Number of responses in last shaping day0.10.10.3-0.2-0.20.20.2-0.40.3-0.20.20.40.4-0.40.5