Hub : Genes

Gprc5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Gprc5b 0.41 0.11 0.0e+00 0.25 0.25 0.24 0.24 3.7e-27 7.3e-28 5.9e-26 7.6e-27
2 Adipose mRNA stability Gprc5b 0.43 0.14 0.0e+00 0.16 0.18 0.17 0.17 2.4e-17 3.5e-19 3.3e-18 1.2e-18
3 Adipose isoform ratio NM_001398762.1 0.04 0.03 8.3e-04 0.01 0.02 0.01 0.01 4.9e-02 4.2e-03 1.2e-02 1.8e-02
4 Adipose alternative TSS NM_001398762.1 0.04 0.02 9.4e-04 0.01 0.02 0.01 0.01 6.1e-02 4.5e-03 2.7e-02 2.4e-02
5 Brain gene expression Gprc5b 0.13 0.08 2.9e-07 0.08 0.06 0.07 0.07 3.9e-08 1.3e-06 3.9e-07 1.6e-07
6 Liver gene expression Gprc5b 0.06 0.03 2.9e-06 0.03 0.03 0.04 0.02 4.7e-04 9.5e-05 5.5e-05 8.7e-04
7 Brain mRNA stability Gprc5b 0.11 0.06 3.2e-05 0.06 0.05 0.04 0.05 1.4e-06 3.7e-05 2.1e-04 2.6e-05
8 LHb gene expression Gprc5b 0.37 0.16 1.1e-03 0.01 0.07 0.04 0.04 1.7e-01 7.9e-03 4.9e-02 4.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.82.71.71.41.61.6-1.6-0.50.90.6
Area under the delay curve0.20.41.2-0.0-0.8-0.0-0.0-0.00.91.10.5
BMI with tail2.48.516.33.24.03.33.4-3.0-3.30.2-0.1
BMI without tail2.614.123.94.54.94.34.4-4.3-3.31.10.5
Body weight2.19.117.54.04.23.23.2-3.5-2.50.9-0.0
Weight adjusted by age0.41.34.9-0.41.0-0.4-0.40.3-1.5-2.2-1.2
Bone surface0.71.42.91.71.51.31.3-0.9-1.20.5-0.4
Bone volume1.32.54.52.11.91.91.9-1.6-1.21.00.2
Breakpoint value in progressive ratio session0.71.32.3-1.3-0.7-1.5-1.50.80.7-1.5-0.5
Number of licking bursts1.75.011.0-2.9-3.3-2.3-2.32.81.4-0.2-0.1
Context. condit. distance diff. score0.30.30.6-0.6-0.2-0.7-0.70.50.5-0.8-0.2
Locomotion velocity, session 10.20.20.70.4-0.30.40.30.10.50.90.3
Locomotion distance, session 10.70.91.81.21.41.01.0-1.3-0.50.10.1
Locomotion velocity, session 20.20.20.70.0-0.70.10.10.10.70.90.5
Locomotion distance, session 21.41.93.71.91.61.71.7-1.4-0.80.90.1
Locomotion velocity, session 30.40.41.11.10.90.60.6-0.6-0.10.2-0.2
Locomotion distance, session 30.30.41.60.50.3-0.2-0.20.6-0.7-0.2-1.3
Stereotopy head waving bouts, day 30.30.30.8-0.7-0.6-0.6-0.60.00.9-0.20.4
Stereotopy head waving duration, day 30.10.10.3-0.2-0.1-0.1-0.2-0.40.6-0.10.6
Locomotion velocity, session 71.41.53.31.71.70.40.4-0.0-1.7-0.3-1.8
Locomotion distance, session 70.40.61.80.2-0.0-0.6-0.60.9-1.1-0.3-1.3
Stereotopy head waving bouts, day 70.30.30.60.70.70.50.5-0.80.60.20.2
Stereotopy head waving duration, day 71.31.64.11.72.01.41.4-1.5-0.7-0.0-0.1
Locomotion velocity, session 80.10.10.40.40.10.30.3-0.30.60.50.2
Locomotion distance, session 80.10.20.40.60.70.50.5-0.4-0.1-0.0-0.1
Degree of sensitization distance0.30.31.6-0.4-0.40.10.1-0.60.40.51.3
Degree of sensitization stereotypy1.21.33.01.71.61.31.3-1.2-0.40.5-0.2
Conditioned locomotion1.21.42.8-0.9-0.6-1.3-1.31.7-0.3-1.2-1.4
Cocaine response after cond. corrected0.10.20.6-0.6-0.8-0.3-0.30.40.3-0.00.2
Cocaine response after cond. not corrected0.00.00.10.30.20.20.2-0.0-0.40.1-0.2
Cocaine response before conditioning1.61.94.62.11.91.21.2-0.8-1.60.5-1.0
Saline control response0.10.10.4-0.5-0.3-0.2-0.2-0.20.4-0.10.6
Bone: connectivity density0.50.71.61.01.30.90.9-0.8-0.9-0.1-0.2
Bone: cortical apparent density0.71.02.6-1.2-1.6-1.0-1.01.01.00.30.3
Bone: cortical area2.64.27.92.82.22.42.4-2.1-1.61.50.2
Bone: cortical porosity0.80.82.81.11.70.50.5-0.8-0.9-0.7-0.6
Bone: cortical porosity0.50.51.80.71.30.10.1-0.6-0.5-1.0-0.7
Bone: cortical thickness1.72.95.42.00.92.02.0-1.8-0.32.31.2
Bone: cortical thickness1.72.16.81.2-0.21.51.4-1.30.72.61.6
Bone: cortical tissue density0.61.02.6-1.3-1.6-1.0-1.01.01.00.20.3
Condit. Reinf. active minus inactive responses0.10.10.5-0.30.1-0.4-0.4-0.10.4-0.7-0.0
Condit. Reinf. active-inactive response ratio0.30.31.5-0.20.5-0.4-0.40.1-0.1-1.2-0.6
Condit. Reinf. active responses0.10.10.2-0.5-0.2-0.1-0.1-0.10.4-0.30.4
Condit. Reinf. inactive responses0.10.20.7-0.3-0.30.30.3-0.30.10.40.8
Incentive salience index mean0.20.30.9-0.10.4-0.2-0.20.3-0.5-0.9-0.7
Condit. Reinf. lever presses0.50.71.8-0.40.2-0.5-0.50.9-1.0-1.3-1.2
Condit. Reinf. active minus inactive responses0.60.92.20.31.20.90.9-1.5-0.5-0.60.8
Condit. Reinf. active-inactive response ratio0.20.41.1-0.50.40.30.4-1.0-0.0-0.61.0
Condit. Reinf. active responses0.40.61.50.41.20.80.8-1.2-0.6-0.60.3
Condit. Reinf. inactive responses0.50.81.81.31.30.60.6-0.3-1.1-0.0-1.0
Condit. Reinf. lever presses1.01.53.31.11.81.21.3-1.6-1.1-0.30.1
Condit. Reinf. lever reinforcers received0.30.41.00.11.00.40.4-0.9-0.5-0.90.2
Conditioned reinforcement - actives0.20.83.41.0-0.00.80.7-0.60.51.90.8
Conditioned reinforcement - inactives0.41.02.7-0.8-1.6-0.1-0.10.71.11.41.0
Conditioned locomotion0.10.10.30.1-0.4-0.0-0.00.10.40.60.1
Patch foraging indifference point 0 sec0.41.13.50.80.71.11.0-1.90.50.71.3
Patch foraging indifference point AUC0.41.01.80.50.11.31.3-1.0-0.31.41.3
Delay disc. indifference point, 0s delay0.70.82.41.0-0.11.01.0-0.2-0.81.50.0
Delay disc. indifference point, 16s delay2.02.85.5-2.0-2.3-1.7-1.71.02.3-0.00.8
Delay disc. indifference point, 2s delay2.73.05.42.31.72.12.1-1.6-1.61.4-0.1
Delay disc. indifference point, 24s delay1.82.85.1-2.0-2.3-1.7-1.71.62.2-0.20.2
Delay disc. indifference point, 4s delay1.01.04.20.6-0.60.80.8-0.60.72.01.2
Delay disc. indifference point, 8s delay0.10.21.10.5-0.40.30.20.10.21.00.0
Indifference point function ln k0.10.20.30.60.30.50.5-0.5-0.10.30.0
Indifference point function log k0.10.20.30.60.30.50.5-0.5-0.10.30.0
Patch foraging total patch changes 0 sec0.51.34.30.70.81.21.2-2.10.40.61.4
Patch foraging total patch changes 12 sec0.10.20.30.10.50.40.4-0.6-0.5-0.10.3
Patch foraging total patch changes 18 sec0.20.51.4-0.0-0.40.50.5-0.60.70.91.2
Patch foraging total patch changes 24 sec0.31.12.50.90.71.21.2-1.60.20.91.2
Patch foraging total patch changes 6 sec1.52.68.6-0.4-0.80.90.9-1.72.11.62.9
Patch foraging time to switch 0 sec1.35.08.8-1.8-1.0-2.8-2.83.0-0.1-2.5-2.4
Patch foraging water rate 0 sec0.10.41.00.60.60.80.8-1.0-0.50.30.3
Patch foraging water rate 12 sec0.62.56.01.61.31.71.7-2.40.21.41.4
Patch foraging water rate 18 sec0.30.72.30.91.00.80.8-1.50.00.30.6
Patch foraging water rate 24 sec0.81.22.61.30.61.11.1-1.30.01.60.8
Patch foraging water rate 6 sec1.01.53.6-0.1-0.80.90.9-1.01.51.61.9
Seeking ratio, delayed vs. immediate footshock0.10.10.30.40.60.30.3-0.3-0.20.10.2
Distance traveled before self-admin0.20.51.80.70.10.80.8-0.30.41.30.8
Distance traveled after self-admin1.01.83.92.01.11.41.4-0.6-1.31.7-0.1
Extensor digitorum longus weight2.911.525.25.04.23.43.4-1.9-4.11.5-1.8
Bone: elastic displacement0.60.72.7-0.5-0.8-0.1-0.1-0.31.70.61.2
Bone: elastic work0.50.61.00.90.61.01.0-1.00.10.90.6
Bone: endosteal estimation1.02.35.11.82.31.21.2-0.8-2.2-0.6-1.3
Bone: endosteal perimeter0.61.54.61.21.50.70.7-0.0-2.1-0.6-1.5
Epididymis fat weight0.52.75.11.72.12.02.0-2.3-0.80.40.7
Delta time in closed arm before/after self-admin1.01.03.10.30.5-0.5-0.50.6-1.6-0.9-1.8
Delta time in open arm before/after self-admin1.21.42.60.90.81.61.6-1.6-0.50.80.9
Diff in mean of infusions in LGA sessions0.51.03.5-0.9-0.70.50.5-0.71.40.31.9
Delay discount exponential model param0.20.30.90.10.90.10.2-0.1-0.9-1.0-0.4
Extinction: sum of active levers before priming0.60.91.9-1.4-0.8-1.0-1.00.90.2-1.2-0.4
Active lever presses in extinction session 60.10.10.3-0.10.20.20.2-0.3-0.2-0.50.2
Bone: final force3.86.210.23.22.73.03.0-2.5-2.11.60.3
Bone: final moment3.55.68.93.02.62.92.9-2.6-1.81.50.5
Food consumed during 24 hour testing period0.71.52.81.30.91.71.7-1.1-1.21.00.4
Glucose0.10.10.30.0-0.30.20.1-0.20.40.50.5
Heart weight0.10.20.30.1-0.00.50.6-0.5-0.10.40.5
Delay discount hyperbolic model param0.20.20.9-0.20.5-0.2-0.10.1-0.5-0.9-0.3
Intermittent access intake day 1-15 change0.21.02.6-0.9-1.6-0.4-0.41.60.81.00.3
Intermittent access intake escalation0.21.12.9-0.9-1.7-0.4-0.41.51.01.30.5
Intermittent access intake escalation 20.71.33.3-0.9-1.8-0.6-0.61.60.81.30.3
Intermitt. access day 1 inactive lever presses0.10.62.3-1.1-1.5-0.5-0.40.80.40.50.4
Intermitt. access day 15 inactive lever presses0.00.20.40.30.00.60.60.0-0.70.3-0.1
Intermitt. access escalation Index0.10.30.6-0.20.30.70.8-0.6-0.3-0.20.6
Intermittent access day 1 total infusions0.30.82.01.11.40.80.8-1.2-0.4-0.2-0.1
Intermittent access day 15 total infusions0.10.10.50.1-0.30.30.30.10.40.70.4
Intermittent access terminal intake (last 3 days)0.10.20.40.40.20.60.6-0.40.10.60.5
Intermittent access total infusions1.11.32.11.51.21.41.4-1.3-0.41.00.5
Intermittent access day 1 locomotion0.30.51.20.60.80.80.7-1.10.20.20.5
Intermittent access day 15 total locomotion0.20.62.0-0.5-0.60.50.5-0.51.20.71.4
Intermittent access total locomotion0.60.71.50.30.51.01.0-1.20.40.41.1
Intermittent access standard deviation0.21.23.91.10.21.51.5-0.2-0.52.00.4
Left kidney weight1.07.913.73.73.13.43.4-2.9-2.31.80.3
Right kidney weight1.49.915.64.03.63.83.8-3.6-2.31.90.7
Cocaine induced anxiety0.10.41.3-1.1-0.9-0.3-0.30.90.2-0.30.2
Post-drug Anxiety0.60.71.7-1.0-1.0-0.1-0.10.21.10.51.3
Baseline Anxiety0.71.22.81.10.41.00.9-1.20.61.71.2
Tail length0.63.26.62.61.71.91.9-2.2-0.31.80.7
Length with tail0.20.93.31.81.20.50.4-1.20.20.9-0.0
Length without tail0.10.71.6-0.2-0.7-1.2-1.30.71.10.1-0.4
Times rat made contact with spout0.80.92.41.10.51.01.00.0-1.50.9-0.7
Lifetime Intake1.51.83.31.81.51.61.6-1.5-0.71.00.4
Liver weight, left0.61.13.9-0.90.4-1.2-1.10.6-0.5-2.0-0.9
Liver weight, right0.81.54.0-0.40.7-1.3-1.30.8-0.8-2.0-1.6
Locomotor activity0.10.10.4-0.10.4-0.2-0.2-0.30.0-0.6-0.3
Locomotor testing distance0.00.10.40.20.50.30.3-0.6-0.1-0.10.1
Locomotor testing rearing0.10.31.0-0.30.4-0.5-0.5-0.20.3-1.0-0.3
Locomotion in novel chamber0.60.82.10.41.30.80.8-1.4-0.1-0.50.7
Locomotion in novel chamber post-restriction0.20.51.8-1.0-0.1-0.1-0.1-0.70.9-0.41.4
Fecal boli incidents, locomotor time 10.61.64.8-0.70.4-1.3-1.31.2-0.2-2.2-1.6
Change in fecal boli incidents, locomotor task2.62.76.01.20.51.51.5-2.51.22.01.9
Time >=10cm from walls, locomotor time 10.40.50.90.90.60.90.9-0.2-0.70.60.0
Bouts of movement, locomotor time 12.33.07.3-2.7-1.9-1.8-1.81.71.1-1.50.1
Total resting periods, locomotor time 13.03.57.2-2.7-1.9-2.1-2.11.91.2-1.6-0.2
Rest time, locomotor task time 10.91.43.1-0.6-0.8-1.6-1.61.80.5-0.6-1.3
Distance moved, locomotor task time 10.51.53.40.80.91.61.6-1.8-0.30.71.2
Vertical activity count, locomotor time 10.43.15.81.30.62.42.4-1.8-0.72.11.8
Time >=10cm from walls, locomotor time 20.61.74.12.01.41.41.4-0.7-1.51.0-0.4
Bouts of movement, locomotor time 20.72.27.1-0.31.1-0.7-0.71.0-1.6-2.7-2.1
Total resting periods, locomotor time 20.52.05.90.01.3-0.5-0.50.7-1.6-2.4-2.1
Rest time, locomotor task time 20.10.10.30.60.30.20.2-0.40.50.40.1
Distance moved, locomotor task time 20.30.51.40.4-0.50.80.80.2-0.71.20.4
Vertical activity count, locomotor time 20.61.34.50.5-0.71.21.2-0.40.02.11.5
Light reinforcement 10.00.20.7-0.50.1-0.4-0.4-0.40.6-0.80.2
Light reinforcement 20.10.10.5-0.20.30.00.0-0.70.3-0.60.4
Bone: marrow area0.82.04.41.62.11.11.1-0.7-2.1-0.6-1.2
Bone: maximum diameter1.63.25.32.22.31.92.0-1.7-2.10.4-0.3
Bone: maximum force2.85.59.53.12.52.92.9-2.3-1.91.70.3
Bone: maximum moment2.64.98.12.82.42.72.7-2.4-1.61.50.5
Mean time between licks in bursts0.10.61.3-1.2-0.6-0.7-0.70.9-0.2-1.0-0.4
Mean num. licks in bursts2.36.111.03.33.22.82.8-2.7-2.01.0-0.1
Cd content in liver1.01.13.8-0.9-0.1-0.3-0.3-1.21.9-0.71.4
Co content in liver1.72.05.20.3-0.91.01.0-1.21.52.32.1
Cu content in liver1.21.42.91.00.81.41.4-1.70.11.01.2
Fe content in liver0.81.02.8-0.5-1.10.40.4-0.51.41.21.7
K content in liver0.20.20.30.10.40.60.6-0.6-0.5-0.10.4
Mg content in liver0.30.41.3-0.10.6-0.2-0.10.1-0.8-1.2-0.7
Mn content in liver0.30.31.00.50.70.40.4-0.1-1.0-0.4-0.5
Na content in liver2.73.110.51.82.21.21.3-0.2-3.2-0.5-1.6
Rb content in liver2.73.29.5-1.2-1.30.10.1-1.73.10.93.0
Se content in liver0.10.10.40.1-0.10.40.40.2-0.60.2-0.1
Sr content in liver0.50.41.30.60.90.50.5-0.2-1.1-0.4-0.5
Zn content in liver1.31.54.01.02.00.80.8-1.0-1.7-1.1-0.8
Bone: minimum diameter1.32.55.02.22.21.51.5-1.1-2.00.0-1.0
Time in familiar zone, hab. session 11.01.13.1-0.7-1.30.20.2-0.31.51.21.8
Time in novel zone, hab. session 11.51.75.11.41.8-0.3-0.40.1-1.2-1.2-2.3
Total zone transitions, hab. session 12.73.86.32.31.72.52.5-2.2-0.41.81.2
Total locomotion distance, hab. session 15.27.412.13.32.93.33.3-3.5-1.11.91.3
Locomotion velocity, hab. session 14.15.810.42.62.63.03.0-3.2-1.11.41.3
Time in familiar zone, hab. session 20.30.40.60.60.40.80.8-0.7-0.20.70.5
Time in novel zone, hab. session 20.10.10.3-0.20.1-0.3-0.30.10.2-0.5-0.2
Total zone transitions, hab. session 22.32.94.52.11.82.12.1-2.1-0.31.20.9
Total locomotion distance, hab. session 23.24.26.42.51.92.52.5-2.5-0.61.81.1
Locomotion velocity, hab. session 23.44.67.02.62.12.72.6-2.6-0.91.71.0
Novel to familiar place preference ratio0.60.82.5-1.3-1.6-0.5-0.50.60.80.40.8
Novelty place preference0.70.92.9-1.2-1.7-0.5-0.50.70.90.60.9
Time in novel zone, NPP test0.70.82.3-1.2-1.5-0.4-0.40.51.00.51.0
Total zone transitions, NPP test1.42.13.41.81.51.81.8-1.6-0.61.10.6
Total locomotion distance, NPP test1.82.54.01.71.12.02.0-1.9-0.61.61.1
Locomotion velocity, NPP test1.52.13.41.61.01.81.8-1.7-0.61.60.9
Intraocular pressure0.20.40.90.60.9-0.0-0.0-0.1-0.9-0.6-0.9
Delta distance traveled before/after self-admin0.50.61.41.01.00.40.4-0.3-1.2-0.2-0.9
Delta ambulatory time before/after self-admin0.50.92.21.31.10.60.6-0.4-1.50.2-0.9
Parametrial fat weight3.07.114.32.62.83.33.3-3.8-0.41.22.1
Pavlov. Cond. lever latency2.93.79.30.2-1.41.00.9-1.22.73.02.7
Pavlov. Cond. magazine entry latency4.05.116.21.12.90.20.2-0.1-4.0-2.8-2.7
Pavlov. Cond. change in total contacts3.94.210.90.31.4-1.0-0.91.4-3.3-2.5-3.2
Pavlov. Cond. index score3.74.712.10.32.1-0.7-0.60.8-3.5-3.2-3.0
Pavlov. Cond. latency score3.13.910.40.32.0-0.5-0.50.7-3.2-3.0-2.7
Pavlov. Cond. lever contacts3.54.210.90.52.2-0.5-0.40.7-3.3-2.9-2.9
Pavlov. Cond. magazine entry number3.34.212.1-0.5-2.00.50.5-0.83.52.82.9
Pavlov. Cond. intertrial magazine entries1.51.85.4-0.8-1.30.0-0.0-0.62.31.32.1
Pavlov. Cond. lever-magazine prob. diff.4.05.013.60.42.3-0.5-0.50.7-3.7-3.3-3.0
Pavlov. Cond. response bias4.25.213.70.52.1-0.7-0.71.1-3.7-3.1-3.4
Pavlov. Cond. lever latency0.81.12.3-1.1-1.5-1.1-1.11.41.00.1-0.1
Pavlov. Cond. magazine entry latency1.11.62.7-1.2-0.8-1.5-1.51.6-0.2-1.4-1.3
Pavlov. Cond. change in total contacts0.20.61.6-0.10.30.50.5-1.30.8-0.01.3
Pavlov. Cond. index score0.10.10.6-0.30.3-0.1-0.1-0.1-0.4-0.8-0.2
Pavlov. Cond. latency score0.10.10.5-0.20.3-0.1-0.10.0-0.5-0.7-0.4
Pavlov. Cond. lever contacts0.71.02.41.01.51.01.0-1.2-1.1-0.4-0.1
Pavlov. Cond. magazine entry number1.41.83.31.81.41.61.6-1.4-0.81.10.3
Pavlov. Cond. intertrial magazine entries1.22.55.31.92.31.71.7-1.6-1.7-0.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.9-0.50.1-0.4-0.40.2-0.4-0.9-0.4
Pavlov. Cond. response bias0.20.20.60.00.70.10.2-0.4-0.6-0.8-0.1
Time in closed arm before self-admin0.10.10.30.20.20.50.5-0.30.30.30.4
Time in closed arm after self-admin0.20.20.6-0.1-0.5-0.2-0.2-0.00.80.60.4
Time in open arm before self-admin0.81.01.8-1.1-0.8-1.3-1.31.20.2-0.8-0.4
Time in open arm after self-admin0.80.92.50.90.91.11.1-0.5-1.60.3-0.4
Bone: periosteal estimation2.14.99.03.02.92.32.3-1.8-2.60.6-0.8
Bone: periosteal perimeter1.22.45.31.92.31.41.4-1.2-2.0-0.3-0.8
Bone: post-yield work1.72.96.91.92.61.71.7-2.1-1.5-0.4-0.1
Progressive ratio test 1 active lever presses0.20.41.10.51.00.40.4-0.5-0.4-0.8-0.4
Progressive ratio test 1 breakpoint0.20.31.00.41.00.30.3-0.4-0.4-0.9-0.5
Progressive ratio test 1 inactive lever presses0.10.21.1-0.50.0-0.1-0.10.2-0.3-1.1-0.4
Progressive ratio test 2 active lever presses0.20.30.90.30.7-0.3-0.3-0.2-0.2-1.0-0.7
Progressive ratio test 2 breakpoint0.20.31.00.30.6-0.3-0.3-0.2-0.1-1.0-0.7
Progressive ratio test 2 inactive lever presses0.10.20.50.50.70.40.4-0.6-0.6-0.3-0.2
Incentive Sensitization - Responses0.10.41.10.20.4-0.5-0.60.2-0.4-1.0-1.0
Incentive Sensitization - Breakpoint0.10.30.90.30.5-0.4-0.40.0-0.4-0.9-0.9
Sum of active levers in priming session hrs 5-62.01.87.3-1.5-0.1-1.4-1.40.7-0.1-2.7-0.9
Progressive ratio0.10.31.20.40.30.50.5-1.10.00.40.9
Food seeking constrained by brief footshock0.60.71.6-1.1-1.3-0.8-0.80.51.10.20.6
Seeking ratio, punishment vs. effort0.20.41.2-0.00.2-0.4-0.40.8-0.5-0.6-1.1
Retroperitoneal fat weight1.56.517.92.23.42.72.7-4.2-0.3-0.11.8
Reaction time number correct0.20.71.4-0.9-0.3-1.2-1.20.70.4-1.1-0.6
Reaction time mean minus median0.00.20.5-0.00.00.70.7-0.20.50.30.7
Reaction time mean minus median AUC0.10.52.0-0.6-0.30.40.4-0.31.4-0.11.1
Reaction time num false alarms0.61.03.5-1.2-1.9-0.7-0.71.20.50.60.3
Reaction time num false alarms AUC0.30.71.9-1.1-1.4-0.8-0.81.20.1-0.0-0.2
Reaction time trials correct on left0.20.71.4-0.9-0.3-1.2-1.20.70.4-1.1-0.6
Reaction time trials on left0.20.71.4-0.9-0.3-1.2-1.20.60.4-1.1-0.6
Reaction time mean0.10.20.40.30.60.60.6-0.5-0.0-0.10.4
Reaction time mean AUC0.00.10.30.00.40.20.2-0.1-0.1-0.6-0.0
Median of all reaction times0.10.20.70.40.80.40.5-0.5-0.4-0.30.1
Reaction time omissions0.50.73.0-0.60.4-0.8-0.80.5-0.2-1.7-0.9
Reaction time false alarm rate0.30.41.4-0.5-1.2-0.2-0.20.9-0.20.60.0
Reaction time premature initiation rate0.71.13.21.81.20.80.8-0.3-1.20.7-0.9
Reaction time premature initiations0.20.61.81.10.9-0.0-0.00.2-0.90.0-1.3
Std. dev. reaction times0.10.30.60.30.40.80.8-0.60.40.20.7
Reaction time trials completed0.20.71.4-0.9-0.3-1.2-1.20.60.4-1.1-0.6
Reaction time trials AUC0.10.51.0-0.7-0.2-1.0-1.00.50.3-0.9-0.5
Run reversals in cocaine runway, females2.83.26.62.61.62.02.0-1.2-1.72.0-0.3
Run reversals in cocaine runway, males0.60.61.6-0.7-1.2-0.6-0.60.81.30.20.1
Latency to leave start box in cocaine runway0.40.61.7-0.00.00.50.5-1.01.00.41.3
Latency to leave start box in cocaine runway, F0.10.10.7-0.30.3-0.4-0.4-0.00.1-0.9-0.1
Latency to leave start box in cocaine runway, M1.61.53.90.2-0.21.11.0-1.41.61.22.0
Std. dev. time between licks in bursts0.30.51.8-0.60.5-0.1-0.10.2-1.2-1.4-0.5
Total sessions with >9 infusions4.75.811.73.43.42.42.4-2.7-2.00.7-0.3
Short access day 1 total inactive lever presses0.20.41.11.10.80.60.6-0.5-0.50.3-0.4
Short access day 10 total inactive lever presses0.21.63.4-1.5-1.8-1.4-1.41.70.5-0.3-0.5
Short access day 1 total infusions1.02.05.72.41.91.11.0-1.3-1.30.9-0.6
Short access day 10 total infusions1.52.55.72.32.41.51.5-1.6-1.30.1-0.6
Short access total infusions2.84.08.32.92.72.12.1-2.2-1.50.9-0.1
Short access day 1 locomotion0.50.82.11.40.70.90.9-0.6-0.31.40.2
Short access day 10 total locomotion0.52.13.71.51.91.71.8-1.5-1.5-0.2-0.2
Short access total locomotion2.84.27.52.42.42.42.4-2.7-0.81.20.9
One hour access (0.3 mA shock)0.20.20.8-0.30.40.20.2-0.50.0-0.90.2
Compulsive drug intake0.30.42.1-0.50.4-0.5-0.5-0.5-0.5-1.5-0.3
One hour access (shock baseline)0.10.30.7-0.4-0.40.30.30.00.80.50.8
Social response proportion0.20.20.6-0.50.1-0.0-0.0-0.50.5-0.80.5
Social responses0.70.92.3-1.5-0.6-0.9-0.90.50.4-1.5-0.1
Social time0.50.71.8-1.1-0.9-0.9-0.90.41.3-0.50.4
Soleus weight2.47.111.13.32.43.33.3-3.0-1.22.51.3
Bone: stiffness2.13.96.52.61.62.52.5-1.8-1.52.00.5
Tibialis anterior weight5.117.733.55.84.84.94.9-4.0-3.52.90.2
Time to tail flick, vehicle, before self-admin0.10.20.30.20.00.50.5-0.4-0.20.50.4
Time to tail flick, vehicle, after self-admin1.42.94.2-2.0-1.4-2.0-2.01.71.4-1.9-0.8
Time to tail flick, test, before self-admin0.10.10.2-0.3-0.4-0.0-0.00.5-0.10.2-0.3
Time to tail flick, test, after self-admin1.41.53.8-1.1-0.8-0.9-0.92.0-0.8-1.2-1.5
Delta time to tail flick, vehicle, before/after SA0.30.41.2-0.6-0.0-0.7-0.70.30.5-1.1-0.3
Delta time to tail flick, test, before/after SA0.10.20.60.00.30.10.10.3-0.8-0.6-0.5
Tibia length0.20.71.60.1-0.30.70.7-0.90.91.01.3
Ambulatory time before self-admin0.30.93.50.5-0.50.70.7-0.20.91.91.3
Ambulatory time after self-admin1.32.04.52.11.01.41.4-0.7-1.22.1-0.0
Bone: tissue strength0.10.10.20.40.10.30.30.1-0.10.5-0.1
Total heroin consumption0.60.83.3-0.70.3-0.9-0.90.30.3-1.8-0.5
Bone: trabecular number0.61.11.91.30.91.41.4-1.1-0.51.00.5
Bone: trabecular spacing1.52.24.9-1.5-0.4-1.7-1.71.5-0.4-2.2-1.4
Bone: trabecular thickness4.15.711.32.21.52.72.7-3.40.52.42.5
Bone: trabecular tissue density0.10.20.5-0.0-0.40.30.3-0.20.40.70.7
Water consumed over 24 hours0.61.23.7-0.5-1.3-1.0-1.01.9-0.40.2-1.3
Number of responses in last shaping day0.30.30.90.90.7-0.1-0.1-0.1-0.70.0-0.9