Gpr139

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Gpr139	0.21	0.14	9.0e-03	0.06	0.02	-0	0.01	1.5e-02	1.1e-01	4.5e-01	2.1e-01
2	PL	gene expression	Gpr139	0.07	0.04	7.6e-09	0.06	0.07	0.05	0.07	1.1e-06	4.8e-08	6.2e-06	2.1e-08
3	BLA	gene expression	Gpr139	0.18	0.08	1.2e-10	0.11	0.17	0.12	0.12	2.8e-06	2.8e-09	4.7e-07	8.3e-07
4	IC	gene expression	Gpr139	0.08	0.05	1.6e-03	0.03	0.06	0.04	0.04	2.2e-02	1.2e-03	1.3e-02	9.2e-03
5	Brain	gene expression	Gpr139	0.03	0.02	8.7e-04	0.04	0.03	0.03	0.03	2.9e-04	9.0e-04	8.8e-04	8.2e-04
6	NAcc	gene expression	Gpr139	0.02	0.02	6.7e-03	0	0	-0	0	5.9e-02	9.4e-02	8.4e-01	1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.1	2.1	3.1	-1.7	1.8	1.5	1.5	-1.3	-0.6
Area under the delay curve	0.0	0.1	0.2	0.3	-0.4	-0.3	-0.2	0.1	0.1
BMI with tail	3.3	11.7	16.0	-4.0	3.5	3.9	3.7	-3.2	-1.5
BMI without tail	3.4	18.0	24.9	-5.0	4.5	4.8	4.4	-4.0	-2.1
Body weight	2.2	9.4	15.2	-3.9	3.3	3.4	2.9	-2.6	-2.0
Weight adjusted by age	0.0	0.0	0.1	-0.3	0.1	0.3	0.2	-0.1	-0.3
Bone surface	0.8	1.6	2.8	-1.7	1.3	1.3	0.9	-0.7	-1.4
Bone volume	1.5	3.1	4.6	-2.2	2.0	1.9	1.6	-1.4	-1.3
Breakpoint value in progressive ratio session	1.0	1.7	2.2	1.5	-1.5	-1.5	-1.4	1.1	0.7
Number of licking bursts	1.7	5.1	7.0	2.6	-2.5	-2.5	-2.3	2.0	1.3
Context. condit. distance diff. score	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.6	0.5	0.4
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	0.2	0.2	0.1	0.0	-0.3
Locomotion distance, session 1	0.7	0.8	1.3	-0.9	1.0	1.1	1.0	-0.9	-0.3
Locomotion velocity, session 2	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2	0.1	-0.1
Locomotion distance, session 2	1.5	2.2	3.1	-1.6	1.5	1.8	1.5	-1.2	-1.3
Locomotion velocity, session 3	0.3	0.4	0.8	-0.7	0.5	0.6	0.4	-0.2	-0.9
Locomotion distance, session 3	0.3	0.4	1.4	-0.4	-0.4	0.1	-0.3	0.6	-1.2
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	0.9	-0.6	-0.8	-0.6	0.3	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	-0.1	-0.4	-0.2	-0.0	0.5
Locomotion velocity, session 7	1.4	1.5	6.5	-1.2	0.5	0.7	-0.0	0.6	-2.5
Locomotion distance, session 7	0.5	0.7	1.3	0.2	-0.6	-0.5	-0.9	1.1	-1.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.3	0.3	0.5	0.4	-0.3	-0.4
Stereotopy head waving duration, day 7	1.5	1.8	2.6	-1.6	1.4	1.6	1.4	-1.1	-1.0
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	-0.1	-0.1
Locomotion distance, session 8	0.2	0.2	0.3	-0.5	0.5	0.6	0.5	-0.4	-0.4
Degree of sensitization distance	0.3	0.3	1.5	0.4	0.4	-0.4	0.1	-0.4	1.2
Degree of sensitization stereotypy	1.3	1.5	2.1	-1.4	1.1	1.5	1.1	-0.7	-1.3
Conditioned locomotion	1.0	1.2	2.0	0.9	-1.2	-0.9	-1.2	1.4	-0.8
Cocaine response after cond. corrected	0.1	0.1	0.2	0.5	-0.3	-0.4	-0.3	0.1	0.3
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	0.2	0.3	0.1	0.1	-0.5
Cocaine response before conditioning	1.5	1.9	4.0	-1.9	1.1	1.4	0.8	-0.0	-2.0
Saline control response	0.1	0.2	0.9	0.4	-0.0	-0.3	-0.0	-0.0	0.9
Bone: connectivity density	0.6	0.9	1.2	-1.1	1.0	1.1	0.9	-0.7	-0.8
Bone: cortical apparent density	0.7	1.0	1.6	1.1	-1.2	-1.2	-0.9	0.8	0.8
Bone: cortical area	2.8	4.5	7.4	-2.7	2.4	2.3	2.0	-1.7	-1.5
Bone: cortical porosity	0.4	0.5	0.7	-0.9	0.7	0.8	0.5	-0.3	-0.8
Bone: cortical porosity	0.1	0.1	0.3	-0.3	0.3	0.2	0.0	0.1	-0.6
Bone: cortical thickness	1.4	2.3	3.4	-1.8	1.7	1.6	1.5	-1.4	-0.6
Bone: cortical thickness	0.6	0.7	1.0	-0.9	1.0	0.8	1.0	-1.0	-0.1
Bone: cortical tissue density	0.7	1.1	1.6	1.1	-1.3	-1.2	-1.0	0.8	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.3	0.2	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	-0.1	-0.2	-0.3	0.3	-0.1
Condit. Reinf. active responses	0.1	0.1	0.5	0.3	0.0	-0.2	0.0	-0.2	0.7
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.1	0.3	0.2	0.5	-0.8	0.7
Incentive salience index mean	0.0	0.0	0.1	0.0	0.0	-0.0	-0.2	0.3	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.3	0.2	-0.2	-0.1	-0.3	0.6	-0.5
Condit. Reinf. active minus inactive responses	1.1	1.6	2.9	-0.8	1.3	1.1	1.5	-1.7	1.0
Condit. Reinf. active-inactive response ratio	0.6	1.0	2.4	-0.0	0.7	0.4	0.9	-1.4	1.6
Condit. Reinf. active responses	0.7	1.1	1.6	-0.9	1.1	1.0	1.2	-1.3	0.5
Condit. Reinf. inactive responses	0.6	0.8	2.1	-1.2	0.7	0.9	0.3	0.1	-1.5
Condit. Reinf. lever presses	1.3	1.9	2.6	-1.4	1.6	1.6	1.5	-1.4	-0.0
Condit. Reinf. lever reinforcers received	0.4	0.6	0.9	-0.5	0.8	0.6	0.8	-1.0	0.7
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.2	0.4	0.3	0.2	-0.2	-0.2
Conditioned reinforcement - inactives	0.1	0.3	0.9	0.8	-0.3	-0.4	-0.2	-0.2	0.9
Conditioned locomotion	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	0.3	-0.0
Patch foraging indifference point 0 sec	0.4	1.0	2.2	-0.4	1.2	0.8	1.0	-1.5	0.7
Patch foraging indifference point AUC	0.6	1.4	2.3	-0.9	1.3	1.2	1.5	-1.5	0.4
Delay disc. indifference point, 0s delay	0.6	0.7	1.3	-1.1	0.6	1.0	0.7	-0.5	-0.8
Delay disc. indifference point, 16s delay	2.4	3.5	5.8	2.4	-1.9	-2.1	-1.6	1.0	1.8
Delay disc. indifference point, 2s delay	3.5	3.9	6.1	-2.5	2.0	2.2	1.9	-1.4	-1.6
Delay disc. indifference point, 24s delay	1.7	2.8	4.3	2.1	-2.0	-1.8	-1.5	1.1	1.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.5	0.4	0.4	0.5	-0.6	0.3
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.1	0.1	-0.5
Indifference point function ln k	0.1	0.2	0.4	-0.6	0.6	0.6	0.4	-0.3	-0.3
Indifference point function log k	0.1	0.2	0.4	-0.6	0.6	0.6	0.4	-0.3	-0.3
Patch foraging total patch changes 0 sec	0.5	1.5	3.1	-0.5	1.4	1.0	1.3	-1.8	0.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.9	-0.3	0.6	0.5	0.6	-0.9	0.2
Patch foraging total patch changes 18 sec	0.1	0.3	0.8	0.1	0.5	0.2	0.5	-0.9	0.6
Patch foraging total patch changes 24 sec	0.3	1.1	2.1	-0.7	1.2	0.9	1.2	-1.5	0.5
Patch foraging total patch changes 6 sec	1.1	1.9	6.0	0.4	0.9	0.2	1.1	-1.8	2.5
Patch foraging time to switch 0 sec	1.6	6.2	9.7	2.2	-2.7	-2.5	-2.9	3.1	-0.7
Patch foraging water rate 0 sec	0.2	0.7	0.9	-0.9	0.9	0.8	0.8	-1.0	0.1
Patch foraging water rate 12 sec	0.5	1.9	2.9	-1.4	1.7	1.3	1.5	-1.6	0.3
Patch foraging water rate 18 sec	0.3	0.6	0.9	-0.8	1.0	0.7	0.7	-1.0	0.3
Patch foraging water rate 24 sec	0.5	0.7	1.5	-1.2	1.0	0.7	0.7	-0.9	-0.2
Patch foraging water rate 6 sec	0.7	1.0	2.0	-0.2	0.9	0.5	1.0	-1.4	1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	-0.4	0.4	0.1	0.1	0.1	-0.1
Distance traveled before self-admin	0.1	0.3	0.8	-0.8	0.9	0.5	0.5	-0.3	-0.0
Distance traveled after self-admin	0.9	1.6	3.5	-1.9	1.4	1.2	0.7	-0.2	-1.5
Extensor digitorum longus weight	3.3	13.1	22.6	-4.8	3.3	3.8	2.6	-1.3	-4.6
Bone: elastic displacement	0.3	0.4	1.4	0.6	-0.2	-0.5	-0.2	-0.2	1.2
Bone: elastic work	0.5	0.6	1.0	-0.8	1.0	0.8	0.8	-0.9	-0.2
Bone: endosteal estimation	1.0	2.4	4.2	-2.0	1.5	1.7	1.2	-0.8	-1.7
Bone: endosteal perimeter	0.5	1.3	2.6	-1.5	0.9	1.2	0.6	-0.3	-1.6
Epididymis fat weight	0.8	4.0	5.2	-2.1	2.3	2.2	2.3	-2.2	0.0
Delta time in closed arm before/after self-admin	0.7	0.6	1.9	-0.1	-0.9	-0.1	-0.6	0.9	-1.4
Delta time in open arm before/after self-admin	2.4	2.8	4.8	-1.2	1.8	1.8	2.0	-2.2	0.0
Diff in mean of infusions in LGA sessions	0.8	1.5	3.9	0.4	0.6	0.4	1.1	-1.7	2.0
Delay discount exponential model param	0.1	0.1	0.3	-0.3	0.5	0.4	0.4	-0.3	-0.1
Extinction: sum of active levers before priming	0.4	0.5	1.1	1.0	-0.8	-0.7	-0.5	0.2	0.9
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.1	0.4	0.3	0.4	-0.6	0.4
Bone: final force	4.8	7.9	11.1	-3.3	3.1	3.2	2.8	-2.4	-1.6
Bone: final moment	4.5	7.2	9.8	-3.1	3.0	3.0	2.7	-2.5	-1.3
Food consumed during 24 hour testing period	1.3	2.6	3.5	-1.7	1.7	1.9	1.7	-1.7	-0.8
Glucose	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	-0.3	0.3
Heart weight	0.2	0.4	1.0	-0.3	0.4	0.6	0.8	-1.0	0.3
Delay discount hyperbolic model param	0.0	0.0	0.0	0.0	0.2	0.1	0.0	0.0	0.1
Intermittent access intake day 1-15 change	0.1	0.4	1.0	0.7	-1.0	-0.6	-0.5	0.5	0.5
Intermittent access intake escalation	0.1	0.5	1.1	0.8	-1.0	-0.7	-0.6	0.6	0.6
Intermittent access intake escalation 2	0.5	0.8	1.7	0.9	-1.3	-0.9	-0.7	0.8	0.5
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.9	0.9	-0.3	-0.5	-0.2	-0.1	0.9
Intermitt. access day 15 inactive lever presses	0.1	0.6	1.1	-0.3	0.5	1.0	0.9	-1.0	-0.5
Intermitt. access escalation Index	0.4	1.4	2.8	-0.9	0.9	1.2	1.5	-1.7	0.6
Intermittent access day 1 total infusions	0.3	1.0	2.3	-1.0	1.5	0.9	0.8	-0.9	-0.6
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.0	0.3	0.2	0.2	-0.3	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.5	-0.4	0.7	0.6	0.6	-0.7	0.0
Intermittent access total infusions	1.3	1.6	2.4	-1.2	1.5	1.4	1.3	-1.3	-0.6
Intermittent access day 1 locomotion	0.4	0.8	2.0	-0.8	1.4	0.7	0.8	-1.0	0.1
Intermittent access day 15 total locomotion	0.2	0.7	1.5	0.2	0.7	0.4	0.8	-1.2	1.2
Intermittent access total locomotion	1.2	1.4	2.7	-0.6	1.5	1.1	1.3	-1.6	0.6
Intermittent access standard deviation	0.3	1.6	2.4	-1.1	1.1	1.5	1.5	-1.3	-0.8
Left kidney weight	1.3	10.6	14.7	-3.8	3.8	3.5	3.1	-2.9	-2.1
Right kidney weight	1.8	12.3	15.6	-3.9	4.0	3.9	3.6	-3.4	-1.8
Cocaine induced anxiety	0.1	0.1	0.6	0.3	-0.0	-0.1	0.2	-0.4	0.8
Post-drug Anxiety	0.5	0.5	2.3	0.6	0.1	-0.3	0.2	-0.6	1.5
Baseline Anxiety	0.1	0.2	0.3	-0.5	0.6	0.4	0.5	-0.5	0.1
Tail length	0.4	2.3	4.0	-2.0	1.6	1.5	1.3	-1.2	-1.2
Length with tail	0.1	0.4	1.3	-0.7	0.4	-0.0	-0.4	0.4	-1.1
Length without tail	0.4	2.2	3.5	1.3	-1.3	-1.7	-1.9	1.9	-0.2
Times rat made contact with spout	1.2	1.4	2.7	-1.3	0.9	1.4	0.9	-0.5	-1.6
Lifetime Intake	1.6	2.0	2.9	-1.5	1.7	1.5	1.4	-1.4	-0.9
Liver weight, left	0.4	0.7	1.1	0.6	-0.8	-1.0	-1.0	0.9	0.7
Liver weight, right	0.7	1.2	2.3	0.5	-1.2	-1.1	-1.4	1.5	-0.4
Locomotor activity	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.1	0.4
Locomotor testing distance	0.1	0.2	0.3	-0.4	0.2	0.4	0.4	-0.6	0.3
Locomotor testing rearing	0.0	0.1	0.2	0.2	-0.3	-0.5	-0.4	0.2	0.5
Locomotion in novel chamber	0.7	1.0	1.6	-0.9	1.0	0.8	1.2	-1.3	0.6
Locomotion in novel chamber post-restriction	0.3	0.8	4.2	0.5	0.1	-0.5	0.2	-0.5	2.0
Fecal boli incidents, locomotor time 1	0.4	1.1	2.5	0.6	-1.0	-1.0	-1.3	1.6	-0.2
Change in fecal boli incidents, locomotor task	1.2	1.3	2.3	-0.7	1.4	0.9	1.3	-1.5	0.7
Time >=10cm from walls, locomotor time 1	0.5	0.7	1.1	-0.9	0.6	1.1	0.8	-0.6	-0.8
Bouts of movement, locomotor time 1	1.9	2.4	4.8	2.2	-1.4	-1.7	-1.3	0.8	1.6
Total resting periods, locomotor time 1	2.9	3.3	5.5	2.3	-1.9	-2.0	-1.7	1.3	1.5
Rest time, locomotor task time 1	1.9	3.1	5.9	1.1	-1.8	-1.8	-2.2	2.4	-0.7
Distance moved, locomotor task time 1	1.0	2.8	5.0	-1.1	1.8	1.7	2.0	-2.2	0.8
Vertical activity count, locomotor time 1	0.7	4.7	7.5	-1.7	2.2	2.4	2.6	-2.7	0.3
Time >=10cm from walls, locomotor time 2	0.6	1.8	3.2	-1.6	1.1	1.5	0.9	-0.5	-1.8
Bouts of movement, locomotor time 2	0.1	0.2	0.7	-0.5	-0.2	0.2	-0.2	0.4	-0.8
Total resting periods, locomotor time 2	0.1	0.3	0.9	-0.7	-0.1	0.3	-0.1	0.4	-0.9
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.2	0.3	-0.2
Distance moved, locomotor task time 2	0.4	0.5	0.7	-0.6	0.7	0.8	0.8	-0.8	-0.3
Vertical activity count, locomotor time 2	0.4	0.9	1.8	-0.6	1.0	1.0	1.2	-1.3	0.5
Light reinforcement 1	0.0	0.2	0.5	0.6	-0.2	-0.3	-0.1	-0.2	0.7
Light reinforcement 2	0.1	0.1	0.4	0.2	0.4	0.1	0.3	-0.5	0.6
Bone: marrow area	0.9	2.1	3.6	-1.9	1.5	1.6	1.1	-0.8	-1.6
Bone: maximum diameter	1.9	3.8	6.1	-2.5	2.1	2.2	1.8	-1.5	-1.3
Bone: maximum force	3.5	6.9	10.2	-3.2	2.9	3.0	2.5	-2.2	-1.6
Bone: maximum moment	3.2	6.1	8.7	-2.9	2.8	2.8	2.4	-2.2	-1.2
Mean time between licks in bursts	0.0	0.3	0.5	0.7	-0.5	-0.4	-0.3	0.2	0.7
Mean num. licks in bursts	2.7	7.4	10.2	-3.2	2.9	3.1	2.7	-2.2	-2.0
Cd content in liver	0.9	1.1	4.7	0.9	-0.2	-0.5	0.1	-0.7	2.2
Co content in liver	0.5	0.6	1.3	-0.1	0.7	0.4	0.8	-1.0	1.2
Cu content in liver	1.4	1.6	2.5	-1.1	1.4	1.3	1.5	-1.6	0.3
Fe content in liver	0.4	0.5	1.7	0.4	0.4	0.1	0.5	-0.9	1.3
K content in liver	0.5	0.5	0.8	-0.5	0.8	0.7	0.9	-0.9	0.5
Mg content in liver	0.0	0.0	0.1	-0.1	0.0	0.2	0.1	-0.0	-0.1
Mn content in liver	0.2	0.3	0.6	-0.8	0.4	0.7	0.5	-0.2	-0.4
Na content in liver	2.7	3.0	5.3	-2.3	1.6	2.0	1.3	-0.6	-2.1
Rb content in liver	2.0	2.3	9.1	1.4	-0.1	-0.5	0.5	-1.4	3.0
Se content in liver	0.2	0.2	0.4	-0.5	0.4	0.6	0.6	-0.4	-0.2
Sr content in liver	0.5	0.4	0.8	-0.9	0.7	0.8	0.6	-0.2	-0.5
Zn content in liver	1.0	1.2	1.8	-1.3	1.2	1.3	1.1	-0.8	-0.6
Bone: minimum diameter	1.5	2.8	5.1	-2.3	1.7	1.8	1.3	-0.9	-1.8
Time in familiar zone, hab. session 1	0.6	0.7	3.0	0.6	0.0	-0.2	0.4	-0.8	1.7
Time in novel zone, hab. session 1	1.3	1.5	5.7	-0.7	-0.3	-0.0	-0.9	1.4	-2.4
Total zone transitions, hab. session 1	3.2	4.5	5.7	-2.3	2.4	2.4	2.3	-2.2	-0.5
Total locomotion distance, hab. session 1	6.0	8.5	11.3	-3.2	3.4	3.2	3.1	-2.9	-0.7
Locomotion velocity, hab. session 1	5.2	7.4	9.4	-2.8	3.1	3.0	3.0	-3.0	-0.1
Time in familiar zone, hab. session 2	0.4	0.5	0.7	-0.7	0.8	0.8	0.9	-0.7	0.1
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.1	0.2
Total zone transitions, hab. session 2	2.5	3.2	4.2	-1.9	2.0	2.1	2.0	-1.8	-0.4
Total locomotion distance, hab. session 2	3.3	4.3	5.9	-2.3	2.4	2.3	2.2	-2.1	-0.5
Locomotion velocity, hab. session 2	3.8	5.1	6.6	-2.5	2.6	2.6	2.4	-2.2	-0.6
Novel to familiar place preference ratio	0.5	0.7	2.1	0.9	-0.7	-0.7	-0.3	0.0	1.4
Novelty place preference	0.5	0.6	1.5	0.9	-0.8	-0.7	-0.4	0.1	1.2
Time in novel zone, NPP test	0.5	0.6	2.3	0.9	-0.6	-0.6	-0.2	-0.1	1.5
Total zone transitions, NPP test	1.7	2.5	3.5	-1.7	1.7	1.9	1.7	-1.5	-0.7
Total locomotion distance, NPP test	2.0	2.8	3.5	-1.7	1.9	1.9	1.9	-1.8	-0.1
Locomotion velocity, NPP test	1.6	2.3	3.1	-1.5	1.7	1.7	1.7	-1.6	-0.5
Intraocular pressure	0.1	0.2	0.9	-0.3	-0.3	0.1	-0.1	0.3	-0.9
Delta distance traveled before/after self-admin	0.4	0.5	1.7	-0.7	0.4	0.6	0.2	0.1	-1.3
Delta ambulatory time before/after self-admin	0.4	0.8	2.6	-0.9	0.6	0.8	0.3	0.0	-1.6
Parametrial fat weight	4.4	10.3	15.3	-2.8	3.9	3.4	3.7	-3.7	-0.1
Pavlov. Cond. lever latency	0.5	0.6	2.0	0.2	0.4	0.0	0.6	-1.1	1.4
Pavlov. Cond. magazine entry latency	1.1	1.5	3.7	-1.5	0.9	1.3	0.6	0.1	-1.9
Pavlov. Cond. change in total contacts	1.3	1.4	4.1	-0.5	-0.7	-0.1	-0.9	1.6	-2.0
Pavlov. Cond. index score	0.6	0.8	3.0	-0.7	-0.1	0.4	-0.3	0.9	-1.7
Pavlov. Cond. latency score	0.5	0.6	2.3	-0.7	0.1	0.5	-0.1	0.7	-1.5
Pavlov. Cond. lever contacts	0.7	0.9	3.6	-0.8	0.1	0.5	-0.2	0.8	-1.9
Pavlov. Cond. magazine entry number	0.7	0.9	3.6	0.8	-0.0	-0.4	0.3	-0.9	1.9
Pavlov. Cond. intertrial magazine entries	0.8	1.0	4.0	0.9	-0.2	-0.7	-0.0	-0.7	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	3.1	-0.9	0.1	0.6	-0.1	0.8	-1.8
Pavlov. Cond. response bias	1.0	1.3	5.1	-0.8	-0.2	0.3	-0.6	1.3	-2.3
Pavlov. Cond. lever latency	1.1	1.5	2.2	1.3	-1.5	-1.4	-1.3	1.2	0.1
Pavlov. Cond. magazine entry latency	1.1	1.6	2.6	1.2	-1.2	-1.3	-1.5	1.6	-0.0
Pavlov. Cond. change in total contacts	0.4	1.0	2.8	-0.1	0.9	0.4	0.9	-1.2	1.7
Pavlov. Cond. index score	0.0	0.1	0.2	0.0	0.3	0.1	0.2	-0.1	0.5
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.2	0.1	0.1	0.1	0.2
Pavlov. Cond. lever contacts	0.9	1.3	1.9	-1.2	1.4	1.3	1.2	-1.1	-0.1
Pavlov. Cond. magazine entry number	1.6	2.1	3.0	-1.7	1.4	1.6	1.4	-1.4	-1.1
Pavlov. Cond. intertrial magazine entries	1.4	3.1	4.1	-2.0	1.7	2.0	1.8	-1.6	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.2	0.1	-0.1	-0.1	0.2	0.4
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.3	0.6	0.4	0.4	-0.4	0.5
Time in closed arm before self-admin	0.1	0.2	0.3	-0.4	0.5	0.5	0.5	-0.5	0.1
Time in closed arm after self-admin	0.3	0.3	0.5	0.5	-0.7	-0.6	-0.5	0.5	0.4
Time in open arm before self-admin	1.2	1.5	2.2	1.1	-1.3	-1.5	-1.4	1.3	0.5
Time in open arm after self-admin	1.6	1.8	2.4	-1.5	1.3	1.5	1.3	-1.2	-1.1
Bone: periosteal estimation	2.4	5.8	9.6	-3.1	2.6	2.7	2.0	-1.6	-2.2
Bone: periosteal perimeter	1.3	2.6	4.1	-2.0	1.7	1.8	1.4	-1.1	-1.4
Bone: post-yield work	1.9	3.3	4.5	-2.0	2.1	2.1	1.9	-1.7	-0.6
Progressive ratio test 1 active lever presses	0.3	0.5	1.0	-0.9	1.0	0.7	0.5	-0.7	-0.5
Progressive ratio test 1 breakpoint	0.2	0.4	0.8	-0.8	0.9	0.6	0.4	-0.6	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.1	0.5	0.4	0.3	-0.5	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.1	0.1	-0.1	-0.4	0.4	-0.5
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.1	0.0	-0.2	-0.4	0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.6	-0.5	0.8	0.6	0.4	-0.4	-0.4
Incentive Sensitization - Responses	0.2	0.5	1.2	0.1	-0.6	-0.3	-0.7	1.1	-0.8
Incentive Sensitization - Breakpoint	0.1	0.3	0.9	-0.0	-0.5	-0.2	-0.6	0.9	-0.7
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.5	1.2	-0.8	-1.0	-0.8	0.6	0.7
Progressive ratio	0.1	0.3	1.3	-0.1	0.4	0.1	0.3	-0.4	1.1
Food seeking constrained by brief footshock	0.7	0.9	1.5	1.1	-0.6	-1.1	-0.8	0.5	1.2
Seeking ratio, punishment vs. effort	0.2	0.4	1.9	-0.2	-0.2	-0.0	-0.4	0.5	-1.4
Retroperitoneal fat weight	1.7	7.5	11.4	-2.5	3.1	2.7	3.2	-3.4	0.6
Reaction time number correct	0.3	1.1	1.6	1.1	-1.1	-1.3	-1.2	0.9	0.2
Reaction time mean minus median	0.1	0.6	0.9	-0.4	0.9	0.8	1.0	-0.9	0.6
Reaction time mean minus median AUC	0.1	0.6	1.5	0.2	0.6	0.4	0.8	-1.0	1.2
Reaction time num false alarms	0.4	0.6	0.9	0.9	-1.0	-0.9	-0.7	0.2	0.7
Reaction time num false alarms AUC	0.2	0.5	1.0	0.8	-1.0	-0.8	-0.7	0.3	0.3
Reaction time trials correct on left	0.3	1.1	1.6	1.1	-1.1	-1.3	-1.2	0.9	0.2
Reaction time trials on left	0.3	1.0	1.6	1.1	-1.1	-1.3	-1.2	0.9	0.2
Reaction time mean	0.2	0.4	0.6	-0.5	0.7	0.7	0.8	-0.7	0.2
Reaction time mean AUC	0.0	0.1	0.1	-0.1	0.3	0.3	0.4	-0.2	0.1
Median of all reaction times	0.2	0.2	0.4	-0.5	0.6	0.6	0.6	-0.4	-0.0
Reaction time omissions	0.1	0.2	0.3	0.6	-0.4	-0.4	-0.5	0.5	0.0
Reaction time false alarm rate	0.0	0.0	0.2	0.2	-0.5	-0.2	-0.2	-0.0	0.0
Reaction time premature initiation rate	0.7	1.1	3.3	-1.3	0.8	0.8	0.1	0.2	-1.8
Reaction time premature initiations	0.2	0.8	2.8	-0.5	-0.0	-0.1	-0.7	0.9	-1.7
Std. dev. reaction times	0.2	0.6	1.0	-0.5	0.9	0.8	1.0	-0.9	0.4
Reaction time trials completed	0.3	1.0	1.6	1.1	-1.1	-1.3	-1.2	0.9	0.2
Reaction time trials AUC	0.2	0.7	1.1	0.9	-0.9	-1.1	-1.0	0.8	0.1
Run reversals in cocaine runway, females	3.0	3.3	5.7	-2.4	2.0	2.0	1.5	-0.9	-1.7
Run reversals in cocaine runway, males	0.4	0.4	0.7	0.8	-0.8	-0.7	-0.7	0.5	0.1
Latency to leave start box in cocaine runway	0.4	0.5	1.4	-0.1	0.3	0.4	0.8	-1.2	1.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.2	0.1	0.3
Latency to leave start box in cocaine runway, M	1.3	1.2	2.9	-0.1	0.8	0.8	1.3	-1.7	1.3
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.2	0.4	0.4	0.5	-0.5	0.5
Total sessions with >9 infusions	4.5	5.6	8.5	-2.9	2.8	2.5	2.0	-1.6	-2.2
Short access day 1 total inactive lever presses	0.2	0.5	1.0	-0.7	0.6	0.8	0.4	-0.3	-1.0
Short access day 10 total inactive lever presses	0.2	1.6	2.5	1.6	-1.5	-1.3	-1.3	1.2	0.4
Short access day 1 total infusions	0.6	1.3	3.2	-1.7	0.9	0.9	0.3	-0.1	-1.8
Short access day 10 total infusions	1.6	2.7	3.7	-1.8	1.9	1.8	1.2	-1.0	-1.8
Short access total infusions	2.8	4.0	5.7	-2.4	2.2	2.2	1.7	-1.6	-1.8
Short access day 1 locomotion	0.3	0.5	1.0	-1.0	0.8	0.6	0.3	-0.1	-0.9
Short access day 10 total locomotion	1.1	4.3	5.7	-2.2	2.2	2.4	2.2	-2.1	-1.0
Short access total locomotion	3.5	5.4	7.5	-2.4	2.7	2.5	2.5	-2.4	-0.8
One hour access (0.3 mA shock)	0.3	0.4	0.8	-0.1	0.7	0.5	0.7	-0.9	0.5
Compulsive drug intake	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1	0.1	0.4
One hour access (shock baseline)	0.1	0.3	0.7	0.2	0.4	0.2	0.5	-0.8	0.7
Social response proportion	0.3	0.4	1.3	0.4	0.2	0.2	0.4	-0.8	1.1
Social responses	0.4	0.5	1.3	1.0	-0.6	-0.6	-0.3	-0.0	1.2
Social time	0.5	0.8	1.8	1.3	-0.8	-0.9	-0.7	0.3	0.9
Soleus weight	2.5	7.4	9.6	-3.0	3.0	3.1	2.9	-2.5	-1.1
Bone: stiffness	2.6	4.8	7.0	-2.6	2.4	2.5	2.2	-1.9	-1.3
Tibialis anterior weight	5.9	20.3	30.1	-5.5	4.8	5.0	4.2	-3.4	-3.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	-0.4	0.1	0.5	0.6	-0.7	0.2
Time to tail flick, vehicle, after self-admin	1.4	2.8	4.1	2.0	-2.0	-1.8	-1.7	1.4	0.8
Time to tail flick, test, before self-admin	0.0	0.1	0.2	-0.1	-0.4	0.3	0.2	-0.2	-0.1
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.8	-0.8	-0.2	-0.5	0.7	-0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.9	0.9	-0.4	-0.6	-0.5	0.4	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.1	0.4	0.3	0.2	-0.0	-0.5
Tibia length	0.2	0.5	1.1	-0.3	0.7	0.4	0.7	-1.0	1.1
Ambulatory time before self-admin	0.1	0.2	0.4	-0.5	0.7	0.1	0.2	-0.2	0.4
Ambulatory time after self-admin	0.9	1.5	3.5	-1.9	1.4	1.0	0.5	0.1	-1.5
Bone: tissue strength	0.1	0.1	0.2	-0.4	0.3	0.2	0.0	0.0	-0.4
Total heroin consumption	0.4	0.5	0.6	0.7	-0.7	-0.8	-0.7	0.6	0.6
Bone: trabecular number	0.8	1.5	2.1	-1.4	1.4	1.3	1.2	-1.1	-0.7
Bone: trabecular spacing	1.0	1.5	2.1	1.4	-1.4	-1.3	-1.3	1.3	0.3
Bone: trabecular thickness	3.7	5.2	8.1	-2.0	2.8	2.2	2.6	-2.7	0.6
Bone: trabecular tissue density	0.0	0.1	0.2	-0.1	0.2	0.2	0.3	-0.4	0.3
Water consumed over 24 hours	0.8	1.5	2.4	0.7	-1.2	-0.8	-1.3	1.6	-1.3
Number of responses in last shaping day	0.3	0.4	1.4	-0.5	0.0	-0.2	-0.5	0.8	-1.2