Gp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Gp6	0.09	0.06	6.2e-11	0.06	0.06	0.06	0.06	3.9e-10	9.9e-10	1.9e-09	5.2e-10
2	Brain	gene expression	Gp6	0.06	0.04	1.1e-05	0.05	0.06	0.05	0.06	2.3e-05	5.3e-06	1.2e-05	4.6e-06
3	Liver	gene expression	Gp6	0.02	0.02	3.4e-03	0	0.01	0.01	0.01	1.0e-01	1.2e-02	2.1e-02	2.3e-02
4	LHb	alternative TSS	XM_039097279.2	0.12	0.09	8.6e-03	0.1	0.08	0.09	0.08	2.2e-03	5.9e-03	4.4e-03	5.9e-03
5	PL	gene expression	Gp6	0.06	0.04	2.8e-05	0.04	0.04	0.06	0.04	1.4e-05	2.1e-05	1.9e-07	2.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.1	0.1	0.3	-0.3	0.3	-0.2	-0.2
Area under the delay curve	0.3	0.5	1.0	-0.7	0.6	-0.6	1.0	0.2
BMI with tail	0.4	1.5	2.0	-1.4	1.3	-1.4	1.2	0.0
BMI without tail	0.0	0.2	0.3	0.4	-0.5	0.3	-0.5	0.3
Body weight	1.1	5.0	6.6	2.5	-2.5	2.3	-2.6	1.0
Weight adjusted by age	0.2	0.5	1.0	0.7	-0.8	1.0	-0.5	0.0
Bone surface	2.5	5.0	6.6	2.5	-2.5	2.4	-2.6	0.3
Bone volume	1.8	3.7	4.8	2.2	-2.1	2.1	-2.1	0.3
Breakpoint value in progressive ratio session	0.3	0.6	1.4	-0.7	0.7	-0.7	-0.1	-1.2
Number of licking bursts	0.0	0.1	0.1	-0.3	0.3	-0.3	0.1	-0.2
Context. condit. distance diff. score	0.1	0.2	0.5	-0.3	0.4	-0.3	-0.0	-0.7
Locomotion velocity, session 1	0.4	0.5	1.3	-0.4	0.4	0.1	0.9	-1.1
Locomotion distance, session 1	1.6	2.0	3.2	1.4	-1.4	1.8	-1.5	-0.9
Locomotion velocity, session 2	0.3	0.4	0.9	-0.6	0.6	-0.2	0.6	-0.9
Locomotion distance, session 2	1.1	1.6	2.6	1.5	-1.5	1.6	-0.9	0.0
Locomotion velocity, session 3	0.0	0.1	0.1	-0.3	0.3	-0.2	0.1	-0.2
Locomotion distance, session 3	0.2	0.2	0.5	0.2	-0.3	0.5	-0.5	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.3	-0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.2	-0.1
Locomotion velocity, session 7	0.1	0.1	0.4	0.1	-0.1	0.2	-0.4	-0.7
Locomotion distance, session 7	0.1	0.1	0.2	0.0	0.1	0.1	0.3	-0.5
Stereotopy head waving bouts, day 7	0.4	0.4	1.5	0.4	-0.5	0.4	-1.2	-0.5
Stereotopy head waving duration, day 7	0.3	0.3	1.1	0.4	-0.5	0.4	-1.1	-0.3
Locomotion velocity, session 8	0.3	0.4	1.9	-0.2	0.3	-0.0	-0.2	-1.4
Locomotion distance, session 8	0.1	0.2	0.4	0.4	-0.3	0.5	-0.3	-0.7
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.1
Degree of sensitization stereotypy	0.1	0.1	0.5	0.1	-0.2	0.1	-0.7	-0.2
Conditioned locomotion	0.2	0.2	0.8	0.1	-0.1	0.2	-0.5	-0.9
Cocaine response after cond. corrected	1.2	1.8	2.3	-1.2	1.3	-1.5	1.5	1.2
Cocaine response after cond. not corrected	0.3	0.4	1.8	0.3	-0.3	0.1	0.2	1.3
Cocaine response before conditioning	5.9	7.1	9.6	3.0	-3.0	3.1	-2.8	0.1
Saline control response	0.3	0.4	1.5	-0.1	0.1	0.3	-0.6	-1.2
Bone: connectivity density	0.0	0.1	0.1	-0.2	0.3	-0.2	0.3	0.2
Bone: cortical apparent density	0.2	0.3	1.1	-0.0	0.0	0.2	1.1	0.3
Bone: cortical area	0.9	1.4	2.4	1.3	-1.3	1.2	-1.6	0.1
Bone: cortical porosity	0.6	0.6	1.3	-0.7	0.8	-0.8	-0.4	-1.1
Bone: cortical porosity	0.4	0.5	1.1	-0.2	0.3	-0.5	-1.0	-1.0
Bone: cortical thickness	0.3	0.5	0.7	-0.9	0.8	-0.7	0.4	-0.8
Bone: cortical thickness	0.1	0.1	0.2	0.2	-0.2	0.4	0.4	0.2
Bone: cortical tissue density	0.2	0.3	1.2	-0.0	0.0	0.2	1.1	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.1	-0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.9	-1.4	1.4	-1.4	1.0	-0.1
Condit. Reinf. active responses	0.2	0.3	1.0	0.3	-0.3	0.3	-1.0	-0.5
Condit. Reinf. inactive responses	2.7	3.5	5.1	2.0	-2.0	2.0	-2.3	-0.6
Incentive salience index mean	0.1	0.1	0.2	0.2	-0.2	0.3	-0.4	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.1	1.0	-1.0	1.1	-0.4	0.5
Condit. Reinf. active minus inactive responses	3.1	4.7	6.5	2.4	-2.4	2.4	-2.6	-0.3
Condit. Reinf. active-inactive response ratio	3.7	5.9	7.8	2.8	-2.8	2.6	-2.6	0.4
Condit. Reinf. active responses	3.1	4.5	7.0	2.1	-2.1	2.2	-2.7	-1.1
Condit. Reinf. inactive responses	0.4	0.6	2.2	0.1	-0.0	0.2	-0.9	-1.5
Condit. Reinf. lever presses	0.9	1.3	3.4	1.1	-1.1	0.8	-1.8	0.0
Condit. Reinf. lever reinforcers received	4.0	5.5	8.6	2.4	-2.4	2.5	-2.9	-1.1
Conditioned reinforcement - actives	0.3	1.3	5.2	0.5	-0.6	0.5	0.6	2.3
Conditioned reinforcement - inactives	0.9	2.5	3.5	1.8	-1.8	1.9	-0.5	1.5
Conditioned locomotion	0.2	0.2	0.7	0.4	-0.4	0.3	0.1	0.8
Patch foraging indifference point 0 sec	0.2	0.7	1.3	-0.8	0.9	-0.6	0.3	-1.2
Patch foraging indifference point AUC	0.3	0.7	1.1	-1.0	0.9	-1.0	0.8	-0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	0.3	0.1	0.5	-0.4
Delay disc. indifference point, 16s delay	0.3	0.4	1.0	-0.7	0.6	-1.0	0.3	-0.1
Delay disc. indifference point, 2s delay	1.2	1.4	3.8	-0.9	0.9	-0.6	1.9	1.0
Delay disc. indifference point, 24s delay	0.3	0.5	0.9	-0.8	0.7	-0.9	0.5	-0.5
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	0.2	-0.3	0.3	0.3	1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.4	0.3	-0.3	0.6	0.0
Indifference point function ln k	2.2	6.5	9.4	2.8	-2.8	3.1	-2.7	-0.3
Indifference point function log k	2.2	6.5	9.4	2.8	-2.8	3.1	-2.7	-0.3
Patch foraging total patch changes 0 sec	0.2	0.6	1.2	-0.8	0.9	-0.6	0.3	-1.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	-0.6	0.6	-0.7	0.3	-0.2
Patch foraging total patch changes 18 sec	0.3	0.6	0.9	-0.9	1.0	-0.9	0.2	-0.6
Patch foraging total patch changes 24 sec	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.1	0.6
Patch foraging total patch changes 6 sec	0.7	1.1	1.6	-1.2	1.3	-1.3	0.7	-0.6
Patch foraging time to switch 0 sec	0.9	3.3	4.7	-1.6	1.5	-2.2	1.6	2.2
Patch foraging water rate 0 sec	0.2	0.8	1.3	0.7	-0.7	1.0	-0.7	-1.1
Patch foraging water rate 12 sec	0.6	2.6	4.2	1.7	-1.6	2.0	-1.5	-1.0
Patch foraging water rate 18 sec	0.5	1.1	1.7	0.9	-0.9	1.3	-1.1	-1.0
Patch foraging water rate 24 sec	0.7	1.0	1.5	1.0	-1.0	1.2	-1.1	-0.7
Patch foraging water rate 6 sec	5.1	7.5	9.5	3.1	-3.1	3.1	-3.0	0.5
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	2.3	-0.1	0.1	0.4	-0.4	-1.5
Distance traveled before self-admin	0.8	1.7	3.2	1.1	-1.1	1.8	-1.1	-1.3
Distance traveled after self-admin	1.2	2.2	9.3	-0.8	0.8	-0.3	-0.5	-3.1
Extensor digitorum longus weight	0.3	1.1	1.3	1.1	-1.2	0.9	-1.1	0.8
Bone: elastic displacement	0.6	0.8	2.6	-0.7	0.7	-0.7	-0.2	-1.6
Bone: elastic work	0.3	0.4	0.6	0.8	-0.8	0.8	-0.5	0.2
Bone: endosteal estimation	2.5	6.2	8.3	2.9	-2.9	2.6	-2.3	1.6
Bone: endosteal perimeter	1.6	3.9	5.1	2.2	-2.2	2.1	-2.1	0.7
Epididymis fat weight	0.1	0.3	1.5	0.2	-0.2	-0.2	-0.2	1.2
Delta time in closed arm before/after self-admin	0.4	0.4	1.0	-0.3	0.3	-0.3	1.0	0.8
Delta time in open arm before/after self-admin	1.8	2.2	4.3	1.2	-1.2	1.4	-2.1	-1.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.1	0.0	0.3	0.6	0.5
Delay discount exponential model param	0.2	0.3	0.8	0.6	-0.5	0.5	-0.9	-0.3
Extinction: sum of active levers before priming	0.4	0.5	2.4	-0.3	0.3	-0.2	-0.3	-1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	0.0	0.0	-0.4	-0.3	0.1
Bone: final force	1.9	3.2	4.3	2.1	-2.1	2.0	-1.0	1.5
Bone: final moment	2.4	3.9	5.3	2.3	-2.3	2.3	-1.1	1.6
Food consumed during 24 hour testing period	1.0	2.0	2.7	1.6	-1.6	1.6	-1.3	0.5
Glucose	1.5	2.4	3.1	-1.7	1.8	-1.6	1.8	-0.8
Heart weight	1.3	2.1	2.6	1.6	-1.6	1.4	-1.6	0.8
Delay discount hyperbolic model param	0.4	0.5	1.2	0.7	-0.6	0.5	-1.1	-0.4
Intermittent access intake day 1-15 change	0.2	0.9	1.3	1.1	-1.2	1.0	-0.8	0.4
Intermittent access intake escalation	0.3	1.5	2.2	1.5	-1.5	1.3	-1.1	0.6
Intermittent access intake escalation 2	0.1	0.2	0.5	0.3	-0.3	0.5	-0.4	-0.7
Intermitt. access day 1 inactive lever presses	0.1	1.8	2.6	1.6	-1.6	1.4	-1.3	0.7
Intermitt. access day 15 inactive lever presses	0.6	3.1	4.3	2.0	-2.1	1.8	-1.9	0.5
Intermitt. access escalation Index	0.1	0.4	0.7	-0.6	0.6	-0.7	0.8	-0.2
Intermittent access day 1 total infusions	0.3	0.9	2.4	0.9	-0.9	0.8	-0.1	1.5
Intermittent access day 15 total infusions	0.7	1.6	2.9	1.4	-1.4	1.1	-0.4	1.7
Intermittent access terminal intake (last 3 days)	0.8	1.5	2.8	1.3	-1.3	1.1	-0.1	1.7
Intermittent access total infusions	1.8	2.2	4.6	1.5	-1.5	1.3	-0.2	2.1
Intermittent access day 1 locomotion	0.9	1.6	2.6	1.3	-1.4	1.2	-0.1	1.6
Intermittent access day 15 total locomotion	0.4	1.5	2.5	1.4	-1.4	1.6	-0.2	1.1
Intermittent access total locomotion	2.8	3.3	4.6	2.1	-2.1	2.1	-0.7	1.7
Intermittent access standard deviation	0.0	0.2	0.6	-0.4	0.4	-0.4	0.8	0.2
Left kidney weight	2.8	22.7	28.9	5.3	-5.4	5.2	-5.3	1.1
Right kidney weight	3.3	22.9	29.5	5.4	-5.4	5.0	-5.4	1.5
Cocaine induced anxiety	0.6	1.6	3.6	1.1	-1.1	1.2	-1.9	-1.0
Post-drug Anxiety	1.0	1.2	3.3	0.9	-0.9	0.6	-1.8	-0.8
Baseline Anxiety	0.4	0.7	1.1	-0.7	0.8	-0.9	1.0	0.5
Tail length	2.2	11.7	15.1	3.9	-3.9	3.7	-3.8	0.8
Length with tail	2.9	13.1	16.7	4.1	-4.1	3.7	-4.0	1.4
Length without tail	1.0	5.3	6.6	2.6	-2.5	2.1	-2.5	1.8
Times rat made contact with spout	0.1	0.1	0.2	-0.2	0.2	-0.3	0.1	0.5
Lifetime Intake	1.4	1.8	4.7	1.2	-1.3	1.1	0.1	2.2
Liver weight, left	0.9	1.6	2.0	1.4	-1.4	1.4	-1.4	0.4
Liver weight, right	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2
Locomotor activity	0.1	0.2	0.3	-0.1	0.2	-0.4	0.5	0.5
Locomotor testing distance	0.1	0.3	1.5	0.3	-0.3	0.0	0.1	1.2
Locomotor testing rearing	0.2	0.8	1.0	1.0	-1.0	0.8	-0.8	0.7
Locomotion in novel chamber	1.1	1.5	2.2	-1.4	1.5	-1.2	1.4	-0.3
Locomotion in novel chamber post-restriction	0.4	1.3	2.5	-0.9	0.9	-0.9	1.6	1.3
Fecal boli incidents, locomotor time 1	0.1	0.3	0.4	0.6	-0.6	0.6	-0.1	0.6
Change in fecal boli incidents, locomotor task	2.8	3.0	4.9	-1.8	1.9	-1.8	2.2	-0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.0	0.1	-0.2	0.2	0.3
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.5	-0.3	0.7	-0.3	-0.8
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.0	0.1	0.2	0.2	-0.5
Rest time, locomotor task time 1	0.9	1.5	2.2	1.5	-1.4	1.2	-0.6	1.2
Distance moved, locomotor task time 1	0.6	1.6	2.3	-1.5	1.4	-1.3	0.5	-1.4
Vertical activity count, locomotor time 1	0.5	3.4	5.1	-2.3	2.2	-1.6	1.5	-1.6
Time >=10cm from walls, locomotor time 2	0.2	0.7	1.2	-0.8	0.9	-1.1	0.9	-0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	-0.2	0.1	-0.0	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.0	0.2	0.3	-0.0
Distance moved, locomotor task time 2	0.2	0.3	0.7	-0.5	0.5	-0.4	-0.1	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.4	-0.6	0.5	-0.3	0.4	-0.2
Light reinforcement 1	0.1	0.6	2.1	-0.6	0.5	-0.0	0.1	-1.5
Light reinforcement 2	0.9	2.0	2.8	-1.7	1.7	-1.4	1.3	-0.9
Bone: marrow area	2.6	6.3	8.4	2.9	-2.9	2.6	-2.3	1.6
Bone: maximum diameter	1.1	2.2	3.2	1.6	-1.6	1.4	-1.8	0.8
Bone: maximum force	2.7	5.3	7.0	2.6	-2.6	2.5	-1.8	1.7
Bone: maximum moment	3.1	5.9	7.8	2.8	-2.8	2.7	-1.9	1.8
Mean time between licks in bursts	0.2	0.9	1.1	-1.0	1.0	-0.8	1.0	-1.0
Mean num. licks in bursts	0.1	0.3	0.8	0.4	-0.4	0.3	-0.1	0.9
Cd content in liver	1.8	2.0	2.8	1.6	-1.6	1.7	-1.5	-0.1
Co content in liver	0.4	0.4	1.2	0.7	-0.7	1.1	0.2	0.3
Cu content in liver	0.7	0.9	1.2	1.1	-1.0	1.1	-0.8	0.6
Fe content in liver	0.2	0.3	0.4	0.6	-0.6	0.6	-0.5	0.2
K content in liver	0.1	0.1	0.1	-0.1	0.1	-0.0	-0.4	-0.4
Mg content in liver	0.1	0.1	0.1	-0.2	0.3	-0.4	-0.1	0.2
Mn content in liver	0.2	0.3	0.9	-0.0	0.1	-0.2	-1.0	-0.5
Na content in liver	2.5	2.8	4.1	-2.0	2.0	-1.9	1.0	-1.2
Rb content in liver	2.7	3.1	5.4	1.9	-1.8	1.7	-2.3	0.3
Se content in liver	1.3	1.6	2.9	-1.5	1.5	-1.7	0.7	-0.4
Sr content in liver	6.0	5.2	7.3	-2.6	2.6	-2.1	2.7	-0.6
Zn content in liver	0.4	0.4	0.7	-0.5	0.6	-0.8	0.7	0.6
Bone: minimum diameter	3.1	5.9	7.9	2.7	-2.7	2.6	-2.8	0.3
Time in familiar zone, hab. session 1	2.1	2.3	4.2	1.8	-1.8	2.0	-0.7	0.5
Time in novel zone, hab. session 1	2.1	2.3	3.3	-1.8	1.8	-1.8	0.7	-1.2
Total zone transitions, hab. session 1	0.4	0.6	1.3	0.5	-0.5	1.0	-0.3	-1.1
Total locomotion distance, hab. session 1	0.2	0.3	1.0	0.2	-0.2	0.6	0.1	-1.0
Locomotion velocity, hab. session 1	0.1	0.2	0.7	0.1	-0.1	0.5	0.1	-0.8
Time in familiar zone, hab. session 2	2.9	3.3	4.2	2.0	-2.0	1.8	-1.5	1.6
Time in novel zone, hab. session 2	1.8	2.0	2.6	-1.6	1.6	-1.5	1.0	-1.2
Total zone transitions, hab. session 2	1.9	2.4	3.2	1.5	-1.5	1.8	-1.8	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.7	-0.0	0.0	0.2	0.0	-0.8
Locomotion velocity, hab. session 2	0.2	0.2	1.1	-0.2	0.2	0.1	0.1	-1.0
Novel to familiar place preference ratio	0.0	0.1	0.2	0.1	-0.2	0.1	-0.4	-0.1
Novelty place preference	0.1	0.2	0.4	0.4	-0.4	0.4	-0.6	-0.1
Time in novel zone, NPP test	0.2	0.2	0.4	0.5	-0.5	0.4	-0.6	0.1
Total zone transitions, NPP test	0.1	0.2	0.5	0.5	-0.5	0.7	-0.2	-0.2
Total locomotion distance, NPP test	0.3	0.4	0.5	0.7	-0.6	0.6	-0.7	-0.1
Locomotion velocity, NPP test	0.3	0.4	0.6	0.6	-0.6	0.7	-0.8	-0.4
Intraocular pressure	0.0	0.1	0.1	-0.3	0.3	-0.2	0.3	0.0
Delta distance traveled before/after self-admin	1.7	1.9	2.7	-1.6	1.6	-1.6	0.7	-1.0
Delta ambulatory time before/after self-admin	0.8	1.4	2.1	-1.4	1.4	-1.4	0.9	-0.6
Parametrial fat weight	1.4	3.3	4.5	-2.0	2.0	-2.1	1.9	-0.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	0.4	-0.3	0.2	-0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	1.0	-0.9	0.9	-1.0	0.9	0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	-0.6	0.6	-0.5	0.7	0.1
Pavlov. Cond. index score	0.3	0.3	0.6	-0.6	0.6	-0.6	0.8	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.5	0.4	-0.5	0.7	0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.4	-0.5	0.3	-0.4	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.5	-0.5	0.6	-0.6	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.7	-0.4	0.4	0.0	-0.2	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	-0.6	0.6	-0.6	0.7	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.0	0.0	-0.2	0.2	0.6
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.5	-0.5	0.6	0.2	1.0
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	-0.9	0.9	-1.1	0.4	-0.5
Pavlov. Cond. change in total contacts	0.3	0.7	1.5	0.4	-0.4	0.4	-1.2	-1.2
Pavlov. Cond. index score	0.1	0.2	0.7	-0.2	0.2	-0.3	-0.5	-0.8
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.6	0.6	-0.8	-0.1	-0.9
Pavlov. Cond. lever contacts	0.2	0.3	0.8	-0.2	0.2	-0.3	-0.5	-0.9
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.7	-0.7	0.8	-0.5	0.3
Pavlov. Cond. intertrial magazine entries	1.8	3.9	5.1	2.2	-2.2	2.3	-2.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.3	0.3	-0.5	-0.3	-0.9
Pavlov. Cond. response bias	0.3	0.4	1.0	0.4	-0.4	0.3	-1.0	-0.7
Time in closed arm before self-admin	0.5	0.9	1.6	1.0	-1.0	1.0	-1.2	0.1
Time in closed arm after self-admin	0.3	0.4	1.7	0.2	-0.3	0.1	0.1	1.3
Time in open arm before self-admin	2.1	2.5	4.2	-1.6	1.7	-1.7	2.1	0.5
Time in open arm after self-admin	0.4	0.5	1.8	-0.4	0.6	-0.3	-0.1	-1.4
Bone: periosteal estimation	2.0	4.7	6.0	2.5	-2.4	2.3	-2.3	0.9
Bone: periosteal perimeter	1.6	3.1	4.1	2.0	-2.0	1.9	-2.0	0.3
Bone: post-yield work	2.7	4.7	5.9	2.4	-2.4	2.2	-2.4	1.3
Progressive ratio test 1 active lever presses	0.4	0.6	1.0	0.8	-0.8	1.0	-0.0	0.9
Progressive ratio test 1 breakpoint	0.4	0.6	1.0	0.8	-0.8	1.0	0.0	1.0
Progressive ratio test 1 inactive lever presses	1.1	3.0	4.0	2.0	-2.0	2.0	-0.8	1.5
Progressive ratio test 2 active lever presses	0.8	1.2	3.3	1.0	-1.0	0.7	-0.2	1.8
Progressive ratio test 2 breakpoint	1.0	1.3	3.4	1.1	-1.1	0.8	-0.3	1.8
Progressive ratio test 2 inactive lever presses	1.2	3.8	5.2	2.3	-2.3	2.2	-1.3	1.5
Incentive Sensitization - Responses	0.8	2.2	2.9	1.7	-1.7	1.3	-1.4	1.4
Incentive Sensitization - Breakpoint	0.7	1.6	2.0	1.4	-1.4	1.0	-1.2	1.3
Sum of active levers in priming session hrs 5-6	0.8	0.7	3.1	-0.2	0.2	-0.0	-0.6	-1.8
Progressive ratio	0.1	0.4	1.6	-0.1	0.0	0.1	-0.6	-1.3
Food seeking constrained by brief footshock	0.9	1.2	5.1	-0.4	0.4	0.6	0.2	-2.3
Seeking ratio, punishment vs. effort	0.2	0.4	0.9	0.7	-0.6	0.9	-0.2	0.2
Retroperitoneal fat weight	3.1	14.1	20.4	-4.1	4.1	-4.5	4.0	0.6
Reaction time number correct	0.1	0.2	0.6	-0.3	0.4	-0.4	0.8	-0.1
Reaction time mean minus median	0.0	0.1	0.3	0.1	0.0	0.0	0.6	0.2
Reaction time mean minus median AUC	0.0	0.1	0.3	0.1	0.1	-0.1	0.5	0.5
Reaction time num false alarms	0.0	0.0	0.1	0.1	0.1	0.1	0.2	0.2
Reaction time num false alarms AUC	0.1	0.3	0.5	-0.4	0.7	-0.3	0.7	-0.4
Reaction time trials correct on left	0.1	0.2	0.6	-0.3	0.4	-0.4	0.8	-0.1
Reaction time trials on left	0.1	0.2	0.6	-0.3	0.4	-0.4	0.8	-0.1
Reaction time mean	0.3	0.7	1.1	1.0	-1.0	0.9	-0.5	0.8
Reaction time mean AUC	0.2	0.4	1.0	0.6	-0.6	0.5	0.0	1.0
Median of all reaction times	0.5	0.7	0.9	1.0	-0.9	0.8	-0.5	0.9
Reaction time omissions	0.1	0.1	0.3	-0.1	0.3	-0.1	0.4	-0.6
Reaction time false alarm rate	0.1	0.1	0.2	-0.2	0.4	-0.0	0.2	-0.4
Reaction time premature initiation rate	0.1	0.1	0.4	0.2	-0.2	0.1	0.1	0.6
Reaction time premature initiations	0.0	0.1	0.4	-0.0	0.1	-0.2	0.5	0.6
Std. dev. reaction times	0.2	0.5	0.8	0.9	-0.8	0.7	-0.2	0.7
Reaction time trials completed	0.1	0.2	0.6	-0.3	0.4	-0.4	0.8	-0.1
Reaction time trials AUC	0.0	0.1	0.5	-0.2	0.3	-0.4	0.7	0.1
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.6	-0.6	0.4	-0.7	0.6
Run reversals in cocaine runway, males	0.3	0.3	1.3	0.1	-0.1	0.1	0.5	1.1
Latency to leave start box in cocaine runway	0.3	0.5	0.8	0.8	-0.9	0.7	-0.5	0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.3	-0.3	0.2	0.0	0.1
Latency to leave start box in cocaine runway, M	1.3	1.3	1.7	1.3	-1.3	1.3	-1.1	0.5
Std. dev. time between licks in bursts	0.5	0.9	3.8	-0.5	0.5	-0.2	0.3	-1.9
Total sessions with >9 infusions	0.8	1.0	1.4	1.0	-1.1	1.2	-0.2	1.1
Short access day 1 total inactive lever presses	0.6	1.3	2.7	1.2	-1.1	0.9	-0.5	1.6
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.6	-0.6	0.5	-0.1	0.5
Short access day 1 total infusions	0.2	0.3	1.1	0.0	-0.0	0.1	0.8	1.0
Short access day 10 total infusions	0.2	0.3	0.8	-0.1	0.1	-0.1	0.9	0.9
Short access total infusions	0.6	0.8	2.1	-0.2	0.2	-0.2	1.3	1.4
Short access day 1 locomotion	0.6	1.0	3.3	0.7	-0.7	0.6	0.3	1.8
Short access day 10 total locomotion	0.1	0.6	1.4	0.9	-0.9	1.2	-0.1	0.1
Short access total locomotion	0.2	0.3	0.5	0.3	-0.3	0.7	0.7	0.5
One hour access (0.3 mA shock)	3.8	4.6	6.3	2.5	-2.5	2.3	-1.7	1.5
Compulsive drug intake	1.7	2.5	4.1	1.7	-1.7	1.6	-2.0	-0.2
One hour access (shock baseline)	0.4	1.0	3.5	0.7	-0.7	0.4	0.3	1.9
Social response proportion	0.7	0.9	1.2	1.1	-1.0	0.8	-0.6	1.0
Social responses	2.5	3.3	4.3	2.1	-2.1	2.0	-2.0	0.5
Social time	2.2	3.5	5.5	2.0	-2.0	2.4	-1.9	-0.6
Soleus weight	0.1	0.2	0.2	0.5	-0.4	0.3	-0.5	0.2
Bone: stiffness	2.1	3.9	5.3	2.3	-2.3	2.2	-1.7	1.1
Tibialis anterior weight	0.5	1.7	2.6	-1.3	1.3	-1.6	1.3	0.7
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.6	0.6	-0.6	0.8	-0.6	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.7	0.8	-0.8	0.5	-0.4	0.6
Time to tail flick, test, before self-admin	0.3	0.4	1.3	-0.5	0.5	0.0	1.1	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.5	0.5	-0.6	-0.0	-0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	2.2	-0.1	0.0	-0.3	0.9	1.5
Delta time to tail flick, test, before/after SA	0.3	0.4	1.4	0.3	-0.4	0.0	-1.2	-0.6
Tibia length	3.5	9.6	12.5	3.5	-3.5	3.2	-3.5	0.9
Ambulatory time before self-admin	0.6	1.8	2.7	1.1	-1.1	1.6	-1.4	-1.5
Ambulatory time after self-admin	1.3	2.1	8.8	-0.2	0.2	0.4	-1.1	-3.0
Bone: tissue strength	0.1	0.1	0.3	0.3	-0.3	0.5	0.4	0.0
Total heroin consumption	0.4	0.5	2.0	-0.1	0.1	-0.1	-0.5	-1.4
Bone: trabecular number	0.1	0.3	0.5	-0.5	0.5	-0.4	0.7	-0.2
Bone: trabecular spacing	0.0	0.1	0.3	0.0	-0.1	-0.0	-0.0	0.6
Bone: trabecular thickness	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	-0.1
Bone: trabecular tissue density	0.4	0.7	1.3	-0.9	0.9	-1.2	0.4	-0.1
Water consumed over 24 hours	0.4	0.8	1.4	1.1	-1.1	1.2	-0.6	0.2
Number of responses in last shaping day	0.3	0.3	1.1	0.0	-0.0	-0.1	0.7	1.0