Hub : Genes

Gp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Gp6	0.09	0.06	6.2e-11	0.06	0.06	0.06	0.06	3.9e-10	9.9e-10	1.7e-09	5.5e-10
2	Brain	gene expression	Gp6	0.06	0.04	1.1e-05	0.05	0.06	0.05	0.06	2.3e-05	5.3e-06	1.2e-05	5.1e-06
3	Liver	gene expression	Gp6	0.02	0.02	3.4e-03	0	0.01	0.01	0.01	1.0e-01	1.2e-02	2.5e-02	2.2e-02
4	LHb	alternative TSS	XM_039097279.2	0.12	0.09	8.6e-03	0.1	0.08	0.09	0.08	2.2e-03	5.9e-03	4.4e-03	6.0e-03
5	PL	gene expression	Gp6	0.06	0.04	2.8e-05	0.04	0.04	0.06	0.04	1.4e-05	2.1e-05	1.9e-07	2.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.1	0.1	-0.3	-0.3	0.3	0.2	0.2
Area under the delay curve	0.4	0.5	1.0	0.7	0.6	-0.6	-1.0	-0.2
BMI with tail	0.4	1.5	2.0	1.4	1.3	-1.4	-1.2	0.0
BMI without tail	0.1	0.2	0.3	-0.4	-0.5	0.3	0.5	-0.3
Body weight	1.2	5.1	6.6	-2.5	-2.5	2.3	2.6	-1.1
Weight adjusted by age	0.3	0.5	1.0	-0.7	-0.8	1.0	0.5	-0.1
Bone surface	2.8	5.0	6.6	-2.5	-2.5	2.4	2.6	-0.4
Bone volume	2.1	3.7	4.8	-2.2	-2.1	2.1	2.1	-0.4
Breakpoint value in progressive ratio session	0.5	0.6	1.4	0.7	0.7	-0.7	0.1	1.2
Number of licking bursts	0.0	0.1	0.1	0.3	0.3	-0.3	-0.1	0.2
Context. condit. distance diff. score	0.1	0.2	0.5	0.3	0.4	-0.3	0.0	0.7
Locomotion velocity, session 1	0.4	0.5	1.2	0.4	0.4	0.1	-0.9	1.1
Locomotion distance, session 1	1.6	2.0	3.2	-1.4	-1.4	1.8	1.5	0.7
Locomotion velocity, session 2	0.3	0.4	0.9	0.6	0.6	-0.2	-0.6	1.0
Locomotion distance, session 2	1.1	1.6	2.6	-1.5	-1.5	1.6	0.9	-0.1
Locomotion velocity, session 3	0.1	0.1	0.1	0.3	0.3	-0.2	-0.1	0.3
Locomotion distance, session 3	0.2	0.2	0.5	-0.2	-0.3	0.5	0.5	0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	0.3	-0.4	0.3	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.3	0.3	-0.4	0.2	0.1
Locomotion velocity, session 7	0.1	0.1	0.4	-0.1	-0.1	0.2	0.4	0.6
Locomotion distance, session 7	0.0	0.1	0.2	-0.0	0.1	0.1	-0.3	0.5
Stereotopy head waving bouts, day 7	0.4	0.4	1.5	-0.4	-0.5	0.4	1.2	0.4
Stereotopy head waving duration, day 7	0.3	0.3	1.1	-0.4	-0.5	0.4	1.1	0.2
Locomotion velocity, session 8	0.3	0.4	1.8	0.2	0.3	-0.0	0.2	1.4
Locomotion distance, session 8	0.1	0.2	0.4	-0.4	-0.3	0.5	0.3	0.6
Degree of sensitization distance	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1	0.1
Degree of sensitization stereotypy	0.1	0.1	0.5	-0.1	-0.2	0.1	0.7	0.2
Conditioned locomotion	0.2	0.2	0.8	-0.1	-0.1	0.2	0.5	0.9
Cocaine response after cond. corrected	1.5	1.8	2.3	1.2	1.3	-1.5	-1.5	-1.1
Cocaine response after cond. not corrected	0.4	0.4	1.8	-0.3	-0.3	0.1	-0.2	-1.4
Cocaine response before conditioning	6.0	7.2	9.6	-3.0	-3.0	3.1	2.8	-0.3
Saline control response	0.3	0.4	1.7	0.1	0.1	0.3	0.6	1.3
Bone: connectivity density	0.0	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.1
Bone: cortical apparent density	0.2	0.2	1.1	0.0	0.0	0.2	-1.1	-0.3
Bone: cortical area	0.9	1.4	2.4	-1.3	-1.3	1.2	1.6	-0.1
Bone: cortical porosity	0.6	0.7	1.5	0.7	0.8	-0.8	0.4	1.2
Bone: cortical porosity	0.4	0.5	1.2	0.2	0.3	-0.5	1.0	1.1
Bone: cortical thickness	0.3	0.5	0.7	0.9	0.8	-0.7	-0.4	0.8
Bone: cortical thickness	0.1	0.1	0.2	-0.2	-0.2	0.4	-0.4	-0.2
Bone: cortical tissue density	0.2	0.3	1.2	0.0	0.0	0.2	-1.1	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	0.5	-0.5	0.1	0.5
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.9	1.4	1.4	-1.4	-1.0	0.3
Condit. Reinf. active responses	0.3	0.3	1.0	-0.3	-0.3	0.3	1.0	0.5
Condit. Reinf. inactive responses	2.8	3.5	5.1	-2.0	-2.0	2.0	2.3	0.4
Incentive salience index mean	0.1	0.1	0.2	-0.2	-0.2	0.3	0.4	0.1
Condit. Reinf. lever presses	0.5	0.8	1.1	-1.0	-1.0	1.1	0.4	-0.6
Condit. Reinf. active minus inactive responses	3.6	4.7	6.5	-2.4	-2.4	2.4	2.6	0.1
Condit. Reinf. active-inactive response ratio	5.1	5.9	7.8	-2.8	-2.8	2.6	2.6	-0.6
Condit. Reinf. active responses	3.1	4.4	7.0	-2.1	-2.1	2.2	2.7	0.9
Condit. Reinf. inactive responses	0.4	0.6	1.9	-0.1	-0.0	0.2	0.9	1.4
Condit. Reinf. lever presses	1.0	1.3	3.4	-1.1	-1.1	0.8	1.8	-0.1
Condit. Reinf. lever reinforcers received	3.9	5.5	8.6	-2.4	-2.4	2.5	2.9	0.9
Conditioned reinforcement - actives	0.8	1.3	5.3	-0.5	-0.6	0.5	-0.6	-2.3
Conditioned reinforcement - inactives	1.8	2.6	3.5	-1.8	-1.8	1.9	0.5	-1.6
Conditioned locomotion	0.2	0.2	0.7	-0.4	-0.4	0.3	-0.1	-0.8
Patch foraging indifference point 0 sec	0.4	0.7	1.5	0.8	0.9	-0.6	-0.3	1.2
Patch foraging indifference point AUC	0.5	0.7	1.1	1.0	0.9	-1.0	-0.8	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.3	0.1	-0.5	0.4
Delay disc. indifference point, 16s delay	0.4	0.4	1.0	0.7	0.6	-1.0	-0.3	0.2
Delay disc. indifference point, 2s delay	1.2	1.3	3.8	0.9	0.9	-0.6	-1.9	-1.0
Delay disc. indifference point, 24s delay	0.5	0.5	0.9	0.8	0.7	-0.9	-0.5	0.6
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	-0.2	-0.3	0.3	-0.3	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.4	0.3	-0.3	-0.6	-0.0
Indifference point function ln k	3.7	6.5	9.4	-2.8	-2.8	3.1	2.7	0.0
Indifference point function log k	3.7	6.5	9.4	-2.8	-2.8	3.1	2.7	0.0
Patch foraging total patch changes 0 sec	0.3	0.6	1.3	0.8	0.9	-0.6	-0.3	1.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.6	0.6	-0.7	-0.3	0.2
Patch foraging total patch changes 18 sec	0.4	0.6	0.9	0.9	1.0	-0.9	-0.2	0.7
Patch foraging total patch changes 24 sec	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.1	-0.5
Patch foraging total patch changes 6 sec	0.8	1.1	1.6	1.2	1.3	-1.3	-0.7	0.7
Patch foraging time to switch 0 sec	1.5	3.2	4.7	1.6	1.5	-2.2	-1.6	-2.0
Patch foraging water rate 0 sec	0.4	0.8	1.1	-0.7	-0.7	1.0	0.7	1.1
Patch foraging water rate 12 sec	1.2	2.5	4.2	-1.7	-1.6	2.0	1.5	0.9
Patch foraging water rate 18 sec	0.7	1.1	1.7	-0.9	-0.9	1.3	1.1	0.9
Patch foraging water rate 24 sec	0.7	1.0	1.5	-1.0	-1.0	1.2	1.1	0.6
Patch foraging water rate 6 sec	5.2	7.5	9.5	-3.1	-3.1	3.1	3.0	-0.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	2.2	0.1	0.1	0.4	0.4	1.5
Distance traveled before self-admin	1.2	1.6	3.2	-1.1	-1.1	1.8	1.1	1.2
Distance traveled after self-admin	1.8	2.2	9.3	0.8	0.8	-0.3	0.5	3.0
Extensor digitorum longus weight	0.3	1.1	1.3	-1.1	-1.2	0.9	1.1	-0.8
Bone: elastic displacement	0.7	0.8	2.5	0.7	0.7	-0.7	0.2	1.6
Bone: elastic work	0.3	0.4	0.6	-0.8	-0.8	0.8	0.5	-0.3
Bone: endosteal estimation	2.9	6.3	8.3	-2.9	-2.9	2.6	2.3	-1.7
Bone: endosteal perimeter	1.9	3.9	5.1	-2.2	-2.2	2.1	2.1	-0.8
Epididymis fat weight	0.1	0.3	1.4	-0.2	-0.2	-0.2	0.2	-1.2
Delta time in closed arm before/after self-admin	0.4	0.4	1.0	0.3	0.3	-0.3	-1.0	-0.7
Delta time in open arm before/after self-admin	2.1	2.1	4.3	-1.2	-1.2	1.4	2.1	1.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.1	0.0	0.3	-0.6	-0.5
Delay discount exponential model param	0.3	0.3	0.8	-0.6	-0.5	0.5	0.9	0.2
Extinction: sum of active levers before priming	0.5	0.5	2.4	0.3	0.3	-0.2	0.3	1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.0	0.0	-0.4	0.3	-0.1
Bone: final force	2.0	3.2	4.3	-2.1	-2.1	2.0	1.0	-1.6
Bone: final moment	2.5	4.0	5.3	-2.3	-2.3	2.3	1.1	-1.7
Food consumed during 24 hour testing period	1.4	2.0	2.7	-1.6	-1.6	1.6	1.3	-0.6
Glucose	1.6	2.5	3.1	1.7	1.8	-1.6	-1.8	0.9
Heart weight	1.4	2.1	2.6	-1.6	-1.6	1.4	1.6	-0.9
Delay discount hyperbolic model param	0.4	0.5	1.2	-0.7	-0.6	0.5	1.1	0.4
Intermittent access intake day 1-15 change	0.4	0.9	1.3	-1.1	-1.2	1.0	0.8	-0.5
Intermittent access intake escalation	0.7	1.5	2.2	-1.5	-1.5	1.3	1.1	-0.7
Intermittent access intake escalation 2	0.2	0.2	0.5	-0.3	-0.3	0.5	0.4	0.7
Intermitt. access day 1 inactive lever presses	0.5	1.9	2.6	-1.6	-1.6	1.4	1.3	-0.8
Intermitt. access day 15 inactive lever presses	1.5	3.1	4.3	-2.0	-2.1	1.8	1.9	-0.6
Intermitt. access escalation Index	0.3	0.4	0.7	0.6	0.6	-0.7	-0.8	0.2
Intermittent access day 1 total infusions	0.6	1.0	2.5	-0.9	-0.9	0.8	0.1	-1.6
Intermittent access day 15 total infusions	1.1	1.7	3.2	-1.4	-1.4	1.1	0.4	-1.8
Intermittent access terminal intake (last 3 days)	1.1	1.5	3.1	-1.3	-1.3	1.1	0.1	-1.7
Intermittent access total infusions	1.9	2.2	4.9	-1.5	-1.5	1.3	0.2	-2.2
Intermittent access day 1 locomotion	1.3	1.6	2.9	-1.3	-1.4	1.2	0.1	-1.7
Intermittent access day 15 total locomotion	0.9	1.6	2.5	-1.4	-1.4	1.6	0.2	-1.2
Intermittent access total locomotion	2.9	3.4	4.6	-2.1	-2.1	2.1	0.7	-1.8
Intermittent access standard deviation	0.1	0.2	0.6	0.4	0.4	-0.4	-0.8	-0.1
Left kidney weight	4.9	22.9	28.9	-5.3	-5.4	5.2	5.3	-1.4
Right kidney weight	5.1	23.1	29.5	-5.4	-5.4	5.0	5.4	-1.8
Cocaine induced anxiety	1.1	1.6	3.6	-1.1	-1.1	1.2	1.9	0.9
Post-drug Anxiety	1.1	1.2	3.3	-0.9	-0.9	0.6	1.8	0.8
Baseline Anxiety	0.6	0.7	1.1	0.7	0.8	-0.9	-1.0	-0.5
Tail length	3.0	11.8	15.1	-3.9	-3.9	3.7	3.8	-1.0
Length with tail	3.0	13.2	16.7	-4.1	-4.1	3.7	4.0	-1.7
Length without tail	1.7	5.4	6.6	-2.6	-2.5	2.1	2.5	-1.9
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.2	-0.3	-0.1	-0.5
Lifetime Intake	1.5	1.8	4.9	-1.2	-1.3	1.1	-0.1	-2.2
Liver weight, left	1.0	1.6	2.0	-1.4	-1.4	1.4	1.4	-0.5
Liver weight, right	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.2
Locomotor activity	0.1	0.2	0.3	0.1	0.2	-0.4	-0.5	-0.6
Locomotor testing distance	0.2	0.3	1.5	-0.3	-0.3	0.0	-0.1	-1.2
Locomotor testing rearing	0.4	0.8	1.0	-1.0	-1.0	0.8	0.8	-0.7
Locomotion in novel chamber	1.2	1.5	2.2	1.4	1.5	-1.2	-1.4	0.4
Locomotion in novel chamber post-restriction	0.8	1.3	2.5	0.9	0.9	-0.9	-1.6	-1.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.6	-0.6	0.6	0.1	-0.7
Change in fecal boli incidents, locomotor task	3.0	3.0	4.9	1.8	1.9	-1.8	-2.2	0.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	0.1	-0.2	-0.2	-0.3
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.5	-0.3	0.7	0.3	0.8
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.0	0.1	0.2	-0.2	0.5
Rest time, locomotor task time 1	1.2	1.5	2.2	-1.5	-1.4	1.2	0.6	-1.3
Distance moved, locomotor task time 1	1.1	1.7	2.3	1.5	1.4	-1.3	-0.5	1.5
Vertical activity count, locomotor time 1	1.4	3.4	5.1	2.3	2.2	-1.6	-1.5	1.7
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.2	0.8	0.9	-1.1	-0.9	0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.2	0.1	0.0	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	-0.3
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.3	0.0
Distance moved, locomotor task time 2	0.2	0.3	0.7	0.5	0.5	-0.4	0.1	0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.6	0.5	-0.3	-0.4	0.3
Light reinforcement 1	0.2	0.6	2.3	0.6	0.5	-0.0	-0.1	1.5
Light reinforcement 2	1.3	2.0	2.8	1.7	1.7	-1.4	-1.3	1.0
Bone: marrow area	2.9	6.4	8.4	-2.9	-2.9	2.6	2.3	-1.7
Bone: maximum diameter	1.2	2.3	3.2	-1.6	-1.6	1.4	1.8	-0.9
Bone: maximum force	3.0	5.4	7.0	-2.6	-2.6	2.5	1.8	-1.8
Bone: maximum moment	3.4	6.0	7.8	-2.8	-2.8	2.7	1.9	-1.9
Mean time between licks in bursts	0.4	0.9	1.1	1.0	1.0	-0.8	-1.0	1.0
Mean num. licks in bursts	0.2	0.3	0.8	-0.4	-0.4	0.3	0.1	-0.9
Cd content in liver	1.8	2.0	2.8	-1.6	-1.6	1.7	1.5	0.0
Co content in liver	0.4	0.4	1.2	-0.7	-0.7	1.1	-0.2	-0.3
Cu content in liver	0.7	0.9	1.2	-1.1	-1.0	1.1	0.8	-0.6
Fe content in liver	0.2	0.3	0.4	-0.6	-0.6	0.6	0.5	-0.3
K content in liver	0.1	0.1	0.2	0.1	0.1	-0.0	0.4	0.4
Mg content in liver	0.1	0.1	0.1	0.2	0.3	-0.4	0.1	-0.2
Mn content in liver	0.2	0.3	0.9	0.0	0.1	-0.2	1.0	0.6
Na content in liver	2.7	2.9	4.1	2.0	2.0	-1.9	-1.0	1.4
Rb content in liver	2.7	3.1	5.4	-1.9	-1.8	1.7	2.3	-0.4
Se content in liver	1.4	1.6	2.9	1.5	1.5	-1.7	-0.7	0.5
Sr content in liver	6.1	5.3	7.3	2.6	2.6	-2.1	-2.7	0.7
Zn content in liver	0.4	0.4	0.7	0.5	0.6	-0.8	-0.7	-0.5
Bone: minimum diameter	3.2	5.9	7.9	-2.7	-2.7	2.6	2.8	-0.5
Time in familiar zone, hab. session 1	2.4	2.4	4.2	-1.8	-1.8	2.0	0.7	-0.6
Time in novel zone, hab. session 1	2.3	2.3	3.3	1.8	1.8	-1.8	-0.7	1.3
Total zone transitions, hab. session 1	0.4	0.6	1.1	-0.5	-0.5	1.0	0.3	1.1
Total locomotion distance, hab. session 1	0.2	0.3	0.9	-0.2	-0.2	0.6	-0.1	1.0
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.1	-0.1	0.5	-0.1	0.8
Time in familiar zone, hab. session 2	3.2	3.3	4.2	-2.0	-2.0	1.8	1.5	-1.7
Time in novel zone, hab. session 2	2.0	2.0	2.6	1.6	1.6	-1.5	-1.0	1.3
Total zone transitions, hab. session 2	1.8	2.3	3.2	-1.5	-1.5	1.8	1.8	0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.7	0.0	0.0	0.2	-0.0	0.8
Locomotion velocity, hab. session 2	0.2	0.2	1.0	0.2	0.2	0.1	-0.1	1.0
Novel to familiar place preference ratio	0.0	0.1	0.2	-0.1	-0.2	0.1	0.4	0.1
Novelty place preference	0.2	0.2	0.4	-0.4	-0.4	0.4	0.6	0.1
Time in novel zone, NPP test	0.2	0.2	0.4	-0.5	-0.5	0.4	0.6	-0.1
Total zone transitions, NPP test	0.1	0.2	0.5	-0.5	-0.5	0.7	0.2	0.1
Total locomotion distance, NPP test	0.3	0.4	0.5	-0.7	-0.6	0.6	0.7	0.0
Locomotion velocity, NPP test	0.3	0.4	0.6	-0.6	-0.6	0.7	0.8	0.3
Intraocular pressure	0.0	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.0
Delta distance traveled before/after self-admin	1.8	1.9	2.7	1.6	1.6	-1.6	-0.7	1.1
Delta ambulatory time before/after self-admin	1.2	1.4	2.1	1.4	1.4	-1.4	-0.9	0.7
Parametrial fat weight	1.4	3.3	4.5	2.0	2.0	-2.1	-1.9	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2	0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	1.0	0.9	0.9	-1.0	-0.9	-0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.6	0.6	-0.5	-0.7	-0.0
Pavlov. Cond. index score	0.3	0.3	0.6	0.6	0.6	-0.6	-0.8	0.1
Pavlov. Cond. latency score	0.2	0.2	0.5	0.5	0.4	-0.5	-0.7	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.4	-0.5	0.3	0.4	-0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.5	-0.5	0.6	0.6	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.7	0.4	0.4	0.0	0.2	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.6	0.6	-0.6	-0.7	0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.0	0.0	-0.2	-0.2	-0.6
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.5	-0.5	0.6	-0.2	-0.9
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	0.9	0.9	-1.1	-0.4	0.5
Pavlov. Cond. change in total contacts	0.4	0.6	1.3	-0.4	-0.4	0.4	1.2	1.1
Pavlov. Cond. index score	0.2	0.2	0.6	0.2	0.2	-0.3	0.5	0.8
Pavlov. Cond. latency score	0.3	0.4	0.7	0.6	0.6	-0.8	0.1	0.8
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.2	0.2	-0.3	0.5	0.8
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.7	-0.7	0.8	0.5	-0.3
Pavlov. Cond. intertrial magazine entries	2.6	3.9	5.1	-2.2	-2.2	2.3	2.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.3	0.3	-0.5	0.3	0.8
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.4	-0.4	0.3	1.0	0.5
Time in closed arm before self-admin	0.7	0.9	1.6	-1.0	-1.0	1.0	1.2	-0.1
Time in closed arm after self-admin	0.3	0.4	1.7	-0.2	-0.3	0.1	-0.1	-1.3
Time in open arm before self-admin	2.3	2.5	4.2	1.6	1.7	-1.7	-2.1	-0.4
Time in open arm after self-admin	0.4	0.5	1.8	0.4	0.6	-0.3	0.1	1.3
Bone: periosteal estimation	2.2	4.7	6.0	-2.5	-2.4	2.3	2.3	-1.1
Bone: periosteal perimeter	1.8	3.1	4.1	-2.0	-2.0	1.9	2.0	-0.4
Bone: post-yield work	3.2	4.8	5.9	-2.4	-2.4	2.2	2.4	-1.3
Progressive ratio test 1 active lever presses	0.5	0.7	1.0	-0.8	-0.8	1.0	0.0	-1.0
Progressive ratio test 1 breakpoint	0.6	0.7	1.1	-0.8	-0.8	1.0	-0.0	-1.1
Progressive ratio test 1 inactive lever presses	2.1	3.1	4.0	-2.0	-2.0	2.0	0.8	-1.7
Progressive ratio test 2 active lever presses	1.0	1.2	3.5	-1.0	-1.0	0.7	0.2	-1.9
Progressive ratio test 2 breakpoint	1.2	1.3	3.6	-1.1	-1.1	0.8	0.3	-1.9
Progressive ratio test 2 inactive lever presses	2.4	3.9	5.2	-2.3	-2.3	2.2	1.3	-1.6
Incentive Sensitization - Responses	1.6	2.3	2.9	-1.7	-1.7	1.3	1.4	-1.5
Incentive Sensitization - Breakpoint	1.3	1.7	2.0	-1.4	-1.4	1.0	1.2	-1.3
Sum of active levers in priming session hrs 5-6	0.7	0.7	3.0	0.2	0.2	-0.0	0.6	1.7
Progressive ratio	0.3	0.4	1.6	0.1	0.0	0.1	0.6	1.3
Food seeking constrained by brief footshock	0.9	1.1	4.9	0.4	0.4	0.6	-0.2	2.2
Seeking ratio, punishment vs. effort	0.3	0.4	0.9	-0.7	-0.6	0.9	0.2	-0.3
Retroperitoneal fat weight	3.3	14.0	20.4	4.1	4.1	-4.5	-4.0	-0.3
Reaction time number correct	0.1	0.2	0.6	0.3	0.4	-0.4	-0.8	0.1
Reaction time mean minus median	0.0	0.1	0.3	-0.1	0.0	0.0	-0.6	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.1	0.1	-0.1	-0.5	-0.5
Reaction time num false alarms	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.5	0.4	0.7	-0.3	-0.7	0.4
Reaction time trials correct on left	0.1	0.2	0.6	0.3	0.4	-0.4	-0.8	0.1
Reaction time trials on left	0.1	0.2	0.6	0.3	0.4	-0.4	-0.8	0.2
Reaction time mean	0.5	0.8	1.1	-1.0	-1.0	0.9	0.5	-0.9
Reaction time mean AUC	0.2	0.4	1.1	-0.6	-0.6	0.5	-0.0	-1.0
Median of all reaction times	0.5	0.7	0.9	-1.0	-0.9	0.8	0.5	-1.0
Reaction time omissions	0.1	0.1	0.4	0.1	0.3	-0.1	-0.4	0.6
Reaction time false alarm rate	0.1	0.1	0.2	0.2	0.4	-0.0	-0.2	0.4
Reaction time premature initiation rate	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.1	-0.6
Reaction time premature initiations	0.1	0.1	0.3	0.0	0.1	-0.2	-0.5	-0.6
Std. dev. reaction times	0.3	0.5	0.8	-0.9	-0.8	0.7	0.2	-0.8
Reaction time trials completed	0.1	0.2	0.6	0.3	0.4	-0.4	-0.8	0.2
Reaction time trials AUC	0.1	0.1	0.5	0.2	0.3	-0.4	-0.7	-0.0
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.6	-0.6	0.4	0.7	-0.6
Run reversals in cocaine runway, males	0.3	0.3	1.3	-0.1	-0.1	0.1	-0.5	-1.1
Latency to leave start box in cocaine runway	0.4	0.5	0.8	-0.8	-0.9	0.7	0.5	-0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.0	-0.1
Latency to leave start box in cocaine runway, M	1.4	1.3	1.7	-1.3	-1.3	1.3	1.1	-0.6
Std. dev. time between licks in bursts	0.6	0.9	3.7	0.5	0.5	-0.2	-0.3	1.9
Total sessions with >9 infusions	0.8	1.0	1.5	-1.0	-1.1	1.2	0.2	-1.2
Short access day 1 total inactive lever presses	1.0	1.3	2.9	-1.2	-1.1	0.9	0.5	-1.7
Short access day 10 total inactive lever presses	0.1	0.3	0.4	-0.6	-0.6	0.5	0.1	-0.6
Short access day 1 total infusions	0.3	0.3	1.1	-0.0	-0.0	0.1	-0.8	-1.1
Short access day 10 total infusions	0.2	0.3	0.8	0.1	0.1	-0.1	-0.9	-0.9
Short access total infusions	0.6	0.8	2.0	0.2	0.2	-0.2	-1.3	-1.4
Short access day 1 locomotion	0.8	1.0	3.5	-0.7	-0.7	0.6	-0.3	-1.9
Short access day 10 total locomotion	0.3	0.6	1.4	-0.9	-0.9	1.2	0.1	-0.2
Short access total locomotion	0.3	0.3	0.5	-0.3	-0.3	0.7	-0.7	-0.6
One hour access (0.3 mA shock)	4.0	4.7	6.3	-2.5	-2.5	2.3	1.7	-1.7
Compulsive drug intake	2.1	2.5	4.1	-1.7	-1.7	1.6	2.0	0.1
One hour access (shock baseline)	0.6	1.0	3.5	-0.7	-0.7	0.4	-0.3	-1.9
Social response proportion	0.8	0.9	1.2	-1.1	-1.0	0.8	0.6	-1.1
Social responses	2.6	3.3	4.3	-2.1	-2.1	2.0	2.0	-0.7
Social time	2.6	3.5	5.5	-2.0	-2.0	2.4	1.9	0.4
Soleus weight	0.1	0.2	0.2	-0.5	-0.4	0.3	0.5	-0.2
Bone: stiffness	2.4	3.9	5.3	-2.3	-2.3	2.2	1.7	-1.2
Tibialis anterior weight	0.5	1.7	2.6	1.3	1.3	-1.6	-1.3	-0.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.6	-0.6	0.8	0.6	0.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	-0.8	-0.8	0.5	0.4	-0.6
Time to tail flick, test, before self-admin	0.4	0.4	1.3	0.5	0.5	0.0	-1.1	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.5	0.5	-0.6	0.0	0.6
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	2.0	0.1	0.0	-0.3	-0.9	-1.4
Delta time to tail flick, test, before/after SA	0.4	0.4	1.4	-0.3	-0.4	0.0	1.2	0.6
Tibia length	3.5	9.7	12.5	-3.5	-3.5	3.2	3.5	-1.2
Ambulatory time before self-admin	1.2	1.8	2.7	-1.1	-1.1	1.6	1.4	1.3
Ambulatory time after self-admin	1.7	2.0	8.6	0.2	0.2	0.4	1.1	2.9
Bone: tissue strength	0.1	0.1	0.3	-0.3	-0.3	0.5	-0.4	-0.1
Total heroin consumption	0.4	0.5	2.0	0.1	0.1	-0.1	0.5	1.4
Bone: trabecular number	0.2	0.3	0.5	0.5	0.5	-0.4	-0.7	0.3
Bone: trabecular spacing	0.1	0.1	0.4	-0.0	-0.1	-0.0	0.0	-0.6
Bone: trabecular thickness	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	0.1
Bone: trabecular tissue density	0.5	0.7	1.3	0.9	0.9	-1.2	-0.4	0.2
Water consumed over 24 hours	0.6	0.8	1.4	-1.1	-1.1	1.2	0.6	-0.3
Number of responses in last shaping day	0.3	0.3	1.0	-0.0	-0.0	-0.1	-0.7	-1.0