Hub : Genes

Gosr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr10_89087914_89095036 0.15 0.07 8.8e-07 0.12 0.14 0.14 0.12 1.0e-05 1.5e-06 2.2e-06 9.3e-06
2 pVTA intron excision ratio chr10_89087914_89095036 0.05 0.03 4.2e-04 0.01 0.02 0.01 0.01 2.5e-02 8.6e-03 5.0e-02 3.4e-02
3 PL intron excision ratio chr10_89087914_89095036 0.1 0.04 8.7e-13 0.14 0.11 0.11 0.12 4.1e-15 4.6e-12 4.1e-12 2.2e-13
4 BLA gene expression Gosr2 0.17 0.07 1.3e-08 0.12 0.13 0.11 0.12 8.3e-07 2.9e-07 1.5e-06 5.9e-07
5 Adipose gene expression Gosr2 0.04 0.02 8.1e-04 0.03 0.01 0.02 0.01 6.4e-04 1.4e-02 1.7e-03 8.5e-03
6 Brain intron excision ratio chr10_89087914_89095036 0.04 0.02 7.1e-04 0.02 0.03 0.02 0.02 8.8e-03 1.7e-03 9.4e-03 3.1e-03
7 NAcc intron excision ratio chr10_89087914_89095036 0.04 0.02 4.5e-08 0.05 0.05 0.05 0.05 6.1e-08 2.9e-08 3.8e-08 3.5e-08
8 PL gene expression Gosr2 0.08 0.04 5.8e-10 0.06 0.09 0.08 0.08 4.7e-07 1.0e-09 3.5e-09 3.5e-09
9 Brain gene expression Gosr2 0.12 0.07 2.4e-05 0.06 0.06 0.05 0.05 6.7e-06 3.2e-06 9.3e-06 1.2e-05
10 LHb isoform ratio NM_031685.2 0.38 0.19 5.1e-03 0.07 0.06 0.12 0.1 9.9e-03 1.7e-02 8.7e-04 1.9e-03
11 PL intron excision ratio chr10_89092497_89095036 0.02 0.01 5.7e-03 0.02 0.02 0.02 0.02 2.8e-03 7.0e-03 5.6e-03 5.4e-03
12 NAcc gene expression Gosr2 0.03 0.02 3.8e-06 0.04 0.03 0.03 0.03 1.3e-06 7.4e-06 2.0e-05 8.8e-06
13 BLA intron excision ratio chr10_89087914_89095036 0.12 0.07 1.0e-04 0.09 0.07 0.05 0.07 1.7e-05 1.0e-04 8.5e-04 1.3e-04
14 IC gene expression Gosr2 0.2 0.1 4.9e-06 0.11 0.11 0.09 0.12 3.5e-05 1.7e-05 1.6e-04 8.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.22.15.62.22.42.00.72.21.61.81.70.80.0-0.70.40.50.5
Area under the delay curve0.10.10.3-0.1-0.2-0.5-0.0-0.2-0.2-0.4-0.3-0.2-0.10.5-0.20.00.0
BMI with tail1.03.39.6-2.0-1.5-1.6-1.3-1.5-3.1-2.1-1.3-1.72.51.1-1.7-1.4-1.5
BMI without tail0.20.64.1-0.7-0.2-0.70.1-0.5-2.0-0.80.1-0.31.70.3-0.1-0.1-0.1
Body weight0.73.311.0-0.9-0.2-0.8-0.9-0.2-3.3-2.0-1.0-2.03.31.2-2.2-1.8-1.7
Weight adjusted by age0.20.30.9-0.2-0.5-0.5-0.1-0.8-0.5-0.9-1.0-0.50.10.6-0.3-0.5-0.5
Bone surface1.52.78.62.92.92.41.22.41.21.51.60.90.0-0.50.40.40.4
Bone volume1.52.78.32.72.92.31.02.41.41.71.70.90.2-0.50.40.50.5
Breakpoint value in progressive ratio session1.01.22.40.80.40.81.50.60.90.80.81.3-1.6-1.01.31.31.3
Number of licking bursts1.52.53.8-1.7-1.7-1.5-1.2-1.5-1.9-1.9-1.8-1.51.51.2-1.6-1.4-1.4
Context. condit. distance diff. score1.21.42.5-1.4-1.3-1.4-1.1-1.1-1.1-1.2-1.1-1.41.61.3-1.0-0.8-0.8
Locomotion velocity, session 11.01.01.51.01.10.80.90.71.01.11.10.9-0.7-1.21.11.21.2
Locomotion distance, session 10.30.40.70.60.70.60.50.70.50.80.80.6-0.3-0.70.60.70.7
Locomotion velocity, session 21.31.63.21.31.21.40.91.11.81.51.21.0-1.3-1.21.01.21.2
Locomotion distance, session 20.91.22.00.70.70.91.10.51.01.21.31.4-1.1-1.31.11.41.4
Locomotion velocity, session 30.30.31.60.00.2-0.3-0.9-0.10.00.1-0.0-0.60.61.3-0.7-0.7-0.7
Locomotion distance, session 31.31.44.3-0.6-0.7-1.2-1.3-0.8-0.7-0.9-1.1-1.30.92.1-1.5-1.4-1.4
Stereotopy head waving bouts, day 30.40.51.70.60.91.3-0.31.01.10.90.80.00.4-0.4-0.10.10.1
Stereotopy head waving duration, day 30.20.31.10.20.41.00.10.80.70.60.60.20.0-0.80.10.30.3
Locomotion velocity, session 70.30.31.6-0.6-0.3-0.2-1.0-0.1-0.1-0.1-0.2-0.91.30.7-0.4-0.3-0.3
Locomotion distance, session 70.10.10.3-0.5-0.5-0.5-0.4-0.2-0.1-0.3-0.3-0.50.50.6-0.3-0.1-0.1
Stereotopy head waving bouts, day 70.20.30.90.60.50.8-0.20.91.00.50.1-0.2-0.1-0.1-0.5-0.2-0.2
Stereotopy head waving duration, day 70.10.20.90.10.00.6-0.20.60.90.40.0-0.0-0.5-0.4-0.4-0.1-0.1
Locomotion velocity, session 80.20.20.9-0.40.1-0.30.2-0.2-0.60.20.70.20.9-0.50.40.50.5
Locomotion distance, session 80.10.20.7-0.3-0.2-0.10.3-0.00.30.30.40.3-0.0-0.30.40.80.8
Degree of sensitization distance0.40.41.8-0.1-0.00.40.80.4-0.20.10.50.6-0.3-1.40.80.90.9
Degree of sensitization stereotypy0.10.10.50.0-0.10.2-0.40.20.5-0.1-0.5-0.5-0.10.2-0.7-0.5-0.5
Conditioned locomotion0.10.10.8-0.1-0.1-0.20.10.30.10.20.20.3-0.9-0.30.0-0.1-0.1
Cocaine response after cond. corrected1.01.22.6-0.20.0-0.4-1.5-0.4-0.6-0.7-0.8-1.41.61.6-1.6-1.4-1.4
Cocaine response after cond. not corrected0.60.71.90.50.70.4-1.10.10.1-0.0-0.3-1.11.41.2-1.0-0.9-0.9
Cocaine response before conditioning1.21.42.51.31.21.60.91.21.41.31.10.8-0.2-1.31.31.11.1
Saline control response0.60.82.1-0.00.0-0.51.1-0.8-0.30.40.81.4-0.7-0.71.31.41.4
Bone: connectivity density1.93.06.22.52.52.31.42.51.81.91.71.3-0.8-1.30.91.01.0
Bone: cortical apparent density0.30.42.8-0.1-0.10.2-0.60.41.70.90.40.2-1.0-0.10.40.30.4
Bone: cortical area0.71.03.91.72.01.4-0.21.30.60.90.80.10.80.7-0.7-0.4-0.4
Bone: cortical porosity2.32.58.82.93.02.21.61.50.61.21.50.90.3-0.80.91.01.0
Bone: cortical porosity0.91.04.71.92.21.20.60.6-0.30.50.80.11.30.00.10.20.2
Bone: cortical thickness1.01.74.50.30.70.4-2.10.60.60.4-0.2-1.31.81.9-1.9-1.7-1.7
Bone: cortical thickness0.50.62.10.90.90.9-0.80.71.40.80.1-0.2-0.40.6-0.6-0.5-0.5
Bone: cortical tissue density0.30.52.9-0.0-0.10.2-0.50.41.71.00.40.3-1.1-0.10.50.40.4
Condit. Reinf. active minus inactive responses1.01.12.51.10.81.21.61.00.70.50.60.9-0.9-1.41.11.11.1
Condit. Reinf. active-inactive response ratio0.20.21.00.4-0.00.50.90.20.3-0.2-0.20.3-1.0-0.60.40.40.4
Condit. Reinf. active responses1.92.44.01.51.31.82.01.41.11.21.41.5-0.9-2.01.71.71.7
Condit. Reinf. inactive responses1.72.13.91.41.71.71.11.41.11.72.01.40.3-1.51.41.41.4
Incentive salience index mean1.41.72.91.51.21.71.71.41.10.90.91.0-0.9-1.41.41.31.3
Condit. Reinf. lever presses1.01.52.41.31.31.51.21.31.21.31.20.9-0.1-1.01.31.31.3
Condit. Reinf. active minus inactive responses3.64.78.12.82.62.62.32.12.02.01.92.0-1.6-2.02.02.02.0
Condit. Reinf. active-inactive response ratio2.02.34.62.11.71.61.91.61.31.11.01.4-1.6-1.11.51.51.5
Condit. Reinf. active responses5.37.410.23.22.93.23.12.52.52.42.52.6-2.1-3.02.62.72.7
Condit. Reinf. inactive responses3.95.19.22.02.02.52.31.82.12.32.42.2-1.3-3.02.32.52.5
Condit. Reinf. lever presses2.12.93.51.91.61.81.91.51.71.61.61.8-1.7-1.71.81.61.6
Condit. Reinf. lever reinforcers received4.66.49.23.02.82.92.72.32.42.32.32.4-1.9-2.72.42.42.4
Conditioned reinforcement - actives0.10.20.4-0.2-0.2-0.20.6-0.2-0.3-0.00.20.6-0.2-0.50.60.40.4
Conditioned reinforcement - inactives0.30.41.00.81.00.80.60.9-0.10.50.80.40.7-0.70.40.50.5
Conditioned locomotion0.10.10.50.10.1-0.30.50.1-0.7-0.5-0.2-0.00.20.00.10.00.0
Patch foraging indifference point 0 sec2.34.27.02.02.42.21.72.31.82.42.62.2-1.0-2.21.71.91.9
Patch foraging indifference point AUC0.10.20.6-0.4-0.40.20.40.2-0.8-0.6-0.3-0.10.4-0.7-0.2-0.1-0.1
Delay disc. indifference point, 0s delay0.30.41.10.2-0.10.40.80.20.50.30.30.6-1.1-0.80.30.90.9
Delay disc. indifference point, 16s delay1.21.32.2-0.8-0.8-1.2-1.0-0.9-1.2-1.3-1.2-1.31.21.5-1.1-1.1-1.1
Delay disc. indifference point, 2s delay2.02.23.71.81.71.21.71.91.51.41.51.5-1.4-1.01.31.31.3
Delay disc. indifference point, 24s delay0.20.20.6-0.2-0.3-0.80.0-0.5-0.6-0.6-0.5-0.20.00.60.20.10.0
Delay disc. indifference point, 4s delay0.00.00.10.1-0.0-0.1-0.0-0.30.1-0.2-0.3-0.1-0.10.2-0.20.00.1
Delay disc. indifference point, 8s delay0.10.10.40.00.0-0.5-0.2-0.20.30.10.00.1-0.60.60.00.20.1
Indifference point function ln k0.71.22.91.61.71.40.51.51.51.31.10.5-0.5-0.20.40.70.7
Indifference point function log k0.71.22.91.61.71.40.51.51.51.31.10.5-0.5-0.20.40.70.7
Patch foraging total patch changes 0 sec2.24.27.12.12.52.31.72.21.72.42.72.1-0.8-2.11.61.91.9
Patch foraging total patch changes 12 sec3.64.78.41.61.71.62.41.51.52.22.52.9-2.0-2.62.22.42.4
Patch foraging total patch changes 18 sec0.10.20.60.50.60.60.50.20.00.30.40.6-0.3-0.80.30.30.3
Patch foraging total patch changes 24 sec1.83.04.91.92.21.81.41.91.52.02.21.8-0.9-1.81.31.51.5
Patch foraging total patch changes 6 sec0.50.81.40.91.11.00.81.20.50.91.11.0-0.3-1.00.60.60.7
Patch foraging time to switch 0 sec0.20.31.5-0.5-0.6-1.0-0.3-1.2-0.3-0.4-0.50.0-0.60.9-0.0-0.3-0.3
Patch foraging water rate 0 sec0.20.41.70.61.01.00.21.30.20.40.7-0.21.0-0.6-0.10.30.3
Patch foraging water rate 12 sec0.91.94.4-0.2-0.2-0.3-1.70.0-0.5-1.1-1.4-1.90.91.5-2.1-2.0-2.1
Patch foraging water rate 18 sec0.40.61.81.01.30.7-0.31.01.31.31.10.3-0.0-0.00.10.00.0
Patch foraging water rate 24 sec0.10.20.80.30.40.0-0.6-0.30.90.60.3-0.1-0.30.6-0.10.00.1
Patch foraging water rate 6 sec0.60.92.61.41.51.50.51.61.00.80.70.10.1-0.70.10.40.5
Seeking ratio, delayed vs. immediate footshock1.51.94.8-1.4-1.5-1.9-0.4-1.6-2.2-1.8-1.4-0.70.41.1-0.9-1.3-1.2
Distance traveled before self-admin0.30.40.70.90.70.90.70.30.80.50.40.6-0.7-0.60.80.60.6
Distance traveled after self-admin0.10.10.5-0.4-0.5-0.20.2-0.7-0.10.0-0.10.4-0.70.0-0.00.10.0
Extensor digitorum longus weight4.015.729.3-5.3-5.4-4.5-2.9-4.7-4.6-4.7-4.3-3.31.92.7-3.0-3.0-3.0
Bone: elastic displacement0.30.30.80.30.30.6-0.70.30.40.1-0.3-0.60.90.5-0.7-0.7-0.7
Bone: elastic work0.40.61.81.21.41.20.10.80.70.90.70.20.8-0.1-0.00.20.2
Bone: endosteal estimation0.81.85.12.11.91.42.31.2-0.00.41.01.2-1.0-0.81.11.21.2
Bone: endosteal perimeter0.61.24.21.91.80.92.00.7-0.70.00.71.1-0.6-0.30.70.90.9
Epididymis fat weight0.00.10.6-0.4-0.30.10.20.2-0.8-0.4-0.1-0.10.3-0.1-0.30.00.1
Delta time in closed arm before/after self-admin2.52.35.4-1.3-0.7-1.2-2.3-1.5-1.2-0.8-0.8-1.82.31.6-1.4-1.6-1.6
Delta time in open arm before/after self-admin2.52.55.80.3-0.01.52.31.40.90.91.11.8-1.7-2.41.91.91.9
Diff in mean of infusions in LGA sessions0.70.91.70.50.41.11.30.80.60.70.81.0-0.9-1.31.11.01.0
Delay discount exponential model param0.10.10.40.10.20.60.00.30.40.40.30.10.1-0.60.2-0.0-0.0
Extinction: sum of active levers before priming0.20.20.7-0.4-0.3-0.60.3-0.4-0.00.40.40.8-0.7-0.10.50.60.6
Active lever presses in extinction session 60.40.41.50.50.30.51.20.2-0.4-0.00.30.8-0.5-0.70.40.70.7
Bone: final force0.81.24.31.72.11.5-0.11.51.11.41.30.40.60.1-0.10.00.0
Bone: final moment1.01.65.32.02.31.7-0.01.71.41.61.50.50.50.1-0.00.10.1
Food consumed during 24 hour testing period0.20.21.1-0.4-0.2-0.3-0.0-0.1-1.0-0.7-0.3-0.51.00.2-0.10.00.0
Glucose1.21.83.2-1.4-1.4-1.5-1.8-1.6-1.1-1.2-1.4-1.40.81.5-1.3-1.1-1.1
Heart weight3.35.18.0-1.7-1.3-2.0-2.2-1.4-2.7-2.1-1.9-2.42.62.6-2.8-2.6-2.5
Delay discount hyperbolic model param0.00.00.1-0.1-0.10.3-0.30.00.10.20.0-0.10.2-0.2-0.0-0.2-0.3
Intermittent access intake day 1-15 change0.71.43.7-1.1-0.9-1.7-1.3-1.9-1.3-0.9-0.8-0.81.41.5-0.5-0.9-0.8
Intermittent access intake escalation0.51.13.7-0.9-0.6-1.8-1.1-1.9-1.1-0.6-0.5-0.51.01.6-0.3-0.6-0.5
Intermittent access intake escalation 20.50.51.9-0.6-0.3-1.3-0.6-1.4-0.9-0.2-0.0-0.21.01.10.2-0.3-0.2
Intermitt. access day 1 inactive lever presses0.20.61.30.91.00.91.11.0-0.30.40.80.80.5-0.90.70.50.5
Intermitt. access day 15 inactive lever presses1.53.15.72.42.02.12.22.21.41.31.31.6-1.7-1.91.41.31.3
Intermitt. access escalation Index1.01.42.5-1.2-1.4-1.5-1.0-1.6-1.1-1.3-1.4-1.0-0.11.5-1.1-1.0-0.9
Intermittent access day 1 total infusions0.10.10.50.0-0.20.10.60.7-0.2-0.3-0.10.1-0.1-0.5-0.10.20.2
Intermittent access day 15 total infusions0.40.62.4-0.7-0.6-1.50.0-1.3-1.2-0.7-0.30.00.50.80.0-0.00.1
Intermittent access terminal intake (last 3 days)0.20.20.8-0.1-0.2-0.90.8-0.5-0.8-0.4-0.10.5-0.10.10.40.40.5
Intermittent access total infusions0.30.41.6-0.7-0.8-1.10.4-0.5-1.3-0.8-0.4-0.00.60.3-0.10.00.1
Intermittent access day 1 locomotion0.20.21.10.00.1-0.20.30.1-1.0-0.6-0.2-0.20.9-0.1-0.3-0.1-0.2
Intermittent access day 15 total locomotion0.20.31.7-0.6-0.4-0.90.2-0.8-1.3-0.7-0.2-0.00.80.00.0-0.1-0.0
Intermittent access total locomotion0.20.21.10.00.1-0.40.8-0.2-1.1-0.50.00.20.6-0.20.30.30.3
Intermittent access standard deviation0.20.51.40.10.3-0.10.80.2-0.10.60.91.00.3-0.61.21.01.0
Left kidney weight0.21.13.2-0.10.20.2-1.30.6-0.6-0.5-0.5-1.61.81.1-1.6-1.3-1.3
Right kidney weight0.62.76.3-0.7-0.4-0.4-1.8-0.1-1.5-1.3-1.2-2.22.41.6-2.5-2.0-2.0
Cocaine induced anxiety0.60.82.1-0.5-0.2-0.4-1.4-0.6-0.5-0.4-0.6-1.11.30.8-1.1-1.2-1.2
Post-drug Anxiety0.50.51.6-0.20.1-0.3-0.9-0.4-0.7-0.4-0.3-0.81.30.6-0.9-1.0-1.0
Baseline Anxiety0.20.31.40.50.20.21.20.3-0.2-0.10.10.7-0.9-0.40.50.40.4
Tail length0.62.45.42.22.32.01.62.21.11.51.71.0-0.0-1.21.11.01.1
Length with tail0.10.62.80.61.00.60.01.0-1.1-0.20.3-0.51.70.3-0.9-0.8-0.7
Length without tail1.44.410.0-1.4-1.1-0.9-2.0-0.6-2.4-2.2-1.9-2.52.51.6-3.2-2.6-2.6
Times rat made contact with spout0.30.32.0-0.4-0.10.1-0.7-0.6-0.6-0.4-0.3-0.81.40.3-0.3-0.3-0.3
Lifetime Intake0.20.20.8-0.3-0.4-0.70.6-0.1-0.9-0.6-0.20.20.40.10.00.20.3
Liver weight, left0.40.72.41.01.31.60.51.3-0.20.30.6-0.11.3-0.8-0.10.20.2
Liver weight, right0.61.12.80.00.20.2-1.60.3-0.1-0.2-0.6-1.41.51.1-1.7-1.5-1.5
Locomotor activity1.32.04.71.31.20.71.80.20.71.31.52.2-1.7-1.31.61.61.6
Locomotor testing distance2.03.67.21.71.50.92.40.41.21.71.92.7-2.4-1.62.22.32.3
Locomotor testing rearing1.83.68.71.10.90.42.3-0.30.91.41.62.7-3.0-1.82.32.52.5
Locomotion in novel chamber0.30.42.61.10.70.30.80.00.4-0.2-0.20.4-1.6-0.30.30.20.2
Locomotion in novel chamber post-restriction0.10.20.60.60.80.60.30.50.00.50.70.40.1-0.30.20.40.3
Fecal boli incidents, locomotor time 10.20.21.0-0.3-0.2-0.9-0.5-1.0-0.20.0-0.10.1-0.20.80.0-0.5-0.3
Change in fecal boli incidents, locomotor task0.10.10.60.20.20.50.20.80.00.00.1-0.10.4-0.5-0.10.10.1
Time >=10cm from walls, locomotor time 10.80.92.1-0.6-0.9-0.2-1.0-0.6-0.2-1.0-1.4-1.30.30.5-1.1-1.3-1.3
Bouts of movement, locomotor time 10.80.91.4-0.9-0.9-0.8-1.1-0.3-0.5-0.9-1.1-1.20.70.9-1.2-1.2-1.2
Total resting periods, locomotor time 11.31.52.6-1.0-1.0-0.9-1.4-0.4-0.8-1.2-1.3-1.61.31.1-1.4-1.5-1.4
Rest time, locomotor task time 10.10.10.4-0.1-0.30.6-0.30.30.3-0.1-0.4-0.40.2-0.4-0.5-0.3-0.3
Distance moved, locomotor task time 10.20.20.9-0.3-0.3-0.70.0-0.5-1.0-0.7-0.4-0.30.30.5-0.3-0.3-0.3
Vertical activity count, locomotor time 10.10.20.8-0.1-0.1-0.6-0.1-0.4-0.6-0.6-0.5-0.60.40.9-0.4-0.3-0.3
Time >=10cm from walls, locomotor time 20.10.10.40.50.40.7-0.2-0.10.0-0.2-0.3-0.40.2-0.2-0.2-0.2-0.3
Bouts of movement, locomotor time 20.10.20.50.60.60.2-0.10.70.60.40.2-0.0-0.10.4-0.1-0.7-0.4
Total resting periods, locomotor time 20.10.21.10.20.2-0.1-0.60.40.30.1-0.1-0.40.20.7-0.4-1.1-0.8
Rest time, locomotor task time 21.01.21.7-1.3-1.3-0.7-1.3-0.9-1.0-1.1-1.2-1.31.10.7-1.2-1.0-1.1
Distance moved, locomotor task time 20.00.00.10.20.1-0.00.2-0.2-0.00.00.00.2-0.40.00.20.00.1
Vertical activity count, locomotor time 20.40.61.01.00.90.80.80.70.80.70.70.7-0.5-0.60.70.70.8
Light reinforcement 11.02.43.81.61.81.51.51.81.51.81.91.7-0.8-1.71.21.21.1
Light reinforcement 21.82.86.51.92.02.01.42.61.81.91.91.2-0.1-1.61.31.21.1
Bone: marrow area0.81.74.92.11.91.42.21.2-0.00.41.01.2-0.9-0.81.11.21.2
Bone: maximum diameter0.71.34.62.12.11.61.01.30.51.01.10.8-0.2-0.20.30.60.6
Bone: maximum force0.40.83.21.51.81.1-0.11.10.30.81.00.20.80.5-0.5-0.3-0.3
Bone: maximum moment0.61.04.21.72.01.30.01.30.61.11.10.30.60.5-0.3-0.1-0.1
Mean time between licks in bursts2.76.511.3-2.4-2.1-2.0-2.3-1.9-3.0-2.7-2.4-2.63.41.9-2.8-2.8-2.8
Mean num. licks in bursts0.81.22.11.21.41.30.61.01.31.41.40.8-0.4-0.71.21.01.0
Cd content in liver0.60.73.0-1.7-1.7-1.1-0.6-1.0-0.4-0.8-0.7-0.40.3-0.2-0.20.00.0
Co content in liver0.40.51.7-0.6-1.2-0.60.8-0.2-0.1-0.8-0.80.1-1.3-0.30.30.50.5
Cu content in liver0.20.31.10.50.20.80.70.70.2-0.2-0.30.0-0.7-1.00.10.00.0
Fe content in liver0.20.20.6-0.1-0.10.8-0.20.60.70.1-0.1-0.70.2-0.60.00.10.1
K content in liver1.01.03.21.10.61.50.81.11.50.70.30.7-1.8-0.90.60.50.5
Mg content in liver1.11.25.20.60.11.10.60.92.00.80.10.8-2.3-1.10.90.70.7
Mn content in liver3.53.98.42.12.12.51.02.62.92.62.01.5-1.2-1.81.41.41.4
Na content in liver1.71.83.71.00.60.91.70.71.41.00.91.4-1.9-1.21.61.71.7
Rb content in liver1.21.48.10.60.20.70.90.31.70.90.41.3-2.8-1.01.00.90.9
Se content in liver1.41.63.3-1.8-1.8-1.1-1.3-1.1-1.0-1.4-1.6-1.40.80.5-1.3-1.2-1.2
Sr content in liver1.81.63.1-0.6-0.8-0.6-1.1-0.4-0.9-1.6-1.7-1.80.71.4-1.6-1.6-1.6
Zn content in liver0.10.10.3-0.2-0.40.0-0.4-0.40.2-0.3-0.6-0.3-0.30.2-0.3-0.2-0.2
Bone: minimum diameter0.91.65.82.42.41.41.71.5-0.30.61.11.0-0.1-0.20.40.50.5
Time in familiar zone, hab. session 10.60.51.9-1.4-1.2-0.8-0.3-0.9-1.2-0.7-0.4-0.20.8-0.1-0.00.30.3
Time in novel zone, hab. session 10.30.30.80.90.70.8-0.10.70.80.2-0.2-0.6-0.10.2-0.5-0.5-0.5
Total zone transitions, hab. session 11.31.82.8-1.7-1.5-1.2-1.3-1.3-1.6-1.5-1.3-1.41.30.9-1.3-1.1-1.1
Total locomotion distance, hab. session 10.20.30.90.70.81.00.21.00.10.30.4-0.10.9-0.4-0.1-0.0-0.0
Locomotion velocity, hab. session 10.20.31.00.70.91.00.51.0-0.00.40.60.20.8-0.6-0.00.10.1
Time in familiar zone, hab. session 20.60.72.0-1.4-1.1-1.1-0.3-0.9-1.3-0.6-0.2-0.21.4-0.10.10.30.3
Time in novel zone, hab. session 20.90.92.61.61.31.50.01.21.60.80.2-0.2-0.90.2-0.5-0.5-0.5
Total zone transitions, hab. session 20.70.92.5-1.5-1.6-1.0-0.7-1.0-0.9-1.2-1.2-0.90.30.4-0.8-0.5-0.5
Total locomotion distance, hab. session 20.20.30.6-0.8-0.80.1-0.20.2-0.5-0.7-0.5-0.60.6-0.5-0.7-0.4-0.4
Locomotion velocity, hab. session 20.20.30.8-0.9-0.80.0-0.30.2-0.5-0.7-0.5-0.60.6-0.6-0.7-0.5-0.5
Novel to familiar place preference ratio0.20.20.80.80.90.60.30.30.20.40.50.4-0.3-0.30.10.00.0
Novelty place preference0.20.20.90.90.90.70.30.40.30.50.50.4-0.3-0.30.00.00.0
Time in novel zone, NPP test0.30.31.00.91.00.90.20.50.40.50.50.2-0.1-0.4-0.1-0.1-0.1
Total zone transitions, NPP test0.10.10.4-0.6-0.6-0.0-0.4-0.0-0.0-0.3-0.3-0.40.3-0.3-0.4-0.2-0.2
Total locomotion distance, NPP test0.30.51.90.60.71.30.21.40.60.40.5-0.20.8-0.8-0.20.10.1
Locomotion velocity, NPP test0.10.20.90.20.30.80.21.00.10.00.2-0.10.6-0.6-0.2-0.0-0.0
Intraocular pressure0.20.41.1-0.5-0.6-0.0-0.00.3-1.0-1.0-0.8-0.50.2-0.5-0.3-0.7-0.7
Delta distance traveled before/after self-admin0.20.20.8-0.9-0.8-0.6-0.3-0.5-0.5-0.1-0.10.1-0.10.3-0.2-0.2-0.2
Delta ambulatory time before/after self-admin0.30.31.1-1.0-0.7-1.0-0.3-0.5-0.9-0.10.10.00.40.6-0.2-0.3-0.3
Parametrial fat weight0.61.53.41.41.71.70.71.81.11.41.40.60.4-1.20.80.90.9
Pavlov. Cond. lever latency0.70.92.6-1.6-1.6-1.0-1.1-1.1-0.4-0.8-1.0-0.7-0.10.3-0.6-0.7-0.7
Pavlov. Cond. magazine entry latency5.36.89.93.03.12.82.52.92.42.83.02.3-0.9-2.22.52.62.6
Pavlov. Cond. change in total contacts3.23.45.32.12.02.32.12.31.51.61.71.4-0.5-2.01.81.91.9
Pavlov. Cond. index score3.24.06.72.52.62.22.12.31.62.12.31.7-0.5-1.61.81.91.9
Pavlov. Cond. latency score2.32.95.12.22.31.81.81.81.21.82.01.6-0.5-1.31.51.61.6
Pavlov. Cond. lever contacts1.11.32.91.71.71.21.41.20.71.11.21.0-0.2-0.71.11.11.1
Pavlov. Cond. magazine entry number7.19.011.3-3.2-3.3-3.2-2.9-3.1-2.9-3.3-3.4-2.81.62.7-3.0-3.1-3.1
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.7-0.7-0.80.5-0.8-0.9-0.6-0.20.20.0-0.20.30.40.4
Pavlov. Cond. lever-magazine prob. diff.3.54.47.62.72.82.42.12.51.82.12.31.7-0.5-1.61.81.91.9
Pavlov. Cond. response bias6.58.012.93.53.63.32.73.42.73.03.12.3-0.9-2.22.52.62.6
Pavlov. Cond. lever latency0.50.61.0-1.0-0.8-0.8-0.8-0.7-0.9-0.8-0.7-0.91.00.8-0.7-0.5-0.5
Pavlov. Cond. magazine entry latency0.50.61.2-1.0-1.1-0.8-0.8-0.9-0.5-0.8-0.9-0.70.00.7-0.7-0.9-0.9
Pavlov. Cond. change in total contacts1.32.17.70.90.40.52.00.51.10.80.81.8-2.8-1.51.91.61.6
Pavlov. Cond. index score0.10.21.30.40.10.10.50.00.40.1-0.00.4-1.2-0.10.30.10.1
Pavlov. Cond. latency score0.10.10.90.40.10.10.40.10.40.1-0.00.3-1.00.00.30.10.1
Pavlov. Cond. lever contacts0.50.61.00.90.80.80.80.61.00.90.70.9-1.0-0.90.70.50.5
Pavlov. Cond. magazine entry number0.40.60.90.70.90.80.90.90.10.40.70.40.6-1.00.70.90.9
Pavlov. Cond. intertrial magazine entries1.72.54.52.02.12.02.02.10.41.01.51.00.8-1.81.31.61.6
Pavlov. Cond. lever-magazine prob. diff.0.10.11.00.2-0.1-0.10.3-0.10.3-0.0-0.20.2-1.00.10.1-0.1-0.1
Pavlov. Cond. response bias0.30.41.50.60.50.50.50.20.90.70.50.8-1.2-0.60.60.40.4
Time in closed arm before self-admin0.10.10.3-0.10.10.4-0.30.10.50.50.40.3-0.4-0.50.0-0.00.0
Time in closed arm after self-admin1.92.05.6-1.6-1.0-1.0-2.4-1.4-0.8-0.7-0.8-1.61.71.3-1.4-1.6-1.5
Time in open arm before self-admin4.95.47.9-1.7-1.7-2.3-2.4-2.5-2.2-2.3-2.5-2.61.92.8-2.4-2.4-2.4
Time in open arm after self-admin0.30.31.4-0.2-0.60.11.2-0.1-0.8-0.5-0.20.5-0.4-0.50.70.60.6
Bone: periosteal estimation1.02.07.12.72.71.91.51.80.51.01.31.0-0.2-0.20.40.60.6
Bone: periosteal perimeter0.30.52.41.61.50.70.50.4-0.40.00.20.10.20.9-0.4-0.2-0.2
Bone: post-yield work0.91.33.7-0.4-0.3-0.9-0.7-0.9-1.9-1.4-1.1-1.00.81.4-1.4-1.4-1.4
Progressive ratio test 1 active lever presses0.30.41.30.70.50.51.20.80.20.20.40.6-0.4-0.60.70.80.8
Progressive ratio test 1 breakpoint0.50.61.70.80.60.71.31.00.20.30.60.7-0.3-0.80.81.01.0
Progressive ratio test 1 inactive lever presses1.11.52.71.41.41.31.71.50.40.91.31.20.2-1.41.21.21.3
Progressive ratio test 2 active lever presses0.30.41.50.70.50.41.20.7-0.10.10.30.7-0.4-0.60.70.60.6
Progressive ratio test 2 breakpoint0.40.41.70.70.50.31.30.7-0.10.10.40.7-0.5-0.60.80.60.7
Progressive ratio test 2 inactive lever presses0.20.31.10.40.40.21.00.6-0.5-0.00.40.60.3-0.60.50.40.5
Incentive Sensitization - Responses0.20.21.00.80.5-0.01.00.3-0.1-0.2-0.10.6-0.8-0.10.40.10.2
Incentive Sensitization - Breakpoint0.20.31.10.80.4-0.01.00.3-0.1-0.2-0.00.6-0.9-0.20.50.20.3
Sum of active levers in priming session hrs 5-60.50.52.7-0.1-0.8-0.30.9-0.30.6-0.1-0.30.7-1.6-0.20.70.80.8
Progressive ratio0.40.61.90.40.4-0.30.9-0.20.40.70.91.3-1.4-0.21.30.80.8
Food seeking constrained by brief footshock0.40.51.1-0.4-0.4-0.31.0-0.6-0.40.10.40.9-0.6-0.70.90.91.0
Seeking ratio, punishment vs. effort0.10.10.5-0.3-0.40.30.20.1-0.5-0.4-0.3-0.30.7-0.5-0.30.10.2
Retroperitoneal fat weight0.10.31.30.40.50.70.61.10.30.40.60.3-0.2-0.80.50.50.5
Reaction time number correct0.20.40.8-0.2-0.2-0.1-0.6-0.2-0.5-0.6-0.7-0.80.90.5-0.8-0.9-0.9
Reaction time mean minus median0.10.20.80.40.30.70.70.50.30.20.20.3-0.2-0.90.40.40.4
Reaction time mean minus median AUC0.30.81.50.80.71.20.70.91.20.90.60.7-0.8-1.20.70.70.7
Reaction time num false alarms0.20.31.60.40.60.70.10.5-0.5-0.20.1-0.41.3-0.20.1-0.3-0.3
Reaction time num false alarms AUC0.20.31.10.60.80.90.30.8-0.30.10.4-0.11.0-0.50.4-0.2-0.1
Reaction time trials correct on left0.20.40.8-0.2-0.2-0.1-0.6-0.2-0.5-0.6-0.7-0.80.90.5-0.8-0.9-0.9
Reaction time trials on left0.20.30.7-0.1-0.1-0.0-0.5-0.1-0.4-0.6-0.6-0.80.80.4-0.7-0.8-0.8
Reaction time mean0.91.42.71.00.71.31.31.11.41.10.81.2-1.3-1.61.21.01.0
Reaction time mean AUC0.81.22.20.90.51.21.21.01.41.00.71.1-1.3-1.51.11.01.0
Median of all reaction times1.01.42.31.10.71.31.31.11.51.10.81.2-1.4-1.51.21.00.9
Reaction time omissions4.05.98.72.92.62.82.52.32.62.42.12.2-2.3-2.42.32.12.2
Reaction time false alarm rate0.20.30.70.60.70.80.60.7-0.00.40.60.20.5-0.60.70.30.3
Reaction time premature initiation rate0.30.41.00.70.90.20.70.40.10.71.00.8-0.0-0.20.70.50.5
Reaction time premature initiations0.20.30.90.70.90.30.60.5-0.00.60.90.70.3-0.30.50.40.4
Std. dev. reaction times0.91.63.81.10.91.81.31.41.51.21.01.1-1.0-2.01.11.11.1
Reaction time trials completed0.20.30.7-0.1-0.1-0.0-0.5-0.1-0.4-0.6-0.6-0.80.80.4-0.7-0.8-0.8
Reaction time trials AUC0.10.20.5-0.1-0.1-0.1-0.5-0.2-0.4-0.5-0.6-0.70.60.4-0.6-0.7-0.7
Run reversals in cocaine runway, females3.33.35.4-1.0-1.0-1.3-1.9-1.0-1.8-2.0-2.0-2.21.52.0-2.1-2.3-2.2
Run reversals in cocaine runway, males0.10.10.40.60.70.0-0.3-0.3-0.3-0.00.00.00.10.4-0.2-0.0-0.2
Latency to leave start box in cocaine runway0.60.72.5-0.8-0.5-0.7-0.9-0.4-0.7-0.6-0.5-1.01.60.9-0.8-0.7-0.8
Latency to leave start box in cocaine runway, F3.84.38.2-1.7-1.5-1.8-2.2-1.4-1.9-2.0-1.9-2.62.92.5-2.3-1.9-2.0
Latency to leave start box in cocaine runway, M2.72.54.11.11.21.31.51.11.61.71.82.0-1.5-1.92.01.61.4
Std. dev. time between licks in bursts0.50.71.6-1.0-1.0-1.3-0.3-1.0-1.1-1.0-0.8-0.40.30.6-0.7-0.7-0.7
Total sessions with >9 infusions0.80.92.0-1.1-1.2-0.9-0.3-0.6-1.3-1.4-1.2-1.00.90.5-0.9-0.7-0.7
Short access day 1 total inactive lever presses0.10.10.40.70.60.30.10.3-0.2-0.4-0.4-0.30.50.1-0.3-0.3-0.3
Short access day 10 total inactive lever presses0.20.41.21.01.01.00.71.1-0.00.30.50.40.2-0.80.00.10.0
Short access day 1 total infusions0.10.20.40.30.20.20.60.40.30.10.20.4-0.4-0.40.30.60.7
Short access day 10 total infusions0.10.10.3-0.1-0.1-0.30.50.1-0.5-0.3-0.10.10.4-0.1-0.00.10.1
Short access total infusions0.10.10.30.10.00.00.50.5-0.2-0.3-0.10.00.3-0.2-0.10.30.3
Short access day 1 locomotion0.00.10.20.40.4-0.10.40.0-0.4-0.3-0.20.0-0.10.1-0.0-0.0-0.0
Short access day 10 total locomotion0.20.41.50.40.5-0.11.2-0.1-0.90.10.61.00.3-0.50.70.60.5
Short access total locomotion0.30.32.2-0.1-0.1-0.60.5-0.4-1.5-0.9-0.4-0.10.90.2-0.2-0.3-0.2
One hour access (0.3 mA shock)0.30.31.0-0.3-0.3-1.0-0.3-0.7-0.7-0.6-0.5-0.40.21.0-0.4-0.4-0.3
Compulsive drug intake0.30.30.8-0.0-0.1-0.1-0.8-0.20.1-0.3-0.6-0.8-0.20.8-0.9-0.8-0.8
One hour access (shock baseline)0.20.41.5-0.5-0.6-0.90.2-0.6-1.2-0.9-0.5-0.30.90.3-0.0-0.10.0
Social response proportion2.73.05.2-1.3-1.3-1.6-1.3-1.3-2.3-2.1-1.9-1.81.51.7-1.9-1.9-2.0
Social responses0.10.10.4-0.10.1-0.5-0.1-0.5-0.6-0.1-0.00.00.30.2-0.2-0.2-0.2
Social time0.91.22.8-0.5-0.7-0.8-0.5-0.8-1.7-1.5-1.4-0.91.00.7-1.2-1.3-1.3
Soleus weight0.72.23.2-1.1-1.2-1.2-1.3-1.3-1.8-1.8-1.7-1.51.31.2-1.6-1.7-1.7
Bone: stiffness0.00.10.20.20.4-0.1-0.10.2-0.10.30.50.10.20.3-0.10.10.1
Tibialis anterior weight0.61.94.9-1.8-1.9-1.7-0.4-1.8-2.2-1.8-1.5-0.70.50.4-1.1-0.9-0.9
Time to tail flick, vehicle, before self-admin0.30.30.90.40.40.8-0.60.40.90.1-0.2-0.90.6-0.1-0.7-0.4-0.3
Time to tail flick, vehicle, after self-admin0.91.23.61.11.31.21.21.90.81.01.30.9-0.2-1.10.90.90.9
Time to tail flick, test, before self-admin1.11.12.4-1.3-1.6-0.7-0.7-1.0-0.9-1.4-1.5-1.20.30.5-1.0-0.9-0.8
Time to tail flick, test, after self-admin0.00.00.10.0-0.00.10.40.20.0-0.1-0.00.1-0.1-0.30.10.10.1
Delta time to tail flick, vehicle, before/after SA1.61.63.21.21.20.71.81.60.41.01.41.6-0.9-1.11.41.31.3
Delta time to tail flick, test, before/after SA1.21.22.01.31.20.91.41.00.91.01.11.4-0.9-1.11.11.11.1
Tibia length0.72.010.1-0.9-0.0-0.5-2.0-0.3-1.2-0.3-0.1-1.63.21.5-1.4-1.4-1.4
Ambulatory time before self-admin0.30.40.80.90.70.80.60.00.80.60.40.7-0.8-0.50.70.50.4
Ambulatory time after self-admin0.10.10.30.00.1-0.00.1-0.40.00.40.40.6-0.40.00.10.0-0.0
Bone: tissue strength0.30.31.4-0.8-0.3-0.1-0.8-0.2-0.30.10.2-0.41.20.2-0.5-0.4-0.4
Total heroin consumption1.51.84.91.40.90.81.70.61.31.00.91.7-2.2-0.91.51.41.4
Bone: trabecular number2.54.19.12.93.02.51.52.72.02.42.31.6-0.8-1.41.11.21.2
Bone: trabecular spacing1.11.53.7-1.9-1.9-1.7-0.5-1.9-1.6-1.4-1.1-0.60.90.4-0.2-0.2-0.2
Bone: trabecular thickness0.50.62.01.31.41.0-0.11.40.30.30.4-0.40.50.4-0.6-0.6-0.6
Bone: trabecular tissue density0.20.30.70.40.60.7-0.40.90.70.60.4-0.30.7-0.10.1-0.2-0.2
Water consumed over 24 hours0.40.61.4-0.4-0.1-0.1-1.2-0.3-0.5-0.4-0.5-1.11.20.9-0.9-0.8-0.8
Number of responses in last shaping day0.20.32.00.50.70.20.10.2-0.7-0.20.1-0.41.40.3-0.2-0.1-0.1