Hub : Genes

Gosr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr10_89087914_89095036 0.15 0.07 8.8e-07 0.12 0.14 0.14 0.12 1.0e-05 1.5e-06 2.2e-06 9.8e-06
2 pVTA intron excision ratio chr10_89087914_89095036 0.05 0.03 4.2e-04 0.01 0.02 0.01 0.01 2.5e-02 8.6e-03 5.0e-02 3.5e-02
3 PL intron excision ratio chr10_89087914_89095036 0.1 0.04 8.7e-13 0.14 0.11 0.11 0.12 4.1e-15 4.6e-12 4.1e-12 2.3e-13
4 BLA gene expression Gosr2 0.17 0.07 1.3e-08 0.12 0.13 0.11 0.12 8.3e-07 2.9e-07 1.5e-06 6.6e-07
5 Adipose gene expression Gosr2 0.04 0.02 8.1e-04 0.03 0.01 0.02 0.01 6.4e-04 1.4e-02 1.7e-03 8.0e-03
6 Brain intron excision ratio chr10_89087914_89095036 0.04 0.02 7.1e-04 0.02 0.03 0.02 0.02 8.8e-03 1.7e-03 9.4e-03 3.0e-03
7 NAcc intron excision ratio chr10_89087914_89095036 0.04 0.02 4.5e-08 0.05 0.05 0.05 0.05 6.1e-08 2.9e-08 3.8e-08 3.6e-08
8 PL gene expression Gosr2 0.08 0.04 5.8e-10 0.06 0.09 0.08 0.08 4.7e-07 1.0e-09 3.5e-09 3.3e-09
9 Brain gene expression Gosr2 0.12 0.07 2.4e-05 0.06 0.06 0.05 0.05 6.7e-06 3.2e-06 9.3e-06 1.3e-05
10 LHb isoform ratio NM_031685.2 0.38 0.19 5.1e-03 0.07 0.06 0.12 0.1 9.9e-03 1.7e-02 9.1e-04 2.1e-03
11 PL intron excision ratio chr10_89092497_89095036 0.02 0.01 5.7e-03 0.02 0.02 0.02 0.02 2.8e-03 7.0e-03 5.6e-03 5.0e-03
12 NAcc gene expression Gosr2 0.03 0.02 3.8e-06 0.04 0.03 0.03 0.03 1.3e-06 7.4e-06 2.0e-05 9.1e-06
13 BLA intron excision ratio chr10_89087914_89095036 0.12 0.07 1.0e-04 0.09 0.07 0.05 0.07 1.7e-05 1.0e-04 8.5e-04 1.3e-04
14 IC gene expression Gosr2 0.2 0.1 4.9e-06 0.11 0.11 0.09 0.12 3.5e-05 1.7e-05 1.6e-04 8.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.22.15.62.22.4-2.00.7-2.21.61.81.70.80.00.7-0.4-0.50.5
Area under the delay curve0.00.10.3-0.1-0.20.5-0.00.2-0.2-0.4-0.3-0.20.1-0.50.2-0.00.0
BMI with tail0.93.39.6-2.0-1.51.6-1.31.5-3.1-2.1-1.3-1.7-2.5-1.11.71.4-1.5
BMI without tail0.10.74.1-0.7-0.20.70.10.5-2.0-0.80.1-0.3-1.7-0.30.10.1-0.1
Body weight0.73.311.0-0.9-0.20.8-0.90.2-3.3-2.0-1.0-2.0-3.3-1.22.21.8-1.7
Weight adjusted by age0.10.30.9-0.2-0.50.5-0.10.8-0.5-0.9-1.0-0.5-0.1-0.60.30.5-0.5
Bone surface1.42.78.62.92.9-2.41.2-2.41.21.51.60.90.00.5-0.4-0.40.4
Bone volume1.32.78.32.72.9-2.31.0-2.41.41.71.70.9-0.10.5-0.4-0.50.5
Breakpoint value in progressive ratio session0.61.22.40.80.4-0.81.5-0.60.90.80.81.31.51.0-1.3-1.31.3
Number of licking bursts0.82.53.8-1.7-1.71.5-1.21.5-1.9-1.9-1.8-1.5-1.5-1.21.61.4-1.4
Context. condit. distance diff. score1.21.42.5-1.4-1.31.4-1.11.1-1.1-1.2-1.1-1.4-1.6-1.31.00.8-0.8
Locomotion velocity, session 10.91.01.51.01.1-0.80.9-0.71.01.11.10.90.71.2-1.1-1.21.2
Locomotion distance, session 10.30.40.70.60.7-0.60.5-0.70.50.80.80.60.30.7-0.6-0.70.7
Locomotion velocity, session 21.31.63.21.31.2-1.40.9-1.11.81.51.21.01.31.2-1.0-1.21.2
Locomotion distance, session 20.91.22.00.70.7-0.91.1-0.51.01.21.31.41.11.3-1.1-1.41.4
Locomotion velocity, session 30.30.31.60.00.20.3-0.90.10.00.1-0.0-0.6-0.6-1.30.70.7-0.7
Locomotion distance, session 31.31.44.3-0.6-0.71.2-1.30.8-0.7-0.9-1.1-1.3-0.9-2.11.51.4-1.4
Stereotopy head waving bouts, day 30.40.51.70.60.9-1.3-0.3-1.01.10.90.80.0-0.40.40.1-0.10.1
Stereotopy head waving duration, day 30.20.31.10.20.4-1.00.1-0.80.70.60.60.2-0.00.8-0.1-0.30.3
Locomotion velocity, session 70.30.31.6-0.6-0.30.2-1.00.1-0.1-0.1-0.2-0.9-1.3-0.70.40.3-0.3
Locomotion distance, session 70.10.10.3-0.5-0.50.5-0.40.2-0.1-0.3-0.3-0.5-0.5-0.60.30.1-0.1
Stereotopy head waving bouts, day 70.20.30.90.60.5-0.8-0.2-0.91.00.50.1-0.20.20.10.50.2-0.2
Stereotopy head waving duration, day 70.10.20.90.10.0-0.6-0.2-0.60.90.40.0-0.00.50.40.40.1-0.1
Locomotion velocity, session 80.20.20.9-0.40.10.30.20.2-0.60.20.70.2-1.00.5-0.4-0.50.5
Locomotion distance, session 80.10.20.7-0.3-0.20.10.30.00.30.30.40.30.00.3-0.4-0.80.8
Degree of sensitization distance0.40.41.8-0.1-0.0-0.40.8-0.4-0.20.10.50.60.21.4-0.8-0.90.9
Degree of sensitization stereotypy0.10.10.50.0-0.1-0.2-0.4-0.20.5-0.1-0.5-0.50.1-0.20.70.5-0.5
Conditioned locomotion0.10.10.8-0.1-0.10.20.1-0.30.10.20.20.30.90.3-0.00.1-0.1
Cocaine response after cond. corrected0.81.22.6-0.20.00.4-1.50.4-0.6-0.7-0.8-1.4-1.6-1.61.61.4-1.4
Cocaine response after cond. not corrected0.50.71.80.50.7-0.4-1.1-0.10.1-0.0-0.3-1.1-1.3-1.21.00.9-0.9
Cocaine response before conditioning1.21.42.51.31.2-1.60.9-1.21.41.31.10.80.21.3-1.3-1.11.1
Saline control response0.60.82.1-0.00.00.51.10.8-0.30.40.81.40.70.7-1.3-1.41.4
Bone: connectivity density1.93.06.22.52.5-2.31.4-2.51.81.91.71.30.91.3-0.9-1.01.0
Bone: cortical apparent density0.30.42.8-0.1-0.1-0.2-0.6-0.41.70.90.40.21.00.1-0.4-0.30.4
Bone: cortical area0.61.03.91.72.0-1.4-0.2-1.30.60.90.80.1-0.7-0.70.70.4-0.4
Bone: cortical porosity2.32.58.82.93.0-2.21.6-1.50.61.21.50.9-0.30.8-0.9-1.01.0
Bone: cortical porosity0.91.04.71.92.2-1.20.6-0.6-0.30.50.80.1-1.3-0.0-0.1-0.20.2
Bone: cortical thickness1.01.74.50.30.7-0.4-2.1-0.60.60.4-0.2-1.3-1.7-1.91.91.7-1.7
Bone: cortical thickness0.50.62.10.90.9-0.9-0.8-0.71.40.80.1-0.20.4-0.60.60.5-0.5
Bone: cortical tissue density0.30.52.9-0.0-0.1-0.2-0.5-0.41.71.00.40.31.10.1-0.5-0.40.4
Condit. Reinf. active minus inactive responses0.91.12.51.10.8-1.21.6-1.00.70.50.60.90.91.4-1.1-1.11.1
Condit. Reinf. active-inactive response ratio0.20.21.00.4-0.0-0.50.9-0.20.3-0.2-0.20.31.00.6-0.4-0.40.4
Condit. Reinf. active responses1.82.44.01.51.3-1.82.0-1.41.11.21.41.50.92.0-1.7-1.71.7
Condit. Reinf. inactive responses1.62.13.91.41.7-1.71.1-1.41.11.72.01.4-0.31.5-1.4-1.41.4
Incentive salience index mean1.31.72.91.51.2-1.71.7-1.41.10.90.91.00.91.4-1.4-1.31.3
Condit. Reinf. lever presses1.01.52.41.31.3-1.51.2-1.31.21.31.20.90.11.0-1.3-1.31.3
Condit. Reinf. active minus inactive responses3.04.78.12.82.6-2.62.3-2.12.02.01.92.01.62.0-2.0-2.02.0
Condit. Reinf. active-inactive response ratio1.52.34.62.11.7-1.61.9-1.61.31.11.01.41.61.1-1.5-1.51.5
Condit. Reinf. active responses5.27.410.23.22.9-3.23.1-2.52.52.42.52.62.23.0-2.6-2.72.7
Condit. Reinf. inactive responses3.55.19.22.02.0-2.52.3-1.82.12.32.42.21.33.0-2.3-2.52.5
Condit. Reinf. lever presses2.02.93.51.91.6-1.81.9-1.51.71.61.61.81.71.7-1.8-1.61.6
Condit. Reinf. lever reinforcers received4.56.49.23.02.8-2.92.7-2.32.42.32.32.42.02.7-2.4-2.42.4
Conditioned reinforcement - actives0.00.20.4-0.2-0.20.20.60.2-0.3-0.00.20.60.20.5-0.6-0.40.4
Conditioned reinforcement - inactives0.20.41.00.81.0-0.80.6-0.9-0.10.50.80.4-0.70.7-0.4-0.50.5
Conditioned locomotion0.10.10.50.10.10.30.5-0.1-0.7-0.5-0.2-0.0-0.2-0.0-0.1-0.00.0
Patch foraging indifference point 0 sec1.54.27.02.02.4-2.21.7-2.31.82.42.62.21.02.2-1.7-1.91.9
Patch foraging indifference point AUC0.10.20.6-0.4-0.4-0.20.4-0.2-0.8-0.6-0.3-0.1-0.40.70.20.1-0.1
Delay disc. indifference point, 0s delay0.30.41.10.2-0.1-0.40.8-0.20.50.30.30.61.10.8-0.3-0.90.9
Delay disc. indifference point, 16s delay0.91.32.2-0.8-0.81.2-1.00.9-1.2-1.3-1.2-1.3-1.2-1.51.11.1-1.1
Delay disc. indifference point, 2s delay2.02.23.71.81.7-1.21.7-1.91.51.41.51.51.41.0-1.3-1.31.3
Delay disc. indifference point, 24s delay0.10.20.6-0.2-0.30.80.00.5-0.6-0.6-0.5-0.2-0.0-0.6-0.2-0.10.0
Delay disc. indifference point, 4s delay0.00.00.10.1-0.00.1-0.00.30.1-0.2-0.3-0.10.1-0.20.2-0.00.1
Delay disc. indifference point, 8s delay0.10.10.40.00.00.5-0.20.20.30.10.00.10.6-0.6-0.0-0.20.1
Indifference point function ln k0.41.22.91.61.7-1.40.5-1.51.51.31.10.50.50.2-0.4-0.70.7
Indifference point function log k0.41.22.91.61.7-1.40.5-1.51.51.31.10.50.50.2-0.4-0.70.7
Patch foraging total patch changes 0 sec1.44.27.12.12.5-2.31.7-2.21.72.42.72.10.82.1-1.6-1.91.9
Patch foraging total patch changes 12 sec3.54.78.41.61.7-1.62.4-1.51.52.22.52.92.02.6-2.2-2.42.4
Patch foraging total patch changes 18 sec0.10.20.60.50.6-0.60.5-0.20.00.30.40.60.30.8-0.3-0.30.3
Patch foraging total patch changes 24 sec0.93.04.91.92.2-1.81.4-1.91.52.02.21.80.91.8-1.3-1.51.5
Patch foraging total patch changes 6 sec0.50.81.40.91.1-1.00.8-1.20.50.91.11.00.31.0-0.6-0.60.7
Patch foraging time to switch 0 sec0.10.31.5-0.5-0.61.0-0.31.2-0.3-0.4-0.50.00.6-0.90.00.3-0.3
Patch foraging water rate 0 sec0.10.41.70.61.0-1.00.2-1.30.20.40.7-0.2-1.00.60.1-0.30.3
Patch foraging water rate 12 sec0.51.94.4-0.2-0.20.3-1.7-0.0-0.5-1.1-1.4-1.9-0.9-1.52.12.0-2.1
Patch foraging water rate 18 sec0.30.61.81.01.3-0.7-0.3-1.01.31.31.10.30.10.0-0.1-0.00.0
Patch foraging water rate 24 sec0.10.20.80.30.4-0.0-0.60.30.90.60.3-0.10.3-0.60.1-0.00.1
Patch foraging water rate 6 sec0.60.92.61.41.5-1.50.5-1.61.00.80.70.1-0.00.7-0.1-0.40.5
Seeking ratio, delayed vs. immediate footshock1.31.94.8-1.4-1.51.9-0.41.6-2.2-1.8-1.4-0.7-0.5-1.10.91.3-1.2
Distance traveled before self-admin0.20.40.70.90.7-0.90.7-0.30.80.50.40.60.70.6-0.8-0.60.6
Distance traveled after self-admin0.10.10.5-0.4-0.50.20.20.7-0.10.0-0.10.40.7-0.00.0-0.10.0
Extensor digitorum longus weight3.915.729.3-5.3-5.44.5-2.94.7-4.6-4.7-4.3-3.3-2.0-2.73.03.0-3.0
Bone: elastic displacement0.20.30.80.30.3-0.6-0.7-0.30.40.1-0.3-0.6-0.9-0.50.70.7-0.7
Bone: elastic work0.40.61.81.21.4-1.20.1-0.80.70.90.70.2-0.70.10.0-0.20.2
Bone: endosteal estimation0.71.85.12.11.9-1.42.3-1.2-0.00.41.01.21.00.8-1.1-1.21.2
Bone: endosteal perimeter0.51.24.21.91.8-0.92.0-0.7-0.70.00.71.10.60.3-0.7-0.90.9
Epididymis fat weight0.00.10.6-0.4-0.3-0.10.2-0.2-0.8-0.4-0.1-0.1-0.30.10.3-0.00.1
Delta time in closed arm before/after self-admin2.52.35.4-1.3-0.71.2-2.31.5-1.2-0.8-0.8-1.8-2.3-1.61.41.6-1.6
Delta time in open arm before/after self-admin2.12.55.80.3-0.0-1.52.3-1.40.90.91.11.81.72.4-1.9-1.91.9
Diff in mean of infusions in LGA sessions0.50.91.70.50.4-1.11.3-0.80.60.70.81.00.91.3-1.1-1.01.0
Delay discount exponential model param0.10.10.40.10.2-0.60.0-0.30.40.40.30.1-0.10.6-0.20.0-0.0
Extinction: sum of active levers before priming0.20.20.7-0.4-0.30.60.30.4-0.00.40.40.80.60.1-0.5-0.60.6
Active lever presses in extinction session 60.30.41.50.50.3-0.51.2-0.2-0.4-0.00.30.80.50.7-0.4-0.70.7
Bone: final force0.71.24.31.72.1-1.5-0.1-1.51.11.41.30.4-0.6-0.10.1-0.00.0
Bone: final moment1.01.65.32.02.3-1.7-0.0-1.71.41.61.50.5-0.5-0.10.0-0.10.1
Food consumed during 24 hour testing period0.10.21.1-0.4-0.20.3-0.00.1-1.0-0.7-0.3-0.5-1.0-0.20.1-0.00.0
Glucose1.11.83.2-1.4-1.41.5-1.81.6-1.1-1.2-1.4-1.4-0.8-1.51.31.1-1.1
Heart weight3.15.18.0-1.7-1.32.0-2.21.4-2.7-2.1-1.9-2.4-2.6-2.62.82.6-2.5
Delay discount hyperbolic model param0.00.00.1-0.1-0.1-0.3-0.3-0.00.10.20.0-0.1-0.20.20.00.2-0.3
Intermittent access intake day 1-15 change0.31.43.7-1.1-0.91.7-1.31.9-1.3-0.9-0.8-0.8-1.4-1.50.50.9-0.8
Intermittent access intake escalation0.21.13.7-0.9-0.61.8-1.11.9-1.1-0.6-0.5-0.5-1.0-1.60.30.6-0.5
Intermittent access intake escalation 20.30.51.9-0.6-0.31.3-0.61.4-0.9-0.2-0.0-0.2-1.0-1.1-0.20.3-0.2
Intermitt. access day 1 inactive lever presses0.00.61.30.91.0-0.91.1-1.0-0.30.40.80.8-0.50.9-0.7-0.50.5
Intermitt. access day 15 inactive lever presses0.63.25.72.42.0-2.12.2-2.21.41.31.31.61.71.9-1.4-1.31.3
Intermitt. access escalation Index0.51.42.5-1.2-1.41.5-1.01.6-1.1-1.3-1.4-1.00.1-1.51.11.0-0.9
Intermittent access day 1 total infusions0.00.10.50.0-0.2-0.10.6-0.7-0.2-0.3-0.10.10.10.50.1-0.20.2
Intermittent access day 15 total infusions0.20.62.4-0.7-0.61.50.01.3-1.2-0.7-0.30.0-0.5-0.8-0.00.00.1
Intermittent access terminal intake (last 3 days)0.10.20.8-0.1-0.20.90.80.5-0.8-0.4-0.10.50.0-0.1-0.4-0.40.5
Intermittent access total infusions0.30.41.6-0.7-0.81.10.40.5-1.3-0.8-0.4-0.0-0.6-0.30.1-0.00.1
Intermittent access day 1 locomotion0.10.21.10.00.10.20.3-0.1-1.0-0.6-0.2-0.2-0.90.10.30.1-0.2
Intermittent access day 15 total locomotion0.10.41.7-0.6-0.40.90.20.8-1.3-0.7-0.2-0.0-0.8-0.0-0.00.1-0.0
Intermittent access total locomotion0.20.21.10.00.10.40.80.2-1.1-0.50.00.2-0.60.2-0.3-0.30.3
Intermittent access standard deviation0.10.51.40.10.30.10.8-0.2-0.10.60.91.0-0.30.6-1.2-1.01.0
Left kidney weight0.11.13.1-0.10.2-0.2-1.3-0.6-0.6-0.5-0.5-1.6-1.8-1.11.61.3-1.3
Right kidney weight0.42.76.3-0.7-0.40.4-1.80.1-1.5-1.3-1.2-2.2-2.4-1.62.52.0-2.0
Cocaine induced anxiety0.30.82.1-0.5-0.20.4-1.40.6-0.5-0.4-0.6-1.1-1.3-0.81.11.2-1.2
Post-drug Anxiety0.40.51.6-0.20.10.3-0.90.4-0.7-0.4-0.3-0.8-1.3-0.60.91.0-1.0
Baseline Anxiety0.20.31.40.50.2-0.21.2-0.3-0.2-0.10.10.70.90.4-0.5-0.40.4
Tail length0.42.45.42.22.3-2.01.6-2.21.11.51.71.00.11.2-1.1-1.01.1
Length with tail0.10.62.80.61.0-0.60.0-1.0-1.1-0.20.3-0.5-1.7-0.30.90.8-0.7
Length without tail0.84.410.0-1.4-1.10.9-2.00.6-2.4-2.2-1.9-2.5-2.5-1.63.22.6-2.6
Times rat made contact with spout0.30.32.0-0.4-0.1-0.1-0.70.6-0.6-0.4-0.3-0.8-1.4-0.30.30.3-0.3
Lifetime Intake0.20.20.8-0.3-0.40.70.60.1-0.9-0.6-0.20.2-0.4-0.1-0.0-0.20.3
Liver weight, left0.40.72.41.01.3-1.60.5-1.3-0.20.30.6-0.1-1.30.80.1-0.20.2
Liver weight, right0.61.12.80.00.2-0.2-1.6-0.3-0.1-0.2-0.6-1.4-1.5-1.11.71.5-1.5
Locomotor activity1.32.04.71.31.2-0.71.8-0.20.71.31.52.21.71.3-1.6-1.61.6
Locomotor testing distance1.53.67.21.71.5-0.92.4-0.41.21.71.92.72.41.6-2.2-2.32.3
Locomotor testing rearing1.03.68.61.10.9-0.42.30.30.91.41.62.72.91.8-2.3-2.52.5
Locomotion in novel chamber0.30.42.61.10.7-0.30.8-0.00.4-0.2-0.20.41.60.3-0.3-0.20.2
Locomotion in novel chamber post-restriction0.10.20.60.60.8-0.60.3-0.50.00.50.70.4-0.10.3-0.2-0.40.3
Fecal boli incidents, locomotor time 10.10.21.0-0.3-0.20.9-0.51.0-0.20.0-0.10.10.2-0.8-0.00.5-0.3
Change in fecal boli incidents, locomotor task0.10.10.60.20.2-0.50.2-0.80.00.00.1-0.1-0.40.50.1-0.10.1
Time >=10cm from walls, locomotor time 10.70.92.1-0.6-0.90.2-1.00.6-0.2-1.0-1.4-1.3-0.3-0.51.11.3-1.3
Bouts of movement, locomotor time 10.70.91.4-0.9-0.90.8-1.10.3-0.5-0.9-1.1-1.2-0.7-0.91.21.2-1.2
Total resting periods, locomotor time 11.31.52.6-1.0-1.00.9-1.40.4-0.8-1.2-1.3-1.6-1.3-1.11.41.5-1.4
Rest time, locomotor task time 10.10.10.4-0.1-0.3-0.6-0.3-0.30.3-0.1-0.4-0.4-0.20.40.50.3-0.3
Distance moved, locomotor task time 10.10.20.9-0.3-0.30.70.00.5-1.0-0.7-0.4-0.3-0.3-0.50.30.3-0.3
Vertical activity count, locomotor time 10.00.20.8-0.1-0.10.6-0.10.4-0.6-0.6-0.5-0.6-0.4-0.90.40.3-0.3
Time >=10cm from walls, locomotor time 20.00.10.40.50.4-0.7-0.20.10.0-0.2-0.3-0.4-0.20.20.20.2-0.3
Bouts of movement, locomotor time 20.10.20.50.60.6-0.2-0.1-0.70.60.40.2-0.00.1-0.40.10.7-0.4
Total resting periods, locomotor time 20.10.21.10.20.20.1-0.6-0.40.30.1-0.1-0.4-0.1-0.70.41.1-0.8
Rest time, locomotor task time 20.71.21.7-1.3-1.30.7-1.30.9-1.0-1.1-1.2-1.3-1.1-0.71.21.0-1.1
Distance moved, locomotor task time 20.00.00.10.20.10.00.20.2-0.00.00.00.20.4-0.0-0.2-0.00.1
Vertical activity count, locomotor time 20.20.61.01.00.9-0.80.8-0.70.80.70.70.70.50.6-0.7-0.70.8
Light reinforcement 10.52.43.81.61.8-1.51.5-1.81.51.81.91.70.81.7-1.2-1.21.1
Light reinforcement 21.22.86.51.92.0-2.01.4-2.61.81.91.91.20.11.6-1.3-1.21.1
Bone: marrow area0.71.74.92.11.9-1.42.2-1.2-0.00.41.01.21.00.8-1.1-1.21.2
Bone: maximum diameter0.71.34.62.12.1-1.61.0-1.30.51.01.10.80.30.2-0.3-0.60.6
Bone: maximum force0.40.83.21.51.8-1.1-0.1-1.10.30.81.00.2-0.8-0.50.50.3-0.3
Bone: maximum moment0.51.04.21.72.0-1.30.0-1.30.61.11.10.3-0.6-0.50.30.1-0.1
Mean time between licks in bursts1.16.511.4-2.4-2.12.0-2.31.9-3.0-2.7-2.4-2.6-3.4-1.92.82.8-2.8
Mean num. licks in bursts0.41.22.11.21.4-1.30.6-1.01.31.41.40.80.40.7-1.2-1.01.0
Cd content in liver0.60.73.0-1.7-1.71.1-0.61.0-0.4-0.8-0.7-0.4-0.40.20.2-0.00.0
Co content in liver0.40.51.6-0.6-1.20.60.80.2-0.1-0.8-0.80.11.30.3-0.3-0.50.5
Cu content in liver0.20.31.10.50.2-0.80.7-0.70.2-0.2-0.30.00.71.0-0.1-0.00.0
Fe content in liver0.10.20.6-0.1-0.1-0.8-0.2-0.60.70.1-0.1-0.7-0.20.6-0.0-0.10.1
K content in liver1.01.03.31.10.6-1.50.8-1.11.50.70.30.71.80.9-0.6-0.50.5
Mg content in liver1.11.25.30.60.1-1.10.6-0.92.00.80.10.82.31.1-0.9-0.70.7
Mn content in liver3.53.98.42.12.1-2.51.0-2.62.92.62.01.51.21.8-1.4-1.41.4
Na content in liver1.61.83.71.00.6-0.91.7-0.71.41.00.91.41.91.2-1.6-1.71.7
Rb content in liver1.21.48.10.60.2-0.70.9-0.31.70.90.41.32.81.0-1.0-0.90.9
Se content in liver1.41.63.3-1.8-1.81.1-1.31.1-1.0-1.4-1.6-1.4-0.8-0.51.31.2-1.2
Sr content in liver1.81.63.1-0.6-0.80.6-1.10.4-0.9-1.6-1.7-1.8-0.7-1.41.61.6-1.6
Zn content in liver0.10.10.3-0.2-0.4-0.0-0.40.40.2-0.3-0.6-0.30.3-0.20.30.2-0.2
Bone: minimum diameter0.81.65.82.42.4-1.41.7-1.5-0.30.61.11.00.10.2-0.4-0.50.5
Time in familiar zone, hab. session 10.50.61.9-1.4-1.20.8-0.30.9-1.2-0.7-0.4-0.2-0.80.10.0-0.30.3
Time in novel zone, hab. session 10.30.30.80.90.7-0.8-0.1-0.70.80.2-0.2-0.60.2-0.20.50.5-0.5
Total zone transitions, hab. session 11.31.82.8-1.7-1.51.2-1.31.3-1.6-1.5-1.3-1.4-1.4-0.91.31.1-1.1
Total locomotion distance, hab. session 10.20.30.90.70.8-1.00.2-1.00.10.30.4-0.1-0.90.40.10.0-0.0
Locomotion velocity, hab. session 10.20.31.00.70.9-1.00.5-1.0-0.00.40.60.2-0.70.60.0-0.10.1
Time in familiar zone, hab. session 20.60.72.1-1.4-1.11.1-0.30.9-1.3-0.6-0.2-0.2-1.50.1-0.1-0.30.3
Time in novel zone, hab. session 20.90.92.61.61.3-1.50.0-1.21.60.80.2-0.20.9-0.20.50.5-0.5
Total zone transitions, hab. session 20.70.92.5-1.5-1.61.0-0.71.0-0.9-1.2-1.2-0.9-0.3-0.40.80.5-0.5
Total locomotion distance, hab. session 20.20.30.6-0.8-0.8-0.1-0.2-0.2-0.5-0.7-0.5-0.6-0.60.50.70.4-0.4
Locomotion velocity, hab. session 20.20.30.8-0.9-0.8-0.0-0.3-0.2-0.5-0.7-0.5-0.6-0.60.60.70.5-0.5
Novel to familiar place preference ratio0.20.20.80.80.9-0.60.3-0.30.20.40.50.40.30.3-0.1-0.00.0
Novelty place preference0.20.20.90.90.9-0.70.3-0.40.30.50.50.40.30.3-0.0-0.00.0
Time in novel zone, NPP test0.20.31.00.91.0-0.90.2-0.50.40.50.50.20.20.40.10.1-0.1
Total zone transitions, NPP test0.10.10.4-0.6-0.60.0-0.40.0-0.0-0.3-0.3-0.4-0.30.30.40.2-0.2
Total locomotion distance, NPP test0.30.51.90.60.7-1.30.2-1.40.60.40.5-0.2-0.80.80.2-0.10.1
Locomotion velocity, NPP test0.10.20.90.20.3-0.80.2-1.00.10.00.2-0.1-0.60.60.20.0-0.0
Intraocular pressure0.20.41.1-0.5-0.60.0-0.0-0.3-1.0-1.0-0.8-0.5-0.20.50.30.7-0.7
Delta distance traveled before/after self-admin0.20.20.8-0.9-0.80.6-0.30.5-0.5-0.1-0.10.10.1-0.30.20.2-0.2
Delta ambulatory time before/after self-admin0.20.31.1-1.0-0.71.0-0.30.5-0.9-0.10.10.0-0.4-0.60.20.3-0.3
Parametrial fat weight0.61.53.41.41.7-1.70.7-1.81.11.41.40.6-0.41.2-0.8-0.90.9
Pavlov. Cond. lever latency0.70.92.6-1.6-1.61.0-1.11.1-0.4-0.8-1.0-0.70.1-0.30.60.7-0.7
Pavlov. Cond. magazine entry latency5.36.89.93.03.1-2.82.5-2.92.42.83.02.30.92.2-2.5-2.62.6
Pavlov. Cond. change in total contacts3.13.45.32.12.0-2.32.1-2.31.51.61.71.40.52.0-1.8-1.91.9
Pavlov. Cond. index score3.14.06.72.52.6-2.22.1-2.31.62.12.31.70.51.6-1.8-1.91.9
Pavlov. Cond. latency score2.32.95.12.22.3-1.81.8-1.81.21.82.01.60.51.3-1.5-1.61.6
Pavlov. Cond. lever contacts1.11.42.91.71.7-1.21.4-1.20.71.11.21.00.20.7-1.1-1.11.1
Pavlov. Cond. magazine entry number7.19.011.3-3.2-3.33.2-2.93.1-2.9-3.3-3.4-2.8-1.6-2.73.03.1-3.1
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.7-0.70.80.50.8-0.9-0.6-0.20.2-0.00.2-0.3-0.40.4
Pavlov. Cond. lever-magazine prob. diff.3.54.47.62.72.8-2.42.1-2.51.82.12.31.70.51.6-1.8-1.91.9
Pavlov. Cond. response bias6.48.012.93.53.6-3.32.7-3.42.73.03.12.31.02.2-2.5-2.62.6
Pavlov. Cond. lever latency0.40.61.0-1.0-0.80.8-0.80.7-0.9-0.8-0.7-0.9-1.0-0.80.70.5-0.5
Pavlov. Cond. magazine entry latency0.40.61.2-1.0-1.10.8-0.80.9-0.5-0.8-0.9-0.7-0.0-0.70.70.9-0.9
Pavlov. Cond. change in total contacts0.92.17.60.90.4-0.52.0-0.51.10.80.81.82.81.5-1.9-1.61.6
Pavlov. Cond. index score0.10.21.30.40.1-0.10.5-0.00.40.1-0.00.41.20.1-0.3-0.10.1
Pavlov. Cond. latency score0.10.10.90.40.1-0.10.4-0.10.40.1-0.00.31.0-0.0-0.3-0.10.1
Pavlov. Cond. lever contacts0.40.61.00.90.8-0.80.8-0.61.00.90.70.91.00.9-0.7-0.50.5
Pavlov. Cond. magazine entry number0.40.50.90.70.9-0.80.9-0.90.10.40.70.4-0.61.0-0.7-0.90.9
Pavlov. Cond. intertrial magazine entries1.22.54.52.02.1-2.02.0-2.10.41.01.51.0-0.81.8-1.3-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.10.11.00.2-0.10.10.30.10.3-0.0-0.20.21.0-0.1-0.10.1-0.1
Pavlov. Cond. response bias0.30.41.50.60.5-0.50.5-0.20.90.70.50.81.20.6-0.6-0.40.4
Time in closed arm before self-admin0.10.10.3-0.10.1-0.4-0.3-0.10.50.50.40.30.40.5-0.00.00.0
Time in closed arm after self-admin1.82.05.6-1.6-1.01.0-2.41.4-0.8-0.7-0.8-1.6-1.7-1.31.41.6-1.5
Time in open arm before self-admin4.45.47.9-1.7-1.72.3-2.42.5-2.2-2.3-2.5-2.6-1.8-2.82.42.4-2.4
Time in open arm after self-admin0.30.31.4-0.2-0.6-0.11.20.1-0.8-0.5-0.20.50.40.5-0.7-0.60.6
Bone: periosteal estimation0.82.07.12.72.7-1.91.5-1.80.51.01.31.00.30.2-0.4-0.60.6
Bone: periosteal perimeter0.30.52.41.61.5-0.70.5-0.4-0.40.00.20.1-0.2-0.90.40.2-0.2
Bone: post-yield work0.81.33.7-0.4-0.30.9-0.70.9-1.9-1.4-1.1-1.0-0.8-1.41.41.4-1.4
Progressive ratio test 1 active lever presses0.20.41.30.70.5-0.51.2-0.80.20.20.40.60.40.6-0.7-0.80.8
Progressive ratio test 1 breakpoint0.30.61.70.80.6-0.71.3-1.00.20.30.60.70.30.8-0.8-1.01.0
Progressive ratio test 1 inactive lever presses0.61.52.71.41.4-1.31.7-1.50.40.91.31.2-0.21.4-1.2-1.21.3
Progressive ratio test 2 active lever presses0.30.41.50.70.5-0.41.2-0.7-0.10.10.30.70.40.6-0.7-0.60.6
Progressive ratio test 2 breakpoint0.30.41.70.70.5-0.31.3-0.7-0.10.10.40.70.50.6-0.8-0.60.7
Progressive ratio test 2 inactive lever presses0.10.31.10.40.4-0.21.0-0.6-0.5-0.00.40.6-0.30.6-0.5-0.40.5
Incentive Sensitization - Responses0.10.21.00.80.50.01.0-0.3-0.1-0.2-0.10.60.80.1-0.4-0.10.2
Incentive Sensitization - Breakpoint0.10.31.10.80.40.01.0-0.3-0.1-0.2-0.00.60.90.2-0.5-0.20.3
Sum of active levers in priming session hrs 5-60.50.52.6-0.1-0.80.30.90.30.6-0.1-0.30.71.60.2-0.7-0.80.8
Progressive ratio0.20.61.90.40.40.30.90.20.40.70.91.31.40.2-1.3-0.80.8
Food seeking constrained by brief footshock0.40.51.1-0.4-0.40.31.00.6-0.40.10.40.90.60.7-0.9-0.91.0
Seeking ratio, punishment vs. effort0.10.10.5-0.3-0.4-0.30.2-0.1-0.5-0.4-0.3-0.3-0.70.50.3-0.10.2
Retroperitoneal fat weight0.10.31.30.40.5-0.70.6-1.10.30.40.60.30.20.8-0.5-0.50.5
Reaction time number correct0.10.40.8-0.2-0.20.1-0.60.2-0.5-0.6-0.7-0.8-0.9-0.50.80.9-0.9
Reaction time mean minus median0.00.20.80.40.3-0.70.7-0.50.30.20.20.30.20.9-0.4-0.40.4
Reaction time mean minus median AUC0.10.81.50.80.7-1.20.7-0.91.20.90.60.70.81.2-0.7-0.70.7
Reaction time num false alarms0.10.31.60.40.6-0.70.1-0.5-0.5-0.20.1-0.4-1.30.2-0.10.3-0.3
Reaction time num false alarms AUC0.10.31.10.60.8-0.90.3-0.8-0.30.10.4-0.1-1.00.5-0.40.2-0.1
Reaction time trials correct on left0.10.40.8-0.2-0.20.1-0.60.2-0.5-0.6-0.7-0.8-0.9-0.50.80.9-0.9
Reaction time trials on left0.10.30.7-0.1-0.10.0-0.50.1-0.4-0.6-0.6-0.8-0.8-0.40.70.8-0.8
Reaction time mean0.61.42.71.00.7-1.31.3-1.11.41.10.81.21.31.6-1.2-1.01.0
Reaction time mean AUC0.51.22.20.90.5-1.21.2-1.01.41.00.71.11.41.5-1.1-1.01.0
Median of all reaction times0.91.42.31.10.7-1.31.3-1.11.51.10.81.21.51.5-1.2-1.00.9
Reaction time omissions3.65.98.72.92.6-2.82.5-2.32.62.42.12.22.32.4-2.3-2.12.2
Reaction time false alarm rate0.20.30.70.60.7-0.80.6-0.7-0.00.40.60.2-0.50.6-0.7-0.30.3
Reaction time premature initiation rate0.20.41.00.70.9-0.20.7-0.40.10.71.00.80.00.2-0.7-0.50.5
Reaction time premature initiations0.10.30.90.70.9-0.30.6-0.5-0.00.60.90.7-0.30.3-0.5-0.40.4
Std. dev. reaction times0.51.63.81.10.9-1.81.3-1.41.51.21.01.11.02.0-1.1-1.11.1
Reaction time trials completed0.10.30.7-0.1-0.10.0-0.50.1-0.4-0.6-0.6-0.8-0.8-0.40.70.8-0.8
Reaction time trials AUC0.10.20.5-0.1-0.10.1-0.50.2-0.4-0.5-0.6-0.7-0.6-0.40.60.7-0.7
Run reversals in cocaine runway, females2.93.35.4-1.0-1.01.3-1.91.0-1.8-2.0-2.0-2.2-1.5-2.02.12.3-2.2
Run reversals in cocaine runway, males0.10.10.40.60.7-0.0-0.30.3-0.3-0.00.00.0-0.1-0.40.20.0-0.2
Latency to leave start box in cocaine runway0.50.72.5-0.8-0.50.7-0.90.4-0.7-0.6-0.5-1.0-1.6-0.90.80.7-0.8
Latency to leave start box in cocaine runway, F3.54.38.1-1.7-1.51.8-2.21.4-1.9-2.0-1.9-2.6-2.9-2.52.31.9-2.0
Latency to leave start box in cocaine runway, M2.62.54.11.11.2-1.31.5-1.11.61.71.82.01.51.9-2.0-1.61.4
Std. dev. time between licks in bursts0.40.71.6-1.0-1.01.3-0.31.0-1.1-1.0-0.8-0.4-0.3-0.60.70.7-0.7
Total sessions with >9 infusions0.80.92.0-1.1-1.20.9-0.30.6-1.3-1.4-1.2-1.0-0.9-0.50.90.7-0.7
Short access day 1 total inactive lever presses0.10.10.40.70.6-0.30.1-0.3-0.2-0.4-0.4-0.3-0.5-0.10.30.3-0.3
Short access day 10 total inactive lever presses0.10.41.21.01.0-1.00.7-1.1-0.00.30.50.4-0.20.8-0.0-0.10.0
Short access day 1 total infusions0.10.20.40.30.2-0.20.6-0.40.30.10.20.40.40.4-0.3-0.60.7
Short access day 10 total infusions0.00.10.3-0.1-0.10.30.5-0.1-0.5-0.3-0.10.1-0.40.10.0-0.10.1
Short access total infusions0.10.10.30.10.0-0.00.5-0.5-0.2-0.3-0.10.0-0.30.20.1-0.30.3
Short access day 1 locomotion0.00.10.20.40.40.10.4-0.0-0.4-0.3-0.20.00.1-0.10.00.0-0.0
Short access day 10 total locomotion0.10.41.50.40.50.11.20.1-0.90.10.61.0-0.30.5-0.7-0.60.5
Short access total locomotion0.20.32.2-0.1-0.10.60.50.4-1.5-0.9-0.4-0.1-0.9-0.20.20.3-0.2
One hour access (0.3 mA shock)0.30.31.0-0.3-0.31.0-0.30.7-0.7-0.6-0.5-0.4-0.2-1.00.40.4-0.3
Compulsive drug intake0.20.30.8-0.0-0.10.1-0.80.20.1-0.3-0.6-0.80.2-0.80.90.8-0.8
One hour access (shock baseline)0.10.41.5-0.5-0.60.90.20.6-1.2-0.9-0.5-0.3-0.9-0.30.00.10.0
Social response proportion2.43.05.2-1.3-1.31.6-1.31.3-2.3-2.1-1.9-1.8-1.6-1.71.91.9-2.0
Social responses0.10.10.4-0.10.10.5-0.10.5-0.6-0.1-0.00.0-0.4-0.20.20.2-0.2
Social time0.71.22.8-0.5-0.70.8-0.50.8-1.7-1.5-1.4-0.9-1.0-0.71.21.3-1.3
Soleus weight0.72.23.2-1.1-1.21.2-1.31.3-1.8-1.8-1.7-1.5-1.2-1.21.61.7-1.7
Bone: stiffness0.00.10.20.20.40.1-0.1-0.2-0.10.30.50.1-0.2-0.30.1-0.10.1
Tibialis anterior weight0.61.94.9-1.8-1.91.7-0.41.8-2.2-1.8-1.5-0.7-0.5-0.41.10.9-0.9
Time to tail flick, vehicle, before self-admin0.20.30.90.40.4-0.8-0.6-0.40.90.1-0.2-0.9-0.50.10.70.4-0.3
Time to tail flick, vehicle, after self-admin0.61.23.61.11.3-1.21.2-1.90.81.01.30.90.21.1-0.9-0.90.9
Time to tail flick, test, before self-admin1.01.12.4-1.3-1.60.7-0.71.0-0.9-1.4-1.5-1.2-0.3-0.51.00.9-0.8
Time to tail flick, test, after self-admin0.00.00.10.0-0.0-0.10.4-0.20.0-0.1-0.00.10.10.3-0.1-0.10.1
Delta time to tail flick, vehicle, before/after SA1.51.63.21.21.2-0.71.8-1.60.41.01.41.60.91.1-1.4-1.31.3
Delta time to tail flick, test, before/after SA1.01.22.01.31.2-0.91.4-1.00.91.01.11.40.91.1-1.1-1.11.1
Tibia length0.72.010.1-0.9-0.00.5-2.00.3-1.2-0.3-0.1-1.6-3.2-1.51.41.4-1.4
Ambulatory time before self-admin0.10.40.80.90.7-0.80.6-0.00.80.60.40.70.90.5-0.7-0.50.4
Ambulatory time after self-admin0.00.10.30.00.10.00.10.40.00.40.40.60.4-0.0-0.1-0.0-0.0
Bone: tissue strength0.20.31.4-0.8-0.30.1-0.80.2-0.30.10.2-0.4-1.2-0.20.50.4-0.4
Total heroin consumption1.51.84.91.40.9-0.81.7-0.61.31.00.91.72.20.9-1.5-1.41.4
Bone: trabecular number2.24.19.12.93.0-2.51.5-2.72.02.42.31.60.81.4-1.1-1.21.2
Bone: trabecular spacing1.01.53.7-1.9-1.91.7-0.51.9-1.6-1.4-1.1-0.6-0.9-0.40.20.2-0.2
Bone: trabecular thickness0.40.62.01.31.4-1.0-0.1-1.40.30.30.4-0.4-0.5-0.40.60.6-0.6
Bone: trabecular tissue density0.10.30.70.40.6-0.7-0.4-0.90.70.60.4-0.3-0.70.1-0.10.2-0.2
Water consumed over 24 hours0.30.61.4-0.4-0.10.1-1.20.3-0.5-0.4-0.5-1.1-1.2-0.90.90.8-0.8
Number of responses in last shaping day0.20.32.00.50.7-0.20.1-0.2-0.7-0.20.1-0.4-1.4-0.30.20.1-0.1