Hub : Genes

Gnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Gnl1 0.61 0.24 8.3e-16 0.16 0.18 0.18 0.19 1.8e-14 3.1e-16 2.8e-16 3.4e-17
2 NAcc gene expression Gnl1 0.04 0.03 1.5e-03 0.01 0.02 0.02 0.02 2.1e-02 8.5e-04 1.1e-03 6.9e-04
3 Adipose gene expression Gnl1 0.06 0.04 2.5e-06 0.06 0.05 0.06 0.06 9.8e-07 1.7e-06 1.0e-06 6.2e-07
4 IC gene expression Gnl1 0.16 0.12 4.6e-04 0.04 0.08 0.05 0.05 8.6e-03 3.9e-04 4.7e-03 4.3e-03
5 Brain mRNA stability Gnl1 0.05 0.03 2.8e-04 0.02 0.04 0.02 0.03 7.6e-03 2.7e-04 3.0e-03 8.7e-04
6 Liver gene expression Gnl1 0.11 0.07 1.6e-10 0.07 0.08 0.08 0.07 4.5e-08 7.4e-09 2.4e-09 9.6e-09
7 PL gene expression Gnl1 0.1 0.05 5.7e-11 0.09 0.1 0.1 0.1 2.9e-10 6.4e-11 1.0e-10 1.6e-10
8 pVTA gene expression Gnl1 0.05 0.04 1.5e-03 0.03 0.03 0.02 0.02 2.4e-03 8.6e-04 8.1e-03 1.5e-02
9 BLA gene expression Gnl1 0.19 0.09 6.3e-09 0.1 0.11 0.1 0.1 7.0e-06 1.5e-06 3.6e-06 4.1e-06
10 IL gene expression Gnl1 0.91 0.04 3.0e-04 0.13 0.09 0.08 0.1 5.0e-04 3.2e-03 5.0e-03 2.3e-03
11 Adipose mRNA stability Gnl1 0.04 0.03 2.3e-03 0 0.02 0.02 0.02 1.1e-01 1.9e-03 8.9e-04 3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.23.90.91.1-1.71.5-0.60.50.00.2-0.2-0.82.0
Area under the delay curve0.91.03.70.50.20.4-0.0-0.7-1.61.10.91.21.9-0.7
BMI with tail1.65.58.62.22.3-1.11.6-2.6-2.92.92.72.82.61.1
BMI without tail2.16.413.21.81.8-0.11.1-2.5-3.63.23.03.33.50.6
Body weight1.87.922.5-0.3-0.13.3-1.7-1.1-4.42.92.53.64.7-1.2
Weight adjusted by age0.91.33.3-0.9-0.41.8-1.30.1-1.60.60.30.81.7-1.5
Bone surface0.10.30.6-0.8-0.70.7-0.60.50.1-0.3-0.3-0.20.1-0.6
Bone volume0.10.20.40.30.4-0.10.4-0.4-0.50.50.50.40.40.6
Breakpoint value in progressive ratio session0.20.20.50.10.0-0.0-0.30.50.6-0.6-0.6-0.7-0.7-0.1
Number of licking bursts1.22.04.4-1.3-1.70.9-1.31.41.3-1.4-1.5-1.3-1.0-2.1
Context. condit. distance diff. score6.88.314.4-2.8-2.71.0-1.73.13.8-3.5-3.3-3.5-3.4-0.7
Locomotion velocity, session 10.60.71.0-0.9-0.80.4-0.70.91.0-1.0-1.0-0.9-0.8-0.3
Locomotion distance, session 10.60.82.71.11.0-1.61.2-0.9-0.30.50.60.4-0.01.0
Locomotion velocity, session 20.20.20.3-0.5-0.40.4-0.50.50.3-0.4-0.5-0.4-0.3-0.3
Locomotion distance, session 20.10.10.60.20.2-0.80.3-0.10.3-0.2-0.1-0.2-0.40.6
Locomotion velocity, session 30.70.81.10.91.1-0.71.0-1.0-0.70.90.90.80.60.9
Locomotion distance, session 30.40.51.50.10.2-0.90.70.10.9-0.5-0.3-0.6-1.01.2
Stereotopy head waving bouts, day 31.11.23.5-1.2-1.21.9-1.60.8-0.4-0.2-0.40.10.6-1.8
Stereotopy head waving duration, day 30.60.72.2-0.7-0.81.4-1.20.5-0.50.0-0.20.20.6-1.5
Locomotion velocity, session 71.71.94.9-0.6-0.4-1.00.40.92.2-1.6-1.3-1.8-2.21.1
Locomotion distance, session 71.11.43.40.10.2-1.61.00.21.7-1.0-0.8-1.3-1.81.5
Stereotopy head waving bouts, day 70.91.02.5-0.1-0.01.4-0.7-0.3-1.51.00.81.21.6-1.0
Stereotopy head waving duration, day 70.81.02.5-0.1-0.01.4-0.7-0.3-1.51.00.81.21.6-0.9
Locomotion velocity, session 85.76.910.5-3.1-3.22.6-3.02.92.0-2.5-2.6-2.2-1.4-2.6
Locomotion distance, session 83.34.88.8-2.1-2.00.6-1.22.33.0-2.7-2.6-2.7-2.7-0.2
Degree of sensitization distance1.21.21.5-1.2-1.20.6-0.91.21.2-1.2-1.2-1.1-0.9-1.2
Degree of sensitization stereotypy0.50.51.20.20.30.7-0.2-0.5-1.10.80.70.91.1-0.5
Conditioned locomotion0.30.30.9-0.4-0.40.8-0.90.3-0.40.0-0.10.20.5-0.9
Cocaine response after cond. corrected0.10.20.50.10.1-0.60.30.10.6-0.4-0.3-0.5-0.70.1
Cocaine response after cond. not corrected0.50.51.0-0.9-0.90.8-1.00.80.4-0.6-0.7-0.5-0.2-1.0
Cocaine response before conditioning1.51.85.4-1.2-1.22.3-2.00.7-1.10.30.10.71.6-1.6
Saline control response2.93.85.41.82.0-1.01.5-2.1-2.32.32.22.22.01.6
Bone: connectivity density0.81.23.1-0.10.0-1.20.70.41.6-1.1-0.9-1.3-1.81.2
Bone: cortical apparent density1.82.54.01.92.0-0.71.5-1.8-1.51.61.71.51.21.6
Bone: cortical area0.50.82.30.10.10.9-0.4-0.4-1.40.90.81.11.5-0.5
Bone: cortical porosity0.30.30.70.30.1-0.10.0-0.5-0.90.70.60.80.8-0.7
Bone: cortical porosity0.30.31.7-0.5-0.70.4-0.70.2-0.40.1-0.00.20.5-1.3
Bone: cortical thickness4.47.310.82.72.8-0.81.9-2.9-3.33.23.23.23.01.4
Bone: cortical thickness3.84.56.22.32.5-1.42.0-2.4-2.02.32.32.11.71.7
Bone: cortical tissue density1.52.03.41.71.9-0.61.4-1.6-1.31.51.51.31.01.4
Condit. Reinf. active minus inactive responses0.30.30.9-0.2-0.1-0.30.00.40.8-0.7-0.6-0.8-1.00.3
Condit. Reinf. active-inactive response ratio0.20.20.50.60.7-0.30.5-0.6-0.50.50.50.40.30.1
Condit. Reinf. active responses0.40.51.3-0.10.2-0.70.40.31.0-0.7-0.6-0.9-1.21.1
Condit. Reinf. inactive responses1.01.35.60.70.8-1.71.3-0.30.9-0.3-0.1-0.6-1.12.4
Incentive salience index mean1.82.23.5-1.4-1.30.5-1.01.61.9-1.8-1.7-1.8-1.8-0.4
Condit. Reinf. lever presses3.95.58.3-2.4-2.31.0-1.62.62.9-2.8-2.7-2.8-2.6-0.6
Condit. Reinf. active minus inactive responses0.40.52.2-0.4-0.50.7-0.80.1-0.60.30.10.50.9-1.5
Condit. Reinf. active-inactive response ratio1.01.25.1-0.8-0.91.5-1.40.5-0.80.2-0.00.51.1-2.3
Condit. Reinf. active responses0.10.10.3-0.4-0.3-0.1-0.20.30.3-0.4-0.3-0.3-0.2-0.5
Condit. Reinf. inactive responses0.50.71.80.00.2-1.10.70.11.1-0.6-0.5-0.8-1.21.4
Condit. Reinf. lever presses0.40.51.2-0.5-0.5-0.4-0.00.61.1-0.9-0.8-0.9-1.1-0.1
Condit. Reinf. lever reinforcers received0.20.30.4-0.6-0.5-0.0-0.40.50.5-0.6-0.6-0.5-0.4-0.6
Conditioned reinforcement - actives0.71.22.21.30.9-0.20.7-1.1-1.41.41.31.51.00.5
Conditioned reinforcement - inactives1.01.52.71.21.0-0.60.9-1.3-1.51.51.41.61.30.3
Conditioned locomotion0.00.00.2-0.0-0.40.2-0.20.1-0.10.10.10.30.1-0.1
Patch foraging indifference point 0 sec1.62.94.52.12.0-1.41.7-1.9-1.61.81.81.61.21.4
Patch foraging indifference point AUC0.40.51.8-0.5-0.40.7-0.3-0.3-0.90.70.60.91.3-0.7
Delay disc. indifference point, 0s delay0.40.41.2-0.6-0.80.8-0.80.4-0.5-0.0-0.20.10.8-1.1
Delay disc. indifference point, 16s delay3.53.85.42.11.9-1.11.6-2.2-2.32.22.22.22.30.5
Delay disc. indifference point, 2s delay0.80.93.7-0.4-0.71.1-1.00.1-1.10.40.20.61.4-1.9
Delay disc. indifference point, 24s delay0.60.71.31.00.9-0.30.6-0.8-0.90.90.90.91.1-0.3
Delay disc. indifference point, 4s delay1.01.13.2-0.4-0.61.5-1.10.1-1.40.60.40.91.8-1.2
Delay disc. indifference point, 8s delay0.30.31.30.40.2-0.10.2-0.4-0.80.50.50.61.1-0.2
Indifference point function ln k0.50.81.2-0.6-0.80.4-0.81.01.0-1.1-1.1-1.0-1.0-0.8
Indifference point function log k0.50.81.2-0.6-0.80.4-0.81.01.0-1.1-1.1-1.0-1.0-0.8
Patch foraging total patch changes 0 sec1.93.75.42.32.1-1.51.9-2.2-1.82.12.11.91.51.4
Patch foraging total patch changes 12 sec2.22.94.01.61.5-1.41.7-2.0-1.82.02.01.91.60.8
Patch foraging total patch changes 18 sec3.04.67.02.22.3-2.22.6-2.5-1.52.12.31.91.32.2
Patch foraging total patch changes 24 sec2.54.37.62.42.5-2.62.8-2.3-1.01.71.91.40.62.5
Patch foraging total patch changes 6 sec3.04.56.32.22.2-1.92.3-2.5-2.02.32.32.11.61.7
Patch foraging time to switch 0 sec0.40.91.81.11.1-1.31.3-1.0-0.30.70.80.5-0.01.3
Patch foraging water rate 0 sec0.20.51.10.60.5-0.20.1-0.7-1.00.80.70.91.0-0.7
Patch foraging water rate 12 sec0.40.81.81.11.3-1.01.0-1.0-0.60.80.80.70.30.9
Patch foraging water rate 18 sec0.00.10.20.00.20.4-0.30.0-0.50.20.10.30.40.2
Patch foraging water rate 24 sec0.81.22.60.60.80.30.2-1.0-1.51.31.31.51.60.2
Patch foraging water rate 6 sec0.50.71.11.01.0-0.91.0-1.0-0.70.80.90.80.60.5
Seeking ratio, delayed vs. immediate footshock0.10.20.40.30.60.6-0.50.0-0.60.30.20.30.4-0.1
Distance traveled before self-admin0.81.12.5-1.5-1.61.5-1.31.20.4-0.8-0.8-0.6-0.1-0.5
Distance traveled after self-admin0.50.62.7-0.9-0.81.6-1.20.6-0.40.0-0.20.10.2-1.0
Extensor digitorum longus weight0.20.81.5-1.1-1.21.0-0.91.10.6-0.8-0.8-0.7-0.4-0.7
Bone: elastic displacement0.91.01.31.21.1-0.90.8-1.1-1.11.11.11.00.80.7
Bone: elastic work1.21.63.70.90.80.00.2-1.1-1.91.61.41.71.9-0.3
Bone: endosteal estimation3.88.315.6-3.6-3.83.6-4.03.10.8-1.9-2.2-1.30.0-3.8
Bone: endosteal perimeter4.39.114.9-3.8-3.92.6-3.43.52.3-2.9-3.1-2.5-1.7-2.9
Epididymis fat weight10.837.151.87.27.2-5.56.3-7.1-5.36.46.55.84.14.9
Delta time in closed arm before/after self-admin0.20.20.4-0.1-0.0-0.10.1-0.4-0.60.50.50.60.5-0.6
Delta time in open arm before/after self-admin0.20.20.60.0-0.10.8-0.30.1-0.40.10.20.30.70.8
Diff in mean of infusions in LGA sessions1.21.53.61.10.4-1.91.00.31.7-1.1-0.9-1.3-1.90.8
Delay discount exponential model param0.91.03.9-0.5-0.2-0.40.10.71.5-1.0-0.9-1.2-2.00.7
Extinction: sum of active levers before priming0.20.30.90.1-0.2-0.2-0.20.40.6-0.6-0.7-0.8-0.1-0.9
Active lever presses in extinction session 60.80.81.41.11.1-1.21.1-0.9-0.50.70.70.50.30.8
Bone: final force3.15.010.81.61.50.30.6-2.1-3.32.82.63.03.30.1
Bone: final moment2.64.29.41.41.30.30.5-1.9-3.02.62.42.83.10.2
Food consumed during 24 hour testing period0.50.72.7-1.1-0.91.6-1.20.8-0.1-0.4-0.4-0.10.3-0.3
Glucose6.710.514.5-3.8-3.82.8-3.43.73.0-3.5-3.5-3.1-2.4-2.2
Heart weight0.91.43.11.20.50.5-0.1-0.7-1.51.31.11.41.8-1.6
Delay discount hyperbolic model param0.91.03.9-0.4-0.2-0.40.10.71.6-1.1-0.9-1.2-2.00.9
Intermittent access intake day 1-15 change0.00.10.2-0.40.1-0.1-0.10.20.3-0.2-0.2-0.2-0.40.3
Intermittent access intake escalation0.10.21.00.10.7-0.30.3-0.4-0.30.40.40.40.11.0
Intermittent access intake escalation 20.70.72.2-1.5-0.61.0-1.11.00.6-0.8-0.8-0.7-0.6-0.1
Intermitt. access day 1 inactive lever presses0.31.34.8-1.3-1.31.1-1.41.00.6-0.7-0.9-0.5-0.4-2.2
Intermitt. access day 15 inactive lever presses0.20.30.8-0.4-0.20.4-0.4-0.2-0.80.60.50.80.9-0.7
Intermitt. access escalation Index1.21.74.1-0.6-1.0-0.4-0.21.22.0-1.8-1.6-1.8-1.50.1
Intermittent access day 1 total infusions0.50.83.71.91.0-0.81.0-0.7-0.40.50.60.40.31.1
Intermittent access day 15 total infusions0.50.81.91.41.1-0.50.8-0.8-0.70.80.80.70.41.4
Intermittent access terminal intake (last 3 days)0.81.02.21.51.2-0.50.9-1.0-1.01.11.01.00.80.8
Intermittent access total infusions0.70.82.31.50.9-0.30.8-0.8-0.80.80.80.81.01.1
Intermittent access day 1 locomotion0.10.10.90.50.10.1-0.00.20.0-0.2-0.1-0.2-0.00.9
Intermittent access day 15 total locomotion0.20.31.4-0.1-0.41.2-0.60.1-0.70.40.30.70.60.3
Intermittent access total locomotion0.40.41.00.40.11.0-0.4-0.0-0.90.50.50.71.00.8
Intermittent access standard deviation1.22.44.61.31.4-0.40.7-1.6-2.12.01.82.01.90.6
Left kidney weight1.67.520.41.11.12.0-0.5-1.8-4.43.32.93.74.5-0.3
Right kidney weight1.67.219.40.60.82.8-1.1-1.4-4.43.02.63.54.4-0.5
Cocaine induced anxiety0.91.32.2-1.0-1.20.5-1.01.41.3-1.5-1.4-1.4-0.9-0.5
Post-drug Anxiety0.40.40.9-0.6-0.4-0.1-0.40.60.7-0.9-0.8-0.9-0.5-0.6
Baseline Anxiety0.70.82.31.01.2-1.51.2-1.1-0.50.70.60.30.1-0.3
Tail length1.87.125.3-2.8-2.95.0-3.81.8-1.70.1-0.30.82.5-3.0
Length with tail2.410.438.6-3.4-3.36.2-4.72.1-2.20.2-0.31.13.1-3.3
Length without tail1.65.218.0-1.8-1.74.2-3.00.8-2.40.90.51.52.8-2.5
Times rat made contact with spout1.72.04.91.61.7-2.12.0-1.3-0.20.80.90.4-0.22.2
Lifetime Intake0.70.92.01.40.7-0.10.6-0.8-1.10.90.91.01.20.9
Liver weight, left3.05.09.2-2.8-2.83.0-3.02.61.0-1.8-2.0-1.5-0.6-1.9
Liver weight, right2.74.812.8-2.6-2.83.6-3.22.20.0-1.1-1.4-0.60.4-2.5
Locomotor activity2.84.411.6-3.4-2.92.7-2.72.20.9-1.5-1.6-1.1-0.3-1.5
Locomotor testing distance1.11.95.4-2.3-2.11.4-1.51.40.9-1.1-1.1-0.9-0.4-1.1
Locomotor testing rearing0.61.22.9-1.7-1.61.4-1.41.10.2-0.7-0.7-0.50.1-0.9
Locomotion in novel chamber0.40.51.8-0.6-0.50.6-0.0-0.3-0.90.60.60.71.30.2
Locomotion in novel chamber post-restriction0.50.92.30.10.70.10.3-1.0-1.51.21.01.21.2-0.2
Fecal boli incidents, locomotor time 10.20.30.80.90.3-0.60.30.20.9-0.4-0.3-0.6-0.70.7
Change in fecal boli incidents, locomotor task0.50.54.1-0.1-0.30.7-0.60.0-0.40.20.10.40.4-2.0
Time >=10cm from walls, locomotor time 11.01.12.8-1.0-1.21.7-1.51.00.3-0.6-0.7-0.4-0.3-1.4
Bouts of movement, locomotor time 10.91.01.9-1.4-1.10.5-0.71.11.0-1.3-1.2-1.3-0.60.3
Total resting periods, locomotor time 10.80.91.3-1.2-1.10.8-0.91.10.8-1.1-1.1-1.1-0.60.1
Rest time, locomotor task time 10.91.23.0-1.7-1.31.5-1.41.10.5-0.8-0.9-0.7-0.4-0.6
Distance moved, locomotor task time 10.50.81.31.10.9-0.50.8-1.0-1.01.11.01.10.6-0.1
Vertical activity count, locomotor time 10.30.60.90.90.9-0.50.7-0.9-0.80.90.90.90.60.3
Time >=10cm from walls, locomotor time 20.50.72.4-0.3-0.71.0-1.10.90.6-0.7-0.8-0.6-0.5-1.5
Bouts of movement, locomotor time 21.11.85.1-2.3-1.61.9-1.91.40.4-0.9-1.0-0.7-0.3-0.4
Total resting periods, locomotor time 21.72.97.9-2.8-2.22.1-2.21.80.8-1.4-1.5-1.1-0.5-0.7
Rest time, locomotor task time 24.05.18.7-2.9-2.52.4-2.62.71.8-2.3-2.4-2.1-1.2-1.3
Distance moved, locomotor task time 22.32.84.11.91.6-1.31.6-2.0-1.82.01.91.91.20.5
Vertical activity count, locomotor time 20.71.02.21.51.3-1.01.1-1.2-0.70.91.00.80.40.2
Light reinforcement 10.30.71.11.10.9-0.60.9-1.0-0.60.90.90.80.50.4
Light reinforcement 20.20.42.1-0.3-0.31.5-1.00.4-0.40.0-0.10.20.5-0.3
Bone: marrow area3.78.015.1-3.6-3.83.6-3.93.00.7-1.9-2.1-1.30.0-3.7
Bone: maximum diameter1.93.66.4-2.4-2.52.0-2.42.11.0-1.6-1.7-1.2-0.5-2.4
Bone: maximum force1.93.38.31.01.00.70.1-1.5-2.82.32.12.52.9-0.2
Bone: maximum moment1.52.67.00.70.70.8-0.1-1.2-2.62.01.82.22.7-0.2
Mean time between licks in bursts2.15.27.1-2.7-2.62.5-2.52.61.8-2.3-2.3-2.0-1.4-1.8
Mean num. licks in bursts2.43.79.32.02.3-1.92.1-1.9-1.31.61.81.40.83.1
Cd content in liver0.60.71.71.01.0-1.30.8-0.8-0.50.60.50.40.01.2
Co content in liver2.02.43.21.71.5-1.41.4-1.8-1.71.71.71.61.40.5
Cu content in liver1.82.16.01.61.7-2.42.1-1.20.20.50.70.1-0.62.1
Fe content in liver1.51.82.21.51.4-1.01.1-1.5-1.51.51.51.41.21.1
K content in liver0.20.20.70.50.6-0.50.9-0.50.10.30.40.20.10.5
Mg content in liver1.41.42.4-1.1-1.20.3-0.61.21.5-1.4-1.3-1.4-1.2-1.1
Mn content in liver5.86.48.6-2.9-2.91.5-2.12.82.9-2.9-2.8-2.7-2.2-1.7
Na content in liver1.51.62.31.51.3-1.11.3-1.5-1.21.41.41.31.20.4
Rb content in liver0.30.41.1-0.0-0.1-1.10.60.20.9-0.6-0.4-0.7-0.90.6
Se content in liver3.84.56.9-2.4-2.61.6-2.32.41.8-2.2-2.3-2.0-1.3-2.1
Sr content in liver0.40.40.8-0.7-0.90.8-0.90.5-0.1-0.2-0.3-0.00.3-0.9
Zn content in liver0.10.20.4-0.5-0.60.0-0.30.50.4-0.5-0.4-0.4-0.4-0.1
Bone: minimum diameter2.64.78.3-2.9-2.92.6-2.82.41.1-1.8-1.9-1.4-0.5-2.2
Time in familiar zone, hab. session 12.12.15.91.61.8-2.12.0-1.20.30.40.6-0.0-0.82.4
Time in novel zone, hab. session 11.51.53.2-1.5-1.71.7-1.71.20.1-0.6-0.7-0.30.3-1.8
Total zone transitions, hab. session 10.20.20.6-0.1-0.0-0.60.40.10.8-0.5-0.4-0.6-0.80.5
Total locomotion distance, hab. session 10.10.20.50.20.3-0.70.5-0.10.4-0.2-0.1-0.3-0.60.5
Locomotion velocity, hab. session 10.10.20.50.50.5-0.70.6-0.40.00.20.20.1-0.20.4
Time in familiar zone, hab. session 20.50.52.20.70.8-0.80.9-0.6-0.20.40.50.2-0.11.5
Time in novel zone, hab. session 20.10.10.5-0.2-0.10.4-0.30.1-0.30.10.10.20.4-0.7
Total zone transitions, hab. session 20.20.20.80.50.4-0.90.4-0.5-0.30.40.40.30.2-0.2
Total locomotion distance, hab. session 20.30.42.00.40.4-1.40.7-0.20.6-0.3-0.2-0.4-0.80.4
Locomotion velocity, hab. session 20.30.41.80.30.2-1.30.6-0.10.7-0.4-0.3-0.6-0.90.1
Novel to familiar place preference ratio0.20.20.30.60.5-0.50.6-0.5-0.30.50.50.40.3-0.0
Novelty place preference0.10.20.20.40.3-0.20.4-0.4-0.40.50.50.50.4-0.3
Time in novel zone, NPP test0.10.10.30.30.20.00.2-0.4-0.40.50.40.50.5-0.4
Total zone transitions, NPP test0.30.51.3-0.2-0.2-0.80.30.31.1-0.8-0.7-0.9-1.10.4
Total locomotion distance, NPP test0.40.51.80.60.7-1.30.9-0.40.5-0.1-0.0-0.3-0.80.9
Locomotion velocity, NPP test0.60.82.70.70.7-1.71.1-0.30.8-0.3-0.1-0.5-1.11.1
Intraocular pressure0.30.52.40.10.2-0.60.40.20.8-0.5-0.3-0.6-0.91.5
Delta distance traveled before/after self-admin0.80.92.00.80.80.40.1-0.8-1.41.21.01.31.1-0.6
Delta ambulatory time before/after self-admin0.30.40.80.30.30.7-0.3-0.3-0.90.70.60.80.7-0.9
Parametrial fat weight0.61.33.30.20.50.50.2-0.8-1.81.41.31.51.61.4
Pavlov. Cond. lever latency4.15.27.42.72.6-2.02.3-2.6-2.22.52.42.21.71.6
Pavlov. Cond. magazine entry latency3.94.96.6-2.5-2.41.5-2.02.52.4-2.6-2.5-2.4-2.0-1.1
Pavlov. Cond. change in total contacts1.61.73.8-1.6-1.61.9-1.71.50.6-1.0-1.1-0.8-0.2-1.3
Pavlov. Cond. index score5.36.68.9-3.0-2.81.9-2.43.02.6-2.9-2.9-2.7-2.2-1.5
Pavlov. Cond. latency score4.96.28.7-2.9-2.82.1-2.52.92.4-2.7-2.7-2.5-1.9-1.7
Pavlov. Cond. lever contacts4.25.07.1-2.7-2.62.1-2.32.62.0-2.4-2.4-2.1-1.5-1.7
Pavlov. Cond. magazine entry number3.64.56.42.22.1-1.01.6-2.3-2.52.52.52.52.20.9
Pavlov. Cond. intertrial magazine entries2.42.85.22.02.2-2.12.1-1.7-0.81.31.41.00.32.3
Pavlov. Cond. lever-magazine prob. diff.5.16.38.4-2.9-2.71.7-2.32.92.7-2.9-2.8-2.7-2.2-1.3
Pavlov. Cond. response bias4.96.08.2-2.8-2.61.6-2.12.82.7-2.9-2.8-2.7-2.3-1.1
Pavlov. Cond. lever latency0.10.20.4-0.3-0.50.6-0.50.3-0.20.0-0.00.20.4-0.6
Pavlov. Cond. magazine entry latency0.30.41.5-0.6-0.61.2-0.80.4-0.2-0.1-0.20.00.3-0.9
Pavlov. Cond. change in total contacts0.10.20.40.30.2-0.10.2-0.5-0.50.50.50.50.6-0.6
Pavlov. Cond. index score0.10.10.4-0.3-0.30.6-0.30.20.1-0.2-0.2-0.2-0.1-0.4
Pavlov. Cond. latency score0.00.00.2-0.1-0.00.5-0.1-0.0-0.20.10.10.10.2-0.4
Pavlov. Cond. lever contacts0.10.10.20.30.4-0.40.4-0.30.10.10.1-0.0-0.20.4
Pavlov. Cond. magazine entry number0.10.20.60.20.2-0.80.40.00.4-0.2-0.1-0.3-0.50.5
Pavlov. Cond. intertrial magazine entries1.62.43.6-1.4-1.50.4-1.11.81.9-1.9-1.8-1.9-1.8-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.3-0.20.6-0.30.20.1-0.2-0.2-0.2-0.1-0.4
Pavlov. Cond. response bias0.10.20.3-0.5-0.30.3-0.30.40.5-0.5-0.5-0.5-0.5-0.1
Time in closed arm before self-admin0.10.10.50.10.2-0.2-0.10.20.1-0.2-0.3-0.3-0.2-0.7
Time in closed arm after self-admin1.01.01.60.80.6-0.70.9-1.2-1.21.21.21.31.1-0.3
Time in open arm before self-admin0.40.50.7-0.7-0.60.2-0.50.80.8-0.8-0.8-0.9-0.8-0.0
Time in open arm after self-admin0.60.71.2-0.8-0.80.9-0.91.10.7-1.0-1.0-0.9-0.40.3
Bone: periosteal estimation1.53.27.5-2.1-2.22.7-2.61.6-0.4-0.5-0.8-0.10.9-2.6
Bone: periosteal perimeter1.42.44.7-2.0-2.02.1-2.21.70.4-1.0-1.2-0.70.0-2.0
Bone: post-yield work3.04.47.1-2.7-2.52.0-2.22.51.8-2.2-2.2-1.9-1.3-1.2
Progressive ratio test 1 active lever presses0.60.83.81.91.0-0.40.8-0.8-0.80.70.70.70.60.3
Progressive ratio test 1 breakpoint0.70.83.71.91.0-0.40.7-0.8-0.80.80.70.70.70.2
Progressive ratio test 1 inactive lever presses1.31.93.92.01.7-1.51.7-1.6-0.91.41.41.20.40.8
Progressive ratio test 2 active lever presses0.60.72.31.51.1-0.91.0-0.7-0.30.40.50.30.21.0
Progressive ratio test 2 breakpoint0.70.82.41.61.1-1.01.0-0.7-0.40.50.60.40.31.1
Progressive ratio test 2 inactive lever presses0.10.10.40.7-0.00.0-0.1-0.1-0.50.30.20.50.4-0.4
Incentive Sensitization - Responses0.10.20.60.30.4-0.80.40.10.6-0.3-0.3-0.5-0.50.4
Incentive Sensitization - Breakpoint0.20.20.80.30.5-0.90.50.00.6-0.3-0.3-0.4-0.50.7
Sum of active levers in priming session hrs 5-60.30.30.6-0.20.1-0.2-0.40.40.4-0.6-0.7-0.8-0.7-0.5
Progressive ratio2.03.28.80.90.60.70.1-1.5-3.02.32.12.52.50.0
Food seeking constrained by brief footshock0.00.10.3-0.10.1-0.30.3-0.1-0.10.00.1-0.00.10.6
Seeking ratio, punishment vs. effort1.82.57.3-0.8-0.5-0.90.11.22.7-2.0-1.8-2.2-2.3-0.1
Retroperitoneal fat weight0.21.02.50.30.40.50.1-0.8-1.61.21.11.31.31.0
Reaction time number correct1.22.33.31.71.8-1.51.7-1.8-1.21.61.61.41.11.1
Reaction time mean minus median2.97.113.9-3.7-3.23.0-3.13.21.9-2.7-2.6-2.4-1.5-0.3
Reaction time mean minus median AUC2.05.110.4-3.2-2.72.3-2.52.61.7-2.3-2.3-2.1-1.4-0.2
Reaction time num false alarms0.20.31.5-0.6-0.60.9-0.70.2-0.30.0-0.10.20.4-1.2
Reaction time num false alarms AUC0.30.52.6-0.4-0.61.1-0.80.2-0.40.1-0.00.30.6-1.6
Reaction time trials correct on left1.22.33.31.71.8-1.51.7-1.8-1.21.61.61.41.11.1
Reaction time trials on left1.12.13.01.61.7-1.41.6-1.7-1.21.51.61.41.11.0
Reaction time mean4.87.712.5-3.5-3.32.7-2.93.22.4-2.9-2.9-2.6-1.9-1.4
Reaction time mean AUC4.87.712.7-3.6-3.32.8-3.03.22.4-2.9-2.9-2.6-2.0-1.2
Median of all reaction times3.55.07.6-2.7-2.72.2-2.32.52.1-2.3-2.3-2.1-1.6-1.5
Reaction time omissions3.24.66.9-2.5-2.52.2-2.52.61.6-2.3-2.3-2.0-1.4-0.9
Reaction time false alarm rate1.21.74.5-1.3-1.61.8-1.71.20.4-0.8-1.0-0.6-0.1-2.1
Reaction time premature initiation rate0.70.92.10.70.40.8-0.0-0.7-1.31.11.01.31.5-0.8
Reaction time premature initiations1.52.64.31.61.5-0.10.9-1.8-2.02.01.92.02.1-0.3
Std. dev. reaction times4.38.014.1-3.8-3.53.2-3.43.31.9-2.7-2.8-2.4-1.5-1.3
Reaction time trials completed1.12.13.01.61.7-1.41.6-1.7-1.21.51.61.41.11.0
Reaction time trials AUC1.12.12.91.61.7-1.51.6-1.7-1.11.51.51.31.01.0
Run reversals in cocaine runway, females1.01.01.91.41.1-1.01.1-1.1-1.01.00.90.80.90.8
Run reversals in cocaine runway, males2.32.36.6-1.9-2.02.6-2.21.70.3-1.0-1.1-0.70.4-0.6
Latency to leave start box in cocaine runway0.20.20.70.1-0.2-0.20.00.20.8-0.4-0.3-0.3-0.8-0.8
Latency to leave start box in cocaine runway, F0.40.41.3-0.4-0.4-0.1-0.00.41.1-0.8-0.6-0.7-1.0-0.5
Latency to leave start box in cocaine runway, M0.20.20.50.40.10.10.1-0.4-0.50.60.50.70.3-0.6
Std. dev. time between licks in bursts3.95.39.4-2.5-2.72.3-2.62.51.6-2.1-2.2-1.8-1.1-3.1
Total sessions with >9 infusions0.50.61.10.70.3-0.10.5-0.7-1.00.90.80.91.00.6
Short access day 1 total inactive lever presses0.91.14.6-1.0-1.32.1-1.50.7-0.5-0.0-0.10.41.1-1.1
Short access day 10 total inactive lever presses0.10.31.0-0.1-0.2-0.50.00.41.0-0.5-0.5-0.5-0.80.0
Short access day 1 total infusions0.10.10.60.3-0.3-0.20.2-0.2-0.40.20.20.20.70.2
Short access day 10 total infusions0.60.71.10.90.6-0.20.8-0.8-1.00.90.90.90.81.0
Short access total infusions0.70.91.71.30.5-0.20.7-0.9-1.21.01.01.11.30.6
Short access day 1 locomotion0.40.51.1-0.1-0.4-0.90.40.31.0-0.7-0.6-0.8-1.00.6
Short access day 10 total locomotion0.51.02.5-1.5-1.31.2-1.20.90.1-0.5-0.7-0.30.0-1.6
Short access total locomotion0.10.20.7-0.3-0.80.3-0.40.40.1-0.3-0.4-0.20.1-0.6
One hour access (0.3 mA shock)0.50.61.41.20.8-0.80.50.20.8-0.6-0.6-0.8-1.10.7
Compulsive drug intake2.73.26.4-0.8-1.2-0.2-0.81.72.5-2.3-2.2-2.4-2.5-1.1
One hour access (shock baseline)0.81.22.61.41.4-0.10.6-0.8-1.31.01.01.01.11.6
Social response proportion0.60.72.0-1.0-1.20.8-1.00.70.3-0.5-0.7-0.4-0.2-1.4
Social responses0.20.21.8-0.2-0.40.3-0.50.1-0.40.1-0.00.20.4-1.3
Social time3.85.28.2-2.8-2.92.7-2.72.61.5-2.1-2.2-1.8-0.9-2.2
Soleus weight3.29.417.8-3.5-4.03.3-3.63.31.8-2.6-2.8-2.1-1.0-4.2
Bone: stiffness0.81.42.21.01.2-0.30.7-1.2-1.51.41.41.41.40.8
Tibialis anterior weight0.82.73.71.91.8-1.71.9-1.9-1.41.71.71.51.11.3
Time to tail flick, vehicle, before self-admin0.80.91.6-1.3-1.0-0.1-0.20.81.1-1.0-0.9-1.1-1.30.7
Time to tail flick, vehicle, after self-admin1.01.42.2-1.4-1.50.3-0.91.41.2-1.4-1.4-1.4-0.9-0.5
Time to tail flick, test, before self-admin0.10.10.9-0.10.0-0.30.30.00.1-0.0-0.0-0.1-0.20.9
Time to tail flick, test, after self-admin0.70.81.9-1.4-0.60.6-0.60.90.8-0.9-0.8-0.9-1.00.8
Delta time to tail flick, vehicle, before/after SA0.10.10.40.70.3-0.50.4-0.20.10.10.20.10.30.3
Delta time to tail flick, test, before/after SA0.10.10.40.00.5-0.60.4-0.20.3-0.10.0-0.2-0.60.5
Tibia length1.33.710.8-2.2-2.23.3-2.91.6-0.8-0.4-0.70.11.3-2.5
Ambulatory time before self-admin0.30.41.1-0.9-1.01.1-0.70.60.0-0.4-0.3-0.20.3-0.1
Ambulatory time after self-admin0.50.62.9-0.5-0.61.7-1.10.5-0.60.20.00.30.7-1.0
Bone: tissue strength1.91.94.80.70.60.60.1-1.1-2.11.71.61.92.2-0.0
Total heroin consumption0.20.20.5-0.3-0.30.7-0.70.60.4-0.4-0.5-0.4-0.5-0.4
Bone: trabecular number0.91.54.81.21.4-1.91.7-0.90.30.30.5-0.0-0.72.2
Bone: trabecular spacing1.11.53.6-0.7-1.01.9-1.50.4-1.20.50.30.91.6-1.9
Bone: trabecular thickness0.60.83.30.71.1-1.21.1-0.50.30.00.2-0.2-0.71.8
Bone: trabecular tissue density0.60.92.20.40.40.8-0.3-0.6-1.51.10.91.21.5-0.8
Water consumed over 24 hours0.10.10.5-0.5-0.40.4-0.30.30.2-0.3-0.3-0.2-0.1-0.7
Number of responses in last shaping day0.60.74.2-0.4-1.10.5-0.70.2-0.40.1-0.10.20.9-2.1