Gnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Gnl1 0.25 0.13 1.1e-16 0.16 0.18 0.18 0.18 1.4e-14 5.6e-17 1.1e-16 7.2e-17
2 Adipose gene expression Gnl1 0.07 0.05 7.7e-07 0.05 0.06 0.06 0.06 2.3e-06 5.6e-07 1.8e-07 3.6e-07
3 Liver gene expression Gnl1 0.12 0.08 6.2e-11 0.06 0.08 0.07 0.07 1.1e-07 5.2e-09 1.3e-08 2.4e-08
4 IL gene expression Gnl1 0.2 0.13 2.9e-03 0.03 0.06 0.03 0.04 6.9e-02 1.4e-02 7.1e-02 3.3e-02
5 PL gene expression Gnl1 0.1 0.05 9.0e-12 0.1 0.1 0.1 0.1 5.2e-11 6.0e-11 4.8e-11 3.5e-11
6 BLA gene expression Gnl1 0.23 0.12 4.0e-09 0.14 0.12 0.09 0.13 8.4e-08 5.3e-07 1.8e-05 2.0e-07
7 Adipose mRNA stability Gnl1 0.04 0.03 1.7e-03 0.02 0.02 0.04 0.03 6.3e-03 2.6e-03 5.6e-05 2.9e-04
8 Brain mRNA stability Gnl1 0.05 0.04 4.9e-04 0.02 0.03 0.03 0.03 3.7e-03 8.1e-04 9.9e-04 5.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.14.41.42.1-0.5-0.7-0.70.9-0.80.0
Area under the delay curve1.21.32.40.4-1.0-1.11.51.4-1.31.40.0
BMI with tail1.13.57.30.6-1.8-1.82.72.6-2.7-0.30.0
BMI without tail1.53.16.5-0.3-2.6-1.02.42.3-2.40.30.0
Body weight2.711.329.6-1.4-5.4-1.34.24.2-4.60.80.0
Weight adjusted by age1.21.43.6-0.9-1.9-0.11.31.5-1.50.50.0
Bone surface0.10.20.7-0.7-0.70.40.00.0-0.10.90.0
Bone volume0.10.10.20.40.0-0.50.50.5-0.40.20.0
Breakpoint value in progressive ratio session0.60.71.5-0.01.10.5-1.0-1.01.20.50.0
Number of licking bursts0.70.81.7-1.2-0.21.3-1.1-1.01.00.30.0
Context. condit. distance diff. score5.56.612.6-2.11.03.2-3.5-3.63.5-0.50.0
Locomotion velocity, session 10.30.40.7-0.7-0.10.8-0.7-0.70.70.40.0
Locomotion distance, session 10.50.61.61.31.2-0.80.10.10.0-1.10.0
Locomotion velocity, session 20.10.10.3-0.6-0.30.5-0.3-0.30.3-0.30.0
Locomotion distance, session 20.20.31.10.40.7-0.0-0.4-0.40.5-1.00.0
Locomotion velocity, session 30.60.72.91.00.4-0.90.70.6-0.6-1.70.0
Locomotion distance, session 31.01.13.20.51.40.3-1.0-1.11.1-1.80.0
Stereotopy head waving bouts, day 30.91.13.9-1.5-2.00.60.50.5-0.80.90.0
Stereotopy head waving duration, day 30.70.82.5-1.1-1.60.40.60.6-0.81.20.0
Locomotion velocity, session 72.52.84.80.11.91.0-2.0-2.12.2-2.00.0
Locomotion distance, session 72.22.85.80.72.40.4-1.7-1.81.9-2.30.0
Stereotopy head waving bouts, day 71.01.12.2-0.2-1.5-0.51.31.4-1.40.70.0
Stereotopy head waving duration, day 71.21.53.6-0.5-1.9-0.41.51.5-1.60.90.0
Locomotion velocity, session 82.93.48.7-3.0-1.62.8-1.7-1.71.40.90.0
Locomotion distance, session 82.94.27.9-1.41.02.4-2.8-2.82.8-1.30.0
Degree of sensitization distance0.70.71.1-1.0-0.01.1-1.0-0.91.00.80.0
Degree of sensitization stereotypy0.60.71.4-0.0-1.1-0.61.11.2-1.20.50.0
Conditioned locomotion0.30.31.4-0.7-1.20.30.40.3-0.5-0.10.0
Cocaine response after cond. corrected0.20.20.70.30.90.1-0.5-0.50.60.30.0
Cocaine response after cond. not corrected0.50.51.9-1.0-0.80.7-0.2-0.30.11.40.0
Cocaine response before conditioning2.32.89.9-1.9-3.20.61.21.2-1.41.90.0
Saline control response1.62.03.51.5-0.1-1.91.91.9-1.7-0.80.0
Bone: connectivity density1.21.84.20.42.00.7-1.7-1.81.9-0.20.0
Bone: cortical apparent density1.52.04.11.90.4-2.01.61.6-1.4-1.00.0
Bone: cortical area1.11.63.4-0.1-1.8-0.81.71.7-1.8-0.10.0
Bone: cortical porosity0.50.51.00.6-0.2-0.91.01.0-1.00.20.0
Bone: cortical porosity0.30.30.9-0.5-1.00.00.50.5-0.60.60.0
Bone: cortical thickness3.96.411.12.4-0.7-3.23.33.3-3.2-1.60.0
Bone: cortical thickness2.42.85.32.20.6-2.31.81.8-1.6-1.70.0
Bone: cortical tissue density1.21.63.31.70.3-1.81.41.4-1.2-0.80.0
Condit. Reinf. active minus inactive responses0.40.40.9-0.00.70.5-0.9-1.00.9-0.20.0
Condit. Reinf. active-inactive response ratio0.10.10.30.60.3-0.60.30.4-0.30.10.0
Condit. Reinf. active responses0.60.81.40.31.20.4-1.1-1.21.1-0.80.0
Condit. Reinf. inactive responses1.21.53.71.11.9-0.2-0.9-1.11.1-1.90.0
Incentive salience index mean1.51.83.5-1.10.41.7-1.8-1.91.80.20.0
Condit. Reinf. lever presses2.73.66.9-1.60.52.4-2.6-2.62.50.60.0
Condit. Reinf. active minus inactive responses0.50.61.6-0.5-1.3-0.20.90.9-1.00.50.0
Condit. Reinf. active-inactive response ratio1.11.23.8-1.1-2.00.11.01.0-1.21.00.0
Condit. Reinf. active responses0.00.00.0-0.2-0.00.1-0.1-0.10.1-0.10.0
Condit. Reinf. inactive responses0.70.82.10.41.40.3-1.1-1.11.2-0.70.0
Condit. Reinf. lever presses0.20.30.70.10.80.2-0.6-0.60.7-0.30.0
Condit. Reinf. lever reinforcers received0.00.10.1-0.30.10.3-0.3-0.30.30.00.0
Conditioned reinforcement - actives0.30.30.70.2-0.2-0.40.60.7-0.70.80.0
Conditioned reinforcement - inactives1.01.12.21.0-0.4-1.31.41.5-1.30.30.0
Conditioned locomotion0.10.10.7-0.3-0.20.3-0.1-0.0-0.00.80.0
Patch foraging indifference point 0 sec1.21.93.81.90.5-1.91.51.4-1.3-1.30.0
Patch foraging indifference point AUC0.91.02.5-0.4-1.6-0.51.41.2-1.5-0.10.0
Delay disc. indifference point, 0s delay0.60.73.8-0.6-0.90.20.20.1-0.42.00.0
Delay disc. indifference point, 16s delay2.22.25.11.90.4-2.21.91.7-1.6-0.10.0
Delay disc. indifference point, 2s delay1.51.75.2-0.7-2.0-0.11.01.2-1.12.30.0
Delay disc. indifference point, 24s delay0.50.51.00.6-0.1-1.01.00.9-0.70.40.0
Delay disc. indifference point, 4s delay1.51.64.5-0.9-2.1-0.11.11.0-1.31.80.0
Delay disc. indifference point, 8s delay0.20.20.40.3-0.3-0.50.70.6-0.30.30.0
Indifference point function ln k0.60.81.2-0.90.21.1-1.1-1.10.91.10.0
Indifference point function log k0.60.81.2-0.90.21.1-1.1-1.10.91.10.0
Patch foraging total patch changes 0 sec1.62.65.12.10.5-2.21.81.7-1.6-1.50.0
Patch foraging total patch changes 12 sec1.62.14.21.80.3-2.11.81.6-1.5-1.00.0
Patch foraging total patch changes 18 sec2.93.77.92.81.6-2.61.71.4-1.3-2.50.0
Patch foraging total patch changes 24 sec2.53.08.83.02.2-2.30.91.0-0.4-1.80.0
Patch foraging total patch changes 6 sec2.13.26.42.50.8-2.51.91.8-1.7-1.50.0
Patch foraging time to switch 0 sec0.50.72.51.61.3-1.10.20.3-0.1-0.50.0
Patch foraging water rate 0 sec0.20.40.80.0-0.5-0.60.90.9-0.9-0.20.0
Patch foraging water rate 12 sec0.30.50.91.00.9-0.90.40.4-0.1-0.90.0
Patch foraging water rate 18 sec0.20.20.9-0.2-0.6-0.00.40.3-0.3-0.90.0
Patch foraging water rate 24 sec0.91.22.60.1-1.1-1.01.61.6-1.6-0.00.0
Patch foraging water rate 6 sec0.20.40.80.70.6-0.90.60.6-0.5-0.40.0
Seeking ratio, delayed vs. immediate footshock0.20.30.7-0.2-0.9-0.20.60.6-0.70.40.0
Distance traveled before self-admin0.30.40.9-1.0-0.41.0-0.6-0.60.30.10.0
Distance traveled after self-admin0.30.31.0-1.0-0.90.7-0.1-0.0-0.10.60.0
Extensor digitorum longus weight0.20.61.9-1.4-1.01.2-0.5-0.40.30.70.0
Bone: elastic displacement0.40.51.11.00.2-1.10.80.8-0.8-0.00.0
Bone: elastic work1.21.63.30.5-1.2-1.21.71.7-1.80.60.0
Bone: endosteal estimation2.76.016.0-4.0-3.92.7-0.3-0.2-0.23.00.0
Bone: endosteal perimeter2.75.614.1-3.8-2.23.3-1.8-1.71.42.50.0
Epididymis fat weight6.916.134.55.51.7-5.94.54.3-3.9-2.70.0
Delta time in closed arm before/after self-admin0.30.31.5-0.1-0.6-0.10.30.3-0.41.20.0
Delta time in open arm before/after self-admin0.20.21.40.30.1-0.30.20.2-0.4-1.20.0
Diff in mean of infusions in LGA sessions1.51.65.40.82.30.2-1.4-1.41.6-0.50.0
Delay discount exponential model param1.21.32.3-0.41.01.1-1.5-1.41.3-1.50.0
Extinction: sum of active levers before priming0.30.31.20.61.1-0.1-0.4-0.40.60.20.0
Active lever presses in extinction session 60.50.41.60.91.3-0.80.30.3-0.0-0.50.0
Bone: final force3.86.113.10.9-2.2-2.43.53.5-3.6-0.00.0
Bone: final moment3.35.411.60.7-2.2-2.23.33.3-3.4-0.10.0
Food consumed during 24 hour testing period0.50.62.4-1.3-1.60.80.10.0-0.30.00.0
Glucose4.97.414.5-3.7-1.63.8-2.8-2.82.52.70.0
Heart weight0.20.31.5-0.5-0.50.10.20.1-0.21.20.0
Delay discount hyperbolic model param1.31.32.9-0.11.20.9-1.4-1.41.2-1.70.0
Intermittent access intake day 1-15 change0.40.30.7-0.0-0.7-0.50.90.7-0.8-0.50.0
Intermittent access intake escalation0.20.20.8-0.8-0.90.40.20.0-0.3-0.30.0
Intermittent access intake escalation 21.51.54.7-2.2-1.11.9-1.0-1.10.60.20.0
Intermitt. access day 1 inactive lever presses0.70.73.2-1.2-0.60.8-0.2-0.10.11.80.0
Intermitt. access day 15 inactive lever presses1.11.22.8-0.1-0.9-0.81.61.7-1.60.00.0
Intermitt. access escalation Index1.61.43.40.01.40.8-1.6-1.51.80.40.0
Intermittent access day 1 total infusions0.20.20.50.70.7-0.1-0.4-0.30.6-0.00.0
Intermittent access day 15 total infusions0.00.00.20.40.1-0.20.00.00.1-0.30.0
Intermittent access terminal intake (last 3 days)0.10.10.10.30.0-0.40.40.4-0.30.10.0
Intermittent access total infusions0.10.10.30.50.3-0.40.20.20.0-0.20.0
Intermittent access day 1 locomotion0.30.30.8-0.3-0.50.7-0.7-0.60.90.10.0
Intermittent access day 15 total locomotion0.50.52.2-1.1-1.50.60.20.2-0.40.30.0
Intermittent access total locomotion0.40.41.9-0.9-1.40.60.10.1-0.2-0.30.0
Intermittent access standard deviation1.61.73.80.6-0.8-1.41.91.8-2.0-0.30.0
Left kidney weight1.85.010.7-0.5-3.3-1.23.02.9-3.20.20.0
Right kidney weight1.44.013.6-1.5-3.7-0.22.22.0-2.60.10.0
Cocaine induced anxiety2.32.65.1-1.30.72.1-2.3-2.22.1-0.50.0
Post-drug Anxiety0.91.12.0-1.00.61.3-1.4-1.31.30.10.0
Baseline Anxiety0.50.61.21.00.7-1.10.70.7-0.60.80.0
Tail length2.47.428.4-3.8-5.31.71.41.4-1.92.40.0
Length with tail2.07.227.9-3.1-5.30.92.12.1-2.61.90.0
Length without tail1.43.010.0-1.4-3.2-0.11.81.8-2.11.10.0
Times rat made contact with spout1.21.44.31.92.1-1.2-0.0-0.10.3-1.40.0
Lifetime Intake0.00.10.20.40.2-0.30.10.2-0.00.20.0
Liver weight, left0.71.03.9-1.6-2.01.3-0.2-0.20.10.40.0
Liver weight, right2.64.314.2-3.1-3.81.80.40.6-0.82.50.0
Locomotor activity1.52.37.2-2.6-2.71.9-0.3-0.2-0.00.80.0
Locomotor testing distance0.30.51.3-1.2-1.20.9-0.3-0.10.10.30.0
Locomotor testing rearing0.50.72.4-1.4-1.61.0-0.10.2-0.00.50.0
Locomotion in novel chamber0.30.41.4-0.2-1.2-0.30.80.7-0.70.40.0
Locomotion in novel chamber post-restriction0.40.51.00.4-0.6-0.81.00.9-0.90.30.0
Fecal boli incidents, locomotor time 10.30.40.90.11.00.4-0.8-0.60.8-0.40.0
Change in fecal boli incidents, locomotor task0.60.62.7-0.6-1.0-0.00.50.5-0.41.60.0
Time >=10cm from walls, locomotor time 10.60.62.1-1.5-0.91.0-0.20.0-0.20.70.0
Bouts of movement, locomotor time 11.11.22.7-0.80.51.3-1.5-1.71.4-0.50.0
Total resting periods, locomotor time 10.91.02.0-1.00.01.3-1.2-1.41.2-0.50.0
Rest time, locomotor task time 10.90.92.5-1.6-1.01.5-0.8-0.80.8-0.00.0
Distance moved, locomotor task time 10.70.71.30.8-0.0-1.11.21.1-1.2-0.00.0
Vertical activity count, locomotor time 10.60.61.60.80.1-1.00.90.9-1.3-0.40.0
Time >=10cm from walls, locomotor time 20.40.41.0-1.0-0.80.8-0.4-0.2-0.20.90.0
Bouts of movement, locomotor time 21.41.54.7-1.8-2.21.3-0.3-0.10.21.40.0
Total resting periods, locomotor time 21.92.04.8-2.2-2.11.8-0.7-0.50.61.60.0
Rest time, locomotor task time 22.73.17.6-2.7-1.42.7-1.8-1.71.30.70.0
Distance moved, locomotor task time 21.61.83.71.80.4-1.91.61.5-1.6-0.70.0
Vertical activity count, locomotor time 20.50.61.31.10.5-1.10.70.6-0.9-0.40.0
Light reinforcement 10.30.51.41.00.4-1.20.90.7-0.60.40.0
Light reinforcement 20.30.41.7-0.8-1.30.20.50.3-0.40.50.0
Bone: marrow area2.75.815.6-4.0-3.82.6-0.3-0.2-0.23.10.0
Bone: maximum diameter1.22.16.2-2.5-2.21.9-0.6-0.50.21.30.0
Bone: maximum force2.94.910.60.5-2.3-1.93.13.1-3.3-0.20.0
Bone: maximum moment2.54.39.20.3-2.4-1.72.92.9-3.0-0.20.0
Mean time between licks in bursts2.43.37.3-2.7-1.32.6-1.7-1.71.51.70.0
Mean num. licks in bursts1.21.54.02.01.1-1.81.00.9-0.7-1.00.0
Cd content in liver1.01.11.91.10.0-1.31.21.1-1.1-1.40.0
Co content in liver1.72.03.61.5-0.1-1.91.81.9-1.7-0.30.0
Cu content in liver1.72.08.72.12.9-1.0-0.7-0.71.0-0.60.0
Fe content in liver0.70.81.61.00.0-1.31.21.2-1.1-0.20.0
K content in liver0.10.10.20.00.40.2-0.4-0.40.30.20.0
Mg content in liver2.72.85.0-1.50.42.1-2.2-2.22.11.10.0
Mn content in liver4.95.610.6-3.1-0.93.2-2.6-2.52.22.50.0
Na content in liver0.30.31.20.50.1-0.60.50.5-0.5-1.10.0
Rb content in liver0.40.61.30.21.10.4-1.0-1.01.00.10.0
Se content in liver3.34.07.9-2.6-0.82.8-2.2-2.12.01.90.0
Sr content in liver0.80.72.4-1.1-1.30.60.10.2-0.31.60.0
Zn content in liver0.40.53.2-0.4-0.10.4-0.3-0.10.21.80.0
Bone: minimum diameter1.52.88.0-2.8-2.42.1-0.6-0.60.31.70.0
Time in familiar zone, hab. session 12.32.16.72.12.6-1.0-0.5-0.50.7-2.00.0
Time in novel zone, hab. session 11.71.74.2-1.9-2.01.10.10.1-0.32.00.0
Total zone transitions, hab. session 10.30.41.00.41.00.1-0.7-0.70.8-0.80.0
Total locomotion distance, hab. session 10.20.31.00.51.0-0.1-0.5-0.50.6-0.70.0
Locomotion velocity, hab. session 10.20.20.70.70.9-0.4-0.1-0.10.2-0.70.0
Time in familiar zone, hab. session 20.20.20.80.80.9-0.5-0.0-0.00.1-0.40.0
Time in novel zone, hab. session 20.10.10.5-0.3-0.70.00.40.4-0.4-0.10.0
Total zone transitions, hab. session 20.20.30.90.70.4-0.60.30.4-0.3-0.90.0
Total locomotion distance, hab. session 20.50.71.90.71.4-0.1-0.7-0.70.8-1.10.0
Locomotion velocity, hab. session 20.50.71.90.61.40.0-0.8-0.80.9-1.00.0
Novel to familiar place preference ratio0.20.20.30.60.3-0.60.40.4-0.3-0.50.0
Novelty place preference0.10.10.20.3-0.0-0.50.40.5-0.5-0.30.0
Time in novel zone, NPP test0.10.10.30.2-0.2-0.40.50.5-0.5-0.20.0
Total zone transitions, NPP test0.70.92.10.31.20.4-1.0-1.11.2-1.40.0
Total locomotion distance, NPP test0.70.92.40.91.5-0.2-0.7-0.70.8-1.50.0
Locomotion velocity, NPP test1.01.44.01.12.0-0.2-1.0-1.01.1-1.60.0
Intraocular pressure0.60.82.30.41.10.3-0.9-1.01.0-1.50.0
Delta distance traveled before/after self-admin0.50.61.2-0.0-1.0-0.51.01.1-1.00.10.0
Delta ambulatory time before/after self-admin0.30.31.2-0.6-1.10.20.40.5-0.40.60.0
Parametrial fat weight1.42.76.00.4-1.6-1.42.22.3-2.5-0.50.0
Pavlov. Cond. lever latency2.53.26.72.30.6-2.62.12.1-1.9-1.10.0
Pavlov. Cond. magazine entry latency2.43.26.6-2.2-0.52.6-2.1-2.12.00.50.0
Pavlov. Cond. change in total contacts1.01.13.1-1.8-1.61.4-0.4-0.40.20.70.0
Pavlov. Cond. index score3.24.08.6-2.6-0.72.9-2.4-2.42.20.80.0
Pavlov. Cond. latency score2.83.57.8-2.6-0.92.8-2.1-2.11.90.90.0
Pavlov. Cond. lever contacts2.22.55.6-2.3-1.02.4-1.6-1.61.41.00.0
Pavlov. Cond. magazine entry number2.22.85.01.7-0.2-2.22.22.2-2.1-0.60.0
Pavlov. Cond. intertrial magazine entries1.11.43.71.91.6-1.50.50.4-0.3-1.40.0
Pavlov. Cond. lever-magazine prob. diff.3.24.08.3-2.5-0.52.9-2.4-2.42.20.80.0
Pavlov. Cond. response bias3.13.77.6-2.3-0.32.8-2.4-2.42.30.70.0
Pavlov. Cond. lever latency0.10.20.6-0.4-0.80.10.30.2-0.40.40.0
Pavlov. Cond. magazine entry latency0.30.40.9-0.6-1.00.20.40.5-0.50.90.0
Pavlov. Cond. change in total contacts0.30.40.70.70.0-0.80.80.8-0.7-0.30.0
Pavlov. Cond. index score0.00.00.00.10.0-0.10.10.1-0.10.10.0
Pavlov. Cond. latency score0.10.10.20.1-0.1-0.30.30.4-0.30.30.0
Pavlov. Cond. lever contacts0.30.51.11.10.9-0.80.30.3-0.1-1.00.0
Pavlov. Cond. magazine entry number0.20.20.4-0.00.50.3-0.6-0.60.6-0.10.0
Pavlov. Cond. intertrial magazine entries1.82.44.2-1.60.22.1-2.0-2.02.00.60.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.10.0-0.10.10.2-0.10.20.0
Pavlov. Cond. response bias0.10.10.50.40.5-0.2-0.00.00.1-0.70.0
Time in closed arm before self-admin0.00.00.10.10.4-0.1-0.00.20.00.10.0
Time in closed arm after self-admin0.70.81.50.7-0.2-1.11.21.2-1.20.10.0
Time in open arm before self-admin0.60.71.3-0.9-0.21.1-0.9-1.11.0-0.50.0
Time in open arm after self-admin0.80.81.5-0.60.41.1-1.2-1.21.2-0.80.0
Bone: periosteal estimation1.63.211.7-2.5-3.41.10.90.9-1.31.90.0
Bone: periosteal perimeter1.11.85.7-2.2-2.41.40.10.1-0.41.30.0
Bone: post-yield work1.01.43.4-1.8-1.01.8-1.1-1.11.00.40.0
Progressive ratio test 1 active lever presses0.10.10.20.40.2-0.0-0.3-0.10.40.40.0
Progressive ratio test 1 breakpoint0.10.10.20.50.3-0.1-0.2-0.10.30.40.0
Progressive ratio test 1 inactive lever presses0.50.51.51.20.9-1.00.50.5-0.4-0.30.0
Progressive ratio test 2 active lever presses0.30.31.10.71.0-0.2-0.4-0.50.5-0.30.0
Progressive ratio test 2 breakpoint0.50.62.10.81.4-0.2-0.6-0.60.7-0.70.0
Progressive ratio test 2 inactive lever presses0.10.10.3-0.2-0.50.00.40.5-0.5-0.10.0
Incentive Sensitization - Responses0.30.31.00.31.00.0-0.5-0.60.6-0.50.0
Incentive Sensitization - Breakpoint0.40.41.20.31.10.1-0.6-0.70.7-0.70.0
Sum of active levers in priming session hrs 5-60.30.30.70.10.80.1-0.5-0.50.80.70.0
Progressive ratio2.73.16.20.3-2.2-1.42.42.5-2.30.70.0
Food seeking constrained by brief footshock0.10.10.50.10.10.0-0.1-0.10.2-0.70.0
Seeking ratio, punishment vs. effort2.32.85.5-0.22.11.3-2.3-2.32.2-0.60.0
Retroperitoneal fat weight0.20.71.60.3-1.0-0.81.21.1-1.3-0.10.0
Reaction time number correct0.91.32.71.61.0-1.61.11.0-1.0-0.90.0
Reaction time mean minus median3.14.19.7-3.1-1.93.1-1.9-1.91.70.20.0
Reaction time mean minus median AUC2.33.06.9-2.6-1.32.6-1.8-1.71.60.20.0
Reaction time num false alarms0.20.30.9-0.6-0.90.10.50.4-0.40.50.0
Reaction time num false alarms AUC0.30.41.4-0.7-1.20.00.60.6-0.60.70.0
Reaction time trials correct on left0.91.32.71.61.0-1.61.11.0-1.0-0.90.0
Reaction time trials on left0.81.12.41.40.9-1.61.11.0-1.0-0.90.0
Reaction time mean3.04.29.2-2.9-1.43.0-2.2-2.12.00.80.0
Reaction time mean AUC3.14.29.3-2.9-1.43.0-2.2-2.12.00.70.0
Median of all reaction times2.02.75.6-2.2-1.02.4-1.8-1.81.71.00.0
Reaction time omissions2.12.96.6-2.5-1.22.6-1.8-1.71.60.10.0
Reaction time false alarm rate0.60.92.3-1.5-1.51.0-0.1-0.10.01.20.0
Reaction time premature initiation rate0.71.02.30.1-1.1-0.91.41.5-1.30.40.0
Reaction time premature initiations1.42.04.40.9-0.6-1.72.02.1-1.9-0.00.0
Std. dev. reaction times3.24.510.7-3.3-2.13.2-1.9-1.81.70.80.0
Reaction time trials completed0.81.12.41.40.9-1.61.11.0-1.0-0.90.0
Reaction time trials AUC0.81.12.41.50.9-1.51.00.9-0.9-0.90.0
Run reversals in cocaine runway, females1.11.12.61.40.9-1.30.90.6-0.8-1.60.0
Run reversals in cocaine runway, males1.61.64.3-2.1-2.01.7-0.5-0.30.40.90.0
Latency to leave start box in cocaine runway0.10.10.2-0.1-0.1-0.10.20.5-0.10.40.0
Latency to leave start box in cocaine runway, F0.20.20.5-0.20.40.4-0.6-0.40.7-0.20.0
Latency to leave start box in cocaine runway, M1.11.12.40.5-0.6-1.21.51.5-1.50.10.0
Std. dev. time between licks in bursts2.42.96.9-2.6-1.62.4-1.3-1.31.01.90.0
Total sessions with >9 infusions0.10.10.40.2-0.3-0.10.10.2-0.20.60.0
Short access day 1 total inactive lever presses1.11.23.2-1.8-1.31.5-0.8-0.60.51.20.0
Short access day 10 total inactive lever presses0.20.30.9-0.9-0.30.8-0.4-0.40.40.30.0
Short access day 1 total infusions0.30.30.9-0.00.30.4-0.6-0.50.61.00.0
Short access day 10 total infusions0.10.10.20.3-0.0-0.30.30.4-0.40.30.0
Short access total infusions0.10.10.40.2-0.0-0.20.20.4-0.30.60.0
Short access day 1 locomotion1.61.83.6-0.01.61.0-1.9-1.81.90.30.0
Short access day 10 total locomotion0.91.02.8-1.7-0.91.4-0.7-0.70.31.10.0
Short access total locomotion0.30.30.6-0.60.00.7-0.7-0.60.60.80.0
One hour access (0.3 mA shock)0.30.30.70.10.80.4-0.8-0.70.80.10.0
Compulsive drug intake1.81.83.6-0.31.51.2-1.9-1.71.81.00.0
One hour access (shock baseline)0.20.30.6-0.3-0.80.00.50.6-0.6-0.80.0
Social response proportion0.60.73.0-1.0-0.80.8-0.4-0.20.21.70.0
Social responses0.20.21.0-0.4-0.60.10.20.3-0.41.00.0
Social time2.43.27.4-2.7-1.92.5-1.3-1.21.31.90.0
Soleus weight2.06.015.8-4.0-2.83.3-1.5-1.41.02.80.0
Bone: stiffness1.01.63.10.8-0.7-1.41.71.7-1.7-0.80.0
Tibialis anterior weight0.41.32.81.71.0-1.61.01.0-0.9-1.10.0
Time to tail flick, vehicle, before self-admin0.30.30.5-0.6-0.50.7-0.6-0.60.5-0.00.0
Time to tail flick, vehicle, after self-admin1.41.42.8-1.40.11.7-1.5-1.41.21.00.0
Time to tail flick, test, before self-admin0.20.20.40.60.5-0.60.50.4-0.1-0.30.0
Time to tail flick, test, after self-admin1.31.32.4-0.9-0.11.4-1.4-1.61.5-0.90.0
Delta time to tail flick, vehicle, before/after SA0.40.40.8-0.20.90.5-0.8-0.70.90.20.0
Delta time to tail flick, test, before/after SA0.60.51.1-0.10.30.6-0.9-1.00.9-1.00.0
Tibia length1.64.515.3-2.9-3.91.40.90.9-1.42.60.0
Ambulatory time before self-admin0.10.10.1-0.3-0.20.3-0.1-0.30.1-0.40.0
Ambulatory time after self-admin0.20.20.9-0.9-0.70.7-0.2-0.10.00.30.0
Bone: tissue strength2.52.45.00.4-1.5-1.42.22.2-2.2-0.30.0
Total heroin consumption0.10.10.3-0.10.20.1-0.1-0.30.2-0.60.0
Bone: trabecular number0.81.34.71.62.2-0.7-0.6-0.60.8-1.20.0
Bone: trabecular spacing1.72.27.0-1.2-2.6-0.01.51.5-1.71.20.0
Bone: trabecular thickness0.50.62.51.01.6-0.3-0.6-0.60.7-0.30.0
Bone: trabecular tissue density0.91.32.80.0-1.3-0.91.61.6-1.70.40.0
Water consumed over 24 hours0.10.20.6-0.5-0.20.5-0.3-0.30.20.80.0
Number of responses in last shaping day0.50.52.9-0.5-0.80.20.10.3-0.21.70.0