Hub : Genes

Gm2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Gm2a 0.52 0.23 7.4e-10 0.06 0.08 0.07 0.06 2.8e-07 8.8e-09 2.5e-08 3.4e-07
2 Brain mRNA stability Gm2a 0.1 0.1 5.5e-05 0.04 0.04 0.04 0.04 6.9e-05 2.7e-04 1.3e-04 7.2e-05
3 Adipose gene expression Gm2a 0.64 0.14 0.0e+00 0.3 0.33 0.33 0.3 1.3e-33 5.9e-38 9.4e-38 3.4e-34
4 pVTA gene expression Gm2a 0.17 0.11 6.7e-16 0.16 0.19 0.18 0.18 3.2e-13 3.3e-15 1.7e-14 1.8e-14
5 PL mRNA stability Gm2a 0.06 0.05 1.9e-08 0.06 0.06 0.06 0.06 6.4e-07 6.9e-07 1.6e-07 3.3e-07
6 Liver gene expression Gm2a 0.07 0.06 8.6e-07 0.03 0.04 0.03 0.03 1.5e-04 5.3e-05 2.5e-04 1.4e-04
7 Brain gene expression Gm2a 0.18 0.1 0.0e+00 0.22 0.22 0.22 0.23 1.1e-20 3.7e-20 3.2e-20 6.3e-21
8 PL gene expression Gm2a 0.12 0.1 1.8e-11 0.1 0.1 0.09 0.1 1.5e-10 6.4e-11 3.4e-10 4.6e-11
9 IL mRNA stability Gm2a 0.12 0.11 8.2e-03 0.03 0.01 0.02 0.01 5.3e-02 1.6e-01 1.3e-01 1.8e-01
10 IC gene expression Gm2a 0.38 0.17 6.1e-11 0.23 0.22 0.23 0.22 5.7e-10 8.4e-10 6.3e-10 1.5e-09
11 BLA gene expression Gm2a 0.23 0.13 7.1e-14 0.26 0.24 0.26 0.25 3.4e-14 9.9e-13 7.8e-14 2.7e-13
12 NAcc gene expression Gm2a 0.11 0.07 0.0e+00 0.12 0.12 0.12 0.12 4.0e-18 1.6e-17 3.5e-17 1.4e-17
13 Liver mRNA stability Gm2a 0.28 0.19 6.9e-04 0.01 0.03 0.01 0.01 1.9e-02 2.1e-04 6.0e-02 1.2e-02
14 IC mRNA stability Gm2a 0.33 0.18 1.6e-05 0.1 0.1 0.09 0.09 8.7e-05 8.2e-05 9.5e-05 1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.52.3-1.50.9-1.00.40.50.30.20.20.20.10.10.0-1.4-0.2
Area under the delay curve0.10.10.20.4-0.30.4-0.4-0.3-0.4-0.3-0.4-0.3-0.4-0.4-0.40.3-0.3
BMI with tail0.10.53.0-1.71.0-0.50.10.4-0.2-0.3-0.3-0.6-0.3-0.6-0.3-0.4-1.1
BMI without tail0.30.91.50.1-0.60.8-0.9-0.7-1.0-1.1-1.1-1.2-0.9-1.0-1.00.8-1.2
Body weight0.83.34.51.1-1.21.8-1.8-1.5-1.9-1.9-2.0-2.1-1.8-2.0-1.82.0-2.1
Weight adjusted by age0.10.10.50.7-0.70.2-0.2-0.5-0.2-0.2-0.2-0.2-0.1-0.20.00.20.0
Bone surface0.00.00.1-0.3-0.0-0.0-0.1-0.2-0.1-0.2-0.2-0.2-0.1-0.2-0.3-0.2-0.3
Bone volume0.50.92.9-1.71.2-1.20.80.90.70.60.60.60.60.50.5-1.50.2
Breakpoint value in progressive ratio session1.01.21.6-1.01.1-0.91.11.21.11.31.31.11.21.21.0-0.71.2
Number of licking bursts0.20.41.60.9-1.30.7-0.5-0.7-0.4-0.3-0.3-0.4-0.4-0.3-0.40.8-0.1
Context. condit. distance diff. score0.10.10.5-0.50.2-0.3-0.10.0-0.2-0.3-0.2-0.1-0.4-0.3-0.4-0.7-0.4
Locomotion velocity, session 10.10.10.20.50.10.10.10.10.10.20.20.20.30.20.30.10.4
Locomotion distance, session 10.20.30.50.2-0.10.5-0.6-0.3-0.6-0.6-0.6-0.6-0.6-0.7-0.60.6-0.7
Locomotion velocity, session 20.81.01.31.1-1.11.0-1.1-1.1-1.0-1.0-1.0-1.0-0.9-1.0-0.90.8-0.8
Locomotion distance, session 20.50.71.81.2-0.81.1-0.9-0.7-0.8-0.7-0.8-0.8-0.6-0.7-0.61.3-0.6
Locomotion velocity, session 32.73.13.81.3-1.71.6-1.8-1.7-1.9-1.9-1.9-2.0-1.8-1.9-1.81.3-1.9
Locomotion distance, session 32.02.23.10.9-1.11.2-1.6-1.3-1.6-1.7-1.6-1.7-1.7-1.8-1.70.7-1.7
Stereotopy head waving bouts, day 30.20.30.50.10.3-0.00.40.50.50.60.60.60.60.50.50.50.7
Stereotopy head waving duration, day 31.82.12.6-0.91.4-1.11.51.61.61.61.61.61.61.61.6-0.51.6
Locomotion velocity, session 70.10.10.7-0.80.2-0.40.1-0.0-0.0-0.1-0.1-0.1-0.2-0.2-0.2-0.5-0.4
Locomotion distance, session 70.10.10.3-0.50.5-0.30.40.50.40.30.30.30.30.40.3-0.10.2
Stereotopy head waving bouts, day 70.20.20.3-0.30.3-0.40.40.50.50.50.50.50.40.40.4-0.30.5
Stereotopy head waving duration, day 71.01.22.1-0.40.8-0.81.11.11.21.31.31.31.31.21.2-0.61.5
Locomotion velocity, session 82.32.83.71.3-1.91.4-1.7-1.9-1.8-1.7-1.7-1.7-1.7-1.8-1.70.8-1.8
Locomotion distance, session 80.81.21.50.8-0.91.0-1.1-1.0-1.2-1.2-1.2-1.2-1.2-1.2-1.20.9-1.2
Degree of sensitization distance2.72.83.9-1.21.4-1.31.81.61.91.91.81.81.82.01.9-0.61.8
Degree of sensitization stereotypy0.10.10.1-0.20.2-0.30.30.30.30.30.30.20.30.30.2-0.20.3
Conditioned locomotion0.70.82.01.4-1.31.1-0.8-0.9-0.7-0.7-0.8-0.7-0.7-0.7-0.71.3-0.4
Cocaine response after cond. corrected0.30.31.6-1.20.6-0.80.40.30.30.10.20.30.10.10.0-1.0-0.2
Cocaine response after cond. not corrected1.41.64.5-2.11.6-1.71.31.21.10.90.91.01.00.90.9-1.70.4
Cocaine response before conditioning2.63.14.7-1.92.2-1.81.81.91.81.71.61.51.91.61.8-1.51.4
Saline control response1.21.62.6-1.51.4-1.31.41.21.31.31.00.91.61.21.5-0.90.8
Bone: connectivity density0.10.10.4-0.60.3-0.40.20.20.10.10.20.10.10.10.1-0.6-0.0
Bone: cortical apparent density0.70.91.6-1.21.2-1.21.01.00.90.80.90.90.70.90.7-1.30.8
Bone: cortical area0.71.11.41.1-1.11.1-1.1-1.2-1.0-1.0-1.0-0.9-1.1-0.9-1.10.9-0.9
Bone: cortical porosity0.20.20.40.2-0.50.3-0.5-0.6-0.6-0.5-0.5-0.6-0.5-0.6-0.5-0.1-0.6
Bone: cortical porosity0.60.61.6-0.90.8-1.00.80.60.70.70.80.80.70.60.8-1.30.6
Bone: cortical thickness0.40.70.90.7-0.90.9-0.9-0.9-0.9-0.9-0.8-0.8-0.9-0.8-1.00.7-0.8
Bone: cortical thickness0.10.10.20.10.3-0.00.20.30.30.30.30.30.20.40.20.20.4
Bone: cortical tissue density0.91.21.9-1.31.4-1.31.11.11.01.01.01.00.81.00.8-1.40.9
Condit. Reinf. active minus inactive responses0.20.20.5-0.0-0.10.3-0.5-0.2-0.5-0.6-0.6-0.6-0.6-0.6-0.60.3-0.7
Condit. Reinf. active-inactive response ratio0.91.01.30.6-0.80.9-1.0-0.7-1.0-1.1-1.1-1.1-1.1-1.1-1.10.9-1.1
Condit. Reinf. active responses0.00.10.2-0.10.5-0.10.20.40.20.20.10.10.20.20.20.10.2
Condit. Reinf. inactive responses1.62.02.6-0.91.4-1.21.51.41.51.51.51.41.61.61.5-1.01.5
Incentive salience index mean1.31.52.11.1-1.01.3-1.3-1.0-1.3-1.3-1.3-1.3-1.3-1.2-1.31.4-1.2
Condit. Reinf. lever presses3.04.36.72.5-2.12.4-2.1-1.9-2.0-1.9-2.0-1.9-1.8-1.8-1.92.6-1.6
Condit. Reinf. active minus inactive responses1.01.34.1-2.01.3-1.51.21.11.00.70.70.80.90.80.8-1.50.3
Condit. Reinf. active-inactive response ratio0.10.10.2-0.50.1-0.1-0.1-0.1-0.2-0.3-0.4-0.2-0.2-0.3-0.2-0.1-0.5
Condit. Reinf. active responses1.92.64.5-2.11.7-1.91.71.51.61.51.51.51.61.51.5-1.81.2
Condit. Reinf. inactive responses3.84.95.6-2.12.0-2.32.32.12.32.32.32.22.42.32.3-2.12.1
Condit. Reinf. lever presses0.40.51.8-1.30.7-1.00.80.40.60.50.50.50.60.40.6-1.00.1
Condit. Reinf. lever reinforcers received1.92.75.7-2.41.7-2.01.71.51.61.41.41.51.51.41.4-2.00.9
Conditioned reinforcement - actives0.10.20.40.4-0.30.4-0.4-0.5-0.4-0.1-0.0-0.6-0.6-0.6-0.60.6-0.3
Conditioned reinforcement - inactives0.30.51.1-0.30.6-0.50.70.60.81.01.00.70.50.70.5-0.21.0
Conditioned locomotion0.10.10.3-0.30.2-0.30.40.30.40.60.60.20.30.20.4-0.10.4
Patch foraging indifference point 0 sec3.46.311.0-3.32.9-2.82.62.62.42.32.22.22.42.32.5-2.61.8
Patch foraging indifference point AUC0.00.00.1-0.30.3-0.10.10.20.0-0.1-0.10.00.10.10.1-0.1-0.1
Delay disc. indifference point, 0s delay0.00.00.10.3-0.40.1-0.1-0.2-0.0-0.0-0.0-0.0-0.10.1-0.10.10.1
Delay disc. indifference point, 16s delay0.00.00.2-0.40.2-0.20.20.10.10.10.00.1-0.00.00.1-0.2-0.1
Delay disc. indifference point, 2s delay1.11.31.80.7-0.91.0-1.1-1.1-1.2-1.2-1.3-1.3-1.2-1.3-1.10.8-1.3
Delay disc. indifference point, 24s delay0.10.10.20.2-0.40.2-0.2-0.3-0.2-0.2-0.3-0.2-0.4-0.4-0.30.2-0.2
Delay disc. indifference point, 4s delay1.11.11.9-0.30.7-0.81.01.11.11.21.11.21.11.21.2-0.81.4
Delay disc. indifference point, 8s delay0.40.50.70.9-0.60.8-0.8-0.5-0.7-0.7-0.7-0.7-0.7-0.8-0.70.8-0.5
Indifference point function ln k0.30.50.90.0-0.30.5-0.7-0.6-0.7-0.7-0.7-0.9-0.8-0.8-0.90.7-0.9
Indifference point function log k0.30.50.90.0-0.30.5-0.7-0.6-0.7-0.7-0.7-0.9-0.8-0.8-0.90.7-0.9
Patch foraging total patch changes 0 sec3.56.610.4-3.22.9-2.72.62.72.52.42.32.32.52.42.6-2.51.9
Patch foraging total patch changes 12 sec5.87.68.7-2.72.9-2.82.82.82.82.72.62.73.02.82.9-2.62.4
Patch foraging total patch changes 18 sec1.82.84.2-1.51.5-1.61.71.71.71.61.41.62.01.82.1-1.61.5
Patch foraging total patch changes 24 sec3.56.08.5-2.72.5-2.82.52.52.32.22.02.32.62.22.7-2.91.8
Patch foraging total patch changes 6 sec4.56.98.9-2.93.0-2.72.72.92.62.52.42.42.62.52.7-2.62.1
Patch foraging time to switch 0 sec0.40.81.70.20.2-0.50.80.50.91.21.11.11.01.00.9-0.61.3
Patch foraging water rate 0 sec0.40.91.7-0.0-0.60.7-0.9-0.8-1.0-1.1-1.1-1.2-1.0-1.0-0.90.7-1.3
Patch foraging water rate 12 sec0.20.50.70.9-0.60.8-0.8-0.5-0.7-0.8-0.8-0.7-0.6-0.6-0.60.8-0.5
Patch foraging water rate 18 sec0.91.32.1-1.01.3-1.01.21.51.21.11.21.11.21.21.2-0.71.2
Patch foraging water rate 24 sec0.60.82.6-1.61.3-1.00.91.20.80.70.70.50.70.60.7-0.70.3
Patch foraging water rate 6 sec1.72.53.92.0-1.91.8-1.6-1.6-1.5-1.4-1.4-1.5-1.4-1.4-1.31.8-1.1
Seeking ratio, delayed vs. immediate footshock0.81.01.6-1.31.1-1.21.10.91.00.80.80.90.90.80.8-1.20.7
Distance traveled before self-admin1.62.12.61.0-1.21.5-1.5-1.3-1.5-1.5-1.5-1.6-1.6-1.6-1.51.6-1.5
Distance traveled after self-admin0.00.00.10.3-0.30.3-0.2-0.1-0.2-0.1-0.1-0.0-0.1-0.1-0.10.40.0
Extensor digitorum longus weight0.31.01.3-1.11.0-1.01.10.91.11.11.10.91.11.11.0-0.70.9
Bone: elastic displacement0.10.21.0-0.8-0.3-0.50.1-0.20.0-0.10.0-0.1-0.1-0.1-0.1-1.0-0.3
Bone: elastic work0.70.92.10.4-1.50.6-0.8-1.3-0.9-1.0-0.9-0.9-1.1-1.0-1.10.1-1.0
Bone: endosteal estimation0.61.21.81.3-1.11.2-1.2-1.0-1.1-1.1-1.0-1.1-1.1-1.0-1.11.2-0.9
Bone: endosteal perimeter1.02.13.71.9-1.71.7-1.5-1.5-1.4-1.3-1.3-1.4-1.2-1.2-1.31.7-1.0
Epididymis fat weight0.10.51.00.2-0.30.4-0.7-0.7-0.8-0.8-0.7-0.8-0.8-1.0-0.7-0.1-0.8
Delta time in closed arm before/after self-admin0.30.31.0-1.01.0-0.70.40.70.40.10.20.20.20.20.2-0.60.0
Delta time in open arm before/after self-admin0.30.30.90.7-1.00.8-0.6-0.8-0.5-0.2-0.3-0.4-0.5-0.4-0.40.8-0.2
Diff in mean of infusions in LGA sessions0.20.31.9-1.40.9-0.50.20.70.10.0-0.1-0.1-0.0-0.1-0.1-0.6-0.5
Delay discount exponential model param0.10.10.1-0.40.3-0.30.30.20.30.30.30.30.40.40.3-0.30.2
Extinction: sum of active levers before priming0.00.00.3-0.10.10.3-0.20.0-0.1-0.10.0-0.1-0.2-0.1-0.30.60.1
Active lever presses in extinction session 61.71.74.1-2.01.6-1.41.31.41.21.21.31.11.11.11.0-1.20.8
Bone: final force1.42.32.81.4-1.61.5-1.6-1.6-1.6-1.5-1.5-1.5-1.6-1.5-1.71.2-1.4
Bone: final moment1.32.22.61.3-1.61.4-1.5-1.5-1.5-1.5-1.5-1.4-1.6-1.4-1.61.2-1.4
Food consumed during 24 hour testing period5.47.58.52.2-2.92.7-2.8-2.9-2.8-2.8-2.9-2.9-2.6-2.8-2.82.3-2.8
Glucose0.00.10.10.2-0.40.2-0.2-0.3-0.2-0.3-0.3-0.4-0.1-0.3-0.10.2-0.3
Heart weight1.92.94.01.4-1.51.7-1.8-1.6-1.8-1.7-1.7-1.8-1.9-2.0-1.81.4-1.7
Delay discount hyperbolic model param0.00.00.1-0.30.2-0.20.20.10.20.10.20.10.20.20.1-0.20.1
Intermittent access intake day 1-15 change0.40.93.01.2-0.30.10.50.20.81.11.11.11.11.11.00.11.7
Intermittent access intake escalation0.51.03.31.1-0.2-0.10.60.30.91.21.21.21.21.21.1-0.11.8
Intermittent access intake escalation 21.51.74.50.60.1-0.61.10.51.31.61.61.61.61.61.6-0.72.1
Intermitt. access day 1 inactive lever presses0.10.41.0-0.20.6-0.60.70.40.70.91.00.70.50.70.5-0.70.8
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1-0.10.10.20.10.20.10.10.10.10.10.10.1
Intermitt. access escalation Index0.20.30.9-1.00.2-0.0-0.20.2-0.4-0.4-0.4-0.7-0.6-0.7-0.60.2-0.9
Intermittent access day 1 total infusions0.10.20.70.4-0.10.6-0.5-0.2-0.4-0.2-0.3-0.5-0.7-0.5-0.60.8-0.3
Intermittent access day 15 total infusions0.10.21.01.0-0.30.5-0.1-0.10.10.50.50.20.10.20.10.70.8
Intermittent access terminal intake (last 3 days)0.20.31.10.9-0.20.30.10.00.30.70.70.40.30.40.30.51.0
Intermittent access total infusions0.20.21.11.0-0.30.8-0.4-0.2-0.30.10.1-0.2-0.4-0.2-0.31.00.3
Intermittent access day 1 locomotion0.10.10.40.5-0.20.4-0.3-0.0-0.20.10.0-0.3-0.4-0.3-0.30.60.1
Intermittent access day 15 total locomotion2.24.06.2-0.91.4-1.62.01.72.12.52.42.12.32.12.4-1.22.4
Intermittent access total locomotion2.32.85.1-0.61.3-1.21.61.71.82.12.11.81.81.81.8-0.82.3
Intermittent access standard deviation0.30.72.41.6-1.41.0-0.8-1.2-0.7-0.4-0.6-0.5-0.4-0.5-0.40.7-0.2
Left kidney weight5.324.528.24.3-5.04.9-5.0-5.1-5.0-5.1-5.3-5.1-5.0-5.1-4.84.6-4.9
Right kidney weight4.420.322.74.0-4.64.5-4.6-4.6-4.6-4.6-4.8-4.6-4.5-4.7-4.44.0-4.4
Cocaine induced anxiety0.00.00.2-0.30.2-0.10.10.20.10.30.4-0.10.1-0.10.1-0.10.1
Post-drug Anxiety0.20.20.4-0.10.1-0.30.40.40.50.40.50.40.50.40.5-0.10.6
Baseline Anxiety0.40.40.90.6-0.90.7-0.6-0.6-0.5-0.8-0.8-0.4-0.5-0.4-0.50.9-0.4
Tail length1.35.07.72.8-2.72.4-2.3-2.4-2.2-2.3-2.3-2.0-2.0-2.0-2.02.2-1.6
Length with tail1.35.58.02.8-2.52.6-2.4-2.4-2.3-2.3-2.4-2.2-2.1-2.2-2.12.6-1.8
Length without tail0.41.11.60.7-0.51.0-1.0-0.9-1.1-1.1-1.1-1.3-1.2-1.2-1.11.2-1.2
Times rat made contact with spout1.11.22.11.3-1.41.2-1.1-1.2-1.1-1.0-1.0-0.9-1.0-1.0-1.01.1-0.8
Lifetime Intake0.60.82.41.3-0.71.2-0.9-0.5-0.8-0.5-0.4-0.7-0.9-0.7-0.81.5-0.2
Liver weight, left0.10.10.3-0.00.5-0.30.40.30.40.30.20.40.60.50.5-0.30.4
Liver weight, right0.00.00.1-0.30.0-0.0-0.1-0.3-0.1-0.1-0.2-0.1-0.1-0.2-0.3-0.2-0.3
Locomotor activity1.32.02.4-1.51.5-1.51.51.31.51.41.51.51.21.31.2-1.41.3
Locomotor testing distance3.36.010.7-3.32.9-2.92.62.32.42.22.22.22.22.12.1-2.91.6
Locomotor testing rearing2.55.013.0-3.62.7-2.92.32.12.01.71.71.81.71.61.7-3.00.9
Locomotion in novel chamber0.10.10.30.3-0.1-0.00.10.20.20.30.30.30.40.30.2-0.00.6
Locomotion in novel chamber post-restriction0.10.20.7-0.80.8-0.50.40.50.30.10.10.30.30.30.4-0.50.1
Fecal boli incidents, locomotor time 10.20.21.2-1.10.5-0.70.50.50.40.10.00.20.30.20.3-0.7-0.0
Change in fecal boli incidents, locomotor task2.02.05.22.3-2.01.7-1.4-1.7-1.2-1.0-0.9-1.0-1.2-0.9-1.11.6-0.5
Time >=10cm from walls, locomotor time 13.33.54.0-1.81.6-1.92.01.72.01.91.92.01.91.91.9-1.71.9
Bouts of movement, locomotor time 10.40.50.9-0.90.8-0.80.70.80.70.60.60.60.50.60.6-0.70.5
Total resting periods, locomotor time 10.30.40.7-0.80.6-0.70.70.70.60.60.60.60.50.50.5-0.60.4
Rest time, locomotor task time 10.40.51.0-1.00.7-0.80.70.70.70.60.50.60.70.40.7-0.70.5
Distance moved, locomotor task time 10.10.10.30.5-0.60.4-0.4-0.4-0.4-0.2-0.1-0.3-0.3-0.3-0.40.3-0.3
Vertical activity count, locomotor time 10.20.40.7-0.60.8-0.60.60.80.60.80.80.70.60.70.5-0.50.5
Time >=10cm from walls, locomotor time 20.00.10.4-0.70.2-0.30.10.00.0-0.1-0.1-0.10.0-0.2-0.1-0.3-0.3
Bouts of movement, locomotor time 20.10.10.50.40.1-0.00.20.10.30.30.30.30.40.50.40.00.7
Total resting periods, locomotor time 20.10.10.40.30.1-0.10.30.10.40.30.40.30.40.50.4-0.00.7
Rest time, locomotor task time 21.82.22.7-1.51.5-1.51.61.41.61.61.51.41.51.51.6-1.41.4
Distance moved, locomotor task time 20.10.10.4-0.60.3-0.40.20.20.10.10.10.20.2-0.00.0-0.5-0.2
Vertical activity count, locomotor time 20.10.10.2-0.50.5-0.40.30.40.20.20.20.30.20.10.1-0.30.0
Light reinforcement 11.23.05.6-2.42.0-1.91.81.91.61.61.51.51.71.61.6-1.81.1
Light reinforcement 20.00.10.3-0.50.3-0.30.10.20.00.1-0.1-0.20.1-0.0-0.0-0.4-0.4
Bone: marrow area0.71.62.21.5-1.31.4-1.3-1.2-1.3-1.2-1.2-1.2-1.2-1.2-1.31.3-1.0
Bone: maximum diameter1.63.03.81.9-2.01.9-1.8-2.0-1.7-1.7-1.7-1.6-1.6-1.6-1.61.7-1.5
Bone: maximum force0.61.01.41.0-1.11.0-1.0-1.0-1.0-1.0-1.0-0.9-1.1-0.9-1.20.9-0.9
Bone: maximum moment0.50.91.30.9-1.01.0-1.0-0.9-1.0-1.0-0.9-0.8-1.1-0.8-1.10.9-0.9
Mean time between licks in bursts1.33.23.51.8-1.81.8-1.9-1.8-1.9-1.8-1.8-1.8-1.8-1.8-1.81.5-1.6
Mean num. licks in bursts0.10.10.6-0.50.8-0.40.30.40.20.20.20.20.20.10.3-0.50.0
Cd content in liver1.31.52.1-0.90.9-1.11.41.01.41.41.31.31.41.41.4-0.71.2
Co content in liver0.30.31.41.0-0.70.8-0.4-0.5-0.3-0.2-0.1-0.4-0.4-0.2-0.41.2-0.0
Cu content in liver0.10.10.40.5-0.70.4-0.2-0.7-0.2-0.1-0.1-0.1-0.1-0.2-0.10.4-0.0
Fe content in liver0.00.00.1-0.0-0.30.0-0.1-0.4-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.2-0.1
K content in liver11.511.012.83.4-3.43.6-3.4-3.3-3.3-3.3-3.4-3.4-3.1-3.2-3.13.6-3.0
Mg content in liver2.62.73.71.8-1.81.8-1.6-1.6-1.6-1.6-1.7-1.7-1.4-1.5-1.41.9-1.4
Mn content in liver0.20.20.70.7-0.20.40.10.20.30.30.20.10.40.40.50.90.6
Na content in liver1.51.62.51.6-1.51.4-1.3-1.4-1.2-1.2-1.2-1.2-1.1-1.2-1.11.3-0.9
Rb content in liver1.92.24.5-2.01.7-1.81.41.51.31.21.31.31.21.11.2-2.10.9
Se content in liver1.72.03.01.5-1.71.4-1.5-1.6-1.4-1.4-1.4-1.4-1.4-1.4-1.31.1-1.2
Sr content in liver0.10.10.50.40.00.30.00.10.10.1-0.0-0.10.20.10.20.70.1
Zn content in liver0.70.81.51.0-1.20.9-0.9-1.2-0.8-0.8-0.9-0.8-0.6-0.8-0.70.9-0.8
Bone: minimum diameter1.12.12.61.6-1.51.6-1.5-1.5-1.4-1.4-1.3-1.4-1.6-1.3-1.61.5-1.1
Time in familiar zone, hab. session 18.07.79.5-2.92.8-3.12.92.62.82.72.82.82.62.62.6-3.12.4
Time in novel zone, hab. session 14.54.55.41.4-1.92.0-2.2-2.2-2.2-2.3-2.3-2.3-2.2-2.2-2.21.8-2.3
Total zone transitions, hab. session 10.10.10.3-0.30.5-0.30.30.60.30.20.20.30.40.30.3-0.10.2
Total locomotion distance, hab. session 10.60.81.4-0.81.2-0.80.91.10.90.90.80.90.91.00.9-0.40.8
Locomotion velocity, hab. session 10.20.20.50.30.4-0.00.30.70.40.50.40.50.50.60.50.40.6
Time in familiar zone, hab. session 21.41.51.9-0.80.8-1.11.31.01.31.31.31.31.31.41.4-1.01.4
Time in novel zone, hab. session 23.23.24.11.2-1.51.6-1.9-1.8-1.9-1.9-1.9-1.9-2.0-2.0-2.01.3-2.0
Total zone transitions, hab. session 20.00.10.2-0.20.2-0.0-0.20.1-0.2-0.3-0.3-0.3-0.2-0.3-0.2-0.2-0.4
Total locomotion distance, hab. session 20.30.30.7-0.60.8-0.70.50.70.50.50.50.50.50.50.5-0.80.4
Locomotion velocity, hab. session 20.10.10.3-0.30.5-0.30.20.40.10.10.20.20.20.10.1-0.40.1
Novel to familiar place preference ratio0.30.31.0-0.81.0-0.50.60.80.60.50.50.50.50.50.4-0.30.3
Novelty place preference0.20.20.7-0.60.8-0.40.40.60.40.40.30.30.40.40.3-0.10.2
Time in novel zone, NPP test0.20.20.6-0.60.8-0.40.40.60.40.30.30.30.30.40.3-0.10.2
Total zone transitions, NPP test0.10.10.20.10.4-0.20.20.50.30.40.40.40.40.30.4-0.00.5
Total locomotion distance, NPP test0.10.20.6-0.10.8-0.30.40.70.40.40.40.40.50.40.5-0.10.5
Locomotion velocity, NPP test0.10.20.6-0.10.8-0.30.30.70.40.40.40.40.50.40.4-0.00.4
Intraocular pressure0.20.30.9-0.90.8-0.60.40.60.40.40.50.30.10.20.1-0.50.2
Delta distance traveled before/after self-admin1.51.62.0-0.91.1-1.31.31.31.31.21.21.41.31.41.3-1.31.3
Delta ambulatory time before/after self-admin2.02.53.1-1.11.3-1.51.61.51.71.61.51.71.71.81.7-1.51.6
Parametrial fat weight2.25.26.22.0-2.52.3-2.2-2.4-2.2-2.4-2.5-2.4-2.2-2.1-2.22.3-2.2
Pavlov. Cond. lever latency0.30.40.6-0.80.7-0.70.70.60.60.60.60.60.60.60.6-0.60.4
Pavlov. Cond. magazine entry latency0.20.20.50.7-0.50.6-0.5-0.5-0.4-0.3-0.4-0.4-0.4-0.4-0.50.5-0.2
Pavlov. Cond. change in total contacts0.10.10.50.7-0.20.3-0.2-0.0-0.10.00.00.1-0.1-0.1-0.10.10.3
Pavlov. Cond. index score0.30.40.91.0-0.80.7-0.6-0.7-0.6-0.4-0.5-0.4-0.5-0.5-0.50.5-0.2
Pavlov. Cond. latency score0.30.40.80.9-0.80.8-0.7-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.60.6-0.4
Pavlov. Cond. lever contacts0.30.40.80.9-0.80.8-0.7-0.7-0.6-0.5-0.5-0.5-0.5-0.6-0.60.6-0.3
Pavlov. Cond. magazine entry number0.00.00.1-0.10.1-0.00.20.20.20.10.10.00.20.20.30.30.1
Pavlov. Cond. intertrial magazine entries1.41.72.2-1.31.5-1.31.41.51.41.31.31.31.21.41.3-0.91.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.9-0.70.6-0.5-0.5-0.4-0.3-0.3-0.2-0.3-0.3-0.40.4-0.0
Pavlov. Cond. response bias0.10.10.40.6-0.40.4-0.4-0.3-0.3-0.2-0.2-0.1-0.2-0.2-0.30.20.0
Pavlov. Cond. lever latency0.70.92.60.60.4-0.30.71.00.91.11.11.11.01.21.0-0.11.6
Pavlov. Cond. magazine entry latency0.60.81.20.3-0.60.7-0.9-1.0-0.9-0.9-0.9-1.0-1.1-1.0-0.90.5-1.1
Pavlov. Cond. change in total contacts0.00.10.4-0.60.2-0.2-0.0-0.1-0.1-0.2-0.2-0.2-0.3-0.3-0.2-0.1-0.5
Pavlov. Cond. index score0.50.71.7-0.1-0.40.5-0.7-0.9-0.9-1.0-0.9-1.0-1.0-1.0-0.90.5-1.3
Pavlov. Cond. latency score0.70.91.9-0.0-0.50.6-0.9-0.9-1.0-1.0-1.0-1.1-1.1-1.1-1.00.6-1.4
Pavlov. Cond. lever contacts0.60.92.4-0.6-0.40.3-0.7-1.0-0.9-1.0-1.0-1.1-1.0-1.1-1.00.2-1.6
Pavlov. Cond. magazine entry number0.10.10.20.2-0.0-0.00.20.20.30.30.20.30.40.40.3-0.00.5
Pavlov. Cond. intertrial magazine entries2.43.74.5-1.51.7-1.82.01.92.02.02.02.12.02.12.0-1.62.0
Pavlov. Cond. lever-magazine prob. diff.0.50.71.5-0.1-0.40.5-0.7-0.8-0.9-0.9-0.9-1.0-1.0-1.0-0.90.6-1.2
Pavlov. Cond. response bias1.01.32.9-0.1-0.70.6-1.0-1.3-1.2-1.3-1.2-1.3-1.2-1.4-1.20.4-1.7
Time in closed arm before self-admin0.60.81.10.6-1.00.8-0.9-0.9-0.9-0.8-0.9-0.9-0.9-0.9-1.00.5-1.1
Time in closed arm after self-admin0.40.41.3-0.50.20.1-0.5-0.2-0.6-0.9-0.9-0.7-0.6-0.7-0.8-0.1-1.1
Time in open arm before self-admin0.30.31.00.30.3-0.30.50.50.60.60.80.60.60.60.6-0.21.0
Time in open arm after self-admin0.70.82.60.9-0.40.00.50.10.81.21.20.90.91.00.90.21.6
Bone: periosteal estimation1.02.12.61.6-1.51.6-1.5-1.5-1.5-1.4-1.4-1.4-1.5-1.4-1.51.4-1.2
Bone: periosteal perimeter0.91.51.91.4-1.21.4-1.3-1.2-1.2-1.1-1.1-1.2-1.2-1.1-1.21.3-1.0
Bone: post-yield work0.71.11.4-0.71.1-0.91.01.11.11.11.11.21.01.20.9-0.71.1
Progressive ratio test 1 active lever presses0.10.10.50.50.10.30.00.20.20.50.50.2-0.00.20.00.60.7
Progressive ratio test 1 breakpoint0.10.20.60.40.20.20.10.40.30.70.70.30.10.30.20.50.8
Progressive ratio test 1 inactive lever presses0.60.81.71.3-1.01.1-0.9-1.0-0.8-0.5-0.5-0.7-1.0-0.7-1.01.3-0.3
Progressive ratio test 2 active lever presses0.20.20.80.4-0.10.10.20.30.40.60.60.40.30.40.40.50.9
Progressive ratio test 2 breakpoint0.30.31.20.30.1-0.00.40.40.60.80.80.60.50.60.60.31.1
Progressive ratio test 2 inactive lever presses0.00.00.20.3-0.00.00.1-0.10.20.40.40.20.10.20.20.10.4
Incentive Sensitization - Responses0.60.81.2-0.70.6-0.81.00.81.01.01.11.00.91.01.0-0.51.1
Incentive Sensitization - Breakpoint0.50.71.0-0.60.5-0.70.90.70.90.90.91.00.81.00.9-0.51.0
Sum of active levers in priming session hrs 5-60.20.20.7-0.90.6-0.30.40.50.30.40.40.30.30.20.3-0.20.2
Progressive ratio0.40.61.5-0.20.9-0.50.71.20.70.60.60.80.80.80.9-0.30.9
Food seeking constrained by brief footshock0.10.10.2-0.40.2-0.40.40.50.30.30.30.30.30.30.3-0.40.3
Seeking ratio, punishment vs. effort0.40.61.30.1-0.90.5-0.7-1.1-0.8-0.7-0.8-0.8-0.9-0.8-0.90.2-1.0
Retroperitoneal fat weight0.93.85.71.0-1.41.7-2.0-1.9-2.1-2.1-2.2-2.2-2.0-2.3-2.01.3-2.4
Reaction time number correct0.61.22.9-1.71.1-1.41.11.01.01.00.91.00.91.00.9-1.40.6
Reaction time mean minus median0.10.41.11.1-0.70.8-0.6-0.6-0.5-0.3-0.3-0.4-0.5-0.4-0.40.9-0.1
Reaction time mean minus median AUC0.00.10.30.5-0.20.2-0.0-0.00.10.20.30.20.00.10.20.30.3
Reaction time num false alarms0.20.30.6-0.30.8-0.40.50.60.60.70.80.50.60.60.5-0.30.7
Reaction time num false alarms AUC0.40.71.3-0.20.8-0.50.70.70.81.11.10.70.90.90.8-0.31.1
Reaction time trials correct on left0.61.22.9-1.71.1-1.41.11.01.01.00.91.00.91.00.9-1.40.6
Reaction time trials on left0.61.22.8-1.71.0-1.41.10.91.00.90.81.00.90.90.9-1.40.6
Reaction time mean1.32.12.51.5-1.51.6-1.5-1.5-1.5-1.4-1.2-1.4-1.5-1.4-1.51.5-1.1
Reaction time mean AUC1.21.93.31.8-1.51.7-1.4-1.4-1.3-1.2-1.1-1.2-1.4-1.2-1.31.7-0.9
Median of all reaction times1.82.63.01.6-1.61.7-1.7-1.7-1.7-1.6-1.5-1.6-1.7-1.6-1.71.6-1.4
Reaction time omissions0.71.01.61.3-1.31.0-1.0-1.1-1.0-0.8-0.8-1.1-0.9-1.1-0.90.7-0.7
Reaction time false alarm rate0.10.10.70.9-0.00.5-0.2-0.1-0.00.20.3-0.10.10.10.00.60.4
Reaction time premature initiation rate0.71.01.5-0.70.9-0.81.01.21.11.00.91.01.21.01.2-0.51.0
Reaction time premature initiations1.32.32.9-1.51.4-1.51.61.71.61.51.41.61.71.51.7-1.31.4
Std. dev. reaction times0.00.10.30.6-0.30.4-0.3-0.3-0.2-0.1-0.0-0.1-0.3-0.2-0.20.40.0
Reaction time trials completed0.61.22.8-1.71.0-1.41.10.91.00.90.81.00.90.90.9-1.40.6
Reaction time trials AUC0.81.53.5-1.91.2-1.51.31.11.11.11.01.11.11.11.1-1.60.7
Run reversals in cocaine runway, females0.20.20.50.2-0.40.4-0.5-0.4-0.5-0.4-0.5-0.6-0.4-0.7-0.40.3-0.7
Run reversals in cocaine runway, males0.10.10.2-0.30.3-0.20.20.50.20.30.40.10.10.10.10.00.1
Latency to leave start box in cocaine runway1.61.85.52.3-2.01.6-1.3-1.7-1.1-1.2-1.0-0.8-0.9-1.0-0.91.2-0.3
Latency to leave start box in cocaine runway, F2.42.73.91.6-1.91.6-1.6-2.0-1.6-1.8-1.6-1.5-1.6-1.8-1.61.4-1.4
Latency to leave start box in cocaine runway, M0.60.64.02.0-1.30.8-0.4-0.5-0.10.0-0.00.20.20.20.20.40.9
Std. dev. time between licks in bursts1.52.12.51.0-1.41.3-1.5-1.6-1.5-1.5-1.6-1.6-1.4-1.6-1.41.1-1.6
Total sessions with >9 infusions0.40.52.01.4-0.61.0-0.6-0.4-0.4-0.3-0.2-0.3-0.4-0.3-0.41.40.3
Short access day 1 total inactive lever presses2.43.16.4-0.31.3-1.21.71.51.91.92.12.02.02.02.0-0.92.5
Short access day 10 total inactive lever presses0.20.41.70.8-1.30.6-0.5-1.2-0.5-0.4-0.5-0.4-0.4-0.4-0.40.3-0.3
Short access day 1 total infusions0.30.41.80.9-0.40.9-0.7-0.4-0.5-0.4-0.2-0.6-0.5-0.6-0.51.3-0.0
Short access day 10 total infusions0.20.21.10.80.20.7-0.40.2-0.2-0.1-0.0-0.2-0.4-0.2-0.31.00.3
Short access total infusions0.91.13.21.3-0.61.4-1.1-0.6-1.0-0.8-0.6-1.0-1.1-1.0-1.01.8-0.4
Short access day 1 locomotion0.40.40.9-0.51.0-0.30.61.00.60.60.80.60.60.60.70.20.8
Short access day 10 total locomotion0.00.00.1-0.10.0-0.00.10.20.10.20.20.10.10.10.10.10.2
Short access total locomotion0.10.10.60.6-0.10.4-0.10.20.10.30.40.10.10.10.10.80.6
One hour access (0.3 mA shock)0.00.10.30.3-0.00.00.1-0.00.20.50.40.20.10.20.10.10.4
Compulsive drug intake0.30.41.3-0.4-0.40.1-0.5-0.7-0.6-0.5-0.5-0.8-0.7-0.8-0.8-0.1-1.1
One hour access (shock baseline)0.40.61.90.40.4-0.20.60.60.81.11.00.90.80.90.80.01.4
Social response proportion0.00.00.1-0.1-0.0-0.0-0.00.1-0.1-0.2-0.2-0.1-0.1-0.1-0.20.0-0.2
Social responses1.31.76.0-2.41.6-1.61.31.41.10.91.00.90.90.80.8-1.50.3
Social time2.53.35.0-1.72.1-1.61.92.21.91.81.81.91.91.81.8-1.21.8
Soleus weight0.51.41.91.2-1.11.3-1.2-1.1-1.2-1.2-1.2-1.3-1.2-1.2-1.21.4-1.1
Bone: stiffness0.10.10.70.8-0.40.6-0.3-0.2-0.2-0.1-0.1-0.0-0.3-0.0-0.30.70.2
Tibialis anterior weight0.72.52.9-1.61.6-1.71.71.51.61.61.61.51.71.61.7-1.61.3
Time to tail flick, vehicle, before self-admin0.80.81.7-0.1-0.90.6-0.8-1.1-0.9-0.9-0.9-1.1-1.0-1.1-0.90.6-1.3
Time to tail flick, vehicle, after self-admin0.60.91.7-0.1-0.70.5-0.8-0.9-0.9-1.2-1.2-1.1-1.0-1.1-0.90.4-1.3
Time to tail flick, test, before self-admin0.10.10.2-0.10.2-0.20.30.30.30.40.30.30.40.30.2-0.10.2
Time to tail flick, test, after self-admin0.20.20.3-0.40.4-0.50.50.40.40.50.50.40.50.50.5-0.50.3
Delta time to tail flick, vehicle, before/after SA0.40.30.5-0.20.6-0.50.60.60.60.40.40.70.70.60.7-0.60.7
Delta time to tail flick, test, before/after SA0.00.00.10.1-0.10.2-0.2-0.1-0.2-0.2-0.1-0.2-0.3-0.2-0.10.2-0.2
Tibia length0.51.42.91.7-1.31.4-1.2-1.1-1.1-1.0-1.1-0.9-1.0-0.9-1.11.5-0.8
Ambulatory time before self-admin1.01.51.90.6-0.91.1-1.2-1.2-1.3-1.2-1.2-1.4-1.3-1.4-1.31.2-1.4
Ambulatory time after self-admin0.00.00.0-0.2-0.20.00.0-0.10.00.10.00.10.00.0-0.1-0.00.0
Bone: tissue strength0.30.30.80.3-0.90.5-0.5-0.8-0.6-0.5-0.6-0.5-0.5-0.5-0.50.4-0.6
Total heroin consumption1.82.15.8-2.41.8-1.51.41.71.31.41.31.11.21.11.0-1.30.7
Bone: trabecular number0.30.62.8-1.50.9-1.10.50.50.30.20.40.30.10.10.1-1.7-0.1
Bone: trabecular spacing0.00.00.10.4-0.30.10.0-0.20.10.10.10.20.10.10.20.10.2
Bone: trabecular thickness0.00.00.1-0.30.30.00.10.20.10.0-0.0-0.10.00.1-0.00.4-0.2
Bone: trabecular tissue density0.00.00.10.0-0.1-0.10.1-0.30.10.10.10.10.10.10.1-0.30.1
Water consumed over 24 hours2.83.85.42.2-2.32.2-2.0-2.0-1.9-1.8-1.8-1.8-1.9-1.8-1.82.1-1.5
Number of responses in last shaping day0.10.10.50.10.30.00.20.50.30.70.70.20.20.20.30.30.5