Hub : Genes

Gm2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Gm2a 0.52 0.23 7.4e-10 0.06 0.08 0.07 0.06 2.8e-07 8.8e-09 2.4e-08 3.7e-07
2 Brain mRNA stability Gm2a 0.1 0.1 5.5e-05 0.04 0.04 0.04 0.04 6.9e-05 2.7e-04 1.3e-04 7.1e-05
3 Adipose gene expression Gm2a 0.64 0.14 0.0e+00 0.3 0.33 0.33 0.3 1.3e-33 5.9e-38 9.4e-38 3.5e-34
4 pVTA gene expression Gm2a 0.17 0.11 6.7e-16 0.16 0.19 0.18 0.18 3.2e-13 3.3e-15 1.7e-14 1.7e-14
5 PL mRNA stability Gm2a 0.06 0.05 1.9e-08 0.06 0.06 0.06 0.06 6.4e-07 6.9e-07 1.6e-07 3.3e-07
6 Liver gene expression Gm2a 0.07 0.06 8.6e-07 0.03 0.04 0.03 0.03 1.5e-04 5.3e-05 2.5e-04 1.3e-04
7 Brain gene expression Gm2a 0.18 0.1 0.0e+00 0.22 0.22 0.22 0.23 1.1e-20 3.7e-20 3.2e-20 6.4e-21
8 PL gene expression Gm2a 0.12 0.1 1.8e-11 0.1 0.1 0.09 0.1 1.5e-10 6.4e-11 3.4e-10 4.7e-11
9 IL mRNA stability Gm2a 0.12 0.11 8.2e-03 0.03 0.01 0.02 0.01 5.3e-02 1.6e-01 1.3e-01 1.8e-01
10 IC gene expression Gm2a 0.38 0.17 6.1e-11 0.23 0.22 0.23 0.22 5.7e-10 8.4e-10 6.7e-10 1.5e-09
11 BLA gene expression Gm2a 0.23 0.13 7.1e-14 0.26 0.24 0.26 0.25 3.4e-14 9.9e-13 7.8e-14 2.5e-13
12 NAcc gene expression Gm2a 0.11 0.07 0.0e+00 0.12 0.12 0.12 0.12 4.0e-18 1.6e-17 3.5e-17 1.3e-17
13 Liver mRNA stability Gm2a 0.28 0.19 6.9e-04 0.01 0.03 0.01 0.01 1.9e-02 2.1e-04 6.0e-02 1.2e-02
14 IC mRNA stability Gm2a 0.33 0.18 1.6e-05 0.1 0.1 0.1 0.09 8.7e-05 8.2e-05 7.3e-05 1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.52.3-1.5-0.9-1.00.4-0.50.30.20.2-0.2-0.1-0.1-0.0-1.40.5
Area under the delay curve0.10.10.20.40.30.4-0.40.3-0.4-0.3-0.40.30.40.40.40.30.3
BMI with tail0.20.53.0-1.7-1.0-0.50.1-0.4-0.2-0.3-0.30.60.30.60.3-0.41.3
BMI without tail0.20.92.10.10.60.8-0.90.7-1.0-1.1-1.11.20.91.01.00.81.4
Body weight0.83.34.81.11.21.8-1.81.5-1.9-1.9-2.02.11.82.01.82.02.2
Weight adjusted by age0.00.10.50.70.70.2-0.20.5-0.2-0.2-0.20.20.10.2-0.00.2-0.3
Bone surface0.00.00.2-0.30.0-0.0-0.10.2-0.1-0.2-0.20.20.10.20.3-0.20.4
Bone volume0.40.92.9-1.7-1.2-1.20.8-0.90.70.60.6-0.6-0.6-0.5-0.5-1.50.1
Breakpoint value in progressive ratio session0.71.32.0-1.0-1.1-0.91.1-1.21.11.31.3-1.1-1.2-1.2-1.0-0.7-1.4
Number of licking bursts0.10.41.60.91.30.7-0.50.7-0.4-0.3-0.30.40.40.30.40.8-0.1
Context. condit. distance diff. score0.10.10.5-0.5-0.2-0.3-0.1-0.0-0.2-0.3-0.20.10.40.30.4-0.70.5
Locomotion velocity, session 10.10.10.30.5-0.10.10.1-0.10.10.20.2-0.2-0.3-0.2-0.30.1-0.5
Locomotion distance, session 10.20.30.50.20.10.5-0.60.3-0.6-0.6-0.60.60.60.70.60.60.7
Locomotion velocity, session 20.81.01.31.11.11.0-1.11.1-1.0-1.0-1.01.00.91.00.90.80.8
Locomotion distance, session 20.50.71.81.20.81.1-0.90.7-0.8-0.7-0.80.80.60.70.61.30.4
Locomotion velocity, session 32.73.13.81.31.71.6-1.81.7-1.9-1.9-1.92.01.81.91.81.31.9
Locomotion distance, session 31.92.23.10.91.11.2-1.61.3-1.6-1.7-1.61.71.71.81.70.71.7
Stereotopy head waving bouts, day 30.20.30.80.1-0.3-0.00.4-0.50.50.60.6-0.6-0.6-0.5-0.50.5-0.9
Stereotopy head waving duration, day 31.72.12.8-0.9-1.4-1.11.5-1.61.61.61.6-1.6-1.6-1.6-1.6-0.5-1.7
Locomotion velocity, session 70.10.10.7-0.8-0.2-0.40.10.0-0.0-0.1-0.10.10.20.20.2-0.50.5
Locomotion distance, session 70.10.10.3-0.5-0.5-0.30.4-0.50.40.30.3-0.3-0.3-0.4-0.3-0.1-0.1
Stereotopy head waving bouts, day 70.20.20.3-0.3-0.3-0.40.4-0.50.50.50.5-0.5-0.4-0.4-0.4-0.3-0.6
Stereotopy head waving duration, day 71.01.22.4-0.4-0.8-0.81.1-1.11.21.31.3-1.3-1.3-1.2-1.2-0.6-1.5
Locomotion velocity, session 82.32.73.71.31.91.4-1.71.9-1.8-1.7-1.71.71.71.81.70.81.7
Locomotion distance, session 80.81.21.40.80.91.0-1.11.0-1.2-1.2-1.21.21.21.21.20.91.1
Degree of sensitization distance2.62.83.9-1.2-1.4-1.31.8-1.61.91.91.8-1.8-1.8-2.0-1.9-0.6-1.8
Degree of sensitization stereotypy0.10.10.1-0.2-0.2-0.30.3-0.30.30.30.3-0.2-0.3-0.3-0.2-0.2-0.3
Conditioned locomotion0.70.82.01.41.31.1-0.80.9-0.7-0.7-0.80.70.70.70.71.30.2
Cocaine response after cond. corrected0.20.31.6-1.2-0.6-0.80.4-0.30.30.10.2-0.3-0.1-0.1-0.0-1.00.2
Cocaine response after cond. not corrected1.11.64.5-2.1-1.6-1.71.3-1.21.10.90.9-1.0-1.0-0.9-0.9-1.7-0.4
Cocaine response before conditioning2.53.14.7-1.9-2.2-1.81.8-1.91.81.71.6-1.5-1.9-1.6-1.8-1.5-1.2
Saline control response1.21.62.6-1.5-1.4-1.31.4-1.21.31.31.0-0.9-1.6-1.2-1.5-0.9-0.7
Bone: connectivity density0.10.10.4-0.6-0.3-0.40.2-0.20.10.10.2-0.1-0.1-0.1-0.1-0.60.2
Bone: cortical apparent density0.60.91.6-1.2-1.2-1.21.0-1.00.90.80.9-0.9-0.7-0.9-0.7-1.3-0.6
Bone: cortical area0.71.11.41.11.11.1-1.11.2-1.0-1.0-1.00.91.10.91.10.90.8
Bone: cortical porosity0.20.30.60.20.50.3-0.50.6-0.6-0.5-0.50.60.50.60.5-0.10.7
Bone: cortical porosity0.60.61.6-0.9-0.8-1.00.8-0.60.70.70.8-0.8-0.7-0.6-0.8-1.3-0.4
Bone: cortical thickness0.40.70.90.70.90.9-0.90.9-0.9-0.9-0.80.80.90.81.00.70.8
Bone: cortical thickness0.10.10.20.1-0.3-0.00.2-0.30.30.30.3-0.3-0.2-0.4-0.20.2-0.4
Bone: cortical tissue density0.71.21.9-1.3-1.4-1.31.1-1.11.01.01.0-1.0-0.8-1.0-0.8-1.4-0.7
Condit. Reinf. active minus inactive responses0.20.30.6-0.00.10.3-0.50.2-0.5-0.6-0.60.60.60.60.60.30.8
Condit. Reinf. active-inactive response ratio0.91.01.30.60.80.9-1.00.7-1.0-1.1-1.11.11.11.11.10.91.1
Condit. Reinf. active responses0.00.10.2-0.1-0.5-0.10.2-0.40.20.20.1-0.1-0.2-0.2-0.20.1-0.2
Condit. Reinf. inactive responses1.52.02.6-0.9-1.4-1.21.5-1.41.51.51.5-1.4-1.6-1.6-1.5-1.0-1.5
Incentive salience index mean1.21.52.11.11.01.3-1.31.0-1.3-1.3-1.31.31.31.21.31.41.2
Condit. Reinf. lever presses2.84.26.72.52.12.4-2.11.9-2.0-1.9-2.01.91.81.81.92.61.4
Condit. Reinf. active minus inactive responses0.81.24.1-2.0-1.3-1.51.2-1.11.00.70.7-0.8-0.9-0.8-0.8-1.5-0.1
Condit. Reinf. active-inactive response ratio0.00.10.3-0.5-0.1-0.1-0.10.1-0.2-0.3-0.40.20.20.30.2-0.10.5
Condit. Reinf. active responses1.82.64.5-2.1-1.7-1.91.7-1.51.61.51.5-1.5-1.6-1.5-1.5-1.8-0.9
Condit. Reinf. inactive responses3.34.85.6-2.1-2.0-2.32.3-2.12.32.32.3-2.2-2.4-2.3-2.3-2.1-1.9
Condit. Reinf. lever presses0.30.51.8-1.3-0.7-1.00.8-0.40.60.50.5-0.5-0.6-0.4-0.6-1.0-0.0
Condit. Reinf. lever reinforcers received1.92.75.7-2.4-1.7-2.01.7-1.51.61.41.4-1.5-1.5-1.4-1.4-2.0-0.7
Conditioned reinforcement - actives0.10.20.40.40.30.4-0.40.5-0.4-0.1-0.00.60.60.60.60.60.2
Conditioned reinforcement - inactives0.20.51.3-0.3-0.6-0.50.7-0.60.81.01.0-0.7-0.5-0.7-0.5-0.2-1.1
Conditioned locomotion0.10.10.3-0.3-0.2-0.30.4-0.30.40.60.6-0.2-0.3-0.2-0.4-0.1-0.4
Patch foraging indifference point 0 sec2.26.311.0-3.3-2.9-2.82.6-2.62.42.32.2-2.2-2.4-2.3-2.5-2.6-1.4
Patch foraging indifference point AUC0.00.00.1-0.3-0.3-0.10.1-0.20.0-0.1-0.1-0.0-0.1-0.1-0.1-0.10.3
Delay disc. indifference point, 0s delay0.00.00.10.30.40.1-0.10.2-0.0-0.0-0.00.00.1-0.10.10.1-0.1
Delay disc. indifference point, 16s delay0.00.00.2-0.4-0.2-0.20.2-0.10.10.10.0-0.10.0-0.0-0.1-0.20.1
Delay disc. indifference point, 2s delay1.11.21.80.70.91.0-1.11.1-1.2-1.2-1.31.31.21.31.10.81.3
Delay disc. indifference point, 24s delay0.00.10.20.20.40.2-0.20.3-0.2-0.2-0.30.20.40.40.30.20.1
Delay disc. indifference point, 4s delay1.01.11.9-0.3-0.7-0.81.0-1.11.11.21.1-1.2-1.1-1.2-1.2-0.8-1.4
Delay disc. indifference point, 8s delay0.30.50.70.90.60.8-0.80.5-0.7-0.7-0.70.70.70.80.70.80.6
Indifference point function ln k0.20.50.90.00.30.5-0.70.6-0.7-0.7-0.70.90.80.80.90.70.9
Indifference point function log k0.20.50.90.00.30.5-0.70.6-0.7-0.7-0.70.90.80.80.90.70.9
Patch foraging total patch changes 0 sec2.26.510.4-3.2-2.9-2.72.6-2.72.52.42.3-2.3-2.5-2.4-2.6-2.5-1.6
Patch foraging total patch changes 12 sec5.67.58.7-2.7-2.9-2.82.8-2.82.82.72.6-2.7-3.0-2.8-2.9-2.6-2.2
Patch foraging total patch changes 18 sec1.22.84.2-1.5-1.5-1.61.7-1.71.71.61.4-1.6-2.0-1.8-2.1-1.6-1.3
Patch foraging total patch changes 24 sec1.75.98.5-2.7-2.5-2.82.5-2.52.32.22.0-2.3-2.6-2.2-2.7-2.9-1.5
Patch foraging total patch changes 6 sec4.06.88.9-2.9-3.0-2.72.7-2.92.62.52.4-2.4-2.6-2.5-2.7-2.6-1.8
Patch foraging time to switch 0 sec0.20.82.60.2-0.2-0.50.8-0.50.91.21.1-1.1-1.0-1.0-0.9-0.6-1.6
Patch foraging water rate 0 sec0.20.92.4-0.00.60.7-0.90.8-1.0-1.1-1.11.21.01.00.90.71.6
Patch foraging water rate 12 sec0.10.50.70.90.60.8-0.80.5-0.7-0.8-0.80.70.60.60.60.80.6
Patch foraging water rate 18 sec0.61.32.1-1.0-1.3-1.01.2-1.51.21.11.2-1.1-1.2-1.2-1.2-0.7-1.2
Patch foraging water rate 24 sec0.60.82.6-1.6-1.3-1.00.9-1.20.80.70.7-0.5-0.7-0.6-0.7-0.7-0.2
Patch foraging water rate 6 sec1.72.43.92.01.91.8-1.61.6-1.5-1.4-1.41.51.41.41.31.80.9
Seeking ratio, delayed vs. immediate footshock0.71.01.6-1.3-1.1-1.21.1-0.91.00.80.8-0.9-0.9-0.8-0.8-1.2-0.6
Distance traveled before self-admin1.02.12.61.01.21.5-1.51.3-1.5-1.5-1.51.61.61.61.51.61.4
Distance traveled after self-admin0.00.00.10.30.30.3-0.20.1-0.2-0.1-0.10.00.10.10.10.4-0.2
Extensor digitorum longus weight0.31.01.3-1.1-1.0-1.01.1-0.91.11.11.1-0.9-1.1-1.1-1.0-0.7-1.0
Bone: elastic displacement0.10.21.0-0.80.3-0.50.10.20.0-0.10.00.10.10.10.1-1.00.4
Bone: elastic work0.70.92.10.41.50.6-0.81.3-0.9-1.0-0.90.91.11.01.10.11.0
Bone: endosteal estimation0.51.21.81.31.11.2-1.21.0-1.1-1.1-1.01.11.11.01.11.20.7
Bone: endosteal perimeter0.92.13.71.91.71.7-1.51.5-1.4-1.3-1.31.41.21.21.31.70.8
Epididymis fat weight0.10.51.40.20.30.4-0.70.7-0.8-0.8-0.70.80.81.00.7-0.11.2
Delta time in closed arm before/after self-admin0.30.31.0-1.0-1.0-0.70.4-0.70.40.10.2-0.2-0.2-0.2-0.2-0.60.2
Delta time in open arm before/after self-admin0.30.30.90.71.00.8-0.60.8-0.5-0.2-0.30.40.50.40.40.8-0.1
Diff in mean of infusions in LGA sessions0.20.31.9-1.4-0.9-0.50.2-0.70.10.0-0.10.10.00.10.1-0.60.3
Delay discount exponential model param0.10.10.1-0.4-0.3-0.30.3-0.20.30.30.3-0.3-0.4-0.4-0.3-0.3-0.3
Extinction: sum of active levers before priming0.00.00.3-0.1-0.10.3-0.2-0.0-0.1-0.10.00.10.20.10.30.6-0.2
Active lever presses in extinction session 61.71.74.1-2.0-1.6-1.41.3-1.41.21.21.3-1.1-1.1-1.1-1.0-1.2-0.8
Bone: final force1.42.32.81.41.61.5-1.61.6-1.6-1.5-1.51.51.61.51.71.21.4
Bone: final moment1.32.12.61.31.61.4-1.51.5-1.5-1.5-1.51.41.61.41.61.21.3
Food consumed during 24 hour testing period3.77.58.52.22.92.7-2.82.9-2.8-2.8-2.92.92.62.82.82.32.7
Glucose0.00.10.10.20.40.2-0.20.3-0.2-0.3-0.30.40.10.30.10.20.3
Heart weight1.83.04.01.41.51.7-1.81.6-1.8-1.7-1.71.81.92.01.81.42.0
Delay discount hyperbolic model param0.00.00.1-0.3-0.2-0.20.2-0.10.20.10.2-0.1-0.2-0.2-0.1-0.2-0.1
Intermittent access intake day 1-15 change0.20.92.61.20.30.10.5-0.20.81.11.1-1.1-1.1-1.1-1.00.1-1.6
Intermittent access intake escalation0.21.02.81.10.2-0.10.6-0.30.91.21.2-1.2-1.2-1.2-1.1-0.1-1.7
Intermittent access intake escalation 21.01.74.00.6-0.1-0.61.1-0.51.31.61.6-1.6-1.6-1.6-1.6-0.7-2.0
Intermitt. access day 1 inactive lever presses0.00.51.6-0.2-0.6-0.60.7-0.40.70.91.0-0.7-0.5-0.7-0.5-0.7-1.3
Intermitt. access day 15 inactive lever presses0.00.00.1-0.1-0.1-0.10.1-0.20.10.20.1-0.1-0.1-0.1-0.10.1-0.3
Intermitt. access escalation Index0.10.31.1-1.0-0.2-0.0-0.2-0.2-0.4-0.4-0.40.70.60.70.60.21.0
Intermittent access day 1 total infusions0.10.20.70.40.10.6-0.50.2-0.4-0.2-0.30.50.70.50.60.80.3
Intermittent access day 15 total infusions0.10.21.01.00.30.5-0.10.10.10.50.5-0.2-0.1-0.2-0.10.7-0.7
Intermittent access terminal intake (last 3 days)0.20.30.90.90.20.30.1-0.00.30.70.7-0.4-0.3-0.4-0.30.5-1.0
Intermittent access total infusions0.20.21.11.00.30.8-0.40.2-0.30.10.10.20.40.20.31.0-0.2
Intermittent access day 1 locomotion0.10.10.40.50.20.4-0.30.0-0.20.10.10.30.40.30.30.6-0.2
Intermittent access day 15 total locomotion1.03.96.2-0.9-1.4-1.62.0-1.72.12.52.4-2.1-2.3-2.1-2.4-1.2-2.2
Intermittent access total locomotion2.32.84.7-0.6-1.3-1.21.6-1.71.82.12.1-1.8-1.8-1.8-1.8-0.8-2.2
Intermittent access standard deviation0.10.72.41.61.41.0-0.81.2-0.7-0.4-0.60.50.40.50.40.70.3
Left kidney weight3.024.528.24.35.04.9-5.05.1-5.0-5.1-5.35.15.05.14.84.64.8
Right kidney weight2.920.322.74.04.64.5-4.64.6-4.6-4.6-4.84.64.54.74.44.04.4
Cocaine induced anxiety0.00.00.2-0.3-0.2-0.10.1-0.20.10.30.40.1-0.10.1-0.1-0.1-0.0
Post-drug Anxiety0.10.20.3-0.1-0.1-0.30.4-0.40.50.40.5-0.4-0.5-0.4-0.5-0.1-0.4
Baseline Anxiety0.20.40.90.60.90.7-0.60.6-0.5-0.8-0.80.40.50.40.50.90.4
Tail length0.95.07.72.82.72.4-2.32.4-2.2-2.3-2.32.02.02.02.02.21.5
Length with tail1.25.58.02.82.52.6-2.42.4-2.3-2.3-2.42.22.12.22.12.61.6
Length without tail0.21.11.60.70.51.0-1.00.9-1.1-1.1-1.11.31.21.21.11.21.2
Times rat made contact with spout1.01.22.11.31.41.2-1.11.2-1.1-1.0-1.00.91.01.01.01.10.7
Lifetime Intake0.60.82.41.30.71.2-0.90.5-0.8-0.5-0.40.70.90.70.81.50.3
Liver weight, left0.10.10.3-0.0-0.5-0.30.4-0.30.40.30.2-0.4-0.6-0.5-0.5-0.3-0.3
Liver weight, right0.00.00.3-0.3-0.0-0.0-0.10.3-0.1-0.1-0.20.10.10.20.3-0.20.5
Locomotor activity1.32.02.4-1.5-1.5-1.51.5-1.31.51.41.5-1.5-1.2-1.3-1.2-1.4-1.3
Locomotor testing distance2.46.010.7-3.3-2.9-2.92.6-2.32.42.22.2-2.2-2.2-2.1-2.1-2.9-1.4
Locomotor testing rearing1.35.013.0-3.6-2.7-2.92.3-2.12.01.71.7-1.8-1.7-1.6-1.7-3.0-0.6
Locomotion in novel chamber0.10.10.50.30.1-0.00.1-0.20.20.30.3-0.3-0.4-0.3-0.2-0.0-0.7
Locomotion in novel chamber post-restriction0.10.20.7-0.8-0.8-0.50.4-0.50.30.10.1-0.3-0.3-0.3-0.4-0.50.3
Fecal boli incidents, locomotor time 10.10.21.2-1.1-0.5-0.70.5-0.50.40.10.0-0.2-0.3-0.2-0.3-0.7-0.1
Change in fecal boli incidents, locomotor task1.92.05.22.32.01.7-1.41.7-1.2-1.0-0.91.01.20.91.11.60.5
Time >=10cm from walls, locomotor time 12.83.54.0-1.8-1.6-1.92.0-1.72.01.91.9-2.0-1.9-1.9-1.9-1.7-1.8
Bouts of movement, locomotor time 10.40.50.9-0.9-0.8-0.80.7-0.80.70.60.6-0.6-0.5-0.6-0.6-0.7-0.6
Total resting periods, locomotor time 10.30.40.7-0.8-0.6-0.70.7-0.70.60.60.6-0.6-0.5-0.5-0.5-0.6-0.7
Rest time, locomotor task time 10.30.51.0-1.0-0.7-0.80.7-0.70.70.60.5-0.6-0.7-0.4-0.7-0.7-0.7
Distance moved, locomotor task time 10.00.10.30.50.60.4-0.40.4-0.4-0.2-0.10.30.30.30.40.30.5
Vertical activity count, locomotor time 10.10.40.7-0.6-0.8-0.60.6-0.80.60.80.8-0.7-0.6-0.7-0.5-0.5-0.3
Time >=10cm from walls, locomotor time 20.00.10.4-0.7-0.2-0.30.1-0.00.0-0.1-0.10.1-0.00.20.1-0.30.4
Bouts of movement, locomotor time 20.00.10.20.4-0.1-0.00.2-0.10.30.30.3-0.3-0.4-0.5-0.40.0-0.5
Total resting periods, locomotor time 20.00.10.20.3-0.1-0.10.3-0.10.40.30.4-0.3-0.4-0.5-0.4-0.0-0.5
Rest time, locomotor task time 21.32.32.7-1.5-1.5-1.51.6-1.41.61.61.5-1.4-1.5-1.5-1.6-1.4-1.5
Distance moved, locomotor task time 20.10.10.4-0.6-0.3-0.40.2-0.20.10.10.1-0.2-0.20.0-0.0-0.50.6
Vertical activity count, locomotor time 20.00.10.2-0.5-0.5-0.40.3-0.40.20.20.2-0.3-0.2-0.1-0.1-0.30.2
Light reinforcement 10.73.05.6-2.4-2.0-1.91.8-1.91.61.61.5-1.5-1.7-1.6-1.6-1.8-1.0
Light reinforcement 20.00.10.3-0.5-0.3-0.30.1-0.20.00.1-0.10.2-0.10.00.0-0.40.4
Bone: marrow area0.61.52.21.51.31.4-1.31.2-1.3-1.2-1.21.21.21.21.31.30.8
Bone: maximum diameter1.53.03.81.92.01.9-1.82.0-1.7-1.7-1.71.61.61.61.61.71.4
Bone: maximum force0.51.01.41.01.11.0-1.01.0-1.0-1.0-1.00.91.10.91.20.90.8
Bone: maximum moment0.50.91.30.91.01.0-1.00.9-1.0-1.0-0.90.81.10.81.10.90.8
Mean time between licks in bursts0.53.13.51.81.81.8-1.91.8-1.9-1.8-1.81.81.81.81.81.51.5
Mean num. licks in bursts0.00.10.6-0.5-0.8-0.40.3-0.40.20.20.2-0.2-0.2-0.1-0.3-0.50.1
Cd content in liver1.41.52.1-0.9-0.9-1.11.4-1.01.41.41.3-1.3-1.4-1.4-1.4-0.7-1.4
Co content in liver0.30.31.41.00.70.8-0.40.5-0.3-0.2-0.10.40.40.20.41.2-0.3
Cu content in liver0.10.10.40.50.70.4-0.20.7-0.2-0.1-0.10.10.10.20.10.4-0.1
Fe content in liver0.00.00.1-0.00.30.0-0.10.4-0.1-0.1-0.10.10.10.20.1-0.20.2
K content in liver11.210.912.83.43.43.6-3.43.3-3.3-3.3-3.43.43.13.23.13.62.6
Mg content in liver2.42.63.71.81.81.8-1.61.6-1.6-1.6-1.71.71.41.51.41.91.1
Mn content in liver0.20.20.70.70.20.40.1-0.20.30.30.2-0.1-0.4-0.4-0.50.9-0.8
Na content in liver1.41.62.51.61.51.4-1.31.4-1.2-1.2-1.21.21.11.21.11.30.8
Rb content in liver1.92.24.5-2.0-1.7-1.81.4-1.51.31.21.3-1.3-1.2-1.1-1.2-2.1-0.8
Se content in liver1.72.03.01.51.71.4-1.51.6-1.4-1.4-1.41.41.41.41.31.11.1
Sr content in liver0.10.10.50.4-0.00.30.0-0.10.10.1-0.00.1-0.2-0.1-0.20.7-0.3
Zn content in liver0.70.81.51.01.20.9-0.91.2-0.8-0.8-0.90.80.60.80.70.90.6
Bone: minimum diameter1.12.12.61.61.51.6-1.51.5-1.4-1.4-1.31.41.61.31.61.51.0
Time in familiar zone, hab. session 16.97.69.5-2.9-2.8-3.12.9-2.62.82.72.8-2.8-2.6-2.6-2.6-3.1-2.3
Time in novel zone, hab. session 14.04.55.31.41.92.0-2.22.2-2.2-2.3-2.32.32.22.22.21.82.3
Total zone transitions, hab. session 10.10.10.3-0.3-0.5-0.30.3-0.60.30.20.2-0.3-0.4-0.3-0.3-0.1-0.3
Total locomotion distance, hab. session 10.60.81.4-0.8-1.2-0.80.9-1.10.90.90.8-0.9-0.9-1.0-0.9-0.4-0.8
Locomotion velocity, hab. session 10.20.20.50.3-0.4-0.00.3-0.70.40.50.4-0.5-0.5-0.6-0.50.4-0.7
Time in familiar zone, hab. session 21.31.41.9-0.8-0.8-1.11.3-1.01.31.31.3-1.3-1.3-1.4-1.4-1.0-1.3
Time in novel zone, hab. session 22.93.24.11.21.51.6-1.91.8-1.9-1.9-1.91.92.02.02.01.32.0
Total zone transitions, hab. session 20.00.10.2-0.2-0.2-0.0-0.2-0.1-0.2-0.3-0.30.30.20.30.2-0.20.4
Total locomotion distance, hab. session 20.30.30.7-0.6-0.8-0.70.5-0.70.50.50.5-0.5-0.5-0.5-0.5-0.8-0.3
Locomotion velocity, hab. session 20.10.10.3-0.3-0.5-0.30.2-0.40.10.10.2-0.2-0.2-0.1-0.1-0.4-0.0
Novel to familiar place preference ratio0.30.31.0-0.8-1.0-0.50.6-0.80.60.50.5-0.5-0.5-0.5-0.4-0.3-0.3
Novelty place preference0.20.20.7-0.6-0.8-0.40.4-0.60.40.40.3-0.3-0.4-0.4-0.3-0.1-0.2
Time in novel zone, NPP test0.10.20.6-0.6-0.8-0.40.4-0.60.40.30.3-0.3-0.3-0.4-0.3-0.1-0.2
Total zone transitions, NPP test0.10.10.20.1-0.4-0.20.2-0.50.30.40.4-0.4-0.4-0.3-0.4-0.0-0.5
Total locomotion distance, NPP test0.10.20.6-0.1-0.8-0.30.4-0.70.40.40.4-0.4-0.5-0.4-0.5-0.1-0.5
Locomotion velocity, NPP test0.10.20.6-0.1-0.8-0.30.3-0.70.40.40.4-0.4-0.5-0.4-0.4-0.0-0.4
Intraocular pressure0.20.30.9-0.9-0.8-0.60.4-0.60.40.40.5-0.3-0.1-0.2-0.1-0.5-0.2
Delta distance traveled before/after self-admin1.51.62.0-0.9-1.1-1.31.3-1.31.31.21.2-1.4-1.3-1.4-1.3-1.3-1.3
Delta ambulatory time before/after self-admin1.42.53.1-1.1-1.3-1.51.6-1.51.71.61.5-1.7-1.7-1.8-1.7-1.5-1.7
Parametrial fat weight2.25.16.22.02.52.3-2.22.4-2.2-2.4-2.52.42.22.12.22.31.8
Pavlov. Cond. lever latency0.30.40.6-0.8-0.7-0.70.7-0.60.60.60.6-0.6-0.6-0.6-0.6-0.6-0.5
Pavlov. Cond. magazine entry latency0.20.20.50.70.50.6-0.50.5-0.4-0.3-0.40.40.40.40.50.50.2
Pavlov. Cond. change in total contacts0.10.10.50.70.20.3-0.20.0-0.10.00.0-0.10.10.10.10.1-0.2
Pavlov. Cond. index score0.30.40.91.00.80.7-0.60.7-0.6-0.4-0.50.40.50.50.50.50.3
Pavlov. Cond. latency score0.30.40.80.90.80.8-0.70.7-0.7-0.6-0.60.60.60.60.60.60.5
Pavlov. Cond. lever contacts0.30.40.80.90.80.8-0.70.7-0.6-0.5-0.50.50.50.60.60.60.4
Pavlov. Cond. magazine entry number0.00.00.1-0.1-0.1-0.00.2-0.20.20.10.1-0.0-0.2-0.2-0.30.3-0.2
Pavlov. Cond. intertrial magazine entries1.41.72.2-1.3-1.5-1.31.4-1.51.41.31.3-1.3-1.2-1.4-1.3-0.9-1.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.90.70.6-0.50.5-0.4-0.3-0.30.20.30.30.40.40.1
Pavlov. Cond. response bias0.10.10.40.60.40.4-0.40.3-0.3-0.2-0.20.10.20.20.30.20.1
Pavlov. Cond. lever latency0.60.92.90.6-0.4-0.30.7-1.00.91.11.1-1.1-1.0-1.2-1.0-0.1-1.7
Pavlov. Cond. magazine entry latency0.50.81.30.30.60.7-0.91.0-0.9-0.9-0.91.01.11.00.90.51.2
Pavlov. Cond. change in total contacts0.00.10.4-0.6-0.2-0.2-0.00.1-0.1-0.2-0.20.20.30.30.2-0.10.6
Pavlov. Cond. index score0.50.71.9-0.10.40.5-0.70.9-0.9-1.0-0.91.01.01.00.90.51.4
Pavlov. Cond. latency score0.60.92.0-0.00.50.6-0.90.9-1.0-1.0-1.01.11.11.11.00.61.4
Pavlov. Cond. lever contacts0.60.92.7-0.60.40.3-0.71.0-0.9-1.0-1.01.11.01.11.00.21.7
Pavlov. Cond. magazine entry number0.10.10.30.20.0-0.00.2-0.20.30.30.2-0.3-0.4-0.4-0.3-0.0-0.6
Pavlov. Cond. intertrial magazine entries1.73.64.5-1.5-1.7-1.82.0-1.92.02.02.0-2.1-2.0-2.1-2.0-1.6-1.9
Pavlov. Cond. lever-magazine prob. diff.0.50.71.7-0.10.40.5-0.70.8-0.9-0.9-0.91.01.01.00.90.61.3
Pavlov. Cond. response bias1.01.33.3-0.10.70.6-1.01.3-1.2-1.3-1.21.31.21.41.20.41.8
Time in closed arm before self-admin0.40.71.00.61.00.8-0.90.9-0.9-0.8-0.90.90.90.91.00.50.7
Time in closed arm after self-admin0.40.41.5-0.5-0.20.1-0.50.2-0.6-0.9-0.90.70.60.70.8-0.11.2
Time in open arm before self-admin0.30.30.90.3-0.3-0.30.5-0.50.60.60.8-0.6-0.6-0.6-0.6-0.2-1.0
Time in open arm after self-admin0.80.83.70.90.40.00.5-0.10.81.21.2-0.9-0.9-1.0-0.90.2-1.9
Bone: periosteal estimation0.92.12.61.61.51.6-1.51.5-1.5-1.4-1.41.41.51.41.51.41.1
Bone: periosteal perimeter0.71.51.91.41.21.4-1.31.2-1.2-1.1-1.11.21.21.11.21.30.9
Bone: post-yield work0.61.11.4-0.7-1.1-0.91.0-1.11.11.11.1-1.2-1.0-1.2-0.9-0.7-1.1
Progressive ratio test 1 active lever presses0.10.10.40.5-0.10.30.0-0.20.20.50.5-0.20.0-0.2-0.00.6-0.6
Progressive ratio test 1 breakpoint0.10.20.50.4-0.20.20.1-0.40.30.70.7-0.3-0.1-0.3-0.20.5-0.7
Progressive ratio test 1 inactive lever presses0.30.81.71.31.01.1-0.91.0-0.8-0.5-0.50.71.00.71.01.30.0
Progressive ratio test 2 active lever presses0.10.20.60.40.10.10.2-0.30.40.60.6-0.4-0.3-0.4-0.40.5-0.8
Progressive ratio test 2 breakpoint0.20.30.90.3-0.1-0.00.4-0.40.60.80.8-0.6-0.5-0.6-0.60.3-1.0
Progressive ratio test 2 inactive lever presses0.00.00.10.30.00.00.10.10.20.40.4-0.2-0.1-0.2-0.20.1-0.4
Incentive Sensitization - Responses0.30.81.1-0.7-0.6-0.81.0-0.81.01.01.1-1.0-0.9-1.0-1.0-0.5-1.0
Incentive Sensitization - Breakpoint0.30.70.9-0.6-0.5-0.70.9-0.70.90.90.9-1.0-0.8-1.0-0.9-0.5-0.9
Sum of active levers in priming session hrs 5-60.20.20.7-0.9-0.6-0.30.4-0.50.30.40.4-0.3-0.3-0.2-0.3-0.2-0.3
Progressive ratio0.20.51.5-0.2-0.9-0.50.7-1.20.70.60.6-0.8-0.8-0.8-0.9-0.3-0.6
Food seeking constrained by brief footshock0.10.10.2-0.4-0.2-0.40.4-0.50.30.30.3-0.3-0.3-0.3-0.3-0.4-0.3
Seeking ratio, punishment vs. effort0.30.61.30.10.90.5-0.71.1-0.8-0.7-0.80.80.90.80.90.20.8
Retroperitoneal fat weight0.83.85.61.01.41.7-2.01.9-2.1-2.1-2.22.22.02.32.01.32.4
Reaction time number correct0.31.22.9-1.7-1.1-1.41.1-1.01.01.00.9-1.0-0.9-1.0-0.9-1.4-0.5
Reaction time mean minus median0.10.41.11.10.70.8-0.60.6-0.5-0.3-0.30.40.50.40.40.90.2
Reaction time mean minus median AUC0.00.00.30.50.20.2-0.00.00.10.20.3-0.2-0.0-0.1-0.20.3-0.2
Reaction time num false alarms0.20.30.6-0.3-0.8-0.40.5-0.60.60.70.8-0.5-0.6-0.6-0.5-0.3-0.6
Reaction time num false alarms AUC0.30.61.3-0.2-0.8-0.50.7-0.70.81.11.1-0.7-0.9-0.9-0.8-0.3-1.0
Reaction time trials correct on left0.31.22.9-1.7-1.1-1.41.1-1.01.01.00.9-1.0-0.9-1.0-0.9-1.4-0.5
Reaction time trials on left0.31.12.8-1.7-1.0-1.41.1-0.91.00.90.8-1.0-0.9-0.9-0.9-1.4-0.5
Reaction time mean0.92.12.51.51.51.6-1.51.5-1.5-1.4-1.21.41.51.41.51.51.1
Reaction time mean AUC0.81.93.31.81.51.7-1.41.4-1.3-1.2-1.11.21.41.21.31.70.7
Median of all reaction times1.72.63.01.61.61.7-1.71.7-1.7-1.6-1.51.61.71.61.71.61.3
Reaction time omissions0.61.01.61.31.31.0-1.01.1-1.0-0.8-0.81.10.91.10.90.70.7
Reaction time false alarm rate0.10.10.70.90.00.5-0.20.1-0.00.20.30.1-0.1-0.1-0.00.6-0.4
Reaction time premature initiation rate0.61.01.5-0.7-0.9-0.81.0-1.21.11.00.9-1.0-1.2-1.0-1.2-0.5-1.1
Reaction time premature initiations0.82.42.9-1.5-1.4-1.51.6-1.71.61.51.4-1.6-1.7-1.5-1.7-1.3-1.5
Std. dev. reaction times0.00.10.30.60.30.4-0.30.3-0.2-0.1-0.00.10.30.20.20.40.1
Reaction time trials completed0.31.12.8-1.7-1.0-1.41.1-0.91.00.90.8-1.0-0.9-0.9-0.9-1.4-0.5
Reaction time trials AUC0.41.53.5-1.9-1.2-1.51.3-1.11.11.11.0-1.1-1.1-1.1-1.1-1.6-0.6
Run reversals in cocaine runway, females0.20.20.50.20.40.4-0.50.4-0.5-0.4-0.50.60.40.70.40.30.6
Run reversals in cocaine runway, males0.10.10.2-0.3-0.3-0.20.2-0.50.20.30.4-0.1-0.1-0.1-0.10.0-0.4
Latency to leave start box in cocaine runway1.31.85.52.32.01.6-1.31.7-1.1-1.2-1.00.80.91.00.91.20.5
Latency to leave start box in cocaine runway, F2.22.83.91.61.91.6-1.62.0-1.6-1.8-1.61.51.61.81.61.41.5
Latency to leave start box in cocaine runway, M0.60.64.02.01.30.8-0.40.5-0.10.0-0.0-0.2-0.2-0.2-0.20.4-0.7
Std. dev. time between licks in bursts1.12.12.51.01.41.3-1.51.6-1.5-1.5-1.61.61.41.61.41.11.5
Total sessions with >9 infusions0.40.52.01.40.61.0-0.60.4-0.4-0.3-0.20.30.40.30.41.4-0.2
Short access day 1 total inactive lever presses1.53.05.8-0.3-1.3-1.21.7-1.51.91.92.1-2.0-2.0-2.0-2.0-0.9-2.4
Short access day 10 total inactive lever presses0.10.41.70.81.30.6-0.51.2-0.5-0.4-0.50.40.40.40.40.30.1
Short access day 1 total infusions0.20.41.80.90.40.9-0.70.4-0.5-0.4-0.20.60.50.60.51.30.2
Short access day 10 total infusions0.10.21.10.8-0.20.7-0.4-0.2-0.2-0.1-0.00.20.40.20.31.0-0.3
Short access total infusions0.81.13.21.30.61.4-1.10.6-1.0-0.8-0.61.01.11.01.01.80.6
Short access day 1 locomotion0.30.40.9-0.5-1.0-0.30.6-1.00.60.60.8-0.6-0.6-0.6-0.70.2-0.7
Short access day 10 total locomotion0.00.00.1-0.1-0.0-0.00.1-0.20.10.20.2-0.1-0.1-0.1-0.10.1-0.2
Short access total locomotion0.10.20.60.60.10.4-0.1-0.20.10.30.4-0.1-0.1-0.1-0.10.8-0.8
One hour access (0.3 mA shock)0.00.00.30.30.00.00.10.00.20.50.4-0.2-0.1-0.2-0.10.1-0.3
Compulsive drug intake0.30.41.0-0.40.40.1-0.50.7-0.6-0.5-0.50.80.70.80.8-0.11.0
One hour access (shock baseline)0.20.61.50.4-0.4-0.20.6-0.60.81.11.0-0.9-0.8-0.9-0.80.0-1.2
Social response proportion0.00.00.0-0.10.0-0.0-0.0-0.1-0.1-0.2-0.20.10.10.10.20.00.0
Social responses1.31.76.0-2.4-1.6-1.61.3-1.41.10.91.0-0.9-0.9-0.8-0.8-1.5-0.4
Social time2.13.35.0-1.7-2.1-1.61.9-2.21.91.81.8-1.9-1.9-1.8-1.8-1.2-1.6
Soleus weight0.51.41.91.21.11.3-1.21.1-1.2-1.2-1.21.31.21.21.21.40.9
Bone: stiffness0.10.10.70.80.40.6-0.30.2-0.2-0.1-0.10.00.30.00.30.7-0.1
Tibialis anterior weight0.72.52.9-1.6-1.6-1.71.7-1.51.61.61.6-1.5-1.7-1.6-1.7-1.6-1.3
Time to tail flick, vehicle, before self-admin0.70.92.1-0.10.90.6-0.81.1-0.9-0.9-0.91.11.01.10.90.61.5
Time to tail flick, vehicle, after self-admin0.50.92.7-0.10.70.5-0.80.9-0.9-1.2-1.21.11.01.10.90.41.6
Time to tail flick, test, before self-admin0.10.10.3-0.1-0.2-0.20.3-0.30.30.40.3-0.3-0.4-0.3-0.2-0.1-0.5
Time to tail flick, test, after self-admin0.20.20.3-0.4-0.4-0.50.5-0.40.40.50.5-0.4-0.5-0.5-0.5-0.5-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.2-0.6-0.50.6-0.60.60.40.4-0.7-0.7-0.6-0.7-0.6-0.5
Delta time to tail flick, test, before/after SA0.00.00.10.10.10.2-0.20.1-0.2-0.2-0.10.20.30.20.10.20.3
Tibia length0.51.42.91.71.31.4-1.21.1-1.1-1.0-1.10.91.00.91.11.50.6
Ambulatory time before self-admin0.51.41.90.60.91.1-1.21.2-1.3-1.2-1.21.41.31.41.31.21.2
Ambulatory time after self-admin0.00.00.1-0.20.20.00.00.10.00.10.0-0.1-0.0-0.00.1-0.0-0.3
Bone: tissue strength0.30.30.80.30.90.5-0.50.8-0.6-0.5-0.60.50.50.50.50.40.6
Total heroin consumption1.82.15.8-2.4-1.8-1.51.4-1.71.31.41.3-1.1-1.2-1.1-1.0-1.3-1.0
Bone: trabecular number0.30.62.8-1.5-0.9-1.10.5-0.50.30.20.4-0.3-0.1-0.1-0.1-1.70.4
Bone: trabecular spacing0.00.00.10.40.30.10.00.20.10.10.1-0.2-0.1-0.1-0.20.1-0.3
Bone: trabecular thickness0.00.00.1-0.3-0.30.00.1-0.20.10.0-0.00.1-0.0-0.10.00.40.1
Bone: trabecular tissue density0.00.00.10.00.1-0.10.10.30.10.10.1-0.1-0.1-0.1-0.1-0.3-0.1
Water consumed over 24 hours1.93.75.42.22.32.2-2.02.0-1.9-1.8-1.81.81.91.81.82.11.4
Number of responses in last shaping day0.10.20.60.1-0.30.00.2-0.50.30.70.7-0.2-0.2-0.2-0.30.3-0.8