Hub : Genes

Gls2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XM_039078385.1 0.04 0.03 9.0e-03 0.01 0.01 0.01 0.01 1.6e-02 4.6e-02 3.3e-02 5.2e-02
2 Liver mRNA stability Gls2 0.06 0.04 2.7e-06 0.04 0.04 0.04 0.04 1.1e-05 4.5e-05 7.9e-05 4.6e-05
3 pVTA isoform ratio NM_001270786.1 0.11 0.08 1.5e-03 0.07 0.07 0.06 0.06 7.8e-04 6.9e-04 1.4e-03 8.8e-04
4 Brain isoform ratio NM_001270786.1 0.06 0.05 2.2e-04 0.04 0.03 0.04 0.04 6.1e-05 1.1e-03 2.7e-04 8.1e-05
5 Brain alternative TSS NM_001270787.1 0.04 0.03 9.7e-03 0.02 0.02 0.01 0.02 7.5e-03 9.3e-03 4.9e-02 1.0e-02
6 Brain mRNA stability Gls2 0.04 0.04 3.8e-03 0.02 0.01 0 0.01 1.1e-02 3.9e-02 1.0e-01 4.7e-02
7 IL alternative TSS XM_039078388.1 0.29 0.18 5.0e-03 -0.01 -0.01 0 -0.01 6.3e-01 7.3e-01 3.3e-01 5.6e-01
8 IL alternative TSS XM_039078388.1 0.27 0.17 6.6e-03 -0.01 -0.01 -0.01 -0.01 8.3e-01 8.8e-01 5.1e-01 8.3e-01
9 Brain intron excision ratio chr7_622746_623113 0.05 0.04 5.2e-04 0.02 0.03 0.03 0.03 2.4e-03 1.4e-03 1.3e-03 1.8e-03
10 PL gene expression Gls2 0.19 0.13 2.2e-15 0.12 0.14 0.14 0.14 1.3e-12 5.2e-15 3.6e-15 8.6e-15
11 BLA gene expression Gls2 0.15 0.1 7.1e-07 0.05 0.12 0.09 0.09 8.4e-04 8.7e-07 1.3e-05 2.0e-05
12 OFC gene expression Gls2 0.42 0.19 3.4e-06 0.1 0.24 0.21 0.21 2.8e-03 2.3e-06 9.7e-06 1.1e-05
13 IL alternative TSS NM_138904.2 0.28 0.16 3.7e-03 -0.01 0 -0.01 -0 6.6e-01 2.3e-01 4.9e-01 4.4e-01
14 IL alternative TSS NM_138904.2 0.29 0.16 3.1e-03 -0.01 0.01 0.01 0 5.7e-01 1.9e-01 2.3e-01 3.2e-01
15 Brain gene expression Gls2 0.03 0.03 7.2e-03 0 0.01 0.01 0.01 9.6e-02 4.4e-02 1.9e-02 4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.03.37.2-0.90.9-0.30.9-1.00.82.72.5-0.1-2.22.12.42.52.5-2.3
Area under the delay curve0.10.10.5-0.20.3-0.10.2-0.70.20.20.30.4-0.30.30.40.40.4-0.3
BMI with tail5.116.628.6-5.3-5.3-5.45.2-5.25.3-1.8-2.75.13.1-3.4-2.4-2.3-2.33.0
BMI without tail1.22.53.5-1.7-1.7-1.81.5-1.71.3-1.6-1.91.81.6-1.6-1.3-1.3-1.31.4
Body weight0.83.46.6-2.5-2.1-2.42.1-2.62.0-1.0-1.32.41.7-1.6-1.2-1.1-1.11.3
Weight adjusted by age0.20.20.50.2-0.10.0-0.10.2-0.1-0.7-0.7-0.10.7-0.6-0.7-0.7-0.70.5
Bone surface4.57.819.9-0.81.6-0.00.8-0.60.64.54.1-0.4-3.73.33.73.73.7-3.2
Bone volume4.37.417.3-1.11.5-0.21.1-1.00.84.23.9-0.2-3.43.13.63.73.7-3.2
Breakpoint value in progressive ratio session1.31.43.61.71.51.6-1.81.9-1.8-0.4-0.2-1.6-0.40.60.30.20.2-0.8
Number of licking bursts3.43.96.2-1.7-2.5-1.91.6-1.81.7-2.2-2.51.92.1-2.1-1.9-1.9-1.91.9
Context. condit. distance diff. score0.10.10.2-0.4-0.5-0.50.5-0.40.30.30.10.40.2-0.5-0.4-0.4-0.40.3
Locomotion velocity, session 10.60.71.7-0.80.8-0.30.5-0.80.30.30.40.1-0.71.01.31.31.3-1.2
Locomotion distance, session 11.01.33.2-0.10.90.2-0.0-0.10.01.01.0-0.3-1.51.61.81.81.8-1.4
Locomotion velocity, session 22.63.05.70.62.01.0-0.60.8-0.81.71.9-1.1-1.92.22.32.32.3-2.4
Locomotion distance, session 22.94.07.41.52.31.8-1.51.0-1.41.31.6-1.7-2.12.72.62.62.5-2.3
Locomotion velocity, session 33.23.77.12.62.62.6-2.72.5-2.60.10.6-2.6-1.11.51.01.01.0-1.3
Locomotion distance, session 30.20.21.00.40.20.3-0.60.3-0.5-1.0-0.8-0.40.3-0.0-0.1-0.1-0.10.1
Stereotopy head waving bouts, day 34.14.87.02.52.62.7-2.42.6-2.31.61.8-2.7-2.32.21.71.71.7-1.8
Stereotopy head waving duration, day 32.63.15.52.02.12.1-1.92.3-1.71.31.5-2.1-1.81.71.41.31.3-1.5
Locomotion velocity, session 70.20.20.40.20.20.2-0.00.3-0.10.50.6-0.1-0.40.60.60.60.6-0.7
Locomotion distance, session 70.40.51.20.1-0.9-0.20.10.00.2-1.1-1.00.40.9-0.8-0.9-0.9-0.90.9
Stereotopy head waving bouts, day 71.82.04.40.51.40.9-0.70.5-1.02.12.0-1.1-1.91.61.61.61.6-1.5
Stereotopy head waving duration, day 71.92.34.80.31.60.8-0.50.3-0.92.22.1-1.0-2.01.81.81.81.8-1.8
Locomotion velocity, session 82.53.05.90.72.11.1-0.90.3-0.91.61.8-1.2-1.82.32.32.32.3-2.4
Locomotion distance, session 80.30.50.90.70.80.7-0.70.3-0.60.40.5-0.6-0.70.90.90.90.9-0.7
Degree of sensitization distance0.40.40.9-0.8-1.0-0.80.9-0.81.00.2-0.11.00.2-0.4-0.3-0.3-0.30.3
Degree of sensitization stereotypy0.40.51.5-0.60.2-0.30.4-0.70.01.21.00.1-0.80.60.80.80.8-0.7
Conditioned locomotion1.72.03.3-0.7-1.5-0.90.6-0.70.7-1.5-1.61.21.7-1.8-1.8-1.8-1.81.8
Cocaine response after cond. corrected2.63.04.6-1.0-1.9-1.41.4-0.91.1-1.5-1.71.72.1-2.1-2.0-2.0-2.02.0
Cocaine response after cond. not corrected3.03.35.2-1.1-2.0-1.51.4-1.01.0-1.6-1.81.72.3-2.3-2.2-2.1-2.12.1
Cocaine response before conditioning0.40.50.80.50.80.7-0.70.6-0.70.60.8-0.9-0.90.80.70.70.7-0.8
Saline control response0.30.40.7-0.6-0.6-0.70.5-0.70.4-0.9-0.80.50.8-0.8-0.7-0.6-0.60.6
Bone: connectivity density1.11.73.5-0.60.7-0.20.6-0.60.51.61.5-0.2-1.51.61.81.91.9-1.8
Bone: cortical apparent density1.01.32.9-1.2-1.0-1.41.6-1.31.7-1.1-1.11.31.3-1.0-0.7-0.6-0.60.6
Bone: cortical area1.01.53.6-1.7-0.6-1.41.8-1.31.91.20.91.4-0.80.61.01.11.1-0.7
Bone: cortical porosity0.20.20.5-0.10.0-0.00.10.20.30.20.20.4-0.60.60.70.70.7-0.5
Bone: cortical porosity0.40.40.9-0.6-0.1-0.50.6-0.30.90.40.30.7-0.70.70.90.90.9-0.6
Bone: cortical thickness0.91.54.9-1.9-1.3-1.81.9-1.62.2-0.3-0.61.60.3-0.40.10.10.10.2
Bone: cortical thickness1.41.65.6-0.9-1.1-1.00.6-0.81.2-2.4-2.30.81.4-1.1-1.0-0.9-0.90.9
Bone: cortical tissue density0.81.02.1-1.0-0.7-1.21.4-1.11.4-1.1-1.11.11.3-0.9-0.6-0.6-0.60.5
Condit. Reinf. active minus inactive responses1.41.62.81.71.41.5-1.61.7-1.30.91.1-1.5-1.11.20.90.90.9-0.9
Condit. Reinf. active-inactive response ratio0.20.20.80.70.10.5-0.70.9-0.50.10.2-0.5-0.0-0.1-0.3-0.3-0.30.2
Condit. Reinf. active responses2.53.14.01.92.01.8-1.71.8-1.51.41.5-1.8-1.92.01.81.71.7-1.7
Condit. Reinf. inactive responses1.82.13.61.11.61.2-1.00.9-1.11.11.0-1.2-1.81.91.81.81.8-1.7
Incentive salience index mean1.51.82.51.21.51.2-1.21.1-0.91.41.5-1.3-1.51.61.41.41.4-1.4
Condit. Reinf. lever presses1.72.34.30.11.50.4-0.2-0.3-0.22.12.0-0.6-1.71.92.12.12.1-1.9
Condit. Reinf. active minus inactive responses1.11.34.41.81.11.6-1.72.1-1.7-0.30.0-1.5-0.30.2-0.3-0.3-0.30.0
Condit. Reinf. active-inactive response ratio1.01.11.71.20.10.9-1.01.3-1.1-1.1-0.8-0.71.0-0.9-1.3-1.3-1.30.9
Condit. Reinf. active responses0.71.03.11.41.01.4-1.31.8-1.20.40.6-1.3-0.90.70.40.40.4-0.4
Condit. Reinf. inactive responses0.40.51.20.40.60.5-0.40.6-0.20.80.8-0.5-1.11.00.90.90.9-0.7
Condit. Reinf. lever presses1.41.94.82.21.42.0-2.22.1-2.0-0.50.0-2.0-0.40.60.10.00.0-0.3
Condit. Reinf. lever reinforcers received0.50.72.51.30.81.2-1.21.6-1.10.00.3-1.1-0.50.40.10.00.0-0.1
Conditioned reinforcement - actives0.30.30.6-0.30.2-0.10.40.20.50.70.8-0.2-0.70.60.70.70.7-0.6
Conditioned reinforcement - inactives1.31.52.6-1.0-1.2-1.21.0-0.30.8-1.2-1.30.71.4-1.6-1.5-1.5-1.51.3
Conditioned locomotion1.62.05.11.51.31.6-1.52.3-1.21.01.2-1.9-1.61.31.01.01.0-1.0
Patch foraging indifference point 0 sec2.43.88.9-2.7-2.4-2.72.8-2.43.0-1.0-1.22.51.4-1.2-0.7-0.6-0.61.1
Patch foraging indifference point AUC0.40.41.21.10.61.0-0.90.7-1.00.40.4-1.0-0.30.40.20.20.2-0.3
Delay disc. indifference point, 0s delay1.31.44.9-1.6-0.4-1.21.4-2.21.60.40.21.4-0.50.71.11.21.2-0.6
Delay disc. indifference point, 16s delay0.20.20.40.50.60.5-0.50.4-0.5-0.00.2-0.4-0.60.50.40.40.4-0.2
Delay disc. indifference point, 2s delay0.50.61.9-0.6-0.2-0.40.6-1.10.81.41.10.6-0.50.40.60.60.6-0.8
Delay disc. indifference point, 24s delay0.20.21.2-0.4-0.4-0.50.5-1.10.5-0.2-0.20.70.2-0.2-0.1-0.1-0.10.3
Delay disc. indifference point, 4s delay0.90.92.10.30.70.5-0.2-0.0-0.31.51.4-0.2-1.31.21.21.21.2-1.1
Delay disc. indifference point, 8s delay0.40.41.4-0.0-0.1-0.20.2-0.60.1-1.2-0.90.50.8-0.7-0.7-0.7-0.70.7
Indifference point function ln k0.10.20.4-0.7-0.5-0.60.5-0.10.6-0.4-0.40.50.3-0.4-0.2-0.2-0.20.3
Indifference point function log k0.10.20.4-0.7-0.5-0.60.5-0.10.6-0.4-0.40.50.3-0.4-0.2-0.2-0.20.3
Patch foraging total patch changes 0 sec2.33.78.4-2.6-2.4-2.62.6-2.22.9-1.0-1.32.51.4-1.3-0.8-0.8-0.71.2
Patch foraging total patch changes 12 sec2.12.74.8-1.3-1.9-1.61.3-1.51.5-2.1-2.21.61.8-1.6-1.4-1.4-1.41.5
Patch foraging total patch changes 18 sec0.00.00.1-0.0-0.2-0.20.3-0.20.3-0.2-0.20.20.2-0.1-0.1-0.1-0.10.2
Patch foraging total patch changes 24 sec0.30.31.3-0.9-0.6-0.90.9-1.10.80.1-0.10.70.2-0.20.00.00.00.1
Patch foraging total patch changes 6 sec1.32.03.6-1.8-1.8-1.91.8-1.51.9-1.1-1.31.71.0-1.1-0.7-0.7-0.70.9
Patch foraging time to switch 0 sec0.20.41.3-0.80.1-0.60.7-1.20.40.80.50.8-0.40.20.50.50.5-0.4
Patch foraging water rate 0 sec1.01.53.9-0.6-1.3-0.90.6-0.30.9-2.0-1.80.71.7-1.4-1.3-1.3-1.31.3
Patch foraging water rate 12 sec1.01.52.4-0.8-1.5-1.10.9-0.41.0-0.9-1.00.81.5-1.6-1.5-1.5-1.51.5
Patch foraging water rate 18 sec1.72.24.70.6-0.80.2-0.80.9-0.6-2.2-1.9-0.31.9-1.8-2.0-2.0-2.01.7
Patch foraging water rate 24 sec3.95.513.0-0.6-1.7-1.10.4-0.30.7-3.6-3.41.03.2-2.9-3.0-3.0-3.02.5
Patch foraging water rate 6 sec0.71.12.91.1-0.10.8-1.11.7-1.2-1.0-0.7-1.10.9-0.8-1.1-1.1-1.21.0
Seeking ratio, delayed vs. immediate footshock1.31.52.10.81.41.1-0.81.2-0.81.21.4-1.1-1.31.41.31.31.3-1.4
Distance traveled before self-admin0.70.71.00.90.61.0-1.00.9-0.70.91.0-0.8-0.90.90.70.70.7-0.7
Distance traveled after self-admin0.10.20.40.30.40.4-0.30.30.0-0.2-0.0-0.3-0.40.50.50.50.5-0.6
Extensor digitorum longus weight4.617.924.4-4.4-4.5-4.74.3-4.64.1-4.3-4.54.74.9-4.3-3.5-3.4-3.43.4
Bone: elastic displacement0.00.00.1-0.1-0.1-0.00.30.20.20.30.3-0.1-0.20.20.20.20.2-0.1
Bone: elastic work0.50.61.8-1.2-0.8-1.01.3-1.11.30.50.41.10.20.00.30.30.3-0.0
Bone: endosteal estimation0.71.55.5-1.5-1.0-1.31.7-1.11.12.31.91.4-0.7-0.00.40.40.4-0.0
Bone: endosteal perimeter0.71.44.20.20.60.40.00.50.12.01.9-0.0-1.81.41.41.41.4-1.2
Epididymis fat weight0.00.10.40.5-0.20.5-0.60.4-0.50.10.1-0.3-0.1-0.1-0.2-0.2-0.30.3
Delta time in closed arm before/after self-admin3.63.57.7-0.3-1.6-0.70.30.00.3-2.8-2.70.82.6-2.3-2.4-2.4-2.42.0
Delta time in open arm before/after self-admin0.80.73.2-1.2-1.1-1.11.0-1.81.00.50.41.10.3-0.3-0.1-0.0-0.00.5
Diff in mean of infusions in LGA sessions1.31.43.51.61.31.6-1.61.9-1.70.30.5-1.5-0.90.80.50.50.4-0.6
Delay discount exponential model param0.10.10.40.1-0.3-0.0-0.20.7-0.1-0.4-0.5-0.40.3-0.3-0.4-0.4-0.40.3
Extinction: sum of active levers before priming1.91.85.22.30.82.0-2.31.9-2.2-0.30.0-1.9-0.10.1-0.4-0.5-0.50.2
Active lever presses in extinction session 60.90.91.61.10.81.2-1.20.8-1.00.50.5-1.0-1.21.10.90.80.8-0.5
Bone: final force1.72.87.5-2.7-1.6-2.32.6-2.62.51.00.52.2-0.1-0.30.40.40.40.1
Bone: final moment1.72.77.2-2.7-1.6-2.32.5-2.52.51.00.52.2-0.1-0.20.40.40.40.1
Food consumed during 24 hour testing period0.40.51.1-0.9-1.1-0.80.7-0.80.8-0.7-0.81.00.4-0.5-0.3-0.3-0.30.5
Glucose1.42.13.2-1.7-1.7-1.81.6-1.71.5-1.6-1.71.81.6-1.2-0.8-0.8-0.80.9
Heart weight0.10.10.30.2-0.2-0.10.20.2-0.20.30.10.30.4-0.5-0.5-0.5-0.50.4
Delay discount hyperbolic model param0.20.20.70.3-0.10.2-0.40.9-0.3-0.5-0.5-0.50.3-0.3-0.3-0.4-0.40.3
Intermittent access intake day 1-15 change0.20.21.60.40.20.4-0.51.2-0.3-0.00.1-0.5-0.2-0.0-0.1-0.1-0.10.1
Intermittent access intake escalation0.80.81.70.5-0.40.3-0.61.3-0.5-1.1-0.9-0.50.9-0.9-1.1-1.2-1.21.0
Intermittent access intake escalation 20.70.72.81.00.10.8-1.01.7-1.0-0.8-0.7-0.70.5-0.5-0.8-0.8-0.80.6
Intermitt. access day 1 inactive lever presses1.01.13.00.5-0.40.2-0.51.1-0.9-1.7-1.6-0.31.1-1.0-1.2-1.2-1.21.0
Intermitt. access day 15 inactive lever presses0.80.82.51.20.81.0-1.21.6-1.0-1.2-0.8-1.30.5-0.2-0.5-0.5-0.50.1
Intermitt. access escalation Index1.00.91.8-0.40.7-0.00.30.10.21.01.00.0-1.31.21.31.31.3-1.2
Intermittent access day 1 total infusions0.20.30.9-0.8-0.5-0.70.8-0.90.7-0.4-0.30.30.4-0.10.00.10.10.1
Intermittent access day 15 total infusions0.30.30.8-0.4-0.6-0.50.4-0.00.6-0.9-0.80.00.8-0.6-0.5-0.5-0.50.5
Intermittent access terminal intake (last 3 days)0.20.20.7-0.8-0.2-0.60.7-0.30.80.10.10.1-0.10.10.30.30.3-0.2
Intermittent access total infusions0.30.30.8-0.8-0.7-0.80.8-0.60.9-0.6-0.50.40.6-0.5-0.3-0.3-0.30.4
Intermittent access day 1 locomotion0.00.00.10.0-0.1-0.0-0.0-0.2-0.2-0.1-0.0-0.40.2-0.2-0.2-0.2-0.20.1
Intermittent access day 15 total locomotion0.30.31.50.50.70.5-0.61.2-0.8-0.10.0-1.2-0.00.1-0.0-0.0-0.0-0.2
Intermittent access total locomotion0.20.20.70.40.70.5-0.40.4-0.50.40.5-0.9-0.40.40.30.30.3-0.4
Intermittent access standard deviation0.10.20.90.3-0.10.3-0.40.9-0.40.00.0-0.6-0.0-0.3-0.3-0.4-0.40.3
Left kidney weight0.51.44.6-0.90.5-0.50.9-0.90.12.21.90.4-1.31.11.41.41.4-1.3
Right kidney weight0.41.23.00.51.20.7-0.50.8-0.91.71.7-0.9-1.31.11.11.11.1-1.1
Cocaine induced anxiety2.02.33.61.11.81.3-1.10.8-0.91.71.9-1.2-1.71.81.71.71.7-1.7
Post-drug Anxiety1.92.14.10.11.20.4-0.1-0.20.02.01.9-0.3-1.81.81.92.02.0-1.8
Baseline Anxiety0.10.10.3-0.0-0.2-0.10.0-0.0-0.1-0.4-0.50.00.3-0.4-0.4-0.4-0.40.4
Tail length2.98.821.74.13.84.1-4.44.0-4.70.51.3-3.9-1.61.81.00.90.9-1.5
Length with tail1.34.68.82.52.92.7-2.72.3-3.01.31.8-2.6-1.61.81.41.31.3-1.7
Length without tail0.30.72.5-0.70.0-0.50.8-0.80.71.61.40.2-0.70.60.80.80.8-0.7
Times rat made contact with spout1.21.42.1-0.9-1.4-1.10.9-1.01.1-1.5-1.41.31.4-1.3-1.2-1.1-1.11.1
Lifetime Intake0.60.72.1-1.4-0.9-1.31.4-1.01.4-0.1-0.10.90.4-0.4-0.1-0.0-0.00.2
Liver weight, left1.32.13.9-1.4-2.0-1.71.4-1.21.4-1.0-1.31.71.2-1.6-1.4-1.3-1.31.4
Liver weight, right0.40.72.1-1.5-0.8-1.41.4-1.20.80.5-0.11.00.1-0.7-0.4-0.4-0.40.4
Locomotor activity3.35.210.61.93.32.4-2.41.9-2.61.52.0-2.5-2.32.32.02.02.0-2.4
Locomotor testing distance1.22.04.31.22.11.4-1.51.3-1.50.81.2-1.5-1.41.51.31.31.3-1.6
Locomotor testing rearing0.10.20.70.00.30.1-0.40.1-0.4-0.8-0.7-0.00.3-0.4-0.4-0.4-0.40.1
Locomotion in novel chamber0.20.30.8-0.6-0.9-0.60.7-0.40.6-0.2-0.40.90.4-0.4-0.3-0.3-0.30.2
Locomotion in novel chamber post-restriction2.12.54.82.11.52.1-2.22.1-2.10.60.8-2.0-1.51.40.90.90.9-1.0
Fecal boli incidents, locomotor time 11.21.32.5-0.4-1.3-0.70.6-0.70.4-1.5-1.60.51.5-1.4-1.4-1.4-1.41.3
Change in fecal boli incidents, locomotor task1.61.53.20.31.40.6-0.40.3-0.21.71.8-0.6-1.31.51.61.61.6-1.5
Time >=10cm from walls, locomotor time 10.60.61.4-1.1-0.6-0.91.1-1.11.20.60.40.5-0.40.40.70.70.7-0.3
Bouts of movement, locomotor time 10.30.30.90.70.70.8-0.70.8-0.9-0.2-0.0-1.0-0.40.30.10.10.1-0.0
Total resting periods, locomotor time 10.80.82.01.11.31.2-1.11.1-1.20.30.5-1.4-0.80.70.50.50.4-0.5
Rest time, locomotor task time 10.60.61.30.61.10.7-0.60.5-0.61.01.0-1.0-0.70.80.70.70.7-0.8
Distance moved, locomotor task time 10.60.61.5-1.1-0.6-1.01.1-1.01.20.30.11.2-0.30.30.70.70.7-0.4
Vertical activity count, locomotor time 11.11.12.2-1.2-1.1-1.21.0-0.71.2-1.3-1.31.51.0-1.0-0.8-0.8-0.80.9
Time >=10cm from walls, locomotor time 21.31.43.5-1.0-1.9-1.11.1-1.00.9-1.2-1.41.01.1-1.2-1.0-1.0-1.01.3
Bouts of movement, locomotor time 20.60.71.60.20.80.4-0.30.1-0.30.30.4-0.5-1.31.21.21.31.3-0.8
Total resting periods, locomotor time 20.80.81.90.10.90.4-0.20.0-0.20.50.6-0.4-1.31.31.41.41.4-1.0
Rest time, locomotor task time 20.60.72.1-0.00.80.10.0-0.2-0.11.51.4-0.2-0.80.91.01.01.0-1.0
Distance moved, locomotor task time 20.70.82.80.0-1.0-0.2-0.10.20.0-1.7-1.50.20.9-0.9-1.0-1.0-1.01.2
Vertical activity count, locomotor time 22.62.87.2-0.9-1.8-1.10.7-0.70.8-2.7-2.61.41.9-1.8-1.7-1.7-1.72.0
Light reinforcement 12.64.88.42.32.52.5-2.52.9-2.51.82.2-2.4-2.12.01.61.51.5-1.8
Light reinforcement 20.60.82.01.00.91.1-1.21.4-0.9-0.10.1-1.4-0.70.80.60.60.6-0.6
Bone: marrow area0.71.45.6-1.4-0.9-1.31.6-1.11.02.41.91.3-0.7-0.00.30.40.4-0.0
Bone: maximum diameter1.32.46.40.11.20.40.00.5-0.12.52.5-0.2-2.01.81.91.91.9-1.8
Bone: maximum force1.83.18.1-2.8-1.9-2.52.7-2.62.70.80.32.50.1-0.50.10.20.20.3
Bone: maximum moment1.83.18.0-2.8-1.8-2.52.7-2.52.70.90.42.50.1-0.50.20.20.20.3
Mean time between licks in bursts0.40.62.11.40.41.1-1.21.4-1.1-0.10.1-0.9-0.20.2-0.1-0.2-0.20.1
Mean num. licks in bursts0.70.81.50.81.21.0-0.80.9-0.80.91.2-0.7-0.91.00.80.80.8-0.9
Cd content in liver0.40.51.2-0.2-1.1-0.60.6-0.90.7-0.8-0.90.80.8-0.4-0.3-0.3-0.30.7
Co content in liver0.70.92.11.51.11.3-1.41.2-1.2-1.0-0.6-1.30.10.2-0.2-0.2-0.2-0.2
Cu content in liver0.91.13.3-1.5-0.7-1.41.5-1.11.8-0.7-0.71.40.10.30.80.80.8-0.6
Fe content in liver0.70.81.4-0.6-1.1-0.80.6-0.80.8-1.1-1.20.80.9-1.0-0.9-0.9-0.90.9
K content in liver1.21.13.00.30.80.6-0.40.4-0.51.71.7-0.5-1.51.21.21.21.2-1.2
Mg content in liver1.41.44.60.20.70.4-0.1-0.1-0.32.11.9-0.3-1.61.41.41.41.4-1.3
Mn content in liver3.43.910.0-0.21.00.30.2-0.20.03.22.8-0.2-2.82.42.62.62.6-2.2
Na content in liver0.30.30.8-0.5-0.0-0.30.4-0.60.70.90.70.5-0.70.50.60.60.6-0.5
Rb content in liver0.70.82.0-1.3-0.4-1.11.3-0.91.40.80.51.1-0.60.50.80.80.9-0.7
Se content in liver0.00.00.10.10.20.2-0.0-0.1-0.1-0.4-0.1-0.10.10.30.30.30.3-0.2
Sr content in liver0.70.61.20.5-0.00.4-0.61.0-0.8-0.9-0.7-0.50.5-0.8-1.1-1.1-1.10.9
Zn content in liver1.71.94.02.00.81.7-2.01.8-1.8-1.4-1.1-1.60.5-0.6-1.1-1.1-1.20.6
Bone: minimum diameter0.50.92.6-0.9-0.2-0.81.2-0.81.21.61.30.8-0.80.60.90.90.9-0.7
Time in familiar zone, hab. session 12.72.56.52.41.52.4-2.62.3-2.3-0.00.4-2.1-0.91.00.40.40.4-0.5
Time in novel zone, hab. session 12.12.05.3-2.3-1.1-2.12.3-2.22.10.70.21.90.1-0.20.40.50.5-0.2
Total zone transitions, hab. session 10.91.22.90.51.10.7-0.50.1-0.40.40.6-0.6-1.21.71.71.71.7-1.6
Total locomotion distance, hab. session 12.94.27.71.02.21.3-1.10.7-1.01.81.9-1.4-2.42.82.82.82.8-2.7
Locomotion velocity, hab. session 12.43.56.11.22.21.5-1.31.0-1.21.41.5-1.5-2.12.52.42.42.4-2.3
Time in familiar zone, hab. session 22.62.77.52.61.72.4-2.52.7-2.3-0.30.3-2.2-0.40.60.0-0.0-0.0-0.2
Time in novel zone, hab. session 23.03.07.8-2.8-1.7-2.62.7-2.82.60.1-0.52.40.5-0.50.10.20.20.1
Total zone transitions, hab. session 20.81.12.2-1.20.2-0.91.0-1.21.10.0-0.00.8-0.61.11.41.51.5-1.2
Total locomotion distance, hab. session 20.81.12.60.31.40.6-0.40.1-0.30.50.6-0.6-1.01.51.51.51.5-1.6
Locomotion velocity, hab. session 21.21.63.60.31.50.6-0.40.0-0.30.91.0-0.6-1.31.81.91.91.9-1.9
Novel to familiar place preference ratio1.71.74.7-2.2-1.0-1.91.7-2.12.1-0.1-0.41.8-0.10.10.60.70.7-0.4
Novelty place preference1.21.23.1-1.7-0.8-1.51.4-1.71.8-0.1-0.41.5-0.20.20.70.70.7-0.5
Time in novel zone, NPP test1.51.54.0-2.0-1.0-1.81.6-1.92.0-0.3-0.71.70.00.00.50.50.6-0.3
Total zone transitions, NPP test0.30.41.4-0.8-0.2-0.70.7-1.20.8-0.1-0.20.7-0.00.40.70.70.7-0.4
Total locomotion distance, NPP test0.50.61.5-0.40.6-0.20.4-0.70.50.60.60.2-0.61.01.21.21.2-1.1
Locomotion velocity, NPP test0.50.71.7-0.10.90.10.1-0.40.10.90.9-0.1-0.81.21.31.31.3-1.2
Intraocular pressure0.60.92.71.20.20.9-1.10.9-0.8-1.6-1.1-0.51.0-0.5-0.9-0.9-0.90.7
Delta distance traveled before/after self-admin0.10.10.4-0.30.2-0.20.3-0.30.3-0.6-0.50.20.30.00.10.10.1-0.5
Delta ambulatory time before/after self-admin0.10.20.5-0.40.3-0.30.4-0.50.4-0.1-0.10.2-0.20.40.50.50.5-0.7
Parametrial fat weight0.00.10.10.3-0.30.3-0.30.4-0.3-0.3-0.4-0.10.1-0.2-0.3-0.3-0.30.3
Pavlov. Cond. lever latency0.70.81.8-0.1-1.0-0.2-0.10.1-0.4-1.0-0.90.20.9-1.2-1.3-1.3-1.31.3
Pavlov. Cond. magazine entry latency1.01.33.21.81.41.6-1.51.6-1.30.91.0-1.5-0.70.70.40.40.4-0.6
Pavlov. Cond. change in total contacts0.10.10.5-0.2-0.3-0.40.4-0.30.70.1-0.00.50.1-0.10.00.00.0-0.0
Pavlov. Cond. index score0.70.91.50.81.20.8-0.60.5-0.31.11.1-0.7-0.91.21.11.11.1-1.2
Pavlov. Cond. latency score1.11.42.20.71.50.8-0.60.5-0.31.51.4-0.8-1.21.51.51.51.5-1.4
Pavlov. Cond. lever contacts0.91.12.4-0.11.00.00.2-0.50.51.21.1-0.0-0.91.41.51.61.6-1.5
Pavlov. Cond. magazine entry number0.50.71.5-1.1-0.9-0.90.8-0.80.7-1.2-1.20.90.6-0.6-0.4-0.4-0.40.6
Pavlov. Cond. intertrial magazine entries0.50.61.90.4-0.20.3-0.60.6-0.8-1.4-1.2-0.30.7-0.6-0.8-0.8-0.80.8
Pavlov. Cond. lever-magazine prob. diff.0.81.01.50.91.20.9-0.70.7-0.41.11.2-0.8-1.01.21.11.11.1-1.2
Pavlov. Cond. response bias0.60.71.51.21.01.1-1.00.9-0.70.91.0-0.9-0.60.80.60.60.6-0.7
Pavlov. Cond. lever latency1.01.42.8-1.6-1.4-1.61.6-1.21.6-0.2-0.61.70.8-1.0-0.7-0.7-0.70.9
Pavlov. Cond. magazine entry latency1.72.03.11.81.61.7-1.71.5-1.71.11.2-1.7-1.41.31.00.90.9-1.1
Pavlov. Cond. change in total contacts0.50.71.31.10.71.0-1.11.0-1.10.70.8-1.0-0.90.50.30.30.3-0.4
Pavlov. Cond. index score1.31.73.41.91.41.7-1.81.6-1.70.60.8-1.7-1.11.00.70.70.6-0.8
Pavlov. Cond. latency score1.51.93.21.81.51.7-1.71.5-1.70.91.1-1.7-1.31.30.90.90.9-1.0
Pavlov. Cond. lever contacts0.81.12.51.61.11.5-1.61.3-1.5-0.30.1-1.5-0.50.60.30.30.3-0.5
Pavlov. Cond. magazine entry number1.51.93.1-1.7-1.5-1.71.6-1.61.6-1.0-1.11.71.5-1.3-1.0-0.9-0.91.0
Pavlov. Cond. intertrial magazine entries0.81.02.2-1.0-0.7-1.00.7-0.90.7-1.2-1.10.81.5-1.3-1.1-1.1-1.10.9
Pavlov. Cond. lever-magazine prob. diff.1.41.83.51.91.41.7-1.71.6-1.70.70.9-1.7-1.21.20.80.80.8-1.0
Pavlov. Cond. response bias1.31.74.02.01.41.8-1.91.8-1.90.20.5-1.9-0.80.80.40.40.4-0.6
Time in closed arm before self-admin0.70.81.9-0.70.3-0.40.8-0.90.61.41.10.4-0.70.81.11.11.1-1.3
Time in closed arm after self-admin0.20.20.6-0.7-0.2-0.60.8-0.20.8-0.2-0.20.60.7-0.3-0.2-0.2-0.1-0.6
Time in open arm before self-admin0.30.41.80.5-0.10.4-0.51.3-0.2-0.6-0.5-0.4-0.4-0.2-0.4-0.5-0.51.0
Time in open arm after self-admin1.21.44.5-0.9-1.9-1.10.8-1.21.0-0.8-1.01.10.5-1.1-1.0-1.0-1.02.1
Bone: periosteal estimation1.22.46.2-1.9-0.9-1.72.2-1.61.92.52.01.8-1.10.51.11.11.1-0.6
Bone: periosteal perimeter0.81.33.1-0.60.2-0.40.8-0.30.91.81.50.4-1.61.31.51.51.5-1.3
Bone: post-yield work0.20.30.8-0.9-0.4-0.80.8-0.60.40.50.30.70.2-0.5-0.3-0.3-0.20.2
Progressive ratio test 1 active lever presses0.90.91.8-1.3-1.1-1.31.3-1.21.1-0.2-0.30.80.8-0.9-0.7-0.6-0.60.8
Progressive ratio test 1 breakpoint0.90.92.0-1.4-1.1-1.41.4-1.31.10.1-0.10.80.7-0.9-0.6-0.5-0.50.7
Progressive ratio test 1 inactive lever presses0.10.10.3-0.40.2-0.20.30.60.20.50.4-0.2-0.40.10.20.20.2-0.2
Progressive ratio test 2 active lever presses0.30.30.9-1.0-0.4-0.91.0-0.60.80.1-0.00.50.3-0.4-0.2-0.2-0.20.2
Progressive ratio test 2 breakpoint0.30.30.7-0.80.2-0.50.7-0.40.60.80.80.1-0.50.30.50.50.5-0.5
Progressive ratio test 2 inactive lever presses0.20.31.0-0.9-0.1-0.70.9-0.41.00.40.30.4-0.20.10.30.40.4-0.3
Incentive Sensitization - Responses0.10.10.40.20.50.3-0.20.6-0.30.10.2-0.3-0.20.20.20.20.2-0.3
Incentive Sensitization - Breakpoint0.20.20.50.20.70.3-0.20.7-0.30.40.5-0.4-0.50.50.50.50.5-0.6
Sum of active levers in priming session hrs 5-60.20.20.50.6-0.20.6-0.70.6-0.5-0.3-0.3-0.4-0.10.20.10.10.1-0.2
Progressive ratio0.91.11.5-1.2-1.2-1.21.1-0.90.9-1.0-1.11.01.2-1.1-0.9-0.9-0.90.9
Food seeking constrained by brief footshock1.01.23.01.71.21.6-1.71.2-1.3-0.20.0-1.5-0.70.90.60.50.5-0.6
Seeking ratio, punishment vs. effort1.51.83.71.91.61.9-1.91.5-1.60.50.7-1.6-1.21.20.80.80.8-0.8
Retroperitoneal fat weight1.65.48.7-2.8-2.7-2.92.7-2.72.1-1.6-1.92.82.6-2.3-1.8-1.7-1.71.8
Reaction time number correct1.31.93.2-0.9-1.8-1.10.8-0.81.1-1.4-1.41.21.6-1.6-1.6-1.6-1.61.7
Reaction time mean minus median1.52.05.31.42.31.5-1.51.2-1.81.41.7-1.3-0.91.20.90.90.9-1.3
Reaction time mean minus median AUC3.34.29.71.02.81.4-1.10.7-1.33.03.1-1.1-2.22.22.22.22.2-2.4
Reaction time num false alarms0.60.81.7-0.8-0.8-0.90.7-0.90.6-1.2-1.30.51.1-0.9-0.7-0.7-0.70.7
Reaction time num false alarms AUC0.91.22.9-0.8-1.0-0.90.6-0.90.5-1.7-1.70.51.5-1.2-1.1-1.1-1.11.1
Reaction time trials correct on left1.31.93.2-0.9-1.8-1.10.8-0.81.1-1.4-1.41.21.6-1.6-1.6-1.6-1.61.7
Reaction time trials on left1.21.73.0-0.9-1.7-1.10.8-0.91.1-1.3-1.31.21.5-1.5-1.5-1.5-1.51.6
Reaction time mean1.42.03.01.31.71.3-0.90.7-1.11.71.7-1.0-1.51.71.61.61.5-1.5
Reaction time mean AUC1.01.32.50.81.30.8-0.40.3-0.61.61.5-0.5-1.21.41.31.31.3-1.3
Median of all reaction times0.81.11.80.91.10.9-0.50.3-0.61.31.2-0.6-1.11.41.31.31.3-1.2
Reaction time omissions0.10.10.2-0.10.2-0.10.2-0.00.10.20.10.3-0.40.40.40.40.4-0.4
Reaction time false alarm rate0.10.10.4-0.4-0.0-0.40.3-0.60.1-0.6-0.6-0.00.4-0.1-0.00.00.0-0.1
Reaction time premature initiation rate1.01.33.71.61.11.5-1.71.8-1.9-0.7-0.3-1.50.1-0.0-0.4-0.4-0.40.0
Reaction time premature initiations0.91.32.01.10.10.9-1.31.4-1.3-1.4-1.0-0.91.0-0.9-1.3-1.3-1.31.0
Std. dev. reaction times1.11.63.31.01.81.1-0.90.6-1.11.71.8-0.8-1.21.31.21.21.2-1.4
Reaction time trials completed1.21.73.0-0.9-1.7-1.10.8-0.91.1-1.3-1.31.21.5-1.5-1.5-1.5-1.51.6
Reaction time trials AUC1.62.33.9-0.9-2.0-1.10.8-0.91.1-1.7-1.71.21.8-1.8-1.7-1.7-1.71.9
Run reversals in cocaine runway, females1.41.42.21.31.51.4-1.31.1-0.80.70.8-1.2-1.41.41.11.11.1-1.2
Run reversals in cocaine runway, males2.32.23.31.31.81.5-1.31.5-1.31.41.5-1.7-1.81.61.41.41.3-1.4
Latency to leave start box in cocaine runway1.11.22.9-0.80.5-0.40.7-1.00.51.71.70.3-1.01.11.41.41.4-1.3
Latency to leave start box in cocaine runway, F2.12.35.6-1.00.6-0.51.0-1.30.92.42.20.5-1.61.61.91.92.0-1.6
Latency to leave start box in cocaine runway, M0.60.62.30.1-0.1-0.0-0.20.1-0.4-1.5-1.20.01.3-0.8-0.9-0.9-0.90.6
Std. dev. time between licks in bursts0.91.12.40.30.80.5-0.50.8-0.41.00.9-0.9-1.51.41.41.41.4-1.3
Total sessions with >9 infusions1.21.33.3-1.3-0.2-0.91.2-0.41.41.81.60.7-1.40.91.21.21.2-0.9
Short access day 1 total inactive lever presses0.00.10.3-0.30.1-0.20.30.30.5-0.2-0.2-0.0-0.10.10.10.20.2-0.2
Short access day 10 total inactive lever presses0.60.62.40.1-0.1-0.1-0.10.8-0.6-1.5-1.5-0.10.8-0.8-0.9-0.9-0.90.6
Short access day 1 total infusions1.51.63.3-1.8-0.1-1.31.7-0.71.71.81.60.7-1.10.61.11.11.1-0.9
Short access day 10 total infusions0.50.51.5-1.2-0.8-1.11.2-0.91.2-0.2-0.20.70.4-0.4-0.2-0.2-0.20.3
Short access total infusions1.31.54.2-2.0-0.7-1.72.0-1.41.81.20.91.2-0.50.10.60.70.7-0.4
Short access day 1 locomotion0.40.41.0-0.20.70.00.10.10.21.01.0-0.4-0.90.60.70.70.7-0.8
Short access day 10 total locomotion1.01.14.41.40.81.3-1.32.1-1.6-0.3-0.1-1.6-0.30.2-0.1-0.2-0.2-0.1
Short access total locomotion0.30.31.00.20.50.3-0.20.5-0.51.01.0-0.8-0.80.50.50.50.5-0.5
One hour access (0.3 mA shock)0.30.41.1-0.8-0.7-0.80.9-0.81.0-0.5-0.40.70.6-0.4-0.2-0.2-0.20.3
Compulsive drug intake0.30.30.7-0.5-0.3-0.50.6-0.80.6-0.8-0.70.80.5-0.1-0.00.00.00.0
One hour access (shock baseline)0.30.40.8-0.2-0.9-0.40.20.20.4-0.6-0.6-0.00.7-0.8-0.8-0.8-0.80.9
Social response proportion1.11.22.00.81.41.0-0.80.7-0.91.41.4-1.1-1.41.11.01.01.0-1.1
Social responses7.69.814.33.13.83.5-3.23.1-3.42.93.3-3.7-3.33.12.52.52.5-2.7
Social time0.70.91.5-1.2-0.8-1.21.0-1.20.6-0.7-0.80.71.2-1.1-0.9-0.9-0.90.7
Soleus weight4.112.020.4-4.5-3.4-4.44.3-4.54.1-2.8-3.14.23.5-3.0-2.1-2.0-2.02.2
Bone: stiffness2.64.211.1-3.3-2.2-3.03.0-3.03.00.4-0.22.90.5-1.1-0.4-0.3-0.30.8
Tibialis anterior weight0.82.65.5-2.2-1.8-2.12.0-2.31.5-0.7-0.72.11.7-1.4-1.0-1.0-1.01.1
Time to tail flick, vehicle, before self-admin3.53.69.70.61.91.0-0.51.3-0.42.62.5-1.1-1.92.22.22.22.2-3.1
Time to tail flick, vehicle, after self-admin0.50.51.40.80.30.6-0.80.8-1.2-0.6-0.5-0.50.3-0.5-0.7-0.7-0.70.8
Time to tail flick, test, before self-admin2.12.14.20.61.70.9-0.60.6-0.72.12.0-1.1-1.81.61.71.71.7-1.6
Time to tail flick, test, after self-admin0.80.82.7-0.1-0.00.10.1-0.10.21.61.5-0.0-1.01.11.21.21.2-1.1
Delta time to tail flick, vehicle, before/after SA2.92.97.1-0.2-1.5-0.60.2-1.0-0.1-2.5-2.40.81.9-2.0-2.1-2.1-2.12.7
Delta time to tail flick, test, before/after SA0.40.30.60.5-0.80.3-0.50.4-0.3-0.8-0.60.00.8-0.5-0.6-0.7-0.70.5
Tibia length0.71.94.41.81.91.9-2.01.5-2.10.30.8-2.0-0.60.80.40.40.4-0.8
Ambulatory time before self-admin0.20.20.40.50.00.5-0.50.7-0.20.50.5-0.3-0.60.40.30.30.3-0.0
Ambulatory time after self-admin0.00.10.20.00.10.1-0.10.10.3-0.3-0.10.0-0.10.30.30.30.3-0.4
Bone: tissue strength2.92.86.5-2.4-2.2-2.32.5-2.12.40.70.32.50.6-1.0-0.5-0.5-0.51.0
Total heroin consumption1.61.93.01.71.21.7-1.71.5-1.60.80.9-1.5-1.41.51.21.21.1-1.1
Bone: trabecular number1.52.44.60.31.50.8-0.50.1-0.51.71.8-1.1-1.92.02.12.12.1-2.2
Bone: trabecular spacing2.83.77.40.4-1.4-0.2-0.20.5-0.1-2.7-2.60.42.4-2.3-2.6-2.6-2.62.5
Bone: trabecular thickness4.55.410.5-1.31.1-0.61.1-1.31.13.23.00.2-2.72.73.23.23.2-2.8
Bone: trabecular tissue density4.86.78.9-2.8-2.8-3.02.7-2.62.8-2.4-2.63.02.6-2.7-2.2-2.1-2.12.2
Water consumed over 24 hours0.70.92.7-1.7-0.6-1.21.3-1.31.4-0.2-0.41.2-0.30.30.70.70.7-0.5
Number of responses in last shaping day0.70.72.40.81.20.9-0.81.6-0.70.50.7-1.2-0.60.60.50.50.5-0.7