Hub : Genes

Gls2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Gls2 0.03 0.02 8.1e-05 0.02 0.02 0.02 0.02 1.9e-04 3.2e-04 1.3e-04 4.8e-04
2 pVTA alternative TSS NM_001270787.1 0.07 0.05 3.2e-04 0.02 0.02 0.03 0.03 7.4e-03 5.2e-03 1.1e-03 2.1e-03
3 pVTA alternative TSS NM_001270787.1 0.07 0.05 1.7e-04 0.02 0.03 0.03 0.03 4.4e-03 4.1e-03 2.5e-03 1.5e-03
4 OFC intron excision ratio chr7_1207336_1207703 0.14 0.1 7.6e-03 0.09 0.05 0.06 0.06 4.2e-03 2.2e-02 1.7e-02 1.7e-02
5 pVTA intron excision ratio chr7_1207336_1207703 0.03 0.03 4.5e-03 0.03 0.02 0.02 0.02 2.1e-03 8.5e-03 5.9e-03 8.0e-03
6 pVTA isoform ratio NM_001270787.1 0.05 0.04 2.7e-03 0.02 0.01 0.02 0.02 7.0e-03 3.1e-02 7.6e-03 1.1e-02
7 Brain intron excision ratio chr7_1207336_1207703 0.04 0.03 7.4e-04 0.03 0.02 0.02 0.02 4.9e-04 5.4e-03 5.2e-03 3.6e-03
8 PL alternative TSS NM_001270787.1 0.03 0.02 5.9e-03 0.02 0.01 0.01 0.02 2.8e-03 2.5e-02 1.4e-02 6.2e-03
9 PL alternative TSS NM_001270787.1 0.03 0.02 4.9e-03 0.02 0.01 0.02 0.02 2.7e-03 1.4e-02 5.1e-03 3.8e-03
10 Liver mRNA stability Gls2 0.06 0.04 3.0e-06 0.04 0.04 0.03 0.03 6.7e-05 5.1e-05 1.4e-04 3.3e-04
11 pVTA intron excision ratio chr7_1202296_1207237 0.04 0.03 6.2e-03 0.01 0.01 0 0.01 1.0e-01 3.2e-02 1.3e-01 8.3e-02
12 pVTA isoform ratio NM_001270786.1 0.16 0.11 1.4e-08 0.08 0.08 0.07 0.08 9.9e-07 2.6e-07 3.5e-06 8.7e-07
13 Brain isoform ratio NM_001270786.1 0.07 0.05 4.0e-05 0.04 0.04 0.04 0.04 2.1e-04 1.0e-04 1.8e-04 1.3e-04
14 Brain alternative TSS XM_006240730.4 0.04 0.04 9.6e-03 0.01 0.01 0.01 0.01 1.9e-02 3.8e-02 4.2e-02 2.1e-02
15 Brain mRNA stability Gls2 0.04 0.03 6.6e-03 0.02 0.02 0.01 0.02 1.2e-02 3.9e-03 1.3e-02 1.0e-02
16 BLA gene expression Gls2 0.15 0.1 5.2e-07 0.06 0.13 0.11 0.12 3.7e-04 2.8e-07 1.4e-06 5.7e-07
17 OFC gene expression Gls2 0.44 0.2 2.2e-06 0.17 0.26 0.26 0.26 9.6e-05 8.1e-07 5.4e-07 5.5e-07
18 IC gene expression Gls2 0.15 0.1 2.8e-05 0.07 0.08 0.09 0.08 7.3e-04 2.1e-04 1.0e-04 2.8e-04
19 PL gene expression Gls2 0.17 0.1 1.0e-15 0.1 0.15 0.15 0.15 4.6e-11 7.3e-16 5.4e-16 1.2e-15
20 Brain gene expression Gls2 0.04 0.03 5.0e-03 0.01 0.02 0.02 0.01 4.6e-02 9.3e-03 9.8e-03 1.7e-02
21 RMTg intron excision ratio chr7_1207824_1208464 0.17 0.11 1.6e-03 -0 0.01 0.03 0 3.9e-01 2.1e-01 6.7e-02 3.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.81.44.40.40.40.50.50.51.0-0.70.70.7-1.0-0.9-0.9-0.8-1.0-1.61.81.82.11.92.1-0.9
Area under the delay curve0.00.00.1-0.00.10.10.4-0.40.2-0.00.00.0-0.1-0.1-0.1-0.10.0-0.10.1-0.10.10.10.1-0.0
BMI with tail6.723.031.7-5.65.65.6-5.3-5.45.3-5.45.45.45.0-5.3-5.3-5.3-5.1-4.5-3.7-3.6-2.6-3.3-2.92.8
BMI without tail1.75.37.8-2.82.72.7-2.4-2.82.4-2.52.52.52.4-2.5-2.5-2.5-2.1-2.0-1.9-1.9-1.6-1.7-1.51.8
Body weight1.04.48.6-2.62.32.2-2.1-2.92.0-2.02.02.02.3-2.0-2.0-2.0-1.5-1.4-2.0-2.3-2.0-2.0-1.82.2
Weight adjusted by age0.10.10.60.1-0.3-0.30.2-0.1-0.30.2-0.2-0.2-0.00.30.30.30.30.4-0.1-0.2-0.1-0.2-0.20.8
Bone surface2.03.612.41.40.00.11.31.60.8-0.30.30.3-2.0-0.7-0.8-0.7-0.9-1.93.03.23.53.23.4-2.4
Bone volume2.03.511.91.10.30.41.21.31.2-0.60.60.6-1.8-1.0-1.1-0.9-1.1-2.22.93.03.43.13.3-2.1
Breakpoint value in progressive ratio session0.70.91.21.0-1.1-1.10.61.0-1.11.1-1.1-1.1-0.91.11.11.11.00.90.60.60.40.50.4-1.0
Number of licking bursts2.13.45.2-2.31.81.8-2.3-2.31.6-1.71.71.72.2-1.6-1.5-1.6-1.3-1.0-2.1-2.2-1.5-2.2-1.91.7
Context. condit. distance diff. score0.20.30.6-0.60.50.5-0.8-0.50.5-0.60.60.60.6-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.2-0.6-0.40.5
Locomotion velocity, session 10.50.51.40.20.30.40.40.20.6-0.40.40.4-0.5-0.6-0.6-0.6-0.7-1.01.01.01.11.11.2-0.3
Locomotion distance, session 10.81.13.41.0-0.3-0.20.91.10.10.1-0.1-0.1-1.2-0.1-0.1-0.1-0.2-0.71.61.81.81.81.8-1.2
Locomotion velocity, session 22.02.35.91.8-1.2-1.11.91.9-0.60.8-0.8-0.8-2.00.60.60.60.5-0.22.22.42.32.42.3-1.1
Locomotion distance, session 23.14.38.12.4-2.1-2.02.82.2-1.51.7-1.7-1.7-2.71.51.41.51.40.62.82.72.32.82.7-1.2
Locomotion velocity, session 33.94.56.22.3-2.4-2.52.12.3-2.42.5-2.5-2.5-2.12.42.42.42.12.11.51.31.01.21.1-1.9
Locomotion distance, session 30.10.10.20.2-0.4-0.40.20.2-0.50.4-0.4-0.4-0.20.40.40.40.40.40.00.1-0.20.1-0.1-0.1
Stereotopy head waving bouts, day 34.85.77.82.8-2.6-2.62.72.7-2.42.5-2.5-2.5-2.62.42.42.42.41.92.22.21.82.11.8-2.1
Stereotopy head waving duration, day 33.13.76.12.4-2.0-2.02.12.5-1.81.9-1.9-1.9-2.01.91.91.91.61.51.71.91.71.71.4-2.1
Locomotion velocity, session 70.10.20.60.4-0.2-0.20.20.6-0.00.1-0.1-0.1-0.40.00.00.00.1-0.20.50.70.80.60.6-0.7
Locomotion distance, session 70.20.30.9-0.50.20.2-0.6-0.50.0-0.20.20.20.7-0.0-0.0-0.1-0.10.3-0.9-0.9-0.8-1.0-1.00.2
Stereotopy head waving bouts, day 71.11.32.91.3-0.8-0.81.11.3-0.60.8-0.8-0.8-1.50.70.60.70.40.11.61.51.71.51.6-1.4
Stereotopy head waving duration, day 71.11.33.31.3-0.9-0.81.31.3-0.50.7-0.7-0.7-1.60.50.50.60.5-0.11.81.71.71.71.8-0.9
Locomotion velocity, session 81.72.14.81.6-1.2-1.21.71.5-0.80.9-0.9-0.9-2.00.80.70.80.60.02.22.12.12.12.2-1.0
Locomotion distance, session 80.40.61.00.8-1.0-0.90.90.7-0.60.7-0.7-0.7-1.00.60.60.60.60.31.00.90.70.90.90.0
Degree of sensitization distance0.60.60.8-0.80.90.9-0.9-0.70.9-0.90.90.90.8-0.9-0.9-0.9-0.9-0.8-0.5-0.6-0.2-0.6-0.40.3
Degree of sensitization stereotypy0.20.20.7-0.00.30.4-0.10.00.5-0.40.40.4-0.3-0.5-0.5-0.4-0.7-0.70.60.60.80.60.7-0.5
Conditioned locomotion1.31.53.8-1.30.80.7-1.2-1.40.4-0.70.70.71.5-0.5-0.5-0.5-0.60.1-1.8-1.8-2.0-1.8-1.82.0
Cocaine response after cond. corrected2.42.95.3-2.01.51.5-2.3-1.91.3-1.51.51.52.1-1.2-1.2-1.3-1.6-0.6-2.2-2.1-1.7-2.2-2.11.3
Cocaine response after cond. not corrected2.63.15.3-2.11.61.5-2.3-2.01.2-1.51.51.52.2-1.3-1.2-1.3-1.5-0.5-2.3-2.2-2.1-2.2-2.21.5
Cocaine response before conditioning0.50.61.00.8-0.6-0.61.00.8-0.80.8-0.8-0.8-0.90.60.60.70.90.40.80.90.30.90.7-0.7
Saline control response0.60.72.8-1.00.70.7-0.6-1.30.4-0.60.60.61.0-0.5-0.5-0.5-0.3-0.2-1.0-1.1-1.4-0.9-1.01.7
Bone: connectivity density0.50.82.30.30.30.30.30.40.6-0.50.50.5-0.7-0.6-0.7-0.6-1.0-1.21.31.41.51.41.5-0.7
Bone: cortical apparent density1.01.42.3-1.11.21.2-1.0-0.91.5-1.51.51.51.1-1.4-1.4-1.4-1.5-1.3-0.7-0.5-0.4-0.5-0.51.2
Bone: cortical area1.01.53.9-0.41.31.3-0.7-0.11.6-1.41.41.40.1-1.6-1.6-1.5-1.5-2.00.70.91.30.81.1-0.4
Bone: cortical porosity0.10.10.40.10.10.1-0.20.30.2-0.30.30.3-0.3-0.3-0.3-0.3-0.3-0.50.50.60.30.60.70.2
Bone: cortical porosity0.40.41.1-0.00.40.4-0.30.20.7-0.60.60.6-0.2-0.7-0.7-0.7-0.8-1.10.70.80.60.80.90.1
Bone: cortical thickness1.32.24.3-1.11.71.7-1.1-0.81.9-1.91.91.90.9-1.9-1.9-1.9-2.0-2.1-0.20.10.10.10.21.1
Bone: cortical thickness0.80.92.3-1.10.80.8-1.1-1.00.6-0.90.90.91.1-0.8-0.7-0.8-0.8-0.4-1.1-1.0-1.1-1.0-1.01.5
Bone: cortical tissue density0.71.01.7-0.91.01.0-0.8-0.81.3-1.31.31.30.9-1.2-1.2-1.2-1.3-1.1-0.6-0.4-0.3-0.4-0.41.1
Condit. Reinf. active minus inactive responses1.61.82.71.5-1.6-1.60.91.7-1.41.4-1.4-1.4-1.41.41.41.40.91.11.11.21.31.00.9-1.6
Condit. Reinf. active-inactive response ratio0.20.21.80.2-0.4-0.4-0.40.4-0.50.5-0.5-0.5-0.10.50.60.5-0.00.6-0.20.00.2-0.2-0.3-1.4
Condit. Reinf. active responses2.63.25.12.2-2.0-2.01.82.3-1.61.7-1.7-1.7-2.11.61.61.61.41.02.02.02.11.91.8-1.3
Condit. Reinf. inactive responses1.92.34.21.8-1.6-1.52.11.7-1.11.2-1.2-1.2-1.91.11.01.11.60.52.01.81.71.81.90.0
Incentive salience index mean1.31.63.01.5-1.4-1.31.11.6-1.01.0-1.0-1.0-1.61.01.01.00.70.51.51.61.71.51.5-1.3
Condit. Reinf. lever presses0.91.23.81.1-0.7-0.71.11.0-0.20.3-0.3-0.3-1.50.20.10.20.1-0.51.81.82.01.91.9-0.6
Condit. Reinf. active minus inactive responses1.82.34.41.4-1.7-1.71.21.4-2.01.9-1.9-1.9-1.02.02.02.01.92.10.30.2-0.20.0-0.1-0.9
Condit. Reinf. active-inactive response ratio0.91.13.20.3-0.8-0.90.10.2-1.31.2-1.2-1.20.11.31.41.31.21.8-0.9-0.9-1.1-1.1-1.2-0.3
Condit. Reinf. active responses1.31.82.61.5-1.4-1.41.21.5-1.51.6-1.6-1.6-1.21.61.61.61.51.40.80.70.40.60.5-1.0
Condit. Reinf. inactive responses0.30.40.90.9-0.6-0.50.70.9-0.50.5-0.5-0.5-0.90.40.40.50.50.10.90.90.60.80.9-0.3
Condit. Reinf. lever presses2.02.85.31.7-1.8-1.81.61.6-2.12.1-2.1-2.1-1.32.12.12.12.32.10.60.50.10.30.2-0.6
Condit. Reinf. lever reinforcers received0.91.32.21.2-1.2-1.30.91.2-1.41.4-1.4-1.4-0.91.51.51.51.51.50.40.3-0.00.20.1-0.6
Conditioned reinforcement - actives0.10.10.7-0.20.10.2-0.80.30.8-0.20.20.20.2-0.2-0.2-0.2-0.4-0.2-0.20.1-0.4-0.2-0.10.1
Conditioned reinforcement - inactives0.40.61.3-0.80.70.7-1.0-0.50.9-0.70.70.71.1-0.6-0.6-0.6-0.6-0.3-1.1-0.8-1.1-0.9-1.00.9
Conditioned locomotion1.52.06.31.8-1.4-1.41.22.5-0.81.3-1.3-1.3-1.51.21.21.21.10.81.41.81.01.51.3-1.5
Patch foraging indifference point 0 sec2.85.18.3-2.32.72.7-2.2-2.02.9-2.82.82.82.0-2.8-2.8-2.8-2.7-2.7-1.1-0.9-0.8-0.8-0.61.0
Patch foraging indifference point AUC0.50.81.50.7-1.0-1.00.40.7-1.21.0-1.0-1.0-0.71.11.11.10.91.10.30.20.50.10.1-1.2
Delay disc. indifference point, 0s delay1.31.43.9-0.71.21.2-0.4-0.91.7-1.51.51.50.2-1.6-1.6-1.6-1.6-2.00.60.50.80.71.00.2
Delay disc. indifference point, 16s delay0.20.30.80.6-0.3-0.40.90.5-0.50.5-0.5-0.5-0.50.40.40.40.60.30.50.50.60.50.4-0.6
Delay disc. indifference point, 2s delay0.30.30.8-0.20.50.50.2-0.50.7-0.60.60.6-0.1-0.7-0.7-0.7-0.6-0.90.40.30.80.50.6-0.5
Delay disc. indifference point, 24s delay0.10.20.6-0.60.50.5-0.2-0.80.4-0.30.30.30.3-0.4-0.4-0.4-0.3-0.3-0.2-0.4-0.4-0.3-0.20.3
Delay disc. indifference point, 4s delay0.50.51.40.8-0.5-0.51.10.6-0.20.4-0.4-0.4-1.00.30.20.30.3-0.11.11.01.11.11.2-0.6
Delay disc. indifference point, 8s delay0.20.30.8-0.60.20.1-0.3-0.90.3-0.10.10.10.6-0.1-0.1-0.00.10.2-0.7-0.9-0.9-0.8-0.80.8
Indifference point function ln k0.10.10.3-0.20.30.3-0.1-0.10.6-0.40.40.40.4-0.4-0.4-0.4-0.4-0.3-0.3-0.1-0.4-0.1-0.20.4
Indifference point function log k0.10.10.3-0.20.30.3-0.1-0.10.6-0.40.40.40.4-0.4-0.4-0.4-0.4-0.3-0.3-0.1-0.4-0.1-0.20.4
Patch foraging total patch changes 0 sec2.44.67.4-2.22.52.6-2.2-1.92.7-2.62.62.61.9-2.6-2.6-2.6-2.5-2.5-1.1-0.9-0.7-0.8-0.60.9
Patch foraging total patch changes 12 sec1.82.33.5-1.81.61.6-1.8-1.91.4-1.61.61.61.7-1.5-1.5-1.5-1.4-1.1-1.5-1.5-1.2-1.4-1.31.2
Patch foraging total patch changes 18 sec0.00.00.1-0.20.20.2-0.2-0.30.2-0.10.10.1-0.0-0.2-0.2-0.2-0.1-0.30.10.0-0.00.10.2-0.2
Patch foraging total patch changes 24 sec0.30.51.1-0.71.01.0-0.8-0.70.9-0.80.80.80.4-0.9-0.9-0.9-0.7-1.0-0.0-0.10.2-0.10.1-0.8
Patch foraging total patch changes 6 sec1.62.53.7-1.61.91.9-1.9-1.31.9-1.91.91.91.4-1.9-1.9-1.9-1.8-1.8-0.9-0.7-0.3-0.8-0.50.8
Patch foraging time to switch 0 sec0.20.41.0-0.40.60.7-0.1-0.40.8-0.70.70.70.1-0.8-0.8-0.8-0.8-1.00.30.30.50.40.50.2
Patch foraging water rate 0 sec0.51.02.3-1.20.70.7-1.3-1.10.5-0.70.70.71.3-0.6-0.6-0.6-0.5-0.2-1.3-1.3-1.5-1.4-1.31.4
Patch foraging water rate 12 sec0.61.32.5-1.31.11.1-1.5-1.20.8-0.90.90.91.5-0.8-0.8-0.8-0.9-0.3-1.5-1.3-1.6-1.4-1.40.9
Patch foraging water rate 18 sec0.91.44.5-0.8-0.0-0.1-1.1-0.9-0.60.3-0.3-0.31.20.60.60.50.71.3-1.9-1.9-2.1-2.0-2.10.8
Patch foraging water rate 24 sec2.83.910.5-2.21.11.0-2.2-2.30.5-0.90.90.92.4-0.6-0.5-0.6-0.30.4-2.9-3.0-3.2-3.0-3.02.9
Patch foraging water rate 6 sec0.50.82.10.2-0.7-0.8-0.20.3-1.10.8-0.8-0.80.21.01.11.01.11.4-0.9-0.8-1.3-0.9-1.1-0.0
Seeking ratio, delayed vs. immediate footshock1.31.64.51.6-0.9-0.91.51.7-0.71.1-1.1-1.1-1.41.00.91.00.90.51.41.51.41.41.3-2.1
Distance traveled before self-admin1.11.51.91.4-1.4-1.41.21.3-1.31.4-1.4-1.4-1.31.31.31.31.31.11.00.90.90.90.8-0.9
Distance traveled after self-admin0.00.00.10.0-0.0-0.10.2-0.2-0.30.2-0.2-0.2-0.10.10.10.20.20.10.0-0.1-0.2-0.00.0-0.2
Extensor digitorum longus weight4.517.725.1-5.04.54.5-4.6-5.04.1-4.54.54.54.8-4.2-4.2-4.3-4.0-3.1-4.1-3.9-3.4-3.7-3.53.5
Bone: elastic displacement0.00.00.10.00.00.10.20.00.1-0.00.00.0-0.0-0.1-0.1-0.10.1-0.20.10.2-0.30.30.20.2
Bone: elastic work0.60.81.8-0.81.11.1-0.5-0.81.3-1.11.11.10.5-1.2-1.2-1.2-1.0-1.3-0.0-0.0-0.10.10.20.9
Bone: endosteal estimation0.51.02.3-0.71.31.3-0.9-0.51.5-1.21.21.20.6-1.3-1.3-1.3-0.8-1.5-0.00.00.7-0.00.2-0.8
Bone: endosteal perimeter0.51.13.11.1-0.5-0.51.01.3-0.20.5-0.5-0.5-1.20.30.30.30.4-0.21.41.51.81.51.5-1.8
Epididymis fat weight0.10.51.2-0.2-0.4-0.5-0.6-0.2-0.60.6-0.6-0.60.30.70.80.70.81.1-0.8-0.9-0.9-1.0-1.00.1
Delta time in closed arm before/after self-admin2.32.25.6-1.71.11.0-1.7-1.70.7-0.80.80.82.0-0.6-0.6-0.7-0.50.2-2.3-2.3-2.2-2.3-2.40.7
Delta time in open arm before/after self-admin0.60.61.3-1.00.80.8-0.7-1.20.7-0.80.80.80.7-0.8-0.8-0.7-0.7-0.6-0.6-0.7-0.7-0.6-0.51.1
Diff in mean of infusions in LGA sessions1.51.82.81.4-1.7-1.71.11.5-1.61.6-1.6-1.6-1.31.61.61.61.61.50.80.80.50.70.6-0.8
Delay discount exponential model param0.00.00.2-0.00.10.1-0.50.3-0.1-0.10.10.10.2-0.1-0.0-0.1-0.2-0.0-0.20.0-0.1-0.1-0.10.1
Extinction: sum of active levers before priming1.31.43.00.9-1.4-1.40.31.1-1.51.5-1.5-1.5-0.71.61.61.61.51.70.00.1-0.3-0.2-0.3-0.6
Active lever presses in extinction session 60.20.20.50.5-0.5-0.50.10.7-0.30.3-0.3-0.3-0.60.30.30.30.20.10.60.60.60.50.6-0.2
Bone: final force2.33.67.7-1.52.42.5-1.7-1.22.5-2.42.42.41.1-2.5-2.6-2.5-2.2-2.8-0.1-0.00.70.00.40.4
Bone: final moment2.23.57.7-1.52.42.4-1.6-1.22.5-2.32.32.31.1-2.5-2.6-2.5-2.2-2.8-0.1-0.00.70.00.40.5
Food consumed during 24 hour testing period0.30.31.6-0.60.60.6-0.1-0.70.6-0.70.70.70.5-0.7-0.7-0.7-0.1-0.6-0.4-0.4-0.3-0.3-0.31.3
Glucose1.11.73.1-1.71.61.6-1.6-1.81.2-1.41.41.41.3-1.4-1.4-1.4-1.3-1.2-1.0-1.1-0.8-1.0-0.80.2
Heart weight0.20.30.90.3-0.7-0.80.20.3-0.70.7-0.7-0.7-0.10.80.80.70.71.0-0.3-0.2-0.6-0.3-0.4-0.1
Delay discount hyperbolic model param0.10.10.20.2-0.3-0.3-0.30.5-0.40.2-0.2-0.20.00.30.40.30.20.4-0.2-0.0-0.3-0.2-0.30.1
Intermittent access intake day 1-15 change0.20.41.00.4-0.7-0.7-0.20.6-0.70.8-0.8-0.8-0.20.80.90.80.91.0-0.2-0.1-0.6-0.3-0.4-0.4
Intermittent access intake escalation0.20.41.00.3-0.6-0.7-0.10.5-0.80.7-0.7-0.7-0.10.80.80.80.91.0-0.3-0.2-0.7-0.4-0.5-0.3
Intermittent access intake escalation 20.50.51.10.6-0.8-0.80.30.7-1.00.9-0.9-0.9-0.50.90.90.90.91.00.20.2-0.20.10.0-0.8
Intermitt. access day 1 inactive lever presses0.31.02.40.0-0.9-0.9-0.30.1-1.50.9-0.9-0.90.31.11.11.11.31.6-0.9-0.9-1.3-1.1-1.20.9
Intermitt. access day 15 inactive lever presses0.51.01.80.9-1.3-1.30.90.7-1.21.2-1.2-1.2-0.81.21.21.21.31.20.40.3-0.20.30.20.6
Intermitt. access escalation Index0.20.30.60.30.30.30.60.30.2-0.40.40.4-0.3-0.5-0.5-0.5-0.5-0.80.60.70.80.80.8-0.2
Intermittent access day 1 total infusions0.10.20.5-0.50.50.5-0.3-0.30.5-0.50.50.50.7-0.5-0.5-0.5-0.6-0.3-0.6-0.4-0.7-0.4-0.60.3
Intermittent access day 15 total infusions0.00.00.10.00.20.2-0.10.40.3-0.20.20.20.1-0.2-0.2-0.2-0.3-0.2-0.10.2-0.30.1-0.0-0.1
Intermittent access terminal intake (last 3 days)0.10.10.50.40.10.10.20.70.4-0.10.10.1-0.3-0.1-0.2-0.2-0.3-0.40.50.70.30.60.6-0.4
Intermittent access total infusions0.20.20.7-0.20.40.5-0.40.10.8-0.50.50.50.3-0.5-0.5-0.5-0.7-0.5-0.10.1-0.30.0-0.00.2
Intermittent access day 1 locomotion0.20.31.7-0.50.10.1-0.5-0.3-0.1-0.10.10.10.7-0.00.0-0.00.00.3-0.9-0.8-1.3-0.9-1.00.6
Intermittent access day 15 total locomotion0.10.20.60.3-0.4-0.40.10.7-0.20.4-0.4-0.40.10.40.50.40.40.6-0.30.0-0.8-0.1-0.4-0.1
Intermittent access total locomotion0.10.10.40.1-0.3-0.3-0.00.40.00.3-0.3-0.3-0.00.30.30.30.30.4-0.2-0.0-0.6-0.1-0.3-0.1
Intermittent access standard deviation0.40.72.31.2-0.8-0.81.01.5-0.70.7-0.7-0.7-0.90.60.70.60.60.40.91.20.71.00.8-0.7
Left kidney weight0.00.10.4-0.1-0.1-0.10.3-0.3-0.20.1-0.1-0.10.20.20.20.20.60.3-0.3-0.5-0.4-0.4-0.40.6
Right kidney weight0.20.72.00.6-1.0-1.00.70.4-1.11.0-1.0-1.0-0.41.11.11.11.41.2-0.1-0.3-0.3-0.3-0.40.9
Cocaine induced anxiety1.52.24.81.7-1.2-1.11.21.8-1.01.1-1.1-1.1-1.91.01.01.00.80.32.02.02.21.81.9-2.1
Post-drug Anxiety1.92.07.51.3-0.4-0.41.01.5-0.30.5-0.5-0.5-1.70.30.20.30.0-0.52.22.12.62.12.3-2.7
Baseline Anxiety0.00.00.1-0.10.20.20.1-0.20.1-0.20.20.20.1-0.2-0.2-0.2-0.2-0.2-0.0-0.00.00.00.0-0.1
Tail length2.911.418.93.6-4.0-4.03.63.3-4.24.0-4.0-4.0-3.24.04.04.14.33.72.11.70.91.61.3-0.8
Length with tail1.25.411.12.2-2.7-2.82.51.8-3.02.9-2.9-2.9-1.92.92.92.93.32.90.90.5-0.10.50.30.1
Length without tail0.20.81.4-1.00.90.9-0.8-1.10.7-0.70.70.71.1-0.7-0.6-0.7-0.5-0.3-1.1-1.2-1.0-1.1-1.10.9
Times rat made contact with spout1.21.42.3-1.51.11.1-1.4-1.50.8-1.01.01.01.4-0.9-0.9-0.9-0.7-0.5-1.3-1.4-1.4-1.3-1.21.4
Lifetime Intake0.70.82.2-0.71.11.1-0.8-0.21.5-1.11.11.10.7-1.2-1.2-1.2-1.3-1.2-0.30.0-0.4-0.1-0.10.2
Liver weight, left0.30.61.9-0.90.70.7-0.7-0.80.9-0.70.70.70.8-0.7-0.7-0.7-0.4-0.5-0.7-0.7-0.6-0.6-0.61.4
Liver weight, right0.20.30.80.1-0.4-0.50.2-0.2-0.90.7-0.7-0.7-0.10.70.70.70.90.9-0.2-0.5-0.4-0.5-0.40.0
Locomotor activity3.04.77.32.6-2.3-2.32.72.5-1.92.2-2.2-2.2-2.62.12.02.12.31.42.32.21.42.22.1-0.8
Locomotor testing distance1.32.33.41.8-1.5-1.51.81.8-1.21.5-1.5-1.5-1.91.41.31.41.40.91.71.71.31.61.6-0.9
Locomotor testing rearing0.00.10.3-0.1-0.1-0.1-0.0-0.2-0.30.3-0.3-0.30.10.30.30.30.60.4-0.2-0.3-0.6-0.3-0.30.5
Locomotion in novel chamber0.10.10.3-0.30.40.4-0.6-0.00.1-0.40.40.40.3-0.4-0.4-0.4-0.3-0.4-0.2-0.0-0.0-0.2-0.1-0.2
Locomotion in novel chamber post-restriction3.15.07.42.4-2.4-2.52.12.3-2.72.6-2.6-2.6-2.32.52.52.52.42.21.71.51.41.41.3-2.4
Fecal boli incidents, locomotor time 10.60.91.8-1.21.00.9-1.2-1.30.3-0.60.60.61.2-0.6-0.6-0.6-0.5-0.2-1.3-1.3-1.3-1.3-1.30.6
Change in fecal boli incidents, locomotor task1.01.02.51.2-0.7-0.61.31.1-0.50.4-0.4-0.4-1.30.30.30.30.2-0.21.51.51.51.61.6-0.7
Time >=10cm from walls, locomotor time 10.60.61.7-0.30.80.80.1-0.20.9-0.90.90.90.0-1.0-1.0-1.0-0.9-1.30.50.60.70.70.8-0.0
Bouts of movement, locomotor time 10.60.71.20.9-1.0-1.01.00.7-1.01.0-1.0-1.0-0.71.01.01.01.11.00.30.30.10.30.20.2
Total resting periods, locomotor time 11.21.42.11.3-1.4-1.41.41.1-1.31.4-1.4-1.4-1.11.41.41.41.51.20.70.60.40.60.5-0.3
Rest time, locomotor task time 10.50.61.10.9-0.8-0.80.90.7-0.90.8-0.8-0.8-1.00.70.70.70.80.41.00.80.70.90.9-0.5
Distance moved, locomotor task time 10.71.02.6-0.50.91.0-0.6-0.21.5-1.21.21.20.2-1.3-1.3-1.3-1.4-1.60.40.60.70.60.70.1
Vertical activity count, locomotor time 10.61.43.0-1.31.21.3-1.6-0.81.7-1.41.41.41.3-1.3-1.3-1.3-1.4-1.1-1.0-0.7-0.6-0.8-0.70.6
Time >=10cm from walls, locomotor time 20.71.01.7-1.21.21.2-1.0-1.10.8-1.01.01.01.3-1.0-0.9-1.0-0.9-0.6-1.2-1.1-0.9-1.1-1.10.3
Bouts of movement, locomotor time 20.30.51.40.8-0.4-0.41.20.7-0.20.3-0.3-0.3-0.90.10.10.20.3-0.21.11.10.91.21.10.3
Total resting periods, locomotor time 20.30.61.80.9-0.4-0.31.20.7-0.20.2-0.2-0.2-0.90.10.00.10.2-0.41.21.21.11.31.30.2
Rest time, locomotor task time 20.20.31.00.6-0.1-0.10.90.5-0.30.2-0.2-0.2-0.70.0-0.00.10.1-0.30.90.90.81.01.0-0.3
Distance moved, locomotor task time 20.20.21.0-0.4-0.0-0.0-0.6-0.30.2-0.00.00.00.50.10.10.00.00.4-0.8-0.7-1.0-0.8-0.80.8
Vertical activity count, locomotor time 21.21.63.0-1.51.00.9-1.6-1.41.0-1.01.01.01.6-0.8-0.8-0.8-0.8-0.2-1.7-1.6-1.7-1.7-1.71.3
Light reinforcement 12.35.69.32.9-2.7-2.63.12.8-2.22.5-2.5-2.5-2.72.42.42.42.41.82.32.31.12.32.0-0.7
Light reinforcement 20.91.53.51.4-1.4-1.41.91.2-1.21.3-1.3-1.3-1.31.21.21.21.40.91.11.00.11.20.90.6
Bone: marrow area0.40.92.0-0.71.31.3-0.9-0.41.4-1.11.11.10.5-1.2-1.2-1.2-0.7-1.4-0.00.00.7-0.00.2-1.0
Bone: maximum diameter0.81.55.41.3-0.5-0.50.91.6-0.20.5-0.5-0.5-1.40.30.30.30.4-0.41.71.92.31.81.8-2.2
Bone: maximum force2.13.87.4-1.72.52.5-1.8-1.42.6-2.42.42.41.3-2.6-2.6-2.5-2.3-2.7-0.3-0.20.5-0.20.20.5
Bone: maximum moment2.23.87.3-1.72.52.5-1.8-1.42.6-2.42.42.41.3-2.6-2.6-2.5-2.2-2.7-0.3-0.20.4-0.20.20.6
Mean time between licks in bursts0.30.71.41.0-1.1-1.20.81.2-1.00.9-0.9-0.9-0.71.01.11.01.01.00.40.50.30.30.2-0.1
Mean num. licks in bursts0.40.71.31.0-0.8-0.81.20.9-0.80.8-0.8-0.8-1.00.70.70.80.80.50.91.00.21.00.8-0.2
Cd content in liver0.20.20.80.6-0.5-0.50.20.8-0.30.4-0.4-0.4-0.50.40.40.30.10.30.40.60.70.50.4-0.9
Co content in liver2.22.64.41.7-2.1-2.11.81.5-1.91.9-1.9-1.9-1.42.02.02.01.91.90.70.70.10.70.40.3
Cu content in liver0.60.71.9-0.10.80.8-0.30.21.0-0.90.90.9-0.0-1.0-1.0-1.0-0.9-1.40.60.91.20.90.9-0.8
Fe content in liver0.30.30.9-0.60.50.4-1.0-0.40.6-0.50.50.50.7-0.4-0.4-0.4-0.5-0.2-0.7-0.6-0.6-0.7-0.70.4
K content in liver0.90.91.81.1-0.7-0.71.31.1-0.50.7-0.7-0.7-1.20.60.50.60.60.21.31.31.11.41.2-0.7
Mg content in liver1.21.21.71.2-1.1-1.11.31.1-1.01.1-1.1-1.1-1.31.01.01.01.00.61.21.11.21.11.1-0.8
Mn content in liver2.62.98.01.9-1.1-1.01.92.0-0.50.8-0.8-0.8-2.20.60.50.60.6-0.42.62.72.82.62.7-1.6
Na content in liver0.30.31.8-0.20.60.6-0.3-0.20.4-0.40.40.4-0.2-0.5-0.5-0.5-0.7-0.70.50.40.50.40.6-1.4
Rb content in liver0.50.62.00.10.60.70.20.30.7-0.70.70.7-0.2-0.8-0.8-0.8-0.7-1.20.80.91.40.91.0-1.0
Se content in liver0.00.00.60.00.00.0-0.30.10.00.1-0.1-0.1-0.00.10.10.0-0.10.00.00.10.30.00.0-0.8
Sr content in liver0.20.20.40.2-0.4-0.4-0.00.3-0.30.4-0.4-0.40.10.50.50.50.50.7-0.4-0.3-0.6-0.4-0.50.5
Zn content in liver2.62.96.71.2-1.9-2.00.91.1-2.42.2-2.2-2.2-0.72.32.32.22.32.6-0.2-0.3-0.5-0.5-0.7-0.4
Bone: minimum diameter0.40.71.7-0.00.70.8-0.20.21.0-0.80.80.8-0.1-0.9-0.9-0.9-0.8-1.30.70.91.30.80.9-0.9
Time in familiar zone, hab. session 14.13.96.61.9-2.2-2.21.81.8-2.52.5-2.5-2.5-1.72.42.42.42.62.31.00.80.50.70.5-1.7
Time in novel zone, hab. session 12.92.95.9-1.41.81.9-1.3-1.22.3-2.22.22.21.0-2.3-2.3-2.2-2.3-2.4-0.2-0.00.20.00.31.4
Total zone transitions, hab. session 10.81.13.01.0-0.7-0.71.01.0-0.30.5-0.5-0.5-1.40.30.30.40.3-0.31.71.61.61.71.7-1.1
Total locomotion distance, hab. session 12.33.37.72.1-1.5-1.42.12.0-0.91.1-1.1-1.1-2.40.90.80.90.9-0.02.82.72.52.72.8-1.5
Locomotion velocity, hab. session 12.23.16.22.0-1.6-1.62.11.9-1.11.3-1.3-1.3-2.31.11.11.11.00.32.52.42.12.52.4-1.4
Time in familiar zone, hab. session 24.14.47.82.1-2.6-2.62.21.9-2.72.5-2.5-2.5-1.62.62.72.62.82.70.70.6-0.10.50.2-0.1
Time in novel zone, hab. session 24.74.88.8-2.12.62.7-2.2-1.92.8-2.72.72.71.5-2.8-2.8-2.8-3.0-2.9-0.5-0.40.3-0.40.0-0.1
Total zone transitions, hab. session 21.01.23.3-0.10.70.80.10.01.3-1.11.11.1-0.4-1.3-1.3-1.2-1.4-1.81.21.41.31.51.50.0
Total locomotion distance, hab. session 20.70.92.71.0-0.8-0.71.40.9-0.30.5-0.5-0.5-1.30.30.30.30.5-0.21.51.51.21.61.6-0.1
Locomotion velocity, hab. session 20.91.23.91.2-0.8-0.81.61.0-0.30.5-0.5-0.5-1.50.30.20.30.5-0.41.81.81.52.01.9-0.2
Novel to familiar place preference ratio2.42.65.6-1.41.91.9-1.4-1.32.2-2.02.02.00.8-2.1-2.2-2.1-2.1-2.40.10.00.50.10.50.3
Novelty place preference1.61.74.1-1.01.51.5-1.1-0.91.8-1.71.71.70.6-1.8-1.8-1.7-1.7-2.00.20.20.60.20.60.1
Time in novel zone, NPP test2.12.34.8-1.31.71.8-1.3-1.12.0-1.91.91.90.8-2.0-2.0-2.0-2.0-2.2-0.0-0.00.40.10.40.3
Total zone transitions, NPP test0.30.51.4-0.40.50.6-0.0-0.50.9-0.80.80.8-0.0-0.9-0.9-0.9-0.8-1.20.50.50.40.70.70.6
Total locomotion distance, NPP test0.30.41.50.3-0.00.00.70.00.5-0.30.30.3-0.6-0.5-0.5-0.4-0.4-0.91.11.00.81.21.20.4
Locomotion velocity, NPP test0.30.41.70.5-0.3-0.31.00.30.10.0-0.0-0.0-0.9-0.1-0.1-0.10.0-0.51.21.10.81.31.30.2
Intraocular pressure0.60.82.10.0-0.8-0.80.3-0.4-1.10.9-0.9-0.90.21.01.01.01.11.4-0.8-1.1-1.2-1.0-1.00.6
Delta distance traveled before/after self-admin0.50.50.9-0.90.90.8-0.7-1.00.6-0.70.70.70.9-0.7-0.7-0.7-0.7-0.5-0.8-0.8-0.8-0.7-0.70.2
Delta ambulatory time before/after self-admin0.40.50.8-0.70.90.9-0.5-0.70.8-0.80.80.80.6-0.9-0.9-0.9-0.9-0.9-0.3-0.3-0.2-0.2-0.20.1
Parametrial fat weight0.40.81.7-0.91.31.3-0.8-0.90.9-1.11.11.10.8-1.1-1.1-1.1-1.1-1.1-0.4-0.4-0.1-0.3-0.2-0.1
Pavlov. Cond. lever latency0.60.72.9-0.70.30.3-0.6-0.7-0.30.1-0.1-0.11.00.20.20.20.40.7-1.4-1.4-1.7-1.5-1.50.7
Pavlov. Cond. magazine entry latency1.31.62.71.5-1.6-1.71.31.4-1.31.4-1.4-1.4-1.31.41.41.41.41.20.90.90.90.90.7-0.5
Pavlov. Cond. change in total contacts0.20.20.3-0.30.30.3-0.5-0.10.6-0.60.60.60.3-0.5-0.5-0.5-0.5-0.5-0.1-0.00.5-0.1-0.0-0.0
Pavlov. Cond. index score0.60.71.61.0-1.0-0.91.01.0-0.50.6-0.6-0.6-1.10.60.60.50.40.21.11.21.31.21.1-0.3
Pavlov. Cond. latency score0.81.02.61.2-0.9-0.91.11.2-0.40.5-0.5-0.5-1.30.50.50.50.3-0.01.41.51.61.51.5-0.7
Pavlov. Cond. lever contacts0.40.52.00.4-0.2-0.10.40.40.5-0.30.30.3-0.7-0.3-0.4-0.3-0.6-0.81.21.21.41.21.3-0.2
Pavlov. Cond. magazine entry number0.60.71.3-0.91.11.1-0.7-0.80.9-0.90.90.90.8-1.0-1.0-1.0-1.0-0.9-0.5-0.5-0.7-0.4-0.40.4
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.1-0.2-0.2-0.2-0.1-0.50.4-0.4-0.40.30.50.50.50.60.8-0.7-0.8-0.9-0.9-0.90.4
Pavlov. Cond. lever-magazine prob. diff.0.60.71.51.0-1.0-1.00.91.1-0.50.6-0.6-0.6-1.10.60.60.60.50.31.11.11.21.11.1-0.4
Pavlov. Cond. response bias0.50.61.10.9-1.0-1.00.70.8-0.70.8-0.8-0.8-0.80.90.90.80.70.70.60.50.80.50.5-0.4
Pavlov. Cond. lever latency1.41.93.4-1.51.51.5-1.7-1.31.5-1.71.71.71.4-1.6-1.6-1.6-1.9-1.4-1.0-0.7-0.6-0.7-0.70.7
Pavlov. Cond. magazine entry latency2.12.54.21.8-1.9-1.91.91.5-1.61.8-1.8-1.8-1.71.81.71.82.11.51.31.01.01.01.0-0.4
Pavlov. Cond. change in total contacts0.50.91.91.0-1.1-1.11.00.9-0.91.1-1.1-1.1-0.81.11.11.11.41.10.50.40.20.30.3-0.1
Pavlov. Cond. index score1.72.34.31.7-1.7-1.71.81.5-1.61.8-1.8-1.8-1.51.71.71.72.11.51.00.80.70.80.7-0.6
Pavlov. Cond. latency score1.92.64.31.8-1.8-1.81.91.6-1.71.8-1.8-1.8-1.71.81.81.82.11.51.31.00.91.01.0-0.7
Pavlov. Cond. lever contacts1.31.83.71.4-1.5-1.51.51.2-1.51.6-1.6-1.6-1.21.61.61.61.91.50.70.50.40.40.4-0.6
Pavlov. Cond. magazine entry number2.12.64.2-1.91.91.9-1.9-1.71.6-1.81.81.81.7-1.7-1.7-1.7-2.0-1.4-1.3-1.1-1.2-1.1-1.10.6
Pavlov. Cond. intertrial magazine entries0.91.42.2-1.51.41.3-1.5-1.40.9-1.11.11.11.4-1.0-1.0-1.0-1.2-0.7-1.3-1.3-1.3-1.3-1.20.4
Pavlov. Cond. lever-magazine prob. diff.1.92.54.41.8-1.8-1.81.91.7-1.71.8-1.8-1.8-1.61.81.81.82.11.51.21.01.00.90.9-0.8
Pavlov. Cond. response bias2.02.75.51.7-1.9-1.91.81.5-1.92.0-2.0-2.0-1.52.02.02.02.31.90.90.60.50.50.5-0.7
Time in closed arm before self-admin0.30.41.00.20.50.50.50.20.5-0.40.40.4-0.3-0.6-0.6-0.5-0.5-0.90.70.81.00.90.9-0.5
Time in closed arm after self-admin0.50.51.2-0.61.11.0-0.3-0.40.8-0.90.90.90.9-0.8-0.8-0.9-0.8-0.7-0.7-0.4-0.2-0.4-0.5-0.8
Time in open arm before self-admin0.00.00.2-0.0-0.2-0.1-0.40.20.0-0.10.10.10.1-0.00.0-0.1-0.10.0-0.20.0-0.2-0.1-0.10.4
Time in open arm after self-admin1.61.74.8-1.61.01.1-1.5-1.71.0-1.21.21.21.4-1.1-1.1-1.1-1.1-0.8-1.2-1.4-1.5-1.2-1.12.2
Bone: periosteal estimation0.91.94.9-0.61.61.6-0.9-0.21.9-1.61.61.60.3-1.8-1.8-1.8-1.4-2.20.60.71.50.71.0-0.8
Bone: periosteal perimeter0.50.93.30.60.20.30.40.80.6-0.30.30.3-0.8-0.5-0.5-0.5-0.5-1.11.31.51.81.51.6-1.2
Bone: post-yield work0.40.61.1-0.91.11.0-1.0-0.90.9-0.90.90.90.8-0.9-0.9-0.9-0.5-0.8-0.5-0.7-0.1-0.7-0.40.0
Progressive ratio test 1 active lever presses0.40.51.0-0.80.70.7-1.0-0.61.0-0.70.70.70.8-0.7-0.7-0.7-0.8-0.5-0.7-0.5-0.8-0.6-0.60.5
Progressive ratio test 1 breakpoint0.50.61.1-0.90.70.7-1.0-0.60.9-0.70.70.70.9-0.7-0.7-0.7-0.8-0.5-0.7-0.6-0.9-0.7-0.60.6
Progressive ratio test 1 inactive lever presses0.10.10.50.4-0.4-0.30.20.7-0.20.3-0.3-0.3-0.30.30.30.30.20.20.20.4-0.00.30.2-0.1
Progressive ratio test 2 active lever presses0.00.00.20.1-0.2-0.2-0.10.40.30.1-0.1-0.1-0.10.10.10.10.00.00.10.3-0.30.10.10.3
Progressive ratio test 2 breakpoint0.10.10.20.3-0.4-0.30.00.50.20.3-0.3-0.3-0.30.20.20.20.20.10.20.3-0.20.20.20.3
Progressive ratio test 2 inactive lever presses0.20.31.1-0.20.30.4-0.50.11.1-0.50.50.50.0-0.6-0.6-0.6-0.7-0.80.30.4-0.20.30.40.4
Incentive Sensitization - Responses0.30.40.70.6-0.9-0.80.50.6-0.50.8-0.8-0.8-0.60.70.70.70.70.70.30.3-0.10.30.20.3
Incentive Sensitization - Breakpoint0.40.50.90.8-1.0-0.90.80.8-0.60.8-0.8-0.8-0.80.80.80.80.80.70.60.50.10.50.40.2
Sum of active levers in priming session hrs 5-60.10.10.60.2-0.3-0.3-0.00.3-0.40.4-0.4-0.4-0.20.40.40.40.40.40.10.10.1-0.00.0-0.8
Progressive ratio1.11.73.7-1.41.21.2-1.3-1.31.0-1.31.31.31.5-1.2-1.2-1.2-1.1-0.8-1.4-1.2-1.5-1.2-1.21.9
Food seeking constrained by brief footshock1.72.03.21.3-1.7-1.71.31.0-1.81.8-1.8-1.8-1.41.81.71.81.71.60.90.60.60.60.6-0.8
Seeking ratio, punishment vs. effort2.23.24.51.8-1.9-2.01.71.5-1.92.1-2.1-2.1-1.92.12.02.12.01.71.41.11.41.11.1-2.1
Retroperitoneal fat weight2.18.913.2-3.63.33.2-3.6-3.62.3-2.92.92.93.6-2.7-2.7-2.7-2.5-1.8-3.3-3.2-2.8-3.2-2.91.9
Reaction time number correct0.81.53.1-1.51.11.1-1.4-1.60.7-0.90.90.91.5-0.8-0.7-0.8-0.6-0.3-1.6-1.7-1.8-1.7-1.61.0
Reaction time mean minus median0.61.52.11.4-1.2-1.21.41.3-1.41.3-1.3-1.3-1.31.31.31.31.41.01.01.01.21.00.9-1.3
Reaction time mean minus median AUC1.02.45.51.8-1.2-1.11.91.8-1.01.1-1.1-1.1-2.01.00.91.01.00.32.12.02.42.02.0-1.9
Reaction time num false alarms0.71.05.4-1.00.70.7-0.5-1.20.8-1.01.01.01.0-0.9-0.9-0.9-0.6-0.6-0.8-0.8-1.3-0.7-0.72.3
Reaction time num false alarms AUC0.71.16.3-1.10.70.7-0.6-1.30.7-0.90.90.91.1-0.8-0.8-0.8-0.5-0.5-1.0-1.1-1.5-0.9-1.02.5
Reaction time trials correct on left0.81.53.1-1.51.11.1-1.4-1.60.7-0.90.90.91.5-0.8-0.7-0.8-0.6-0.3-1.6-1.7-1.8-1.7-1.61.0
Reaction time trials on left0.71.42.7-1.41.11.0-1.4-1.50.7-0.90.90.91.5-0.8-0.7-0.8-0.6-0.3-1.5-1.6-1.7-1.6-1.50.9
Reaction time mean1.21.93.61.6-1.2-1.11.61.6-1.01.1-1.1-1.1-1.71.01.01.00.90.51.71.71.91.71.6-1.9
Reaction time mean AUC0.71.13.81.2-0.7-0.61.01.2-0.50.6-0.6-0.6-1.20.50.50.50.40.11.31.41.81.41.4-2.0
Median of all reaction times0.91.22.71.3-0.9-0.91.21.3-0.60.8-0.8-0.8-1.40.70.70.70.60.21.41.51.61.51.4-1.5
Reaction time omissions0.20.31.40.40.20.20.20.50.2-0.20.20.2-0.4-0.3-0.3-0.3-0.3-0.60.70.81.00.80.8-1.2
Reaction time false alarm rate0.20.22.5-0.30.20.20.2-0.40.4-0.50.50.50.2-0.5-0.5-0.5-0.3-0.5-0.0-0.0-0.30.10.01.6
Reaction time premature initiation rate1.11.63.20.9-1.4-1.41.10.7-1.71.6-1.6-1.6-0.71.61.61.61.81.80.1-0.1-0.8-0.1-0.30.8
Reaction time premature initiations0.71.22.90.1-0.8-0.80.2-0.1-1.31.1-1.1-1.10.11.21.21.21.41.7-0.8-1.1-1.7-1.0-1.21.1
Std. dev. reaction times0.61.22.61.2-0.8-0.81.21.2-0.90.9-0.9-0.9-1.30.80.80.80.80.41.31.31.61.21.2-1.6
Reaction time trials completed0.71.42.7-1.41.11.0-1.4-1.50.7-0.90.90.91.5-0.8-0.7-0.8-0.6-0.3-1.5-1.6-1.7-1.6-1.50.9
Reaction time trials AUC0.91.73.9-1.61.11.1-1.5-1.70.7-0.90.90.91.6-0.8-0.8-0.8-0.6-0.2-1.8-1.9-2.0-1.8-1.71.2
Run reversals in cocaine runway, females2.62.63.82.0-1.7-1.71.91.9-1.61.6-1.6-1.6-1.91.51.51.51.31.01.81.71.61.61.6-1.0
Run reversals in cocaine runway, males2.52.56.81.9-1.3-1.31.62.0-1.31.4-1.4-1.4-1.81.31.31.30.90.81.81.81.91.71.6-2.6
Latency to leave start box in cocaine runway0.50.51.80.30.30.40.50.10.9-0.40.40.4-0.6-0.6-0.6-0.5-0.5-1.01.11.01.41.11.2-0.2
Latency to leave start box in cocaine runway, F0.91.03.70.40.50.50.60.21.0-0.50.50.5-0.8-0.8-0.8-0.7-1.0-1.41.41.41.91.51.7-1.1
Latency to leave start box in cocaine runway, M0.20.21.2-0.3-0.0-0.0-0.3-0.40.10.0-0.0-0.00.30.10.10.10.40.2-0.4-0.5-0.7-0.5-0.51.1
Std. dev. time between licks in bursts0.81.02.31.3-0.8-0.81.11.4-0.50.6-0.6-0.6-1.30.50.50.50.50.01.51.51.41.41.5-0.9
Total sessions with >9 infusions0.60.71.7-0.51.11.1-0.70.01.3-1.01.01.00.6-1.1-1.1-1.1-1.2-1.2-0.20.2-0.20.10.0-0.5
Short access day 1 total inactive lever presses0.30.40.80.5-0.7-0.70.70.5-0.80.7-0.7-0.7-0.20.80.80.80.80.9-0.1-0.1-0.5-0.1-0.30.0
Short access day 10 total inactive lever presses0.30.72.1-0.2-0.4-0.5-0.3-0.2-1.10.5-0.5-0.50.60.70.80.70.91.2-1.2-1.1-1.4-1.2-1.40.6
Short access day 1 total infusions0.50.71.5-0.51.11.1-0.70.11.2-1.11.11.10.7-1.1-1.1-1.1-1.2-1.1-0.30.2-0.30.0-0.1-0.3
Short access day 10 total infusions0.20.30.6-0.40.60.6-0.4-0.10.5-0.60.60.60.6-0.6-0.6-0.6-0.8-0.5-0.5-0.2-0.6-0.2-0.40.0
Short access total infusions0.91.12.4-0.71.31.3-0.7-0.21.6-1.31.31.30.8-1.4-1.4-1.4-1.5-1.4-0.30.1-0.50.0-0.10.2
Short access day 1 locomotion0.20.20.90.6-0.5-0.50.41.0-0.50.5-0.5-0.5-0.20.60.60.50.70.6-0.10.3-0.40.1-0.2-0.4
Short access day 10 total locomotion0.91.74.00.9-1.4-1.50.41.3-1.91.5-1.5-1.5-0.41.71.71.61.62.0-0.4-0.1-1.1-0.4-0.8-0.5
Short access total locomotion0.20.20.60.4-0.4-0.40.10.8-0.50.5-0.5-0.5-0.00.50.50.50.50.6-0.20.1-0.6-0.1-0.3-0.6
One hour access (0.3 mA shock)0.20.30.9-0.60.40.4-1.0-0.50.7-0.40.40.40.6-0.3-0.3-0.4-0.5-0.2-0.6-0.5-0.6-0.6-0.50.4
Compulsive drug intake0.10.10.30.2-0.1-0.10.50.0-0.00.2-0.2-0.2-0.30.10.10.10.2-0.00.40.20.40.40.4-0.4
One hour access (shock baseline)0.00.10.3-0.1-0.1-0.1-0.50.30.10.1-0.1-0.10.10.10.10.1-0.00.2-0.3-0.1-0.6-0.3-0.30.2
Social response proportion0.91.12.01.2-1.1-1.11.41.1-1.21.1-1.1-1.1-1.21.01.01.10.90.71.10.90.41.00.9-0.0
Social responses8.110.514.23.7-3.5-3.53.83.6-3.53.6-3.6-3.6-3.73.33.33.43.42.63.12.82.12.82.5-1.8
Social time1.01.32.0-1.41.11.1-1.3-1.41.0-1.11.11.11.3-1.1-1.0-1.1-1.2-0.7-1.2-1.2-1.1-1.1-1.11.1
Soleus weight4.914.419.7-4.34.34.3-3.8-4.24.3-4.44.44.43.8-4.3-4.3-4.3-4.4-3.6-2.8-2.6-2.1-2.3-2.12.9
Bone: stiffness3.15.18.3-2.22.92.9-2.5-1.82.8-2.82.82.81.8-2.8-2.9-2.8-2.6-2.8-0.9-0.80.0-0.8-0.40.6
Tibialis anterior weight1.13.75.5-2.22.32.3-2.1-2.12.1-2.22.22.22.0-2.2-2.2-2.2-2.2-1.9-1.5-1.3-0.7-1.1-1.10.6
Time to tail flick, vehicle, before self-admin1.51.66.11.5-0.7-0.71.51.6-0.80.8-0.8-0.8-1.40.70.70.70.60.31.41.51.81.51.4-2.5
Time to tail flick, vehicle, after self-admin0.60.71.90.1-0.8-0.80.1-0.2-1.30.8-0.8-0.80.11.01.01.01.01.4-0.7-0.9-0.9-0.9-1.00.7
Time to tail flick, test, before self-admin1.01.02.61.2-0.8-0.71.41.2-0.30.5-0.5-0.5-1.30.40.40.40.4-0.11.51.51.61.51.5-0.6
Time to tail flick, test, after self-admin0.10.10.40.20.20.20.30.20.2-0.20.20.2-0.2-0.2-0.3-0.2-0.2-0.40.40.50.50.50.5-0.7
Delta time to tail flick, vehicle, before/after SA2.01.95.7-1.60.70.6-1.5-1.90.2-0.70.70.71.6-0.5-0.5-0.5-0.40.2-1.9-2.1-2.0-2.0-1.92.4
Delta time to tail flick, test, before/after SA0.40.41.7-0.50.10.0-0.5-0.7-0.40.2-0.2-0.20.70.30.30.30.40.7-1.0-1.1-1.3-1.1-1.10.2
Tibia length0.82.25.31.3-1.7-1.81.51.0-2.01.8-1.8-1.8-1.31.91.81.92.31.80.70.40.20.40.4-0.0
Ambulatory time before self-admin0.30.40.50.7-0.7-0.70.40.6-0.70.7-0.7-0.7-0.70.70.70.70.70.60.50.40.40.40.4-0.4
Ambulatory time after self-admin0.00.00.2-0.00.10.1-0.0-0.1-0.10.0-0.0-0.0-0.1-0.0-0.00.00.0-0.00.1-0.0-0.10.00.1-0.4
Bone: tissue strength4.44.57.3-2.22.62.6-2.3-1.92.7-2.52.52.51.9-2.6-2.6-2.6-2.5-2.5-1.1-0.9-0.6-0.8-0.60.7
Total heroin consumption2.02.33.21.7-1.7-1.71.61.6-1.61.6-1.6-1.6-1.81.61.51.61.41.21.51.41.21.31.3-1.3
Bone: trabecular number0.71.23.51.1-0.5-0.51.11.0-0.30.5-0.5-0.5-1.40.30.20.30.1-0.31.81.71.91.81.8-1.3
Bone: trabecular spacing1.31.75.7-1.00.10.0-0.9-1.0-0.2-0.10.10.11.50.20.30.20.31.1-2.2-2.1-2.4-2.1-2.42.0
Bone: trabecular thickness2.12.68.60.80.40.50.70.91.2-0.80.80.8-1.4-1.1-1.2-1.1-1.1-2.22.52.52.82.62.9-1.0
Bone: trabecular tissue density4.26.28.2-2.82.82.8-2.8-2.72.6-2.72.72.72.9-2.5-2.5-2.5-2.4-1.9-2.4-2.3-1.8-2.3-2.11.6
Water consumed over 24 hours0.50.71.7-0.70.90.9-0.3-0.71.1-1.01.01.00.3-1.1-1.2-1.1-0.8-1.30.20.20.20.30.40.5
Number of responses in last shaping day1.31.42.61.1-1.4-1.40.31.6-1.41.4-1.4-1.4-0.81.51.51.51.61.50.30.5-0.20.2-0.0-0.8