Gjd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Gjd3	0.08	0.05	8.5e-09	0.04	0.07	0.07	0.06	1.2e-04	5.1e-07	5.7e-07	1.6e-06
2	LHb	gene expression	Gjd3	0.33	0.15	7.6e-05	0.18	0.18	0.13	0.2	4.9e-05	4.1e-05	6.9e-04	1.9e-05
3	PL	gene expression	Gjd3	0.02	0.02	3.2e-03	0.02	0.02	0.02	0.02	1.1e-03	1.5e-03	1.3e-03	1.3e-03
4	Liver	gene expression	Gjd3	0.22	0.13	5.0e-14	0.07	0.08	0.13	0.07	1.9e-08	8.8e-09	1.6e-14	3.2e-08
5	NAcc	gene expression	Gjd3	0.03	0.02	7.6e-03	-0	0	-0	-0	8.9e-01	1.7e-01	8.8e-01	8.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.0	3.3	5.7	-1.9	-2.4	1.7	-0.8	-2.0
Area under the delay curve	0.2	0.2	0.6	-0.8	-0.6	0.3	-0.4	-0.0
BMI with tail	1.9	6.0	9.4	3.1	1.5	-3.0	3.0	1.0
BMI without tail	0.2	0.4	1.3	0.6	-0.3	-1.1	0.2	0.4
Body weight	3.6	15.0	21.5	4.6	3.0	-4.5	4.6	1.7
Weight adjusted by age	0.7	0.8	2.9	0.3	0.5	-0.2	1.7	-0.8
Bone surface	0.4	0.8	1.7	0.2	-1.0	-0.3	1.0	-1.3
Bone volume	0.7	1.2	2.9	0.0	-1.3	-0.2	1.1	-1.7
Breakpoint value in progressive ratio session	0.2	0.3	0.4	-0.4	0.4	0.6	0.5	-0.6
Number of licking bursts	0.6	0.7	1.8	0.2	-0.9	-0.0	0.8	-1.4
Context. condit. distance diff. score	1.6	1.9	5.7	0.4	1.8	-0.3	-0.3	2.4
Locomotion velocity, session 1	0.5	0.5	1.2	0.8	-0.1	-0.9	1.1	-0.2
Locomotion distance, session 1	2.0	2.5	4.6	1.9	0.3	-2.1	2.1	-0.0
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.0	0.1	0.2	0.1
Locomotion distance, session 2	0.6	0.9	1.6	0.6	-0.8	-0.7	1.3	-1.1
Locomotion velocity, session 3	0.3	0.4	0.9	-0.5	-0.3	0.9	-0.8	0.1
Locomotion distance, session 3	0.0	0.0	0.2	0.4	0.0	-0.2	0.0	0.1
Stereotopy head waving bouts, day 3	1.9	2.3	4.4	-2.1	-1.4	1.6	-1.4	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.5	-0.7	-0.3	0.3	0.0	0.0
Locomotion velocity, session 7	1.1	1.2	2.2	1.5	0.6	-1.2	1.3	-0.1
Locomotion distance, session 7	0.5	0.6	1.6	1.3	0.7	-0.9	0.5	0.2
Stereotopy head waving bouts, day 7	0.5	0.6	1.1	-1.0	-1.0	0.6	-0.2	-0.8
Stereotopy head waving duration, day 7	0.4	0.5	1.0	-1.0	-0.9	0.5	-0.1	-0.7
Locomotion velocity, session 8	5.4	6.4	8.8	2.6	3.0	-2.5	1.9	2.6
Locomotion distance, session 8	0.7	1.0	1.4	1.1	1.0	-1.0	1.2	0.7
Degree of sensitization distance	1.5	1.5	2.2	1.4	1.5	-1.2	0.8	1.1
Degree of sensitization stereotypy	0.7	0.7	1.2	-1.0	-1.1	0.7	-0.2	-1.0
Conditioned locomotion	0.3	0.3	0.7	-0.8	-0.3	0.4	-0.7	-0.1
Cocaine response after cond. corrected	0.8	0.9	2.3	-0.6	-1.1	0.1	0.7	-1.5
Cocaine response after cond. not corrected	1.0	1.1	3.0	-0.6	-1.2	0.2	0.8	-1.7
Cocaine response before conditioning	0.0	0.1	0.1	-0.3	-0.0	0.4	-0.2	-0.0
Saline control response	0.5	0.6	1.7	0.6	0.2	-0.9	1.3	-0.3
Bone: connectivity density	2.9	4.6	7.1	-2.3	-2.7	2.1	-1.3	-2.1
Bone: cortical apparent density	4.8	6.4	10.1	-2.8	-2.0	3.1	-3.2	-0.6
Bone: cortical area	0.1	0.1	0.3	-0.2	-0.3	0.6	0.1	-0.4
Bone: cortical porosity	0.4	0.4	1.1	-0.2	-0.7	-0.1	0.6	-1.1
Bone: cortical porosity	0.5	0.5	1.1	-0.1	-0.5	-0.4	1.0	-1.1
Bone: cortical thickness	1.0	1.7	3.1	-1.6	-1.0	1.8	-1.2	-0.3
Bone: cortical thickness	4.9	5.7	10.7	-3.3	-2.2	2.7	-1.9	-1.3
Bone: cortical tissue density	4.8	6.3	10.2	-2.7	-2.0	3.1	-3.2	-0.6
Condit. Reinf. active minus inactive responses	1.4	1.6	2.6	-1.5	-0.8	1.6	-1.6	-0.0
Condit. Reinf. active-inactive response ratio	1.9	2.0	3.7	-1.7	-0.6	1.8	-1.9	0.2
Condit. Reinf. active responses	1.2	1.5	3.0	-1.3	-0.8	1.7	-1.4	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.1	-0.3	0.5	0.3	-0.5
Incentive salience index mean	2.0	2.4	3.6	-1.6	-1.5	1.9	-1.7	-0.8
Condit. Reinf. lever presses	0.8	1.1	2.3	-0.7	-1.5	1.1	-0.7	-1.1
Condit. Reinf. active minus inactive responses	0.7	0.9	1.9	-0.7	-1.2	0.8	-0.4	-1.4
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.9	-0.4	-1.3	0.3	-0.0	-1.4
Condit. Reinf. active responses	1.3	1.8	4.0	-1.0	-1.7	1.2	-0.2	-2.0
Condit. Reinf. inactive responses	1.4	1.7	3.0	-1.2	-1.4	1.3	-0.4	-1.7
Condit. Reinf. lever presses	0.2	0.2	0.5	-0.6	-0.2	0.7	-0.3	-0.4
Condit. Reinf. lever reinforcers received	1.4	2.0	3.4	-1.2	-1.7	1.4	-0.5	-1.8
Conditioned reinforcement - actives	0.4	0.4	1.0	-0.5	-0.1	0.7	-1.0	-0.4
Conditioned reinforcement - inactives	1.1	1.2	3.0	-1.1	-0.6	1.2	-1.7	-0.3
Conditioned locomotion	0.2	0.3	0.8	-0.2	-0.6	0.2	-0.5	-0.9
Patch foraging indifference point 0 sec	1.8	2.9	5.4	-1.5	-1.3	2.1	-2.3	-0.7
Patch foraging indifference point AUC	0.0	0.0	0.1	0.2	-0.1	-0.1	0.3	-0.2
Delay disc. indifference point, 0s delay	1.0	1.1	2.3	-1.1	-1.1	1.5	-0.3	-0.8
Delay disc. indifference point, 16s delay	0.9	0.9	2.3	-1.5	-0.1	0.7	-0.9	0.8
Delay disc. indifference point, 2s delay	0.8	0.8	2.0	-0.6	-1.4	0.5	-0.1	-1.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.1	0.3	-0.5	-0.4	0.7
Delay disc. indifference point, 4s delay	0.7	0.7	1.8	-1.3	-0.8	0.8	0.1	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.2	-0.6	0.3	-0.5	-0.2
Indifference point function ln k	0.2	0.3	0.7	-0.4	0.3	0.2	-0.6	0.8
Indifference point function log k	0.2	0.3	0.7	-0.4	0.3	0.2	-0.6	0.8
Patch foraging total patch changes 0 sec	1.4	2.2	4.6	-1.1	-1.1	1.9	-2.1	-0.6
Patch foraging total patch changes 12 sec	4.4	5.7	8.9	-2.1	-3.0	2.2	-1.6	-2.8
Patch foraging total patch changes 18 sec	0.5	0.6	0.8	-0.4	-0.8	0.9	-0.8	-0.9
Patch foraging total patch changes 24 sec	1.4	1.8	2.3	-1.3	-1.5	1.4	-1.0	-1.3
Patch foraging total patch changes 6 sec	2.0	2.9	3.9	-1.5	-2.0	1.9	-1.8	-1.2
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.3	-0.4	0.1	-0.4	-0.6
Patch foraging water rate 0 sec	0.1	0.1	0.5	-0.3	-0.2	0.7	-0.3	0.1
Patch foraging water rate 12 sec	0.1	0.2	0.5	-0.2	0.7	0.4	0.3	0.1
Patch foraging water rate 18 sec	0.8	1.1	2.0	-0.9	-1.4	0.4	0.7	-1.4
Patch foraging water rate 24 sec	0.4	0.6	1.4	-0.8	-1.2	0.7	-0.4	-0.8
Patch foraging water rate 6 sec	1.3	1.9	2.9	-1.6	-1.7	1.3	-0.8	-1.3
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	2.9	-1.1	0.9	1.5	-1.7	1.3
Distance traveled before self-admin	0.4	0.4	1.3	0.1	0.9	-0.1	1.1	-0.4
Distance traveled after self-admin	1.1	1.2	1.8	1.1	1.1	-1.2	1.3	0.7
Extensor digitorum longus weight	6.8	26.7	34.9	5.7	5.9	-5.6	3.6	4.7
Bone: elastic displacement	0.1	0.1	0.2	0.4	0.2	0.2	-0.4	0.3
Bone: elastic work	0.2	0.2	0.4	-0.3	-0.5	0.4	0.5	-0.6
Bone: endosteal estimation	2.3	5.0	8.5	2.7	1.4	-2.7	2.9	-0.1
Bone: endosteal perimeter	1.1	2.4	4.4	2.1	1.3	-1.7	1.6	0.3
Epididymis fat weight	0.1	0.2	0.5	0.5	-0.1	-0.1	0.7	-0.7
Delta time in closed arm before/after self-admin	2.5	2.4	3.5	1.7	1.1	-1.7	1.9	1.3
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.2	0.6	-0.0	0.3	0.5
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	-0.2	0.4	0.7	0.0	-0.4
Delay discount exponential model param	0.2	0.2	0.4	0.6	0.5	-0.1	0.4	-0.1
Extinction: sum of active levers before priming	1.5	1.5	3.1	1.5	0.7	-1.2	1.8	0.3
Active lever presses in extinction session 6	3.3	3.2	8.6	-1.1	-1.7	1.2	1.4	-2.9
Bone: final force	1.0	1.6	4.1	-0.4	-1.4	0.3	1.2	-2.0
Bone: final moment	0.8	1.4	3.5	-0.2	-1.2	0.1	1.3	-1.9
Food consumed during 24 hour testing period	0.7	0.8	1.0	1.0	0.9	-1.0	0.9	0.6
Glucose	0.1	0.2	0.3	-0.1	-0.4	-0.2	0.6	-0.5
Heart weight	2.9	4.0	5.5	2.3	1.7	-2.3	1.6	1.9
Delay discount hyperbolic model param	0.2	0.2	0.5	0.7	0.7	-0.3	0.4	0.0
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-1.1	-0.7	0.8	-0.7	-0.3
Intermittent access intake escalation	0.6	0.6	1.3	-1.1	-0.8	0.9	-0.6	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.2	-0.4	0.1	0.0	-0.2
Intermitt. access day 1 inactive lever presses	2.9	3.1	6.0	-2.1	-2.4	1.6	-0.8	-1.3
Intermitt. access day 15 inactive lever presses	4.4	4.8	6.4	-2.5	-2.5	2.3	-2.2	-1.2
Intermitt. access escalation Index	1.4	1.2	2.9	0.9	0.9	-1.1	1.7	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.2	0.2	0.1	-0.4
Intermittent access day 15 total infusions	0.6	0.6	1.8	-1.4	-0.5	0.9	-0.6	-0.2
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.4	-1.2	-0.6	0.7	-0.5	-0.5
Intermittent access total infusions	0.1	0.2	0.6	-0.8	0.1	0.4	-0.1	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.0	-0.0	0.3	-0.6	-0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.1	-0.3	-0.0	-0.6	-0.3
Intermittent access total locomotion	0.4	0.5	1.3	-0.6	-0.3	0.7	-1.1	-0.2
Intermittent access standard deviation	2.1	2.2	3.4	-1.8	-1.1	1.8	-1.7	-0.5
Left kidney weight	0.3	0.8	1.6	0.5	1.1	-0.6	0.5	1.3
Right kidney weight	0.1	0.3	1.2	-0.1	-0.0	-0.5	1.1	-0.4
Cocaine induced anxiety	1.8	2.1	6.0	1.2	0.5	-1.7	2.4	-0.1
Post-drug Anxiety	0.3	0.4	1.3	0.2	0.4	-0.5	1.2	-0.0
Baseline Anxiety	1.2	1.3	3.4	-1.0	-0.2	1.4	-1.8	0.4
Tail length	0.1	0.3	0.5	0.2	0.7	-0.7	-0.1	0.7
Length with tail	1.3	4.6	6.5	2.2	2.6	-2.2	2.1	1.7
Length without tail	2.1	4.7	9.6	2.3	2.2	-1.9	3.1	0.6
Times rat made contact with spout	0.5	0.6	1.7	-0.3	-1.3	0.5	-0.4	-0.9
Lifetime Intake	0.3	0.3	1.1	-1.0	-0.1	0.6	-0.2	-0.2
Liver weight, left	0.0	0.0	0.1	-0.2	-0.1	0.0	0.1	-0.4
Liver weight, right	0.8	1.3	3.5	-1.9	-1.1	0.6	-0.1	-1.2
Locomotor activity	0.8	1.3	3.5	-0.5	-1.3	0.5	0.8	-1.9
Locomotor testing distance	1.6	2.7	3.7	-1.6	-1.8	1.9	-0.9	-1.8
Locomotor testing rearing	5.4	8.4	11.2	-3.3	-2.8	3.3	-3.0	-1.7
Locomotion in novel chamber	3.3	4.0	7.2	-2.7	-1.8	2.3	-1.2	-1.8
Locomotion in novel chamber post-restriction	0.8	1.0	2.7	-0.3	-0.9	0.6	0.8	-1.6
Fecal boli incidents, locomotor time 1	0.7	0.7	1.3	1.1	0.6	-1.1	0.8	0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.2	-0.0
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.3	-0.5	0.0	1.1	-1.5	0.4
Bouts of movement, locomotor time 1	0.3	0.3	1.2	0.4	0.2	-0.4	1.1	-0.0
Total resting periods, locomotor time 1	0.9	1.0	2.6	1.0	0.4	-1.1	1.6	0.1
Rest time, locomotor task time 1	0.6	0.7	1.1	0.5	-1.1	-0.8	0.8	-0.8
Distance moved, locomotor task time 1	0.3	0.3	0.5	-0.7	0.5	0.6	-0.7	0.3
Vertical activity count, locomotor time 1	0.2	0.2	0.8	0.2	0.9	-0.3	-0.3	0.4
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.8	-0.8	-0.1	1.3	-0.8	-1.3
Bouts of movement, locomotor time 2	0.9	1.0	1.8	-1.0	-0.7	1.3	-1.2	-0.5
Total resting periods, locomotor time 2	0.8	0.9	1.6	-0.9	-0.6	1.3	-1.2	-0.2
Rest time, locomotor task time 2	0.7	0.8	1.3	1.0	0.5	-1.2	1.1	0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	0.0	-0.3	0.2	0.0
Vertical activity count, locomotor time 2	0.4	0.4	1.2	0.4	0.5	-1.1	-0.0	0.6
Light reinforcement 1	2.6	4.7	8.2	-2.3	-2.9	1.9	-1.6	-2.0
Light reinforcement 2	1.0	1.3	3.9	-0.6	-2.0	0.1	0.4	-1.4
Bone: marrow area	2.2	4.7	8.1	2.6	1.3	-2.6	2.8	-0.1
Bone: maximum diameter	0.1	0.2	0.6	-0.0	-0.3	0.3	0.3	-0.8
Bone: maximum force	0.5	0.8	2.3	0.4	-0.4	-0.5	1.5	-1.0
Bone: maximum moment	0.5	0.8	2.5	0.6	-0.3	-0.6	1.6	-0.8
Mean time between licks in bursts	1.3	1.8	4.1	2.0	1.2	-1.4	1.2	0.4
Mean num. licks in bursts	0.3	0.4	1.1	-0.5	-0.0	0.3	-1.1	0.7
Cd content in liver	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.4	0.0
Co content in liver	0.7	0.8	2.2	0.5	1.1	-0.5	-0.2	1.5
Cu content in liver	0.4	0.4	0.7	-0.5	0.2	0.7	-0.8	0.8
Fe content in liver	0.8	0.9	2.2	0.8	0.6	-1.2	1.5	0.1
K content in liver	1.7	1.7	3.3	-1.8	-1.3	1.3	-0.3	-1.3
Mg content in liver	2.1	2.2	4.4	-2.1	-0.5	1.9	-1.6	0.1
Mn content in liver	2.8	3.2	5.0	-2.2	-1.6	2.2	-1.7	-1.0
Na content in liver	1.0	1.1	2.9	-0.5	-0.9	-0.2	1.2	-1.7
Rb content in liver	1.1	1.4	2.2	-1.3	-1.1	1.5	-1.3	-0.5
Se content in liver	4.9	6.0	9.9	-3.2	-2.3	2.7	-2.2	-1.5
Sr content in liver	0.4	0.4	1.0	-0.5	0.0	0.7	-1.0	0.4
Zn content in liver	2.3	2.5	3.2	-1.8	-1.7	1.7	-1.5	-1.1
Bone: minimum diameter	0.4	0.8	2.0	1.0	0.6	-0.8	1.4	-0.0
Time in familiar zone, hab. session 1	1.4	1.4	2.7	-0.0	-1.3	-0.7	1.3	-1.6
Time in novel zone, hab. session 1	2.0	1.9	4.8	-0.8	0.0	1.7	-2.2	1.1
Total zone transitions, hab. session 1	1.1	1.5	2.2	1.3	1.3	-1.2	0.8	1.5
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.3	0.0	0.3	-0.2	0.6
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.0	0.6	-0.2	0.3	0.7
Time in familiar zone, hab. session 2	0.5	0.6	1.1	-0.9	-1.0	0.1	0.3	-0.9
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.2	-0.2	1.0	-1.1	0.0
Total zone transitions, hab. session 2	0.9	1.1	2.0	1.4	0.7	-1.4	0.8	0.7
Total locomotion distance, hab. session 2	0.4	0.5	1.0	0.9	0.1	-1.0	0.8	0.1
Locomotion velocity, hab. session 2	0.5	0.7	1.4	1.1	0.4	-1.2	0.9	0.3
Novel to familiar place preference ratio	0.6	0.6	1.9	0.2	1.4	-0.3	-0.0	1.1
Novelty place preference	0.7	0.7	2.0	0.1	1.4	-0.1	-0.3	1.3
Time in novel zone, NPP test	0.4	0.4	1.0	-0.3	1.0	0.2	-0.5	0.9
Total zone transitions, NPP test	1.2	1.7	2.8	1.6	0.2	-1.7	1.7	-0.3
Total locomotion distance, NPP test	0.4	0.6	1.0	0.8	-0.6	-0.8	1.0	-0.6
Locomotion velocity, NPP test	0.6	0.9	1.6	1.3	0.1	-1.3	1.2	0.0
Intraocular pressure	3.3	4.5	6.4	2.4	2.4	-2.5	0.8	2.0
Delta distance traveled before/after self-admin	0.9	0.9	1.6	1.0	0.7	-1.3	0.3	1.3
Delta ambulatory time before/after self-admin	0.8	0.8	2.3	1.0	-0.1	-1.5	0.6	0.6
Parametrial fat weight	1.4	2.7	5.1	-1.6	-2.0	1.4	0.2	-2.3
Pavlov. Cond. lever latency	2.2	2.8	5.8	1.1	2.4	-1.1	0.2	2.4
Pavlov. Cond. magazine entry latency	6.9	8.9	13.9	-3.1	-3.7	2.9	-1.7	-3.2
Pavlov. Cond. change in total contacts	7.3	7.8	10.5	-3.2	-2.9	3.2	-2.7	-1.6
Pavlov. Cond. index score	5.4	6.9	12.3	-2.4	-3.5	2.3	-1.2	-3.1
Pavlov. Cond. latency score	4.1	5.2	10.0	-1.9	-3.2	1.8	-0.8	-2.9
Pavlov. Cond. lever contacts	1.8	2.1	4.8	-0.7	-2.1	0.9	-0.1	-2.2
Pavlov. Cond. magazine entry number	8.2	10.3	15.6	3.4	4.0	-3.2	2.2	3.0
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.6	0.9	1.6	-0.8	0.0	1.6
Pavlov. Cond. lever-magazine prob. diff.	6.0	7.4	12.5	-2.5	-3.5	2.6	-1.5	-3.0
Pavlov. Cond. response bias	6.6	8.0	12.1	-2.9	-3.5	2.9	-1.9	-2.7
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.5	0.7	-0.8	0.1	0.8
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	0.4	0.4	-0.4	0.7	0.0
Pavlov. Cond. change in total contacts	0.5	0.6	1.2	-0.7	-0.7	1.1	-0.9	-0.4
Pavlov. Cond. index score	0.1	0.1	0.4	-0.1	-0.4	0.2	0.2	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	0.1	-0.2	0.0	0.3	-0.5
Pavlov. Cond. lever contacts	0.6	0.8	1.7	-0.6	-1.1	0.8	0.0	-1.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	0.2	-0.0	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	1.1	1.5	3.5	0.7	1.9	-0.3	-0.4	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.0	-0.3	0.1	0.3	-0.5
Pavlov. Cond. response bias	0.8	1.1	1.9	-0.9	-1.3	1.0	-0.1	-1.4
Time in closed arm before self-admin	1.1	1.3	3.0	-1.2	-1.2	0.6	-1.7	-0.1
Time in closed arm after self-admin	0.5	0.5	2.1	0.0	0.6	-0.3	-0.3	1.4
Time in open arm before self-admin	1.1	1.2	2.3	1.1	1.5	-0.7	1.3	0.3
Time in open arm after self-admin	0.6	0.6	1.6	0.8	1.3	-0.5	0.7	0.5
Bone: periosteal estimation	0.5	1.0	2.6	1.0	0.2	-0.9	1.6	-0.7
Bone: periosteal perimeter	0.9	1.4	3.0	1.5	0.6	-1.2	1.7	-0.3
Bone: post-yield work	1.0	1.4	2.3	1.5	0.9	-1.3	1.3	0.7
Progressive ratio test 1 active lever presses	0.4	0.4	0.8	-0.9	-0.4	0.6	-0.6	-0.3
Progressive ratio test 1 breakpoint	0.3	0.3	0.8	-0.9	-0.4	0.5	-0.5	-0.2
Progressive ratio test 1 inactive lever presses	1.9	2.1	3.3	-1.8	-1.5	1.6	-1.4	-0.6
Progressive ratio test 2 active lever presses	0.8	0.8	1.7	-1.1	-0.3	1.0	-1.3	-0.4
Progressive ratio test 2 breakpoint	0.6	0.6	1.3	-1.0	-0.2	0.9	-1.1	-0.3
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.8	-0.8	-0.4	0.7	-0.9	-0.3
Incentive Sensitization - Responses	0.6	0.7	2.1	-0.4	-0.2	0.8	-1.5	-0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.7	-0.4	-0.3	0.7	-1.3	-0.7
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	-0.9	-1.1	0.6	0.0	-1.0
Progressive ratio	0.2	0.3	1.0	-0.2	-0.5	-0.1	0.1	-1.0
Food seeking constrained by brief footshock	0.4	0.5	1.3	-0.4	-1.0	-0.2	-0.1	-1.1
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.0	0.2	-0.0	-0.1	0.4
Retroperitoneal fat weight	0.1	0.2	0.5	0.2	-0.4	-0.7	0.6	-0.3
Reaction time number correct	0.8	1.2	1.8	1.2	1.4	-0.9	1.4	0.3
Reaction time mean minus median	0.4	0.5	1.0	1.0	0.6	-0.7	-0.5	0.7
Reaction time mean minus median AUC	0.1	0.2	0.4	0.6	0.2	-0.2	-0.6	0.4
Reaction time num false alarms	0.6	0.8	2.3	-0.1	-1.1	-0.1	0.8	-1.5
Reaction time num false alarms AUC	0.6	0.8	2.5	0.2	-1.0	-0.1	0.8	-1.6
Reaction time trials correct on left	0.8	1.2	1.8	1.2	1.4	-0.9	1.4	0.3
Reaction time trials on left	0.8	1.1	1.8	1.2	1.3	-0.8	1.3	0.3
Reaction time mean	0.6	0.8	2.4	-0.9	-0.1	0.7	-1.6	0.4
Reaction time mean AUC	0.6	0.8	2.2	-1.0	-0.2	0.7	-1.5	0.4
Median of all reaction times	1.2	1.7	3.3	-1.7	-0.7	1.3	-1.8	-0.1
Reaction time omissions	0.8	1.0	2.1	-1.0	-1.4	0.7	-0.8	-1.0
Reaction time false alarm rate	0.7	1.0	2.4	-0.5	-1.6	0.4	0.1	-1.5
Reaction time premature initiation rate	0.6	0.9	2.5	-1.6	-0.6	0.7	0.5	-0.8
Reaction time premature initiations	0.3	0.4	1.6	-0.6	0.3	0.0	1.3	-0.3
Std. dev. reaction times	0.1	0.2	0.5	0.3	0.2	-0.1	-0.7	0.4
Reaction time trials completed	0.8	1.1	1.8	1.2	1.3	-0.8	1.3	0.3
Reaction time trials AUC	0.7	1.0	1.8	1.1	1.4	-0.7	1.1	0.3
Run reversals in cocaine runway, females	2.3	2.3	5.5	0.3	2.3	-0.6	0.0	2.3
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.7	0.2	0.5	-0.7	-0.0
Latency to leave start box in cocaine runway	1.1	1.2	2.3	1.0	1.5	-0.7	0.8	1.2
Latency to leave start box in cocaine runway, F	1.4	1.6	3.4	0.9	1.9	-0.7	1.5	1.0
Latency to leave start box in cocaine runway, M	0.9	0.8	2.2	-0.5	-0.8	1.0	-1.5	0.3
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.6	-0.2	-0.3	0.7	-0.6
Total sessions with >9 infusions	1.0	1.1	1.9	-1.3	-1.0	1.0	-1.4	-0.0
Short access day 1 total inactive lever presses	1.8	2.0	3.0	-1.7	-1.7	1.4	-1.4	-0.7
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.2	-0.5	-0.0	0.4	-0.0
Short access day 1 total infusions	1.1	1.2	3.0	-1.7	-0.9	1.2	-0.9	-0.2
Short access day 10 total infusions	0.2	0.3	0.5	-0.7	-0.5	0.3	-0.0	-0.7
Short access total infusions	0.6	0.6	2.0	-1.4	-0.3	0.9	-0.5	-0.1
Short access day 1 locomotion	3.9	4.2	6.6	-2.2	-2.6	2.1	-1.9	-1.4
Short access day 10 total locomotion	0.7	0.7	1.3	-0.5	-0.8	0.7	-1.2	-1.0
Short access total locomotion	0.6	0.6	1.8	-0.6	-0.5	0.8	-1.4	0.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	0.4	0.1	-0.4	0.2
Compulsive drug intake	1.3	1.3	3.3	0.5	1.3	-0.0	-1.2	1.8
One hour access (shock baseline)	0.4	0.4	1.0	-0.8	-0.6	0.3	0.3	-1.0
Social response proportion	0.2	0.2	0.4	0.5	0.2	-0.7	0.4	0.4
Social responses	0.3	0.4	0.9	0.1	-0.9	-0.3	0.3	-0.8
Social time	0.7	1.0	1.6	1.1	-0.1	-1.1	1.3	-0.9
Soleus weight	0.6	1.9	3.7	0.9	-0.7	-1.4	1.9	-1.5
Bone: stiffness	0.3	0.5	1.5	-0.1	-0.4	-0.4	1.2	-0.8
Tibialis anterior weight	1.3	4.5	7.5	2.1	1.8	-2.7	2.5	0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.8	-0.1	-0.2	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.4	-0.3	-0.2	-0.2	-0.6
Time to tail flick, test, before self-admin	1.2	1.2	1.8	1.3	1.1	-1.4	0.8	0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.5	0.7	-0.6	-0.2	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	2.4	-0.0	-0.8	-0.0	0.7	-1.5
Delta time to tail flick, test, before/after SA	1.2	1.1	1.8	-0.8	-1.4	1.0	-0.9	-0.9
Tibia length	1.8	5.1	9.6	2.4	1.5	-2.8	3.1	0.4
Ambulatory time before self-admin	0.2	0.2	1.0	0.2	1.0	0.0	0.4	0.2
Ambulatory time after self-admin	1.8	2.0	4.0	1.5	0.8	-2.0	1.6	0.7
Bone: tissue strength	0.9	0.9	2.0	1.4	0.8	-0.9	0.7	0.7
Total heroin consumption	2.0	2.4	6.8	-0.9	-1.6	1.2	0.5	-2.6
Bone: trabecular number	4.1	6.3	10.5	-2.6	-3.2	2.1	-1.0	-3.0
Bone: trabecular spacing	2.0	2.6	4.1	1.9	1.3	-2.0	1.9	0.5
Bone: trabecular thickness	0.1	0.2	0.5	-0.1	-0.7	0.3	-0.2	-0.5
Bone: trabecular tissue density	0.8	1.2	2.5	-0.5	0.8	0.8	-1.6	1.4
Water consumed over 24 hours	0.1	0.2	0.4	0.6	0.0	-0.4	0.5	-0.0
Number of responses in last shaping day	1.1	1.1	2.2	-1.2	-0.6	1.3	-1.5	0.3