Hub : Genes

Gfra2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Gfra2	0.04	0.03	1.8e-03	0.02	0	0	0.01	1.9e-03	1.1e-01	1.1e-01	3.5e-02
2	Brain	gene expression	Gfra2	0.06	0.05	4.0e-04	0.03	0.03	0.03	0.03	5.5e-04	4.6e-04	1.0e-03	1.5e-03
3	PL	gene expression	Gfra2	0.09	0.06	1.9e-08	0.07	0.07	0.07	0.07	3.9e-08	4.1e-08	3.1e-08	6.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.9	1.5	2.6	1.3	-0.3	1.6
Area under the delay curve	0.0	0.0	0.0	0.0	-0.2	0.1
BMI with tail	0.9	3.0	4.4	-2.1	1.4	-1.7
BMI without tail	0.3	0.7	1.4	0.1	1.2	0.8
Body weight	0.2	0.8	1.6	-0.6	-0.6	-1.3
Weight adjusted by age	0.6	0.7	1.2	-0.4	-0.8	-1.1
Bone surface	0.7	1.3	1.8	1.3	-0.8	1.2
Bone volume	0.8	1.3	1.8	1.3	-0.8	1.3
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.2	0.0	-0.2
Number of licking bursts	0.1	0.1	0.2	-0.3	0.4	-0.2
Context. condit. distance diff. score	4.0	4.8	11.1	-1.8	3.3	0.1
Locomotion velocity, session 1	0.1	0.1	0.2	0.0	-0.5	-0.3
Locomotion distance, session 1	1.6	2.1	3.4	1.6	-1.8	0.6
Locomotion velocity, session 2	0.7	0.8	1.2	1.0	-1.1	0.5
Locomotion distance, session 2	3.2	4.5	7.6	2.3	-2.8	0.9
Locomotion velocity, session 3	1.9	2.2	3.0	-1.7	1.5	-1.1
Locomotion distance, session 3	0.6	0.7	1.5	-0.8	1.2	-0.1
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.5	-0.3	-0.8
Stereotopy head waving duration, day 3	1.0	1.3	2.4	-0.9	-0.8	-1.5
Locomotion velocity, session 7	4.9	5.4	13.1	-1.2	3.6	1.3
Locomotion distance, session 7	2.7	3.4	8.0	-0.6	2.8	1.4
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	-0.4	-1.0	-1.1
Stereotopy head waving duration, day 7	1.0	1.3	2.5	-0.9	-0.7	-1.6
Locomotion velocity, session 8	0.6	0.7	1.4	-0.8	1.2	-0.2
Locomotion distance, session 8	0.3	0.4	0.7	0.4	0.4	0.9
Degree of sensitization distance	2.0	2.0	3.0	0.3	1.7	1.7
Degree of sensitization stereotypy	0.5	0.5	1.1	-0.6	-0.4	-1.0
Conditioned locomotion	0.3	0.4	0.8	-0.5	0.9	-0.1
Cocaine response after cond. corrected	2.6	2.9	4.1	-1.9	2.0	-1.1
Cocaine response after cond. not corrected	1.2	1.3	1.8	-1.2	1.3	-0.8
Cocaine response before conditioning	1.9	2.3	3.4	1.7	-1.8	0.9
Saline control response	0.7	1.0	1.3	1.1	-1.0	0.7
Bone: connectivity density	1.3	2.1	4.2	1.5	0.2	2.1
Bone: cortical apparent density	2.5	3.2	6.2	-1.8	2.5	-0.5
Bone: cortical area	0.1	0.2	0.3	0.5	-0.5	0.2
Bone: cortical porosity	1.4	1.5	3.7	0.5	-1.9	-0.7
Bone: cortical porosity	1.4	1.6	3.8	0.9	-1.9	-0.3
Bone: cortical thickness	0.0	0.0	0.1	0.2	0.0	0.2
Bone: cortical thickness	0.7	0.9	1.8	-0.9	1.4	-0.1
Bone: cortical tissue density	2.6	3.5	6.6	-1.9	2.6	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.8	0.2	-0.9	-0.4
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.4	-1.4	0.3	-1.6
Condit. Reinf. active responses	1.2	1.4	2.5	1.3	-1.6	0.4
Condit. Reinf. inactive responses	5.6	6.6	9.6	3.1	-2.1	2.4
Incentive salience index mean	1.0	1.3	3.1	0.7	-1.8	-0.4
Condit. Reinf. lever presses	1.8	2.4	5.0	1.4	-2.2	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.5	0.0	0.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	-0.7	0.7	-0.5
Condit. Reinf. active responses	0.6	0.8	1.4	1.0	-0.2	1.2
Condit. Reinf. inactive responses	1.9	2.3	3.6	1.7	-0.6	1.9
Condit. Reinf. lever presses	1.4	1.9	2.8	1.5	-1.7	0.8
Condit. Reinf. lever reinforcers received	0.5	0.6	1.0	0.9	-0.3	1.0
Conditioned reinforcement - actives	1.3	1.3	1.9	0.2	1.4	1.3
Conditioned reinforcement - inactives	2.1	2.4	4.0	1.7	-0.5	2.0
Conditioned locomotion	0.4	0.5	1.0	0.5	0.4	1.0
Patch foraging indifference point 0 sec	5.9	9.5	12.6	3.6	-3.0	2.6
Patch foraging indifference point AUC	1.1	1.3	1.7	-1.3	1.1	-1.0
Delay disc. indifference point, 0s delay	1.4	1.5	2.0	1.4	-1.2	1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.2	0.2	0.5
Delay disc. indifference point, 2s delay	0.6	0.7	1.2	-0.2	-1.1	-0.9
Delay disc. indifference point, 24s delay	0.5	0.4	0.6	-0.8	0.7	-0.5
Delay disc. indifference point, 4s delay	1.0	1.1	1.7	-1.2	0.2	-1.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	-0.2	0.4
Indifference point function ln k	0.9	1.2	2.2	1.1	-1.5	0.4
Indifference point function log k	0.9	1.2	2.2	1.1	-1.5	0.4
Patch foraging total patch changes 0 sec	5.5	8.8	11.8	3.4	-3.0	2.4
Patch foraging total patch changes 12 sec	2.0	2.7	3.6	1.9	-1.5	1.4
Patch foraging total patch changes 18 sec	1.6	2.1	3.2	1.7	-0.4	1.8
Patch foraging total patch changes 24 sec	1.7	2.1	3.7	1.5	-1.9	0.6
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	0.9	-0.4	0.7
Patch foraging time to switch 0 sec	0.4	0.5	1.1	0.7	0.3	1.0
Patch foraging water rate 0 sec	0.3	0.4	1.0	0.1	-1.0	-0.5
Patch foraging water rate 12 sec	0.3	0.5	0.9	0.1	-0.9	-0.8
Patch foraging water rate 18 sec	2.0	2.7	4.9	-1.8	0.2	-2.2
Patch foraging water rate 24 sec	0.6	0.9	1.1	-1.0	1.0	-0.8
Patch foraging water rate 6 sec	1.0	1.4	2.4	-0.2	-1.6	-1.3
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	1.9	1.3	-0.6	1.4
Distance traveled before self-admin	1.1	1.2	3.0	0.5	-1.7	-0.6
Distance traveled after self-admin	1.8	1.9	2.9	-1.6	0.5	-1.7
Extensor digitorum longus weight	6.2	24.3	49.7	-4.8	-0.6	-7.0
Bone: elastic displacement	1.7	1.9	2.8	1.7	-1.2	1.2
Bone: elastic work	3.1	4.0	5.2	2.3	-2.3	1.3
Bone: endosteal estimation	0.1	0.3	0.6	0.2	-0.8	-0.3
Bone: endosteal perimeter	0.3	0.7	1.6	0.6	-1.3	-0.1
Epididymis fat weight	0.9	2.2	4.4	1.4	0.4	2.1
Delta time in closed arm before/after self-admin	2.1	2.0	3.2	1.4	-0.9	1.8
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.2	0.6	-0.0
Diff in mean of infusions in LGA sessions	1.6	1.8	3.5	-1.4	0.2	-1.9
Delay discount exponential model param	0.0	0.1	0.1	0.3	0.1	0.3
Extinction: sum of active levers before priming	0.9	0.9	1.8	0.7	0.7	1.3
Active lever presses in extinction session 6	0.3	0.3	0.7	-0.3	0.8	0.4
Bone: final force	0.0	0.1	0.1	-0.1	-0.3	-0.4
Bone: final moment	0.2	0.3	0.6	0.3	-0.8	-0.2
Food consumed during 24 hour testing period	1.1	1.3	1.7	1.3	-1.2	0.9
Glucose	0.7	1.1	2.1	-1.1	1.5	-0.2
Heart weight	0.3	0.4	0.6	0.8	-0.8	0.3
Delay discount hyperbolic model param	0.1	0.2	0.2	0.3	0.3	0.5
Intermittent access intake day 1-15 change	1.1	1.1	2.2	1.1	0.0	1.5
Intermittent access intake escalation	0.6	0.6	1.3	0.7	0.2	1.2
Intermittent access intake escalation 2	0.2	0.2	0.4	0.3	0.2	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.1	0.1	0.3
Intermitt. access day 15 inactive lever presses	0.4	0.5	0.8	0.7	-0.9	0.3
Intermitt. access escalation Index	0.5	0.4	0.6	-0.8	0.4	-0.7
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	0.2	0.1
Intermittent access day 15 total infusions	0.4	0.4	0.9	0.5	0.4	1.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.2	0.7	0.3
Intermittent access total infusions	0.3	0.3	0.7	-0.0	0.8	0.5
Intermittent access day 1 locomotion	0.4	0.5	0.6	0.8	-0.5	0.7
Intermittent access day 15 total locomotion	0.6	0.6	1.3	0.5	0.5	1.1
Intermittent access total locomotion	0.3	0.3	0.5	0.6	-0.1	0.7
Intermittent access standard deviation	0.9	0.9	1.6	1.0	-0.3	1.3
Left kidney weight	0.2	0.6	1.3	0.2	-1.1	-0.7
Right kidney weight	0.9	2.6	3.4	1.8	-1.9	1.0
Cocaine induced anxiety	2.4	2.8	6.0	1.5	-2.4	0.3
Post-drug Anxiety	1.4	1.6	2.1	1.4	-1.2	1.1
Baseline Anxiety	0.4	0.4	0.7	0.1	0.8	0.7
Tail length	1.2	3.8	5.7	2.4	-1.4	1.9
Length with tail	0.5	1.8	3.9	1.2	-2.0	0.0
Length without tail	1.5	3.4	6.4	-1.4	-1.3	-2.5
Times rat made contact with spout	0.2	0.2	0.4	0.3	0.5	0.6
Lifetime Intake	0.2	0.2	0.5	0.1	0.7	0.5
Liver weight, left	1.0	1.5	3.4	-1.1	-0.3	-1.8
Liver weight, right	0.5	0.8	1.4	-0.9	0.2	-1.2
Locomotor activity	4.3	6.8	16.7	1.9	-4.1	-0.4
Locomotor testing distance	5.1	8.5	15.4	3.0	-3.9	1.1
Locomotor testing rearing	8.3	12.8	20.7	3.8	-4.6	1.8
Locomotion in novel chamber	0.6	0.8	0.9	1.0	-0.8	0.9
Locomotion in novel chamber post-restriction	0.3	0.4	0.7	-0.7	0.1	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.5	-0.1	-0.7	-0.7
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	-0.8	0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.6	1.0	-0.4	1.3
Bouts of movement, locomotor time 1	3.4	3.7	6.3	-2.1	0.4	-2.5
Total resting periods, locomotor time 1	4.3	4.7	7.0	-2.5	0.9	-2.6
Rest time, locomotor task time 1	2.4	2.7	4.4	-1.9	0.4	-2.1
Distance moved, locomotor task time 1	1.8	1.9	3.8	1.4	0.1	2.0
Vertical activity count, locomotor time 1	2.6	2.7	3.7	1.9	-1.5	1.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.3	-0.2	-0.6
Bouts of movement, locomotor time 2	3.2	3.4	4.9	-2.1	0.9	-2.2
Total resting periods, locomotor time 2	4.1	4.3	6.0	-2.4	1.1	-2.4
Rest time, locomotor task time 2	2.7	3.1	4.3	-2.1	1.5	-1.7
Distance moved, locomotor task time 2	3.9	4.5	6.2	2.5	-1.4	2.3
Vertical activity count, locomotor time 2	2.7	3.0	4.0	2.0	-2.0	1.1
Light reinforcement 1	1.4	2.5	4.9	0.9	1.4	2.2
Light reinforcement 2	2.0	2.7	6.9	-0.9	2.6	0.7
Bone: marrow area	0.1	0.3	0.7	0.3	-0.8	-0.2
Bone: maximum diameter	0.2	0.3	0.7	-0.6	0.0	-0.8
Bone: maximum force	0.2	0.4	0.9	0.2	-0.9	-0.4
Bone: maximum moment	0.5	0.9	2.1	0.8	-1.4	-0.1
Mean time between licks in bursts	1.8	2.6	4.0	2.0	-0.5	1.9
Mean num. licks in bursts	0.2	0.2	0.4	0.4	0.0	0.7
Cd content in liver	0.1	0.1	0.3	0.2	0.3	0.5
Co content in liver	4.2	4.9	7.0	-2.6	1.3	-2.5
Cu content in liver	0.4	0.5	0.8	-0.9	0.3	-0.9
Fe content in liver	1.1	1.4	2.6	1.2	-0.0	1.6
K content in liver	0.3	0.3	0.4	0.2	0.6	0.6
Mg content in liver	0.5	0.5	0.9	0.3	0.8	1.0
Mn content in liver	1.2	1.3	2.5	1.2	-0.1	1.6
Na content in liver	3.9	4.2	9.5	1.7	-3.1	0.0
Rb content in liver	0.8	1.0	2.5	-0.8	1.6	0.1
Se content in liver	5.2	6.3	8.2	2.9	-2.8	1.8
Sr content in liver	0.5	0.4	0.6	0.8	-0.3	0.8
Zn content in liver	1.7	1.9	4.7	0.9	-2.2	-0.5
Bone: minimum diameter	0.6	1.1	2.5	0.9	-1.6	-0.1
Time in familiar zone, hab. session 1	0.3	0.2	0.3	-0.6	0.6	-0.3
Time in novel zone, hab. session 1	1.4	1.3	1.9	-1.4	0.7	-1.3
Total zone transitions, hab. session 1	0.5	0.8	1.8	0.7	-1.3	-0.1
Total locomotion distance, hab. session 1	1.3	1.9	3.1	1.5	-1.8	0.6
Locomotion velocity, hab. session 1	3.0	4.2	6.2	2.3	-2.5	1.1
Time in familiar zone, hab. session 2	4.3	4.4	5.9	-2.4	1.8	-2.0
Time in novel zone, hab. session 2	1.7	1.7	2.3	1.5	-1.2	1.2
Total zone transitions, hab. session 2	1.6	2.0	5.1	0.7	-2.3	-0.8
Total locomotion distance, hab. session 2	0.9	1.2	2.7	0.9	-1.6	-0.1
Locomotion velocity, hab. session 2	1.3	1.7	4.2	0.9	-2.0	-0.3
Novel to familiar place preference ratio	1.8	1.9	2.5	1.6	-0.8	1.5
Novelty place preference	1.5	1.5	2.1	1.4	-0.8	1.4
Time in novel zone, NPP test	0.9	1.0	1.3	1.1	-0.7	1.0
Total zone transitions, NPP test	1.7	2.4	3.3	1.7	-1.8	1.0
Total locomotion distance, NPP test	4.5	6.2	8.9	3.0	-1.9	2.5
Locomotion velocity, NPP test	4.2	6.0	8.5	2.9	-1.9	2.4
Intraocular pressure	0.4	0.6	1.0	0.9	-0.1	1.0
Delta distance traveled before/after self-admin	5.3	5.7	7.7	-2.8	2.1	-2.2
Delta ambulatory time before/after self-admin	4.1	4.5	6.4	-2.5	1.8	-2.0
Parametrial fat weight	1.5	3.0	6.3	1.5	0.6	2.5
Pavlov. Cond. lever latency	0.6	0.7	1.2	-0.9	1.1	-0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.2	-0.1	0.3
Pavlov. Cond. change in total contacts	0.6	0.7	1.5	0.2	-1.2	-0.7
Pavlov. Cond. index score	0.3	0.3	0.7	0.5	-0.9	-0.0
Pavlov. Cond. latency score	0.3	0.4	0.9	0.7	-0.9	0.1
Pavlov. Cond. lever contacts	0.6	0.7	1.2	1.0	-1.1	0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.3	0.3	0.6
Pavlov. Cond. intertrial magazine entries	1.3	1.5	2.3	1.4	-1.5	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.4	-0.9	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.3	0.1	-0.6	-0.3
Pavlov. Cond. lever latency	1.1	1.5	3.5	-1.0	1.9	0.1
Pavlov. Cond. magazine entry latency	1.1	1.3	1.9	1.2	-1.4	0.7
Pavlov. Cond. change in total contacts	0.8	1.1	2.4	0.1	-1.5	-1.0
Pavlov. Cond. index score	1.3	1.7	4.1	1.0	-2.0	-0.2
Pavlov. Cond. latency score	1.5	1.9	4.3	1.1	-2.1	0.0
Pavlov. Cond. lever contacts	1.7	2.4	5.3	1.3	-2.3	-0.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.1	-0.9	1.0	-0.6
Pavlov. Cond. intertrial magazine entries	3.0	3.9	7.8	2.0	0.1	2.8
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	3.3	0.8	-1.8	-0.3
Pavlov. Cond. response bias	1.8	2.5	5.6	1.3	-2.4	-0.1
Time in closed arm before self-admin	1.6	1.8	3.0	-1.4	0.7	-1.7
Time in closed arm after self-admin	0.3	0.3	0.5	-0.5	-0.2	-0.7
Time in open arm before self-admin	0.1	0.1	0.3	-0.1	-0.5	-0.2
Time in open arm after self-admin	0.1	0.1	0.1	0.3	-0.1	0.2
Bone: periosteal estimation	0.1	0.2	0.6	0.4	-0.8	-0.1
Bone: periosteal perimeter	0.1	0.2	0.5	0.5	-0.7	0.0
Bone: post-yield work	0.3	0.4	0.9	-0.4	1.0	0.1
Progressive ratio test 1 active lever presses	2.2	2.3	3.3	-1.6	1.8	-1.0
Progressive ratio test 1 breakpoint	2.4	2.5	4.1	-1.7	2.0	-0.8
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.3	0.5	0.7	1.2
Progressive ratio test 2 active lever presses	1.6	1.7	3.9	-1.1	2.0	-0.1
Progressive ratio test 2 breakpoint	0.7	0.8	2.0	-0.6	1.4	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	0.4	0.1	0.6
Incentive Sensitization - Responses	0.4	0.4	0.8	0.4	0.5	0.9
Incentive Sensitization - Breakpoint	0.6	0.6	1.2	0.6	0.3	1.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.3	-1.1	1.5	-0.2
Progressive ratio	0.2	0.2	0.3	-0.4	0.5	0.3
Food seeking constrained by brief footshock	6.4	7.9	10.6	-3.3	3.0	-2.1
Seeking ratio, punishment vs. effort	1.4	1.8	2.2	-1.4	1.1	-1.5
Retroperitoneal fat weight	0.2	0.6	1.6	-0.4	1.2	0.4
Reaction time number correct	0.8	1.2	1.6	-1.3	0.8	-1.2
Reaction time mean minus median	0.4	0.6	1.4	0.5	-1.2	-0.2
Reaction time mean minus median AUC	0.1	0.2	0.5	0.2	-0.7	-0.2
Reaction time num false alarms	0.1	0.1	0.3	0.3	-0.5	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.2	0.4	-0.5	0.0
Reaction time trials correct on left	0.8	1.2	1.6	-1.3	0.8	-1.2
Reaction time trials on left	0.7	1.0	1.4	-1.2	0.8	-1.0
Reaction time mean	0.2	0.2	0.6	0.2	-0.8	-0.2
Reaction time mean AUC	0.3	0.4	1.0	0.2	-1.0	-0.4
Median of all reaction times	0.0	0.1	0.2	0.1	-0.4	-0.1
Reaction time omissions	1.2	1.7	3.1	1.4	0.1	1.8
Reaction time false alarm rate	0.2	0.3	0.5	0.7	-0.4	0.5
Reaction time premature initiation rate	2.0	2.6	3.7	-1.9	1.2	-1.7
Reaction time premature initiations	3.2	4.5	6.2	-2.5	1.6	-2.1
Std. dev. reaction times	0.3	0.4	0.9	0.4	-1.0	-0.2
Reaction time trials completed	0.7	1.0	1.4	-1.2	0.8	-1.0
Reaction time trials AUC	0.7	1.0	1.4	-1.2	0.8	-1.0
Run reversals in cocaine runway, females	2.4	2.3	4.6	1.5	-0.1	2.1
Run reversals in cocaine runway, males	1.1	1.0	2.3	-0.9	-0.3	-1.5
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.3	-0.3	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	1.5	-0.5	-0.6	-1.2
Latency to leave start box in cocaine runway, M	1.0	0.9	1.4	1.2	-0.3	1.2
Std. dev. time between licks in bursts	4.7	5.6	8.2	2.9	-2.2	1.9
Total sessions with >9 infusions	0.4	0.4	0.9	-0.5	1.0	-0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.5	0.3	0.3	0.7
Short access day 10 total inactive lever presses	0.2	0.2	0.3	0.1	0.4	0.5
Short access day 1 total infusions	1.5	1.6	2.6	-1.3	1.6	-0.8
Short access day 10 total infusions	0.4	0.4	0.6	0.8	-0.8	0.3
Short access total infusions	0.1	0.1	0.1	0.2	0.4	0.3
Short access day 1 locomotion	0.2	0.2	0.5	0.1	-0.7	-0.3
Short access day 10 total locomotion	0.7	0.8	1.0	1.0	-0.7	1.0
Short access total locomotion	1.1	1.1	1.4	1.2	-0.8	1.1
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.5	-0.1	0.6
Compulsive drug intake	0.8	0.8	1.7	0.8	-1.3	0.2
One hour access (shock baseline)	0.1	0.1	0.2	-0.3	0.5	-0.1
Social response proportion	3.5	3.7	6.4	-2.0	2.5	-0.9
Social responses	0.5	0.6	1.0	0.4	0.8	1.0
Social time	1.2	1.6	2.3	1.5	-1.2	1.1
Soleus weight	0.7	2.0	3.5	-1.6	0.4	-1.9
Bone: stiffness	0.3	0.5	0.9	-0.8	-0.1	-0.9
Tibialis anterior weight	3.6	12.2	25.9	-3.1	-1.1	-5.1
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.0	0.8	-0.1	1.0
Time to tail flick, vehicle, after self-admin	2.8	3.0	4.1	-2.0	1.3	-1.8
Time to tail flick, test, before self-admin	1.4	1.4	1.9	1.4	-1.0	1.2
Time to tail flick, test, after self-admin	1.7	1.7	3.0	0.2	1.7	1.5
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	2.2	-1.5	1.3	-0.9
Delta time to tail flick, test, before/after SA	2.7	2.5	5.9	-1.2	2.4	-0.1
Tibia length	4.0	11.4	16.2	4.0	-3.3	2.7
Ambulatory time before self-admin	0.8	0.8	1.9	0.5	-1.4	-0.4
Ambulatory time after self-admin	2.2	2.4	4.3	-1.7	0.2	-2.1
Bone: tissue strength	0.4	0.4	0.7	0.8	-0.7	0.4
Total heroin consumption	0.2	0.2	0.5	0.1	-0.7	-0.4
Bone: trabecular number	1.4	2.2	4.2	1.6	-0.2	2.0
Bone: trabecular spacing	1.2	1.6	3.0	-1.3	-0.1	-1.7
Bone: trabecular thickness	1.1	1.3	1.9	1.3	-0.5	1.4
Bone: trabecular tissue density	0.5	0.7	1.3	-0.6	-0.7	-1.2
Water consumed over 24 hours	0.5	0.6	1.1	-0.3	-0.8	-1.1
Number of responses in last shaping day	0.2	0.2	0.5	0.5	-0.7	0.1