Hub : Genes

Gclc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Gclc 0.03 0.02 3.7e-03 0 0.02 0.01 0.01 1.6e-01 6.9e-03 1.0e-02 5.2e-02
2 Brain mRNA stability Gclc 0.09 0.05 2.5e-07 0.06 0.07 0.08 0.07 2.1e-06 2.2e-07 1.1e-07 2.7e-07
3 Brain gene expression Gclc 0.03 0.03 8.9e-03 0.02 0.01 0 0.01 1.1e-02 1.3e-02 1.4e-01 1.3e-02
4 PL mRNA stability Gclc 0.03 0.02 2.1e-03 0.01 0.01 0.01 0.01 2.4e-02 2.2e-02 8.2e-03 1.1e-02
5 Eye gene expression Gclc 0.57 0.13 9.9e-06 0.27 0.04 0.05 0.13 5.0e-05 7.3e-02 6.8e-02 4.4e-03
6 Adipose gene expression Gclc 0.1 0.05 2.8e-12 0.07 0.1 0.09 0.1 1.2e-08 2.1e-11 2.6e-10 5.3e-11
7 NAcc mRNA stability Gclc 0.03 0.02 1.8e-03 0.02 0.01 0.01 0.01 5.0e-04 6.9e-03 1.6e-02 2.0e-03
8 pVTA gene expression Gclc 0.04 0.03 3.9e-03 0.04 0.03 0.03 0.03 7.0e-04 2.9e-03 1.3e-03 1.8e-03
9 Brain alternative polyA NM_012815.2 0.04 0.03 5.9e-04 0.04 0.04 0.04 0.04 3.2e-04 1.3e-04 1.0e-04 9.7e-05
10 Liver gene expression Gclc 0.03 0.02 2.1e-03 0.02 0.01 0.02 0.02 1.5e-03 1.0e-02 3.7e-03 6.1e-03
11 Brain alternative polyA XM_039080870.2 0.04 0.03 8.2e-04 0.04 0.04 0.04 0.04 1.9e-04 1.8e-04 1.6e-04 1.6e-04
12 IC gene expression Gclc 0.08 0.04 8.3e-03 -0.01 0 -0.01 -0.01 6.6e-01 2.4e-01 8.7e-01 9.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.61.01.81.30.61.11.31.11.01.01.10.90.1-0.90.9
Area under the delay curve0.60.71.8-0.2-1.1-1.3-0.8-0.6-1.0-0.6-0.6-0.91.20.90.1
BMI with tail6.422.128.13.75.34.65.25.05.24.74.75.1-4.8-4.92.3
BMI without tail2.16.68.62.62.52.62.92.72.82.52.82.7-2.1-2.71.5
Body weight3.214.217.23.93.54.03.94.13.84.04.13.7-3.1-3.63.2
Weight adjusted by age1.72.54.11.61.42.01.71.91.71.81.91.4-0.8-1.31.2
Bone surface3.15.68.42.12.22.72.92.62.62.52.62.3-1.4-2.31.7
Bone volume1.83.34.72.11.32.12.22.01.81.92.01.7-0.6-1.61.7
Breakpoint value in progressive ratio session0.40.41.2-0.30.80.41.10.70.90.60.60.5-0.5-0.6-0.6
Number of licking bursts0.40.72.00.21.00.81.00.50.90.50.61.0-1.4-1.0-0.2
Context. condit. distance diff. score1.11.31.81.11.31.31.11.21.11.21.11.2-1.2-1.11.0
Locomotion velocity, session 10.50.61.50.2-1.2-0.2-0.8-0.7-0.9-0.5-0.7-0.81.20.80.1
Locomotion distance, session 10.40.51.90.5-1.2-0.1-0.7-0.4-0.7-0.4-0.5-0.71.40.70.5
Locomotion velocity, session 21.71.92.8-1.3-1.6-1.6-1.7-1.2-1.4-1.5-1.3-1.31.51.3-0.7
Locomotion distance, session 21.52.14.6-0.6-2.1-1.2-1.7-1.4-1.7-1.3-1.4-1.42.01.4-0.2
Locomotion velocity, session 30.10.10.20.50.30.10.30.30.30.20.30.4-0.0-0.30.3
Locomotion distance, session 31.01.01.8-0.5-1.0-1.4-0.9-1.1-1.1-1.2-1.0-1.20.91.2-0.4
Stereotopy head waving bouts, day 30.40.41.2-1.10.80.10.20.30.70.40.30.5-0.7-0.6-1.1
Stereotopy head waving duration, day 30.30.30.6-0.30.70.40.30.50.70.70.40.6-0.7-0.7-0.3
Locomotion velocity, session 70.60.62.1-0.60.30.80.80.60.80.70.61.2-0.7-1.5-0.5
Locomotion distance, session 70.00.00.1-0.2-0.30.20.10.0-0.00.10.00.20.3-0.30.1
Stereotopy head waving bouts, day 70.30.30.50.50.40.60.30.60.40.70.50.6-0.7-0.60.4
Stereotopy head waving duration, day 71.01.22.20.81.11.21.01.11.01.21.11.2-1.5-1.20.6
Locomotion velocity, session 80.30.40.60.80.70.70.50.50.60.60.70.6-0.2-0.50.7
Locomotion distance, session 80.10.10.40.1-0.6-0.1-0.5-0.2-0.5-0.1-0.3-0.00.50.00.4
Degree of sensitization distance0.30.30.60.50.30.80.40.60.40.70.50.70.0-0.70.6
Degree of sensitization stereotypy0.20.20.40.70.30.60.40.50.30.60.50.5-0.6-0.40.5
Conditioned locomotion2.12.45.0-2.0-1.3-1.6-1.6-1.6-1.3-1.6-1.7-1.30.61.4-2.2
Cocaine response after cond. corrected0.20.20.6-0.10.40.40.50.40.40.50.30.5-0.8-0.6-0.1
Cocaine response after cond. not corrected0.70.81.20.40.80.91.01.00.91.10.91.1-1.1-1.00.4
Cocaine response before conditioning0.81.01.40.90.81.11.01.10.91.21.21.1-0.6-0.91.0
Saline control response1.82.43.31.51.41.71.81.61.71.61.51.6-1.2-1.70.8
Bone: connectivity density0.30.41.40.50.70.61.20.60.90.50.60.60.1-0.5-0.0
Bone: cortical apparent density1.82.43.3-0.9-1.5-1.8-1.6-1.6-1.7-1.7-1.6-1.81.51.8-0.7
Bone: cortical area0.20.21.61.3-0.20.40.10.20.20.10.1-0.30.50.30.7
Bone: cortical porosity0.20.20.7-0.8-0.20.70.2-0.10.30.10.10.4-0.2-0.5-0.8
Bone: cortical porosity0.20.21.1-1.1-0.20.50.1-0.10.30.10.10.2-0.1-0.4-1.1
Bone: cortical thickness2.33.85.4-0.6-2.2-1.7-1.9-2.1-2.0-2.1-2.2-2.32.02.2-1.1
Bone: cortical thickness0.00.00.1-0.10.30.0-0.2-0.2-0.1-0.2-0.20.1-0.4-0.0-0.3
Bone: cortical tissue density1.72.33.1-0.9-1.4-1.8-1.6-1.6-1.6-1.6-1.5-1.71.41.7-0.7
Condit. Reinf. active minus inactive responses0.20.20.8-0.9-0.7-0.5-0.3-0.1-0.50.0-0.1-0.20.20.1-0.2
Condit. Reinf. active-inactive response ratio0.50.51.1-0.20.50.40.61.00.51.11.00.9-0.4-0.90.6
Condit. Reinf. active responses0.20.20.8-0.7-0.9-0.4-0.4-0.3-0.6-0.2-0.4-0.40.40.4-0.3
Condit. Reinf. inactive responses0.70.81.4-0.1-1.2-0.5-0.8-1.0-1.0-0.9-1.1-1.10.91.1-0.5
Incentive salience index mean0.10.10.6-0.5-0.8-0.4-0.20.0-0.50.1-0.0-0.10.40.10.2
Condit. Reinf. lever presses0.10.10.6-0.2-0.8-0.2-0.2-0.0-0.4-0.0-0.1-0.20.70.20.2
Condit. Reinf. active minus inactive responses1.01.35.42.31.11.10.70.90.80.91.00.7-0.5-0.41.9
Condit. Reinf. active-inactive response ratio2.02.44.01.82.01.61.51.41.71.41.61.4-1.5-1.11.3
Condit. Reinf. active responses0.70.94.82.20.70.80.40.60.40.70.60.4-0.1-0.21.8
Condit. Reinf. inactive responses0.50.61.81.3-0.8-0.2-0.8-0.4-0.9-0.2-0.5-0.61.00.61.2
Condit. Reinf. lever presses0.81.15.92.40.61.10.10.50.30.70.60.3-0.2-0.12.1
Condit. Reinf. lever reinforcers received0.50.74.62.20.30.6-0.20.1-0.10.30.1-0.10.30.31.8
Conditioned reinforcement - actives0.40.81.90.11.01.00.70.81.00.80.71.0-1.4-1.0-0.2
Conditioned reinforcement - inactives0.20.30.6-0.1-0.7-0.4-0.3-0.6-0.6-0.6-0.8-0.5-0.10.4-0.4
Conditioned locomotion0.20.30.50.00.50.70.30.60.60.60.50.7-0.7-0.60.1
Patch foraging indifference point 0 sec0.30.52.21.5-0.10.5-0.20.4-0.00.40.2-0.21.00.41.5
Patch foraging indifference point AUC0.30.52.60.9-0.5-0.4-0.4-0.1-0.7-0.2-0.1-0.50.70.71.6
Delay disc. indifference point, 0s delay1.21.32.2-0.4-1.3-1.0-1.3-1.2-1.4-1.2-1.2-1.40.51.5-0.1
Delay disc. indifference point, 16s delay4.14.59.2-2.2-2.3-3.0-1.9-2.1-2.3-2.1-2.1-1.92.01.7-1.4
Delay disc. indifference point, 2s delay0.20.20.90.90.30.40.40.40.30.40.40.3-0.1-0.30.7
Delay disc. indifference point, 24s delay0.80.91.6-1.3-1.2-1.1-0.2-1.0-1.0-1.0-1.1-0.60.40.4-1.0
Delay disc. indifference point, 4s delay0.20.20.80.9-0.4-0.5-0.00.2-0.20.20.2-0.40.60.60.8
Delay disc. indifference point, 8s delay0.30.31.00.7-0.6-0.6-0.50.2-0.40.20.2-0.40.90.61.0
Indifference point function ln k0.71.22.50.71.11.61.31.11.31.11.01.2-0.8-1.20.1
Indifference point function log k0.71.22.50.71.11.61.31.11.31.11.01.2-0.8-1.20.1
Patch foraging total patch changes 0 sec0.20.52.01.4-0.20.3-0.30.1-0.20.1-0.1-0.41.20.51.1
Patch foraging total patch changes 12 sec1.21.53.71.8-1.2-0.5-1.1-0.7-1.3-0.7-0.8-1.11.41.31.9
Patch foraging total patch changes 18 sec0.20.30.90.90.50.40.30.70.40.60.40.6-0.2-0.50.8
Patch foraging total patch changes 24 sec0.10.10.30.2-0.5-0.2-0.3-0.2-0.3-0.2-0.3-0.50.50.50.2
Patch foraging total patch changes 6 sec0.50.82.00.2-0.8-0.7-1.2-0.6-1.0-0.6-0.8-1.01.41.20.7
Patch foraging time to switch 0 sec0.61.36.3-2.50.8-0.7-0.3-0.20.5-0.20.00.5-1.5-0.6-2.3
Patch foraging water rate 0 sec0.81.77.32.70.21.51.31.00.61.10.90.40.4-0.32.3
Patch foraging water rate 12 sec0.40.96.02.50.00.90.40.40.10.40.10.30.7-0.11.7
Patch foraging water rate 18 sec0.30.52.31.5-0.20.70.50.50.10.40.40.10.6-0.01.4
Patch foraging water rate 24 sec0.10.21.11.1-0.00.1-0.0-0.2-0.1-0.0-0.3-0.10.40.10.6
Patch foraging water rate 6 sec0.60.92.11.50.41.01.30.90.90.90.91.0-0.3-1.00.9
Seeking ratio, delayed vs. immediate footshock0.20.21.10.6-0.20.3-0.60.2-0.20.30.4-0.30.70.41.1
Distance traveled before self-admin1.01.32.01.41.11.11.31.41.21.31.40.7-0.6-0.61.2
Distance traveled after self-admin2.32.84.71.31.72.21.82.12.02.02.01.3-1.3-1.20.7
Extensor digitorum longus weight1.87.08.92.52.52.92.72.82.52.73.02.8-2.1-2.82.4
Bone: elastic displacement0.20.21.01.00.20.40.30.30.10.30.30.0-0.60.20.7
Bone: elastic work0.81.03.92.00.60.90.90.90.61.00.90.4-0.4-0.11.7
Bone: endosteal estimation5.612.216.22.33.63.43.84.03.93.94.03.6-3.1-3.62.2
Bone: endosteal perimeter2.65.67.61.92.42.62.72.72.82.72.62.1-2.0-2.11.3
Epididymis fat weight0.92.95.4-1.1-1.1-2.0-1.2-2.1-1.4-2.3-2.3-1.80.21.7-2.0
Delta time in closed arm before/after self-admin0.10.10.2-0.20.4-0.2-0.4-0.30.1-0.4-0.20.00.20.1-0.3
Delta time in open arm before/after self-admin0.20.20.8-0.90.2-0.30.1-0.4-0.0-0.3-0.50.10.0-0.4-0.9
Diff in mean of infusions in LGA sessions0.81.01.80.51.11.11.21.31.21.31.30.6-1.0-0.40.4
Delay discount exponential model param0.40.51.2-0.01.01.10.60.40.80.40.40.7-1.1-0.7-0.3
Extinction: sum of active levers before priming0.40.41.8-1.20.2-0.7-0.4-0.6-0.0-0.6-0.40.1-0.5-0.2-1.3
Active lever presses in extinction session 60.10.10.2-0.4-0.2-0.10.30.10.00.20.00.2-0.4-0.3-0.4
Bone: final force0.20.41.01.0-0.80.0-0.3-0.1-0.4-0.0-0.1-0.61.00.61.0
Bone: final moment0.20.31.10.7-0.9-0.1-0.5-0.2-0.5-0.2-0.2-0.61.00.60.7
Food consumed during 24 hour testing period3.85.26.52.22.42.22.42.52.32.42.62.3-2.2-2.02.1
Glucose0.50.81.7-0.91.10.61.00.51.00.10.40.9-1.3-1.0-1.3
Heart weight0.30.51.30.10.60.31.10.30.60.30.61.0-1.1-1.0-0.5
Delay discount hyperbolic model param0.20.30.8-0.20.80.90.30.20.60.20.20.5-0.9-0.5-0.4
Intermittent access intake day 1-15 change0.91.93.0-1.0-1.4-1.5-1.7-1.5-1.4-1.6-1.5-1.20.51.3-1.1
Intermittent access intake escalation0.81.62.6-0.6-1.4-1.4-1.6-1.4-1.4-1.4-1.4-1.20.71.2-0.8
Intermittent access intake escalation 20.40.40.8-0.3-0.9-0.8-0.9-0.6-0.8-0.7-0.7-0.60.10.6-0.4
Intermitt. access day 1 inactive lever presses0.10.52.91.7-0.40.5-0.30.1-0.40.10.0-0.3-0.00.51.3
Intermitt. access day 15 inactive lever presses0.10.20.60.2-0.5-0.3-0.1-0.7-0.6-0.7-0.8-0.2-0.50.3-0.2
Intermitt. access escalation Index0.60.91.90.00.20.71.41.20.91.31.20.9-0.9-1.0-0.0
Intermittent access day 1 total infusions0.71.13.0-0.61.20.91.10.81.20.90.71.2-1.7-1.3-0.6
Intermittent access day 15 total infusions0.30.52.1-1.40.1-0.20.1-0.10.2-0.1-0.30.4-1.2-0.5-1.5
Intermittent access terminal intake (last 3 days)0.71.03.1-0.90.70.70.80.61.00.70.51.1-1.8-1.2-1.1
Intermittent access total infusions0.91.13.3-0.81.00.80.90.61.00.60.61.2-1.8-1.4-0.8
Intermittent access day 1 locomotion0.40.50.8-0.40.70.70.70.70.90.80.60.7-0.8-0.8-0.5
Intermittent access day 15 total locomotion0.20.41.1-1.1-0.4-0.5-0.7-0.6-0.3-0.6-0.5-0.3-0.40.3-1.0
Intermittent access total locomotion0.40.50.90.40.81.00.40.80.90.80.80.7-0.9-0.70.2
Intermittent access standard deviation0.51.11.6-1.0-0.8-1.1-1.2-1.1-0.9-1.1-1.3-0.91.00.9-1.0
Left kidney weight0.73.511.53.41.12.01.31.91.31.71.91.3-0.5-1.12.8
Right kidney weight0.73.413.03.61.01.71.61.71.21.61.81.3-0.2-1.12.8
Cocaine induced anxiety0.60.91.5-0.50.90.91.20.91.00.90.91.0-1.1-1.1-0.3
Post-drug Anxiety0.20.20.70.70.10.50.50.50.20.50.5-0.20.40.30.9
Baseline Anxiety2.52.96.92.1-1.4-0.7-1.4-0.8-1.6-0.8-0.9-2.22.62.51.9
Tail length1.03.97.40.1-2.7-1.8-2.2-1.8-2.3-1.8-1.4-2.22.72.20.5
Length with tail0.31.35.52.0-1.20.2-0.60.1-0.70.20.4-0.61.40.72.4
Length without tail1.34.18.22.81.32.31.52.21.42.42.11.7-1.3-1.62.9
Times rat made contact with spout0.50.53.31.8-0.10.4-0.10.3-0.10.40.2-0.0-0.30.21.5
Lifetime Intake0.91.13.3-0.71.10.81.00.61.00.60.51.3-1.8-1.5-0.7
Liver weight, left0.20.30.70.10.60.00.50.40.60.00.50.7-0.8-0.6-0.3
Liver weight, right0.00.00.20.30.00.1-0.30.1-0.1-0.00.0-0.10.50.10.4
Locomotor activity0.10.20.80.9-0.30.30.40.20.00.30.2-0.20.10.20.8
Locomotor testing distance0.20.41.11.0-0.11.00.50.60.40.80.40.2-0.2-0.20.8
Locomotor testing rearing0.20.30.90.90.31.00.60.70.70.90.40.1-0.0-0.20.1
Locomotion in novel chamber1.62.14.4-1.1-1.4-1.9-2.1-1.6-1.5-1.5-1.3-1.31.21.3-0.8
Locomotion in novel chamber post-restriction0.40.61.80.40.60.30.80.80.60.80.90.9-1.3-0.80.5
Fecal boli incidents, locomotor time 11.01.42.9-0.30.81.01.51.31.31.31.41.5-1.2-1.7-0.1
Change in fecal boli incidents, locomotor task0.60.61.50.9-0.3-0.5-0.8-0.3-0.7-0.4-0.6-0.81.20.91.1
Time >=10cm from walls, locomotor time 11.41.52.5-0.11.40.91.51.21.41.21.31.4-1.6-1.3-0.1
Bouts of movement, locomotor time 17.28.213.1-1.7-3.6-3.3-2.5-2.8-3.3-2.8-2.7-3.23.23.2-0.9
Total resting periods, locomotor time 16.67.312.1-1.4-3.5-3.0-2.5-2.6-3.2-2.6-2.5-3.13.23.0-0.6
Rest time, locomotor task time 12.02.54.1-1.5-2.0-2.0-1.5-1.5-1.7-1.5-1.5-1.51.51.3-1.0
Distance moved, locomotor task time 10.20.30.70.10.50.80.80.20.50.20.20.5-0.8-0.4-0.0
Vertical activity count, locomotor time 10.00.00.2-0.40.4-0.30.00.00.20.00.1-0.10.10.1-0.1
Time >=10cm from walls, locomotor time 20.10.10.6-0.80.40.20.30.10.20.20.00.5-0.4-0.5-0.5
Bouts of movement, locomotor time 23.04.76.8-1.5-2.6-1.9-2.4-2.4-2.5-2.4-2.4-2.32.02.1-1.2
Total resting periods, locomotor time 22.74.86.8-1.5-2.6-2.1-2.4-2.3-2.5-2.3-2.3-2.32.12.3-1.1
Rest time, locomotor task time 24.15.28.3-2.0-2.4-2.9-2.4-2.5-2.4-2.5-2.3-2.21.92.1-1.7
Distance moved, locomotor task time 20.20.31.01.00.30.80.50.30.30.30.10.2-0.0-0.00.8
Vertical activity count, locomotor time 21.01.42.10.51.41.31.21.21.31.31.21.3-1.2-1.30.6
Light reinforcement 10.20.51.3-1.0-0.9-0.5-0.3-0.5-0.6-0.5-0.6-0.80.30.7-1.1
Light reinforcement 20.10.10.20.2-0.10.10.30.30.10.40.5-0.00.20.10.5
Bone: marrow area5.612.216.22.33.63.43.94.03.93.94.03.6-3.1-3.62.1
Bone: maximum diameter3.05.68.93.02.12.52.42.72.42.52.62.0-1.6-1.92.4
Bone: maximum force0.20.41.51.2-0.20.60.30.60.30.60.70.10.6-0.11.2
Bone: maximum moment0.20.31.01.0-0.20.50.30.50.30.50.60.10.5-0.11.0
Mean time between licks in bursts0.10.20.6-0.2-0.5-0.8-0.5-0.2-0.6-0.5-0.4-0.30.30.40.1
Mean num. licks in bursts0.30.41.20.9-0.8-0.3-0.70.0-0.60.1-0.2-0.60.80.71.1
Cd content in liver1.92.18.4-2.7-0.3-1.6-0.6-1.3-0.5-1.5-1.3-0.5-0.50.2-2.9
Co content in liver1.11.22.1-0.7-1.4-1.0-1.2-1.0-1.4-1.2-1.3-1.20.81.2-0.5
Cu content in liver0.20.20.90.9-0.4-0.0-0.20.0-0.20.20.1-0.30.30.20.9
Fe content in liver0.30.31.81.4-0.20.2-0.20.2-0.10.10.1-0.40.40.51.1
K content in liver0.90.92.91.70.31.01.01.00.61.40.80.30.1-0.21.3
Mg content in liver1.91.96.72.61.01.01.21.40.91.61.30.6-0.2-0.32.3
Mn content in liver0.70.82.01.40.81.31.00.90.81.10.70.6-0.3-0.60.8
Na content in liver0.60.72.01.40.71.00.60.90.71.10.80.20.1-0.21.1
Rb content in liver0.10.10.40.3-0.2-0.6-0.1-0.2-0.1-0.3-0.5-0.30.20.2-0.0
Se content in liver0.50.61.71.30.80.90.50.80.60.80.40.2-1.0-0.00.7
Sr content in liver1.31.11.7-1.2-0.7-1.3-1.0-1.3-0.9-1.0-1.2-0.90.70.8-1.2
Zn content in liver0.91.12.50.01.00.61.60.91.41.01.01.1-1.3-1.1-0.6
Bone: minimum diameter0.00.10.20.40.10.20.20.40.40.20.30.1-0.0-0.30.2
Time in familiar zone, hab. session 10.00.00.10.20.10.3-0.1-0.2-0.0-0.0-0.10.20.1-0.3-0.0
Time in novel zone, hab. session 10.10.10.4-0.30.20.20.30.30.30.60.20.3-0.6-0.3-0.3
Total zone transitions, hab. session 13.54.88.3-1.2-2.9-2.1-2.3-2.4-2.3-2.0-2.4-2.32.62.0-1.4
Total locomotion distance, hab. session 15.98.312.3-2.1-3.5-2.8-3.2-3.1-3.0-2.9-3.1-2.93.12.7-1.9
Locomotion velocity, hab. session 15.88.212.2-1.9-3.5-2.8-3.2-3.0-3.0-2.9-3.0-2.93.22.7-1.6
Time in familiar zone, hab. session 20.10.10.60.8-0.00.3-0.3-0.4-0.4-0.4-0.40.10.1-0.10.3
Time in novel zone, hab. session 21.01.11.8-0.51.20.61.21.21.31.31.10.9-1.1-0.9-0.3
Total zone transitions, hab. session 22.63.36.50.0-2.5-1.4-2.1-1.6-2.1-1.7-1.6-1.92.51.90.4
Total locomotion distance, hab. session 25.87.611.3-1.9-3.4-2.6-3.1-2.8-3.0-2.9-2.9-2.83.12.5-1.4
Locomotion velocity, hab. session 26.58.712.9-2.1-3.6-2.8-3.3-3.0-3.2-3.2-3.0-3.03.32.7-1.6
Novel to familiar place preference ratio0.80.81.40.30.51.20.91.10.81.01.11.0-1.0-1.00.5
Novelty place preference1.61.72.70.40.91.61.41.51.31.41.51.5-1.4-1.50.5
Time in novel zone, NPP test2.52.74.00.51.22.01.81.91.71.81.81.9-1.8-1.90.6
Total zone transitions, NPP test2.43.56.7-0.5-2.6-1.8-2.1-1.7-2.2-1.7-1.8-1.92.32.0-0.1
Total locomotion distance, NPP test3.04.16.6-1.5-2.6-1.9-2.2-2.1-2.2-2.1-2.2-2.12.02.0-1.4
Locomotion velocity, NPP test4.66.49.0-1.7-3.0-2.5-2.8-2.6-2.7-2.7-2.7-2.72.62.6-1.6
Intraocular pressure0.20.31.11.10.30.50.40.60.40.60.50.20.3-0.01.0
Delta distance traveled before/after self-admin0.40.40.7-0.10.60.90.30.60.70.60.60.6-0.8-0.6-0.4
Delta ambulatory time before/after self-admin0.91.11.80.21.11.30.81.11.31.01.11.2-1.3-1.1-0.2
Parametrial fat weight0.20.52.6-0.80.7-0.50.1-0.30.5-0.5-0.10.6-1.0-0.6-1.6
Pavlov. Cond. lever latency0.20.20.50.50.60.70.40.30.40.40.20.3-0.6-0.30.1
Pavlov. Cond. magazine entry latency0.50.74.2-2.0-0.0-0.7-0.4-0.4-0.1-0.5-0.40.3-0.4-0.4-1.6
Pavlov. Cond. change in total contacts0.70.72.7-1.7-0.8-1.0-0.9-0.7-0.7-0.6-0.7-0.40.60.4-0.9
Pavlov. Cond. index score0.20.32.0-1.4-0.1-0.6-0.3-0.1-0.1-0.3-0.10.2-0.1-0.2-0.8
Pavlov. Cond. latency score0.30.31.6-1.3-0.4-0.8-0.5-0.4-0.4-0.5-0.4-0.10.20.1-0.7
Pavlov. Cond. lever contacts0.10.21.1-1.1-0.2-0.6-0.1-0.2-0.1-0.3-0.10.00.10.0-0.6
Pavlov. Cond. magazine entry number0.30.42.71.6-0.20.70.40.30.20.50.3-0.20.50.31.0
Pavlov. Cond. intertrial magazine entries0.20.20.90.90.10.50.30.40.20.60.4-0.10.10.20.9
Pavlov. Cond. lever-magazine prob. diff.0.30.32.6-1.60.0-0.6-0.2-0.1-0.1-0.3-0.10.2-0.1-0.3-0.9
Pavlov. Cond. response bias0.30.42.8-1.70.1-0.6-0.1-0.10.1-0.3-0.10.3-0.4-0.3-1.1
Pavlov. Cond. lever latency1.11.46.9-2.6-0.8-1.3-0.2-0.7-0.4-0.9-0.7-0.50.10.3-2.4
Pavlov. Cond. magazine entry latency1.01.21.8-0.3-1.1-0.9-1.4-1.3-1.1-1.2-1.3-1.31.21.2-0.5
Pavlov. Cond. change in total contacts0.50.95.82.40.30.7-0.50.0-0.10.10.1-0.10.50.21.9
Pavlov. Cond. index score0.30.53.21.80.30.5-0.4-0.0-0.00.10.0-0.10.30.21.3
Pavlov. Cond. latency score0.40.53.51.90.20.5-0.4-0.1-0.10.1-0.1-0.30.50.41.4
Pavlov. Cond. lever contacts1.31.87.32.71.01.60.40.90.71.21.00.7-0.4-0.62.4
Pavlov. Cond. magazine entry number0.10.10.3-0.5-0.00.10.60.40.20.30.30.4-0.5-0.3-0.2
Pavlov. Cond. intertrial magazine entries0.10.10.30.30.20.30.50.60.30.50.40.30.1-0.20.4
Pavlov. Cond. lever-magazine prob. diff.0.40.53.01.70.00.4-0.5-0.2-0.2-0.0-0.2-0.30.50.31.3
Pavlov. Cond. response bias0.40.52.71.70.50.9-0.10.20.20.40.30.3-0.0-0.21.4
Time in closed arm before self-admin2.32.93.81.21.61.91.71.91.71.91.91.8-1.5-1.81.2
Time in closed arm after self-admin0.30.41.31.00.20.6-0.10.70.30.60.5-0.20.50.41.2
Time in open arm before self-admin0.30.31.4-0.90.1-0.60.1-0.40.0-0.5-0.30.1-0.6-0.1-1.2
Time in open arm after self-admin1.01.12.1-0.51.30.71.40.51.20.60.51.2-1.5-1.4-1.1
Bone: periosteal estimation3.06.48.72.22.52.62.72.92.82.82.82.3-2.0-2.41.8
Bone: periosteal perimeter1.83.14.42.11.42.12.12.02.02.01.91.3-1.0-1.31.4
Bone: post-yield work1.21.72.71.10.81.41.31.61.31.61.61.4-0.4-1.41.2
Progressive ratio test 1 active lever presses1.11.42.8-0.41.31.31.11.01.31.10.81.5-1.5-1.7-0.3
Progressive ratio test 1 breakpoint1.21.52.8-0.31.41.31.11.11.41.10.91.5-1.5-1.7-0.2
Progressive ratio test 1 inactive lever presses0.40.52.61.60.11.3-0.10.60.30.50.20.1-0.0-0.01.1
Progressive ratio test 2 active lever presses0.10.20.60.10.30.40.30.20.30.20.20.5-0.8-0.60.1
Progressive ratio test 2 breakpoint0.10.10.50.20.20.40.20.20.20.20.10.5-0.7-0.50.1
Progressive ratio test 2 inactive lever presses0.30.52.00.10.80.70.90.30.70.30.30.9-1.4-0.9-0.4
Incentive Sensitization - Responses0.20.20.40.4-0.5-0.5-0.5-0.5-0.6-0.5-0.5-0.50.30.60.1
Incentive Sensitization - Breakpoint0.30.40.70.2-0.7-0.8-0.6-0.8-0.8-0.8-0.7-0.70.30.7-0.0
Sum of active levers in priming session hrs 5-60.30.31.0-1.0-0.2-0.8-0.0-0.5-0.2-0.5-0.5-0.0-0.3-0.1-1.0
Progressive ratio0.50.71.7-1.30.50.70.60.60.70.60.40.8-1.2-1.1-1.1
Food seeking constrained by brief footshock0.70.92.71.40.10.90.90.80.30.91.00.9-0.5-0.81.6
Seeking ratio, punishment vs. effort0.71.05.02.2-0.3-0.00.00.1-0.50.10.2-0.41.10.72.2
Retroperitoneal fat weight0.72.95.2-0.3-1.4-2.0-1.7-2.1-1.5-2.3-2.0-1.91.11.9-1.3
Reaction time number correct0.10.30.90.9-0.40.60.80.50.30.50.20.20.2-0.30.3
Reaction time mean minus median0.10.21.2-0.80.3-0.30.00.00.1-0.0-0.10.2-1.1-0.2-0.5
Reaction time mean minus median AUC0.10.31.3-1.2-0.1-0.30.1-0.00.1-0.1-0.3-0.0-0.9-0.1-1.1
Reaction time num false alarms1.11.52.1-0.7-1.2-1.3-1.4-1.2-1.0-1.2-1.4-1.51.31.4-1.0
Reaction time num false alarms AUC0.60.91.4-0.1-0.9-1.0-1.1-0.9-0.8-0.9-1.0-1.11.21.1-0.6
Reaction time trials correct on left0.10.30.90.9-0.40.60.80.50.30.50.20.20.2-0.30.3
Reaction time trials on left0.20.31.01.0-0.40.70.90.60.40.50.30.30.2-0.40.4
Reaction time mean0.20.20.8-0.80.1-0.5-0.2-0.5-0.2-0.5-0.5-0.1-0.60.1-0.9
Reaction time mean AUC0.10.10.5-0.60.3-0.20.0-0.2-0.0-0.2-0.20.0-0.7-0.0-0.5
Median of all reaction times0.30.41.1-0.9-0.2-0.7-0.4-0.9-0.4-0.8-0.8-0.4-0.10.4-1.1
Reaction time omissions0.00.00.10.2-0.3-0.0-0.30.2-0.20.2-0.0-0.10.10.10.4
Reaction time false alarm rate1.01.42.3-0.9-0.8-1.4-1.5-1.3-1.0-1.2-1.3-1.31.11.3-1.0
Reaction time premature initiation rate0.81.12.10.70.71.41.21.41.11.51.10.8-1.1-0.90.5
Reaction time premature initiations0.91.62.91.30.51.71.61.61.21.71.20.9-0.9-1.00.8
Std. dev. reaction times0.10.21.4-0.50.60.00.20.10.30.10.00.4-1.2-0.4-0.5
Reaction time trials completed0.20.31.01.0-0.40.70.90.60.40.50.30.30.2-0.40.4
Reaction time trials AUC0.10.30.80.9-0.50.60.90.50.30.50.20.20.3-0.30.4
Run reversals in cocaine runway, females0.30.30.60.5-0.4-0.4-0.7-0.2-0.5-0.3-0.4-0.60.80.80.6
Run reversals in cocaine runway, males0.30.31.71.3-0.10.60.00.20.00.20.30.00.6-0.01.1
Latency to leave start box in cocaine runway0.20.20.70.1-0.70.1-0.50.2-0.40.10.2-0.50.50.60.9
Latency to leave start box in cocaine runway, F0.20.20.60.1-0.8-0.2-0.6-0.0-0.6-0.10.0-0.50.50.60.7
Latency to leave start box in cocaine runway, M0.20.20.5-0.0-0.5-0.0-0.5-0.0-0.5-0.0-0.1-0.60.70.70.6
Std. dev. time between licks in bursts0.50.63.11.5-0.70.2-0.50.2-0.60.20.1-0.30.90.41.8
Total sessions with >9 infusions0.60.71.90.31.11.00.70.61.00.50.31.3-1.0-1.4-0.1
Short access day 1 total inactive lever presses0.60.83.61.90.31.10.30.80.30.70.80.4-0.1-0.21.8
Short access day 10 total inactive lever presses0.20.40.91.0-1.00.4-0.50.0-0.6-0.0-0.1-0.60.70.80.8
Short access day 1 total infusions0.30.40.9-0.90.50.30.80.20.60.2-0.10.8-0.9-1.0-0.9
Short access day 10 total infusions1.82.34.3-0.21.91.41.41.41.81.31.21.8-2.1-1.9-0.4
Short access total infusions1.31.73.7-0.71.61.01.20.91.50.90.71.7-1.9-1.9-0.8
Short access day 1 locomotion0.50.72.0-0.50.90.70.80.51.00.40.21.2-0.9-1.4-0.7
Short access day 10 total locomotion0.20.31.11.00.40.9-0.70.40.40.40.3-0.10.40.30.5
Short access total locomotion0.20.20.50.20.70.60.10.40.70.30.20.7-0.5-0.7-0.2
One hour access (0.3 mA shock)0.70.83.7-1.50.0-0.5-0.1-0.70.0-0.7-0.60.2-1.4-0.5-1.9
Compulsive drug intake0.10.10.40.70.10.20.60.10.20.10.2-0.10.00.20.1
One hour access (shock baseline)0.40.62.7-1.60.1-0.4-0.3-0.5-0.0-0.5-0.50.3-1.1-0.5-1.5
Social response proportion2.83.24.6-1.3-1.9-2.2-1.9-1.8-1.8-1.9-1.7-1.82.01.8-1.0
Social responses2.43.14.1-0.8-2.0-1.9-1.7-2.0-1.8-1.9-1.9-1.81.91.8-1.1
Social time0.40.50.8-0.8-0.8-0.8-0.6-0.8-0.6-0.9-0.7-0.60.50.6-0.8
Soleus weight2.16.19.43.02.12.52.42.82.22.53.02.0-1.7-1.93.1
Bone: stiffness0.10.20.80.2-0.7-0.3-0.6-0.3-0.4-0.3-0.3-0.50.90.30.3
Tibialis anterior weight4.615.519.83.24.24.04.34.34.24.14.44.0-3.4-3.82.9
Time to tail flick, vehicle, before self-admin0.80.83.1-1.80.2-0.10.4-0.10.3-0.2-0.10.6-1.4-1.0-1.7
Time to tail flick, vehicle, after self-admin0.50.61.30.31.20.30.61.00.91.01.10.6-0.6-0.50.7
Time to tail flick, test, before self-admin0.20.20.40.10.50.40.30.60.40.60.60.5-0.5-0.50.5
Time to tail flick, test, after self-admin0.10.10.4-0.6-0.3-0.2-0.2-0.3-0.2-0.4-0.10.3-0.3-0.5-0.4
Delta time to tail flick, vehicle, before/after SA0.50.52.11.40.50.3-0.20.60.30.60.6-0.10.50.41.5
Delta time to tail flick, test, before/after SA0.00.00.10.10.10.1-0.1-0.10.1-0.10.10.2-0.0-0.2-0.1
Tibia length1.02.84.41.21.81.61.51.91.82.12.01.6-1.1-1.51.4
Ambulatory time before self-admin0.40.61.11.00.60.70.81.10.71.00.90.3-0.2-0.30.9
Ambulatory time after self-admin2.22.64.11.21.72.01.62.01.92.01.91.3-1.2-1.20.8
Bone: tissue strength3.03.05.4-0.5-2.2-1.8-1.9-1.6-1.9-1.6-1.5-2.02.32.0-0.0
Total heroin consumption0.10.10.6-0.60.2-0.10.2-0.20.1-0.2-0.10.1-0.2-0.1-0.8
Bone: trabecular number0.10.10.40.50.10.00.60.30.30.10.20.30.6-0.30.2
Bone: trabecular spacing4.35.77.8-1.2-2.5-2.7-2.6-2.6-2.7-2.5-2.6-2.81.92.7-1.0
Bone: trabecular thickness0.40.61.81.30.21.30.70.70.60.70.60.60.1-0.40.7
Bone: trabecular tissue density0.20.30.70.30.20.80.40.50.60.80.70.5-0.7-0.60.2
Water consumed over 24 hours2.02.75.32.31.11.81.51.81.31.71.81.4-1.2-1.22.2
Number of responses in last shaping day5.45.911.10.73.32.32.32.33.02.22.22.8-3.0-2.70.3