Hub : Genes

Gclc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg isoform ratio XM_039080870.1 0.1 0.07 5.5e-03 0.04 0.07 0.08 0.06 3.4e-02 6.2e-03 4.2e-03 1.2e-02
2 PL mRNA stability Gclc 0.04 0.03 3.8e-04 0.01 0.02 0.01 0.02 1.7e-02 4.3e-03 8.7e-03 6.4e-03
3 PL gene expression Gclc 0.03 0.02 5.7e-03 -0 0.02 0.01 0 4.7e-01 3.8e-03 3.5e-02 8.3e-02
4 Adipose gene expression Gclc 0.1 0.05 3.1e-12 0.07 0.1 0.1 0.1 1.2e-08 3.1e-11 9.0e-11 7.6e-11
5 Eye gene expression Gclc 0.69 0.16 9.5e-06 0.26 0.01 0.05 0.07 6.5e-05 2.0e-01 6.1e-02 3.7e-02
6 Brain mRNA stability Gclc 0.13 0.07 8.6e-09 0.1 0.1 0.1 0.09 2.2e-09 3.8e-09 3.7e-09 5.7e-09
7 RMTg isoform ratio NM_012815.2 0.11 0.08 5.0e-03 0.04 0.07 0.06 0.05 3.3e-02 6.9e-03 1.0e-02 1.6e-02
8 Brain alternative polyA XM_039080870.1 0.05 0.03 1.5e-03 0.04 0.03 0.04 0.04 2.9e-04 6.7e-04 1.3e-04 2.3e-04
9 Brain alternative polyA NM_012815.2 0.05 0.04 1.2e-03 0.04 0.03 0.04 0.04 2.7e-04 5.0e-04 6.8e-05 2.0e-04
10 Liver gene expression Gclc 0.03 0.02 9.5e-04 0.02 0.02 0.02 0.02 9.6e-04 3.2e-03 4.5e-03 5.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.61.02.01.11.41.41.2-1.1-0.31.00.2-0.11.0
Area under the delay curve0.40.40.7-0.7-0.6-0.3-0.80.50.8-0.7-0.70.7-0.6
BMI with tail4.815.626.85.24.22.54.0-4.0-4.23.73.8-3.83.6
BMI without tail1.12.45.02.21.81.61.6-1.4-1.51.41.1-1.01.5
Body weight3.614.920.84.64.14.23.6-4.2-4.53.13.5-3.52.9
Weight adjusted by age1.82.13.01.31.71.31.6-1.6-1.51.41.4-1.41.1
Bone surface2.95.27.52.62.72.12.6-2.6-1.82.41.6-1.62.3
Bone volume1.72.85.11.92.12.31.9-2.0-1.21.60.8-0.81.5
Breakpoint value in progressive ratio session0.80.81.41.01.0-0.31.2-0.7-0.51.20.9-0.91.2
Number of licking bursts1.21.42.71.40.90.20.9-1.2-1.60.91.6-1.50.9
Context. condit. distance diff. score1.11.42.41.01.10.91.0-1.4-1.50.91.4-1.40.9
Locomotion velocity, session 10.60.71.3-0.7-0.70.2-0.80.60.8-0.9-1.11.1-0.9
Locomotion distance, session 10.40.50.7-0.8-0.50.5-0.60.50.6-0.8-0.90.9-0.7
Locomotion velocity, session 21.92.23.5-1.9-1.5-1.3-1.41.51.8-1.2-1.51.5-1.2
Locomotion distance, session 22.02.84.8-2.2-1.5-0.5-1.61.62.0-1.5-1.91.9-1.5
Locomotion velocity, session 30.10.10.50.30.30.50.3-0.7-0.40.30.3-0.30.1
Locomotion distance, session 30.70.81.0-1.0-0.9-0.4-0.90.81.0-0.8-0.90.9-0.9
Stereotopy head waving bouts, day 30.50.61.10.80.3-1.10.7-0.5-0.60.90.9-0.90.8
Stereotopy head waving duration, day 30.40.40.80.80.3-0.50.6-0.7-0.70.70.9-0.90.6
Locomotion velocity, session 70.70.71.20.70.9-0.60.9-0.7-0.71.01.0-1.01.1
Locomotion distance, session 70.00.10.2-0.40.2-0.20.1-0.20.40.3-0.20.20.2
Stereotopy head waving bouts, day 70.20.30.70.80.40.20.3-0.4-0.70.30.6-0.60.4
Stereotopy head waving duration, day 71.41.73.41.51.20.81.0-1.2-1.80.91.6-1.61.0
Locomotion velocity, session 80.50.61.00.90.70.80.7-0.6-1.00.60.9-0.90.5
Locomotion distance, session 80.10.21.1-1.0-0.40.1-0.50.20.3-0.5-0.30.3-0.4
Degree of sensitization distance0.20.20.30.40.50.50.4-0.5-0.40.40.4-0.40.4
Degree of sensitization stereotypy0.20.30.60.80.50.60.3-0.3-0.70.20.5-0.50.3
Conditioned locomotion1.82.13.9-1.4-1.5-2.0-1.21.71.6-1.1-1.41.4-0.9
Cocaine response after cond. corrected0.10.10.30.00.5-0.10.6-0.3-0.00.60.1-0.10.6
Cocaine response after cond. not corrected0.60.61.10.61.00.41.0-0.8-0.61.00.6-0.61.0
Cocaine response before conditioning0.81.01.71.31.00.70.8-1.1-1.10.81.0-1.00.9
Saline control response2.43.26.32.51.91.91.7-1.8-1.91.41.5-1.51.5
Bone: connectivity density0.30.51.21.10.90.60.9-0.50.10.9-0.10.10.8
Bone: cortical apparent density1.41.92.8-1.4-1.7-1.1-1.61.61.1-1.5-1.11.0-1.5
Bone: cortical area0.20.21.80.50.31.30.10.1-0.1-0.1-0.30.4-0.2
Bone: cortical porosity0.20.20.90.10.3-0.90.3-0.10.20.40.1-0.10.7
Bone: cortical porosity0.20.21.3-0.10.2-1.20.30.10.20.40.1-0.10.7
Bone: cortical thickness2.13.54.5-1.6-1.9-0.4-2.02.11.9-2.1-2.12.1-1.9
Bone: cortical thickness0.10.10.3-0.6-0.2-0.2-0.2-0.10.2-0.2-0.10.1-0.2
Bone: cortical tissue density1.41.82.7-1.4-1.6-1.1-1.61.51.0-1.5-1.01.0-1.4
Condit. Reinf. active minus inactive responses0.10.20.9-0.6-0.3-0.9-0.30.1-0.0-0.20.2-0.30.0
Condit. Reinf. active-inactive response ratio0.60.71.30.20.7-0.20.7-1.0-0.90.91.1-1.20.9
Condit. Reinf. active responses0.10.20.4-0.6-0.4-0.6-0.50.50.2-0.4-0.20.1-0.3
Condit. Reinf. inactive responses0.91.11.6-0.8-1.0-0.0-1.01.31.0-1.2-1.21.2-1.1
Incentive salience index mean0.10.10.4-0.6-0.2-0.5-0.40.10.1-0.2-0.0-0.0-0.1
Condit. Reinf. lever presses0.20.20.6-0.7-0.3-0.3-0.40.50.6-0.4-0.50.5-0.2
Condit. Reinf. active minus inactive responses1.11.35.51.30.92.30.7-1.2-1.30.40.8-0.80.2
Condit. Reinf. active-inactive response ratio2.72.83.71.91.71.81.6-1.8-1.91.41.6-1.61.2
Condit. Reinf. active responses0.71.04.91.10.62.20.3-0.9-1.20.10.6-0.6-0.1
Condit. Reinf. inactive responses0.50.61.7-0.1-0.61.3-0.90.30.1-1.1-0.60.6-1.1
Condit. Reinf. lever presses0.50.63.90.70.22.0-0.1-0.6-0.9-0.30.4-0.4-0.5
Condit. Reinf. lever reinforcers received0.50.74.70.80.12.2-0.2-0.5-0.8-0.40.2-0.2-0.7
Conditioned reinforcement - actives0.40.41.11.10.7-0.20.7-0.4-0.40.70.5-0.50.7
Conditioned reinforcement - inactives0.10.20.3-0.2-0.30.1-0.30.50.5-0.5-0.50.6-0.5
Conditioned locomotion0.40.40.90.90.90.00.9-0.6-0.20.80.3-0.30.8
Patch foraging indifference point 0 sec0.20.32.20.1-0.01.5-0.2-0.1-0.1-0.4-0.30.3-0.6
Patch foraging indifference point AUC0.20.30.8-0.8-0.30.9-0.5-0.1-0.4-0.50.1-0.2-0.7
Delay disc. indifference point, 0s delay1.01.11.5-1.1-1.1-0.4-1.20.81.1-1.2-1.11.1-1.2
Delay disc. indifference point, 16s delay3.23.25.0-2.1-2.0-2.2-2.01.81.9-1.7-1.41.4-1.3
Delay disc. indifference point, 2s delay0.10.20.80.40.40.90.2-0.6-0.30.10.0-0.0-0.0
Delay disc. indifference point, 24s delay1.51.42.5-1.5-1.1-1.3-1.11.31.6-1.0-1.21.2-0.7
Delay disc. indifference point, 4s delay0.10.10.70.20.20.8-0.1-0.3-0.1-0.2-0.10.1-0.1
Delay disc. indifference point, 8s delay0.10.10.5-0.1-0.00.7-0.3-0.10.0-0.3-0.20.2-0.3
Indifference point function ln k0.60.81.71.31.10.61.1-0.9-0.51.00.4-0.41.0
Indifference point function log k0.60.81.71.31.10.61.1-0.9-0.51.00.4-0.41.0
Patch foraging total patch changes 0 sec0.20.41.90.1-0.21.4-0.40.20.2-0.6-0.60.6-0.8
Patch foraging total patch changes 12 sec1.31.73.3-1.2-1.11.7-1.50.60.6-1.6-1.11.2-1.8
Patch foraging total patch changes 18 sec0.20.20.70.40.40.90.3-0.5-0.70.30.5-0.50.2
Patch foraging total patch changes 24 sec0.10.20.3-0.4-0.40.0-0.40.60.4-0.4-0.40.4-0.5
Patch foraging total patch changes 6 sec0.40.61.3-1.2-0.90.3-0.90.60.4-0.8-0.60.5-1.1
Patch foraging time to switch 0 sec0.60.96.4-0.4-0.1-2.50.40.00.10.80.7-0.71.0
Patch foraging water rate 0 sec0.81.47.51.41.02.70.6-0.9-1.20.20.5-0.4-0.0
Patch foraging water rate 12 sec0.60.96.81.00.42.6-0.1-0.3-0.5-0.5-0.40.4-0.6
Patch foraging water rate 18 sec0.20.32.40.50.31.50.0-0.2-0.3-0.2-0.10.1-0.3
Patch foraging water rate 24 sec0.10.21.10.4-0.01.1-0.1-0.0-0.0-0.3-0.30.4-0.3
Patch foraging water rate 6 sec0.60.92.21.51.21.51.0-0.8-0.70.70.4-0.30.8
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.6-0.10.7-0.3-0.1-0.3-0.4-0.10.1-0.4
Distance traveled before self-admin0.91.01.71.20.91.30.8-0.9-1.30.70.9-0.90.6
Distance traveled after self-admin2.12.44.32.11.81.11.7-1.5-1.41.51.4-1.31.5
Extensor digitorum longus weight1.66.38.72.62.72.62.3-2.9-2.82.12.5-2.41.9
Bone: elastic displacement0.60.62.20.90.71.50.3-1.0-1.00.10.6-0.60.2
Bone: elastic work0.91.24.71.01.12.20.7-1.4-1.00.50.6-0.60.4
Bone: endosteal estimation5.311.514.53.33.82.03.8-3.6-3.43.73.4-3.43.3
Bone: endosteal perimeter2.55.27.52.72.71.82.7-2.3-1.92.51.8-1.82.3
Epididymis fat weight1.84.25.8-1.5-2.3-0.6-2.32.21.8-2.4-2.12.1-2.4
Delta time in closed arm before/after self-admin0.10.10.20.10.2-0.20.3-0.3-0.10.40.3-0.30.3
Delta time in open arm before/after self-admin0.50.40.7-0.6-0.8-0.8-0.50.80.8-0.5-0.60.6-0.5
Diff in mean of infusions in LGA sessions3.64.04.91.92.10.62.2-2.0-2.02.22.2-2.22.0
Delay discount exponential model param0.30.30.40.60.40.10.7-0.4-0.60.60.6-0.60.4
Extinction: sum of active levers before priming0.20.21.0-0.1-0.4-1.0-0.10.40.4-0.0-0.00.00.0
Active lever presses in extinction session 60.10.10.8-0.2-0.0-0.90.00.10.20.10.1-0.10.4
Bone: final force0.20.30.8-0.5-0.20.9-0.50.30.3-0.6-0.60.6-0.6
Bone: final moment0.20.30.5-0.4-0.30.7-0.40.40.4-0.6-0.70.7-0.5
Food consumed during 24 hour testing period5.16.18.52.42.62.22.3-2.8-2.92.22.7-2.72.0
Glucose1.01.52.71.61.0-0.71.3-1.0-0.91.41.2-1.21.4
Heart weight0.50.72.51.60.70.70.6-0.8-1.00.40.7-0.70.5
Delay discount hyperbolic model param0.20.20.30.40.3-0.10.5-0.2-0.50.50.5-0.50.4
Intermittent access intake day 1-15 change0.60.50.7-0.5-0.7-0.5-0.80.80.9-0.8-0.80.9-0.6
Intermittent access intake escalation0.20.20.6-0.3-0.4-0.8-0.40.40.5-0.3-0.30.4-0.1
Intermittent access intake escalation 20.10.10.2-0.3-0.2-0.4-0.30.30.4-0.3-0.30.30.0
Intermitt. access day 1 inactive lever presses0.60.63.90.40.02.0-0.3-0.2-0.2-0.6-0.50.5-0.9
Intermitt. access day 15 inactive lever presses0.10.10.30.1-0.30.3-0.30.2-0.1-0.4-0.20.2-0.5
Intermitt. access escalation Index0.50.41.11.01.00.30.7-0.5-0.30.60.3-0.30.9
Intermittent access day 1 total infusions0.10.20.50.40.2-0.70.50.10.20.50.2-0.10.5
Intermittent access day 15 total infusions0.40.52.50.40.2-1.60.50.20.40.60.2-0.21.0
Intermittent access terminal intake (last 3 days)1.21.33.11.21.1-1.01.4-0.6-0.51.41.0-0.91.8
Intermittent access total infusions0.40.51.00.80.7-0.60.9-0.3-0.20.90.6-0.51.0
Intermittent access day 1 locomotion0.10.10.50.2-0.0-0.50.20.50.70.2-0.40.40.2
Intermittent access day 15 total locomotion0.20.20.70.2-0.3-0.8-0.00.50.7-0.0-0.30.3-0.2
Intermittent access total locomotion0.20.20.90.90.40.60.5-0.10.10.3-0.10.10.1
Intermittent access standard deviation0.00.00.10.0-0.1-0.2-0.00.20.2-0.0-0.10.10.1
Left kidney weight1.02.710.62.01.63.31.0-2.0-1.60.80.9-0.90.4
Right kidney weight2.36.511.83.12.73.42.2-2.9-2.81.92.1-2.11.7
Cocaine induced anxiety0.91.01.90.71.0-0.51.3-0.7-0.61.40.9-1.01.4
Post-drug Anxiety0.00.00.2-0.4-0.1-0.30.10.20.10.2-0.00.00.1
Baseline Anxiety2.93.15.6-1.9-1.80.6-2.21.31.2-2.2-1.61.6-2.4
Tail length0.41.21.8-1.3-0.90.8-1.20.90.9-1.3-1.41.3-1.0
Length with tail0.20.96.80.30.62.60.1-0.9-0.9-0.10.1-0.1-0.2
Length without tail2.24.78.62.12.22.91.8-2.6-2.71.52.1-2.11.1
Times rat made contact with spout0.50.63.70.50.31.9-0.1-0.5-0.8-0.40.3-0.2-0.5
Lifetime Intake0.30.30.90.60.4-0.90.7-0.00.10.70.3-0.20.8
Liver weight, left0.10.10.40.50.20.60.0-0.3-0.4-0.00.2-0.20.0
Liver weight, right0.10.10.50.40.00.70.0-0.2-0.5-0.10.4-0.4-0.2
Locomotor activity0.10.10.90.20.30.90.1-0.4-0.4-0.00.3-0.3-0.1
Locomotor testing distance0.10.21.20.50.51.10.2-0.3-0.40.00.1-0.1-0.0
Locomotor testing rearing0.20.41.71.30.60.90.6-0.1-0.40.30.1-0.10.4
Locomotion in novel chamber1.51.83.0-1.6-1.6-1.7-1.41.51.4-1.1-1.01.0-1.0
Locomotion in novel chamber post-restriction0.10.20.40.40.60.20.4-0.4-0.30.40.3-0.30.7
Fecal boli incidents, locomotor time 11.21.32.40.91.2-0.31.3-1.0-0.91.41.3-1.31.5
Change in fecal boli incidents, locomotor task0.60.61.7-0.8-0.71.1-0.80.2-0.0-0.9-0.40.3-1.3
Time >=10cm from walls, locomotor time 11.61.62.71.41.3-0.11.4-1.1-1.11.41.3-1.31.6
Bouts of movement, locomotor time 17.27.810.3-3.0-3.0-1.5-3.23.02.7-3.0-2.72.7-2.7
Total resting periods, locomotor time 16.36.99.1-2.8-2.8-1.2-3.02.82.6-2.9-2.62.6-2.6
Rest time, locomotor task time 11.51.62.2-1.1-1.5-0.9-1.51.31.2-1.4-1.31.2-1.2
Distance moved, locomotor task time 10.10.10.10.40.3-0.10.3-0.10.10.40.1-0.00.3
Vertical activity count, locomotor time 10.10.10.40.00.0-0.60.2-0.10.10.40.2-0.20.2
Time >=10cm from walls, locomotor time 20.10.10.5-0.2-0.1-0.70.10.20.10.10.2-0.20.2
Bouts of movement, locomotor time 24.75.16.3-2.2-2.4-1.4-2.52.52.4-2.3-2.32.3-2.0
Total resting periods, locomotor time 24.64.96.1-2.1-2.4-1.4-2.42.52.3-2.3-2.32.3-1.9
Rest time, locomotor task time 23.64.25.5-2.0-2.3-1.9-2.22.32.1-2.0-1.91.9-1.6
Distance moved, locomotor task time 20.10.11.10.20.21.00.1-0.20.1-0.1-0.20.2-0.4
Vertical activity count, locomotor time 20.60.71.10.71.00.51.1-1.0-0.51.00.7-0.70.8
Light reinforcement 10.20.31.1-0.3-0.5-1.0-0.50.70.5-0.5-0.40.4-0.2
Light reinforcement 20.10.10.20.00.20.00.1-0.2-0.50.20.5-0.50.2
Bone: marrow area5.411.614.63.33.82.13.8-3.6-3.43.73.4-3.43.4
Bone: maximum diameter3.15.78.12.82.62.82.4-2.4-2.62.12.1-2.01.8
Bone: maximum force0.10.21.30.10.61.10.4-0.4-0.30.30.0-0.00.3
Bone: maximum moment0.10.20.90.20.61.00.4-0.3-0.30.30.1-0.00.4
Mean time between licks in bursts0.10.20.4-0.6-0.5-0.3-0.50.10.4-0.5-0.30.3-0.4
Mean num. licks in bursts0.50.61.1-0.7-0.31.0-0.60.50.8-0.7-1.01.0-0.8
Cd content in liver0.20.21.00.2-0.0-1.00.10.0-0.60.20.6-0.70.4
Co content in liver2.32.73.4-1.5-1.7-0.6-1.81.91.6-1.8-1.71.7-1.7
Cu content in liver0.40.50.9-0.5-0.40.1-0.40.90.9-0.5-1.01.0-0.5
Fe content in liver0.70.81.2-0.6-0.70.6-0.90.90.9-1.0-1.11.1-1.0
K content in liver0.30.32.00.10.51.40.2-0.40.1-0.1-0.40.4-0.2
Mg content in liver0.80.85.60.40.82.40.3-1.0-0.6-0.00.1-0.0-0.3
Mn content in liver0.40.42.10.70.71.50.5-0.60.30.3-0.50.50.1
Na content in liver0.20.20.60.50.60.60.5-0.8-0.00.40.1-0.00.3
Rb content in liver0.20.20.6-0.4-0.40.5-0.50.20.1-0.7-0.40.4-0.8
Se content in liver0.00.10.20.50.30.30.30.1-0.10.1-0.10.10.2
Sr content in liver0.70.71.7-0.8-1.0-1.3-0.80.61.0-0.6-0.70.7-0.4
Zn content in liver0.80.91.31.01.10.41.1-0.8-1.01.00.9-0.91.1
Bone: minimum diameter0.00.10.20.20.30.50.30.1-0.30.20.2-0.20.2
Time in familiar zone, hab. session 10.00.00.1-0.0-0.00.2-0.10.00.2-0.2-0.40.4-0.1
Time in novel zone, hab. session 10.20.20.40.30.3-0.30.4-0.1-0.50.40.6-0.60.4
Total zone transitions, hab. session 13.65.06.5-2.3-2.2-1.0-2.22.32.5-2.3-2.52.6-2.1
Total locomotion distance, hab. session 15.78.210.1-3.2-2.9-1.8-2.83.13.2-2.8-3.03.0-2.6
Locomotion velocity, hab. session 15.78.110.7-3.3-3.0-1.7-2.92.93.1-2.8-3.03.0-2.6
Time in familiar zone, hab. session 20.20.20.7-0.2-0.10.8-0.3-0.10.0-0.5-0.40.4-0.5
Time in novel zone, hab. session 21.41.42.21.11.0-0.61.3-0.8-1.01.51.4-1.41.4
Total zone transitions, hab. session 22.93.85.0-2.2-1.90.1-2.21.71.9-2.2-2.02.1-2.2
Total locomotion distance, hab. session 25.67.410.1-3.2-2.9-1.7-2.92.82.8-2.7-2.72.7-2.6
Locomotion velocity, hab. session 26.48.611.7-3.4-3.1-2.0-3.13.13.1-2.9-2.92.9-2.7
Novel to familiar place preference ratio0.70.71.10.70.90.10.8-0.7-0.90.81.0-1.01.1
Novelty place preference1.51.52.31.11.40.21.2-1.2-1.31.31.4-1.31.5
Time in novel zone, NPP test2.62.63.71.51.80.31.7-1.6-1.71.71.8-1.81.9
Total zone transitions, NPP test2.83.94.8-2.2-1.9-0.3-2.11.82.0-2.2-2.22.2-2.1
Total locomotion distance, NPP test3.04.15.2-2.3-2.1-1.4-2.02.12.3-2.0-2.12.1-1.8
Locomotion velocity, NPP test4.66.58.0-2.7-2.6-1.6-2.62.72.8-2.5-2.72.7-2.3
Intraocular pressure0.40.61.81.00.61.30.5-0.9-1.10.40.6-0.60.3
Delta distance traveled before/after self-admin0.60.61.51.20.9-0.20.9-0.6-0.30.90.5-0.51.0
Delta ambulatory time before/after self-admin1.61.83.41.81.50.11.6-1.1-0.91.51.1-1.11.6
Parametrial fat weight1.32.63.31.71.61.01.6-1.7-1.81.51.6-1.61.8
Pavlov. Cond. lever latency0.10.20.50.20.20.60.2-0.4-0.70.00.5-0.5-0.0
Pavlov. Cond. magazine entry latency0.30.43.4-0.5-0.3-1.8-0.10.10.10.20.3-0.40.3
Pavlov. Cond. change in total contacts0.50.62.7-1.2-0.7-1.7-0.50.50.7-0.3-0.30.2-0.2
Pavlov. Cond. index score0.20.32.1-0.4-0.1-1.50.0-0.00.30.30.1-0.20.4
Pavlov. Cond. latency score0.20.31.6-0.5-0.3-1.3-0.20.20.6-0.0-0.20.20.1
Pavlov. Cond. lever contacts0.20.21.1-0.6-0.2-1.0-0.10.20.50.1-0.10.10.1
Pavlov. Cond. magazine entry number0.30.43.10.60.31.80.00.10.0-0.3-0.50.6-0.3
Pavlov. Cond. intertrial magazine entries0.20.21.00.40.31.00.2-0.4-0.70.10.4-0.4-0.0
Pavlov. Cond. lever-magazine prob. diff.0.30.42.7-0.40.0-1.60.2-0.20.10.50.4-0.40.6
Pavlov. Cond. response bias0.30.42.4-0.5-0.1-1.60.1-0.10.00.40.5-0.50.4
Pavlov. Cond. lever latency1.01.47.2-1.1-0.7-2.7-0.31.01.5-0.0-0.90.80.3
Pavlov. Cond. magazine entry latency1.41.62.3-1.0-1.3-0.2-1.21.41.4-1.3-1.51.5-1.4
Pavlov. Cond. change in total contacts0.60.96.00.7-0.12.5-0.4-0.4-0.6-0.7-0.00.1-1.0
Pavlov. Cond. index score0.40.53.20.6-0.11.8-0.2-0.1-0.5-0.5-0.00.1-0.7
Pavlov. Cond. latency score0.40.53.70.5-0.11.9-0.3-0.1-0.3-0.6-0.20.2-0.9
Pavlov. Cond. lever contacts0.81.15.41.00.52.30.2-0.9-1.4-0.00.7-0.7-0.3
Pavlov. Cond. magazine entry number0.10.10.4-0.10.3-0.60.2-0.3-0.20.30.3-0.30.6
Pavlov. Cond. intertrial magazine entries0.10.20.30.30.50.30.4-0.5-0.40.40.4-0.40.5
Pavlov. Cond. lever-magazine prob. diff.0.40.53.40.4-0.21.8-0.4-0.1-0.3-0.6-0.20.2-0.9
Pavlov. Cond. response bias0.20.32.10.4-0.01.5-0.2-0.2-0.6-0.40.2-0.2-0.6
Time in closed arm before self-admin2.12.33.21.31.60.91.5-1.7-1.81.41.7-1.71.5
Time in closed arm after self-admin0.50.50.80.70.90.90.7-0.9-0.80.60.7-0.70.4
Time in open arm before self-admin0.00.00.10.3-0.1-0.30.00.0-0.10.10.1-0.10.1
Time in open arm after self-admin0.00.00.10.3-0.0-0.20.30.1-0.10.30.2-0.20.1
Bone: periosteal estimation3.06.37.92.62.82.12.8-2.5-2.62.62.3-2.32.3
Bone: periosteal perimeter1.32.23.81.91.92.01.8-1.2-1.11.60.7-0.71.4
Bone: post-yield work1.01.42.10.91.50.91.3-1.1-1.21.31.0-1.01.3
Progressive ratio test 1 active lever presses0.70.71.31.01.0-0.21.1-0.7-0.41.10.7-0.71.1
Progressive ratio test 1 breakpoint1.61.72.61.51.50.01.6-1.1-0.91.61.2-1.21.5
Progressive ratio test 1 inactive lever presses0.30.31.30.80.61.20.6-0.3-0.20.3-0.10.10.0
Progressive ratio test 2 active lever presses0.10.10.40.3-0.0-0.60.20.20.30.2-0.20.20.3
Progressive ratio test 2 breakpoint0.00.00.10.40.10.10.20.10.20.1-0.20.20.1
Progressive ratio test 2 inactive lever presses0.10.10.60.80.30.00.6-0.0-0.00.50.0-0.00.3
Incentive Sensitization - Responses1.31.32.3-0.6-1.10.0-1.11.21.3-1.2-1.51.5-1.1
Incentive Sensitization - Breakpoint1.51.62.5-0.8-1.3-0.2-1.31.31.3-1.3-1.61.6-1.2
Sum of active levers in priming session hrs 5-60.10.10.40.40.4-0.30.4-0.2-0.10.40.3-0.30.6
Progressive ratio0.20.21.40.00.2-1.20.3-0.00.10.40.3-0.30.7
Food seeking constrained by brief footshock0.40.52.50.30.51.60.0-0.9-0.9-0.10.4-0.4-0.4
Seeking ratio, punishment vs. effort0.60.85.1-0.1-0.12.3-0.5-0.4-0.5-0.7-0.20.2-1.2
Retroperitoneal fat weight0.92.95.1-0.7-1.90.3-1.91.71.5-2.1-1.81.8-2.3
Reaction time number correct0.20.21.00.50.61.00.40.00.10.1-0.40.40.3
Reaction time mean minus median0.10.10.7-0.3-0.0-0.80.20.10.00.30.3-0.30.3
Reaction time mean minus median AUC0.30.31.5-0.3-0.1-1.20.10.70.80.2-0.40.40.4
Reaction time num false alarms1.01.32.2-0.9-1.2-0.8-1.01.51.4-1.0-1.31.3-1.0
Reaction time num false alarms AUC0.60.81.4-0.6-0.9-0.2-0.81.21.1-0.9-1.11.1-1.0
Reaction time trials correct on left0.20.21.00.50.61.00.40.00.10.1-0.40.40.3
Reaction time trials on left0.20.21.20.60.61.10.4-0.00.10.2-0.30.40.3
Reaction time mean0.10.10.7-0.2-0.4-0.9-0.20.30.4-0.1-0.20.2-0.1
Reaction time mean AUC0.00.10.4-0.2-0.2-0.7-0.10.10.10.00.0-0.10.0
Median of all reaction times0.30.41.0-0.4-0.7-1.0-0.60.60.7-0.5-0.50.5-0.4
Reaction time omissions0.00.00.1-0.3-0.00.2-0.10.10.2-0.1-0.10.1-0.2
Reaction time false alarm rate0.81.11.7-0.9-1.3-1.0-1.11.31.1-1.0-1.01.0-1.1
Reaction time premature initiation rate0.91.21.91.41.40.71.2-0.8-1.21.11.1-1.11.0
Reaction time premature initiations1.01.42.61.51.61.31.3-0.8-1.11.00.8-0.81.1
Std. dev. reaction times0.10.10.4-0.20.1-0.60.3-0.0-0.00.40.3-0.30.3
Reaction time trials completed0.20.21.20.60.61.10.4-0.00.10.2-0.30.40.3
Reaction time trials AUC0.10.21.00.40.61.00.40.00.10.1-0.30.40.2
Run reversals in cocaine runway, females0.10.10.3-0.4-0.10.5-0.1-0.20.2-0.1-0.10.1-0.3
Run reversals in cocaine runway, males0.30.31.60.0-0.21.3-0.3-0.0-0.0-0.5-0.50.5-0.7
Latency to leave start box in cocaine runway0.10.10.3-0.5-0.00.2-0.2-0.2-0.3-0.10.3-0.3-0.2
Latency to leave start box in cocaine runway, F0.00.00.1-0.4-0.1-0.1-0.2-0.1-0.2-0.10.3-0.30.0
Latency to leave start box in cocaine runway, M0.80.81.4-1.2-0.9-0.1-1.00.70.7-1.0-0.70.7-1.2
Std. dev. time between licks in bursts0.40.42.5-0.3-0.01.6-0.6-0.20.0-0.7-0.50.5-0.7
Total sessions with >9 infusions0.30.31.11.00.60.70.6-0.2-0.00.4-0.10.10.5
Short access day 1 total inactive lever presses0.50.64.90.40.42.20.1-0.5-0.4-0.2-0.10.1-0.5
Short access day 10 total inactive lever presses0.10.10.60.60.40.80.3-0.2-0.20.1-0.10.10.0
Short access day 1 total infusions0.30.31.30.0-0.3-1.10.00.70.80.1-0.50.50.2
Short access day 10 total infusions2.32.64.01.91.80.72.0-1.5-1.31.91.5-1.41.7
Short access total infusions0.10.20.50.40.2-0.70.40.30.40.4-0.10.10.5
Short access day 1 locomotion0.50.61.51.00.8-0.41.0-0.4-0.11.00.5-0.41.2
Short access day 10 total locomotion0.50.52.31.50.61.40.6-0.2-0.10.3-0.20.20.2
Short access total locomotion0.30.31.11.00.60.40.7-0.20.00.6-0.00.00.6
One hour access (0.3 mA shock)0.60.62.7-0.4-0.7-1.6-0.41.01.0-0.4-0.60.6-0.1
Compulsive drug intake0.60.61.0-0.7-0.8-0.6-0.60.91.0-0.6-0.90.9-0.5
One hour access (shock baseline)0.30.30.80.30.3-0.90.5-0.3-0.30.60.6-0.60.7
Social response proportion2.62.93.8-1.8-2.0-1.3-1.81.81.7-1.6-1.61.6-1.6
Social responses2.33.03.9-1.1-1.9-0.7-1.92.01.7-2.0-1.81.8-1.6
Social time0.30.40.7-0.3-0.7-0.8-0.60.80.8-0.6-0.60.6-0.4
Soleus weight1.44.29.92.22.43.11.9-2.5-1.81.71.4-1.41.3
Bone: stiffness0.20.20.5-0.7-0.30.1-0.30.50.6-0.3-0.60.6-0.3
Tibialis anterior weight4.214.218.34.14.03.43.7-4.3-4.13.53.7-3.63.1
Time to tail flick, vehicle, before self-admin0.30.30.80.40.4-0.90.5-0.1-0.10.60.4-0.40.7
Time to tail flick, vehicle, after self-admin3.53.85.11.72.00.82.0-1.9-2.22.02.3-2.31.9
Time to tail flick, test, before self-admin1.31.21.61.01.31.31.1-1.2-1.11.01.0-1.00.9
Time to tail flick, test, after self-admin0.10.20.3-0.10.30.00.2-0.6-0.50.20.6-0.60.4
Delta time to tail flick, vehicle, before/after SA1.41.42.10.91.11.11.1-1.3-1.41.01.3-1.30.9
Delta time to tail flick, test, before/after SA0.10.10.10.30.2-0.30.2-0.3-0.40.30.4-0.40.4
Tibia length0.82.33.31.21.61.11.6-1.8-1.71.61.5-1.51.4
Ambulatory time before self-admin0.10.10.40.50.30.60.3-0.3-0.30.20.2-0.20.2
Ambulatory time after self-admin1.92.13.61.91.61.11.6-1.4-1.41.41.3-1.31.4
Bone: tissue strength1.81.82.3-1.1-1.5-0.5-1.51.51.3-1.4-1.41.4-1.4
Total heroin consumption0.50.61.20.70.8-0.21.0-0.6-0.51.00.7-0.71.1
Bone: trabecular number0.10.20.80.40.40.90.3-0.30.30.2-0.50.50.1
Bone: trabecular spacing3.95.06.8-2.3-2.6-1.3-2.62.42.0-2.6-2.02.0-2.4
Bone: trabecular thickness0.40.42.00.80.81.40.6-0.6-0.10.3-0.30.30.4
Bone: trabecular tissue density0.30.50.80.70.7-0.10.6-0.4-0.70.60.8-0.80.9
Water consumed over 24 hours2.02.45.01.41.62.21.1-1.8-2.00.91.5-1.50.9
Number of responses in last shaping day9.09.312.43.33.20.73.5-3.0-2.83.53.0-3.03.4