Hub : Genes

Gc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Gc	0.04	0.03	6.4e-04	0.02	0.04	0.03	0.03	1.2e-02	4.3e-04	1.6e-03	1.6e-03
2	Liver	gene expression	Gc	0.06	0.03	9.9e-09	0.06	0.06	0.04	0.06	9.0e-07	1.9e-07	9.1e-06	1.6e-07
3	Liver	mRNA stability	Gc	0.53	0.1	0.0e+00	0.44	0.43	0.46	0.46	7.1e-53	2.2e-52	9.6e-57	1.3e-56

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.6	3.0	4.3	-2.1	1.8	1.3
Area under the delay curve	1.2	1.8	4.8	-0.0	-0.8	2.2
BMI with tail	2.5	8.8	18.8	-4.3	2.5	1.1
BMI without tail	0.6	3.3	5.9	-2.4	2.0	0.3
Body weight	0.1	0.4	1.2	-0.1	-0.2	1.1
Weight adjusted by age	0.2	0.6	1.0	-0.9	1.0	0.3
Bone surface	0.4	0.8	1.6	-0.9	1.3	-0.1
Bone volume	0.2	0.3	0.5	-0.7	0.5	0.4
Breakpoint value in progressive ratio session	0.2	0.3	0.8	0.0	0.0	-0.9
Number of licking bursts	0.1	0.2	0.7	0.0	0.8	0.0
Context. condit. distance diff. score	1.4	1.7	3.1	0.6	-1.8	-1.3
Locomotion velocity, session 1	1.8	2.0	3.6	-1.5	0.7	1.9
Locomotion distance, session 1	0.5	0.6	0.8	-0.5	-0.8	0.9
Locomotion velocity, session 2	0.9	1.1	3.1	-0.4	-0.4	1.8
Locomotion distance, session 2	0.5	0.7	1.6	-0.1	-0.8	1.3
Locomotion velocity, session 3	0.6	0.7	2.0	-0.3	-0.4	1.4
Locomotion distance, session 3	3.4	3.9	6.9	-1.9	1.1	2.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.5	-0.3	-0.4
Stereotopy head waving duration, day 3	0.7	0.8	0.9	0.9	-0.9	-0.9
Locomotion velocity, session 7	0.5	0.6	1.3	0.6	-1.2	0.1
Locomotion distance, session 7	0.6	0.7	1.8	-0.5	-0.2	1.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.1	-0.6	1.0	-0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.5	0.6	0.0
Locomotion velocity, session 8	0.7	0.8	1.8	-1.4	-0.0	0.8
Locomotion distance, session 8	0.4	0.6	1.6	-0.2	-1.3	-0.1
Degree of sensitization distance	2.2	2.4	2.7	1.6	-1.4	-1.6
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.3	0.7	-0.2
Conditioned locomotion	0.6	0.6	1.6	-0.5	-0.2	1.3
Cocaine response after cond. corrected	0.4	0.6	1.0	1.0	-0.8	-0.2
Cocaine response after cond. not corrected	0.3	0.5	0.9	0.6	-0.4	-0.9
Cocaine response before conditioning	1.1	1.3	1.7	-1.1	1.3	-1.0
Saline control response	0.1	0.2	0.4	0.1	-0.6	0.2
Bone: connectivity density	2.3	3.7	5.5	-2.4	2.1	1.1
Bone: cortical apparent density	1.3	2.0	3.4	-1.2	1.1	1.8
Bone: cortical area	0.6	1.0	3.0	0.0	-0.2	-1.7
Bone: cortical porosity	0.6	0.6	1.1	-0.8	1.1	0.3
Bone: cortical porosity	1.0	1.1	2.3	-1.0	1.5	-0.1
Bone: cortical thickness	1.2	2.0	2.3	-1.5	1.3	-1.4
Bone: cortical thickness	1.2	1.4	3.7	0.7	-0.4	-1.9
Bone: cortical tissue density	1.4	2.2	3.8	-1.2	1.2	1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	0.5	0.1
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.6	0.0	1.1	-1.2
Condit. Reinf. active responses	0.3	0.3	1.0	0.0	0.1	1.0
Condit. Reinf. inactive responses	0.7	0.9	2.5	-0.2	-0.4	1.6
Incentive salience index mean	0.1	0.1	0.2	-0.2	0.4	0.4
Condit. Reinf. lever presses	0.4	0.6	0.7	-0.8	0.6	0.8
Condit. Reinf. active minus inactive responses	0.8	1.3	3.5	-0.6	-0.3	1.9
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	0.1	-0.1	0.4
Condit. Reinf. active responses	1.1	1.6	4.2	-0.1	-0.8	2.1
Condit. Reinf. inactive responses	0.6	0.9	2.0	0.0	-0.9	1.4
Condit. Reinf. lever presses	1.7	2.4	4.2	1.7	-2.1	0.4
Condit. Reinf. lever reinforcers received	1.1	1.6	4.0	-0.1	-0.9	2.0
Conditioned reinforcement - actives	0.1	0.3	0.4	0.5	-0.6	0.5
Conditioned reinforcement - inactives	0.5	1.4	2.0	1.4	-1.3	-0.8
Conditioned locomotion	1.3	1.9	2.9	1.7	-1.2	1.1
Patch foraging indifference point 0 sec	0.2	0.5	1.1	-0.5	-0.1	1.1
Patch foraging indifference point AUC	0.3	0.8	1.2	1.1	-0.8	0.7
Delay disc. indifference point, 0s delay	0.7	0.7	1.9	0.1	-0.6	1.4
Delay disc. indifference point, 16s delay	0.7	1.0	2.5	-0.6	-0.2	1.6
Delay disc. indifference point, 2s delay	2.2	2.5	3.7	1.1	-1.9	1.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.4	-0.4	0.6
Delay disc. indifference point, 4s delay	2.0	2.1	5.3	0.3	-1.0	2.3
Delay disc. indifference point, 8s delay	1.1	1.9	3.9	-1.1	0.7	2.0
Indifference point function ln k	0.2	0.7	1.9	-0.2	0.2	-1.4
Indifference point function log k	0.2	0.7	1.9	-0.2	0.2	-1.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.3	-0.2	0.7
Patch foraging total patch changes 12 sec	0.6	0.9	2.5	-0.1	-0.3	1.6
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.1	0.3	0.3
Patch foraging total patch changes 24 sec	0.2	0.6	0.9	0.2	-0.9	1.0
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	0.3	-0.7	1.2
Patch foraging time to switch 0 sec	0.8	3.2	5.5	-1.9	2.3	0.7
Patch foraging water rate 0 sec	0.5	1.7	2.8	1.7	-1.5	-0.4
Patch foraging water rate 12 sec	0.1	0.5	0.8	0.6	-0.9	-0.5
Patch foraging water rate 18 sec	0.3	0.6	1.2	0.8	-1.1	0.3
Patch foraging water rate 24 sec	0.8	1.1	2.2	1.5	-1.0	-0.5
Patch foraging water rate 6 sec	1.3	1.9	3.0	1.5	-1.7	-0.5
Seeking ratio, delayed vs. immediate footshock	1.0	1.4	2.4	1.1	-1.6	-0.8
Distance traveled before self-admin	0.1	0.2	0.3	0.6	-0.2	-0.3
Distance traveled after self-admin	3.1	5.4	9.2	3.0	-2.3	-1.4
Extensor digitorum longus weight	11.0	43.8	67.7	-8.0	8.2	0.5
Bone: elastic displacement	0.6	0.8	0.8	-0.8	0.9	-0.9
Bone: elastic work	1.4	1.9	3.2	-1.6	1.8	-0.3
Bone: endosteal estimation	1.9	4.7	7.0	2.6	-2.5	-1.0
Bone: endosteal perimeter	0.5	1.3	2.4	1.5	-1.0	-0.7
Epididymis fat weight	0.3	1.4	4.1	-0.1	-0.3	2.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.8	-0.1	0.5
Delta time in open arm before/after self-admin	0.4	0.5	1.5	0.2	-0.3	1.2
Diff in mean of infusions in LGA sessions	1.0	1.8	4.9	0.3	0.6	-2.2
Delay discount exponential model param	1.3	1.8	4.4	-0.2	0.9	-2.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.0	-0.2	-0.2
Active lever presses in extinction session 6	1.1	1.1	2.1	1.4	-1.0	-0.4
Bone: final force	0.1	0.2	0.2	0.5	-0.1	-0.5
Bone: final moment	0.1	0.2	0.5	0.7	-0.2	-0.3
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.5	0.0	0.7
Glucose	0.9	1.5	2.6	1.6	-1.3	-0.2
Heart weight	0.4	0.7	1.7	-0.4	0.5	-1.3
Delay discount hyperbolic model param	1.5	1.9	4.6	-0.2	1.1	-2.1
Intermittent access intake day 1-15 change	0.3	1.4	3.9	-0.4	0.4	2.0
Intermittent access intake escalation	0.3	1.4	3.6	-0.5	0.7	1.9
Intermittent access intake escalation 2	1.0	1.6	1.9	1.3	-1.1	1.4
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.7	-0.3	-0.8	0.6
Intermitt. access day 15 inactive lever presses	0.5	2.5	3.5	1.6	-1.2	-1.9
Intermitt. access escalation Index	0.7	2.2	3.4	-0.4	1.7	-1.8
Intermittent access day 1 total infusions	0.3	0.9	1.3	1.0	-1.1	-0.5
Intermittent access day 15 total infusions	0.4	0.9	1.5	1.2	-1.0	0.3
Intermittent access terminal intake (last 3 days)	1.7	2.9	4.7	2.2	-2.0	0.1
Intermittent access total infusions	1.3	1.6	2.7	1.4	-1.6	-0.2
Intermittent access day 1 locomotion	0.2	0.4	0.8	0.6	-0.9	-0.2
Intermittent access day 15 total locomotion	0.8	3.2	5.1	2.1	-2.2	-0.4
Intermittent access total locomotion	1.1	1.3	1.9	1.4	-1.4	0.3
Intermittent access standard deviation	0.1	0.5	0.6	0.6	-0.7	0.7
Left kidney weight	0.0	0.4	0.6	0.6	-0.8	-0.4
Right kidney weight	0.3	1.9	2.7	1.7	-1.4	-1.0
Cocaine induced anxiety	0.3	0.7	1.1	0.1	1.1	-1.0
Post-drug Anxiety	0.2	0.3	0.6	-0.2	0.8	-0.4
Baseline Anxiety	0.1	0.2	0.4	-0.1	-0.7	-0.3
Tail length	1.1	5.8	13.0	3.6	-2.1	0.0
Length with tail	2.4	10.5	23.0	4.8	-2.9	-0.4
Length without tail	0.6	3.1	5.3	2.3	-2.0	0.3
Times rat made contact with spout	1.4	1.6	2.6	-1.6	1.4	0.3
Lifetime Intake	0.5	0.6	0.9	0.6	-1.0	0.7
Liver weight, left	1.2	2.1	4.2	0.6	-1.4	2.1
Liver weight, right	0.8	1.3	3.3	0.0	-0.8	1.8
Locomotor activity	1.0	1.5	2.7	0.7	-1.7	1.1
Locomotor testing distance	0.2	0.5	1.0	0.5	-1.0	-0.6
Locomotor testing rearing	0.1	0.4	0.6	0.6	-0.8	-0.6
Locomotion in novel chamber	0.1	0.1	0.2	0.0	-0.5	0.4
Locomotion in novel chamber post-restriction	0.2	0.7	1.4	0.7	-0.4	1.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.1	0.2	0.4
Change in fecal boli incidents, locomotor task	0.4	0.5	1.0	-0.1	1.0	-0.6
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.6	-0.2	1.3	0.4
Bouts of movement, locomotor time 1	0.9	1.2	2.7	0.8	-0.4	-1.6
Total resting periods, locomotor time 1	0.9	1.1	2.2	0.9	-0.3	-1.5
Rest time, locomotor task time 1	1.8	2.9	4.3	1.9	-0.7	-2.1
Distance moved, locomotor task time 1	0.6	1.6	2.8	-1.3	0.4	1.7
Vertical activity count, locomotor time 1	0.1	1.0	2.7	-0.5	0.1	1.7
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.7	-0.4	1.3	0.1
Bouts of movement, locomotor time 2	0.3	1.0	1.5	0.9	-1.2	-0.8
Total resting periods, locomotor time 2	0.2	0.9	1.2	0.9	-1.1	-0.9
Rest time, locomotor task time 2	1.7	2.9	4.9	1.7	-0.9	-2.2
Distance moved, locomotor task time 2	2.2	3.0	3.8	-2.0	1.3	1.8
Vertical activity count, locomotor time 2	1.0	2.4	6.1	-0.9	0.5	2.5
Light reinforcement 1	0.2	0.8	1.4	0.2	-0.9	1.2
Light reinforcement 2	0.4	0.9	1.9	-0.8	-0.1	1.4
Bone: marrow area	1.8	4.5	6.7	2.6	-2.4	-1.0
Bone: maximum diameter	0.5	0.9	2.7	0.4	-0.1	-1.6
Bone: maximum force	0.2	0.4	0.7	0.7	-0.3	-0.8
Bone: maximum moment	0.3	0.6	0.9	1.0	-0.5	-0.8
Mean time between licks in bursts	0.0	0.0	0.1	0.2	0.3	-0.2
Mean num. licks in bursts	0.1	0.2	0.5	-0.7	-0.3	0.3
Cd content in liver	2.8	3.1	4.1	-1.2	1.9	-2.0
Co content in liver	1.5	1.7	2.5	1.3	-1.0	-1.6
Cu content in liver	0.7	0.8	1.5	1.0	-1.2	0.1
Fe content in liver	1.0	1.2	2.3	-0.4	1.0	1.5
K content in liver	1.6	1.5	3.8	-0.5	-0.7	1.9
Mg content in liver	1.3	1.5	3.4	-0.0	-1.0	1.9
Mn content in liver	0.7	0.8	1.2	-1.0	0.5	1.1
Na content in liver	0.7	0.8	2.4	-0.2	-0.0	1.5
Rb content in liver	0.1	0.1	0.2	0.1	0.4	-0.3
Se content in liver	1.1	1.3	3.0	0.0	-0.9	1.7
Sr content in liver	3.0	2.6	7.6	0.3	0.2	-2.8
Zn content in liver	0.5	0.6	1.3	-0.3	-0.6	1.2
Bone: minimum diameter	6.0	11.5	17.9	4.2	-3.9	-1.1
Time in familiar zone, hab. session 1	0.7	0.7	1.2	-1.1	0.2	1.0
Time in novel zone, hab. session 1	0.7	0.8	2.0	1.4	-0.5	-0.4
Total zone transitions, hab. session 1	1.2	1.7	3.8	0.0	-1.1	1.9
Total locomotion distance, hab. session 1	1.9	2.6	5.8	1.3	-2.4	0.8
Locomotion velocity, hab. session 1	1.0	1.4	3.4	0.7	-1.8	0.6
Time in familiar zone, hab. session 2	0.6	0.6	1.0	-0.9	1.0	0.3
Time in novel zone, hab. session 2	0.8	0.9	1.3	1.1	-1.0	-0.7
Total zone transitions, hab. session 2	0.7	0.9	2.1	0.4	-0.8	-1.4
Total locomotion distance, hab. session 2	2.2	2.9	3.9	1.4	-1.7	-2.0
Locomotion velocity, hab. session 2	1.6	2.1	2.9	1.2	-1.7	-1.4
Novel to familiar place preference ratio	0.2	0.3	0.6	0.2	-0.4	0.8
Novelty place preference	0.3	0.4	1.1	0.3	-0.4	1.0
Time in novel zone, NPP test	0.6	0.7	1.6	0.4	-0.5	1.3
Total zone transitions, NPP test	0.1	0.2	0.5	-0.7	0.1	0.2
Total locomotion distance, NPP test	0.1	0.2	0.4	0.1	-0.7	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	-0.2	-0.4	-0.4
Intraocular pressure	0.8	1.2	3.1	-0.1	0.8	1.8
Delta distance traveled before/after self-admin	1.7	1.9	3.3	1.8	-1.4	-0.7
Delta ambulatory time before/after self-admin	0.6	1.0	1.5	1.2	-0.8	-0.8
Parametrial fat weight	0.6	1.3	1.7	1.2	-1.3	0.9
Pavlov. Cond. lever latency	0.6	0.7	1.4	-0.5	1.2	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.5	0.3	0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.0	-0.5	0.3
Pavlov. Cond. index score	0.5	0.6	1.5	-0.4	-0.3	1.2
Pavlov. Cond. latency score	0.3	0.4	0.9	-0.3	-0.4	1.0
Pavlov. Cond. lever contacts	0.4	0.5	0.9	0.3	-0.9	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.7	0.8	-1.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.6	-0.3	-0.4	1.3
Pavlov. Cond. response bias	0.5	0.7	1.7	-0.0	-0.5	1.3
Pavlov. Cond. lever latency	0.2	0.2	0.6	-0.0	0.1	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.7	-0.1	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	-0.2	0.3
Pavlov. Cond. index score	0.1	0.1	0.3	0.6	-0.3	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	-0.0	-0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.5	0.6	-0.7	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	-0.5	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.9	-0.0	-0.3	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.6	-0.4	0.2
Pavlov. Cond. response bias	0.3	0.4	0.5	0.6	-0.5	0.7
Time in closed arm before self-admin	1.3	2.2	3.7	1.4	-1.1	-1.9
Time in closed arm after self-admin	2.5	2.9	3.8	1.3	-1.9	-1.8
Time in open arm before self-admin	0.4	0.5	0.8	-0.6	0.9	0.4
Time in open arm after self-admin	1.4	1.6	4.4	-0.2	0.5	2.1
Bone: periosteal estimation	1.1	2.6	2.8	1.7	-1.6	-1.6
Bone: periosteal perimeter	0.4	0.8	1.6	0.8	-0.5	-1.3
Bone: post-yield work	0.7	1.2	2.3	1.5	-1.1	-0.2
Progressive ratio test 1 active lever presses	1.1	2.0	3.0	1.7	-1.7	0.1
Progressive ratio test 1 breakpoint	1.1	1.9	2.9	1.7	-1.7	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.9	2.3	0.5	-1.5	-0.2
Progressive ratio test 2 active lever presses	1.3	1.8	3.0	1.7	-1.5	0.3
Progressive ratio test 2 breakpoint	1.4	1.8	3.0	1.7	-1.5	0.2
Progressive ratio test 2 inactive lever presses	1.0	3.1	4.8	2.0	-2.2	-0.6
Incentive Sensitization - Responses	0.2	0.5	1.1	1.0	-0.7	-0.1
Incentive Sensitization - Breakpoint	0.3	0.6	1.2	1.1	-0.7	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.7	0.4	0.6
Progressive ratio	0.0	0.1	0.2	-0.4	0.4	-0.2
Food seeking constrained by brief footshock	0.2	0.3	0.4	-0.5	0.7	-0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.5	-0.5	-0.1
Retroperitoneal fat weight	0.2	1.0	1.4	0.9	-0.9	1.2
Reaction time number correct	0.1	0.4	0.6	0.8	-0.6	-0.3
Reaction time mean minus median	0.1	0.7	1.2	-0.1	1.0	1.1
Reaction time mean minus median AUC	0.1	0.4	0.8	0.1	0.6	0.9
Reaction time num false alarms	0.1	0.1	0.2	0.1	-0.5	-0.4
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.1	-0.3	-0.3
Reaction time trials correct on left	0.1	0.4	0.6	0.8	-0.6	-0.3
Reaction time trials on left	0.1	0.4	0.6	0.8	-0.6	-0.3
Reaction time mean	0.1	0.2	0.2	0.4	0.4	-0.4
Reaction time mean AUC	0.1	0.2	0.4	0.6	0.2	-0.5
Median of all reaction times	0.2	0.4	0.7	0.5	0.3	-0.9
Reaction time omissions	0.1	0.2	0.3	-0.3	0.5	0.5
Reaction time false alarm rate	0.0	0.1	0.2	-0.4	-0.1	0.1
Reaction time premature initiation rate	0.5	0.7	1.2	0.8	-1.1	-0.6
Reaction time premature initiations	0.5	1.4	2.3	1.2	-1.5	-0.6
Std. dev. reaction times	0.1	0.2	0.4	0.6	0.4	0.1
Reaction time trials completed	0.1	0.4	0.6	0.8	-0.6	-0.3
Reaction time trials AUC	0.1	0.4	0.7	0.8	-0.5	-0.4
Run reversals in cocaine runway, females	0.6	0.6	1.5	0.5	-1.2	-0.3
Run reversals in cocaine runway, males	0.6	0.6	1.0	-1.0	0.8	0.5
Latency to leave start box in cocaine runway	2.4	3.3	4.7	2.1	-0.9	-2.2
Latency to leave start box in cocaine runway, F	2.8	3.5	5.3	2.3	-1.5	-1.7
Latency to leave start box in cocaine runway, M	1.0	1.0	2.5	0.4	0.4	-1.6
Std. dev. time between licks in bursts	0.4	0.8	2.0	-0.4	0.3	1.4
Total sessions with >9 infusions	0.9	1.1	2.5	-0.8	0.4	1.6
Short access day 1 total inactive lever presses	0.3	0.6	1.5	0.7	-1.2	0.0
Short access day 10 total inactive lever presses	0.2	1.5	3.2	0.5	-1.0	-1.8
Short access day 1 total infusions	0.2	0.4	1.0	0.1	-0.6	1.0
Short access day 10 total infusions	0.5	0.8	1.6	0.2	-0.8	1.3
Short access total infusions	0.6	0.9	2.3	-0.6	-0.1	1.5
Short access day 1 locomotion	0.5	0.8	2.2	0.4	0.1	1.5
Short access day 10 total locomotion	0.0	0.2	0.5	0.1	-0.7	-0.2
Short access total locomotion	0.2	0.4	1.1	-0.1	-0.1	1.0
One hour access (0.3 mA shock)	2.5	3.0	5.4	2.3	-1.8	0.7
Compulsive drug intake	0.3	0.5	1.1	-1.1	0.5	0.1
One hour access (shock baseline)	0.9	2.3	3.2	1.8	-1.5	1.2
Social response proportion	0.3	0.4	0.8	0.2	-0.9	0.7
Social responses	0.4	0.6	0.9	0.2	-0.8	1.0
Social time	0.5	0.7	1.2	1.0	-1.1	-0.3
Soleus weight	1.7	5.0	10.2	-3.2	2.2	-0.2
Bone: stiffness	0.6	1.1	1.5	1.2	-1.2	0.6
Tibialis anterior weight	3.9	13.6	21.5	-4.6	4.3	0.8
Time to tail flick, vehicle, before self-admin	1.6	2.0	3.5	1.9	-1.5	-0.4
Time to tail flick, vehicle, after self-admin	0.6	1.2	2.0	1.4	-1.2	-0.2
Time to tail flick, test, before self-admin	0.7	0.8	2.2	0.4	0.0	-1.5
Time to tail flick, test, after self-admin	1.7	1.8	3.8	1.9	-1.2	-0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.5	0.2	0.8
Delta time to tail flick, test, before/after SA	0.8	1.0	1.8	0.9	-0.7	1.4
Tibia length	1.6	4.5	5.9	2.4	-2.1	-1.7
Ambulatory time before self-admin	0.1	0.3	0.4	0.7	-0.6	-0.2
Ambulatory time after self-admin	3.5	5.6	8.7	2.9	-2.5	-1.4
Bone: tissue strength	0.4	0.4	0.6	0.8	-0.6	0.4
Total heroin consumption	1.6	1.9	3.1	1.8	-0.3	-1.6
Bone: trabecular number	1.3	2.4	3.2	-1.8	1.4	1.5
Bone: trabecular spacing	0.2	0.4	0.6	0.5	-0.8	-0.4
Bone: trabecular thickness	0.4	0.6	1.0	-0.7	0.5	1.0
Bone: trabecular tissue density	0.0	0.0	0.0	-0.1	0.2	0.0
Water consumed over 24 hours	0.0	0.0	0.1	-0.1	0.1	-0.2
Number of responses in last shaping day	2.5	3.2	6.6	-1.3	1.2	2.6