Gas2l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Gas2l1	0.04	0.03	1.3e-03	0.01	0.02	0.02	0.02	1.4e-02	2.4e-03	3.0e-03	5.3e-03
2	NAcc	alternative polyA	XM_039092217.2	0.03	0.02	9.4e-03	0.02	0.01	0.01	0.01	1.3e-03	7.4e-03	1.3e-02	2.3e-03
3	Brain	alternative polyA	XM_063273391.1	0.06	0.05	5.0e-03	0.04	0.03	0.05	0.04	9.9e-05	1.6e-03	2.9e-05	3.1e-04
4	PL	alternative polyA	NM_001401406.1	0.05	0.04	7.4e-03	0.02	0.02	0.01	0.02	7.1e-03	3.4e-03	9.3e-03	4.2e-03
5	Brain	alternative polyA	NM_001401406.1	0.09	0.09	2.1e-03	0.01	0.03	0.04	0.01	1.3e-02	1.1e-03	2.6e-04	6.2e-02
6	PL	alternative polyA	NM_001401406.1	0.1	0.07	3.3e-04	0.02	0.04	0.03	0.03	5.9e-03	9.7e-05	5.0e-04	6.4e-04
7	PL	alternative polyA	XM_063273391.1	0.09	0.07	1.5e-03	0.02	0.03	0.02	0.02	1.9e-03	2.0e-04	6.5e-03	1.9e-03
8	Adipose	gene expression	Gas2l1	0.04	0.03	1.8e-03	0.02	0.01	0.01	0.01	2.8e-03	3.2e-02	2.3e-02	2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.5	0.1	0.2	-0.5	0.5	0.2	0.5	-0.6	0.7
Area under the delay curve	1.0	1.6	3.9	-2.0	1.6	1.5	0.9	-1.6	0.6	0.1	-0.3
BMI with tail	0.1	0.2	0.4	0.0	-0.3	0.5	-0.5	-0.2	-0.5	0.6	-0.6
BMI without tail	0.2	1.1	2.1	-1.3	1.4	0.1	1.3	-0.5	1.2	-0.9	0.6
Body weight	0.6	2.6	6.5	-2.6	2.2	1.6	1.5	-1.8	1.1	-0.3	-0.1
Weight adjusted by age	0.3	0.9	1.6	-1.1	1.2	0.0	1.3	-0.6	1.2	-0.9	0.8
Bone surface	0.1	0.3	0.9	-0.6	0.6	0.7	0.3	-1.0	0.1	0.1	0.2
Bone volume	0.1	0.2	0.6	-0.5	0.7	0.4	0.5	-0.8	0.3	-0.1	0.4
Breakpoint value in progressive ratio session	0.1	0.3	0.6	-0.8	0.6	0.6	0.3	-0.7	0.2	0.1	-0.3
Number of licking bursts	0.6	1.7	4.0	-2.0	1.8	1.2	1.2	-1.7	0.9	-0.2	0.3
Context. condit. distance diff. score	1.6	2.0	4.8	2.2	-1.8	-1.6	-1.0	1.9	-0.6	-0.1	0.2
Locomotion velocity, session 1	2.3	2.6	4.3	0.7	-1.5	1.1	-2.0	-0.1	-2.1	2.1	-2.0
Locomotion distance, session 1	0.5	0.7	1.6	0.6	-0.1	-1.3	0.4	0.8	0.6	-0.9	1.1
Locomotion velocity, session 2	2.1	2.6	4.5	0.8	-1.5	1.3	-2.0	-0.4	-2.1	2.1	-1.8
Locomotion distance, session 2	1.2	1.7	3.7	1.9	-1.8	-0.7	-1.6	1.1	-1.3	0.8	-0.4
Locomotion velocity, session 3	1.0	1.2	2.7	1.6	-1.1	-1.6	-0.3	1.5	-0.0	-0.6	0.8
Locomotion distance, session 3	0.1	0.1	0.4	-0.1	0.1	0.4	-0.0	-0.7	-0.2	0.2	0.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	0.9	-0.6	-0.9	-0.1	0.9	0.1	-0.5	0.4
Stereotopy head waving duration, day 3	1.0	1.3	2.9	1.7	-1.4	-1.3	-0.8	1.7	-0.5	-0.1	-0.0
Locomotion velocity, session 7	0.1	0.1	0.3	-0.3	0.2	0.5	-0.1	-0.5	-0.2	0.4	-0.1
Locomotion distance, session 7	0.4	0.5	0.9	0.8	-1.0	0.0	-0.9	0.2	-0.9	0.7	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.0	0.1	-0.2	0.2	0.2	0.3	-0.3	0.1
Stereotopy head waving duration, day 7	0.2	0.3	0.5	-0.2	0.4	-0.4	0.6	0.1	0.7	-0.7	0.5
Locomotion velocity, session 8	1.9	2.3	3.9	1.8	-2.0	-0.0	-1.9	0.8	-1.8	1.4	-1.2
Locomotion distance, session 8	3.6	5.3	12.8	3.6	-3.0	-2.5	-1.9	3.0	-1.3	0.1	0.2
Degree of sensitization distance	1.5	1.6	3.2	1.7	-1.8	-0.7	-1.4	1.4	-1.2	0.7	-0.7
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.5	0.5	0.0	0.5	-0.1	0.4	-0.3	0.1
Conditioned locomotion	0.8	1.0	2.2	0.8	-0.3	-1.5	0.5	1.0	0.8	-1.2	1.2
Cocaine response after cond. corrected	0.7	1.1	2.6	-1.6	1.4	0.9	1.0	-1.2	0.7	-0.2	0.2
Cocaine response after cond. not corrected	1.3	1.8	3.8	-1.9	1.9	0.5	1.6	-1.2	1.3	-0.8	0.8
Cocaine response before conditioning	0.3	0.4	1.0	0.4	0.0	-1.0	0.4	0.7	0.5	-0.8	0.8
Saline control response	0.5	0.7	1.5	1.1	-1.2	-0.1	-1.1	0.4	-1.0	0.7	-0.4
Bone: connectivity density	0.1	0.2	0.4	0.3	-0.0	-0.6	0.3	0.3	0.3	-0.5	0.6
Bone: cortical apparent density	0.3	0.4	1.0	-1.0	0.8	0.6	0.6	-0.8	0.4	-0.1	0.1
Bone: cortical area	1.3	2.1	4.6	-2.1	2.0	1.2	1.4	-1.7	1.1	-0.4	0.4
Bone: cortical porosity	0.1	0.1	0.3	-0.3	0.4	-0.1	0.5	-0.1	0.5	-0.4	0.5
Bone: cortical porosity	0.2	0.2	0.4	0.2	0.0	-0.6	0.3	0.5	0.4	-0.6	0.6
Bone: cortical thickness	1.6	2.7	5.1	-2.0	2.3	0.5	2.0	-1.4	1.7	-1.2	1.3
Bone: cortical thickness	1.1	1.4	2.6	0.4	0.3	-1.6	1.0	0.9	1.2	-1.5	1.6
Bone: cortical tissue density	0.3	0.4	1.0	-1.0	0.8	0.7	0.5	-0.9	0.3	0.0	0.0
Condit. Reinf. active minus inactive responses	1.8	2.0	3.5	-0.2	-0.6	1.8	-1.3	-1.2	-1.6	1.9	-1.7
Condit. Reinf. active-inactive response ratio	4.3	4.6	7.6	1.1	-2.1	1.6	-2.6	-0.2	-2.8	2.7	-2.7
Condit. Reinf. active responses	0.8	1.0	2.0	-0.1	-0.4	1.4	-0.9	-1.0	-1.1	1.3	-1.2
Condit. Reinf. inactive responses	0.6	0.8	1.3	-0.7	1.1	0.0	1.2	-0.7	1.0	-0.9	1.0
Incentive salience index mean	1.0	1.2	2.9	-0.6	-0.0	1.7	-0.7	-1.4	-1.0	1.4	-1.2
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.5	0.6	0.5	0.3	-0.8	0.2	-0.0	0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	0.9	-0.9	-0.5	-0.6	0.5	-0.5	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	-0.5	0.1	-0.5	-0.0	-0.5	0.4	-0.2
Condit. Reinf. active responses	0.4	0.6	1.4	1.1	-1.2	-0.4	-0.9	0.6	-0.8	0.5	-0.1
Condit. Reinf. inactive responses	0.5	0.7	1.5	1.2	-1.2	-0.5	-1.0	0.8	-0.8	0.5	-0.3
Condit. Reinf. lever presses	0.2	0.2	0.6	0.8	-0.6	-0.6	-0.3	0.5	-0.2	-0.0	0.5
Condit. Reinf. lever reinforcers received	0.3	0.5	1.1	1.0	-1.0	-0.4	-0.8	0.5	-0.7	0.5	-0.0
Conditioned reinforcement - actives	0.0	0.2	0.5	-0.6	0.7	0.3	0.4	-0.3	0.3	-0.2	-0.2
Conditioned reinforcement - inactives	0.1	0.4	0.8	-0.9	0.7	0.8	0.2	-0.8	0.0	0.3	-0.3
Conditioned locomotion	0.5	0.8	1.8	-1.3	1.4	0.5	1.0	-0.8	0.8	-0.5	0.3
Patch foraging indifference point 0 sec	0.5	1.4	3.4	-1.8	1.8	1.0	1.2	-1.2	0.9	-0.4	0.0
Patch foraging indifference point AUC	0.0	0.1	0.2	-0.1	-0.1	0.3	-0.2	-0.3	-0.3	0.4	-0.2
Delay disc. indifference point, 0s delay	0.8	0.9	2.0	-1.4	1.3	0.5	1.1	-0.8	1.0	-0.6	0.3
Delay disc. indifference point, 16s delay	0.8	1.2	3.0	-1.2	0.6	1.7	-0.2	-1.3	-0.5	1.0	-1.3
Delay disc. indifference point, 2s delay	2.1	2.3	4.0	-1.8	2.0	0.2	2.0	-0.9	1.8	-1.4	1.2
Delay disc. indifference point, 24s delay	0.4	0.7	1.8	-0.9	0.4	1.3	-0.2	-1.1	-0.4	0.8	-0.9
Delay disc. indifference point, 4s delay	2.0	2.1	4.5	-2.1	2.0	0.8	1.6	-1.4	1.4	-0.8	0.6
Delay disc. indifference point, 8s delay	0.3	0.5	1.2	-1.0	0.7	1.1	0.2	-1.0	0.0	0.4	-0.5
Indifference point function ln k	0.1	0.3	0.5	-0.2	0.5	-0.3	0.6	-0.1	0.6	-0.6	0.7
Indifference point function log k	0.1	0.3	0.5	-0.2	0.5	-0.3	0.6	-0.1	0.6	-0.6	0.7
Patch foraging total patch changes 0 sec	0.4	1.3	3.1	-1.8	1.6	1.1	1.0	-1.3	0.7	-0.2	-0.2
Patch foraging total patch changes 12 sec	0.5	0.6	1.7	-1.3	1.1	0.4	0.9	-0.6	0.8	-0.4	0.2
Patch foraging total patch changes 18 sec	0.5	1.3	2.8	-1.0	0.3	1.7	-0.6	-1.1	-0.9	1.3	-1.5
Patch foraging total patch changes 24 sec	0.3	1.2	2.1	1.4	-1.4	-0.7	-1.2	1.3	-1.0	0.5	-0.7
Patch foraging total patch changes 6 sec	0.6	1.1	2.4	-1.5	1.2	1.3	0.6	-1.5	0.3	0.3	-0.2
Patch foraging time to switch 0 sec	0.1	0.3	0.9	0.6	-0.4	-0.9	0.0	1.0	0.2	-0.5	0.3
Patch foraging water rate 0 sec	0.3	1.2	2.9	-1.3	0.9	1.7	0.0	-1.7	-0.4	0.9	-0.7
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.1	0.1	0.4	-0.1	-0.4	-0.2	0.3	-0.1
Patch foraging water rate 18 sec	1.0	2.2	4.1	-0.4	1.2	-1.4	1.7	0.7	1.9	-2.0	1.8
Patch foraging water rate 24 sec	0.3	0.5	0.8	0.2	-0.5	0.6	-0.8	-0.1	-0.9	0.9	-0.9
Patch foraging water rate 6 sec	0.3	0.4	0.9	-0.8	0.9	0.3	0.7	-0.6	0.6	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	0.2	-0.2	-0.3	-0.1	0.5	0.0	-0.1	-0.3
Distance traveled before self-admin	0.7	1.5	2.6	-1.0	1.4	-0.4	1.6	-0.2	1.6	-1.4	1.4
Distance traveled after self-admin	1.1	2.0	3.5	-0.8	1.3	-0.9	1.8	0.1	1.9	-1.8	1.6
Extensor digitorum longus weight	1.7	6.9	15.4	-3.9	3.5	2.6	2.4	-3.4	1.7	-0.5	0.2
Bone: elastic displacement	0.6	0.8	1.5	0.3	0.3	-1.2	0.8	1.0	1.0	-1.2	1.0
Bone: elastic work	1.5	1.9	3.4	-0.8	1.4	-1.0	1.7	0.4	1.8	-1.8	1.4
Bone: endosteal estimation	0.0	0.1	0.2	-0.4	0.4	0.0	0.3	0.0	0.3	-0.2	-0.1
Bone: endosteal perimeter	0.2	0.4	1.1	-1.0	0.7	0.9	0.3	-0.8	0.2	0.2	-0.4
Epididymis fat weight	0.2	1.0	1.7	-1.3	1.3	0.7	1.1	-1.3	0.8	-0.4	0.7
Delta time in closed arm before/after self-admin	4.1	3.8	9.1	2.8	-2.3	-2.6	-1.0	3.0	-0.3	-0.7	0.6
Delta time in open arm before/after self-admin	2.7	3.1	6.7	-2.6	2.0	2.5	0.8	-2.5	0.3	0.6	-1.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.2	-0.1	-0.6	0.1	0.4	0.2	-0.3	0.5
Delay discount exponential model param	1.1	1.5	3.8	1.9	-1.6	-1.5	-0.9	1.6	-0.6	-0.1	0.3
Extinction: sum of active levers before priming	0.4	0.6	1.5	0.1	-0.3	1.0	-0.7	-0.4	-0.8	0.9	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.8	-0.1	0.4	-0.6	0.7	0.4	0.8	-0.9	0.5
Bone: final force	0.1	0.2	0.4	-0.6	0.6	0.3	0.4	-0.4	0.4	-0.2	0.1
Bone: final moment	0.2	0.4	0.8	-0.9	0.9	0.3	0.7	-0.6	0.6	-0.4	0.3
Food consumed during 24 hour testing period	1.1	2.2	5.2	-1.0	0.2	2.3	-0.8	-1.9	-1.2	1.7	-1.7
Glucose	16.3	25.7	55.7	-3.0	-0.2	7.5	-3.3	-5.4	-4.6	6.3	-6.3
Heart weight	1.1	1.8	3.3	0.4	-1.0	1.4	-1.5	-0.7	-1.7	1.8	-1.6
Delay discount hyperbolic model param	1.3	1.6	4.0	2.0	-1.7	-1.4	-1.1	1.6	-0.8	0.1	0.1
Intermittent access intake day 1-15 change	0.2	1.2	2.8	-0.6	0.2	1.7	-0.6	-1.2	-0.9	1.3	-1.3
Intermittent access intake escalation	0.2	1.0	2.3	-0.5	0.1	1.5	-0.6	-1.2	-0.9	1.2	-1.2
Intermittent access intake escalation 2	0.1	0.2	0.5	-0.3	-0.0	0.7	-0.3	-0.6	-0.4	0.6	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	0.6	-0.6	-0.2	-0.6	0.4	-0.5	0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.4	2.2	4.6	-0.8	0.0	2.1	-1.0	-1.7	-1.4	1.9	-1.7
Intermitt. access escalation Index	0.6	1.7	3.1	0.6	-1.0	1.1	-1.6	-0.5	-1.7	1.8	-1.6
Intermittent access day 1 total infusions	0.4	1.1	1.9	-0.9	1.2	-0.4	1.3	0.1	1.4	-1.2	0.9
Intermittent access day 15 total infusions	0.5	1.1	2.6	-1.6	1.4	1.3	0.8	-1.3	0.5	0.0	-0.3
Intermittent access terminal intake (last 3 days)	0.4	0.8	1.8	-1.3	1.3	0.7	0.9	-0.8	0.8	-0.4	-0.1
Intermittent access total infusions	0.8	0.9	2.1	-1.4	1.5	0.5	1.1	-0.7	1.0	-0.6	0.2
Intermittent access day 1 locomotion	0.4	0.8	1.4	-0.3	0.6	-0.9	1.0	0.5	1.1	-1.2	1.0
Intermittent access day 15 total locomotion	0.2	0.6	1.6	-1.3	1.2	0.9	0.6	-0.9	0.4	-0.0	-0.2
Intermittent access total locomotion	0.6	0.7	1.6	-1.3	1.2	0.7	0.8	-0.8	0.7	-0.3	0.0
Intermittent access standard deviation	0.1	0.4	0.9	0.5	-0.1	-1.0	0.3	0.7	0.5	-0.7	0.8
Left kidney weight	0.2	1.7	3.0	-0.9	1.3	-1.0	1.6	0.4	1.7	-1.6	1.3
Right kidney weight	0.7	4.7	8.0	-0.9	1.8	-1.9	2.6	0.8	2.8	-2.8	2.6
Cocaine induced anxiety	0.6	1.5	3.8	-1.7	1.3	1.8	0.4	-2.0	0.0	0.6	-0.5
Post-drug Anxiety	1.3	1.4	3.6	-1.3	0.8	1.9	-0.0	-1.9	-0.5	1.0	-0.8
Baseline Anxiety	0.2	0.4	0.7	0.6	-0.7	0.3	-0.8	0.1	-0.8	0.7	-0.7
Tail length	1.3	7.0	14.2	-3.7	3.8	1.4	3.0	-2.6	2.5	-1.5	1.3
Length with tail	1.5	6.6	13.7	-3.7	3.7	1.6	2.9	-2.6	2.4	-1.3	1.1
Length without tail	0.1	0.4	0.8	-0.9	0.8	0.7	0.6	-0.9	0.4	-0.1	0.1
Times rat made contact with spout	2.6	3.0	5.2	0.6	-1.4	1.6	-2.0	-0.7	-2.2	2.3	-2.1
Lifetime Intake	1.0	1.2	2.6	-1.4	1.6	0.3	1.4	-0.6	1.3	-1.0	0.5
Liver weight, left	0.8	1.4	2.6	0.1	0.6	-1.5	1.2	0.9	1.4	-1.6	1.5
Liver weight, right	0.7	1.3	3.0	0.8	-0.2	-1.7	0.6	1.4	0.9	-1.4	1.2
Locomotor activity	0.4	0.7	1.4	-0.8	0.1	1.2	-0.4	-0.8	-0.6	1.0	-1.1
Locomotor testing distance	0.5	1.3	2.1	-1.2	1.4	-0.4	1.5	-0.3	1.4	-1.2	1.1
Locomotor testing rearing	0.3	1.3	3.1	-1.8	1.4	1.3	0.8	-1.5	0.5	0.1	-0.2
Locomotion in novel chamber	1.4	1.8	4.2	1.5	-0.8	-2.0	0.2	2.0	0.6	-1.3	1.1
Locomotion in novel chamber post-restriction	1.1	3.4	6.3	2.4	-2.5	-0.7	-2.2	1.7	-1.9	1.2	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.5	-0.5	-0.0	-0.5	0.2	-0.5	0.4	-0.4
Change in fecal boli incidents, locomotor task	1.1	1.1	2.1	0.2	-0.7	1.1	-1.2	-0.5	-1.3	1.4	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.1	-0.3	0.2	-0.3	-0.1	-0.4	0.4	-0.3
Bouts of movement, locomotor time 1	0.9	1.2	2.0	-0.2	-0.4	1.4	-1.0	-0.9	-1.2	1.4	-1.4
Total resting periods, locomotor time 1	1.4	1.6	2.8	0.3	-0.9	1.2	-1.4	-0.5	-1.6	1.7	-1.7
Rest time, locomotor task time 1	0.4	0.6	1.2	0.2	-0.6	0.8	-0.9	-0.6	-1.0	1.1	-0.9
Distance moved, locomotor task time 1	0.4	1.0	1.7	-0.9	1.2	-0.5	1.3	-0.0	1.3	-1.1	1.0
Vertical activity count, locomotor time 1	0.1	0.5	0.9	-0.6	0.8	-0.4	0.9	0.2	0.9	-0.9	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.4	0.3	-0.3	-0.2	-0.4	0.6	-0.2	0.1	-0.5
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	0.1	0.0	-0.0	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.1	-0.1	0.3	-0.2	-0.1	-0.3	0.3	-0.4
Rest time, locomotor task time 2	0.2	0.3	0.5	0.5	-0.7	0.3	-0.7	-0.2	-0.7	0.7	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.1	0.0	-0.4	0.1	0.5	0.2	-0.3	0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.2	0.3	-0.4	0.4	0.3	0.5	-0.5	0.3
Light reinforcement 1	0.2	0.9	1.6	-0.8	1.2	-0.4	1.3	-0.2	1.2	-1.1	1.0
Light reinforcement 2	0.6	1.4	2.5	-0.9	1.3	-0.8	1.5	0.3	1.6	-1.5	1.2
Bone: marrow area	0.0	0.0	0.1	-0.2	0.3	-0.0	0.2	0.1	0.3	-0.2	-0.1
Bone: maximum diameter	1.8	3.6	8.5	-2.4	1.5	2.9	0.2	-2.8	-0.4	1.4	-1.3
Bone: maximum force	0.2	0.5	0.9	-0.7	0.9	0.0	0.9	-0.4	0.8	-0.7	0.6
Bone: maximum moment	0.4	0.8	1.5	-1.0	1.2	0.0	1.2	-0.5	1.1	-0.9	0.8
Mean time between licks in bursts	0.3	2.0	3.6	-0.2	-0.7	1.7	-1.4	-1.1	-1.6	1.9	-1.8
Mean num. licks in bursts	1.3	3.5	6.2	2.2	-2.5	0.0	-2.4	1.0	-2.2	1.7	-1.6
Cd content in liver	0.5	0.6	1.4	-0.5	0.0	1.2	-0.4	-0.8	-0.6	0.9	-1.0
Co content in liver	0.4	0.4	0.8	-0.7	0.9	-0.1	0.9	-0.3	0.8	-0.7	0.6
Cu content in liver	0.2	0.2	0.4	-0.2	-0.0	0.7	-0.3	-0.5	-0.5	0.6	-0.5
Fe content in liver	1.6	1.9	4.0	2.0	-2.0	-0.8	-1.5	1.5	-1.2	0.7	-0.6
K content in liver	3.2	3.2	6.2	-1.9	2.5	-0.1	2.3	-0.9	2.1	-1.7	1.5
Mg content in liver	0.5	0.5	1.2	-0.8	1.1	0.1	0.9	-0.5	0.8	-0.6	0.6
Mn content in liver	1.0	1.1	1.9	-0.7	1.4	-0.4	1.3	-0.3	1.3	-1.2	1.2
Na content in liver	1.2	1.3	3.2	-1.4	1.0	1.8	0.1	-1.6	-0.2	0.8	-1.0
Rb content in liver	1.4	1.6	3.4	-1.8	1.8	0.6	1.4	-1.3	1.2	-0.7	0.7
Se content in liver	1.6	1.9	4.0	-1.5	2.0	0.2	1.7	-1.0	1.5	-1.2	1.1
Sr content in liver	1.8	1.6	3.8	-1.6	0.9	1.9	0.1	-1.7	-0.3	1.0	-1.1
Zn content in liver	0.5	0.6	1.2	-0.8	1.1	0.1	1.0	-0.4	0.9	-0.7	0.6
Bone: minimum diameter	0.1	0.2	0.4	-0.1	0.3	-0.4	0.5	0.3	0.5	-0.6	0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.3	-0.1	-0.4	0.0	0.3	0.1	-0.2	0.3
Time in novel zone, hab. session 1	0.4	0.5	0.9	-0.9	0.9	0.1	0.8	-0.5	0.8	-0.5	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.0	-0.2	0.4	-0.3	-0.4	-0.4	0.5	-0.2
Total locomotion distance, hab. session 1	0.2	0.2	0.4	-0.5	0.6	0.1	0.5	-0.6	0.4	-0.2	0.6
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.0	-0.1	0.3	-0.2	-0.3	-0.3	0.3	0.0
Time in familiar zone, hab. session 2	1.0	1.1	2.9	1.5	-1.3	-1.3	-0.7	1.7	-0.4	-0.2	-0.0
Time in novel zone, hab. session 2	1.5	1.6	4.1	-1.8	1.5	1.5	0.9	-2.0	0.5	0.1	0.1
Total zone transitions, hab. session 2	0.3	0.4	1.2	-0.8	0.6	0.9	0.2	-1.1	-0.1	0.4	-0.1
Total locomotion distance, hab. session 2	0.5	0.7	1.8	-0.7	0.4	1.3	-0.2	-1.4	-0.5	0.9	-0.4
Locomotion velocity, hab. session 2	0.5	0.7	1.9	-0.9	0.6	1.2	0.0	-1.4	-0.3	0.7	-0.3
Novel to familiar place preference ratio	0.7	1.0	2.2	-0.6	0.0	1.5	-0.6	-1.0	-0.8	1.1	-1.4
Novelty place preference	0.8	1.0	2.4	-0.7	0.0	1.6	-0.6	-1.1	-0.8	1.2	-1.4
Time in novel zone, NPP test	0.8	1.0	2.4	-0.7	0.1	1.6	-0.6	-1.1	-0.8	1.2	-1.3
Total zone transitions, NPP test	0.4	0.5	1.3	0.5	0.0	-1.1	0.4	0.6	0.6	-0.8	1.1
Total locomotion distance, NPP test	0.1	0.1	0.5	0.2	0.0	-0.4	0.2	0.1	0.2	-0.3	0.7
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.0	0.2	-0.3	0.3	-0.1	0.3	-0.3	0.6
Intraocular pressure	0.6	1.0	1.8	-0.1	-0.5	1.1	-1.0	-0.6	-1.2	1.3	-1.3
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.8	-0.7	-0.8	-0.3	0.9	-0.1	-0.2	0.2
Delta ambulatory time before/after self-admin	0.2	0.4	0.9	0.9	-0.8	-0.7	-0.4	0.8	-0.2	-0.1	0.2
Parametrial fat weight	3.4	8.0	15.4	-0.9	-0.8	3.7	-2.4	-2.3	-3.0	3.7	-3.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.5	0.2	0.5	-0.1	-0.3	-0.2	0.4	-0.5
Pavlov. Cond. magazine entry latency	0.9	1.2	3.3	1.8	-1.4	-1.2	-0.8	1.4	-0.5	-0.1	0.2
Pavlov. Cond. change in total contacts	0.6	0.6	1.8	-0.8	0.6	1.3	0.1	-1.3	-0.2	0.5	-0.6
Pavlov. Cond. index score	0.7	0.9	2.6	1.6	-1.1	-1.3	-0.4	1.2	-0.2	-0.4	0.6
Pavlov. Cond. latency score	0.6	0.8	1.9	1.4	-0.9	-1.2	-0.3	1.1	-0.0	-0.5	0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.9	-0.5	-0.9	0.0	0.6	0.1	-0.5	0.7
Pavlov. Cond. magazine entry number	1.0	1.3	3.9	-2.0	1.6	1.0	1.0	-1.2	0.8	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.4	-1.2	1.5	-0.3	1.5	-0.1	1.5	-1.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.9	1.7	-1.1	-1.4	-0.4	1.3	-0.1	-0.6	0.7
Pavlov. Cond. response bias	0.3	0.4	1.3	1.1	-0.6	-0.8	-0.2	0.6	-0.0	-0.4	0.6
Pavlov. Cond. lever latency	3.1	4.3	8.3	-2.8	2.9	0.7	2.6	-1.7	2.3	-1.5	1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	-0.2	0.2	-0.2	-0.1	-0.3	0.2	-0.1
Pavlov. Cond. change in total contacts	0.2	0.5	0.8	0.7	-0.8	0.1	-0.9	0.4	-0.8	0.7	-0.6
Pavlov. Cond. index score	0.8	1.2	2.3	1.5	-1.5	-0.3	-1.4	0.8	-1.2	0.8	-0.7
Pavlov. Cond. latency score	0.7	1.1	2.6	1.6	-1.5	-0.5	-1.2	1.0	-1.0	0.6	-0.5
Pavlov. Cond. lever contacts	2.7	4.0	7.8	2.8	-2.8	-0.9	-2.4	1.8	-2.0	1.3	-1.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.5	0.6	-0.5	0.8	0.1	0.8	-0.8	0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.0	-0.2	0.0	-0.1	-0.1	-0.1	0.1	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	2.4	1.5	-1.4	-0.5	-1.2	0.9	-1.1	0.6	-0.5
Pavlov. Cond. response bias	1.7	2.4	4.3	2.0	-2.1	-0.4	-1.9	1.1	-1.7	1.2	-1.0
Time in closed arm before self-admin	0.6	1.0	1.6	-0.9	1.1	-0.4	1.3	-0.3	1.3	-1.1	1.2
Time in closed arm after self-admin	1.4	1.6	4.2	1.4	-1.0	-2.0	0.1	1.7	0.4	-1.0	1.3
Time in open arm before self-admin	0.2	0.3	0.8	0.9	-0.7	-0.5	-0.4	0.7	-0.3	-0.0	-0.1
Time in open arm after self-admin	0.9	1.0	2.7	-0.5	0.1	1.5	-0.7	-0.8	-0.8	1.1	-1.6
Bone: periosteal estimation	0.4	0.9	2.0	-1.4	1.4	0.6	1.0	-0.9	0.9	-0.5	0.2
Bone: periosteal perimeter	0.5	1.0	2.8	-1.7	1.3	1.0	0.9	-1.3	0.6	-0.1	-0.1
Bone: post-yield work	0.0	0.1	0.3	-0.3	0.2	0.4	0.1	-0.5	0.0	0.1	0.0
Progressive ratio test 1 active lever presses	0.3	0.5	1.2	-1.0	1.1	0.3	0.8	-0.5	0.8	-0.5	0.2
Progressive ratio test 1 breakpoint	0.2	0.4	1.0	-1.0	1.0	0.4	0.7	-0.5	0.6	-0.4	0.1
Progressive ratio test 1 inactive lever presses	0.9	2.4	5.4	-2.3	1.9	2.0	0.9	-2.2	0.5	0.4	-0.5
Progressive ratio test 2 active lever presses	0.4	0.5	1.2	-1.1	1.1	0.7	0.6	-0.8	0.5	-0.1	-0.2
Progressive ratio test 2 breakpoint	0.3	0.4	0.8	-0.9	0.9	0.8	0.4	-0.7	0.3	0.0	-0.3
Progressive ratio test 2 inactive lever presses	0.3	0.8	2.0	-1.1	0.8	1.4	-0.1	-1.1	-0.3	0.7	-1.1
Incentive Sensitization - Responses	0.1	0.2	0.5	-0.4	0.3	0.7	-0.2	-0.5	-0.3	0.5	-0.6
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.3	0.2	0.6	-0.2	-0.4	-0.3	0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	-0.5	0.3	0.4	0.3	-0.7	0.2	-0.0	0.1
Progressive ratio	0.1	0.4	0.9	0.1	0.1	-0.9	0.6	0.8	0.8	-0.9	0.6
Food seeking constrained by brief footshock	3.2	4.0	7.2	-2.5	2.7	0.4	2.5	-1.4	2.3	-1.6	1.5
Seeking ratio, punishment vs. effort	0.3	0.7	1.6	-1.2	1.2	0.7	0.8	-1.3	0.5	-0.1	0.5
Retroperitoneal fat weight	0.8	3.5	6.6	-0.4	-0.7	2.4	-1.7	-1.4	-2.0	2.5	-2.6
Reaction time number correct	0.1	0.5	0.8	0.2	-0.5	0.8	-0.7	-0.5	-0.8	0.9	-0.8
Reaction time mean minus median	0.4	2.4	4.4	1.8	-2.1	-0.2	-2.0	0.9	-1.9	1.4	-1.1
Reaction time mean minus median AUC	0.1	0.9	1.9	1.4	-1.4	-0.5	-1.1	0.8	-1.0	0.6	-0.2
Reaction time num false alarms	0.5	0.9	1.4	-0.7	1.1	-0.1	1.2	-0.6	1.1	-1.0	1.1
Reaction time num false alarms AUC	0.7	1.5	2.6	-0.7	1.3	-0.6	1.6	-0.4	1.5	-1.5	1.6
Reaction time trials correct on left	0.1	0.5	0.8	0.2	-0.5	0.8	-0.7	-0.5	-0.8	0.9	-0.8
Reaction time trials on left	0.1	0.5	0.8	0.2	-0.5	0.7	-0.7	-0.4	-0.8	0.9	-0.8
Reaction time mean	0.4	0.8	1.8	1.2	-1.3	-0.6	-1.0	1.0	-0.9	0.5	-0.3
Reaction time mean AUC	0.4	0.9	1.8	1.3	-1.3	-0.9	-0.9	1.2	-0.7	0.3	-0.0
Median of all reaction times	0.3	0.4	0.8	0.8	-0.9	-0.7	-0.6	0.9	-0.4	0.2	-0.0
Reaction time omissions	0.6	1.0	2.3	1.5	-1.3	-1.1	-0.7	1.4	-0.4	-0.1	0.2
Reaction time false alarm rate	1.5	2.1	3.6	-0.8	1.5	-0.8	1.8	-0.2	1.8	-1.8	1.9
Reaction time premature initiation rate	1.2	1.8	4.4	1.5	-0.8	-2.1	0.2	1.7	0.6	-1.2	1.6
Reaction time premature initiations	0.2	0.7	1.6	1.3	-0.8	-1.2	-0.2	1.0	0.0	-0.5	0.9
Std. dev. reaction times	0.6	2.1	4.0	1.8	-2.0	-0.4	-1.8	1.1	-1.6	1.2	-0.9
Reaction time trials completed	0.1	0.5	0.8	0.2	-0.5	0.7	-0.7	-0.4	-0.8	0.9	-0.8
Reaction time trials AUC	0.1	0.4	0.6	0.0	-0.3	0.8	-0.6	-0.6	-0.7	0.8	-0.7
Run reversals in cocaine runway, females	0.6	0.6	1.5	1.1	-1.2	-0.5	-0.9	0.7	-0.8	0.4	-0.0
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.8	0.9	0.4	0.7	-0.6	0.5	-0.3	0.3
Latency to leave start box in cocaine runway	0.5	0.6	1.1	-0.5	0.8	-0.6	1.0	0.3	1.0	-1.0	0.9
Latency to leave start box in cocaine runway, F	1.3	1.6	2.7	-1.4	1.7	-0.2	1.6	-0.5	1.5	-1.2	1.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	0.8	-0.8	-0.7	-0.4	1.0	-0.2	-0.1	-0.1
Std. dev. time between licks in bursts	0.1	0.3	0.4	0.3	-0.5	0.4	-0.6	-0.2	-0.7	0.6	-0.5
Total sessions with >9 infusions	1.3	1.6	3.0	0.1	0.5	-1.5	1.2	1.0	1.5	-1.7	1.5
Short access day 1 total inactive lever presses	1.5	3.0	6.6	-2.6	2.4	1.1	1.9	-1.7	1.6	-0.8	0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.3	0.2	0.1	0.2	-0.3	0.1	-0.0	0.3
Short access day 1 total infusions	0.7	1.4	2.8	0.0	0.6	-1.3	1.2	0.9	1.5	-1.7	1.5
Short access day 10 total infusions	0.6	1.1	2.1	-0.2	0.7	-1.1	1.1	0.8	1.3	-1.5	1.0
Short access total infusions	1.2	1.8	3.2	-0.9	1.4	-0.8	1.7	0.3	1.8	-1.7	1.2
Short access day 1 locomotion	1.5	2.5	4.7	0.1	0.7	-1.7	1.7	1.0	1.9	-2.2	2.1
Short access day 10 total locomotion	0.5	1.8	3.3	0.3	0.4	-1.7	1.2	1.2	1.5	-1.8	1.8
Short access total locomotion	1.5	2.2	4.1	0.3	0.4	-1.9	1.3	1.3	1.7	-2.0	1.9
One hour access (0.3 mA shock)	0.7	0.9	2.2	-1.4	1.5	0.8	0.9	-0.9	0.7	-0.3	-0.2
Compulsive drug intake	0.7	1.0	2.6	1.3	-0.9	-1.4	-0.4	1.6	-0.0	-0.5	0.4
One hour access (shock baseline)	0.4	0.9	2.1	-1.5	1.4	1.1	0.7	-1.1	0.5	-0.1	-0.5
Social response proportion	1.6	2.0	3.5	-0.5	-0.3	1.9	-1.2	-1.3	-1.5	1.9	-1.9
Social responses	1.8	2.3	4.9	-0.8	0.0	2.2	-1.1	-1.6	-1.4	2.0	-1.9
Social time	0.6	0.9	1.7	0.3	-0.8	0.9	-1.1	-0.4	-1.2	1.3	-1.2
Soleus weight	1.2	3.5	6.4	-2.1	2.5	-0.2	2.4	-0.6	2.3	-1.9	1.2
Bone: stiffness	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.1	0.2	-0.1	-0.0	0.1
Tibialis anterior weight	0.5	1.8	4.1	-2.0	1.5	1.7	0.9	-1.9	0.5	0.2	-0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.2	0.2	-0.2	0.4	-0.1	0.4	-0.3	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	0.5	-0.5	-0.7	-0.2	0.4	-0.1	-0.1	0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.8	-0.2	0.6	-0.6	0.8	0.4	0.9	-0.9	0.7
Time to tail flick, test, after self-admin	1.7	1.8	3.9	-2.0	1.8	0.8	1.4	-1.6	1.1	-0.5	0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.5	-0.5	-0.5	-0.4	0.6	-0.3	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.6	0.7	1.6	-0.7	0.2	1.3	-0.3	-1.3	-0.6	1.0	-0.7
Tibia length	1.1	3.1	5.7	-0.3	1.2	-2.0	1.9	1.1	2.2	-2.4	2.0
Ambulatory time before self-admin	0.8	2.4	4.2	-1.6	1.9	-0.1	2.0	-0.6	2.0	-1.6	1.4
Ambulatory time after self-admin	0.9	1.4	2.5	-0.7	1.1	-0.7	1.5	0.1	1.6	-1.5	1.4
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.1	0.1	-0.1	0.2	-0.4
Total heroin consumption	0.0	0.0	0.1	0.1	0.0	-0.3	0.1	0.0	0.1	-0.2	0.3
Bone: trabecular number	0.3	0.5	0.9	-0.2	0.6	-0.5	0.9	0.1	0.9	-1.0	0.9
Bone: trabecular spacing	0.4	0.6	1.3	-1.0	0.6	1.2	0.0	-1.1	-0.2	0.6	-0.6
Bone: trabecular thickness	0.7	1.0	2.5	0.9	-0.3	-1.6	0.4	1.2	0.7	-1.1	1.1
Bone: trabecular tissue density	0.9	1.6	2.7	1.1	-1.6	0.3	-1.6	0.3	-1.6	1.4	-1.2
Water consumed over 24 hours	1.0	1.9	4.5	-0.7	0.0	2.1	-0.8	-1.6	-1.2	1.7	-1.5
Number of responses in last shaping day	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.1	0.5	-0.1	-0.1	-0.1