Hub : Genes

Gapdhs

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS XM_006228791.5 0.03 0.02 2.7e-03 0.01 0.02 0.02 0.01 6.5e-02 4.1e-03 8.6e-03 2.1e-02
2 Brain alternative TSS XM_063273145.1 0.03 0.03 1.1e-03 0.01 0.03 0.02 0.02 1.5e-02 9.7e-04 3.4e-03 3.9e-03
3 PL alternative TSS XM_006228791.5 0.03 0.02 1.7e-03 0 0.02 0.01 0.01 1.1e-01 5.2e-03 5.0e-02 2.5e-02
4 NAcc alternative TSS XM_006228791.5 0.03 0.03 1.7e-03 0.02 0.01 0.01 0.02 2.8e-04 1.8e-03 1.6e-02 4.3e-04
5 Brain isoform ratio XM_006228791.5 0.06 0.04 9.2e-05 0.06 0.05 0.05 0.05 1.2e-06 2.1e-05 2.5e-05 8.2e-06
6 NAcc alternative TSS XM_006228791.5 0.05 0.03 1.6e-07 0.05 0.05 0.04 0.04 1.2e-07 4.6e-08 4.2e-06 2.1e-07
7 OFC alternative TSS XM_006228790.5 0.14 0.09 7.0e-03 0.1 0.07 0 0.1 1.9e-03 8.0e-03 2.3e-01 2.9e-03
8 NAcc mRNA stability Gapdhs 0.03 0.02 9.2e-04 0.02 0.02 0.02 0.02 1.3e-03 4.6e-04 2.5e-04 1.4e-03
9 LHb mRNA stability Gapdhs 0.16 0.1 2.6e-03 0.13 0.1 0.11 0.1 6.0e-04 2.0e-03 1.8e-03 2.6e-03
10 Brain mRNA stability Gapdhs 0.11 0.06 1.4e-11 0.12 0.12 0.1 0.11 5.3e-11 5.8e-11 5.9e-10 2.0e-10
11 NAcc alternative TSS XM_039090188.2 0.04 0.03 2.8e-06 0.03 0.04 0.04 0.04 1.1e-05 3.9e-07 3.4e-06 2.2e-06
12 Brain gene expression Gapdhs 0.05 0.04 8.8e-05 0.05 0.05 0.03 0.05 2.3e-05 2.0e-05 5.8e-04 3.5e-05
13 Adipose gene expression Gapdhs 0.08 0.05 4.5e-08 0.05 0.05 0.05 0.05 3.9e-06 2.5e-06 4.4e-06 6.0e-06
14 BLA alternative TSS XM_006228791.5 0.14 0.11 9.6e-03 -0 0.02 -0 0.01 5.2e-01 2.1e-02 3.5e-01 5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.01.82.4-1.51.51.41.5-1.41.21.1-1.5-1.5-1.5-1.11.31.20.7
Area under the delay curve0.30.41.2-0.0-0.1-0.1-0.20.8-0.4-0.60.00.80.80.7-0.8-0.9-1.1
BMI with tail0.20.61.40.5-0.7-0.7-0.20.4-0.6-0.80.81.11.00.7-0.7-0.9-1.2
BMI without tail0.10.20.9-0.50.40.30.3-0.1-0.1-0.1-0.10.40.30.4-0.3-0.5-0.9
Body weight1.87.716.2-4.03.83.63.1-2.82.42.8-2.8-2.6-2.5-1.82.31.90.3
Weight adjusted by age0.10.10.3-0.50.50.3-0.0-0.20.10.6-0.3-0.4-0.4-0.00.10.2-0.0
Bone surface0.40.72.4-1.61.51.20.5-0.80.30.7-0.9-0.9-1.0-0.10.40.3-0.3
Bone volume0.71.33.4-1.91.81.50.9-1.10.71.0-1.2-1.3-1.3-0.40.80.7-0.0
Breakpoint value in progressive ratio session0.10.20.6-0.70.50.50.3-0.10.1-0.0-0.30.30.30.2-0.2-0.3-0.8
Number of licking bursts2.94.76.72.2-2.3-2.3-2.12.4-2.2-2.32.62.22.21.9-1.9-1.9-1.5
Context. condit. distance diff. score0.70.91.60.3-0.5-0.7-1.00.7-1.1-1.11.00.90.91.2-1.0-1.1-1.3
Locomotion velocity, session 10.10.10.30.00.1-0.10.3-0.00.30.5-0.1-0.6-0.5-0.40.50.50.3
Locomotion distance, session 10.40.51.9-0.70.6-0.0-0.60.5-0.9-0.30.30.00.01.1-0.7-0.7-1.4
Locomotion velocity, session 20.40.51.41.0-0.8-0.9-0.91.2-0.7-0.50.60.40.40.5-0.7-0.5-0.0
Locomotion distance, session 22.94.05.51.5-1.5-2.1-2.02.1-2.4-1.52.01.81.82.3-2.2-2.2-2.3
Locomotion velocity, session 30.40.51.30.5-0.4-0.8-1.10.9-1.0-0.30.60.40.30.9-0.8-0.6-0.5
Locomotion distance, session 31.21.34.1-0.80.60.1-1.11.1-1.4-0.60.60.70.61.7-1.5-1.4-2.0
Stereotopy head waving bouts, day 31.21.43.70.2-0.00.41.2-1.11.51.0-1.2-0.9-0.9-1.71.41.41.9
Stereotopy head waving duration, day 30.91.13.30.6-0.4-0.01.0-1.11.30.7-1.0-0.6-0.6-1.61.21.31.8
Locomotion velocity, session 70.40.41.8-0.40.3-0.1-0.40.6-0.7-0.20.40.50.40.9-0.8-0.9-1.3
Locomotion distance, session 70.10.10.4-0.60.70.2-0.1-0.0-0.30.50.1-0.3-0.40.4-0.1-0.1-0.5
Stereotopy head waving bouts, day 72.22.53.71.8-1.9-1.7-1.71.9-1.6-1.61.51.61.71.4-1.4-1.3-0.8
Stereotopy head waving duration, day 71.21.43.11.7-1.8-1.5-1.11.3-0.9-1.31.11.31.30.7-0.8-0.8-0.3
Locomotion velocity, session 84.25.06.52.3-2.3-2.6-2.42.3-2.3-2.22.42.22.22.1-2.2-2.1-1.7
Locomotion distance, session 83.65.37.81.4-1.5-2.1-2.62.3-2.8-2.02.42.12.02.8-2.5-2.5-2.6
Degree of sensitization distance0.90.92.0-0.10.20.41.0-1.01.00.9-0.6-0.9-0.9-1.31.21.21.4
Degree of sensitization stereotypy3.23.55.11.8-1.9-1.8-2.12.3-2.0-2.01.81.91.91.9-1.8-1.7-1.3
Conditioned locomotion0.60.71.51.1-1.2-0.9-0.40.6-0.6-1.10.81.11.10.6-0.7-0.8-0.5
Cocaine response after cond. corrected1.11.32.6-0.30.40.71.3-1.01.50.7-0.7-1.1-1.1-1.61.41.41.6
Cocaine response after cond. not corrected1.92.35.2-0.50.71.01.4-1.31.71.2-1.1-1.6-1.6-1.91.71.92.3
Cocaine response before conditioning0.50.61.4-1.01.20.9-0.2-0.50.11.0-0.9-1.1-1.1-0.20.40.70.7
Saline control response0.10.10.30.10.00.00.2-0.20.40.5-0.0-0.4-0.4-0.50.40.50.5
Bone: connectivity density0.10.20.4-0.60.60.50.3-0.40.20.1-0.6-0.5-0.5-0.10.20.20.1
Bone: cortical apparent density0.60.81.51.0-1.0-1.2-0.70.9-0.8-0.91.20.80.80.8-0.7-0.8-0.9
Bone: cortical area1.32.03.4-1.81.91.61.2-1.51.21.7-1.3-1.5-1.5-1.01.21.20.7
Bone: cortical porosity4.34.68.72.0-2.0-2.0-2.52.9-2.2-2.21.82.22.22.1-2.3-2.0-1.4
Bone: cortical porosity5.45.810.32.2-2.2-2.3-2.63.2-2.5-2.52.22.52.42.3-2.5-2.3-1.6
Bone: cortical thickness1.01.62.0-1.41.41.31.1-1.41.21.4-1.3-1.4-1.3-1.11.21.20.9
Bone: cortical thickness0.00.00.10.3-0.3-0.40.1-0.20.10.20.10.00.0-0.20.20.10.1
Bone: cortical tissue density0.91.22.01.1-1.2-1.4-0.91.1-1.0-1.11.41.01.00.9-0.9-1.0-1.1
Condit. Reinf. active minus inactive responses0.10.10.30.5-0.4-0.5-0.30.2-0.3-0.40.40.40.40.3-0.4-0.4-0.3
Condit. Reinf. active-inactive response ratio0.50.51.20.10.00.30.8-1.01.10.6-0.7-0.5-0.6-1.10.80.81.0
Condit. Reinf. active responses1.82.33.21.7-1.7-1.8-1.01.4-1.3-1.71.81.61.61.2-1.4-1.5-1.3
Condit. Reinf. inactive responses4.35.37.61.9-2.1-2.3-1.72.6-2.3-2.62.82.32.42.3-2.2-2.4-2.4
Incentive salience index mean0.40.50.60.6-0.6-0.7-0.50.5-0.6-0.80.80.70.70.6-0.8-0.8-0.7
Condit. Reinf. lever presses0.50.71.00.6-0.6-0.6-0.50.9-0.7-1.01.00.90.90.8-1.0-1.0-1.0
Condit. Reinf. active minus inactive responses0.30.31.0-0.81.00.80.2-0.20.30.6-0.6-0.7-0.7-0.20.10.30.2
Condit. Reinf. active-inactive response ratio0.00.00.10.1-0.1-0.2-0.20.2-0.0-0.10.3-0.1-0.1-0.0-0.00.00.1
Condit. Reinf. active responses0.50.72.5-1.51.61.30.3-0.30.30.9-1.0-1.0-1.0-0.10.10.30.0
Condit. Reinf. inactive responses0.30.41.3-1.21.11.0-0.20.2-0.30.3-0.7-0.3-0.30.6-0.5-0.3-0.5
Condit. Reinf. lever presses2.53.58.0-2.72.82.51.2-1.61.32.0-2.3-2.1-2.1-1.01.11.20.6
Condit. Reinf. lever reinforcers received0.40.62.4-1.51.61.20.0-0.1-0.00.7-0.8-0.8-0.80.3-0.10.1-0.3
Conditioned reinforcement - actives0.10.20.90.8-0.6-0.6-0.41.0-0.3-0.20.50.10.10.1-0.1-0.00.4
Conditioned reinforcement - inactives2.33.45.20.9-1.0-1.3-1.72.1-2.0-1.91.42.02.02.2-2.3-2.2-2.3
Conditioned locomotion1.31.73.11.8-1.7-1.6-0.91.5-1.0-1.31.51.41.40.8-1.0-0.9-0.4
Patch foraging indifference point 0 sec0.00.10.20.3-0.2-0.1-0.50.5-0.2-0.40.20.10.10.2-0.4-0.20.3
Patch foraging indifference point AUC0.20.30.80.9-0.8-0.7-0.10.9-0.2-0.60.50.60.60.1-0.3-0.3-0.1
Delay disc. indifference point, 0s delay1.71.96.8-0.0-0.3-0.6-0.41.2-1.2-1.71.51.51.51.6-1.2-1.7-2.6
Delay disc. indifference point, 16s delay0.50.51.20.1-0.2-0.0-0.10.9-0.4-0.80.11.01.00.7-0.9-1.0-1.1
Delay disc. indifference point, 2s delay0.30.42.3-0.80.60.30.30.3-0.4-0.00.30.40.40.7-0.5-0.8-1.5
Delay disc. indifference point, 24s delay0.20.20.8-0.90.80.80.50.10.2-0.2-0.40.10.10.2-0.2-0.3-0.8
Delay disc. indifference point, 4s delay1.01.12.10.7-0.7-0.8-1.01.5-1.1-0.90.51.11.11.1-1.3-1.2-1.0
Delay disc. indifference point, 8s delay0.00.00.2-0.10.00.1-0.20.4-0.1-0.1-0.40.10.10.2-0.2-0.1-0.0
Indifference point function ln k0.10.20.5-0.60.70.3-0.3-0.7-0.10.7-0.4-0.5-0.50.2-0.00.1-0.2
Indifference point function log k0.10.20.5-0.60.70.3-0.3-0.7-0.10.7-0.4-0.5-0.50.2-0.00.1-0.2
Patch foraging total patch changes 0 sec0.00.10.30.2-0.00.0-0.40.5-0.2-0.30.10.10.10.2-0.4-0.10.2
Patch foraging total patch changes 12 sec0.10.10.60.4-0.2-0.00.00.50.30.0-0.3-0.1-0.1-0.40.10.30.8
Patch foraging total patch changes 18 sec0.30.51.40.6-0.7-0.5-0.71.2-0.7-1.00.60.70.70.6-0.7-0.6-0.2
Patch foraging total patch changes 24 sec0.10.10.3-0.50.30.4-0.00.5-0.3-0.40.30.10.10.4-0.2-0.3-0.5
Patch foraging total patch changes 6 sec0.00.10.40.3-0.10.10.00.30.2-0.1-0.1-0.1-0.1-0.3-0.00.20.6
Patch foraging time to switch 0 sec0.20.41.30.8-0.8-0.10.7-0.10.8-0.10.00.00.0-0.90.60.61.2
Patch foraging water rate 0 sec0.51.11.61.0-0.8-1.3-1.21.0-1.2-0.81.11.01.01.1-1.3-1.1-1.0
Patch foraging water rate 12 sec0.20.51.8-0.40.50.0-1.30.5-1.2-0.2-0.1-0.0-0.01.1-0.8-0.6-0.6
Patch foraging water rate 18 sec0.10.10.40.4-0.3-0.5-0.70.2-0.5-0.20.10.10.10.4-0.5-0.3-0.1
Patch foraging water rate 24 sec3.14.37.70.8-0.9-1.6-2.61.9-2.7-1.61.71.91.92.8-2.5-2.4-2.6
Patch foraging water rate 6 sec0.60.92.6-0.50.5-0.1-1.20.7-1.3-0.60.30.50.51.5-1.3-1.2-1.6
Seeking ratio, delayed vs. immediate footshock0.60.72.8-0.70.40.2-0.40.4-0.9-0.80.50.80.81.2-0.9-1.1-1.7
Distance traveled before self-admin0.00.00.2-0.0-0.0-0.00.00.4-0.2-0.10.30.10.10.2-0.1-0.2-0.2
Distance traveled after self-admin0.81.01.9-1.41.41.40.5-0.50.71.2-1.3-1.1-1.1-0.60.80.90.7
Extensor digitorum longus weight0.52.15.5-0.80.70.82.3-2.42.01.2-1.0-0.9-0.9-1.81.81.30.7
Bone: elastic displacement0.40.51.2-0.20.30.60.6-0.30.80.7-0.7-0.7-0.7-0.90.80.91.1
Bone: elastic work1.41.82.7-1.61.61.61.4-1.11.31.4-1.5-1.3-1.3-1.11.21.10.7
Bone: endosteal estimation0.61.32.8-1.61.71.40.6-1.10.61.5-1.1-1.3-1.3-0.50.70.80.5
Bone: endosteal perimeter0.20.41.5-1.21.21.00.2-0.70.10.8-0.4-0.7-0.70.00.20.3-0.1
Epididymis fat weight0.10.20.6-0.60.60.20.5-0.80.10.4-0.6-0.2-0.2-0.00.20.0-0.6
Delta time in closed arm before/after self-admin0.60.61.3-1.11.11.00.8-0.90.60.9-0.7-0.7-0.7-0.50.60.50.0
Delta time in open arm before/after self-admin0.20.20.50.7-0.5-0.5-0.60.2-0.3-0.40.2-0.1-0.10.1-0.30.00.5
Diff in mean of infusions in LGA sessions0.91.12.21.2-1.3-1.1-0.60.4-0.7-1.11.01.51.50.7-0.9-1.0-0.9
Delay discount exponential model param0.20.20.70.1-0.0-0.10.1-0.60.30.30.2-0.6-0.6-0.50.60.70.8
Extinction: sum of active levers before priming5.25.77.7-2.62.52.62.8-2.42.42.6-2.6-2.2-2.2-2.22.42.21.4
Active lever presses in extinction session 66.46.48.3-1.92.12.42.6-2.02.82.5-2.3-2.6-2.6-2.92.82.82.6
Bone: final force0.91.43.1-1.81.71.51.0-1.21.01.2-1.4-1.1-1.0-0.70.90.80.1
Bone: final moment1.32.04.4-2.12.11.81.2-1.51.21.5-1.6-1.4-1.3-0.91.11.00.2
Food consumed during 24 hour testing period0.50.71.5-0.10.0-0.2-1.11.1-1.1-0.20.40.60.61.2-1.1-1.0-1.1
Glucose0.40.61.7-0.00.20.20.2-0.20.60.8-0.7-1.0-1.0-0.90.91.11.3
Heart weight0.40.61.20.3-0.1-0.6-1.00.8-1.0-0.60.10.60.61.0-1.1-0.9-1.0
Delay discount hyperbolic model param0.20.30.90.10.10.00.2-0.60.30.30.1-0.7-0.7-0.60.70.70.9
Intermittent access intake day 1-15 change0.91.83.9-2.01.81.81.5-1.71.31.4-0.9-1.1-1.1-1.01.31.00.2
Intermittent access intake escalation1.02.13.8-2.01.81.81.5-1.81.41.6-0.9-1.3-1.3-1.11.51.20.4
Intermittent access intake escalation 21.61.82.4-1.41.41.51.2-1.41.41.5-1.2-1.4-1.4-1.31.31.31.1
Intermitt. access day 1 inactive lever presses0.10.51.4-1.21.01.00.30.20.0-0.1-0.80.30.30.4-0.5-0.6-1.1
Intermitt. access day 15 inactive lever presses0.61.33.30.0-0.2-0.3-0.60.9-1.0-1.30.61.31.31.4-1.5-1.6-1.8
Intermitt. access escalation Index1.11.52.90.8-0.8-1.1-1.70.9-1.6-1.31.31.01.01.6-1.3-1.2-1.1
Intermittent access day 1 total infusions4.36.99.72.3-2.4-2.6-3.03.1-3.0-2.42.82.62.62.8-2.6-2.4-2.0
Intermittent access day 15 total infusions0.81.22.20.3-0.5-0.7-1.21.2-1.3-0.91.51.11.11.4-1.0-1.1-1.3
Intermittent access terminal intake (last 3 days)2.23.04.21.1-1.3-1.4-2.01.8-2.0-1.51.91.81.82.0-1.8-1.7-1.6
Intermittent access total infusions2.93.44.91.3-1.4-1.6-2.22.1-2.2-1.62.11.91.92.1-1.8-1.8-1.6
Intermittent access day 1 locomotion6.27.910.12.1-2.3-2.5-2.93.2-3.2-2.72.83.03.03.1-3.0-2.9-2.6
Intermittent access day 15 total locomotion1.22.23.40.7-0.9-1.1-1.61.6-1.8-1.21.71.51.51.9-1.6-1.6-1.6
Intermittent access total locomotion3.34.05.61.7-1.8-1.9-1.82.4-2.1-1.82.22.12.12.0-2.0-2.0-1.7
Intermittent access standard deviation0.20.52.4-1.61.31.30.4-0.30.20.4-0.6-0.4-0.40.10.20.1-0.5
Left kidney weight1.88.615.0-3.93.73.63.3-2.62.73.0-2.8-2.9-2.9-2.22.72.30.9
Right kidney weight2.712.519.0-4.44.34.13.9-3.43.33.9-3.5-3.6-3.6-2.83.32.91.5
Cocaine induced anxiety0.20.31.5-0.30.30.41.2-0.50.80.2-0.4-0.2-0.2-0.70.60.30.1
Post-drug Anxiety0.20.20.60.3-0.5-0.10.80.10.3-0.8-0.00.50.5-0.1-0.1-0.4-0.5
Baseline Anxiety0.91.11.70.7-0.8-0.7-1.11.3-1.0-1.30.61.11.11.1-1.2-1.2-0.9
Tail length2.49.219.8-4.44.44.02.7-2.62.33.4-3.3-3.1-3.1-1.82.32.20.7
Length with tail3.314.529.7-5.55.45.03.4-3.43.04.0-4.3-3.9-3.9-2.32.92.81.1
Length without tail1.96.212.6-3.53.53.12.3-2.42.02.6-2.6-2.6-2.6-1.61.91.80.5
Times rat made contact with spout0.40.50.9-0.20.30.20.4-0.80.60.8-0.2-0.9-0.9-0.80.90.90.8
Lifetime Intake2.12.54.71.2-1.3-1.5-2.21.9-2.0-1.21.81.51.51.8-1.5-1.4-1.1
Liver weight, left0.10.20.50.7-0.6-0.7-0.60.3-0.3-0.40.40.10.10.2-0.2-0.10.2
Liver weight, right0.00.10.10.4-0.1-0.30.3-0.10.20.3-0.3-0.3-0.3-0.30.10.10.2
Locomotor activity0.71.13.40.30.10.10.5-0.71.01.0-1.1-1.2-1.2-1.31.01.31.8
Locomotor testing distance0.20.41.70.5-0.2-0.3-0.2-0.20.30.6-0.5-0.7-0.7-0.60.50.81.3
Locomotor testing rearing0.30.61.61.2-1.0-1.3-1.20.8-0.9-0.30.90.30.30.5-0.4-0.30.2
Locomotion in novel chamber0.10.20.70.5-0.4-0.2-0.2-0.40.40.2-0.3-0.1-0.1-0.50.20.40.8
Locomotion in novel chamber post-restriction0.00.00.20.4-0.4-0.2-0.00.00.1-0.3-0.10.20.2-0.2-0.0-0.00.2
Fecal boli incidents, locomotor time 10.71.03.51.9-1.8-1.4-0.31.3-0.2-0.80.91.11.1-0.1-0.4-0.40.4
Change in fecal boli incidents, locomotor task1.91.93.0-0.60.81.01.6-1.61.71.2-1.4-1.3-1.3-1.71.51.51.6
Time >=10cm from walls, locomotor time 10.00.00.20.1-0.1-0.0-0.1-0.10.1-0.4-0.40.10.1-0.1-0.00.00.2
Bouts of movement, locomotor time 11.11.23.2-0.1-0.1-0.4-0.81.2-1.3-1.10.90.90.91.5-1.3-1.4-1.8
Total resting periods, locomotor time 10.70.82.1-0.0-0.1-0.4-0.61.0-1.1-0.90.70.90.91.2-1.1-1.2-1.5
Rest time, locomotor task time 10.70.82.21.5-1.5-1.20.11.0-0.1-1.10.51.21.20.1-0.5-0.6-0.3
Distance moved, locomotor task time 10.10.10.4-0.30.3-0.0-0.6-0.4-0.50.40.4-0.0-0.00.5-0.2-0.1-0.3
Vertical activity count, locomotor time 10.20.41.3-1.11.10.9-0.2-0.6-0.20.6-0.3-0.7-0.70.3-0.00.0-0.2
Time >=10cm from walls, locomotor time 20.91.42.51.6-1.5-1.5-1.21.3-1.0-1.11.01.31.30.8-1.1-1.0-0.5
Bouts of movement, locomotor time 20.10.20.60.2-0.1-0.3-0.80.5-0.7-0.30.10.00.00.6-0.4-0.3-0.2
Total resting periods, locomotor time 20.10.20.80.4-0.3-0.5-0.90.5-0.7-0.30.10.10.10.5-0.5-0.20.0
Rest time, locomotor task time 20.20.20.80.9-0.8-0.6-0.00.5-0.0-0.60.10.50.5-0.1-0.2-0.10.3
Distance moved, locomotor task time 20.40.41.00.1-0.2-0.5-1.00.4-1.0-0.10.80.50.51.0-0.7-0.7-1.0
Vertical activity count, locomotor time 20.10.20.7-0.70.60.3-0.30.0-0.40.20.1-0.1-0.10.6-0.4-0.4-0.8
Light reinforcement 10.30.81.70.7-0.6-0.8-1.31.1-1.1-0.70.60.80.81.0-1.0-0.9-0.7
Light reinforcement 20.81.32.71.6-1.5-1.6-1.00.7-0.8-1.11.11.11.10.8-1.0-1.0-0.8
Bone: marrow area0.71.53.0-1.71.71.50.7-1.20.81.5-1.2-1.4-1.4-0.70.81.00.6
Bone: maximum diameter0.71.32.6-1.61.61.51.1-1.31.01.3-1.0-1.0-1.1-0.80.90.90.4
Bone: maximum force1.22.15.2-2.32.21.91.2-1.41.11.5-1.6-1.4-1.4-0.71.00.90.0
Bone: maximum moment1.52.76.4-2.52.52.11.4-1.61.21.7-1.7-1.6-1.6-0.91.21.10.1
Mean time between licks in bursts0.30.81.60.4-0.4-0.7-1.10.4-1.1-0.70.60.90.91.2-1.3-1.1-1.1
Mean num. licks in bursts3.04.76.3-2.12.22.12.0-2.52.22.5-2.3-2.3-2.3-2.02.22.11.6
Cd content in liver0.00.00.10.1-0.20.00.1-0.20.30.1-0.00.10.1-0.30.30.20.3
Co content in liver0.10.20.50.4-0.3-0.10.5-0.30.60.2-0.1-0.0-0.0-0.70.40.40.6
Cu content in liver0.60.71.7-1.31.31.11.0-0.80.71.0-0.7-0.7-0.7-0.50.60.4-0.3
Fe content in liver0.10.10.50.7-0.5-0.6-0.30.3-0.20.00.20.30.30.1-0.3-0.20.0
K content in liver0.00.00.10.2-0.00.1-0.00.10.10.1-0.20.00.0-0.1-0.10.00.3
Mg content in liver0.20.20.90.5-0.2-0.10.4-0.20.70.4-0.4-0.3-0.3-0.80.30.50.9
Mn content in liver0.70.73.20.5-0.30.10.4-0.51.00.7-0.6-0.6-0.6-1.30.91.11.8
Na content in liver0.10.10.4-0.60.60.60.0-0.20.10.3-0.3-0.4-0.4-0.10.20.30.3
Rb content in liver0.30.41.00.4-0.6-0.40.10.3-0.1-0.70.61.01.00.3-0.5-0.7-0.9
Se content in liver0.60.73.51.9-1.6-1.40.10.40.2-0.20.70.40.4-0.5-0.10.00.7
Sr content in liver0.20.21.10.5-0.3-0.2-0.20.20.20.3-0.2-0.3-0.3-0.50.30.51.1
Zn content in liver0.20.31.11.1-0.9-0.70.4-0.10.5-0.10.10.40.4-0.60.10.00.3
Bone: minimum diameter0.40.72.8-1.71.61.30.3-0.30.00.8-0.6-0.6-0.60.3-0.00.0-0.5
Time in familiar zone, hab. session 13.23.15.0-1.71.81.62.2-2.21.91.9-1.4-1.8-1.7-1.81.91.60.9
Time in novel zone, hab. session 14.44.47.22.2-2.2-2.1-2.72.3-2.2-1.81.52.22.22.0-2.3-1.9-1.1
Total zone transitions, hab. session 10.70.91.80.3-0.3-0.8-1.21.1-1.3-0.71.00.60.61.3-1.1-1.1-1.3
Total locomotion distance, hab. session 10.20.31.3-0.20.30.1-1.10.7-0.8-0.0-0.3-0.3-0.30.7-0.6-0.20.1
Locomotion velocity, hab. session 10.10.20.6-0.20.40.2-0.80.5-0.40.1-0.4-0.6-0.60.2-0.20.20.5
Time in familiar zone, hab. session 22.62.83.9-1.21.41.71.7-1.92.01.6-1.7-1.4-1.4-1.91.61.71.8
Time in novel zone, hab. session 21.01.01.60.9-0.9-1.2-1.21.3-1.2-0.81.00.80.81.1-0.9-1.0-0.9
Total zone transitions, hab. session 23.54.46.62.3-2.1-2.5-2.62.2-2.3-1.92.21.81.82.1-2.1-1.9-1.4
Total locomotion distance, hab. session 21.72.25.11.3-1.2-1.5-2.31.6-1.9-1.41.01.21.21.7-1.7-1.4-0.9
Locomotion velocity, hab. session 21.31.74.11.3-1.2-1.4-2.01.4-1.7-1.20.91.01.01.5-1.5-1.2-0.7
Novel to familiar place preference ratio0.00.00.1-0.10.10.1-0.10.0-0.2-0.30.00.00.00.3-0.3-0.3-0.3
Novelty place preference0.10.10.20.0-0.1-0.1-0.40.2-0.4-0.30.20.20.20.4-0.4-0.4-0.3
Time in novel zone, NPP test0.20.20.40.2-0.2-0.3-0.60.4-0.6-0.50.40.30.30.6-0.6-0.5-0.5
Total zone transitions, NPP test0.10.20.50.00.0-0.5-0.70.5-0.7-0.10.4-0.1-0.10.7-0.4-0.4-0.7
Total locomotion distance, NPP test0.91.22.6-1.51.61.20.0-0.80.31.2-1.4-1.6-1.6-0.30.60.90.7
Locomotion velocity, NPP test1.01.42.7-1.51.61.40.2-0.90.51.4-1.7-1.6-1.6-0.50.71.00.9
Intraocular pressure0.20.30.60.5-0.7-0.5-0.80.2-0.6-0.70.60.60.60.6-0.5-0.5-0.3
Delta distance traveled before/after self-admin1.11.22.3-1.51.51.40.5-0.90.81.2-1.4-1.2-1.2-0.60.80.90.7
Delta ambulatory time before/after self-admin0.70.92.1-1.51.41.30.3-0.70.51.0-1.2-1.0-1.0-0.30.60.70.4
Parametrial fat weight2.04.88.3-0.81.01.42.6-2.42.81.9-2.0-2.1-2.0-2.92.52.42.6
Pavlov. Cond. lever latency0.81.02.4-0.90.81.01.6-1.21.31.1-0.8-0.6-0.6-1.11.20.90.4
Pavlov. Cond. magazine entry latency1.11.45.71.4-1.0-1.5-2.41.3-1.7-0.60.50.30.41.2-1.2-0.60.3
Pavlov. Cond. change in total contacts3.33.56.91.5-1.4-1.8-2.62.1-2.4-1.71.61.51.52.2-2.2-1.8-1.2
Pavlov. Cond. index score1.21.55.11.4-1.1-1.4-2.21.3-1.7-0.90.80.60.61.3-1.4-0.8-0.0
Pavlov. Cond. latency score1.21.64.61.2-1.0-1.3-2.11.4-1.7-1.00.90.70.71.4-1.5-1.0-0.3
Pavlov. Cond. lever contacts0.60.72.30.7-0.5-0.7-1.51.0-1.2-0.90.70.40.41.0-1.1-0.7-0.1
Pavlov. Cond. magazine entry number1.31.65.9-1.41.01.52.4-1.31.90.9-0.7-0.6-0.6-1.51.40.90.1
Pavlov. Cond. intertrial magazine entries0.20.20.70.5-0.5-0.50.50.10.0-0.60.80.40.40.0-0.1-0.4-0.6
Pavlov. Cond. lever-magazine prob. diff.1.62.06.31.6-1.3-1.7-2.51.5-1.9-1.10.90.70.71.5-1.6-1.0-0.1
Pavlov. Cond. response bias0.50.63.11.0-0.6-0.9-1.80.6-1.1-0.20.1-0.1-0.10.7-0.7-0.10.7
Pavlov. Cond. lever latency1.01.44.52.1-2.1-1.8-0.80.8-0.5-1.01.51.21.20.2-0.3-0.40.3
Pavlov. Cond. magazine entry latency0.70.82.2-1.41.51.30.6-0.60.50.8-1.3-0.9-0.9-0.30.30.40.2
Pavlov. Cond. change in total contacts1.32.17.3-2.72.62.30.9-1.10.71.2-1.5-1.3-1.3-0.20.60.5-0.3
Pavlov. Cond. index score1.41.85.3-2.32.31.90.9-1.00.71.3-1.7-1.4-1.4-0.40.50.6-0.0
Pavlov. Cond. latency score1.01.34.0-2.02.01.70.7-0.80.51.0-1.5-1.2-1.2-0.20.30.4-0.1
Pavlov. Cond. lever contacts1.11.65.1-2.32.21.80.8-0.90.61.1-1.5-1.2-1.2-0.20.40.4-0.4
Pavlov. Cond. magazine entry number1.41.84.72.1-2.2-1.8-1.01.1-0.7-1.31.61.51.50.5-0.7-0.7-0.0
Pavlov. Cond. intertrial magazine entries0.20.41.20.9-1.1-0.7-0.00.5-0.1-0.60.90.70.70.0-0.1-0.3-0.0
Pavlov. Cond. lever-magazine prob. diff.1.51.95.2-2.22.32.00.9-1.10.81.3-1.8-1.5-1.5-0.50.60.70.1
Pavlov. Cond. response bias1.31.86.1-2.52.41.90.8-1.00.51.1-1.5-1.3-1.3-0.00.40.3-0.6
Time in closed arm before self-admin2.12.64.41.6-1.7-1.7-1.41.9-1.6-2.11.71.61.61.5-1.5-1.5-1.3
Time in closed arm after self-admin0.90.92.20.3-0.6-0.6-0.50.8-0.8-1.20.71.11.11.0-1.0-1.2-1.5
Time in open arm before self-admin4.34.77.0-2.32.42.41.8-2.12.02.6-2.6-2.2-2.2-1.91.92.01.8
Time in open arm after self-admin1.71.92.9-1.11.41.40.8-1.11.21.6-1.4-1.7-1.7-1.31.21.51.7
Bone: periosteal estimation1.22.65.2-2.22.31.91.1-1.71.12.0-1.6-1.8-1.8-1.01.21.30.7
Bone: periosteal perimeter0.81.32.1-1.41.51.30.7-1.20.91.5-1.0-1.3-1.3-0.80.91.10.9
Bone: post-yield work0.30.41.3-1.11.00.6-0.30.2-0.50.1-0.00.0-0.00.8-0.6-0.6-1.1
Progressive ratio test 1 active lever presses1.21.53.20.5-0.6-0.8-1.31.8-1.5-1.01.31.21.21.5-1.2-1.2-1.2
Progressive ratio test 1 breakpoint1.31.63.30.5-0.6-0.8-1.41.8-1.6-1.11.31.21.21.6-1.3-1.3-1.3
Progressive ratio test 1 inactive lever presses4.15.98.61.0-1.2-1.6-2.62.9-2.7-2.42.12.42.42.9-2.8-2.8-2.9
Progressive ratio test 2 active lever presses0.40.41.20.3-0.4-0.6-0.61.0-0.8-0.41.10.60.60.7-0.4-0.5-0.6
Progressive ratio test 2 breakpoint0.50.61.50.5-0.5-0.7-0.81.1-0.9-0.51.20.70.70.8-0.5-0.6-0.7
Progressive ratio test 2 inactive lever presses1.93.07.10.4-0.7-1.0-1.21.6-1.7-1.81.62.12.12.0-1.9-2.2-2.7
Incentive Sensitization - Responses0.30.41.10.4-0.5-0.7-0.50.6-0.6-0.41.10.60.60.6-0.3-0.5-0.7
Incentive Sensitization - Breakpoint0.30.41.10.4-0.5-0.7-0.50.5-0.6-0.41.10.60.60.6-0.4-0.5-0.8
Sum of active levers in priming session hrs 5-60.00.00.2-0.0-0.00.00.4-0.20.30.20.20.10.1-0.30.30.20.0
Progressive ratio0.30.51.10.8-0.6-0.7-1.11.0-0.8-0.90.20.50.50.7-0.8-0.6-0.1
Food seeking constrained by brief footshock0.50.61.5-1.11.21.10.4-0.20.40.7-1.2-0.9-0.9-0.40.30.50.5
Seeking ratio, punishment vs. effort0.10.10.5-0.70.60.50.4-0.00.10.3-0.2-0.2-0.20.10.0-0.1-0.5
Retroperitoneal fat weight1.46.112.6-0.30.81.12.5-2.32.82.3-2.2-2.6-2.6-3.32.83.03.5
Reaction time number correct0.00.10.2-0.30.40.20.4-0.40.20.3-0.3-0.4-0.4-0.20.30.2-0.1
Reaction time mean minus median0.20.61.0-0.80.81.01.0-0.70.80.9-0.6-0.7-0.7-0.70.80.70.6
Reaction time mean minus median AUC0.61.62.4-1.41.31.51.5-1.21.31.3-1.1-1.2-1.2-1.21.31.20.9
Reaction time num false alarms0.40.51.21.0-1.1-0.8-0.50.7-0.4-0.91.00.90.90.3-0.4-0.5-0.1
Reaction time num false alarms AUC0.40.71.61.2-1.3-0.9-0.70.8-0.5-1.01.00.90.90.3-0.5-0.50.0
Reaction time trials correct on left0.00.10.2-0.30.40.20.4-0.40.20.3-0.3-0.4-0.4-0.20.30.2-0.1
Reaction time trials on left0.10.10.2-0.40.40.20.5-0.50.30.4-0.4-0.4-0.4-0.30.30.2-0.0
Reaction time mean0.10.10.3-0.60.50.4-0.1-0.4-0.10.5-0.2-0.3-0.30.10.20.20.1
Reaction time mean AUC0.10.10.2-0.40.40.4-0.1-0.40.00.5-0.3-0.4-0.4-0.10.20.30.3
Median of all reaction times0.00.10.4-0.10.0-0.1-0.60.0-0.50.00.10.00.00.5-0.2-0.1-0.1
Reaction time omissions0.30.51.2-0.30.50.40.2-0.80.60.9-0.6-0.8-0.8-0.70.70.91.1
Reaction time false alarm rate0.50.71.51.1-1.2-0.9-0.80.9-0.6-1.01.01.01.00.4-0.6-0.5-0.0
Reaction time premature initiation rate0.81.12.20.8-0.9-0.8-1.11.5-1.2-0.90.81.11.11.1-1.3-1.1-0.7
Reaction time premature initiations0.40.81.50.7-0.7-0.7-0.81.2-1.0-0.70.60.90.91.0-1.1-1.0-0.8
Std. dev. reaction times0.20.31.0-1.00.90.90.5-0.60.30.8-0.3-0.5-0.5-0.20.50.40.1
Reaction time trials completed0.10.10.2-0.40.40.20.5-0.50.30.4-0.4-0.4-0.4-0.30.30.2-0.0
Reaction time trials AUC0.20.30.5-0.40.50.30.7-0.70.50.6-0.5-0.6-0.6-0.50.60.50.3
Run reversals in cocaine runway, females0.20.20.8-0.90.70.60.1-0.40.00.2-0.0-0.1-0.10.20.0-0.2-0.8
Run reversals in cocaine runway, males3.53.57.3-0.61.01.21.6-1.32.11.9-2.0-2.0-2.0-2.42.02.32.7
Latency to leave start box in cocaine runway0.30.31.6-0.50.20.20.40.3-0.3-0.50.60.50.50.6-0.3-0.6-1.3
Latency to leave start box in cocaine runway, F0.70.82.9-0.0-0.2-0.4-0.40.8-0.8-0.80.80.90.91.1-0.9-1.2-1.7
Latency to leave start box in cocaine runway, M0.00.00.2-0.2-0.00.20.20.2-0.1-0.20.50.10.10.10.20.1-0.1
Std. dev. time between licks in bursts2.12.84.81.2-1.2-1.2-2.21.9-2.0-1.71.01.71.72.0-2.2-1.8-1.2
Total sessions with >9 infusions0.40.51.60.9-0.7-1.0-1.30.8-0.9-0.20.70.30.30.5-0.4-0.20.2
Short access day 1 total inactive lever presses3.54.611.30.3-0.6-1.1-1.62.2-2.3-2.22.02.22.22.6-2.4-2.7-3.4
Short access day 10 total inactive lever presses0.51.36.5-0.80.50.2-0.10.5-0.8-1.20.70.90.91.4-1.3-1.6-2.6
Short access day 1 total infusions0.50.71.80.4-0.3-0.7-1.30.9-1.1-0.50.80.60.61.0-0.9-0.8-0.7
Short access day 10 total infusions0.50.61.80.7-0.7-0.8-1.40.9-1.0-0.50.90.50.50.7-0.5-0.40.0
Short access total infusions0.60.82.40.9-0.8-1.1-1.61.1-1.1-0.41.00.60.60.8-0.7-0.4-0.0
Short access day 1 locomotion0.50.71.00.9-0.9-1.0-0.80.9-0.8-0.70.81.01.00.7-0.7-0.6-0.4
Short access day 10 total locomotion0.81.53.00.7-0.7-0.8-1.61.7-1.6-1.00.81.11.11.6-1.6-1.3-0.9
Short access total locomotion1.92.33.71.7-1.6-1.7-1.81.9-1.7-1.31.31.41.41.4-1.5-1.2-0.6
One hour access (0.3 mA shock)1.61.93.70.2-0.3-0.7-1.91.6-1.9-0.91.21.21.21.9-1.6-1.5-1.6
Compulsive drug intake1.31.62.60.7-0.6-1.0-1.51.4-1.5-1.31.11.01.01.5-1.6-1.5-1.4
One hour access (shock baseline)0.40.61.40.3-0.4-0.6-1.20.7-1.1-0.30.80.80.81.1-0.8-0.7-0.7
Social response proportion0.50.61.2-1.11.01.01.0-0.90.80.9-0.6-0.3-0.3-0.50.40.3-0.2
Social responses0.10.10.3-0.30.40.40.6-0.40.50.6-0.10.00.0-0.3-0.0-0.0-0.1
Social time0.40.52.0-1.41.40.90.1-0.9-0.10.3-0.2-0.2-0.20.4-0.2-0.3-1.0
Soleus weight0.10.20.4-0.10.20.20.7-0.60.60.4-0.3-0.3-0.3-0.60.50.40.3
Bone: stiffness0.50.92.5-1.61.51.20.9-1.20.60.8-1.0-0.8-0.8-0.30.50.3-0.5
Tibialis anterior weight0.93.05.6-1.11.11.22.2-2.42.21.7-1.2-1.5-1.4-2.12.21.91.4
Time to tail flick, vehicle, before self-admin0.50.50.90.6-0.5-0.7-1.00.5-0.9-0.90.80.50.50.8-0.8-0.7-0.6
Time to tail flick, vehicle, after self-admin0.10.10.50.2-0.10.1-0.50.50.0-0.1-0.3-0.1-0.1-0.1-0.00.30.7
Time to tail flick, test, before self-admin1.91.95.00.2-0.5-0.9-1.11.2-1.7-1.51.41.31.31.8-1.4-1.7-2.2
Time to tail flick, test, after self-admin0.10.10.20.4-0.4-0.4-0.50.2-0.3-0.40.00.30.30.3-0.3-0.3-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.30.30.60.00.30.30.4-0.7-0.4-0.4-0.30.30.50.7
Delta time to tail flick, test, before/after SA1.01.14.00.4-0.10.20.6-0.61.21.0-1.0-0.9-0.9-1.51.01.32.0
Tibia length1.23.38.4-2.92.82.31.5-1.81.12.1-2.0-1.9-1.9-0.71.21.0-0.2
Ambulatory time before self-admin0.00.10.20.1-0.20.00.10.4-0.1-0.20.20.30.30.2-0.2-0.3-0.3
Ambulatory time after self-admin1.01.23.1-1.81.71.70.8-0.60.71.2-1.5-1.0-1.0-0.40.70.70.2
Bone: tissue strength0.40.41.4-1.21.00.80.10.2-0.1-0.1-0.30.10.10.5-0.3-0.4-1.0
Total heroin consumption0.30.41.3-0.20.0-0.1-0.30.6-0.6-0.60.30.80.80.8-0.6-0.8-1.1
Bone: trabecular number0.61.02.4-1.61.51.31.0-1.10.70.6-1.2-1.0-1.0-0.50.70.5-0.1
Bone: trabecular spacing0.50.72.6-0.30.40.70.2-0.30.80.8-0.9-0.9-0.9-0.90.71.11.6
Bone: trabecular thickness0.10.10.6-0.40.30.10.6-0.30.1-0.10.1-0.0-0.00.10.2-0.2-0.8
Bone: trabecular tissue density1.01.53.90.3-0.00.11.0-0.91.31.2-0.6-1.2-1.2-1.71.61.62.0
Water consumed over 24 hours0.50.61.2-1.01.10.80.6-0.80.61.1-0.8-1.0-1.0-0.50.60.60.2
Number of responses in last shaping day0.40.41.4-0.00.1-0.4-1.20.8-1.1-0.20.50.10.10.9-0.7-0.4-0.4