Hub : Genes

Gadd45gip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Gadd45gip1 0.07 0.04 1.8e-07 0.02 0.03 0.04 0.04 2.6e-04 5.6e-06 1.8e-07 1.6e-06
2 Brain mRNA stability Gadd45gip1 0.19 0.08 2.1e-12 0.15 0.11 0.13 0.13 8.1e-14 2.0e-10 4.9e-12 2.5e-12
3 IL mRNA stability Gadd45gip1 0.23 0.12 3.6e-03 0.04 0.02 0.03 0 3.1e-02 1.1e-01 7.8e-02 2.8e-01
4 IC mRNA stability Gadd45gip1 0.18 0.1 6.5e-04 0.02 0.06 0.05 0.04 6.3e-02 2.2e-03 2.6e-03 1.2e-02
5 Liver mRNA stability Gadd45gip1 0.12 0.06 6.2e-10 0.09 0.08 0.08 0.09 1.8e-10 7.5e-09 2.1e-09 4.5e-10
6 Adipose mRNA stability Gadd45gip1 0.34 0.11 0.0e+00 0.25 0.23 0.24 0.15 1.3e-27 1.1e-25 6.7e-27 1.8e-16
7 PL mRNA stability Gadd45gip1 0.14 0.07 1.5e-09 0.06 0.09 0.09 0.09 3.2e-07 8.1e-10 6.5e-10 1.6e-09
8 pVTA mRNA stability Gadd45gip1 0.12 0.06 2.1e-05 0.04 0.05 0.04 0.04 6.7e-04 3.9e-05 1.6e-04 7.9e-04
9 Brain gene expression Gadd45gip1 0.08 0.04 1.4e-05 0.05 0.05 0.05 0.05 1.4e-05 1.9e-05 1.5e-05 2.4e-05
10 Liver gene expression Gadd45gip1 0.57 0.11 0.0e+00 0.42 0.41 0.42 0.42 5.1e-51 2.8e-48 9.2e-50 3.1e-51
11 RMTg gene expression Gadd45gip1 0.7 0.12 5.0e-16 0.4 0.23 0.45 0.28 1.1e-11 6.6e-07 2.1e-13 3.7e-08
12 Adipose gene expression Gadd45gip1 0.3 0.1 0.0e+00 0.21 0.2 0.21 0.21 8.4e-23 7.3e-22 2.2e-23 4.3e-23
13 IC gene expression Gadd45gip1 0.17 0.09 3.5e-05 0.09 0.11 0.08 0.07 1.4e-04 2.9e-05 2.9e-04 4.9e-04
14 BLA mRNA stability Gadd45gip1 0.13 0.07 4.9e-05 0.02 0.04 0.06 0.04 3.6e-02 5.4e-03 2.6e-04 5.8e-03
15 RMTg mRNA stability Gadd45gip1 0.27 0.13 1.1e-03 0.1 0.07 0.09 0.1 1.3e-03 5.7e-03 2.9e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density3.15.89.52.92.72.7-1.82.72.71.9-1.43.1-2.62.32.8-2.41.12.0
Area under the delay curve0.10.20.40.1-0.3-0.30.7-0.2-0.2-0.60.70.50.30.20.3-0.2-0.20.6
BMI with tail1.76.010.4-2.5-2.8-2.82.2-2.6-2.6-2.41.5-2.63.2-2.8-2.82.4-0.1-1.4
BMI without tail0.00.20.6-0.1-0.6-0.60.8-0.2-0.2-0.80.60.10.7-0.2-0.2-0.10.30.7
Body weight0.10.31.1-0.5-0.4-0.4-0.6-0.4-0.40.1-0.7-1.00.5-0.5-1.10.30.3-0.2
Weight adjusted by age0.20.50.7-0.8-0.7-0.70.8-0.8-0.8-0.80.8-0.70.7-0.6-0.40.6-0.6-0.5
Bone surface2.85.69.72.52.52.5-1.52.52.51.7-0.72.9-2.92.83.1-2.8-0.32.1
Bone volume3.05.99.92.62.72.7-1.82.52.51.9-1.02.9-3.12.83.1-2.8-0.22.0
Breakpoint value in progressive ratio session0.61.24.70.20.10.1-1.30.10.11.3-1.8-0.80.2-1.1-1.11.02.2-1.3
Number of licking bursts0.10.41.80.90.40.4-0.60.40.40.4-0.90.60.20.3-0.1-0.41.31.0
Context. condit. distance diff. score1.51.93.1-1.4-1.6-1.61.0-1.7-1.7-1.20.6-1.61.7-1.3-1.81.2-0.2-0.4
Locomotion velocity, session 11.41.62.21.41.41.4-1.31.11.11.3-1.01.3-1.51.31.3-1.30.51.2
Locomotion distance, session 10.40.51.90.70.60.6-1.20.30.30.8-1.40.3-0.10.3-0.2-0.31.30.6
Locomotion velocity, session 20.80.91.51.21.21.2-0.71.01.00.7-0.81.1-0.60.70.7-0.81.11.2
Locomotion distance, session 20.30.51.80.0-0.1-0.1-0.9-0.4-0.40.4-1.3-0.60.7-0.5-1.10.41.30.0
Locomotion velocity, session 30.10.10.5-0.2-0.2-0.20.5-0.2-0.2-0.40.60.10.00.20.2-0.2-0.70.3
Locomotion distance, session 31.01.15.21.00.40.40.30.60.6-0.40.61.5-0.51.51.3-1.7-0.62.3
Stereotopy head waving bouts, day 31.01.24.1-1.0-1.0-1.01.7-0.7-0.7-1.52.0-0.30.3-0.00.3-0.0-2.0-0.0
Stereotopy head waving duration, day 30.50.61.7-0.8-0.9-0.91.3-0.6-0.6-1.21.3-0.40.6-0.5-0.20.4-0.9-0.3
Locomotion velocity, session 70.20.20.5-0.2-0.5-0.50.5-0.3-0.3-0.60.4-0.20.7-0.1-0.4-0.00.10.7
Locomotion distance, session 70.30.41.50.70.50.5-0.90.50.50.8-1.00.4-0.10.3-0.0-0.31.20.7
Stereotopy head waving bouts, day 70.60.61.90.3-0.1-0.10.90.10.1-0.91.20.8-0.20.81.0-1.1-1.11.4
Stereotopy head waving duration, day 70.70.82.10.90.60.60.40.70.7-0.30.71.3-0.71.11.4-1.4-0.71.5
Locomotion velocity, session 80.20.21.00.10.10.1-1.0-0.3-0.30.7-1.0-0.3-0.10.1-0.60.00.6-0.1
Locomotion distance, session 80.50.82.6-0.4-0.8-0.8-0.3-1.0-1.0-0.2-0.8-1.01.3-0.8-1.60.71.20.1
Degree of sensitization distance0.70.81.8-0.30.10.1-1.00.00.01.0-1.3-1.00.2-0.9-1.11.11.3-1.3
Degree of sensitization stereotypy0.30.41.40.30.00.00.70.10.1-0.70.80.6-0.00.50.7-0.8-0.71.2
Conditioned locomotion0.10.10.40.20.30.3-0.60.20.20.5-0.50.1-0.40.40.1-0.30.00.1
Cocaine response after cond. corrected0.50.71.8-0.5-0.6-0.6-0.4-0.4-0.40.3-0.7-1.10.7-0.9-1.31.11.1-1.1
Cocaine response after cond. not corrected0.50.71.8-0.4-0.5-0.5-0.5-0.4-0.40.4-1.0-1.00.7-0.9-1.31.11.4-1.1
Cocaine response before conditioning0.30.41.00.70.70.7-0.30.50.50.2-0.20.9-0.50.70.7-0.70.11.0
Saline control response2.53.48.42.11.71.7-2.61.81.82.4-2.91.2-0.90.80.3-0.82.91.2
Bone: connectivity density5.79.115.73.63.33.3-1.73.53.52.1-1.24.0-3.03.13.6-3.21.12.9
Bone: cortical apparent density0.40.62.30.0-0.6-0.61.50.00.0-1.21.30.31.0-0.50.00.10.30.9
Bone: cortical area0.10.21.10.40.00.0-1.1-0.1-0.10.7-1.0-0.1-0.30.4-0.3-0.40.40.4
Bone: cortical porosity1.01.12.1-1.4-1.0-1.00.1-1.3-1.3-0.50.1-1.40.8-0.8-1.41.1-0.7-1.3
Bone: cortical porosity0.60.71.4-1.2-0.9-0.90.0-1.1-1.1-0.50.1-1.20.5-0.4-1.00.6-1.0-0.9
Bone: cortical thickness1.01.73.3-1.2-1.6-1.60.5-1.6-1.6-0.90.1-1.71.6-1.3-1.81.10.3-0.6
Bone: cortical thickness1.62.012.30.2-0.4-0.4-0.5-0.5-0.50.3-1.6-0.91.8-1.8-1.91.63.5-0.6
Bone: cortical tissue density0.30.62.20.1-0.5-0.51.50.10.1-1.21.30.40.9-0.40.1-0.10.21.0
Condit. Reinf. active minus inactive responses1.92.15.1-1.0-1.7-1.71.5-1.8-1.8-2.31.6-0.71.5-0.1-0.8-0.4-1.71.6
Condit. Reinf. active-inactive response ratio1.41.53.0-1.1-1.6-1.60.9-1.6-1.6-1.50.7-1.21.7-0.9-1.50.5-0.40.5
Condit. Reinf. active responses0.91.13.2-0.4-0.9-0.91.1-1.1-1.1-1.71.30.10.70.50.0-0.8-1.61.8
Condit. Reinf. inactive responses2.02.64.81.61.71.7-0.91.51.51.0-0.42.0-1.82.22.1-1.9-0.51.8
Incentive salience index mean1.01.35.00.0-0.5-0.50.8-0.8-0.8-1.41.20.60.11.20.7-1.5-1.92.2
Condit. Reinf. lever presses1.21.94.90.80.60.60.00.30.3-0.30.71.6-1.32.21.9-2.1-1.92.2
Condit. Reinf. active minus inactive responses0.10.20.80.20.30.3-0.40.30.30.3-0.10.3-0.60.90.4-0.7-0.60.5
Condit. Reinf. active-inactive response ratio0.10.20.5-0.6-0.3-0.3-0.0-0.4-0.4-0.10.1-0.60.1-0.2-0.40.3-0.5-0.7
Condit. Reinf. active responses0.10.20.50.40.50.5-0.70.40.40.6-0.60.2-0.40.60.1-0.40.10.3
Condit. Reinf. inactive responses0.10.20.80.10.20.2-0.50.10.10.6-0.8-0.20.1-0.3-0.50.50.9-0.2
Condit. Reinf. lever presses0.00.00.3-0.2-0.1-0.10.3-0.0-0.0-0.30.30.00.20.0-0.00.2-0.50.0
Condit. Reinf. lever reinforcers received0.10.10.20.20.40.4-0.40.30.30.4-0.40.2-0.40.40.2-0.2-0.10.2
Conditioned reinforcement - actives0.00.00.2-0.1-0.1-0.1-0.2-0.2-0.2-0.0-0.2-0.2-0.10.0-0.10.0-0.4-0.1
Conditioned reinforcement - inactives0.00.10.4-0.3-0.2-0.20.3-0.2-0.2-0.20.4-0.20.1-0.2-0.10.2-0.6-0.2
Conditioned locomotion0.00.10.3-0.1-0.1-0.10.4-0.1-0.1-0.30.50.10.10.10.2-0.1-0.60.2
Patch foraging indifference point 0 sec0.10.31.3-0.3-0.4-0.40.0-0.6-0.6-0.30.4-0.2-0.20.70.0-0.7-1.10.7
Patch foraging indifference point AUC1.02.54.01.72.02.0-1.72.02.01.9-1.61.4-1.51.11.2-0.91.30.4
Delay disc. indifference point, 0s delay1.21.32.61.41.21.2-0.71.21.20.8-0.31.6-1.41.21.6-1.3-0.00.8
Delay disc. indifference point, 16s delay0.60.92.1-0.7-1.0-1.00.7-0.9-0.9-0.50.2-0.91.2-1.4-1.11.30.6-1.1
Delay disc. indifference point, 2s delay0.80.91.9-0.8-1.0-1.01.3-1.1-1.1-1.41.3-0.30.9-0.4-0.20.4-1.0-0.2
Delay disc. indifference point, 24s delay0.20.30.6-0.7-0.8-0.80.5-0.5-0.5-0.60.5-0.70.6-0.2-0.60.3-0.60.1
Delay disc. indifference point, 4s delay0.90.92.91.10.50.50.40.50.5-0.30.71.7-0.61.21.5-1.2-0.51.5
Delay disc. indifference point, 8s delay0.10.20.80.1-0.2-0.20.7-0.2-0.2-0.70.70.50.40.40.3-0.3-0.10.9
Indifference point function ln k0.92.85.4-1.7-2.0-2.02.1-1.9-1.9-2.32.3-1.11.4-0.7-0.80.4-2.10.2
Indifference point function log k0.92.85.4-1.7-2.0-2.02.1-1.9-1.9-2.32.3-1.11.4-0.7-0.80.4-2.10.2
Patch foraging total patch changes 0 sec0.10.41.4-0.7-0.8-0.80.3-1.0-1.0-0.60.6-0.60.20.3-0.4-0.2-1.20.3
Patch foraging total patch changes 12 sec1.21.52.81.41.21.2-1.60.90.91.1-1.51.1-1.01.60.7-1.50.71.7
Patch foraging total patch changes 18 sec1.74.05.42.32.32.3-2.31.91.92.2-2.11.9-2.02.11.5-1.91.31.7
Patch foraging total patch changes 24 sec0.72.43.31.71.51.5-1.41.71.71.4-1.01.5-1.71.71.6-1.80.31.7
Patch foraging total patch changes 6 sec0.40.71.01.01.01.0-1.00.90.90.9-0.90.9-0.71.00.6-0.70.50.6
Patch foraging time to switch 0 sec0.00.10.40.30.00.0-0.5-0.1-0.10.3-0.70.00.00.0-0.2-0.10.50.1
Patch foraging water rate 0 sec0.00.10.4-0.30.20.2-0.20.10.10.2-0.1-0.4-0.1-0.2-0.20.3-0.2-0.6
Patch foraging water rate 12 sec0.20.62.8-0.3-0.5-0.51.6-0.4-0.4-1.31.70.30.60.00.4-0.1-0.80.5
Patch foraging water rate 18 sec0.61.43.20.50.20.21.20.50.5-0.91.81.4-0.61.21.7-1.4-1.71.7
Patch foraging water rate 24 sec0.50.72.7-0.2-0.4-0.41.4-0.1-0.1-1.21.70.50.10.40.6-0.6-1.41.1
Patch foraging water rate 6 sec3.04.56.22.52.42.4-2.12.52.52.1-1.82.3-2.11.91.9-1.81.51.5
Seeking ratio, delayed vs. immediate footshock1.11.62.8-1.1-1.5-1.51.7-1.4-1.4-1.71.2-0.81.6-1.2-1.01.0-0.3-0.3
Distance traveled before self-admin0.61.42.0-1.4-1.4-1.41.3-1.3-1.3-1.21.3-1.21.0-1.0-0.81.0-1.1-0.9
Distance traveled after self-admin0.71.32.0-1.4-1.1-1.11.3-1.2-1.2-1.31.2-1.21.1-1.1-0.91.1-0.8-0.9
Extensor digitorum longus weight0.31.12.7-1.0-0.9-0.9-0.5-0.9-0.90.3-0.9-1.60.9-1.0-1.61.20.6-1.3
Bone: elastic displacement0.50.71.5-0.9-0.9-0.90.9-1.0-1.0-1.11.1-0.60.6-0.2-0.40.1-1.20.0
Bone: elastic work1.82.43.9-1.8-1.9-1.91.1-2.0-2.0-1.40.9-1.81.5-1.4-1.71.2-0.9-1.1
Bone: endosteal estimation0.30.93.30.80.80.8-1.70.50.51.3-1.80.3-0.70.4-0.1-0.41.20.0
Bone: endosteal perimeter0.61.54.01.11.11.1-2.00.70.71.3-1.60.7-1.41.60.6-1.50.11.1
Epididymis fat weight0.00.10.3-0.2-0.3-0.3-0.5-0.1-0.10.2-0.4-0.4-0.10.4-0.2-0.3-0.60.3
Delta time in closed arm before/after self-admin0.50.41.0-0.6-0.8-0.81.0-0.7-0.7-1.00.8-0.40.8-0.5-0.40.3-0.50.1
Delta time in open arm before/after self-admin2.52.97.11.51.81.8-2.71.81.82.5-2.60.6-1.70.90.5-0.81.9-0.1
Diff in mean of infusions in LGA sessions0.20.40.90.80.60.6-0.90.60.60.9-1.00.6-0.50.30.3-0.30.80.2
Delay discount exponential model param0.20.20.6-0.10.30.3-0.80.30.30.7-0.7-0.5-0.4-0.3-0.30.30.3-0.8
Extinction: sum of active levers before priming1.21.84.4-1.1-1.5-1.52.1-1.4-1.4-2.01.9-0.61.6-1.1-0.60.6-0.80.2
Active lever presses in extinction session 60.90.93.2-0.7-0.8-0.81.4-0.7-0.7-1.51.80.00.40.10.4-0.3-1.80.6
Bone: final force0.20.31.40.20.20.2-1.2-0.0-0.01.0-1.2-0.3-0.40.0-0.30.10.6-0.5
Bone: final moment0.20.21.10.00.00.0-1.0-0.3-0.30.7-1.1-0.4-0.2-0.1-0.50.10.5-0.4
Food consumed during 24 hour testing period3.97.911.83.33.23.2-3.42.82.83.4-3.42.7-2.52.21.8-1.92.91.7
Glucose0.20.20.8-0.5-0.1-0.1-0.70.20.20.7-0.5-0.7-0.3-0.2-0.50.4-0.5-0.9
Heart weight0.61.03.1-0.4-1.0-1.01.8-0.6-0.6-1.71.3-0.11.6-1.0-0.40.50.50.5
Delay discount hyperbolic model param0.20.31.0-0.30.20.2-0.80.20.20.8-0.8-0.7-0.4-0.4-0.50.40.3-1.0
Intermittent access intake day 1-15 change0.52.83.61.91.91.9-1.51.81.81.3-1.21.9-1.81.91.7-1.90.61.6
Intermittent access intake escalation0.31.62.21.51.41.4-1.11.31.30.9-0.91.5-1.31.51.3-1.50.51.3
Intermittent access intake escalation 21.22.12.61.61.61.6-1.21.61.61.2-0.91.6-1.51.61.5-1.60.71.5
Intermitt. access day 1 inactive lever presses0.10.73.30.30.50.50.10.40.4-0.10.80.8-1.01.11.2-1.1-1.80.9
Intermitt. access day 15 inactive lever presses0.20.91.3-1.1-1.0-1.00.6-1.1-1.1-0.60.5-1.10.8-0.6-1.01.1-0.6-1.0
Intermitt. access escalation Index0.10.31.3-0.2-0.5-0.51.1-0.3-0.3-0.81.10.30.4-0.00.2-0.1-0.40.5
Intermittent access day 1 total infusions1.02.93.8-1.9-1.9-1.91.4-1.9-1.9-1.41.1-1.91.7-1.7-1.71.8-1.2-1.6
Intermittent access day 15 total infusions0.30.71.0-0.9-0.9-0.90.8-1.0-1.0-0.90.8-0.70.8-0.7-0.70.7-0.8-0.6
Intermittent access terminal intake (last 3 days)0.40.71.1-1.0-0.9-0.90.8-1.0-1.0-0.80.8-0.90.7-0.7-0.70.7-1.0-0.7
Intermittent access total infusions1.11.31.8-1.3-1.3-1.30.8-1.3-1.3-0.90.7-1.41.0-1.2-1.11.2-0.7-1.2
Intermittent access day 1 locomotion1.01.82.4-1.5-1.5-1.51.5-1.5-1.5-1.51.4-1.11.5-1.1-1.01.1-1.1-0.8
Intermittent access day 15 total locomotion0.41.42.5-1.3-1.2-1.20.7-1.2-1.2-0.70.4-1.51.2-1.6-1.41.4-0.2-1.4
Intermittent access total locomotion1.82.13.5-1.6-1.5-1.50.9-1.5-1.5-0.90.5-1.81.6-1.9-1.81.8-0.0-1.8
Intermittent access standard deviation0.10.71.90.80.80.8-0.50.80.80.5-0.21.0-0.91.41.0-1.1-0.31.0
Left kidney weight0.54.16.02.42.02.0-2.42.12.12.2-2.31.8-1.82.11.4-2.11.62.0
Right kidney weight0.43.07.01.81.51.5-2.71.71.72.2-2.60.9-1.31.50.5-1.51.81.5
Cocaine induced anxiety0.20.51.9-0.6-0.5-0.51.1-0.5-0.5-1.11.4-0.10.30.10.2-0.1-1.30.3
Post-drug Anxiety0.30.40.7-0.6-0.6-0.60.8-0.7-0.7-0.80.7-0.50.7-0.5-0.40.4-0.4-0.3
Baseline Anxiety0.30.52.60.30.20.2-0.70.10.10.7-1.2-0.30.2-0.8-0.70.61.6-0.5
Tail length1.910.414.73.43.63.6-3.03.53.53.0-2.13.4-3.83.83.5-3.50.52.5
Length with tail0.93.87.21.72.22.2-2.72.02.02.3-2.11.3-2.52.31.6-2.00.30.9
Length without tail0.10.72.0-0.8-0.4-0.4-0.9-0.6-0.60.6-1.1-1.40.3-0.7-1.20.80.2-1.2
Times rat made contact with spout0.10.10.40.40.10.10.2-0.0-0.0-0.10.10.40.1-0.10.2-0.10.60.3
Lifetime Intake0.70.91.3-1.1-1.0-1.00.7-1.0-1.0-0.70.7-1.20.8-0.9-0.90.9-0.9-1.0
Liver weight, left0.40.71.60.70.90.9-1.10.80.81.2-0.60.4-1.30.80.8-0.9-0.20.3
Liver weight, right0.81.42.70.91.21.2-1.31.21.21.2-0.80.7-1.51.61.1-1.5-0.51.0
Locomotor activity0.50.71.7-0.4-0.2-0.2-0.6-0.7-0.70.2-1.1-0.90.8-1.1-1.31.11.2-1.1
Locomotor testing distance0.30.81.7-0.4-0.3-0.3-0.4-0.8-0.80.2-0.9-0.90.8-1.1-1.21.21.1-1.3
Locomotor testing rearing0.51.86.91.71.31.3-1.71.11.11.5-2.21.0-0.40.50.1-0.42.60.7
Locomotion in novel chamber0.40.62.3-0.0-0.4-0.4-0.4-0.5-0.50.2-1.0-0.50.8-1.0-1.10.91.5-0.6
Locomotion in novel chamber post-restriction0.20.61.10.70.90.9-0.40.90.90.6-0.00.8-1.00.91.1-0.8-0.20.5
Fecal boli incidents, locomotor time 10.51.43.40.81.21.2-1.61.11.11.2-1.10.6-1.81.80.9-1.4-0.40.7
Change in fecal boli incidents, locomotor task1.01.13.21.20.80.80.50.90.9-0.10.61.8-0.40.81.6-1.2-0.11.6
Time >=10cm from walls, locomotor time 10.10.10.30.50.30.30.10.40.40.0-0.10.60.1-0.10.30.00.6-0.1
Bouts of movement, locomotor time 10.30.41.6-0.6-0.4-0.40.8-0.6-0.6-1.01.0-0.10.30.40.2-0.1-1.30.1
Total resting periods, locomotor time 10.80.92.7-1.0-0.8-0.81.2-1.0-1.0-1.51.4-0.30.60.40.1-0.0-1.60.2
Rest time, locomotor task time 10.61.01.8-1.3-1.0-1.00.9-1.3-1.3-1.41.1-1.00.70.1-0.60.2-1.2-0.1
Distance moved, locomotor task time 10.20.41.60.30.10.1-0.30.40.40.8-0.8-0.10.2-1.1-0.50.81.3-0.9
Vertical activity count, locomotor time 10.64.28.82.32.32.3-2.42.52.53.0-2.71.5-1.60.40.8-0.42.6-0.2
Time >=10cm from walls, locomotor time 20.20.63.0-0.8-0.6-0.60.6-0.6-0.6-0.20.5-0.90.5-1.0-0.61.3-0.2-1.7
Bouts of movement, locomotor time 20.10.41.5-0.3-0.5-0.51.2-0.5-0.5-1.11.10.20.8-0.40.10.3-0.20.3
Total resting periods, locomotor time 20.00.20.7-0.1-0.2-0.20.8-0.2-0.2-0.70.70.30.6-0.20.20.20.10.3
Rest time, locomotor task time 20.10.20.50.40.40.4-0.50.10.10.2-0.40.3-0.30.70.2-0.40.20.6
Distance moved, locomotor task time 21.52.04.1-1.5-1.4-1.41.0-1.2-1.2-0.70.6-1.71.4-2.0-1.71.90.1-2.0
Vertical activity count, locomotor time 20.71.54.11.11.21.2-1.71.41.41.9-2.00.3-0.70.1-0.20.21.9-0.6
Light reinforcement 14.620.729.85.05.05.0-5.55.25.25.3-5.13.8-4.53.93.1-3.73.72.9
Light reinforcement 25.412.320.43.64.14.1-4.53.93.94.5-4.12.6-3.92.72.4-2.62.41.5
Bone: marrow area0.40.93.40.90.80.8-1.70.50.51.3-1.80.3-0.60.3-0.1-0.31.30.0
Bone: maximum diameter0.10.20.7-0.1-0.4-0.4-0.5-0.5-0.5-0.1-0.2-0.2-0.20.7-0.1-0.7-0.90.7
Bone: maximum force0.10.20.9-0.1-0.1-0.1-0.9-0.1-0.10.9-0.9-0.5-0.3-0.0-0.40.20.1-0.7
Bone: maximum moment0.10.20.6-0.2-0.2-0.2-0.8-0.3-0.30.6-0.8-0.6-0.1-0.1-0.50.20.1-0.5
Mean time between licks in bursts0.00.21.80.60.10.10.10.30.3-0.30.00.50.30.30.1-0.70.31.4
Mean num. licks in bursts0.10.41.5-0.7-0.2-0.21.0-0.4-0.4-0.71.2-0.1-0.1-0.10.40.2-1.2-0.5
Cd content in liver3.23.67.3-1.8-2.4-2.41.6-2.0-2.0-2.11.0-2.12.7-1.9-2.41.5-0.0-0.4
Co content in liver3.64.28.1-2.2-2.4-2.42.5-2.2-2.2-2.82.6-1.81.9-1.4-1.40.9-1.9-0.2
Cu content in liver0.50.51.3-0.8-0.9-0.90.2-0.8-0.8-0.5-0.0-1.11.0-0.7-1.20.60.2-0.2
Fe content in liver1.01.25.70.10.60.60.30.60.60.01.10.9-1.61.31.8-1.1-2.40.2
K content in liver0.70.71.1-1.1-1.0-1.00.8-0.8-0.8-0.60.8-0.90.5-0.6-0.60.7-1.0-1.0
Mg content in liver0.30.31.7-0.8-0.5-0.50.6-0.5-0.5-0.50.8-0.50.0-0.1-0.10.1-1.3-0.4
Mn content in liver0.20.30.80.60.30.3-0.90.20.20.6-0.90.2-0.20.5-0.1-0.60.50.8
Na content in liver0.20.20.60.30.40.4-0.30.40.40.6-0.10.5-0.80.50.6-0.1-0.6-0.5
Rb content in liver0.40.40.80.70.60.6-0.50.90.90.6-0.40.7-0.50.80.6-0.60.10.8
Se content in liver1.01.16.0-0.10.60.6-0.70.50.50.50.20.4-1.71.61.3-1.4-2.50.3
Sr content in liver1.00.91.8-1.2-0.9-0.90.6-1.1-1.1-0.90.5-1.41.0-0.9-1.20.8-0.5-0.6
Zn content in liver1.31.52.1-1.4-1.3-1.31.0-1.5-1.5-1.20.8-1.41.4-1.2-1.41.1-0.5-1.0
Bone: minimum diameter1.01.94.71.51.41.4-2.21.11.11.7-2.01.0-1.51.20.8-1.31.00.9
Time in familiar zone, hab. session 10.70.82.21.20.60.6-0.11.21.20.2-0.11.2-0.30.80.8-1.00.71.5
Time in novel zone, hab. session 11.01.12.5-1.2-0.8-0.81.1-1.2-1.2-0.80.9-0.90.8-1.2-0.61.3-0.4-1.6
Total zone transitions, hab. session 10.30.41.30.60.70.7-0.90.20.20.9-1.10.4-0.40.10.1-0.00.9-0.1
Total locomotion distance, hab. session 10.10.10.60.20.40.4-0.6-0.1-0.10.4-0.70.2-0.1-0.1-0.10.20.5-0.3
Locomotion velocity, hab. session 10.20.31.30.40.60.6-1.0-0.0-0.00.8-1.10.2-0.40.2-0.0-0.00.7-0.2
Time in familiar zone, hab. session 21.41.62.51.61.21.2-1.11.51.51.2-1.01.3-1.11.11.1-1.31.11.4
Time in novel zone, hab. session 23.13.44.8-2.0-1.9-1.91.4-2.1-2.1-1.50.9-2.02.1-2.2-2.12.2-0.1-1.9
Total zone transitions, hab. session 20.81.01.91.31.11.1-1.00.60.60.8-1.11.1-0.60.80.6-1.01.01.4
Total locomotion distance, hab. session 20.40.51.80.60.70.7-1.20.30.30.9-1.30.2-0.30.3-0.1-0.31.10.3
Locomotion velocity, hab. session 20.40.62.00.60.80.8-1.40.40.41.1-1.40.2-0.50.4-0.0-0.31.00.2
Novel to familiar place preference ratio0.50.71.5-0.7-0.6-0.60.7-0.8-0.8-0.80.3-0.71.2-1.0-1.01.10.3-0.7
Novelty place preference0.50.71.6-0.7-0.5-0.50.6-0.7-0.7-0.50.1-0.71.2-1.1-1.11.30.6-0.9
Time in novel zone, NPP test0.80.92.0-0.9-0.7-0.71.0-0.9-0.9-0.90.5-0.81.3-1.3-1.01.40.3-1.1
Total zone transitions, NPP test0.71.12.81.10.90.9-1.70.70.71.3-1.60.6-0.81.00.3-1.00.91.0
Total locomotion distance, NPP test0.10.10.50.40.30.3-0.70.00.00.4-0.70.2-0.10.3-0.1-0.30.60.4
Locomotion velocity, NPP test0.20.31.40.30.40.4-1.20.10.10.7-1.2-0.1-0.20.4-0.3-0.40.50.5
Intraocular pressure1.93.14.7-1.9-2.2-2.22.2-1.8-1.8-2.02.0-1.51.9-1.5-1.31.4-1.1-1.0
Delta distance traveled before/after self-admin0.10.10.30.40.50.5-0.30.30.30.2-0.40.4-0.20.30.3-0.20.40.2
Delta ambulatory time before/after self-admin0.50.81.31.11.11.1-0.60.90.90.5-0.61.2-0.71.00.9-1.00.41.0
Parametrial fat weight0.40.82.40.60.90.9-1.50.90.91.4-1.5-0.1-0.70.0-0.1-0.31.20.2
Pavlov. Cond. lever latency0.40.53.90.70.50.5-0.30.70.70.5-0.80.20.5-0.7-0.40.42.0-0.0
Pavlov. Cond. magazine entry latency0.70.92.6-1.0-1.0-1.01.3-0.9-0.9-1.21.6-0.30.3-0.10.10.2-1.6-0.2
Pavlov. Cond. change in total contacts0.60.73.80.00.10.10.0-0.1-0.1-0.20.60.5-0.91.31.1-1.1-2.00.8
Pavlov. Cond. index score0.91.14.8-1.1-1.1-1.11.1-1.1-1.1-1.21.6-0.50.10.20.1-0.1-2.2-0.1
Pavlov. Cond. latency score0.60.73.5-0.9-0.9-0.90.7-1.0-1.0-0.91.1-0.4-0.00.30.1-0.2-1.9-0.0
Pavlov. Cond. lever contacts0.70.95.1-1.0-0.8-0.80.8-1.0-1.0-0.91.3-0.4-0.20.40.3-0.1-2.3-0.3
Pavlov. Cond. magazine entry number1.62.05.81.71.51.5-1.81.41.41.7-2.10.9-0.60.40.2-0.62.40.7
Pavlov. Cond. intertrial magazine entries0.30.31.50.00.10.1-0.30.20.20.00.10.0-0.50.90.4-1.0-1.21.0
Pavlov. Cond. lever-magazine prob. diff.1.41.76.2-1.5-1.5-1.51.4-1.5-1.5-1.51.8-0.90.3-0.1-0.20.3-2.5-0.5
Pavlov. Cond. response bias1.21.56.8-1.3-1.1-1.11.6-1.1-1.1-1.52.1-0.30.10.10.40.0-2.6-0.3
Pavlov. Cond. lever latency0.20.30.7-0.6-0.6-0.60.1-0.5-0.5-0.10.0-0.80.4-0.7-0.70.50.3-0.7
Pavlov. Cond. magazine entry latency0.00.10.30.1-0.2-0.2-0.1-0.4-0.4-0.1-0.10.00.10.1-0.1-0.2-0.10.5
Pavlov. Cond. change in total contacts0.10.30.90.40.30.30.50.40.4-0.30.70.9-0.30.70.8-0.6-0.70.9
Pavlov. Cond. index score0.10.20.50.40.30.30.10.30.3-0.10.30.7-0.30.60.7-0.5-0.50.7
Pavlov. Cond. latency score0.10.20.50.40.40.40.10.30.3-0.00.30.7-0.40.70.7-0.6-0.60.7
Pavlov. Cond. lever contacts0.20.30.80.70.60.6-0.20.60.60.3-0.20.9-0.40.60.6-0.50.10.8
Pavlov. Cond. magazine entry number0.00.00.3-0.0-0.0-0.00.1-0.0-0.0-0.0-0.1-0.20.2-0.3-0.20.30.5-0.3
Pavlov. Cond. intertrial magazine entries1.32.73.71.91.91.9-1.81.71.71.7-1.71.5-1.51.61.3-1.61.31.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.30.10.10.30.20.2-0.20.40.6-0.20.50.5-0.4-0.50.6
Pavlov. Cond. response bias0.00.10.20.30.20.2-0.10.20.20.1-0.00.4-0.20.30.3-0.2-0.20.4
Time in closed arm before self-admin0.71.12.40.90.90.9-0.10.90.90.10.41.4-1.11.51.5-1.4-0.81.5
Time in closed arm after self-admin0.40.41.60.40.20.20.40.20.2-0.40.60.9-0.31.00.8-0.9-0.81.3
Time in open arm before self-admin0.70.81.4-0.8-1.1-1.11.1-1.0-1.0-1.10.8-0.71.2-1.2-0.80.90.1-0.4
Time in open arm after self-admin0.30.41.4-0.4-0.4-0.4-0.2-0.2-0.20.2-0.5-0.70.3-0.8-0.80.80.7-1.2
Bone: periosteal estimation0.41.03.91.00.70.7-1.90.50.51.4-2.00.4-0.70.6-0.0-0.71.20.5
Bone: periosteal perimeter0.40.72.10.90.40.4-1.50.30.30.8-1.20.4-0.61.20.1-1.30.21.3
Bone: post-yield work0.40.71.50.61.01.0-1.10.90.91.1-1.20.4-0.80.20.4-0.11.0-0.3
Progressive ratio test 1 active lever presses0.81.32.1-1.3-1.3-1.30.7-1.3-1.3-0.70.6-1.41.1-1.3-1.21.3-0.7-1.4
Progressive ratio test 1 breakpoint0.91.52.3-1.4-1.4-1.40.8-1.4-1.4-0.70.7-1.51.1-1.3-1.31.4-0.7-1.5
Progressive ratio test 1 inactive lever presses0.20.61.2-1.0-0.8-0.80.5-0.8-0.8-0.50.8-0.90.4-0.5-0.50.7-1.1-1.0
Progressive ratio test 2 active lever presses1.01.42.0-1.3-1.3-1.30.7-1.3-1.3-0.80.5-1.41.2-1.4-1.31.3-0.5-1.3
Progressive ratio test 2 breakpoint1.21.52.2-1.4-1.3-1.30.8-1.4-1.4-0.90.6-1.51.2-1.4-1.31.4-0.5-1.3
Progressive ratio test 2 inactive lever presses0.82.53.3-1.8-1.8-1.81.4-1.8-1.8-1.41.1-1.71.7-1.7-1.61.7-0.8-1.5
Incentive Sensitization - Responses0.10.20.3-0.5-0.5-0.50.2-0.5-0.5-0.30.0-0.60.5-0.5-0.60.60.0-0.5
Incentive Sensitization - Breakpoint0.10.10.2-0.4-0.4-0.40.1-0.4-0.4-0.2-0.1-0.50.4-0.4-0.50.50.1-0.4
Sum of active levers in priming session hrs 5-60.20.21.70.40.20.2-0.40.20.20.5-0.70.10.2-0.5-0.30.31.3-0.2
Progressive ratio0.30.82.31.00.90.9-1.30.90.91.3-1.50.4-0.50.30.0-0.31.50.2
Food seeking constrained by brief footshock1.72.12.91.41.71.7-1.51.71.71.3-1.11.2-1.61.71.3-1.70.11.3
Seeking ratio, punishment vs. effort0.20.40.80.20.60.6-0.40.50.50.20.10.3-0.90.90.8-0.8-0.90.4
Retroperitoneal fat weight0.20.83.90.10.20.2-1.90.10.11.1-2.0-0.8-0.10.1-0.9-0.21.00.3
Reaction time number correct0.41.32.9-1.1-1.2-1.21.6-1.4-1.4-1.71.7-0.50.9-0.4-0.30.2-1.40.3
Reaction time mean minus median0.21.32.2-1.4-1.2-1.20.9-1.1-1.1-0.70.9-1.50.8-1.4-1.11.2-0.4-1.5
Reaction time mean minus median AUC0.42.74.3-2.0-1.9-1.91.3-1.8-1.8-1.31.2-2.11.3-1.7-1.61.5-0.9-1.7
Reaction time num false alarms1.52.65.2-1.5-1.9-1.91.1-2.1-2.1-1.70.6-1.72.3-1.4-2.11.3-0.1-0.5
Reaction time num false alarms AUC1.02.24.5-1.4-1.8-1.81.4-1.9-1.9-2.01.0-1.32.1-1.0-1.60.9-0.5-0.1
Reaction time trials correct on left0.41.32.9-1.1-1.2-1.21.6-1.4-1.4-1.71.7-0.50.9-0.4-0.30.2-1.40.3
Reaction time trials on left0.41.43.1-1.2-1.3-1.31.6-1.5-1.5-1.71.7-0.71.1-0.6-0.50.4-1.40.2
Reaction time mean2.75.98.2-2.8-2.9-2.92.0-2.6-2.6-2.01.6-2.92.4-2.7-2.52.5-0.8-2.4
Reaction time mean AUC2.35.57.7-2.7-2.8-2.82.0-2.5-2.5-1.91.6-2.72.3-2.6-2.42.4-0.8-2.3
Median of all reaction times3.86.08.4-2.8-2.9-2.92.1-2.6-2.6-2.11.7-2.82.5-2.6-2.52.4-0.9-2.2
Reaction time omissions2.03.35.8-1.9-2.0-2.00.8-2.0-2.0-1.10.3-2.42.0-2.2-2.42.00.4-1.9
Reaction time false alarm rate0.40.61.5-0.7-0.9-0.90.5-1.0-1.0-0.90.2-0.81.2-0.5-1.00.60.0-0.1
Reaction time premature initiation rate5.18.010.93.32.92.9-2.63.13.12.8-2.13.0-3.12.92.8-3.01.42.6
Reaction time premature initiations1.44.26.12.42.02.0-1.62.12.11.7-1.22.4-2.22.32.2-2.50.82.4
Std. dev. reaction times0.72.33.5-1.8-1.8-1.81.1-1.5-1.5-1.00.9-1.91.3-1.8-1.51.6-0.4-1.8
Reaction time trials completed0.41.43.1-1.2-1.3-1.31.6-1.5-1.5-1.71.7-0.71.1-0.6-0.50.4-1.40.2
Reaction time trials AUC0.51.63.1-1.3-1.4-1.41.6-1.6-1.6-1.81.6-0.81.2-0.7-0.60.5-1.30.0
Run reversals in cocaine runway, females1.61.85.2-1.1-0.9-0.9-0.6-1.0-1.00.7-1.0-1.90.7-1.7-1.91.81.1-2.3
Run reversals in cocaine runway, males0.91.01.7-1.0-1.3-1.31.2-1.1-1.1-1.10.9-0.81.2-1.0-0.91.0-0.3-0.7
Latency to leave start box in cocaine runway0.81.12.7-0.8-0.7-0.7-0.4-0.7-0.70.3-0.9-1.50.9-1.3-1.61.51.1-1.6
Latency to leave start box in cocaine runway, F1.01.23.6-1.2-0.9-0.90.3-0.9-0.9-0.30.0-1.50.9-1.6-1.41.60.1-1.9
Latency to leave start box in cocaine runway, M0.60.62.90.60.30.3-1.30.20.21.0-1.6-0.1-0.10.1-0.40.11.7-0.0
Std. dev. time between licks in bursts0.61.22.61.61.01.0-1.00.90.90.9-1.11.3-0.61.00.7-1.21.21.6
Total sessions with >9 infusions1.92.45.5-1.8-1.5-1.51.9-1.6-1.6-1.92.2-1.21.2-0.9-0.60.8-2.4-0.6
Short access day 1 total inactive lever presses0.20.32.0-0.7-0.2-0.2-0.3-0.2-0.20.7-0.0-1.0-0.2-0.3-0.50.7-0.4-1.4
Short access day 10 total inactive lever presses0.32.03.41.41.51.5-0.81.51.50.8-0.31.7-1.71.81.8-1.8-0.41.6
Short access day 1 total infusions1.63.17.9-2.1-1.7-1.72.2-1.6-1.6-1.92.7-1.61.1-0.9-0.61.0-2.8-1.0
Short access day 10 total infusions0.50.91.5-1.1-1.1-1.10.8-1.1-1.1-1.00.9-1.00.8-0.8-0.70.7-1.2-0.7
Short access total infusions1.01.42.2-1.5-1.3-1.31.2-1.3-1.3-1.21.3-1.31.0-1.0-0.81.0-1.5-1.0
Short access day 1 locomotion2.23.65.9-2.3-2.0-2.02.2-1.9-1.9-2.02.4-1.81.6-1.4-1.11.4-2.4-1.3
Short access day 10 total locomotion0.31.33.0-1.1-1.2-1.21.7-1.3-1.3-1.71.5-0.51.5-0.8-0.60.7-0.6-0.1
Short access total locomotion1.82.85.0-1.9-1.8-1.82.2-1.7-1.7-2.12.2-1.31.7-1.3-1.01.2-1.5-0.8
One hour access (0.3 mA shock)0.70.91.2-1.0-1.0-1.00.7-1.1-1.1-0.80.4-1.01.1-1.0-1.11.1-0.3-1.0
Compulsive drug intake0.50.71.70.20.10.10.90.10.1-0.91.20.9-0.30.91.0-1.0-1.31.3
One hour access (shock baseline)0.41.12.3-0.9-0.9-0.90.2-1.0-1.0-0.2-0.3-1.41.1-1.5-1.51.50.6-1.5
Social response proportion0.60.82.0-0.7-0.8-0.8-0.0-0.6-0.6-0.2-0.4-1.21.0-1.3-1.41.00.9-1.0
Social responses0.30.43.10.5-0.0-0.0-0.20.00.0-0.1-0.70.10.9-0.6-0.80.21.80.4
Social time0.40.62.00.80.60.60.20.70.7-0.10.31.1-0.41.01.0-1.00.11.4
Soleus weight0.10.21.10.1-0.2-0.2-0.1-0.3-0.30.0-0.4-0.30.7-0.6-0.60.51.0-0.1
Bone: stiffness0.40.82.80.10.20.2-1.60.20.21.6-1.7-0.5-0.6-0.2-0.50.50.9-1.3
Tibialis anterior weight0.20.71.1-0.9-1.0-1.00.7-1.0-1.0-1.00.7-0.90.9-0.5-0.80.3-0.8-0.0
Time to tail flick, vehicle, before self-admin0.40.40.70.80.80.8-0.60.80.80.7-0.60.7-0.60.60.6-0.40.60.3
Time to tail flick, vehicle, after self-admin0.50.93.31.20.80.8-1.20.90.91.3-1.50.7-0.40.20.1-0.21.8-0.1
Time to tail flick, test, before self-admin2.73.05.8-2.3-1.8-1.81.1-1.7-1.7-1.10.8-2.41.6-1.9-2.02.1-0.7-2.1
Time to tail flick, test, after self-admin0.00.00.10.10.10.1-0.10.20.20.2-0.30.00.1-0.0-0.10.10.3-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.20.20.10.1-0.40.20.20.4-0.5-0.0-0.1-0.1-0.20.00.3-0.2
Delta time to tail flick, test, before/after SA0.20.31.00.60.40.40.20.30.3-0.10.20.9-0.10.50.6-0.7-0.01.0
Tibia length0.10.41.70.00.40.4-0.40.50.50.80.10.2-1.30.50.8-0.4-1.2-0.6
Ambulatory time before self-admin0.62.02.9-1.7-1.6-1.61.3-1.5-1.5-1.31.2-1.61.2-1.4-1.21.4-1.0-1.3
Ambulatory time after self-admin0.20.20.4-0.6-0.4-0.40.5-0.5-0.5-0.50.5-0.50.5-0.6-0.40.6-0.3-0.5
Bone: tissue strength1.11.12.7-1.4-1.3-1.30.9-1.1-1.1-1.01.0-1.20.7-0.6-0.80.5-1.6-0.6
Total heroin consumption0.20.21.00.0-0.3-0.3-0.1-0.3-0.30.0-0.4-0.30.6-0.7-0.60.51.0-0.3
Bone: trabecular number4.07.515.03.03.03.0-1.13.03.01.5-0.43.8-3.23.03.9-3.0-0.12.5
Bone: trabecular spacing3.34.88.5-2.4-2.4-2.41.2-2.5-2.5-1.40.6-2.92.6-2.4-2.92.4-0.0-1.9
Bone: trabecular thickness0.71.01.81.01.31.3-0.91.01.00.9-0.71.1-1.30.81.2-0.80.40.3
Bone: trabecular tissue density1.93.36.9-1.9-1.9-1.90.8-1.5-1.5-0.50.2-2.31.7-2.4-2.32.50.4-2.6
Water consumed over 24 hours0.50.91.71.31.21.2-0.80.90.90.9-1.01.2-0.60.60.8-0.51.30.6
Number of responses in last shaping day1.01.25.3-0.9-0.8-0.81.7-0.7-0.7-1.52.2-0.10.40.20.4-0.2-2.30.4