Hub : Genes

Gadd45gip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Gadd45gip1 0.07 0.04 1.8e-07 0.02 0.03 0.04 0.04 2.6e-04 5.6e-06 1.8e-07 1.7e-06
2 Brain mRNA stability Gadd45gip1 0.19 0.08 2.1e-12 0.15 0.11 0.13 0.13 8.1e-14 2.0e-10 4.9e-12 2.9e-12
3 IL mRNA stability Gadd45gip1 0.23 0.12 3.6e-03 0.04 0.02 0.03 0 3.1e-02 1.1e-01 7.8e-02 2.8e-01
4 IC mRNA stability Gadd45gip1 0.18 0.1 6.5e-04 0.02 0.06 0.05 0.04 6.3e-02 2.2e-03 2.6e-03 1.2e-02
5 PL mRNA stability Gadd45gip1 0.14 0.07 1.5e-09 0.06 0.09 0.09 0.09 3.2e-07 8.1e-10 6.5e-10 1.6e-09
6 Liver mRNA stability Gadd45gip1 0.12 0.06 6.2e-10 0.09 0.08 0.08 0.09 1.8e-10 7.5e-09 1.9e-09 4.4e-10
7 Adipose mRNA stability Gadd45gip1 0.34 0.11 0.0e+00 0.25 0.23 0.24 0.15 1.3e-27 1.1e-25 6.8e-27 1.9e-16
8 pVTA mRNA stability Gadd45gip1 0.12 0.06 2.1e-05 0.04 0.05 0.04 0.04 6.7e-04 3.9e-05 1.7e-04 8.0e-04
9 Brain gene expression Gadd45gip1 0.08 0.04 1.4e-05 0.05 0.05 0.05 0.05 1.4e-05 1.9e-05 1.5e-05 2.4e-05
10 Liver gene expression Gadd45gip1 0.57 0.11 0.0e+00 0.42 0.41 0.42 0.42 5.1e-51 2.8e-48 9.2e-50 3.1e-51
11 RMTg gene expression Gadd45gip1 0.7 0.12 5.0e-16 0.4 0.23 0.45 0.28 1.1e-11 6.6e-07 2.2e-13 3.8e-08
12 Adipose gene expression Gadd45gip1 0.3 0.1 0.0e+00 0.21 0.2 0.21 0.21 8.4e-23 7.3e-22 2.3e-23 4.3e-23
13 IC gene expression Gadd45gip1 0.17 0.09 3.5e-05 0.09 0.11 0.08 0.07 1.4e-04 2.9e-05 2.9e-04 4.9e-04
14 BLA mRNA stability Gadd45gip1 0.13 0.07 4.9e-05 0.02 0.04 0.06 0.03 3.6e-02 5.4e-03 2.6e-04 6.5e-03
15 RMTg mRNA stability Gadd45gip1 0.27 0.13 1.1e-03 0.1 0.07 0.09 0.1 1.3e-03 5.7e-03 2.9e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density3.45.89.5-2.9-2.7-2.7-1.8-1.9-2.7-2.7-1.4-3.1-2.6-2.4-2.8-2.4-1.1-2.0
Area under the delay curve0.10.20.4-0.10.30.30.70.60.20.20.7-0.50.3-0.2-0.3-0.20.2-0.6
BMI with tail1.76.010.42.52.82.82.22.42.62.61.52.63.22.92.82.40.11.4
BMI without tail0.10.20.60.10.60.60.80.80.20.20.6-0.10.70.30.2-0.1-0.3-0.7
Body weight0.10.31.10.50.40.4-0.6-0.10.40.4-0.71.00.50.51.10.3-0.30.2
Weight adjusted by age0.30.50.70.80.70.70.80.80.80.80.80.70.70.60.40.60.60.5
Bone surface3.15.69.7-2.5-2.5-2.5-1.5-1.7-2.5-2.5-0.7-2.9-2.9-2.8-3.1-2.80.3-2.1
Bone volume3.35.99.9-2.6-2.7-2.7-1.8-1.9-2.5-2.5-1.0-2.9-3.1-2.9-3.1-2.80.2-2.0
Breakpoint value in progressive ratio session1.01.24.7-0.2-0.1-0.1-1.3-1.3-0.1-0.1-1.80.80.21.11.11.0-2.21.3
Number of licking bursts0.30.41.8-0.9-0.4-0.4-0.6-0.4-0.4-0.4-0.9-0.60.2-0.30.1-0.4-1.3-1.0
Context. condit. distance diff. score1.51.93.11.41.61.61.01.21.71.70.61.61.71.31.81.20.20.4
Locomotion velocity, session 11.51.62.2-1.4-1.4-1.4-1.3-1.3-1.1-1.1-1.0-1.3-1.5-1.3-1.3-1.3-0.5-1.2
Locomotion distance, session 10.40.51.9-0.7-0.6-0.6-1.2-0.8-0.3-0.3-1.4-0.3-0.1-0.20.2-0.3-1.3-0.6
Locomotion velocity, session 20.80.91.5-1.2-1.2-1.2-0.7-0.7-1.0-1.0-0.8-1.1-0.6-0.7-0.7-0.8-1.1-1.2
Locomotion distance, session 20.30.51.8-0.00.10.1-0.9-0.40.40.4-1.30.60.70.51.10.4-1.3-0.0
Locomotion velocity, session 30.10.10.50.20.20.20.50.40.20.20.6-0.10.0-0.2-0.2-0.20.7-0.3
Locomotion distance, session 31.01.15.2-1.0-0.4-0.40.30.4-0.6-0.60.6-1.5-0.5-1.4-1.3-1.70.6-2.3
Stereotopy head waving bouts, day 31.01.24.11.01.01.01.71.60.70.72.00.30.30.0-0.3-0.02.00.0
Stereotopy head waving duration, day 30.50.61.70.80.90.91.31.20.60.61.30.40.60.50.20.40.90.3
Locomotion velocity, session 70.20.20.50.20.50.50.50.60.30.30.40.20.70.20.4-0.0-0.1-0.7
Locomotion distance, session 70.30.41.5-0.7-0.5-0.5-0.9-0.8-0.5-0.5-1.0-0.4-0.1-0.20.0-0.3-1.2-0.7
Stereotopy head waving bouts, day 70.60.61.9-0.30.10.10.90.9-0.1-0.11.2-0.8-0.2-0.8-1.0-1.11.1-1.4
Stereotopy head waving duration, day 70.70.82.1-0.9-0.6-0.60.40.3-0.7-0.70.7-1.3-0.7-1.1-1.4-1.40.7-1.5
Locomotion velocity, session 80.20.21.0-0.1-0.1-0.1-1.0-0.70.30.3-1.00.3-0.1-0.10.60.0-0.60.1
Locomotion distance, session 80.60.82.60.40.80.8-0.30.21.01.0-0.81.01.30.91.60.7-1.2-0.1
Degree of sensitization distance0.80.81.80.3-0.1-0.1-1.0-1.0-0.0-0.0-1.31.00.20.91.11.1-1.31.3
Degree of sensitization stereotypy0.30.41.4-0.3-0.0-0.00.70.7-0.1-0.10.8-0.6-0.0-0.5-0.7-0.80.7-1.2
Conditioned locomotion0.10.10.4-0.2-0.3-0.3-0.6-0.5-0.2-0.2-0.5-0.1-0.4-0.4-0.1-0.3-0.0-0.1
Cocaine response after cond. corrected0.60.71.80.50.60.6-0.4-0.30.40.4-0.71.10.71.01.31.1-1.11.1
Cocaine response after cond. not corrected0.60.71.80.40.50.5-0.5-0.40.40.4-1.01.00.70.91.31.1-1.41.1
Cocaine response before conditioning0.30.41.0-0.7-0.7-0.7-0.3-0.2-0.5-0.5-0.2-0.9-0.5-0.7-0.7-0.7-0.1-1.0
Saline control response2.63.48.4-2.1-1.7-1.7-2.6-2.4-1.8-1.8-2.9-1.2-0.9-0.8-0.3-0.8-2.9-1.2
Bone: connectivity density5.89.115.7-3.6-3.3-3.3-1.7-2.1-3.5-3.5-1.2-4.0-3.0-3.2-3.6-3.2-1.1-2.9
Bone: cortical apparent density0.40.62.3-0.00.60.61.51.3-0.0-0.01.3-0.31.00.5-0.00.1-0.3-0.9
Bone: cortical area0.20.21.1-0.4-0.0-0.0-1.1-0.70.10.1-1.00.1-0.3-0.30.3-0.4-0.4-0.4
Bone: cortical porosity1.01.12.11.41.01.00.10.51.31.30.11.40.80.81.41.10.71.3
Bone: cortical porosity0.60.71.41.20.90.90.00.51.11.10.11.20.50.41.00.61.00.9
Bone: cortical thickness1.01.73.31.21.61.60.50.91.61.60.11.71.61.41.81.1-0.30.6
Bone: cortical thickness1.72.012.3-0.20.40.4-0.5-0.30.50.5-1.60.91.81.81.91.6-3.50.6
Bone: cortical tissue density0.40.62.2-0.10.50.51.51.2-0.1-0.11.3-0.40.90.4-0.1-0.1-0.2-1.0
Condit. Reinf. active minus inactive responses1.92.15.11.01.71.71.52.21.81.81.60.71.50.20.8-0.41.7-1.6
Condit. Reinf. active-inactive response ratio1.51.63.01.11.61.60.91.51.61.60.71.21.71.01.50.50.4-0.5
Condit. Reinf. active responses0.91.13.20.40.90.91.11.71.11.11.3-0.10.7-0.5-0.0-0.81.6-1.8
Condit. Reinf. inactive responses2.12.64.9-1.6-1.7-1.7-0.9-1.0-1.5-1.5-0.4-2.0-1.8-2.2-2.1-1.90.5-1.8
Incentive salience index mean1.01.35.0-0.00.50.50.81.40.80.81.2-0.60.1-1.2-0.7-1.51.9-2.2
Condit. Reinf. lever presses1.31.94.8-0.8-0.6-0.60.00.3-0.3-0.30.7-1.6-1.3-2.2-1.9-2.11.9-2.2
Condit. Reinf. active minus inactive responses0.20.20.7-0.2-0.3-0.3-0.4-0.3-0.3-0.3-0.1-0.3-0.6-0.9-0.4-0.70.6-0.5
Condit. Reinf. active-inactive response ratio0.10.20.50.60.30.3-0.00.10.40.40.10.60.10.20.40.30.50.7
Condit. Reinf. active responses0.10.20.5-0.4-0.5-0.5-0.7-0.6-0.4-0.4-0.6-0.2-0.4-0.6-0.1-0.4-0.1-0.3
Condit. Reinf. inactive responses0.10.20.8-0.1-0.2-0.2-0.5-0.6-0.1-0.1-0.80.20.10.30.50.5-0.90.2
Condit. Reinf. lever presses0.00.00.30.20.10.10.30.30.00.00.3-0.00.2-0.00.00.20.5-0.0
Condit. Reinf. lever reinforcers received0.10.10.2-0.2-0.4-0.4-0.4-0.4-0.3-0.3-0.4-0.2-0.4-0.4-0.2-0.20.1-0.2
Conditioned reinforcement - actives0.00.00.20.10.10.1-0.20.00.20.2-0.20.2-0.1-0.00.10.00.40.1
Conditioned reinforcement - inactives0.00.10.40.30.20.20.30.20.20.20.40.20.10.20.10.20.60.2
Conditioned locomotion0.00.10.30.10.10.10.40.30.10.10.5-0.10.1-0.1-0.2-0.10.6-0.2
Patch foraging indifference point 0 sec0.10.31.30.30.40.40.00.30.60.60.40.2-0.2-0.7-0.0-0.71.1-0.7
Patch foraging indifference point AUC1.72.54.0-1.7-2.0-2.0-1.7-1.9-2.0-2.0-1.6-1.4-1.5-1.2-1.2-0.9-1.3-0.4
Delay disc. indifference point, 0s delay1.21.32.6-1.4-1.2-1.2-0.7-0.8-1.2-1.2-0.3-1.6-1.4-1.2-1.6-1.30.0-0.8
Delay disc. indifference point, 16s delay0.80.92.10.71.01.00.70.50.90.90.20.91.21.41.11.3-0.61.1
Delay disc. indifference point, 2s delay0.80.91.80.81.01.01.31.41.11.11.30.30.90.40.20.41.00.2
Delay disc. indifference point, 24s delay0.30.30.60.70.80.80.50.60.50.50.50.70.60.20.60.30.6-0.1
Delay disc. indifference point, 4s delay0.90.92.9-1.1-0.5-0.50.40.2-0.5-0.50.7-1.7-0.6-1.2-1.5-1.20.5-1.5
Delay disc. indifference point, 8s delay0.20.20.8-0.10.20.20.70.70.20.20.7-0.50.4-0.4-0.3-0.30.1-0.9
Indifference point function ln k1.62.85.41.72.02.02.12.31.91.92.31.11.40.70.80.42.1-0.2
Indifference point function log k1.62.85.41.72.02.02.12.31.91.92.31.11.40.70.80.42.1-0.2
Patch foraging total patch changes 0 sec0.20.41.40.70.80.80.30.61.01.00.60.60.2-0.20.4-0.21.2-0.3
Patch foraging total patch changes 12 sec1.21.52.8-1.4-1.2-1.2-1.6-1.1-0.9-0.9-1.5-1.1-1.0-1.5-0.7-1.5-0.7-1.7
Patch foraging total patch changes 18 sec2.64.05.4-2.3-2.3-2.3-2.3-2.2-1.9-1.9-2.1-1.9-2.0-2.1-1.5-1.9-1.3-1.7
Patch foraging total patch changes 24 sec1.42.43.3-1.7-1.5-1.5-1.4-1.4-1.7-1.7-1.0-1.5-1.7-1.7-1.6-1.8-0.3-1.7
Patch foraging total patch changes 6 sec0.50.71.0-1.0-1.0-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.7-1.0-0.6-0.7-0.5-0.6
Patch foraging time to switch 0 sec0.00.10.4-0.3-0.0-0.0-0.5-0.30.10.1-0.7-0.00.0-0.00.2-0.1-0.5-0.1
Patch foraging water rate 0 sec0.00.10.40.3-0.2-0.2-0.2-0.2-0.1-0.1-0.10.4-0.10.20.20.30.20.6
Patch foraging water rate 12 sec0.30.62.80.30.50.51.61.30.40.41.7-0.30.6-0.0-0.4-0.10.8-0.5
Patch foraging water rate 18 sec0.91.43.2-0.5-0.2-0.21.20.9-0.5-0.51.8-1.4-0.6-1.2-1.7-1.41.7-1.7
Patch foraging water rate 24 sec0.50.72.70.20.40.41.41.20.10.11.7-0.50.1-0.4-0.6-0.61.4-1.1
Patch foraging water rate 6 sec3.14.56.2-2.5-2.4-2.4-2.1-2.1-2.5-2.5-1.8-2.3-2.1-1.9-1.9-1.8-1.5-1.5
Seeking ratio, delayed vs. immediate footshock1.31.62.81.11.51.51.71.71.41.41.20.81.61.21.01.00.30.3
Distance traveled before self-admin1.11.42.01.41.41.41.31.21.31.31.31.21.01.00.81.01.10.9
Distance traveled after self-admin1.11.32.01.41.11.11.31.41.21.21.21.21.11.10.91.10.80.9
Extensor digitorum longus weight0.31.12.71.00.90.9-0.5-0.30.90.9-0.91.60.91.11.61.2-0.61.3
Bone: elastic displacement0.60.71.50.90.90.90.91.11.01.01.10.60.60.30.40.11.2-0.0
Bone: elastic work1.82.43.91.81.91.91.11.42.02.00.91.81.51.41.71.20.91.1
Bone: endosteal estimation0.40.93.3-0.8-0.8-0.8-1.7-1.3-0.5-0.5-1.8-0.3-0.7-0.40.1-0.4-1.2-0.0
Bone: endosteal perimeter0.71.54.0-1.1-1.1-1.1-2.0-1.3-0.7-0.7-1.6-0.7-1.4-1.6-0.6-1.5-0.1-1.1
Epididymis fat weight0.00.10.30.20.30.3-0.5-0.20.10.1-0.40.4-0.1-0.40.2-0.30.6-0.3
Delta time in closed arm before/after self-admin0.50.41.00.60.80.81.01.00.70.70.80.40.80.50.40.30.5-0.1
Delta time in open arm before/after self-admin3.02.97.1-1.5-1.8-1.8-2.7-2.5-1.8-1.8-2.6-0.6-1.7-0.8-0.5-0.8-1.90.1
Diff in mean of infusions in LGA sessions0.30.40.9-0.8-0.6-0.6-0.9-0.9-0.6-0.6-1.0-0.6-0.5-0.3-0.3-0.3-0.8-0.2
Delay discount exponential model param0.20.20.60.1-0.3-0.3-0.8-0.7-0.3-0.3-0.70.5-0.40.30.30.3-0.30.8
Extinction: sum of active levers before priming1.71.84.41.11.51.52.12.01.41.41.90.61.61.10.60.60.8-0.2
Active lever presses in extinction session 60.90.93.20.70.80.81.41.50.70.71.8-0.00.4-0.1-0.4-0.31.8-0.6
Bone: final force0.20.31.4-0.2-0.2-0.2-1.2-1.00.00.0-1.20.3-0.40.00.30.1-0.60.5
Bone: final moment0.20.21.1-0.0-0.0-0.0-1.0-0.70.30.3-1.10.4-0.20.20.50.1-0.50.4
Food consumed during 24 hour testing period5.77.911.8-3.3-3.2-3.2-3.4-3.4-2.8-2.8-3.4-2.7-2.5-2.2-1.8-1.9-2.9-1.7
Glucose0.20.20.80.50.10.1-0.7-0.7-0.2-0.2-0.50.7-0.30.20.50.40.50.9
Heart weight0.71.03.10.41.01.01.81.70.60.61.30.11.60.90.40.5-0.5-0.5
Delay discount hyperbolic model param0.30.31.00.3-0.2-0.2-0.8-0.8-0.2-0.2-0.80.7-0.40.40.50.4-0.31.0
Intermittent access intake day 1-15 change1.42.83.6-1.9-1.9-1.9-1.5-1.3-1.8-1.8-1.2-1.9-1.8-1.9-1.7-1.9-0.6-1.6
Intermittent access intake escalation0.81.62.2-1.5-1.4-1.4-1.1-0.9-1.3-1.3-0.9-1.5-1.3-1.5-1.3-1.5-0.5-1.3
Intermittent access intake escalation 21.82.12.6-1.6-1.6-1.6-1.2-1.2-1.6-1.6-0.9-1.6-1.5-1.6-1.5-1.6-0.7-1.5
Intermitt. access day 1 inactive lever presses0.20.73.3-0.3-0.5-0.50.10.1-0.4-0.40.8-0.8-1.0-1.1-1.2-1.11.8-0.9
Intermitt. access day 15 inactive lever presses0.40.91.31.11.01.00.60.61.11.10.51.10.80.61.01.10.61.0
Intermitt. access escalation Index0.20.31.30.20.50.51.10.80.30.31.1-0.30.40.0-0.2-0.10.4-0.5
Intermittent access day 1 total infusions1.82.93.81.91.91.91.41.41.91.91.11.91.71.71.71.81.21.6
Intermittent access day 15 total infusions0.50.71.00.90.90.90.80.91.01.00.80.70.80.70.70.70.80.6
Intermittent access terminal intake (last 3 days)0.60.71.11.00.90.90.80.81.01.00.80.90.70.70.70.71.00.7
Intermittent access total infusions1.11.31.81.31.31.30.80.91.31.30.71.41.01.21.11.20.71.2
Intermittent access day 1 locomotion1.41.82.41.51.51.51.51.51.51.51.41.11.51.11.01.11.10.8
Intermittent access day 15 total locomotion0.81.42.51.31.21.20.70.71.21.20.41.51.21.61.41.40.21.4
Intermittent access total locomotion1.82.13.51.61.51.50.90.91.51.50.51.81.61.91.81.80.01.8
Intermittent access standard deviation0.30.71.9-0.8-0.8-0.8-0.5-0.5-0.8-0.8-0.2-1.0-0.9-1.4-1.0-1.10.3-1.0
Left kidney weight0.94.16.0-2.4-2.0-2.0-2.4-2.2-2.1-2.1-2.3-1.8-1.8-2.0-1.4-2.1-1.6-2.0
Right kidney weight0.73.07.0-1.8-1.5-1.5-2.7-2.2-1.7-1.7-2.6-0.9-1.3-1.5-0.5-1.5-1.8-1.5
Cocaine induced anxiety0.40.51.90.60.50.51.11.10.50.51.40.10.3-0.1-0.2-0.11.3-0.3
Post-drug Anxiety0.30.40.70.60.60.60.80.90.70.70.70.50.70.50.40.40.40.3
Baseline Anxiety0.40.52.6-0.3-0.2-0.2-0.7-0.7-0.1-0.1-1.20.30.20.80.70.6-1.60.5
Tail length2.710.414.7-3.4-3.6-3.6-3.0-3.0-3.5-3.5-2.1-3.4-3.8-3.8-3.5-3.5-0.5-2.5
Length with tail0.93.87.2-1.7-2.2-2.2-2.7-2.3-2.0-2.0-2.1-1.3-2.5-2.2-1.6-2.0-0.3-0.9
Length without tail0.20.72.00.80.40.4-0.9-0.60.60.6-1.11.40.30.71.20.8-0.21.2
Times rat made contact with spout0.10.10.4-0.4-0.1-0.10.20.10.00.00.1-0.40.10.1-0.2-0.1-0.6-0.3
Lifetime Intake0.70.91.31.11.01.00.70.71.01.00.71.20.80.90.90.90.91.0
Liver weight, left0.40.71.6-0.7-0.9-0.9-1.1-1.1-0.8-0.8-0.6-0.4-1.3-0.8-0.8-0.90.2-0.3
Liver weight, right0.81.42.6-0.9-1.2-1.2-1.3-1.2-1.2-1.2-0.8-0.7-1.5-1.6-1.1-1.50.5-1.0
Locomotor activity0.50.71.70.40.20.2-0.6-0.20.70.7-1.10.90.81.11.31.1-1.21.1
Locomotor testing distance0.40.81.70.40.30.3-0.4-0.20.80.8-0.90.90.81.11.21.2-1.11.3
Locomotor testing rearing0.91.86.9-1.7-1.3-1.3-1.7-1.5-1.1-1.1-2.2-1.0-0.4-0.5-0.1-0.4-2.6-0.7
Locomotion in novel chamber0.50.62.30.00.40.4-0.4-0.30.50.5-1.00.50.81.01.10.9-1.50.6
Locomotion in novel chamber post-restriction0.40.61.1-0.7-0.9-0.9-0.4-0.6-0.9-0.9-0.0-0.8-1.0-0.9-1.1-0.80.2-0.5
Fecal boli incidents, locomotor time 11.01.43.3-0.8-1.2-1.2-1.6-1.2-1.1-1.1-1.1-0.6-1.8-1.8-0.9-1.40.4-0.7
Change in fecal boli incidents, locomotor task1.11.13.2-1.2-0.8-0.80.50.1-0.9-0.90.6-1.8-0.4-0.8-1.6-1.20.1-1.6
Time >=10cm from walls, locomotor time 10.10.10.3-0.5-0.3-0.30.1-0.0-0.4-0.4-0.1-0.60.10.1-0.30.0-0.60.1
Bouts of movement, locomotor time 10.40.41.60.60.40.40.81.00.60.61.00.10.3-0.4-0.2-0.11.3-0.1
Total resting periods, locomotor time 10.80.92.71.00.80.81.21.51.01.01.40.30.6-0.4-0.1-0.01.6-0.2
Rest time, locomotor task time 10.81.01.81.31.01.00.91.41.31.31.11.00.7-0.10.60.21.20.1
Distance moved, locomotor task time 10.30.41.6-0.3-0.1-0.1-0.3-0.8-0.4-0.4-0.80.10.21.10.50.8-1.30.9
Vertical activity count, locomotor time 11.74.28.8-2.3-2.3-2.3-2.4-3.0-2.5-2.5-2.7-1.5-1.6-0.4-0.8-0.4-2.60.2
Time >=10cm from walls, locomotor time 20.40.63.00.80.60.60.60.20.60.60.50.90.51.00.61.30.21.7
Bouts of movement, locomotor time 20.20.41.50.30.50.51.21.00.50.51.1-0.20.80.4-0.10.30.2-0.3
Total resting periods, locomotor time 20.10.20.70.10.20.20.80.70.20.20.7-0.30.60.2-0.20.2-0.1-0.3
Rest time, locomotor task time 20.10.20.5-0.4-0.4-0.4-0.5-0.2-0.1-0.1-0.4-0.3-0.3-0.7-0.2-0.4-0.2-0.6
Distance moved, locomotor task time 21.72.04.01.51.41.41.00.71.21.20.61.71.42.01.71.9-0.12.0
Vertical activity count, locomotor time 21.11.54.1-1.1-1.2-1.2-1.7-1.9-1.4-1.4-2.0-0.3-0.7-0.10.20.2-1.90.6
Light reinforcement 18.420.729.8-5.0-5.0-5.0-5.5-5.3-5.2-5.2-5.1-3.8-4.5-3.9-3.1-3.7-3.7-2.9
Light reinforcement 28.012.320.5-3.6-4.1-4.1-4.5-4.5-3.9-3.9-4.1-2.6-3.9-2.7-2.4-2.6-2.4-1.5
Bone: marrow area0.40.93.4-0.9-0.8-0.8-1.7-1.3-0.5-0.5-1.8-0.3-0.6-0.30.1-0.3-1.3-0.0
Bone: maximum diameter0.10.20.70.10.40.4-0.50.10.50.5-0.20.2-0.2-0.70.1-0.70.9-0.7
Bone: maximum force0.10.20.90.10.10.1-0.9-0.90.10.1-0.90.5-0.30.00.40.2-0.10.7
Bone: maximum moment0.10.20.60.20.20.2-0.8-0.60.30.3-0.80.6-0.10.10.50.2-0.10.5
Mean time between licks in bursts0.10.21.8-0.6-0.1-0.10.10.3-0.3-0.30.0-0.50.3-0.2-0.1-0.7-0.3-1.4
Mean num. licks in bursts0.20.41.50.70.20.21.00.70.40.41.20.1-0.10.0-0.40.21.20.5
Cd content in liver3.33.67.31.82.42.41.62.22.02.01.02.12.72.02.41.50.00.4
Co content in liver3.64.28.22.22.42.42.52.92.22.22.61.81.91.51.40.91.90.2
Cu content in liver0.50.61.30.80.90.90.20.50.80.8-0.01.11.00.81.20.6-0.20.2
Fe content in liver1.01.25.7-0.1-0.6-0.60.3-0.0-0.6-0.61.1-0.9-1.6-1.4-1.8-1.12.4-0.2
K content in liver0.70.71.11.11.01.00.80.60.80.80.80.90.50.60.60.71.01.0
Mg content in liver0.30.31.70.80.50.50.60.50.50.50.80.50.00.10.10.11.30.4
Mn content in liver0.20.30.8-0.6-0.3-0.3-0.9-0.6-0.2-0.2-0.9-0.2-0.2-0.40.1-0.6-0.5-0.8
Na content in liver0.20.20.6-0.3-0.4-0.4-0.3-0.6-0.4-0.4-0.1-0.5-0.8-0.5-0.6-0.10.60.5
Rb content in liver0.40.40.8-0.7-0.6-0.6-0.5-0.6-0.9-0.9-0.4-0.7-0.5-0.8-0.6-0.6-0.1-0.8
Se content in liver1.01.16.00.1-0.6-0.6-0.7-0.5-0.5-0.50.2-0.4-1.7-1.6-1.3-1.42.5-0.3
Sr content in liver1.00.91.81.20.90.90.60.91.11.10.51.41.00.91.20.80.50.6
Zn content in liver1.41.52.11.41.31.31.01.21.51.50.81.41.41.31.41.10.51.0
Bone: minimum diameter1.01.94.7-1.5-1.4-1.4-2.2-1.7-1.1-1.1-2.0-1.0-1.5-1.2-0.8-1.3-1.0-0.9
Time in familiar zone, hab. session 10.80.82.2-1.2-0.6-0.6-0.1-0.2-1.2-1.2-0.1-1.2-0.3-0.8-0.8-1.0-0.7-1.5
Time in novel zone, hab. session 11.11.12.51.20.80.81.10.81.21.20.90.90.81.20.61.30.41.6
Total zone transitions, hab. session 10.30.41.3-0.6-0.7-0.7-0.9-0.9-0.2-0.2-1.1-0.4-0.4-0.1-0.1-0.0-0.90.1
Total locomotion distance, hab. session 10.10.10.6-0.2-0.4-0.4-0.6-0.50.10.1-0.7-0.2-0.10.00.10.2-0.50.3
Locomotion velocity, hab. session 10.20.31.3-0.4-0.6-0.6-1.0-0.80.00.0-1.1-0.2-0.4-0.20.0-0.0-0.70.2
Time in familiar zone, hab. session 21.51.62.5-1.6-1.2-1.2-1.1-1.2-1.5-1.5-1.0-1.3-1.1-1.1-1.1-1.3-1.1-1.4
Time in novel zone, hab. session 23.43.44.82.01.91.91.41.52.12.10.92.02.12.22.12.20.11.9
Total zone transitions, hab. session 20.81.01.9-1.3-1.1-1.1-1.0-0.8-0.6-0.6-1.1-1.1-0.6-0.8-0.6-1.0-1.0-1.4
Total locomotion distance, hab. session 20.40.51.8-0.6-0.7-0.7-1.2-0.9-0.3-0.3-1.3-0.2-0.3-0.30.1-0.3-1.1-0.3
Locomotion velocity, hab. session 20.40.62.0-0.6-0.8-0.8-1.4-1.1-0.4-0.4-1.4-0.2-0.5-0.40.0-0.3-1.0-0.2
Novel to familiar place preference ratio0.60.71.50.70.60.60.70.80.80.80.30.71.21.01.01.1-0.30.7
Novelty place preference0.60.71.60.70.50.50.60.50.70.70.10.71.21.11.11.3-0.60.9
Time in novel zone, NPP test0.90.92.00.90.70.71.00.90.90.90.50.81.31.21.01.4-0.31.1
Total zone transitions, NPP test0.71.12.8-1.1-0.9-0.9-1.7-1.3-0.7-0.7-1.6-0.6-0.8-1.0-0.3-1.0-0.9-1.0
Total locomotion distance, NPP test0.10.10.5-0.4-0.3-0.3-0.7-0.4-0.0-0.0-0.7-0.2-0.1-0.30.1-0.3-0.6-0.4
Locomotion velocity, NPP test0.20.31.4-0.3-0.4-0.4-1.2-0.7-0.1-0.1-1.20.1-0.2-0.40.3-0.4-0.5-0.5
Intraocular pressure2.13.14.71.92.22.22.22.01.81.82.01.51.91.61.31.41.11.0
Delta distance traveled before/after self-admin0.10.10.3-0.4-0.5-0.5-0.3-0.2-0.3-0.3-0.4-0.4-0.2-0.3-0.3-0.2-0.4-0.2
Delta ambulatory time before/after self-admin0.60.81.3-1.1-1.1-1.1-0.6-0.5-0.9-0.9-0.6-1.2-0.7-1.0-0.9-1.0-0.4-1.0
Parametrial fat weight0.40.82.4-0.6-0.9-0.9-1.5-1.4-0.9-0.9-1.50.1-0.70.00.1-0.3-1.2-0.2
Pavlov. Cond. lever latency0.40.53.9-0.7-0.5-0.5-0.3-0.5-0.7-0.7-0.8-0.20.50.70.40.4-2.00.0
Pavlov. Cond. magazine entry latency0.70.92.61.01.01.01.31.20.90.91.60.30.30.1-0.10.21.60.2
Pavlov. Cond. change in total contacts0.60.73.8-0.0-0.1-0.10.00.20.10.10.6-0.5-0.9-1.3-1.1-1.12.0-0.8
Pavlov. Cond. index score0.91.14.81.11.11.11.11.21.11.11.60.50.1-0.2-0.1-0.12.20.1
Pavlov. Cond. latency score0.60.73.50.90.90.90.70.91.01.01.10.4-0.0-0.3-0.1-0.21.90.0
Pavlov. Cond. lever contacts0.70.95.11.00.80.80.80.91.01.01.30.4-0.2-0.4-0.3-0.12.30.3
Pavlov. Cond. magazine entry number1.62.05.8-1.7-1.5-1.5-1.8-1.7-1.4-1.4-2.1-0.9-0.6-0.4-0.2-0.6-2.4-0.7
Pavlov. Cond. intertrial magazine entries0.30.31.5-0.0-0.1-0.1-0.3-0.0-0.2-0.20.1-0.0-0.5-0.9-0.4-1.01.2-1.0
Pavlov. Cond. lever-magazine prob. diff.1.41.76.21.51.51.51.41.51.51.51.80.90.40.10.20.32.50.5
Pavlov. Cond. response bias1.21.56.81.31.11.11.61.51.11.12.10.30.1-0.1-0.40.02.60.3
Pavlov. Cond. lever latency0.20.30.70.60.60.60.10.20.50.50.00.80.40.70.70.5-0.30.7
Pavlov. Cond. magazine entry latency0.00.10.3-0.10.20.2-0.10.10.40.4-0.1-0.00.1-0.10.1-0.20.1-0.5
Pavlov. Cond. change in total contacts0.20.30.9-0.4-0.3-0.30.50.3-0.4-0.40.7-0.9-0.3-0.7-0.8-0.60.7-0.9
Pavlov. Cond. index score0.10.20.5-0.4-0.3-0.30.10.1-0.3-0.30.3-0.7-0.3-0.6-0.7-0.50.5-0.7
Pavlov. Cond. latency score0.20.20.5-0.4-0.4-0.40.10.0-0.3-0.30.3-0.7-0.4-0.7-0.7-0.60.6-0.7
Pavlov. Cond. lever contacts0.20.30.8-0.7-0.6-0.6-0.2-0.3-0.6-0.6-0.2-0.9-0.4-0.6-0.6-0.5-0.1-0.8
Pavlov. Cond. magazine entry number0.00.00.30.00.00.00.10.00.00.0-0.10.20.20.30.20.3-0.50.3
Pavlov. Cond. intertrial magazine entries1.82.73.7-1.9-1.9-1.9-1.8-1.7-1.7-1.7-1.7-1.5-1.5-1.6-1.3-1.6-1.3-1.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.3-0.1-0.10.30.2-0.2-0.20.4-0.6-0.2-0.5-0.5-0.40.5-0.6
Pavlov. Cond. response bias0.00.10.2-0.3-0.2-0.2-0.1-0.1-0.2-0.2-0.0-0.4-0.2-0.3-0.3-0.20.2-0.4
Time in closed arm before self-admin0.91.22.4-0.9-0.9-0.9-0.1-0.1-0.9-0.90.4-1.4-1.0-1.6-1.5-1.40.8-1.5
Time in closed arm after self-admin0.40.41.6-0.4-0.2-0.20.40.4-0.2-0.20.6-0.9-0.3-1.0-0.8-0.90.8-1.3
Time in open arm before self-admin0.80.81.40.81.11.11.11.11.01.00.80.71.21.20.80.9-0.10.4
Time in open arm after self-admin0.30.41.40.40.40.4-0.2-0.20.20.2-0.50.70.30.90.80.8-0.71.2
Bone: periosteal estimation0.51.03.9-1.0-0.7-0.7-1.9-1.4-0.5-0.5-2.0-0.4-0.7-0.60.0-0.7-1.2-0.5
Bone: periosteal perimeter0.40.72.1-0.9-0.4-0.4-1.5-0.8-0.3-0.3-1.2-0.4-0.6-1.1-0.1-1.3-0.2-1.3
Bone: post-yield work0.50.71.5-0.6-1.0-1.0-1.1-1.1-0.9-0.9-1.2-0.4-0.8-0.3-0.4-0.1-1.00.3
Progressive ratio test 1 active lever presses1.11.32.11.31.31.30.70.71.31.30.61.41.11.31.21.30.71.4
Progressive ratio test 1 breakpoint1.21.52.31.41.41.40.80.71.41.40.71.51.11.31.31.40.71.5
Progressive ratio test 1 inactive lever presses0.40.61.21.00.80.80.50.50.80.80.80.90.40.50.50.71.11.0
Progressive ratio test 2 active lever presses1.21.42.01.31.31.30.70.81.31.30.51.41.21.41.31.30.51.3
Progressive ratio test 2 breakpoint1.31.52.21.41.31.30.80.91.41.40.61.51.21.41.31.40.51.3
Progressive ratio test 2 inactive lever presses1.62.53.31.81.81.81.41.41.81.81.11.71.71.71.61.70.81.5
Incentive Sensitization - Responses0.10.20.30.50.50.50.20.30.50.50.00.60.50.50.60.6-0.00.5
Incentive Sensitization - Breakpoint0.10.10.20.40.40.40.10.20.40.4-0.10.50.40.40.50.5-0.10.4
Sum of active levers in priming session hrs 5-60.30.21.7-0.4-0.2-0.2-0.4-0.5-0.2-0.2-0.7-0.10.20.50.30.3-1.30.2
Progressive ratio0.50.82.3-1.0-0.9-0.9-1.3-1.2-0.9-0.9-1.5-0.4-0.5-0.3-0.0-0.3-1.5-0.2
Food seeking constrained by brief footshock1.72.12.9-1.4-1.7-1.7-1.5-1.3-1.7-1.7-1.1-1.2-1.6-1.7-1.3-1.7-0.1-1.3
Seeking ratio, punishment vs. effort0.20.40.8-0.2-0.6-0.6-0.4-0.2-0.5-0.50.1-0.3-0.9-0.9-0.8-0.80.9-0.4
Retroperitoneal fat weight0.20.83.9-0.1-0.2-0.2-1.9-1.1-0.1-0.1-2.00.8-0.1-0.00.9-0.2-1.0-0.3
Reaction time number correct0.71.32.91.11.21.21.61.71.41.41.70.50.90.40.30.21.4-0.3
Reaction time mean minus median0.51.32.21.41.21.20.90.71.11.10.91.50.81.41.11.20.41.5
Reaction time mean minus median AUC1.12.74.32.01.91.91.31.31.81.81.22.11.41.71.61.50.91.7
Reaction time num false alarms1.82.65.21.51.91.91.11.72.12.10.61.72.31.42.11.30.10.5
Reaction time num false alarms AUC1.42.24.51.41.81.81.42.01.91.91.01.32.11.11.60.90.50.1
Reaction time trials correct on left0.71.32.91.11.21.21.61.71.41.41.70.50.90.40.30.21.4-0.3
Reaction time trials on left0.81.53.11.21.31.31.61.81.51.51.70.71.10.60.50.41.4-0.2
Reaction time mean3.75.98.22.82.92.92.02.02.62.61.62.92.42.72.52.50.82.4
Reaction time mean AUC3.45.57.72.72.82.82.01.92.52.51.62.72.32.62.42.40.82.3
Median of all reaction times4.26.08.42.82.92.92.12.12.62.61.72.82.52.62.52.40.92.2
Reaction time omissions2.33.35.81.92.02.00.81.12.02.00.32.42.02.32.42.0-0.41.9
Reaction time false alarm rate0.40.61.50.70.90.90.50.91.01.00.20.81.20.61.00.6-0.00.1
Reaction time premature initiation rate5.78.010.9-3.3-2.9-2.9-2.6-2.8-3.1-3.1-2.1-3.0-3.1-2.9-2.8-3.0-1.4-2.6
Reaction time premature initiations2.44.26.1-2.4-2.0-2.0-1.6-1.7-2.1-2.1-1.2-2.4-2.2-2.3-2.2-2.5-0.8-2.4
Std. dev. reaction times1.22.33.51.81.81.81.11.01.51.50.91.91.31.81.51.60.41.8
Reaction time trials completed0.81.53.11.21.31.31.61.81.51.51.70.71.10.60.50.41.4-0.2
Reaction time trials AUC0.81.63.21.31.41.41.61.81.61.61.60.81.20.70.60.51.3-0.0
Run reversals in cocaine runway, females1.81.85.21.10.90.9-0.6-0.71.01.0-1.01.90.71.71.91.8-1.12.3
Run reversals in cocaine runway, males1.01.01.71.01.31.31.21.11.11.10.90.81.21.00.91.00.30.7
Latency to leave start box in cocaine runway1.01.12.70.80.70.7-0.4-0.30.70.7-0.91.50.91.31.61.5-1.11.6
Latency to leave start box in cocaine runway, F1.11.23.61.20.90.90.30.30.90.90.01.50.91.51.41.6-0.11.9
Latency to leave start box in cocaine runway, M0.60.62.9-0.6-0.3-0.3-1.3-1.0-0.2-0.2-1.60.1-0.1-0.20.40.1-1.70.0
Std. dev. time between licks in bursts0.91.22.6-1.6-1.0-1.0-1.0-0.9-0.9-0.9-1.1-1.3-0.6-1.0-0.7-1.2-1.2-1.6
Total sessions with >9 infusions1.92.45.51.81.51.51.91.91.61.62.21.21.20.90.60.82.40.6
Short access day 1 total inactive lever presses0.30.32.00.70.20.2-0.3-0.70.20.2-0.01.0-0.20.30.50.70.41.4
Short access day 10 total inactive lever presses0.82.03.4-1.4-1.5-1.5-0.8-0.8-1.5-1.5-0.3-1.7-1.7-1.8-1.8-1.80.4-1.6
Short access day 1 total infusions2.33.17.92.11.71.72.21.91.61.62.71.61.10.90.61.02.81.0
Short access day 10 total infusions0.70.91.51.11.11.10.81.01.11.10.91.00.80.80.70.71.20.7
Short access total infusions1.11.52.21.51.31.31.21.21.31.31.31.31.01.00.81.01.51.0
Short access day 1 locomotion2.93.65.92.32.02.02.22.01.91.92.41.81.61.41.11.42.41.3
Short access day 10 total locomotion0.71.33.01.11.21.21.71.71.31.31.50.51.50.80.60.70.60.1
Short access total locomotion2.32.85.01.91.81.82.22.11.71.72.21.31.71.31.01.21.50.8
One hour access (0.3 mA shock)0.80.91.21.01.01.00.70.81.11.10.41.01.11.01.11.10.31.0
Compulsive drug intake0.60.71.7-0.2-0.1-0.10.90.9-0.1-0.11.2-0.9-0.3-0.9-1.0-1.01.3-1.3
One hour access (shock baseline)0.71.12.30.90.90.90.20.31.01.0-0.31.41.11.51.51.5-0.61.5
Social response proportion0.70.82.00.70.80.8-0.00.20.60.6-0.41.21.01.41.41.0-0.91.0
Social responses0.30.43.1-0.50.00.0-0.20.1-0.0-0.0-0.7-0.10.90.60.80.2-1.8-0.4
Social time0.40.62.0-0.8-0.6-0.60.20.1-0.7-0.70.3-1.1-0.4-1.0-1.0-1.0-0.1-1.4
Soleus weight0.10.21.1-0.10.20.2-0.1-0.00.30.3-0.40.30.70.60.60.5-1.00.1
Bone: stiffness0.50.82.8-0.1-0.2-0.2-1.6-1.6-0.2-0.2-1.70.5-0.60.20.50.5-0.91.3
Tibialis anterior weight0.20.71.10.91.01.00.71.01.01.00.70.90.90.60.80.30.80.0
Time to tail flick, vehicle, before self-admin0.40.40.7-0.8-0.8-0.8-0.6-0.7-0.8-0.8-0.6-0.7-0.6-0.6-0.6-0.4-0.6-0.3
Time to tail flick, vehicle, after self-admin0.70.93.3-1.2-0.8-0.8-1.2-1.3-0.9-0.9-1.5-0.7-0.4-0.2-0.1-0.2-1.80.1
Time to tail flick, test, before self-admin2.93.15.82.31.81.81.11.11.71.70.82.41.61.92.02.10.72.1
Time to tail flick, test, after self-admin0.00.00.1-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.3-0.00.10.00.10.1-0.30.1
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.2-0.1-0.1-0.4-0.4-0.2-0.2-0.50.0-0.10.10.20.0-0.30.2
Delta time to tail flick, test, before/after SA0.30.31.0-0.6-0.4-0.40.20.1-0.3-0.30.2-0.9-0.1-0.5-0.6-0.70.0-1.0
Tibia length0.10.41.7-0.0-0.4-0.4-0.4-0.8-0.5-0.50.1-0.2-1.3-0.5-0.8-0.41.20.6
Ambulatory time before self-admin1.32.02.91.71.61.61.31.31.51.51.21.61.21.41.21.41.01.3
Ambulatory time after self-admin0.20.20.40.60.40.40.50.60.50.50.50.50.50.50.40.60.30.5
Bone: tissue strength1.11.12.71.41.31.30.91.01.11.11.01.20.70.60.80.51.60.6
Total heroin consumption0.20.21.0-0.00.30.3-0.1-0.00.30.3-0.40.30.60.80.60.5-1.00.3
Bone: trabecular number4.67.615.0-3.0-3.0-3.0-1.1-1.5-3.0-3.0-0.4-3.8-3.2-3.1-3.9-3.00.1-2.5
Bone: trabecular spacing3.64.88.52.42.42.41.21.42.52.50.62.92.62.52.92.40.01.9
Bone: trabecular thickness0.81.01.8-1.0-1.3-1.3-0.9-0.9-1.0-1.0-0.7-1.1-1.3-0.9-1.2-0.8-0.4-0.3
Bone: trabecular tissue density2.23.36.91.91.91.90.80.51.51.50.22.31.72.42.32.5-0.42.6
Water consumed over 24 hours0.70.91.7-1.3-1.2-1.2-0.8-0.9-0.9-0.9-1.0-1.2-0.6-0.6-0.8-0.5-1.3-0.6
Number of responses in last shaping day1.11.25.30.90.80.81.71.50.70.72.20.10.4-0.2-0.4-0.22.3-0.4