Hub : Genes

Gabrr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio NM_017292.2 0.33 0.17 4.5e-03 0.14 0.16 0.17 0.19 3.2e-03 1.8e-03 1.4e-03 8.2e-04
2 Eye isoform ratio XM_039109383.1 0.25 0.14 6.0e-03 0.15 0.15 0.16 0.14 2.6e-03 3.0e-03 1.7e-03 3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.10.10.4-0.3
Area under the delay curve0.60.70.7-0.80.8
BMI with tail4.314.715.84.0-3.7
BMI without tail4.513.815.23.9-3.5
Body weight6.126.628.75.4-4.9
Weight adjusted by age0.10.10.2-0.40.2
Bone surface0.30.60.60.7-0.8
Bone volume0.10.10.20.4-0.4
Breakpoint value in progressive ratio session0.91.11.21.0-1.1
Number of licking bursts0.40.60.9-0.90.6
Context. condit. distance diff. score0.81.01.1-1.11.0
Locomotion velocity, session 10.00.00.10.0-0.2
Locomotion distance, session 11.41.71.9-1.21.4
Locomotion velocity, session 20.00.00.00.1-0.1
Locomotion distance, session 22.33.23.5-1.71.9
Locomotion velocity, session 31.41.51.8-1.31.1
Locomotion distance, session 32.83.13.6-1.91.6
Stereotopy head waving bouts, day 30.40.50.80.9-0.4
Stereotopy head waving duration, day 31.11.31.61.3-1.0
Locomotion velocity, session 70.00.10.1-0.20.3
Locomotion distance, session 70.60.80.9-1.00.8
Stereotopy head waving bouts, day 70.30.30.40.6-0.5
Stereotopy head waving duration, day 71.41.61.91.4-1.2
Locomotion velocity, session 81.51.81.9-1.41.3
Locomotion distance, session 84.97.27.2-2.72.7
Degree of sensitization distance1.31.31.41.2-1.1
Degree of sensitization stereotypy0.20.20.30.5-0.5
Conditioned locomotion0.10.10.20.4-0.1
Cocaine response after cond. corrected0.10.10.10.3-0.4
Cocaine response after cond. not corrected0.00.10.1-0.30.2
Cocaine response before conditioning0.50.50.6-0.70.8
Saline control response0.20.20.40.3-0.6
Bone: connectivity density0.20.30.50.7-0.4
Bone: cortical apparent density0.20.20.3-0.30.6
Bone: cortical area2.23.43.51.9-1.8
Bone: cortical porosity0.20.30.3-0.40.6
Bone: cortical porosity0.10.10.10.3-0.2
Bone: cortical thickness0.30.50.50.7-0.7
Bone: cortical thickness0.20.30.4-0.30.6
Bone: cortical tissue density0.20.30.4-0.40.6
Condit. Reinf. active minus inactive responses1.61.82.4-1.51.1
Condit. Reinf. active-inactive response ratio1.92.02.6-1.61.2
Condit. Reinf. active responses0.50.71.0-1.00.6
Condit. Reinf. inactive responses0.10.10.10.2-0.3
Incentive salience index mean0.30.30.6-0.80.3
Condit. Reinf. lever presses0.30.50.60.6-0.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.30.4
Condit. Reinf. active-inactive response ratio0.20.20.3-0.30.5
Condit. Reinf. active responses0.00.00.0-0.10.2
Condit. Reinf. inactive responses0.00.00.00.2-0.0
Condit. Reinf. lever presses0.10.10.20.4-0.1
Condit. Reinf. lever reinforcers received0.00.00.00.1-0.0
Conditioned reinforcement - actives0.30.60.70.6-0.9
Conditioned reinforcement - inactives0.50.81.41.2-0.3
Conditioned locomotion1.72.23.01.2-1.7
Patch foraging indifference point 0 sec0.20.40.50.6-0.7
Patch foraging indifference point AUC0.60.90.90.9-0.9
Delay disc. indifference point, 0s delay1.71.91.9-1.41.4
Delay disc. indifference point, 16s delay0.10.10.2-0.10.4
Delay disc. indifference point, 2s delay1.92.12.4-1.31.5
Delay disc. indifference point, 24s delay0.20.20.3-0.50.2
Delay disc. indifference point, 4s delay0.20.20.2-0.40.5
Delay disc. indifference point, 8s delay1.01.21.3-1.01.1
Indifference point function ln k0.00.00.0-0.0-0.1
Indifference point function log k0.00.00.0-0.0-0.1
Patch foraging total patch changes 0 sec0.10.10.20.3-0.4
Patch foraging total patch changes 12 sec1.01.31.61.3-1.0
Patch foraging total patch changes 18 sec0.20.30.4-0.60.5
Patch foraging total patch changes 24 sec0.30.50.60.8-0.6
Patch foraging total patch changes 6 sec0.60.91.00.9-1.0
Patch foraging time to switch 0 sec0.51.11.1-1.01.1
Patch foraging water rate 0 sec0.91.82.11.3-1.4
Patch foraging water rate 12 sec0.00.10.1-0.30.3
Patch foraging water rate 18 sec0.00.00.0-0.20.1
Patch foraging water rate 24 sec0.10.10.10.3-0.3
Patch foraging water rate 6 sec0.30.40.60.5-0.7
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.2-0.2
Distance traveled before self-admin0.40.50.6-0.70.7
Distance traveled after self-admin0.10.10.30.10.5
Extensor digitorum longus weight3.915.218.34.3-3.5
Bone: elastic displacement0.20.20.20.5-0.5
Bone: elastic work3.74.95.72.4-2.0
Bone: endosteal estimation2.55.45.92.4-2.2
Bone: endosteal perimeter2.86.16.62.4-2.6
Epididymis fat weight0.00.00.0-0.00.2
Delta time in closed arm before/after self-admin2.01.92.1-1.41.3
Delta time in open arm before/after self-admin0.10.10.20.40.0
Diff in mean of infusions in LGA sessions0.10.10.1-0.30.2
Delay discount exponential model param0.40.50.50.7-0.7
Extinction: sum of active levers before priming0.00.00.1-0.30.1
Active lever presses in extinction session 60.80.71.2-0.61.1
Bone: final force1.52.42.51.5-1.6
Bone: final moment2.23.63.82.0-1.8
Food consumed during 24 hour testing period1.11.61.61.2-1.3
Glucose0.30.40.50.6-0.7
Heart weight0.40.60.80.9-0.6
Delay discount hyperbolic model param0.50.60.60.7-0.8
Intermittent access intake day 1-15 change1.83.83.9-1.92.0
Intermittent access intake escalation1.53.03.4-1.61.9
Intermittent access intake escalation 23.13.54.2-1.72.0
Intermitt. access day 1 inactive lever presses0.20.60.9-0.51.0
Intermitt. access day 15 inactive lever presses0.00.10.20.10.4
Intermitt. access escalation Index0.10.10.20.4-0.3
Intermittent access day 1 total infusions2.03.23.31.8-1.8
Intermittent access day 15 total infusions0.10.20.30.6-0.2
Intermittent access terminal intake (last 3 days)0.00.00.00.10.1
Intermittent access total infusions2.53.03.21.8-1.7
Intermittent access day 1 locomotion2.32.93.61.5-1.9
Intermittent access day 15 total locomotion0.51.01.10.9-1.1
Intermittent access total locomotion1.11.31.61.0-1.3
Intermittent access standard deviation0.30.70.9-0.90.7
Left kidney weight0.62.63.01.7-1.5
Right kidney weight0.62.83.41.9-1.4
Cocaine induced anxiety0.20.30.5-0.70.4
Post-drug Anxiety0.10.10.10.2-0.3
Baseline Anxiety0.80.91.21.1-0.8
Tail length1.24.85.72.4-2.0
Length with tail1.77.48.72.9-2.5
Length without tail0.72.42.91.7-1.4
Times rat made contact with spout0.20.30.3-0.50.5
Lifetime Intake2.63.23.61.9-1.7
Liver weight, left0.50.81.01.0-0.8
Liver weight, right0.61.11.71.3-0.7
Locomotor activity0.10.20.2-0.50.4
Locomotor testing distance0.20.40.4-0.50.7
Locomotor testing rearing1.32.72.9-1.61.7
Locomotion in novel chamber0.10.20.40.6-0.1
Locomotion in novel chamber post-restriction0.10.10.20.4-0.2
Fecal boli incidents, locomotor time 10.00.00.0-0.20.2
Change in fecal boli incidents, locomotor task0.00.00.0-0.20.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.30.4
Bouts of movement, locomotor time 10.00.00.0-0.20.2
Total resting periods, locomotor time 10.10.10.1-0.20.3
Rest time, locomotor task time 10.00.00.00.10.1
Distance moved, locomotor task time 10.00.00.0-0.20.0
Vertical activity count, locomotor time 10.20.50.5-0.60.7
Time >=10cm from walls, locomotor time 20.00.10.10.3-0.2
Bouts of movement, locomotor time 21.21.91.91.4-1.4
Total resting periods, locomotor time 21.01.71.71.3-1.3
Rest time, locomotor task time 20.81.01.40.8-1.2
Distance moved, locomotor task time 20.20.20.2-0.40.5
Vertical activity count, locomotor time 20.00.00.00.10.2
Light reinforcement 11.02.63.21.8-1.4
Light reinforcement 21.01.61.61.2-1.3
Bone: marrow area2.45.25.72.4-2.2
Bone: maximum diameter2.75.15.32.2-2.3
Bone: maximum force2.64.64.62.1-2.2
Bone: maximum moment3.15.45.82.4-2.2
Mean time between licks in bursts0.20.60.70.9-0.6
Mean num. licks in bursts0.10.20.40.6-0.1
Cd content in liver1.82.12.21.4-1.5
Co content in liver0.20.20.3-0.30.5
Cu content in liver0.00.00.0-0.10.1
Fe content in liver0.10.10.20.10.4
K content in liver0.60.60.7-0.80.7
Mg content in liver0.00.00.1-0.3-0.1
Mn content in liver0.10.20.30.5-0.3
Na content in liver2.22.32.4-1.51.5
Rb content in liver1.82.12.4-1.31.6
Se content in liver4.85.76.2-2.32.5
Sr content in liver1.61.31.4-1.21.1
Zn content in liver0.10.10.20.1-0.5
Bone: minimum diameter1.52.72.81.7-1.6
Time in familiar zone, hab. session 12.12.12.11.4-1.4
Time in novel zone, hab. session 16.96.97.6-2.82.5
Total zone transitions, hab. session 13.95.45.6-2.42.3
Total locomotion distance, hab. session 14.56.47.3-2.42.7
Locomotion velocity, hab. session 12.73.84.5-1.82.1
Time in familiar zone, hab. session 20.80.81.11.1-0.7
Time in novel zone, hab. session 20.50.50.7-0.80.6
Total zone transitions, hab. session 21.21.51.6-1.21.3
Total locomotion distance, hab. session 20.81.01.4-0.71.2
Locomotion velocity, hab. session 20.70.91.2-0.71.1
Novel to familiar place preference ratio0.00.00.0-0.20.1
Novelty place preference0.40.40.5-0.70.6
Time in novel zone, NPP test0.70.80.9-0.90.8
Total zone transitions, NPP test1.92.72.9-1.61.7
Total locomotion distance, NPP test0.50.71.1-0.61.0
Locomotion velocity, NPP test0.20.20.4-0.20.6
Intraocular pressure5.17.48.22.5-2.9
Delta distance traveled before/after self-admin0.40.40.80.9-0.3
Delta ambulatory time before/after self-admin0.30.40.80.9-0.3
Parametrial fat weight0.00.10.1-0.30.3
Pavlov. Cond. lever latency2.83.64.2-1.72.0
Pavlov. Cond. magazine entry latency1.41.71.91.3-1.4
Pavlov. Cond. change in total contacts0.00.00.0-0.1-0.2
Pavlov. Cond. index score2.12.63.11.5-1.8
Pavlov. Cond. latency score2.73.44.01.7-2.0
Pavlov. Cond. lever contacts2.83.43.81.7-2.0
Pavlov. Cond. magazine entry number1.62.02.2-1.41.5
Pavlov. Cond. intertrial magazine entries4.04.85.3-2.12.3
Pavlov. Cond. lever-magazine prob. diff.1.51.92.31.2-1.5
Pavlov. Cond. response bias1.72.12.31.4-1.5
Pavlov. Cond. lever latency0.20.20.40.2-0.6
Pavlov. Cond. magazine entry latency0.91.11.4-0.91.2
Pavlov. Cond. change in total contacts0.20.30.5-0.40.7
Pavlov. Cond. index score0.50.71.0-0.61.0
Pavlov. Cond. latency score0.10.10.2-0.20.4
Pavlov. Cond. lever contacts0.20.30.5-0.30.7
Pavlov. Cond. magazine entry number0.81.01.40.7-1.2
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.71.0-0.61.0
Pavlov. Cond. response bias0.91.32.0-0.71.4
Time in closed arm before self-admin1.31.71.91.4-1.2
Time in closed arm after self-admin0.10.10.2-0.40.1
Time in open arm before self-admin0.50.60.9-1.00.4
Time in open arm after self-admin0.10.10.10.4-0.4
Bone: periosteal estimation3.16.67.12.7-2.5
Bone: periosteal perimeter5.39.19.52.9-3.1
Bone: post-yield work0.20.30.50.7-0.4
Progressive ratio test 1 active lever presses2.63.33.71.9-1.7
Progressive ratio test 1 breakpoint2.63.23.61.9-1.6
Progressive ratio test 1 inactive lever presses0.00.00.10.00.3
Progressive ratio test 2 active lever presses0.40.50.80.9-0.5
Progressive ratio test 2 breakpoint0.50.61.01.0-0.5
Progressive ratio test 2 inactive lever presses0.40.60.91.0-0.5
Incentive Sensitization - Responses0.10.10.20.40.3
Incentive Sensitization - Breakpoint0.10.10.20.40.3
Sum of active levers in priming session hrs 5-60.30.30.40.7-0.3
Progressive ratio0.91.42.01.4-0.8
Food seeking constrained by brief footshock0.80.91.11.0-0.9
Seeking ratio, punishment vs. effort0.71.11.4-1.20.8
Retroperitoneal fat weight0.83.53.7-1.91.8
Reaction time number correct0.30.60.90.5-1.0
Reaction time mean minus median0.00.10.1-0.10.3
Reaction time mean minus median AUC0.10.30.4-0.40.6
Reaction time num false alarms1.01.31.31.2-1.2
Reaction time num false alarms AUC0.91.51.61.2-1.2
Reaction time trials correct on left0.30.60.90.5-1.0
Reaction time trials on left0.40.71.00.6-1.0
Reaction time mean1.01.61.71.3-1.2
Reaction time mean AUC0.60.91.01.0-0.9
Median of all reaction times1.92.62.71.6-1.6
Reaction time omissions0.71.01.21.1-0.9
Reaction time false alarm rate0.30.40.50.7-0.6
Reaction time premature initiation rate0.40.60.60.8-0.8
Reaction time premature initiations0.91.71.81.2-1.4
Std. dev. reaction times0.00.00.0-0.10.2
Reaction time trials completed0.40.71.00.6-1.0
Reaction time trials AUC0.30.60.90.5-1.0
Run reversals in cocaine runway, females0.40.40.50.5-0.7
Run reversals in cocaine runway, males0.10.10.1-0.10.3
Latency to leave start box in cocaine runway0.00.00.00.20.0
Latency to leave start box in cocaine runway, F0.10.10.20.3-0.4
Latency to leave start box in cocaine runway, M0.80.81.1-0.71.0
Std. dev. time between licks in bursts0.10.10.20.4-0.3
Total sessions with >9 infusions2.83.44.12.0-1.6
Short access day 1 total inactive lever presses1.01.41.51.2-1.1
Short access day 10 total inactive lever presses1.33.23.7-1.91.7
Short access day 1 total infusions0.50.60.80.9-0.6
Short access day 10 total infusions1.21.61.61.3-1.2
Short access total infusions2.63.33.92.0-1.6
Short access day 1 locomotion0.20.30.30.6-0.4
Short access day 10 total locomotion1.32.53.11.4-1.8
Short access total locomotion3.23.94.12.0-1.9
One hour access (0.3 mA shock)0.10.10.20.10.4
Compulsive drug intake0.50.60.8-0.60.9
One hour access (shock baseline)0.50.81.01.0-0.8
Social response proportion1.51.72.1-1.41.2
Social responses1.72.22.7-1.31.6
Social time1.52.12.1-1.41.5
Soleus weight0.92.83.61.9-1.4
Bone: stiffness0.00.00.10.0-0.2
Tibialis anterior weight5.017.120.94.6-3.6
Time to tail flick, vehicle, before self-admin0.20.20.2-0.40.5
Time to tail flick, vehicle, after self-admin0.00.10.1-0.30.2
Time to tail flick, test, before self-admin3.33.43.71.8-1.9
Time to tail flick, test, after self-admin0.90.91.01.0-1.0
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.30.3
Delta time to tail flick, test, before/after SA0.30.30.3-0.50.6
Tibia length1.13.13.51.9-1.7
Ambulatory time before self-admin0.60.90.9-0.91.0
Ambulatory time after self-admin0.30.30.70.8-0.1
Bone: tissue strength0.50.50.6-0.60.7
Total heroin consumption1.01.11.81.4-0.7
Bone: trabecular number0.10.20.3-0.30.5
Bone: trabecular spacing1.01.41.51.1-1.2
Bone: trabecular thickness0.00.00.0-0.10.1
Bone: trabecular tissue density4.97.37.5-2.72.7
Water consumed over 24 hours0.20.30.30.6-0.4
Number of responses in last shaping day1.41.61.81.1-1.4