Hub : Genes

G2e3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL intron excision ratio chr6_74517680_74519373 0.16 0.11 5.8e-03 0.01 0.06 0.03 0.05 2.0e-01 1.3e-02 7.6e-02 3.0e-02
2 LHb mRNA stability G2e3 0.19 0.12 1.3e-03 0.05 0.11 0.1 0.08 2.3e-02 1.2e-03 2.6e-03 5.5e-03
3 LHb isoform ratio XM_017594082.3 0.11 0.08 9.7e-03 0.08 0.03 0.02 0.04 6.2e-03 8.4e-02 1.1e-01 4.3e-02
4 Adipose gene expression G2e3 0.09 0.06 6.4e-12 0.1 0.1 0.1 0.1 2.2e-11 1.3e-11 6.1e-11 2.2e-11
5 IC gene expression G2e3 0.21 0.1 9.5e-06 0.11 0.11 0.1 0.1 2.1e-05 2.9e-05 8.7e-05 5.0e-05
6 pVTA gene expression G2e3 0.17 0.09 1.1e-08 0.1 0.1 0.09 0.1 1.2e-08 1.6e-08 5.5e-08 2.8e-08
7 BLA gene expression G2e3 0.13 0.07 6.5e-05 0.06 0.07 0.07 0.07 3.2e-04 1.2e-04 9.8e-05 2.0e-04
8 LHb gene expression G2e3 0.22 0.14 2.6e-03 0.13 0.1 0.09 0.1 4.7e-04 3.0e-03 4.5e-03 2.7e-03
9 OFC gene expression G2e3 0.56 0.24 1.3e-04 0.14 0.14 0.12 0.13 3.1e-04 4.0e-04 7.2e-04 6.7e-04
10 NAcc gene expression G2e3 0.11 0.05 4.9e-14 0.1 0.1 0.11 0.11 2.6e-15 1.7e-15 1.0e-15 4.5e-16
11 PL gene expression G2e3 0.17 0.09 1.8e-14 0.13 0.14 0.13 0.14 3.9e-14 1.0e-14 1.8e-14 8.6e-15
12 NAcc mRNA stability G2e3 0.02 0.01 7.6e-03 0 0 0 0 1.5e-01 6.1e-02 3.0e-01 2.7e-01
13 Brain gene expression G2e3 0.27 0.14 8.1e-14 0.15 0.15 0.16 0.16 1.1e-13 1.1e-13 2.6e-14 7.0e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.62.75.42.32.32.32.31.61.60.91.6-0.41.2-0.21.90.2
Area under the delay curve1.72.04.20.70.7-0.2-0.21.71.71.81.61.21.91.8-1.22.0
BMI with tail0.72.36.00.80.91.71.8-0.3-0.3-1.4-0.3-2.4-0.8-2.42.2-1.8
BMI without tail1.23.710.31.51.52.52.7-0.1-0.1-1.3-0.2-2.8-0.8-2.43.2-2.0
Body weight1.66.814.73.53.53.83.82.42.41.02.5-2.01.8-0.63.00.1
Weight adjusted by age0.81.12.2-1.2-1.0-0.9-0.6-1.2-1.2-1.5-1.0-1.5-1.1-1.0-0.3-1.0
Bone surface2.13.96.12.12.01.41.22.42.42.52.41.82.41.90.11.8
Bone volume2.03.75.82.42.41.91.92.32.32.02.30.82.11.10.91.3
Breakpoint value in progressive ratio session2.22.65.12.22.31.92.11.81.81.21.9-0.61.50.41.30.7
Number of licking bursts0.10.10.2-0.4-0.4-0.3-0.3-0.4-0.4-0.4-0.40.0-0.3-0.1-0.2-0.2
Context. condit. distance diff. score0.91.04.1-0.00.20.20.7-0.6-0.6-1.3-0.6-2.0-1.0-1.61.1-1.1
Locomotion velocity, session 10.10.10.20.30.4-0.00.20.50.50.50.40.10.30.1-0.00.3
Locomotion distance, session 11.21.62.7-1.7-1.6-1.6-1.5-1.4-1.4-0.9-1.50.4-1.2-0.3-0.9-0.8
Locomotion velocity, session 21.21.54.0-1.5-1.5-1.8-1.9-0.5-0.50.3-0.51.2-0.20.9-2.00.6
Locomotion distance, session 21.82.55.6-2.2-2.3-2.2-2.4-1.4-1.4-0.6-1.50.9-1.10.2-1.9-0.3
Locomotion velocity, session 31.41.64.0-1.6-1.6-1.9-2.0-0.8-0.80.2-1.01.3-0.41.1-1.70.2
Locomotion distance, session 30.91.02.0-1.2-1.3-0.7-1.0-1.3-1.3-0.8-1.40.2-1.1-0.1-0.2-1.1
Stereotopy head waving bouts, day 31.11.23.9-1.3-1.2-2.0-1.7-0.4-0.40.2-0.51.2-0.10.7-1.80.6
Stereotopy head waving duration, day 30.81.02.9-1.0-0.9-1.7-1.5-0.2-0.20.5-0.31.20.20.8-1.70.9
Locomotion velocity, session 74.14.47.3-1.7-1.7-0.6-0.6-2.6-2.6-2.7-2.7-2.0-2.6-2.20.9-2.6
Locomotion distance, session 72.83.66.3-1.0-1.10.20.1-2.2-2.2-2.5-2.2-1.9-2.4-2.41.5-2.5
Stereotopy head waving bouts, day 70.40.51.10.20.2-0.4-0.30.70.71.00.60.90.81.1-0.70.8
Stereotopy head waving duration, day 70.81.02.2-0.3-0.3-1.1-1.00.50.51.20.41.50.81.5-1.51.1
Locomotion velocity, session 80.10.10.3-0.00.1-0.5-0.20.30.30.60.20.20.30.6-0.50.5
Locomotion distance, session 80.40.60.9-0.9-0.9-0.9-0.7-0.9-0.9-0.8-0.9-0.6-0.9-0.6-0.3-0.6
Degree of sensitization distance0.30.31.00.40.40.60.7-0.0-0.0-0.40.1-1.0-0.2-1.00.7-0.2
Degree of sensitization stereotypy0.91.01.51.01.10.60.61.21.21.21.20.71.21.10.00.8
Conditioned locomotion1.11.23.0-1.2-1.1-1.7-1.6-0.5-0.50.4-0.41.5-0.11.0-1.60.8
Cocaine response after cond. corrected0.40.40.7-0.5-0.5-0.1-0.1-0.8-0.8-0.7-0.7-0.8-0.9-0.80.3-0.8
Cocaine response after cond. not corrected0.80.92.1-0.1-0.10.60.6-0.8-0.8-1.1-0.8-1.4-1.1-1.31.2-1.4
Cocaine response before conditioning0.50.61.70.50.41.00.9-0.2-0.2-0.7-0.3-0.9-0.5-0.71.3-1.1
Saline control response0.91.22.61.51.51.51.61.01.00.41.0-1.00.8-0.11.20.1
Bone: connectivity density2.84.49.83.02.93.13.01.91.91.21.9-0.11.40.02.60.0
Bone: cortical apparent density1.52.04.8-0.7-0.60.10.2-1.3-1.3-2.0-1.3-2.2-1.5-2.20.9-1.7
Bone: cortical area2.94.57.31.91.81.30.92.62.62.62.41.92.72.5-0.42.3
Bone: cortical porosity1.71.84.60.40.4-0.3-0.51.21.21.81.12.11.62.0-1.21.8
Bone: cortical porosity1.92.15.80.40.3-0.2-0.61.21.21.91.12.41.62.2-1.31.9
Bone: cortical thickness0.30.51.00.80.71.00.70.80.80.70.70.00.80.50.30.4
Bone: cortical thickness0.20.20.4-0.5-0.5-0.3-0.4-0.6-0.6-0.6-0.5-0.6-0.5-0.6-0.1-0.4
Bone: cortical tissue density1.52.05.0-0.7-0.60.00.2-1.4-1.4-2.0-1.3-2.2-1.5-2.20.9-1.7
Condit. Reinf. active minus inactive responses2.22.43.91.71.51.51.01.91.92.01.91.11.91.50.31.1
Condit. Reinf. active-inactive response ratio0.20.20.30.60.50.60.40.50.50.60.60.30.50.40.30.0
Condit. Reinf. active responses3.24.07.22.01.81.51.02.42.42.72.41.72.42.2-0.11.9
Condit. Reinf. inactive responses1.11.32.80.90.80.50.21.31.31.71.31.21.31.5-0.41.5
Incentive salience index mean3.23.97.51.71.51.30.62.32.32.72.32.12.42.6-0.41.8
Condit. Reinf. lever presses0.91.23.70.50.20.3-0.30.90.91.61.01.71.21.9-0.71.1
Condit. Reinf. active minus inactive responses0.10.20.3-0.5-0.6-0.5-0.6-0.4-0.4-0.0-0.40.5-0.40.2-0.4-0.2
Condit. Reinf. active-inactive response ratio0.20.20.6-0.6-0.6-0.8-0.7-0.4-0.40.1-0.30.5-0.20.3-0.70.1
Condit. Reinf. active responses0.20.30.8-0.6-0.7-0.6-0.7-0.5-0.5-0.0-0.50.9-0.40.3-0.4-0.3
Condit. Reinf. inactive responses0.10.20.60.10.00.30.2-0.4-0.4-0.4-0.40.1-0.5-0.30.6-0.8
Condit. Reinf. lever presses0.91.32.01.41.41.01.01.21.21.31.21.21.11.10.70.7
Condit. Reinf. lever reinforcers received0.40.62.30.40.30.1-0.10.60.61.10.61.50.71.2-0.30.7
Conditioned reinforcement - actives2.03.46.11.91.81.00.92.12.12.52.12.22.01.80.01.9
Conditioned reinforcement - inactives1.92.85.42.32.32.02.01.71.71.61.81.01.30.61.60.5
Conditioned locomotion0.20.21.00.40.30.30.10.40.40.60.31.00.30.50.00.5
Patch foraging indifference point 0 sec2.34.37.81.91.71.30.82.52.52.82.52.12.52.2-0.42.1
Patch foraging indifference point AUC3.34.714.90.90.7-0.1-0.62.02.03.01.93.92.43.0-1.62.6
Delay disc. indifference point, 0s delay0.40.51.00.60.70.10.41.01.00.60.9-0.31.00.6-0.30.8
Delay disc. indifference point, 16s delay1.61.74.20.40.4-0.5-0.41.41.41.61.41.21.71.8-1.42.1
Delay disc. indifference point, 2s delay0.50.61.10.60.60.30.21.01.01.00.80.91.00.9-0.30.9
Delay disc. indifference point, 24s delay3.13.56.41.11.1-0.10.02.22.22.52.31.72.42.3-1.32.4
Delay disc. indifference point, 4s delay0.40.41.1-0.7-0.6-1.0-0.9-0.0-0.00.0-0.20.40.30.6-1.10.7
Delay disc. indifference point, 8s delay0.70.81.60.60.50.20.11.11.11.31.11.01.11.1-0.51.2
Indifference point function ln k0.50.84.2-0.1-0.10.40.5-0.6-0.6-1.1-0.6-2.0-0.8-1.20.8-1.0
Indifference point function log k0.50.84.2-0.1-0.10.40.5-0.6-0.6-1.1-0.6-2.0-0.8-1.20.8-1.0
Patch foraging total patch changes 0 sec2.75.19.32.01.81.30.72.82.83.12.72.42.72.4-0.52.4
Patch foraging total patch changes 12 sec4.45.810.62.01.71.30.62.82.83.32.73.22.92.8-0.62.4
Patch foraging total patch changes 18 sec1.21.94.60.90.70.50.01.51.51.91.42.11.51.8-0.51.4
Patch foraging total patch changes 24 sec1.62.87.91.10.90.60.01.81.82.31.62.81.92.3-0.61.7
Patch foraging total patch changes 6 sec3.24.99.52.11.81.40.82.62.63.02.43.12.52.4-0.12.1
Patch foraging time to switch 0 sec8.717.833.3-2.7-2.5-0.7-0.1-4.8-4.8-5.8-4.8-4.7-5.3-5.32.6-5.5
Patch foraging water rate 0 sec2.75.711.51.31.20.3-0.22.72.73.42.62.62.93.2-1.73.0
Patch foraging water rate 12 sec0.81.73.21.81.71.61.61.51.51.31.60.11.20.41.00.8
Patch foraging water rate 18 sec1.11.73.11.31.30.90.81.71.71.51.80.41.71.3-0.21.5
Patch foraging water rate 24 sec1.01.42.81.00.90.60.41.41.41.71.41.01.41.3-0.31.5
Patch foraging water rate 6 sec4.36.211.21.91.80.80.52.92.93.33.02.13.33.2-1.13.1
Seeking ratio, delayed vs. immediate footshock1.01.23.1-1.5-1.6-1.4-1.8-0.8-0.8-0.0-0.70.8-0.30.9-1.70.3
Distance traveled before self-admin0.20.30.9-0.2-0.3-0.3-0.50.30.30.60.20.60.51.0-0.70.6
Distance traveled after self-admin0.20.21.1-0.2-0.1-0.00.1-0.3-0.3-0.7-0.3-1.0-0.3-0.60.2-0.3
Extensor digitorum longus weight2.59.823.14.24.34.54.82.62.60.62.6-2.21.5-1.34.1-0.2
Bone: elastic displacement0.70.82.20.30.30.90.9-0.5-0.5-0.8-0.6-0.8-0.8-1.21.5-1.3
Bone: elastic work0.81.14.01.00.81.71.4-0.1-0.1-0.5-0.1-0.6-0.5-0.92.0-1.4
Bone: endosteal estimation2.04.38.80.50.5-0.8-0.91.91.92.62.02.92.43.0-2.22.9
Bone: endosteal perimeter3.57.314.21.21.1-0.2-0.62.82.83.52.63.63.33.7-2.33.8
Epididymis fat weight0.61.95.40.20.31.01.2-0.8-0.8-1.6-0.8-2.3-1.3-2.21.7-1.7
Delta time in closed arm before/after self-admin0.30.30.90.80.71.00.70.50.50.40.50.40.50.20.70.0
Delta time in open arm before/after self-admin0.20.20.70.40.50.30.7-0.1-0.1-0.30.0-0.3-0.5-0.80.8-0.4
Diff in mean of infusions in LGA sessions0.30.40.7-0.8-0.8-0.9-0.7-0.6-0.6-0.5-0.5-0.5-0.6-0.3-0.6-0.3
Delay discount exponential model param1.51.73.7-0.4-0.40.40.4-1.4-1.4-1.6-1.3-1.3-1.7-1.71.3-1.9
Extinction: sum of active levers before priming2.52.88.82.32.13.02.41.31.30.91.3-0.41.00.12.2-0.0
Active lever presses in extinction session 63.03.06.42.52.32.52.21.71.71.41.70.41.40.01.80.2
Bone: final force0.00.10.30.10.00.0-0.10.20.20.20.10.40.30.5-0.20.3
Bone: final moment0.10.10.40.20.20.0-0.00.40.40.30.30.50.40.6-0.30.4
Food consumed during 24 hour testing period0.91.21.71.11.00.90.71.31.31.21.30.81.31.30.11.2
Glucose2.13.36.42.52.42.52.31.91.91.31.9-0.11.60.31.70.5
Heart weight1.21.93.11.81.71.41.31.61.61.51.61.11.51.10.70.8
Delay discount hyperbolic model param1.41.63.3-0.4-0.40.40.4-1.4-1.4-1.5-1.2-1.4-1.6-1.71.2-1.8
Intermittent access intake day 1-15 change1.02.15.22.02.02.22.31.11.10.31.1-0.90.6-0.52.10.0
Intermittent access intake escalation0.71.53.61.71.71.81.91.01.00.30.9-0.60.5-0.31.80.1
Intermittent access intake escalation 20.70.82.91.31.11.41.30.40.40.30.30.50.0-0.21.7-0.3
Intermitt. access day 1 inactive lever presses0.31.01.61.11.10.91.11.21.20.71.2-0.91.20.60.31.3
Intermitt. access day 15 inactive lever presses1.83.76.42.02.11.21.42.52.52.02.50.22.51.3-0.12.2
Intermitt. access escalation Index0.00.00.3-0.1-0.00.00.10.00.0-0.3-0.1-0.50.0-0.4-0.0-0.1
Intermittent access day 1 total infusions1.01.64.80.80.50.7-0.01.21.21.81.22.21.31.7-0.41.2
Intermittent access day 15 total infusions1.52.23.81.91.71.91.41.61.61.61.51.41.31.11.11.0
Intermittent access terminal intake (last 3 days)1.92.55.01.81.61.71.11.61.61.91.52.21.41.50.91.1
Intermittent access total infusions1.41.62.41.51.31.51.01.41.41.41.21.51.21.20.70.9
Intermittent access day 1 locomotion2.12.74.91.21.10.80.31.91.92.11.81.81.92.2-0.62.1
Intermittent access day 15 total locomotion0.40.71.71.11.11.31.20.60.60.40.7-0.40.3-0.01.20.0
Intermittent access total locomotion0.81.01.81.31.21.41.11.11.10.91.10.40.90.80.70.8
Intermittent access standard deviation1.12.23.82.01.91.61.61.81.81.31.70.51.40.81.01.2
Left kidney weight0.62.87.62.02.31.92.51.31.30.11.3-2.80.8-1.11.90.1
Right kidney weight0.52.27.71.51.71.62.20.60.6-0.50.6-2.80.2-1.51.9-0.6
Cocaine induced anxiety1.31.85.5-0.4-0.4-1.3-1.30.60.61.60.62.41.11.8-1.81.7
Post-drug Anxiety1.81.95.60.00.0-0.9-1.00.90.91.80.92.41.41.7-1.62.0
Baseline Anxiety0.30.40.80.10.20.60.6-0.3-0.3-0.8-0.3-0.9-0.6-0.90.8-0.8
Tail length1.03.97.52.72.72.72.72.02.01.22.0-0.81.60.42.00.8
Length with tail1.98.313.73.73.73.13.13.43.42.63.40.13.21.61.62.1
Length without tail1.54.88.22.22.31.41.32.82.82.52.81.02.91.8-0.22.3
Times rat made contact with spout0.81.02.4-0.8-0.7-0.3-0.2-1.1-1.1-1.5-1.1-1.3-1.1-1.20.3-1.0
Lifetime Intake1.21.42.31.51.41.51.11.31.31.21.11.21.00.90.90.8
Liver weight, left2.03.37.92.32.32.72.81.31.30.11.3-2.00.9-1.12.4-0.1
Liver weight, right1.93.29.11.11.12.02.3-0.4-0.4-1.6-0.3-3.0-1.0-2.52.8-1.9
Locomotor activity6.410.017.14.14.03.43.23.63.63.03.81.63.31.71.92.2
Locomotor testing distance3.46.112.13.53.33.33.12.52.51.92.60.92.10.82.41.0
Locomotor testing rearing2.44.813.03.22.93.63.21.61.61.01.70.41.0-0.03.3-0.3
Locomotion in novel chamber1.92.54.6-1.6-1.8-0.9-1.3-2.1-2.1-1.4-2.10.5-2.1-0.90.1-1.6
Locomotion in novel chamber post-restriction0.81.33.6-1.4-1.5-1.5-1.9-0.5-0.50.3-0.41.3-0.01.0-1.90.5
Fecal boli incidents, locomotor time 11.42.05.11.81.82.32.20.90.90.21.0-1.20.4-1.02.0-0.6
Change in fecal boli incidents, locomotor task0.00.00.10.10.10.10.2-0.0-0.0-0.2-0.1-0.3-0.1-0.00.3-0.0
Time >=10cm from walls, locomotor time 10.40.40.80.70.70.30.40.80.80.70.90.50.80.70.00.9
Bouts of movement, locomotor time 11.21.43.31.01.20.30.51.51.51.41.80.51.41.2-0.41.3
Total resting periods, locomotor time 11.41.63.51.01.20.10.51.61.61.51.90.71.61.3-0.51.5
Rest time, locomotor task time 11.61.94.10.50.6-0.6-0.31.41.41.61.81.41.71.7-1.42.0
Distance moved, locomotor task time 10.71.02.1-0.2-0.30.40.3-1.0-1.0-1.1-1.1-1.0-1.3-1.41.1-1.4
Vertical activity count, locomotor time 10.51.22.80.20.21.10.9-0.7-0.7-1.2-1.0-1.2-1.1-1.61.7-1.4
Time >=10cm from walls, locomotor time 20.81.12.01.41.21.31.11.11.10.91.00.71.01.10.90.6
Bouts of movement, locomotor time 20.20.30.9-0.1-0.1-0.2-0.40.40.40.60.40.70.61.0-0.80.7
Total resting periods, locomotor time 20.10.10.4-0.2-0.2-0.3-0.40.20.20.20.20.30.40.6-0.70.5
Rest time, locomotor task time 20.10.10.40.10.20.10.30.00.0-0.40.1-0.7-0.0-0.50.10.1
Distance moved, locomotor task time 20.20.31.50.30.2-0.0-0.10.40.40.70.31.20.20.8-0.10.2
Vertical activity count, locomotor time 20.10.10.4-0.3-0.4-0.3-0.4-0.2-0.20.0-0.40.7-0.30.3-0.2-0.3
Light reinforcement 10.20.51.90.90.81.31.10.20.2-0.30.2-0.10.0-0.21.4-0.6
Light reinforcement 20.91.34.1-0.9-0.9-1.2-1.50.20.20.70.31.40.71.7-2.01.3
Bone: marrow area2.14.58.90.60.6-0.8-0.92.02.02.62.12.92.43.0-2.23.0
Bone: maximum diameter5.19.519.11.71.60.3-0.23.43.44.13.23.73.94.4-2.24.0
Bone: maximum force0.50.81.90.40.4-0.0-0.11.01.01.10.91.21.11.4-0.71.2
Bone: maximum moment0.61.02.00.50.4-0.1-0.21.11.11.21.01.41.21.4-0.81.3
Mean time between licks in bursts0.10.20.50.50.70.10.70.30.3-0.00.3-0.5-0.0-0.70.6-0.0
Mean num. licks in bursts0.10.20.80.30.40.50.60.00.0-0.40.0-0.9-0.1-0.60.6-0.4
Cd content in liver0.70.82.11.00.91.51.40.30.3-0.40.4-1.20.0-0.91.4-0.7
Co content in liver0.30.30.90.70.60.90.80.20.20.20.2-0.20.0-0.11.0-0.5
Cu content in liver0.91.11.9-1.2-1.2-0.8-0.8-1.4-1.4-1.1-1.4-0.5-1.3-0.6-0.1-1.0
Fe content in liver1.31.62.9-1.1-1.0-0.7-0.4-1.5-1.5-1.6-1.5-1.2-1.6-1.70.4-1.4
K content in liver6.96.614.1-3.6-3.6-3.6-3.8-2.4-2.4-1.0-2.51.4-1.70.6-3.0-0.3
Mg content in liver6.06.111.7-3.4-3.4-3.3-3.3-2.6-2.6-1.6-2.60.6-2.0-0.1-2.4-0.7
Mn content in liver2.32.67.6-1.7-1.7-2.5-2.5-0.4-0.40.6-0.41.70.21.5-2.81.3
Na content in liver4.54.87.6-2.7-2.7-1.9-2.0-2.7-2.7-2.3-2.8-0.5-2.5-1.5-0.8-1.8
Rb content in liver2.52.94.9-2.2-2.1-2.0-1.9-2.0-2.0-1.5-2.0-0.1-1.8-0.7-1.1-1.1
Se content in liver3.64.38.4-2.8-2.9-2.3-2.6-2.4-2.4-1.6-2.40.3-2.0-0.3-1.5-1.2
Sr content in liver0.40.31.00.70.71.00.90.30.3-0.00.3-0.20.1-0.31.0-0.4
Zn content in liver0.60.61.5-0.9-1.1-0.7-1.2-0.5-0.50.2-0.51.1-0.21.0-1.0-0.0
Bone: minimum diameter2.13.96.61.51.40.80.42.32.32.62.12.42.52.4-0.82.3
Time in familiar zone, hab. session 10.50.41.40.40.40.90.8-0.2-0.2-0.6-0.3-0.7-0.5-0.71.2-0.9
Time in novel zone, hab. session 10.30.31.00.30.4-0.4-0.10.60.60.70.60.30.70.5-0.51.0
Total zone transitions, hab. session 11.72.46.0-1.9-2.0-2.4-2.4-0.8-0.80.3-0.91.5-0.41.2-2.30.5
Total locomotion distance, hab. session 12.13.05.7-2.4-2.3-2.3-2.2-1.9-1.9-1.3-1.90.2-1.7-0.5-1.5-0.7
Locomotion velocity, hab. session 12.33.27.2-2.5-2.5-2.6-2.7-1.5-1.5-0.6-1.51.3-1.20.4-2.2-0.1
Time in familiar zone, hab. session 21.71.84.4-0.2-0.10.60.8-1.1-1.1-1.8-1.1-2.1-1.5-2.01.5-1.6
Time in novel zone, hab. session 22.42.54.60.90.90.0-0.11.71.72.21.71.82.12.1-1.02.0
Total zone transitions, hab. session 22.83.69.6-2.3-2.3-3.0-3.0-0.8-0.80.5-0.81.9-0.21.5-3.10.9
Total locomotion distance, hab. session 22.02.66.5-2.0-2.0-2.5-2.6-0.8-0.80.2-0.81.5-0.31.0-2.60.6
Locomotion velocity, hab. session 22.53.48.6-2.3-2.3-2.8-2.9-0.9-0.90.3-0.91.8-0.31.3-2.90.7
Novel to familiar place preference ratio0.91.02.40.50.40.1-0.21.01.01.41.01.61.21.4-0.71.2
Novelty place preference2.12.24.21.00.80.40.01.61.62.01.61.91.91.9-0.81.8
Time in novel zone, NPP test1.71.93.31.11.00.60.31.61.61.81.61.61.71.6-0.51.6
Total zone transitions, NPP test1.01.53.8-1.5-1.6-1.8-1.9-0.5-0.50.4-0.61.3-0.20.9-1.90.4
Total locomotion distance, NPP test1.31.84.6-1.7-1.7-2.0-2.1-0.7-0.70.1-0.71.4-0.30.8-2.10.5
Locomotion velocity, NPP test1.11.64.0-1.6-1.7-1.8-2.0-0.7-0.70.0-0.81.3-0.40.7-1.90.4
Intraocular pressure0.91.33.11.51.51.61.80.70.70.20.8-1.20.4-0.51.7-0.2
Delta distance traveled before/after self-admin0.20.20.6-0.2-0.1-0.00.1-0.4-0.4-0.6-0.3-0.6-0.4-0.80.2-0.5
Delta ambulatory time before/after self-admin0.50.61.5-0.6-0.5-0.4-0.1-0.8-0.8-1.1-0.8-1.0-0.9-1.20.2-0.8
Parametrial fat weight2.66.117.71.51.53.03.0-0.8-0.8-2.1-0.8-2.9-1.7-3.44.2-3.2
Pavlov. Cond. lever latency0.50.72.20.30.50.40.9-0.4-0.4-1.1-0.4-1.2-0.7-1.51.2-0.8
Pavlov. Cond. magazine entry latency1.72.14.7-2.0-2.2-1.6-2.1-1.5-1.5-0.7-1.50.9-1.20.2-1.5-0.5
Pavlov. Cond. change in total contacts0.40.41.4-0.5-0.6-0.8-0.90.00.00.60.20.60.30.9-1.20.6
Pavlov. Cond. index score1.01.33.4-1.4-1.6-1.3-1.8-0.7-0.70.2-0.61.3-0.31.0-1.70.3
Pavlov. Cond. latency score0.91.23.1-1.3-1.5-1.2-1.8-0.5-0.50.4-0.51.2-0.11.1-1.70.4
Pavlov. Cond. lever contacts0.30.31.2-0.3-0.5-0.1-0.70.10.10.60.10.80.31.1-0.70.3
Pavlov. Cond. magazine entry number1.51.94.71.92.01.72.21.21.20.21.1-1.30.8-0.71.7-0.0
Pavlov. Cond. intertrial magazine entries1.11.33.31.21.31.51.80.40.4-0.40.4-1.6-0.0-1.21.8-0.9
Pavlov. Cond. lever-magazine prob. diff.1.01.23.1-1.4-1.6-1.2-1.8-0.8-0.80.1-0.71.1-0.40.8-1.60.1
Pavlov. Cond. response bias1.01.33.2-1.4-1.6-1.3-1.8-0.7-0.70.2-0.71.4-0.41.0-1.50.2
Pavlov. Cond. lever latency1.82.43.5-1.8-1.8-1.0-1.1-1.8-1.8-1.9-1.7-1.3-1.8-1.7-0.4-1.6
Pavlov. Cond. magazine entry latency0.00.00.1-0.0-0.0-0.1-0.10.00.00.2-0.00.20.20.3-0.20.3
Pavlov. Cond. change in total contacts2.23.65.32.32.31.61.62.12.12.22.11.32.11.60.81.7
Pavlov. Cond. index score1.62.13.11.71.71.21.11.61.61.81.61.21.71.60.51.4
Pavlov. Cond. latency score1.62.23.51.61.51.00.91.61.61.91.61.41.81.80.21.5
Pavlov. Cond. lever contacts1.52.03.11.71.81.11.21.61.61.61.61.01.61.50.51.3
Pavlov. Cond. magazine entry number1.01.22.3-1.0-1.0-0.4-0.4-1.2-1.2-1.5-1.2-1.1-1.4-1.40.2-1.4
Pavlov. Cond. intertrial magazine entries0.30.40.8-0.7-0.6-0.8-0.5-0.7-0.7-0.6-0.7-0.1-0.9-0.3-0.1-0.7
Pavlov. Cond. lever-magazine prob. diff.1.72.33.11.81.81.21.21.71.71.81.71.01.81.40.51.5
Pavlov. Cond. response bias1.11.52.51.51.60.91.11.41.41.41.30.81.31.10.61.1
Time in closed arm before self-admin1.62.14.2-1.9-2.1-1.4-1.7-1.7-1.7-1.0-1.7-0.1-1.5-0.4-1.0-1.1
Time in closed arm after self-admin0.91.02.2-1.3-1.5-0.8-1.2-1.2-1.2-0.6-1.20.3-1.0-0.1-0.6-0.9
Time in open arm before self-admin0.50.51.40.40.30.1-0.10.70.70.90.71.10.91.2-0.40.7
Time in open arm after self-admin0.30.31.8-0.4-0.4-0.8-0.6-0.2-0.20.2-0.21.4-0.20.4-0.40.3
Bone: periosteal estimation3.26.813.21.31.2-0.1-0.42.82.83.32.83.23.23.6-2.13.5
Bone: periosteal perimeter3.15.39.41.51.40.50.12.62.63.02.42.82.93.1-1.33.0
Bone: post-yield work0.71.02.20.50.6-0.3-0.11.11.11.31.21.11.31.3-0.81.5
Progressive ratio test 1 active lever presses2.32.94.71.81.71.31.02.02.02.21.91.81.81.50.31.7
Progressive ratio test 1 breakpoint2.63.15.21.81.71.31.02.12.12.32.01.92.01.60.21.8
Progressive ratio test 1 inactive lever presses1.92.74.11.81.71.21.11.91.92.01.81.61.91.60.41.6
Progressive ratio test 2 active lever presses0.30.43.20.0-0.1-0.2-0.50.10.10.80.11.80.10.9-0.30.5
Progressive ratio test 2 breakpoint0.30.43.20.1-0.1-0.1-0.40.10.10.70.01.80.10.8-0.20.4
Progressive ratio test 2 inactive lever presses0.91.53.31.31.20.80.61.31.31.71.31.81.21.40.31.2
Incentive Sensitization - Responses2.53.55.8-2.3-2.4-2.0-2.1-2.4-2.4-1.3-2.30.8-2.0-0.2-0.9-1.3
Incentive Sensitization - Breakpoint2.33.05.2-2.1-2.2-1.7-1.9-2.3-2.3-1.2-2.20.8-2.0-0.3-0.7-1.4
Sum of active levers in priming session hrs 5-61.51.43.11.71.61.71.71.11.10.71.1-0.00.9-0.21.40.1
Progressive ratio0.81.34.4-1.5-1.1-2.1-1.2-1.0-1.0-1.0-0.9-1.1-0.9-0.7-1.2-0.0
Food seeking constrained by brief footshock0.20.20.9-0.4-0.3-1.0-0.60.10.10.20.0-0.00.20.3-0.90.6
Seeking ratio, punishment vs. effort0.40.61.31.00.81.10.80.70.70.70.60.90.60.50.70.1
Retroperitoneal fat weight2.08.720.90.20.22.22.2-2.1-2.1-3.5-2.0-4.1-3.0-4.63.8-4.1
Reaction time number correct0.10.20.70.20.10.60.4-0.3-0.3-0.2-0.4-0.2-0.5-0.20.9-0.8
Reaction time mean minus median2.76.612.9-3.5-3.5-3.6-3.6-2.7-2.7-1.3-2.51.5-1.80.4-2.7-0.7
Reaction time mean minus median AUC1.74.29.1-2.8-2.8-3.0-2.9-2.1-2.1-0.9-2.01.2-1.40.4-2.1-0.5
Reaction time num false alarms0.30.40.80.40.4-0.20.00.70.70.80.60.90.60.4-0.40.8
Reaction time num false alarms AUC0.20.40.90.30.4-0.4-0.10.70.70.80.61.00.60.4-0.60.9
Reaction time trials correct on left0.10.20.70.20.10.60.4-0.3-0.3-0.2-0.4-0.2-0.5-0.20.9-0.8
Reaction time trials on left0.10.20.60.20.10.50.3-0.3-0.3-0.2-0.4-0.2-0.5-0.10.7-0.8
Reaction time mean1.21.93.3-1.6-1.5-1.3-1.1-1.8-1.8-1.3-1.8-0.1-1.6-0.9-0.2-1.5
Reaction time mean AUC1.42.23.8-1.6-1.6-1.2-1.1-1.9-1.9-1.5-1.9-0.3-1.8-1.1-0.1-1.6
Median of all reaction times0.71.02.2-0.6-0.5-0.3-0.1-1.2-1.2-1.1-1.2-0.6-1.3-1.20.7-1.5
Reaction time omissions1.62.37.1-2.0-1.9-2.7-2.4-0.9-0.9-0.0-1.01.2-0.50.4-2.30.4
Reaction time false alarm rate0.40.61.40.40.6-0.30.01.01.00.90.90.81.00.5-0.61.2
Reaction time premature initiation rate0.91.32.71.00.80.50.31.31.31.41.21.71.41.5-0.21.3
Reaction time premature initiations0.61.02.61.00.80.70.41.01.01.20.91.61.11.40.20.8
Std. dev. reaction times2.24.18.1-2.8-2.7-2.8-2.7-2.1-2.1-1.1-2.20.8-1.6-0.1-2.0-0.7
Reaction time trials completed0.10.20.60.20.10.50.3-0.3-0.3-0.2-0.4-0.2-0.5-0.10.7-0.8
Reaction time trials AUC0.10.30.90.30.30.70.6-0.2-0.2-0.3-0.3-0.4-0.5-0.31.0-0.8
Run reversals in cocaine runway, females1.01.03.0-1.4-1.1-1.7-1.2-0.5-0.5-0.7-0.5-1.0-0.2-0.1-1.60.4
Run reversals in cocaine runway, males0.20.21.5-0.0-0.20.1-0.3-0.1-0.10.6-0.11.20.00.8-0.0-0.1
Latency to leave start box in cocaine runway0.40.51.0-0.6-0.5-0.4-0.1-0.8-0.8-1.0-0.7-1.0-0.8-1.00.1-0.7
Latency to leave start box in cocaine runway, F0.80.92.7-0.8-0.6-0.8-0.2-1.0-1.0-1.3-0.9-1.6-1.0-1.20.0-0.9
Latency to leave start box in cocaine runway, M0.10.10.30.0-0.10.50.2-0.3-0.3-0.4-0.3-0.1-0.4-0.50.6-0.4
Std. dev. time between licks in bursts0.30.40.8-0.6-0.7-0.5-0.6-0.9-0.9-0.4-0.90.6-0.9-0.10.1-0.6
Total sessions with >9 infusions0.60.71.41.21.11.01.00.90.90.70.80.50.60.30.90.6
Short access day 1 total inactive lever presses3.24.312.22.92.73.33.21.31.30.51.1-0.40.5-0.73.5-1.0
Short access day 10 total inactive lever presses0.30.71.40.80.70.70.40.90.91.21.11.00.80.90.00.6
Short access day 1 total infusions1.82.45.62.32.22.42.31.31.30.81.20.00.7-0.22.20.1
Short access day 10 total infusions0.30.40.70.70.70.80.60.80.80.50.60.10.60.60.30.4
Short access total infusions0.50.61.91.11.01.41.10.50.50.40.40.50.20.11.3-0.1
Short access day 1 locomotion0.50.61.91.01.01.41.10.50.5-0.00.2-0.30.1-0.31.2-0.1
Short access day 10 total locomotion0.10.10.20.40.30.40.50.40.40.10.3-0.30.20.20.30.3
Short access total locomotion0.30.41.10.80.71.00.80.70.70.40.50.00.50.30.60.4
One hour access (0.3 mA shock)2.93.45.42.32.21.81.72.22.22.12.11.11.91.20.91.4
Compulsive drug intake0.60.71.8-0.10.1-1.3-0.50.80.80.80.80.31.01.0-1.31.1
One hour access (shock baseline)0.60.93.01.31.11.71.10.70.70.70.60.80.50.31.20.1
Social response proportion0.30.40.70.50.60.10.20.60.60.80.90.60.80.8-0.20.6
Social responses0.70.91.50.90.90.60.51.11.11.11.20.81.20.9-0.10.8
Social time1.82.55.22.22.31.92.11.51.51.21.70.41.40.51.70.5
Soleus weight1.33.96.21.91.91.11.02.42.42.32.41.62.52.0-0.32.4
Bone: stiffness0.81.33.6-0.8-0.8-1.3-1.40.30.30.80.21.50.71.5-1.91.4
Tibialis anterior weight3.211.024.34.64.64.84.93.13.11.22.9-1.72.0-0.44.10.1
Time to tail flick, vehicle, before self-admin0.50.51.2-0.5-0.5-1.0-1.00.00.00.70.01.10.30.7-1.10.7
Time to tail flick, vehicle, after self-admin1.01.43.1-0.1-0.2-0.6-0.91.01.01.41.01.01.31.8-1.81.6
Time to tail flick, test, before self-admin0.30.31.20.60.51.10.80.10.1-0.0-0.0-0.1-0.1-0.51.0-0.7
Time to tail flick, test, after self-admin1.21.22.81.61.71.31.51.21.20.71.20.00.9-0.11.10.4
Delta time to tail flick, vehicle, before/after SA0.50.41.3-0.0-0.0-0.4-0.40.60.60.60.60.30.80.9-1.01.1
Delta time to tail flick, test, before/after SA0.10.10.40.10.3-0.40.00.30.30.00.3-0.20.3-0.0-0.30.6
Tibia length1.43.97.02.12.01.61.42.72.72.02.60.22.61.4-0.12.2
Ambulatory time before self-admin0.20.31.00.10.0-0.1-0.30.50.50.80.50.60.71.0-0.60.7
Ambulatory time after self-admin0.40.51.6-0.2-0.20.00.2-0.6-0.6-0.9-0.5-1.3-0.6-1.10.5-0.8
Bone: tissue strength0.30.30.7-0.2-0.20.10.2-0.6-0.6-0.7-0.7-0.4-0.7-0.60.6-0.9
Total heroin consumption2.32.75.12.22.32.02.11.81.81.21.8-0.61.40.41.40.7
Bone: trabecular number1.93.17.62.42.32.72.71.31.30.31.1-1.00.7-0.92.6-0.5
Bone: trabecular spacing4.56.09.7-3.1-3.1-2.4-2.5-2.9-2.9-2.5-2.8-1.0-2.6-1.6-1.3-1.8
Bone: trabecular thickness1.51.94.01.92.01.71.91.51.50.91.5-0.51.10.01.30.5
Bone: trabecular tissue density1.32.04.9-1.8-1.8-2.2-2.2-0.8-0.80.1-0.91.2-0.31.0-2.20.7
Water consumed over 24 hours0.60.82.41.11.11.61.50.40.4-0.30.4-0.80.2-0.61.5-0.3
Number of responses in last shaping day0.50.62.01.00.91.41.10.60.60.40.6-0.10.3-0.21.10.2