Hub : Genes

Fxyd5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fxyd5 0.05 0.04 8.2e-03 0.01 0.02 0.01 0.01 1.9e-02 1.0e-02 2.6e-02 3.5e-02
2 NAcc gene expression Fxyd5 0.17 0.08 2.8e-16 0.08 0.11 0.11 0.12 5.2e-12 9.8e-17 6.6e-17 5.5e-17
3 IC gene expression Fxyd5 0.31 0.14 2.3e-06 0.14 0.13 0.14 0.13 1.1e-06 5.2e-06 2.1e-06 3.5e-06
4 Adipose gene expression Fxyd5 0.06 0.04 1.5e-06 0.01 0.02 0.01 0.01 3.3e-02 1.7e-03 7.0e-02 2.6e-02
5 PL gene expression Fxyd5 0.26 0.13 2.5e-09 0.09 0.09 0.09 0.09 9.3e-10 2.1e-10 7.0e-10 1.0e-09
6 OFC mRNA stability Fxyd5 0.2 0.13 2.4e-03 0.06 0.07 0.08 0.07 1.3e-02 1.0e-02 6.8e-03 8.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.91.62.3-1.5-1.0-1.31.5-0.4-1.5
Area under the delay curve0.60.71.8-0.5-1.1-0.9-0.1-1.30.4
BMI with tail0.10.30.70.0-0.4-0.2-0.4-0.80.8
BMI without tail0.31.12.1-1.0-1.2-1.20.5-1.4-0.1
Body weight3.314.520.9-4.6-3.2-4.53.9-3.1-3.4
Weight adjusted by age0.10.20.4-0.2-0.6-0.50.2-0.2-0.4
Bone surface1.42.53.9-1.7-2.0-1.71.1-1.4-1.4
Bone volume1.73.14.0-2.0-2.0-2.01.5-1.3-1.7
Breakpoint value in progressive ratio session0.91.11.7-1.1-1.3-1.30.5-1.3-0.2
Number of licking bursts1.83.05.32.00.61.8-2.30.52.2
Context. condit. distance diff. score0.30.30.80.1-0.7-0.1-0.7-0.90.5
Locomotion velocity, session 10.10.20.80.20.30.20.10.9-0.1
Locomotion distance, session 11.41.86.0-1.0-2.4-1.60.1-1.2-0.4
Locomotion velocity, session 20.60.71.11.00.30.9-1.01.00.8
Locomotion distance, session 21.21.73.40.9-1.70.2-1.8-0.11.7
Locomotion velocity, session 30.30.30.70.6-0.70.2-0.80.40.4
Locomotion distance, session 33.84.211.4-1.6-3.4-2.1-0.0-2.5-0.3
Stereotopy head waving bouts, day 31.61.95.50.82.41.10.41.9-0.2
Stereotopy head waving duration, day 32.32.87.31.32.71.50.02.30.2
Locomotion velocity, session 71.01.13.7-0.9-1.9-0.80.0-1.3-0.0
Locomotion distance, session 70.50.62.1-0.8-1.4-0.40.3-0.5-0.6
Stereotopy head waving bouts, day 72.02.23.41.80.81.7-1.80.51.7
Stereotopy head waving duration, day 71.92.23.21.81.51.5-1.50.91.6
Locomotion velocity, session 82.83.46.12.10.12.0-2.50.62.3
Locomotion distance, session 81.31.94.30.9-1.60.5-2.1-0.81.6
Degree of sensitization distance1.11.23.30.41.81.20.51.3-0.5
Degree of sensitization stereotypy1.82.04.01.60.31.4-2.0-0.01.8
Conditioned locomotion0.50.51.40.80.50.5-0.8-0.11.2
Cocaine response after cond. corrected0.60.72.20.11.50.30.81.1-0.5
Cocaine response after cond. not corrected1.21.43.80.21.90.50.91.6-0.9
Cocaine response before conditioning0.40.41.8-0.6-0.2-0.30.40.1-1.3
Saline control response0.20.20.70.30.60.40.00.9-0.1
Bone: connectivity density0.20.41.1-0.6-1.0-0.50.4-0.2-0.5
Bone: cortical apparent density0.30.51.10.8-0.10.5-0.90.41.0
Bone: cortical area1.52.23.2-1.7-1.2-1.71.6-0.7-1.8
Bone: cortical porosity2.22.45.51.80.21.4-2.30.21.9
Bone: cortical porosity2.73.06.61.90.21.6-2.60.22.2
Bone: cortical thickness0.81.32.0-1.2-0.6-1.41.4-0.2-1.4
Bone: cortical thickness0.20.20.60.40.50.0-0.10.80.2
Bone: cortical tissue density0.50.61.50.9-0.10.6-1.00.31.2
Condit. Reinf. active minus inactive responses0.10.10.30.4-0.10.1-0.40.20.5
Condit. Reinf. active-inactive response ratio0.30.31.00.40.90.20.41.0-0.0
Condit. Reinf. active responses1.11.33.31.30.10.9-1.40.31.8
Condit. Reinf. inactive responses1.61.95.01.2-0.50.9-2.0-0.32.2
Incentive salience index mean0.20.20.60.4-0.50.1-0.60.00.8
Condit. Reinf. lever presses0.20.30.60.1-0.60.0-0.6-0.50.8
Condit. Reinf. active minus inactive responses0.60.81.4-0.8-1.2-1.10.6-0.3-0.9
Condit. Reinf. active-inactive response ratio0.10.10.20.3-0.1-0.1-0.20.50.1
Condit. Reinf. active responses1.52.13.5-1.6-1.9-1.61.0-1.1-1.4
Condit. Reinf. inactive responses1.62.13.9-1.6-1.8-1.30.6-2.0-1.0
Condit. Reinf. lever presses4.05.57.5-2.7-2.1-2.72.2-1.5-2.6
Condit. Reinf. lever reinforcers received1.92.65.0-1.7-2.2-1.70.9-1.4-1.4
Conditioned reinforcement - actives0.40.81.30.90.81.2-0.61.20.4
Conditioned reinforcement - inactives1.01.53.2-0.0-1.8-0.1-1.2-1.51.3
Conditioned locomotion1.62.13.81.51.21.9-1.40.91.6
Patch foraging indifference point 0 sec0.00.10.10.30.10.3-0.40.20.1
Patch foraging indifference point AUC0.40.60.80.70.90.9-0.50.60.8
Delay disc. indifference point, 0s delay2.12.45.6-1.0-2.2-1.4-0.2-2.40.8
Delay disc. indifference point, 16s delay0.70.72.3-0.6-0.9-0.8-0.0-1.50.5
Delay disc. indifference point, 2s delay2.22.45.0-1.6-2.2-1.70.6-2.0-0.2
Delay disc. indifference point, 24s delay1.61.83.0-1.4-1.6-1.50.8-1.7-0.5
Delay disc. indifference point, 4s delay0.40.40.80.3-0.70.2-0.9-0.50.8
Delay disc. indifference point, 8s delay0.00.10.2-0.1-0.1-0.3-0.1-0.4-0.1
Indifference point function ln k0.40.71.9-0.5-1.4-1.20.2-0.2-0.6
Indifference point function log k0.40.71.9-0.5-1.4-1.20.2-0.2-0.6
Patch foraging total patch changes 0 sec0.00.00.10.2-0.10.3-0.30.00.0
Patch foraging total patch changes 12 sec0.40.61.00.71.00.9-0.31.00.1
Patch foraging total patch changes 18 sec0.20.30.60.50.60.8-0.7-0.20.5
Patch foraging total patch changes 24 sec0.30.61.9-0.8-0.5-0.50.3-1.4-0.3
Patch foraging total patch changes 6 sec0.20.30.70.30.70.8-0.10.50.1
Patch foraging time to switch 0 sec0.91.86.01.12.51.5-0.21.00.5
Patch foraging water rate 0 sec0.30.71.30.8-0.80.5-1.10.61.0
Patch foraging water rate 12 sec0.30.72.9-0.5-1.7-0.2-0.4-0.6-0.5
Patch foraging water rate 18 sec0.10.20.30.4-0.30.6-0.50.50.2
Patch foraging water rate 24 sec1.52.27.00.2-2.7-0.3-1.7-1.31.1
Patch foraging water rate 6 sec1.52.28.3-1.1-2.9-1.0-0.2-1.6-0.3
Seeking ratio, delayed vs. immediate footshock1.82.25.3-1.2-2.3-1.60.1-2.0-0.2
Distance traveled before self-admin0.00.00.1-0.2-0.20.2-0.0-0.30.0
Distance traveled after self-admin0.81.02.0-1.2-0.6-1.01.0-0.6-1.4
Extensor digitorum longus weight0.31.02.7-0.80.6-1.41.60.3-0.6
Bone: elastic displacement0.30.31.10.01.00.20.40.6-0.5
Bone: elastic work1.51.92.9-1.7-0.5-1.51.7-0.9-1.5
Bone: endosteal estimation0.71.52.4-1.5-1.0-1.11.2-0.8-1.6
Bone: endosteal perimeter0.61.21.8-1.3-1.3-1.00.8-1.1-1.1
Epididymis fat weight0.10.50.7-0.9-0.9-0.90.6-0.5-0.4
Delta time in closed arm before/after self-admin1.21.11.9-1.1-1.0-1.40.9-0.8-1.0
Delta time in open arm before/after self-admin0.80.81.11.01.10.9-0.71.00.3
Diff in mean of infusions in LGA sessions0.60.71.90.90.70.6-0.9-0.21.4
Delay discount exponential model param0.50.61.50.61.00.9-0.11.2-0.2
Extinction: sum of active levers before priming4.14.57.9-2.5-0.5-2.42.8-1.0-2.4
Active lever presses in extinction session 62.42.45.3-1.20.9-0.82.31.0-2.2
Bone: final force1.72.85.1-1.8-1.5-2.31.6-1.2-1.5
Bone: final moment2.33.86.7-2.1-1.6-2.61.9-1.3-1.8
Food consumed during 24 hour testing period0.60.82.1-0.4-1.4-0.7-0.4-1.30.0
Glucose0.40.61.90.51.00.40.21.4-0.6
Heart weight0.20.41.60.0-1.3-0.1-0.6-0.20.3
Delay discount hyperbolic model param0.50.61.40.51.00.8-0.01.2-0.3
Intermittent access intake day 1-15 change1.53.24.6-2.1-1.3-2.01.9-1.6-1.6
Intermittent access intake escalation1.42.84.0-2.0-1.2-1.91.9-1.2-1.7
Intermittent access intake escalation 21.01.12.1-1.2-0.2-1.01.4-0.3-1.5
Intermitt. access day 1 inactive lever presses0.83.15.9-1.9-2.1-1.90.9-2.4-0.6
Intermitt. access day 15 inactive lever presses0.81.64.2-0.8-1.8-0.9-0.3-2.00.6
Intermitt. access escalation Index0.30.41.30.6-0.50.1-1.1-0.50.8
Intermittent access day 1 total infusions2.03.27.11.9-0.01.9-2.70.12.2
Intermittent access day 15 total infusions0.30.41.1-0.1-1.1-0.0-0.7-0.90.5
Intermittent access terminal intake (last 3 days)0.70.92.20.7-0.60.7-1.5-0.71.2
Intermittent access total infusions0.91.13.01.0-0.30.8-1.7-0.51.3
Intermittent access day 1 locomotion2.22.86.41.4-0.71.4-2.5-0.82.3
Intermittent access day 15 total locomotion0.40.71.60.0-1.00.4-0.9-1.30.9
Intermittent access total locomotion1.31.53.21.1-0.11.2-1.8-0.41.8
Intermittent access standard deviation1.22.64.3-1.8-1.6-1.81.0-2.1-1.2
Left kidney weight2.611.917.6-4.2-2.5-3.83.9-2.4-3.6
Right kidney weight3.013.719.7-4.4-2.6-4.04.3-2.0-4.1
Cocaine induced anxiety0.20.30.7-0.7-0.1-0.50.8-0.4-0.1
Post-drug Anxiety0.20.20.5-0.20.2-0.30.2-0.70.7
Baseline Anxiety0.40.40.80.4-0.20.1-0.9-0.80.9
Tail length4.015.622.1-4.7-3.3-4.53.9-3.0-4.0
Length with tail5.323.233.1-5.8-4.0-5.34.9-3.5-5.0
Length without tail3.210.414.6-3.8-3.0-3.73.2-2.1-3.2
Times rat made contact with spout0.30.31.10.20.70.00.31.0-0.6
Lifetime Intake0.91.12.81.2-0.11.0-1.70.11.1
Liver weight, left0.50.71.11.00.80.9-0.81.00.5
Liver weight, right0.20.31.70.4-0.10.4-0.11.30.2
Locomotor activity1.32.16.01.01.81.50.02.4-0.3
Locomotor testing distance1.12.14.91.21.71.7-0.52.2-0.0
Locomotor testing rearing1.22.33.61.71.21.9-1.31.90.8
Locomotion in novel chamber0.50.71.50.91.20.8-0.21.00.3
Locomotion in novel chamber post-restriction0.20.30.50.50.70.6-0.30.50.5
Fecal boli incidents, locomotor time 12.43.44.82.02.22.1-1.21.81.7
Change in fecal boli incidents, locomotor task0.70.71.2-0.31.0-0.11.11.1-0.8
Time >=10cm from walls, locomotor time 10.10.10.10.30.30.2-0.20.40.2
Bouts of movement, locomotor time 11.21.44.0-0.8-2.0-0.6-0.4-1.70.3
Total resting periods, locomotor time 10.80.92.4-0.6-1.6-0.4-0.3-1.40.3
Rest time, locomotor task time 11.21.52.51.21.41.4-0.70.81.6
Distance moved, locomotor task time 10.10.20.6-0.1-0.8-0.4-0.2-0.3-0.4
Vertical activity count, locomotor time 10.61.32.1-1.2-1.4-1.20.5-1.2-1.1
Time >=10cm from walls, locomotor time 21.21.82.51.60.81.5-1.51.01.5
Bouts of movement, locomotor time 20.10.10.30.2-0.50.4-0.50.1-0.1
Total resting periods, locomotor time 20.20.30.60.6-0.10.8-0.70.50.1
Rest time, locomotor task time 20.70.81.20.91.11.1-0.50.90.8
Distance moved, locomotor task time 20.20.31.00.0-1.0-0.4-0.5-0.50.2
Vertical activity count, locomotor time 20.91.22.7-1.0-1.6-1.10.3-1.3-0.5
Light reinforcement 10.10.30.90.6-0.30.4-0.90.00.6
Light reinforcement 20.91.52.61.50.30.7-1.41.11.6
Bone: marrow area0.71.42.6-1.4-0.9-1.11.2-0.7-1.6
Bone: maximum diameter1.01.82.7-1.6-1.0-1.41.4-1.0-1.4
Bone: maximum force2.64.67.0-2.4-2.0-2.61.9-1.7-2.0
Bone: maximum moment3.15.58.2-2.7-2.2-2.92.2-1.8-2.2
Mean time between licks in bursts0.20.51.80.2-1.4-0.3-0.8-0.40.7
Mean num. licks in bursts1.62.54.8-1.7-0.3-1.62.20.1-2.2
Cd content in liver0.10.10.60.30.80.40.00.10.1
Co content in liver0.50.61.90.61.40.80.00.80.3
Cu content in liver1.41.72.4-1.6-1.4-1.51.2-1.0-1.0
Fe content in liver0.40.50.70.80.80.7-0.60.80.6
K content in liver0.10.10.10.20.20.4-0.10.40.1
Mg content in liver0.80.82.50.81.10.7-0.11.60.2
Mn content in liver2.12.36.21.22.51.4-0.12.00.0
Na content in liver0.20.20.5-0.5-0.2-0.20.3-0.3-0.7
Rb content in liver0.20.20.70.10.30.1-0.2-0.50.9
Se content in liver3.33.96.52.12.12.1-1.12.51.5
Sr content in liver1.21.02.00.91.41.2-0.31.30.1
Zn content in liver1.21.32.61.11.60.9-0.41.41.0
Bone: minimum diameter1.83.25.6-2.0-2.4-1.61.1-2.1-1.3
Time in familiar zone, hab. session 12.01.94.0-1.6-0.8-1.52.00.1-1.6
Time in novel zone, hab. session 13.53.56.42.21.02.1-2.50.42.1
Total zone transitions, hab. session 10.40.51.70.1-1.3-0.4-0.8-0.50.5
Total locomotion distance, hab. session 10.10.10.40.1-0.70.1-0.50.0-0.4
Locomotion velocity, hab. session 10.10.10.30.2-0.10.1-0.30.4-0.5
Time in familiar zone, hab. session 20.91.02.3-0.80.8-0.21.50.3-1.4
Time in novel zone, hab. session 20.40.41.10.8-0.30.2-1.10.20.9
Total zone transitions, hab. session 22.73.46.52.20.21.8-2.51.12.1
Total locomotion distance, hab. session 21.11.53.51.4-0.01.4-1.90.41.1
Locomotion velocity, hab. session 21.01.43.01.40.11.3-1.70.51.1
Novel to familiar place preference ratio0.10.10.3-0.3-0.3-0.10.0-0.5-0.0
Novelty place preference0.10.10.2-0.1-0.20.2-0.2-0.50.1
Time in novel zone, NPP test0.10.10.20.1-0.20.3-0.4-0.40.3
Total zone transitions, NPP test0.20.31.2-0.0-1.1-0.5-0.3-0.10.0
Total locomotion distance, NPP test0.91.22.8-1.1-1.2-1.10.8-0.4-1.7
Locomotion velocity, NPP test0.81.12.9-1.1-0.9-1.00.9-0.3-1.7
Intraocular pressure0.20.30.50.60.70.3-0.7-0.40.7
Delta distance traveled before/after self-admin1.31.42.3-1.3-0.7-1.51.1-0.8-1.5
Delta ambulatory time before/after self-admin1.21.52.5-1.3-1.0-1.61.0-1.0-1.4
Parametrial fat weight0.81.93.7-0.21.90.01.71.8-1.1
Pavlov. Cond. lever latency0.60.81.8-1.00.3-1.01.3-0.6-0.7
Pavlov. Cond. magazine entry latency2.43.04.82.10.32.0-2.02.20.7
Pavlov. Cond. change in total contacts1.92.04.81.5-0.81.4-2.20.41.4
Pavlov. Cond. index score1.82.33.81.80.01.8-1.91.60.9
Pavlov. Cond. latency score1.31.73.31.6-0.31.5-1.81.20.9
Pavlov. Cond. lever contacts0.50.61.40.9-0.30.9-1.20.60.5
Pavlov. Cond. magazine entry number1.82.34.1-1.90.1-1.82.0-1.6-0.8
Pavlov. Cond. intertrial magazine entries0.10.10.40.10.1-0.1-0.00.10.7
Pavlov. Cond. lever-magazine prob. diff.2.43.04.82.10.12.0-2.21.81.0
Pavlov. Cond. response bias1.62.04.01.70.41.6-1.52.00.3
Pavlov. Cond. lever latency3.54.86.32.52.52.5-1.62.01.8
Pavlov. Cond. magazine entry latency1.41.72.5-1.6-1.3-1.41.1-1.1-1.3
Pavlov. Cond. change in total contacts4.26.89.5-3.1-2.6-2.82.0-2.7-2.3
Pavlov. Cond. index score3.44.66.4-2.5-2.2-2.41.7-1.9-2.1
Pavlov. Cond. latency score2.83.75.2-2.3-2.0-2.11.5-1.7-1.8
Pavlov. Cond. lever contacts3.95.47.3-2.7-2.6-2.71.7-2.2-1.9
Pavlov. Cond. magazine entry number3.03.75.22.32.02.1-1.61.41.9
Pavlov. Cond. intertrial magazine entries0.60.91.90.91.41.1-0.60.40.9
Pavlov. Cond. lever-magazine prob. diff.3.14.15.9-2.4-2.0-2.21.7-1.6-2.1
Pavlov. Cond. response bias4.96.78.9-2.9-3.0-3.01.8-2.5-2.1
Time in closed arm before self-admin1.11.42.71.10.61.3-1.5-0.21.7
Time in closed arm after self-admin0.50.51.4-0.0-0.8-0.4-0.6-1.20.8
Time in open arm before self-admin2.62.95.8-1.9-0.9-1.62.1-0.2-2.4
Time in open arm after self-admin0.70.82.5-0.70.2-0.41.10.6-1.6
Bone: periosteal estimation1.53.14.5-2.1-1.5-1.81.8-1.0-2.1
Bone: periosteal perimeter0.61.02.2-1.1-0.6-0.81.1-0.3-1.5
Bone: post-yield work1.62.45.3-1.6-2.3-1.50.5-1.9-0.7
Progressive ratio test 1 active lever presses0.30.40.90.0-0.80.2-0.8-0.90.6
Progressive ratio test 1 breakpoint0.40.51.00.0-0.90.1-0.8-1.00.6
Progressive ratio test 1 inactive lever presses1.62.35.00.2-2.2-0.4-1.8-1.81.5
Progressive ratio test 2 active lever presses0.10.10.10.1-0.40.2-0.4-0.10.3
Progressive ratio test 2 breakpoint0.10.10.30.2-0.40.4-0.5-0.00.4
Progressive ratio test 2 inactive lever presses1.42.25.2-0.6-2.1-1.2-0.7-2.31.2
Incentive Sensitization - Responses0.10.10.20.2-0.40.2-0.40.10.5
Incentive Sensitization - Breakpoint0.10.10.20.2-0.40.2-0.4-0.00.5
Sum of active levers in priming session hrs 5-60.00.00.1-0.00.3-0.10.20.10.1
Progressive ratio0.30.40.80.80.10.7-0.90.50.5
Food seeking constrained by brief footshock0.60.81.4-1.0-1.0-0.80.7-0.4-1.2
Seeking ratio, punishment vs. effort0.40.61.2-0.9-1.1-0.80.5-0.8-0.4
Retroperitoneal fat weight1.14.913.70.83.11.51.33.7-1.2
Reaction time number correct0.10.10.4-0.4-0.6-0.20.30.1-0.2
Reaction time mean minus median0.20.40.8-0.70.1-0.60.9-0.5-0.8
Reaction time mean minus median AUC0.51.22.2-1.3-0.3-0.91.5-0.6-1.4
Reaction time num false alarms0.81.12.01.11.11.4-0.90.51.0
Reaction time num false alarms AUC1.21.93.61.41.51.9-1.10.81.2
Reaction time trials correct on left0.10.10.4-0.4-0.6-0.20.30.1-0.2
Reaction time trials on left0.10.10.3-0.4-0.6-0.20.30.2-0.3
Reaction time mean0.10.20.4-0.4-0.5-0.50.2-0.4-0.6
Reaction time mean AUC0.00.10.3-0.2-0.3-0.20.2-0.1-0.5
Median of all reaction times0.00.10.20.1-0.4-0.1-0.3-0.1-0.2
Reaction time omissions0.20.31.00.30.70.20.21.0-0.6
Reaction time false alarm rate1.01.42.51.31.41.6-1.10.51.1
Reaction time premature initiation rate0.30.51.00.50.10.8-1.0-0.40.8
Reaction time premature initiations0.20.30.60.3-0.20.6-0.8-0.40.7
Std. dev. reaction times0.40.70.9-0.9-0.6-0.80.7-1.0-0.9
Reaction time trials completed0.10.10.3-0.4-0.6-0.20.30.2-0.3
Reaction time trials AUC0.10.10.2-0.3-0.3-0.10.50.4-0.4
Run reversals in cocaine runway, females1.41.42.3-1.3-1.5-1.20.7-1.5-0.5
Run reversals in cocaine runway, males1.91.95.50.41.80.61.02.4-1.1
Latency to leave start box in cocaine runway1.11.23.1-1.2-1.2-1.00.5-1.80.0
Latency to leave start box in cocaine runway, F1.01.13.1-0.6-1.8-1.0-0.2-1.40.5
Latency to leave start box in cocaine runway, M0.20.20.6-0.30.60.20.2-0.7-0.1
Std. dev. time between licks in bursts1.01.33.31.0-0.80.9-1.8-0.31.3
Total sessions with >9 infusions1.11.32.31.30.51.5-1.11.50.4
Short access day 1 total inactive lever presses2.83.710.3-0.9-3.2-1.1-0.9-2.81.1
Short access day 10 total inactive lever presses1.94.710.1-1.9-3.2-2.30.4-3.10.1
Short access day 1 total infusions0.30.41.10.4-1.10.3-0.90.30.3
Short access day 10 total infusions0.50.71.21.00.71.1-1.00.60.4
Short access total infusions0.91.11.81.30.41.3-1.21.20.5
Short access day 1 locomotion0.60.71.11.00.40.8-1.00.80.8
Short access day 10 total locomotion0.30.51.40.4-0.50.6-1.2-0.60.6
Short access total locomotion1.82.23.61.70.61.7-1.90.91.4
One hour access (0.3 mA shock)0.91.03.4-0.3-1.8-0.3-0.9-1.30.3
Compulsive drug intake0.60.71.80.2-1.30.4-1.0-0.60.8
One hour access (shock baseline)0.10.20.40.2-0.50.0-0.7-0.40.3
Social response proportion1.21.32.0-1.4-0.9-1.41.1-1.3-0.7
Social responses0.10.20.3-0.6-0.2-0.40.5-0.4-0.0
Social time2.02.85.3-1.7-2.3-1.90.8-1.7-1.0
Soleus weight0.00.10.2-0.10.5-0.40.40.4-0.1
Bone: stiffness1.82.94.8-1.8-2.0-2.21.3-1.5-1.1
Tibialis anterior weight0.41.53.1-0.81.0-1.51.80.5-1.2
Time to tail flick, vehicle, before self-admin0.30.30.50.4-0.50.7-0.70.20.5
Time to tail flick, vehicle, after self-admin0.20.30.90.61.00.5-0.30.4-0.1
Time to tail flick, test, before self-admin1.41.53.7-0.5-1.9-0.6-0.6-1.90.7
Time to tail flick, test, after self-admin0.10.10.10.3-0.10.1-0.30.10.4
Delta time to tail flick, vehicle, before/after SA0.10.10.40.00.7-0.10.1-0.1-0.5
Delta time to tail flick, test, before/after SA1.92.05.21.12.01.20.12.3-0.2
Tibia length3.08.212.0-3.2-3.2-3.52.4-2.2-2.5
Ambulatory time before self-admin0.00.10.3-0.2-0.10.20.0-0.50.2
Ambulatory time after self-admin2.12.53.4-1.9-1.3-1.81.4-1.6-1.5
Bone: tissue strength2.62.74.9-1.7-2.0-1.80.8-2.2-0.7
Total heroin consumption0.60.71.6-0.6-1.2-0.9-0.0-1.30.2
Bone: trabecular number1.52.53.8-1.8-1.9-1.81.4-1.2-1.4
Bone: trabecular spacing0.50.72.40.31.50.70.30.9-0.7
Bone: trabecular thickness0.50.61.0-0.8-1.0-1.00.5-0.8-0.2
Bone: trabecular tissue density1.92.87.01.12.71.30.32.6-0.3
Water consumed over 24 hours0.71.01.9-1.1-0.9-1.40.9-0.4-1.1
Number of responses in last shaping day0.20.21.10.0-1.10.0-0.50.0-0.2