Fscn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Fscn2	0.02	0.02	4.2e-03	0.02	0.02	0.01	0.02	1.9e-03	5.4e-03	1.7e-02	4.4e-03
2	Adipose	mRNA stability	Fscn2	0.03	0.03	1.1e-03	0.03	0.02	0.03	0.03	3.3e-04	1.6e-03	2.1e-04	4.5e-04
3	BLA	mRNA stability	Fscn2	0.08	0.05	4.5e-03	0.03	0.01	0	0.01	1.1e-02	6.4e-02	1.9e-01	6.3e-02
4	Brain	gene expression	Fscn2	0.08	0.07	3.8e-03	0.05	0.03	0.04	0.04	3.0e-05	8.9e-04	1.8e-04	7.1e-05
5	BLA	gene expression	Fscn2	0.08	0.05	1.4e-03	0.07	0.05	0.04	0.06	1.7e-04	8.3e-04	1.9e-03	3.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.7	0.6	0.2	-0.1	-0.0	-0.8
Area under the delay curve	1.4	1.5	2.4	-1.6	-1.4	-1.3	0.9	0.6
BMI with tail	0.4	1.3	3.6	1.9	1.0	0.4	-0.5	-1.3
BMI without tail	4.1	8.5	18.0	4.1	2.7	0.4	-0.4	-4.2
Body weight	2.7	11.2	23.6	4.9	3.7	2.8	-2.1	-2.6
Weight adjusted by age	2.1	2.4	3.8	1.9	1.7	1.6	-1.7	-0.2
Bone surface	0.2	0.3	0.6	0.8	0.6	0.5	-0.4	-0.4
Bone volume	0.2	0.3	0.6	0.8	0.6	0.3	-0.3	-0.6
Breakpoint value in progressive ratio session	0.8	0.8	2.2	0.5	1.0	1.5	-0.5	0.7
Number of licking bursts	0.2	0.2	0.6	0.6	0.1	-0.4	0.2	-0.8
Context. condit. distance diff. score	1.3	1.6	4.3	1.0	-0.0	-1.1	1.2	-2.1
Locomotion velocity, session 1	1.9	2.0	5.0	-2.0	-0.9	-0.1	-0.2	2.2
Locomotion distance, session 1	2.6	3.3	4.7	-1.9	-2.2	-2.1	2.0	-0.1
Locomotion velocity, session 2	3.1	3.6	7.1	-2.7	-2.2	-1.4	1.4	1.6
Locomotion distance, session 2	0.9	1.2	2.1	-0.7	-1.0	-1.4	1.3	-0.8
Locomotion velocity, session 3	1.4	1.6	2.9	-1.7	-1.2	-0.4	0.9	1.7
Locomotion distance, session 3	2.4	2.6	3.9	-2.0	-1.9	-1.1	1.6	1.2
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-1.0	-0.6	-0.1	0.5	1.1
Stereotopy head waving duration, day 3	0.4	0.4	0.8	-0.8	-0.6	-0.3	0.9	0.6
Locomotion velocity, session 7	0.5	0.6	1.2	-0.8	-1.1	-0.7	0.5	0.4
Locomotion distance, session 7	3.1	3.9	6.5	-1.8	-2.3	-2.6	2.0	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.6	0.2	0.3	0.2	-0.3
Stereotopy head waving duration, day 7	0.2	0.3	0.8	0.9	0.5	0.7	0.1	-0.2
Locomotion velocity, session 8	1.1	1.3	2.6	-0.6	-1.1	-1.6	1.0	-1.1
Locomotion distance, session 8	2.6	3.8	8.2	0.7	-0.9	-2.2	2.2	-2.9
Degree of sensitization distance	0.6	0.6	1.9	0.8	0.5	-0.5	-0.4	-1.4
Degree of sensitization stereotypy	0.3	0.3	1.0	1.0	0.4	0.4	-0.0	-0.6
Conditioned locomotion	2.9	3.4	6.8	2.6	1.8	0.7	-0.9	-2.3
Cocaine response after cond. corrected	0.2	0.2	0.5	-0.4	0.2	0.5	-0.5	0.7
Cocaine response after cond. not corrected	0.3	0.3	0.9	-0.9	-0.3	0.0	-0.1	0.8
Cocaine response before conditioning	0.9	1.1	1.7	-1.0	-1.3	-1.2	1.2	-0.1
Saline control response	2.0	2.6	5.0	2.2	1.9	1.3	-0.9	-1.4
Bone: connectivity density	0.3	0.5	1.1	0.1	-0.5	-0.9	0.7	-1.0
Bone: cortical apparent density	1.8	2.4	4.6	-2.1	-1.6	-1.0	1.1	1.5
Bone: cortical area	5.2	7.9	11.7	3.4	3.1	2.8	-3.0	-1.2
Bone: cortical porosity	3.5	3.8	6.5	0.6	1.6	2.6	-2.4	1.9
Bone: cortical porosity	3.0	3.2	5.6	0.9	1.6	2.4	-2.2	1.4
Bone: cortical thickness	5.2	8.5	12.6	3.1	3.2	3.2	-3.5	-0.3
Bone: cortical thickness	1.8	2.1	3.3	1.5	1.5	1.6	-1.8	-0.2
Bone: cortical tissue density	2.1	2.7	5.3	-2.3	-1.8	-1.1	1.2	1.6
Condit. Reinf. active minus inactive responses	2.0	2.2	3.5	1.9	1.6	1.0	-1.5	-1.2
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.6	1.3	1.0	0.8	-1.0	-0.7
Condit. Reinf. active responses	3.2	4.0	6.8	2.6	2.2	1.3	-1.8	-1.9
Condit. Reinf. inactive responses	0.9	1.0	1.5	1.2	1.2	0.5	-0.9	-1.0
Incentive salience index mean	1.5	1.8	3.2	1.8	1.3	0.8	-1.3	-1.3
Condit. Reinf. lever presses	0.2	0.2	0.6	0.3	-0.3	-0.5	0.2	-0.8
Condit. Reinf. active minus inactive responses	0.5	0.7	1.3	1.0	1.1	0.4	-0.3	-1.0
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.6	1.4	1.9	1.4	-1.2	-0.5
Condit. Reinf. active responses	0.2	0.3	0.8	0.4	0.6	-0.2	0.1	-0.9
Condit. Reinf. inactive responses	0.5	0.6	0.9	-0.7	-0.8	-1.0	0.9	-0.2
Condit. Reinf. lever presses	0.2	0.3	1.0	0.5	0.3	-0.3	0.2	-1.0
Condit. Reinf. lever reinforcers received	0.2	0.3	1.1	0.5	0.4	-0.3	0.3	-1.1
Conditioned reinforcement - actives	0.6	0.6	1.4	0.3	-0.3	-1.2	0.6	-0.9
Conditioned reinforcement - inactives	0.8	0.9	1.8	1.0	1.3	0.7	-1.1	-0.5
Conditioned locomotion	0.1	0.1	0.3	0.5	-0.0	-0.1	0.2	-0.6
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.4	0.1	0.3	0.3	0.0
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.1	0.1	-0.3	0.3	-0.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	-0.4	-0.3	0.3	0.1
Delay disc. indifference point, 16s delay	2.8	2.9	5.1	-1.3	-1.9	-2.3	2.0	-0.3
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	-0.8	-0.6	-0.5	0.3	0.6
Delay disc. indifference point, 24s delay	3.5	3.4	7.0	-2.6	-2.0	-1.3	0.6	2.0
Delay disc. indifference point, 4s delay	0.3	0.4	0.7	-0.8	-0.5	-0.4	0.7	0.4
Delay disc. indifference point, 8s delay	0.6	0.6	1.5	-1.2	-0.7	-0.4	-0.2	1.0
Indifference point function ln k	0.6	0.9	1.6	-1.0	-1.3	-0.9	0.8	0.6
Indifference point function log k	0.6	0.9	1.6	-1.0	-1.3	-0.9	0.8	0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.4	0.1	0.2	0.4	-0.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.0	0.4	0.4	0.0	0.2
Patch foraging total patch changes 18 sec	0.7	0.8	2.7	-0.1	-0.4	-1.0	1.6	-0.6
Patch foraging total patch changes 24 sec	0.3	0.4	1.0	1.0	0.5	0.5	-0.2	-0.4
Patch foraging total patch changes 6 sec	0.3	0.4	0.7	0.7	0.8	0.8	-0.3	-0.1
Patch foraging time to switch 0 sec	0.2	0.4	0.7	-0.8	-0.7	-0.3	0.2	0.8
Patch foraging water rate 0 sec	1.3	2.1	4.3	2.1	1.6	0.7	-0.4	-1.8
Patch foraging water rate 12 sec	0.5	0.8	1.9	0.7	0.1	-0.7	1.0	-1.4
Patch foraging water rate 18 sec	0.6	0.9	2.6	1.1	0.2	-0.5	0.4	-1.6
Patch foraging water rate 24 sec	1.6	2.2	5.6	2.0	0.8	-0.4	0.7	-2.4
Patch foraging water rate 6 sec	0.2	0.3	0.7	0.4	0.0	-0.6	0.6	-0.9
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	2.7	1.6	1.2	0.7	-1.0	-1.1
Distance traveled before self-admin	2.2	2.3	5.1	1.0	1.4	1.7	-2.3	0.6
Distance traveled after self-admin	0.3	0.4	0.8	0.7	0.5	-0.1	0.5	-0.9
Extensor digitorum longus weight	0.4	1.5	4.1	0.7	-0.3	-1.3	1.1	-2.0
Bone: elastic displacement	1.6	1.8	2.6	1.4	1.4	1.6	-1.6	0.0
Bone: elastic work	8.3	10.7	15.0	3.1	3.7	3.9	-3.9	0.4
Bone: endosteal estimation	0.4	0.8	1.6	0.2	-0.3	-0.9	1.2	-1.3
Bone: endosteal perimeter	0.6	1.2	1.8	1.4	1.1	0.9	-1.2	-0.7
Epididymis fat weight	0.7	1.7	4.9	2.2	1.0	0.5	-0.5	-1.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.0	-0.5	-0.6	0.4	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	-0.2	-0.4	0.4	-0.0
Diff in mean of infusions in LGA sessions	0.3	0.4	0.7	-0.6	-0.4	0.0	0.8	0.7
Delay discount exponential model param	1.7	1.8	3.5	1.9	1.5	1.2	-1.0	-1.0
Extinction: sum of active levers before priming	1.0	1.0	2.1	-1.4	-1.0	-0.3	0.3	1.4
Active lever presses in extinction session 6	0.8	0.8	3.0	-0.5	-0.1	0.9	-0.1	1.7
Bone: final force	4.2	6.8	11.3	3.4	3.1	2.4	-2.1	-1.4
Bone: final moment	5.0	8.2	12.9	3.6	3.4	2.8	-2.6	-1.3
Food consumed during 24 hour testing period	0.4	0.5	1.0	0.8	0.6	0.5	-1.0	-0.4
Glucose	3.4	5.1	15.4	-2.6	-0.6	0.9	-1.4	3.9
Heart weight	0.3	0.5	0.9	1.0	0.9	0.8	-0.3	-0.2
Delay discount hyperbolic model param	1.7	1.8	3.4	1.8	1.5	1.2	-1.0	-0.9
Intermittent access intake day 1-15 change	1.0	1.0	2.0	0.7	1.2	0.8	-1.4	-0.5
Intermittent access intake escalation	0.7	0.6	1.2	0.7	1.0	0.5	-1.1	-0.6
Intermittent access intake escalation 2	2.3	2.3	3.8	1.2	1.8	1.9	-1.7	0.1
Intermitt. access day 1 inactive lever presses	1.0	1.0	2.1	0.8	1.3	1.5	-0.9	0.2
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.3	1.1	0.7	-0.1	-0.9	-0.9
Intermitt. access escalation Index	0.8	0.7	2.1	1.1	0.2	-0.4	0.0	-1.4
Intermittent access day 1 total infusions	0.3	0.3	0.7	0.8	0.6	0.0	0.2	-0.6
Intermittent access day 15 total infusions	0.5	0.6	1.0	1.0	0.9	-0.0	-0.5	-0.9
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.7	1.3	1.2	0.4	-0.7	-0.9
Intermittent access total infusions	0.4	0.5	0.9	0.9	0.7	-0.1	-0.2	-0.9
Intermittent access day 1 locomotion	0.3	0.3	0.9	0.8	0.4	-0.1	0.2	-0.9
Intermittent access day 15 total locomotion	0.4	0.4	0.7	0.8	0.9	0.7	0.1	-0.5
Intermittent access total locomotion	0.3	0.4	0.7	0.8	0.7	0.4	-0.3	-0.7
Intermittent access standard deviation	1.1	1.2	2.6	-0.7	0.1	0.9	-1.4	1.6
Left kidney weight	0.1	0.3	1.0	0.4	0.4	1.0	-0.1	0.5
Right kidney weight	0.0	0.1	0.5	0.0	-0.1	0.2	0.7	0.1
Cocaine induced anxiety	5.0	5.8	9.0	1.7	2.9	2.8	-3.0	0.7
Post-drug Anxiety	1.3	1.5	2.9	0.2	1.1	1.5	-1.7	1.0
Baseline Anxiety	5.6	5.9	10.8	-2.8	-3.3	-2.6	2.0	0.8
Tail length	3.7	11.3	21.8	4.7	3.8	1.7	-1.3	-4.0
Length with tail	1.8	6.7	11.3	3.4	3.1	2.7	-2.0	-1.3
Length without tail	1.0	2.1	6.5	-0.7	0.0	1.6	-0.9	2.5
Times rat made contact with spout	2.0	2.3	3.8	1.0	1.7	2.0	-1.8	0.8
Lifetime Intake	0.2	0.2	0.3	0.6	0.3	-0.3	-0.1	-0.6
Liver weight, left	0.5	0.8	2.4	-0.4	0.2	0.9	-0.6	1.6
Liver weight, right	1.4	2.4	4.4	2.1	1.8	1.4	-1.4	-0.6
Locomotor activity	0.6	1.0	1.5	-1.2	-1.1	-0.4	1.2	0.9
Locomotor testing distance	0.9	1.5	2.6	-1.1	-1.6	-0.9	1.6	0.7
Locomotor testing rearing	0.4	0.7	1.6	-0.6	-1.0	-0.8	1.2	0.2
Locomotion in novel chamber	0.4	0.5	0.9	-0.3	-1.0	-1.0	0.7	0.0
Locomotion in novel chamber post-restriction	2.2	2.6	3.6	1.8	1.9	1.4	-1.6	-1.2
Fecal boli incidents, locomotor time 1	0.4	0.4	0.8	-0.7	-0.9	-0.9	0.3	0.0
Change in fecal boli incidents, locomotor task	1.9	1.8	4.2	-1.8	-0.6	0.1	1.1	2.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.6	1.0	0.2	-0.7	0.6	-1.6
Bouts of movement, locomotor time 1	0.9	1.0	2.1	-1.5	-1.3	-0.5	0.6	0.9
Total resting periods, locomotor time 1	1.1	1.3	2.9	-1.7	-1.3	-0.2	0.4	1.2
Rest time, locomotor task time 1	0.3	0.4	0.8	-0.6	-0.1	0.5	-0.6	0.9
Distance moved, locomotor task time 1	0.4	0.4	1.0	1.0	0.5	-0.1	-0.1	-0.9
Vertical activity count, locomotor time 1	0.9	0.9	2.2	1.5	0.4	-0.3	-0.2	-1.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.1	-0.1	-0.3	0.3	-0.5
Bouts of movement, locomotor time 2	0.8	0.9	1.5	-1.2	-1.2	-1.0	0.7	0.2
Total resting periods, locomotor time 2	0.8	0.8	1.3	-0.9	-1.2	-1.1	0.8	-0.3
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1	0.0
Distance moved, locomotor task time 2	0.0	0.1	0.2	0.1	-0.0	-0.2	0.4	-0.2
Vertical activity count, locomotor time 2	0.4	0.5	1.0	0.5	-0.4	-0.7	0.6	-1.0
Light reinforcement 1	0.8	1.5	3.9	2.0	0.5	-0.3	-0.3	-1.8
Light reinforcement 2	1.4	1.9	5.3	2.3	1.1	0.5	-0.6	-1.5
Bone: marrow area	0.4	0.8	1.5	0.2	-0.3	-0.9	1.2	-1.2
Bone: maximum diameter	1.1	2.0	3.7	1.9	1.5	1.3	-1.3	-1.0
Bone: maximum force	4.1	7.1	12.2	3.5	3.3	2.3	-2.1	-1.7
Bone: maximum moment	4.9	8.5	13.7	3.7	3.5	2.7	-2.5	-1.6
Mean time between licks in bursts	1.3	1.8	2.4	-1.5	-1.5	-1.3	1.5	0.5
Mean num. licks in bursts	0.8	0.9	1.8	0.1	0.9	1.3	-1.1	0.9
Cd content in liver	1.3	1.4	2.3	-1.5	-1.4	-1.3	1.0	0.3
Co content in liver	0.2	0.2	0.6	-0.3	-0.6	-0.2	0.8	0.1
Cu content in liver	1.2	1.5	2.8	0.3	0.9	1.7	-1.5	1.2
Fe content in liver	0.8	1.0	1.8	-1.1	-1.3	-0.9	1.0	0.3
K content in liver	1.3	1.3	2.9	1.6	0.8	0.3	-0.2	-1.7
Mg content in liver	1.3	1.3	3.8	0.5	-0.4	-1.1	1.1	-1.9
Mn content in liver	0.2	0.2	0.3	0.5	0.5	0.5	-0.4	-0.1
Na content in liver	0.0	0.0	0.1	0.1	-0.2	0.1	-0.1	0.3
Rb content in liver	0.7	0.9	2.7	1.1	0.5	-0.1	0.1	-1.6
Se content in liver	0.2	0.2	0.4	0.7	0.5	0.2	-0.5	-0.6
Sr content in liver	1.7	1.6	3.5	-0.4	0.3	1.2	-1.7	1.9
Zn content in liver	0.1	0.1	0.3	-0.2	0.0	0.2	-0.6	0.2
Bone: minimum diameter	2.8	5.3	7.9	2.8	2.4	2.4	-2.5	-0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.3	0.3	0.3	-0.9	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.7	0.1	-0.2	-0.3	0.9	-0.5
Total zone transitions, hab. session 1	0.3	0.4	0.8	-0.6	-0.7	-0.9	0.6	-0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.9	0.4	-0.2	-0.5	-0.0	-1.0
Locomotion velocity, hab. session 1	0.2	0.3	1.0	0.5	-0.2	-0.5	-0.0	-1.0
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.1	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.4	-0.2	-0.1	-0.2	0.6	0.0
Total zone transitions, hab. session 2	1.4	1.8	3.1	-0.3	-1.0	-1.8	1.4	-1.6
Total locomotion distance, hab. session 2	1.4	1.8	5.6	0.9	-0.2	-1.2	1.0	-2.4
Locomotion velocity, hab. session 2	1.3	1.7	5.9	1.2	0.0	-1.0	0.7	-2.4
Novel to familiar place preference ratio	3.1	3.2	4.8	1.6	2.1	2.2	-2.0	0.3
Novelty place preference	3.2	3.2	4.8	1.6	2.1	2.2	-2.1	0.4
Time in novel zone, NPP test	2.4	2.5	3.5	1.4	1.9	1.9	-1.8	0.2
Total zone transitions, NPP test	2.1	3.0	5.1	-0.4	-1.5	-2.3	2.0	-1.8
Total locomotion distance, NPP test	1.9	2.6	6.2	0.5	-0.9	-1.8	1.5	-2.5
Locomotion velocity, NPP test	1.2	1.7	4.8	0.7	-0.6	-1.4	1.1	-2.2
Intraocular pressure	0.5	0.7	1.3	1.0	0.9	0.3	-0.1	-1.1
Delta distance traveled before/after self-admin	1.7	1.8	5.1	-0.4	-1.0	-1.5	2.2	-0.8
Delta ambulatory time before/after self-admin	2.5	2.7	6.8	-1.1	-1.5	-1.8	2.6	-0.5
Parametrial fat weight	1.4	2.8	4.7	2.2	1.9	1.4	-1.6	-1.0
Pavlov. Cond. lever latency	1.5	1.9	3.7	-0.8	-1.4	-1.9	1.2	-1.2
Pavlov. Cond. magazine entry latency	3.3	4.3	6.6	1.6	2.3	2.5	-2.6	0.9
Pavlov. Cond. change in total contacts	1.4	1.5	2.8	0.3	0.9	1.7	-1.2	1.5
Pavlov. Cond. index score	3.0	3.8	5.7	2.0	2.3	2.4	-2.1	0.3
Pavlov. Cond. latency score	2.6	3.3	5.5	1.6	2.1	2.3	-1.9	0.6
Pavlov. Cond. lever contacts	0.8	0.9	1.7	0.9	1.1	1.3	-0.9	0.5
Pavlov. Cond. magazine entry number	3.8	4.7	7.5	-1.3	-2.3	-2.7	2.7	-1.5
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.3	0.7	0.2	-0.5	-0.1	-1.5
Pavlov. Cond. lever-magazine prob. diff.	3.3	4.1	6.0	2.0	2.3	2.4	-2.2	0.4
Pavlov. Cond. response bias	3.1	3.8	6.0	1.3	2.1	2.4	-2.3	1.1
Pavlov. Cond. lever latency	0.6	0.7	2.3	-1.0	-0.4	0.4	-0.3	1.5
Pavlov. Cond. magazine entry latency	1.8	2.1	3.5	-1.2	-1.7	-1.9	1.6	-0.4
Pavlov. Cond. change in total contacts	0.5	0.7	1.2	-0.2	-0.8	-1.1	1.0	-0.7
Pavlov. Cond. index score	0.4	0.5	0.9	-0.1	-0.7	-1.0	0.7	-0.7
Pavlov. Cond. latency score	0.5	0.6	1.1	-0.0	-0.7	-1.0	0.8	-0.9
Pavlov. Cond. lever contacts	0.8	1.1	3.3	1.3	0.5	-0.4	0.4	-1.8
Pavlov. Cond. magazine entry number	1.4	1.7	3.0	0.9	1.6	1.7	-1.4	0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.5	2.4	1.5	1.6	0.8	-0.6	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-0.3	-0.8	-1.1	0.8	-0.7
Pavlov. Cond. response bias	0.4	0.6	1.4	0.4	-0.1	-0.8	0.8	-1.2
Time in closed arm before self-admin	0.5	0.6	1.1	-0.3	0.3	1.0	-0.8	1.0
Time in closed arm after self-admin	1.1	1.1	2.6	-0.9	-0.0	1.1	-1.0	1.6
Time in open arm before self-admin	0.5	0.6	1.6	-0.2	-0.7	-0.8	1.3	-0.3
Time in open arm after self-admin	0.7	0.7	1.7	-0.2	-0.8	-1.2	1.3	-0.3
Bone: periosteal estimation	1.4	2.8	5.5	2.4	1.9	1.3	-1.1	-1.5
Bone: periosteal perimeter	3.4	5.6	8.2	2.4	2.6	2.7	-2.9	-0.1
Bone: post-yield work	0.3	0.4	0.9	0.0	-0.3	-0.8	0.6	-0.9
Progressive ratio test 1 active lever presses	0.8	0.8	1.9	1.4	1.0	0.3	-0.1	-1.1
Progressive ratio test 1 breakpoint	1.1	1.2	2.6	1.6	1.2	0.5	-0.5	-1.2
Progressive ratio test 1 inactive lever presses	1.6	1.8	3.8	2.0	1.5	0.6	-0.5	-1.4
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.8	0.7	0.4	-0.4	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	1.0	0.7	0.2	-0.3	-1.0
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.6	0.6	0.7	0.6	-0.4	-0.2
Incentive Sensitization - Responses	0.3	0.3	0.5	0.4	0.5	0.5	-0.7	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	0.3	0.5	0.6	-0.7	-0.3
Sum of active levers in priming session hrs 5-6	1.2	1.2	3.4	0.8	1.2	1.9	-0.3	0.5
Progressive ratio	0.3	0.3	0.6	-0.8	-0.7	-0.4	0.1	0.5
Food seeking constrained by brief footshock	0.2	0.2	0.6	-0.4	-0.0	0.5	-0.5	0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.5	0.4	0.1	-0.1	-0.5
Retroperitoneal fat weight	3.2	10.6	21.1	4.6	3.3	2.5	-2.7	-2.6
Reaction time number correct	3.4	4.9	8.9	0.8	-1.1	-2.5	3.0	-2.8
Reaction time mean minus median	0.2	0.3	1.0	-0.4	-0.0	0.6	-0.3	1.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	0.3
Reaction time num false alarms	0.1	0.2	0.4	-0.6	-0.6	-0.2	-0.3	0.3
Reaction time num false alarms AUC	0.4	0.5	1.1	-1.0	-1.0	-0.6	0.1	0.3
Reaction time trials correct on left	3.4	4.9	8.9	0.8	-1.1	-2.5	3.0	-2.8
Reaction time trials on left	3.6	5.1	9.2	0.8	-1.1	-2.5	3.0	-2.8
Reaction time mean	0.2	0.2	0.6	0.8	0.5	0.2	-0.1	-0.4
Reaction time mean AUC	0.3	0.3	0.8	0.9	0.2	-0.2	0.4	-0.8
Median of all reaction times	0.2	0.3	0.8	0.9	0.5	-0.1	0.1	-0.8
Reaction time omissions	0.1	0.2	0.4	0.4	-0.3	-0.2	0.4	-0.6
Reaction time false alarm rate	1.0	1.4	2.9	-1.3	-0.4	0.6	-1.4	1.7
Reaction time premature initiation rate	0.9	1.2	2.7	-1.6	-1.2	-0.7	0.7	0.9
Reaction time premature initiations	1.7	2.4	4.5	-1.0	-1.6	-1.9	2.1	-0.7
Std. dev. reaction times	0.2	0.3	0.4	-0.5	-0.7	-0.6	0.7	0.3
Reaction time trials completed	3.6	5.1	9.2	0.8	-1.1	-2.5	3.0	-2.8
Reaction time trials AUC	3.5	5.0	9.0	0.8	-1.0	-2.5	3.0	-2.8
Run reversals in cocaine runway, females	1.7	1.6	3.6	-0.6	-1.2	-1.6	1.9	-0.2
Run reversals in cocaine runway, males	2.0	1.9	3.6	0.9	1.5	1.9	-1.6	0.5
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.6	-0.5	-0.8	0.5	-0.2
Latency to leave start box in cocaine runway, F	1.0	1.1	2.1	-0.4	-1.0	-1.4	1.5	-0.8
Latency to leave start box in cocaine runway, M	0.4	0.4	1.3	-0.1	0.6	0.4	-1.1	-0.0
Std. dev. time between licks in bursts	1.9	2.3	6.5	1.2	-0.4	-1.5	1.2	-2.5
Total sessions with >9 infusions	0.4	0.4	1.3	-0.5	-0.6	-1.1	0.3	-0.0
Short access day 1 total inactive lever presses	0.9	1.0	2.5	0.2	-0.7	-1.1	1.6	-0.9
Short access day 10 total inactive lever presses	2.4	2.7	4.6	1.8	2.1	1.5	-1.7	-0.7
Short access day 1 total infusions	1.2	1.3	1.9	-1.3	-1.4	-1.1	1.0	0.8
Short access day 10 total infusions	0.5	0.5	1.1	0.8	1.0	0.5	-0.6	-0.5
Short access total infusions	0.0	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.1
Short access day 1 locomotion	0.3	0.3	0.6	-0.8	-0.4	-0.1	0.3	0.8
Short access day 10 total locomotion	0.3	0.3	0.9	-0.5	0.1	0.6	-0.3	0.9
Short access total locomotion	0.2	0.3	0.7	-0.9	-0.3	-0.2	-0.2	0.6
One hour access (0.3 mA shock)	1.1	1.3	2.5	1.6	1.2	0.2	-0.8	-1.4
Compulsive drug intake	0.4	0.5	0.8	0.9	0.5	0.5	-0.8	-0.6
One hour access (shock baseline)	0.3	0.4	0.7	0.6	0.2	-0.8	0.1	-0.9
Social response proportion	0.5	0.5	0.9	-0.4	-0.8	-0.9	1.0	-0.1
Social responses	0.2	0.2	0.5	-0.2	-0.7	-0.7	0.2	-0.1
Social time	0.1	0.1	0.3	-0.1	-0.6	-0.5	0.1	-0.1
Soleus weight	0.9	2.8	5.4	2.3	1.8	1.0	-1.4	-1.5
Bone: stiffness	0.5	0.8	1.6	1.3	1.1	0.5	-0.1	-1.0
Tibialis anterior weight	0.1	0.4	1.4	0.4	-0.0	-0.7	0.5	-1.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	0.3	0.2	-0.4	0.9	-0.5
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.7	-1.5	-1.6	-1.1	0.6	0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.1	0.6	0.4	-0.1	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.4	-0.6	-0.6	-0.1	0.6	0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	-0.4	-0.9	-0.7	0.0	-0.2
Delta time to tail flick, test, before/after SA	0.5	0.5	1.2	-0.7	-0.7	0.1	0.6	1.1
Tibia length	8.0	22.5	32.3	5.2	5.7	5.1	-5.1	-0.8
Ambulatory time before self-admin	2.6	2.7	4.0	1.6	1.8	1.9	-2.0	0.2
Ambulatory time after self-admin	0.1	0.1	0.2	0.5	0.4	0.1	0.2	-0.5
Bone: tissue strength	1.0	1.0	2.1	1.5	0.8	0.2	-0.3	-1.5
Total heroin consumption	0.8	0.9	2.5	-0.1	0.4	1.0	-0.9	1.6
Bone: trabecular number	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.2
Bone: trabecular spacing	1.5	1.9	5.2	0.8	-0.5	-1.4	1.2	-2.3
Bone: trabecular thickness	1.9	2.3	3.6	0.4	1.4	1.9	-1.9	1.4
Bone: trabecular tissue density	0.6	0.9	1.5	-1.2	-1.0	-0.8	0.9	0.6
Water consumed over 24 hours	0.4	0.5	1.4	-0.2	0.3	0.7	-0.5	1.2
Number of responses in last shaping day	0.5	0.6	1.5	1.2	0.5	0.4	-0.7	-0.6