Hub : Genes

Fra10ac1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Fra10ac1	0.04	0.02	5.9e-04	0.03	0.02	0.02	0.02	3.8e-04	2.9e-03	1.8e-03	1.9e-03
2	LHb	mRNA stability	Fra10ac1	0.32	0.15	6.7e-03	0.06	0.04	0.02	0.06	1.9e-02	3.3e-02	1.3e-01	1.7e-02
3	Adipose	intron excision ratio	chr1_245381862_245382882	0.04	0.02	3.2e-04	0.02	0.02	0.01	0.01	3.5e-03	5.2e-03	1.5e-02	1.0e-02
4	Adipose	gene expression	Fra10ac1	0.04	0.02	2.5e-03	0.01	0.01	0	0.01	1.1e-02	7.0e-03	2.4e-01	6.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	4.9	8.4	14.8	-3.6	3.8	2.4	-0.6
Area under the delay curve	1.1	1.2	2.2	0.7	-0.8	-1.3	1.5
BMI with tail	0.0	0.2	0.4	0.5	-0.3	0.0	0.6
BMI without tail	0.0	0.1	0.3	0.6	-0.4	0.2	-0.1
Body weight	0.6	2.7	3.4	-1.8	1.8	1.3	-1.6
Weight adjusted by age	0.8	1.1	2.7	0.4	-0.2	-1.3	1.7
Bone surface	4.7	8.6	14.6	-3.8	3.8	2.0	-1.2
Bone volume	4.9	8.7	13.7	-3.7	3.6	2.4	-1.5
Breakpoint value in progressive ratio session	0.2	0.3	0.6	0.5	-0.8	-0.5	0.1
Number of licking bursts	1.5	2.5	3.1	1.4	-1.4	-1.7	1.8
Context. condit. distance diff. score	1.0	1.2	2.5	-1.0	0.4	1.6	-1.1
Locomotion velocity, session 1	2.2	2.3	2.4	1.5	-1.5	-1.6	1.6
Locomotion distance, session 1	0.6	0.7	1.1	0.7	-0.7	-0.9	1.0
Locomotion velocity, session 2	0.2	0.3	0.6	-0.1	-0.8	0.7	-0.0
Locomotion distance, session 2	0.2	0.2	0.7	0.5	-0.8	-0.0	0.1
Locomotion velocity, session 3	0.3	0.3	0.7	-0.4	0.0	0.6	-0.8
Locomotion distance, session 3	2.0	2.2	5.2	-1.0	0.3	1.6	-2.3
Stereotopy head waving bouts, day 3	0.1	0.2	0.6	0.2	-0.1	0.1	0.7
Stereotopy head waving duration, day 3	0.5	0.5	2.1	0.1	0.1	-0.2	1.4
Locomotion velocity, session 7	1.7	1.9	3.3	-1.1	0.5	1.7	-1.8
Locomotion distance, session 7	2.2	2.8	5.0	-1.5	0.7	1.9	-2.2
Stereotopy head waving bouts, day 7	0.3	0.4	1.4	0.2	0.2	-0.0	1.2
Stereotopy head waving duration, day 7	0.4	0.5	1.1	-0.4	1.0	0.3	0.9
Locomotion velocity, session 8	0.3	0.3	0.6	-0.8	0.7	0.5	-0.1
Locomotion distance, session 8	0.2	0.3	0.6	-0.0	-0.7	0.8	-0.2
Degree of sensitization distance	0.2	0.2	0.3	0.2	-0.5	-0.2	0.5
Degree of sensitization stereotypy	0.4	0.4	1.0	-0.1	0.8	-0.1	1.0
Conditioned locomotion	0.1	0.1	0.2	-0.2	0.5	-0.3	-0.5
Cocaine response after cond. corrected	0.0	0.0	0.1	0.0	0.1	-0.4	0.2
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.1	0.1	-0.3	0.0
Cocaine response before conditioning	0.0	0.0	0.1	0.2	-0.2	-0.1	0.3
Saline control response	2.6	3.5	5.5	1.9	-1.6	-2.3	1.5
Bone: connectivity density	4.2	6.6	10.1	-3.1	3.2	2.4	-0.7
Bone: cortical apparent density	0.9	1.3	2.9	1.0	-0.9	-0.5	1.7
Bone: cortical area	4.1	6.3	8.4	-2.9	2.8	2.0	-2.2
Bone: cortical porosity	0.3	0.3	0.9	0.1	-0.4	1.0	0.3
Bone: cortical porosity	0.7	0.7	2.3	-0.6	0.2	1.5	-0.5
Bone: cortical thickness	0.1	0.2	0.5	-0.5	0.7	-0.1	-0.3
Bone: cortical thickness	0.4	0.5	1.0	0.6	-0.3	-0.6	1.0
Bone: cortical tissue density	1.1	1.5	3.4	1.1	-1.0	-0.6	1.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.2	-0.5	0.0	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	-0.2	-0.0	-0.5
Condit. Reinf. active responses	0.2	0.2	0.7	0.2	-0.3	-0.0	-0.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.1	-0.3	-0.0
Incentive salience index mean	0.7	0.9	1.7	0.9	-1.3	-0.7	-0.6
Condit. Reinf. lever presses	2.3	3.3	5.2	2.1	-2.3	-1.8	0.4
Condit. Reinf. active minus inactive responses	1.1	1.4	2.1	-1.5	0.9	1.3	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.7	0.6	0.5	-0.0
Condit. Reinf. active responses	0.7	1.0	1.4	-1.2	1.1	0.6	-0.9
Condit. Reinf. inactive responses	0.1	0.2	0.4	-0.2	0.4	-0.2	-0.6
Condit. Reinf. lever presses	0.2	0.2	0.6	0.0	0.3	-0.8	0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.8	0.7	0.1	-0.5
Conditioned reinforcement - actives	1.5	2.6	4.4	-1.9	2.1	1.5	-0.6
Conditioned reinforcement - inactives	2.4	3.5	5.6	-2.4	1.6	2.1	-1.0
Conditioned locomotion	1.5	1.9	3.5	-1.7	1.9	1.0	-0.4
Patch foraging indifference point 0 sec	0.1	0.2	0.3	-0.2	0.5	-0.5	-0.3
Patch foraging indifference point AUC	1.1	1.6	2.8	1.1	-1.0	-1.7	1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.0	-0.5	0.1	0.7
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	0.1	0.0	-0.8	0.9
Delay disc. indifference point, 2s delay	0.6	0.7	2.3	0.4	-0.2	-0.6	1.5
Delay disc. indifference point, 24s delay	0.9	1.0	2.0	1.1	-1.4	-0.8	0.7
Delay disc. indifference point, 4s delay	1.1	1.2	2.3	0.8	-0.9	-1.1	1.5
Delay disc. indifference point, 8s delay	3.1	3.6	6.1	1.6	-1.4	-2.5	2.0
Indifference point function ln k	2.0	3.6	6.1	-1.7	1.4	2.5	-1.9
Indifference point function log k	2.0	3.6	6.1	-1.7	1.4	2.5	-1.9
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.4	0.7	-0.4	-0.3
Patch foraging total patch changes 12 sec	2.2	2.8	5.7	1.4	-0.7	-2.4	1.8
Patch foraging total patch changes 18 sec	0.9	1.3	1.9	1.1	-0.7	-1.3	1.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	-0.2	-0.1	-0.4	-0.5
Patch foraging total patch changes 6 sec	0.5	0.8	2.5	0.5	0.0	-1.6	0.7
Patch foraging time to switch 0 sec	1.1	2.3	2.9	1.5	-1.2	-1.7	1.6
Patch foraging water rate 0 sec	1.0	2.1	3.5	-1.2	0.7	1.9	-1.7
Patch foraging water rate 12 sec	1.1	2.2	3.4	-1.3	1.0	1.7	-1.8
Patch foraging water rate 18 sec	1.4	2.2	3.9	-1.1	0.5	1.9	-2.0
Patch foraging water rate 24 sec	0.9	1.3	1.6	-1.1	0.8	1.3	-1.2
Patch foraging water rate 6 sec	0.3	0.4	0.7	-0.6	0.7	0.8	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	0.2	-0.4	0.0	-0.7
Distance traveled before self-admin	0.4	0.5	0.9	0.7	-0.9	0.5	-0.7
Distance traveled after self-admin	0.3	0.4	1.2	-0.4	0.3	1.1	0.2
Extensor digitorum longus weight	0.2	0.7	1.6	-0.3	-0.4	0.9	-1.3
Bone: elastic displacement	1.5	1.7	2.4	1.5	-1.3	-0.7	1.4
Bone: elastic work	0.3	0.4	0.7	0.5	-0.7	0.1	0.9
Bone: endosteal estimation	6.7	14.7	20.4	-4.5	4.2	3.6	-2.8
Bone: endosteal perimeter	6.4	13.7	20.3	-4.5	4.4	3.1	-2.2
Epididymis fat weight	0.3	0.9	1.3	-1.0	1.0	1.1	-0.5
Delta time in closed arm before/after self-admin	0.3	0.3	1.0	-0.5	-0.0	0.1	-1.0
Delta time in open arm before/after self-admin	0.3	0.3	0.9	0.5	-0.4	0.2	0.9
Diff in mean of infusions in LGA sessions	0.6	0.7	1.5	-0.6	0.5	1.2	-1.0
Delay discount exponential model param	1.0	1.1	2.0	-0.6	0.7	1.2	-1.4
Extinction: sum of active levers before priming	1.0	1.1	3.1	-0.6	-0.2	1.0	-1.8
Active lever presses in extinction session 6	0.6	0.6	1.2	-1.0	0.1	1.1	0.0
Bone: final force	2.0	3.2	4.6	-2.2	2.0	1.4	-1.4
Bone: final moment	2.2	3.5	5.0	-2.2	2.2	1.5	-1.5
Food consumed during 24 hour testing period	0.3	0.5	0.9	-0.7	0.6	0.4	-0.9
Glucose	0.5	0.8	1.6	-0.4	0.3	1.1	-1.3
Heart weight	0.5	0.8	1.3	-0.6	1.0	0.7	-1.1
Delay discount hyperbolic model param	0.9	1.0	1.9	-0.6	0.7	1.1	-1.4
Intermittent access intake day 1-15 change	3.4	7.0	11.7	-3.2	3.4	2.0	-1.5
Intermittent access intake escalation	3.4	6.9	11.0	-3.1	3.3	2.2	-1.6
Intermittent access intake escalation 2	4.4	5.0	6.6	-2.6	2.6	2.1	-1.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.3	-0.3	-0.4	0.5
Intermitt. access day 15 inactive lever presses	1.4	2.9	4.9	-2.2	2.1	1.5	-0.5
Intermitt. access escalation Index	0.2	0.3	0.7	0.8	-0.3	-0.5	0.2
Intermittent access day 1 total infusions	0.9	1.5	2.8	-1.5	1.0	1.7	-0.3
Intermittent access day 15 total infusions	6.1	9.1	12.3	-3.5	3.5	3.0	-1.8
Intermittent access terminal intake (last 3 days)	5.3	6.9	9.0	-3.0	3.0	2.8	-1.3
Intermittent access total infusions	3.3	3.8	5.4	-2.2	2.1	2.3	-0.9
Intermittent access day 1 locomotion	0.7	0.9	1.6	-1.0	0.9	1.3	-0.4
Intermittent access day 15 total locomotion	1.1	2.0	3.9	-1.8	2.0	0.9	0.1
Intermittent access total locomotion	1.2	1.4	2.1	-1.5	1.2	1.4	0.1
Intermittent access standard deviation	4.5	9.4	12.4	-3.5	3.4	2.9	-2.2
Left kidney weight	0.4	1.7	3.3	-1.5	1.8	0.5	-1.0
Right kidney weight	0.1	0.5	1.0	-0.5	0.9	-0.2	-1.0
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	0.4	0.0	0.1
Post-drug Anxiety	0.4	0.4	0.9	-0.1	1.0	-0.8	0.3
Baseline Anxiety	0.2	0.2	0.6	-0.3	0.8	-0.3	-0.4
Tail length	0.7	2.6	4.0	-1.6	1.4	1.3	-2.0
Length with tail	1.4	5.9	8.9	-2.9	3.0	1.5	-2.0
Length without tail	1.5	4.9	7.7	-2.7	2.8	1.6	-1.4
Times rat made contact with spout	0.2	0.3	0.4	0.5	-0.7	-0.3	0.6
Lifetime Intake	2.7	3.2	4.6	-2.1	1.9	2.1	-0.7
Liver weight, left	0.4	0.7	1.3	-0.8	1.1	0.2	-0.9
Liver weight, right	1.2	2.1	3.5	-1.6	1.9	1.2	-1.0
Locomotor activity	0.1	0.1	0.3	0.3	-0.6	0.1	-0.4
Locomotor testing distance	0.0	0.1	0.2	0.0	-0.4	-0.2	-0.3
Locomotor testing rearing	0.2	0.3	0.7	-0.5	-0.2	0.5	-0.8
Locomotion in novel chamber	0.9	1.1	2.5	-1.1	0.8	1.6	-0.4
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.5	0.4	0.1	0.0
Fecal boli incidents, locomotor time 1	0.2	0.3	0.7	-0.1	-0.6	0.9	-0.3
Change in fecal boli incidents, locomotor task	0.5	0.5	1.3	0.5	-0.4	-1.1	0.2
Time >=10cm from walls, locomotor time 1	2.3	2.5	5.9	-1.4	0.9	1.1	-2.4
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.3	0.4	-0.6	0.9
Total resting periods, locomotor time 1	0.4	0.4	1.0	0.4	0.2	-0.7	1.0
Rest time, locomotor task time 1	0.8	1.0	2.1	0.8	-0.6	-1.0	1.5
Distance moved, locomotor task time 1	0.6	0.9	3.1	-0.5	-0.3	0.6	-1.7
Vertical activity count, locomotor time 1	0.4	1.0	1.5	-1.0	1.0	0.6	-1.2
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.2	-0.7	0.0	0.2	-1.1
Bouts of movement, locomotor time 2	2.0	3.2	3.8	2.0	-1.8	-1.6	1.9
Total resting periods, locomotor time 2	1.8	3.2	3.9	2.0	-1.8	-1.6	1.8
Rest time, locomotor task time 2	0.9	1.1	1.6	0.9	-0.6	-1.2	1.3
Distance moved, locomotor task time 2	1.4	1.7	4.3	-1.0	-0.0	1.3	-2.1
Vertical activity count, locomotor time 2	0.6	0.8	1.4	-1.1	0.5	0.8	-1.2
Light reinforcement 1	0.2	0.5	1.7	0.2	0.1	-0.6	1.3
Light reinforcement 2	2.5	3.9	6.9	1.9	-1.5	-1.6	2.6
Bone: marrow area	6.8	14.9	20.8	-4.6	4.2	3.7	-2.7
Bone: maximum diameter	8.5	15.9	23.5	-4.8	4.8	3.4	-2.4
Bone: maximum force	3.5	6.2	9.4	-3.1	3.0	2.2	-1.2
Bone: maximum moment	3.8	6.7	10.0	-3.1	3.2	2.3	-1.3
Mean time between licks in bursts	0.1	0.2	0.4	0.3	-0.2	-0.5	-0.6
Mean num. licks in bursts	1.2	1.9	2.9	-1.2	1.0	1.7	-1.5
Cd content in liver	0.3	0.3	0.6	0.8	-0.4	-0.5	0.4
Co content in liver	0.1	0.2	0.4	0.5	-0.1	-0.6	-0.2
Cu content in liver	3.1	3.7	7.3	1.2	-0.2	-2.4	2.7
Fe content in liver	1.7	2.1	2.9	1.6	-1.0	-1.7	1.3
K content in liver	1.9	1.8	3.8	1.4	-2.0	-1.0	0.7
Mg content in liver	1.5	1.5	2.9	1.3	-1.7	-0.9	0.7
Mn content in liver	4.3	4.8	8.1	2.2	-1.7	-1.9	2.8
Na content in liver	3.1	3.4	5.2	2.1	-2.3	-1.6	1.1
Rb content in liver	0.7	0.9	1.1	-1.0	1.0	0.8	-0.8
Se content in liver	21.0	24.8	29.5	5.4	-4.9	-5.4	4.1
Sr content in liver	0.1	0.1	0.2	0.1	-0.0	-0.2	0.4
Zn content in liver	4.3	4.8	8.5	2.3	-2.9	-2.0	1.1
Bone: minimum diameter	10.9	20.0	25.0	-5.0	4.6	4.4	-3.8
Time in familiar zone, hab. session 1	0.8	0.7	1.5	-0.9	1.2	0.4	0.7
Time in novel zone, hab. session 1	0.6	0.6	1.5	0.8	-1.2	-0.5	-0.0
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.0	-0.1	-0.5	0.4
Total locomotion distance, hab. session 1	1.6	2.3	2.8	1.6	-1.7	-1.6	1.1
Locomotion velocity, hab. session 1	2.6	3.7	4.7	2.1	-2.1	-2.2	1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.1	0.0	-0.4	0.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.1	0.1	0.3	0.0
Total zone transitions, hab. session 2	0.3	0.4	0.9	0.5	-0.4	-0.9	0.4
Total locomotion distance, hab. session 2	0.6	0.8	1.1	1.1	-0.9	-1.1	0.4
Locomotion velocity, hab. session 2	1.0	1.3	1.8	1.3	-1.2	-1.4	0.7
Novel to familiar place preference ratio	1.3	1.5	3.8	-1.2	0.8	1.9	0.1
Novelty place preference	1.5	1.6	3.9	-1.3	0.9	2.0	0.2
Time in novel zone, NPP test	1.5	1.6	3.9	-1.4	0.8	2.0	0.0
Total zone transitions, NPP test	0.6	0.9	1.8	1.0	-1.4	-0.8	-0.1
Total locomotion distance, NPP test	1.9	2.6	3.5	1.9	-1.9	-1.7	0.8
Locomotion velocity, NPP test	2.0	2.9	4.3	2.0	-2.1	-1.6	0.6
Intraocular pressure	0.3	0.4	0.8	-0.3	0.9	0.1	0.9
Delta distance traveled before/after self-admin	1.7	1.8	3.0	-1.6	1.7	1.2	0.2
Delta ambulatory time before/after self-admin	1.8	2.2	3.4	-1.8	1.7	1.5	0.0
Parametrial fat weight	0.4	0.9	1.4	1.2	-1.2	-0.6	-0.5
Pavlov. Cond. lever latency	0.7	0.9	2.4	-0.7	1.5	0.2	0.8
Pavlov. Cond. magazine entry latency	0.5	0.6	1.8	0.3	-0.8	0.0	-1.4
Pavlov. Cond. change in total contacts	0.6	0.6	2.1	-0.1	-0.3	0.6	-1.4
Pavlov. Cond. index score	0.5	0.6	1.2	0.4	-1.1	-0.1	-1.0
Pavlov. Cond. latency score	0.6	0.7	1.7	0.5	-1.3	-0.2	-1.0
Pavlov. Cond. lever contacts	0.8	0.9	2.3	0.9	-1.5	-0.5	-0.5
Pavlov. Cond. magazine entry number	0.5	0.6	1.8	0.4	-0.0	-0.6	1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.6	-0.0	0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	0.6	-1.2	-0.1	-0.9
Pavlov. Cond. response bias	0.4	0.5	1.6	0.0	-0.6	0.3	-1.3
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.1	-0.6	0.9	-0.2
Pavlov. Cond. magazine entry latency	0.3	0.3	1.1	0.3	-0.4	0.1	-1.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	0.3	-0.4	-1.0	-0.3
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	0.3	-0.4	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.3	0.5	-0.2	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	1.2	0.1	0.4	-1.1	0.3
Pavlov. Cond. magazine entry number	0.6	0.8	1.0	-0.9	1.0	1.0	0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	-0.6	0.4	1.0	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.5
Pavlov. Cond. response bias	0.2	0.2	0.9	0.2	-0.0	-0.9	-0.2
Time in closed arm before self-admin	0.3	0.4	0.7	0.7	-0.8	0.8	0.2
Time in closed arm after self-admin	1.0	1.1	3.3	0.9	-1.8	-0.4	-0.1
Time in open arm before self-admin	0.3	0.3	0.9	-0.4	0.2	-0.9	0.2
Time in open arm after self-admin	0.5	0.6	1.0	-0.5	0.9	-0.5	1.0
Bone: periosteal estimation	7.0	14.8	21.3	-4.6	4.5	3.3	-2.6
Bone: periosteal perimeter	5.2	8.9	12.4	-3.5	3.5	2.6	-2.1
Bone: post-yield work	5.0	7.4	11.2	-3.3	3.2	2.4	-1.5
Progressive ratio test 1 active lever presses	1.5	1.8	3.0	-1.7	1.7	1.2	0.2
Progressive ratio test 1 breakpoint	1.2	1.5	2.6	-1.5	1.6	1.0	0.2
Progressive ratio test 1 inactive lever presses	1.2	1.7	2.6	-1.6	1.3	1.6	-0.4
Progressive ratio test 2 active lever presses	5.8	6.8	11.6	-3.4	3.2	2.3	-0.7
Progressive ratio test 2 breakpoint	6.2	7.1	11.9	-3.5	3.3	2.3	-0.7
Progressive ratio test 2 inactive lever presses	1.7	2.7	4.1	-2.0	2.0	1.7	0.1
Incentive Sensitization - Responses	4.4	6.2	9.0	-3.0	3.0	2.4	-1.1
Incentive Sensitization - Breakpoint	5.0	6.5	9.3	-3.1	3.0	2.4	-1.2
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.5	-0.0	-0.3	-0.7	0.1
Progressive ratio	0.3	0.5	1.0	1.0	-0.8	-0.6	-0.3
Food seeking constrained by brief footshock	2.2	2.7	3.2	-1.6	1.5	1.6	-1.8
Seeking ratio, punishment vs. effort	0.8	1.2	2.4	-1.5	1.0	0.9	-0.9
Retroperitoneal fat weight	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Reaction time number correct	0.4	0.7	1.2	-1.0	1.1	0.7	-0.3
Reaction time mean minus median	1.3	3.2	4.1	-1.7	1.8	1.6	-2.0
Reaction time mean minus median AUC	0.6	1.5	2.2	-1.2	1.3	0.8	-1.5
Reaction time num false alarms	0.1	0.1	0.5	-0.1	-0.0	-0.1	-0.7
Reaction time num false alarms AUC	0.2	0.3	1.2	-0.1	-0.1	0.0	-1.1
Reaction time trials correct on left	0.4	0.7	1.2	-1.0	1.1	0.7	-0.3
Reaction time trials on left	0.4	0.7	1.1	-1.0	1.1	0.7	-0.4
Reaction time mean	0.4	0.7	2.0	0.3	-0.8	0.1	-1.4
Reaction time mean AUC	0.4	0.6	1.2	0.6	-1.0	-0.1	-1.1
Median of all reaction times	0.8	1.1	2.4	1.0	-1.5	-0.3	-1.0
Reaction time omissions	1.1	1.7	5.3	-0.5	-0.0	1.1	-2.3
Reaction time false alarm rate	0.2	0.2	0.5	0.3	-0.4	-0.3	-0.7
Reaction time premature initiation rate	0.3	0.4	1.0	-0.4	0.6	-0.0	-1.0
Reaction time premature initiations	0.7	1.3	2.2	-1.1	1.5	0.4	-1.2
Std. dev. reaction times	1.3	2.3	5.6	-1.2	1.1	1.0	-2.4
Reaction time trials completed	0.4	0.7	1.1	-1.0	1.1	0.7	-0.4
Reaction time trials AUC	0.2	0.4	0.7	-0.8	0.8	0.5	-0.3
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.3	-0.3	-0.9	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.9	1.4	-0.4	-1.1	0.7
Latency to leave start box in cocaine runway	0.9	1.0	2.0	-0.9	0.4	1.1	-1.4
Latency to leave start box in cocaine runway, F	1.1	1.3	2.7	-0.7	0.3	1.6	-1.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.6	0.3	-0.3	-0.5
Std. dev. time between licks in bursts	1.1	1.5	2.2	1.3	-1.0	-1.5	1.1
Total sessions with >9 infusions	0.2	0.2	0.8	0.1	0.2	-0.1	0.9
Short access day 1 total inactive lever presses	0.7	1.0	1.4	-0.8	0.7	1.2	1.2
Short access day 10 total inactive lever presses	0.2	0.5	0.9	0.8	-0.9	-0.6	0.0
Short access day 1 total infusions	0.3	0.4	1.6	-0.1	0.2	-0.2	1.3
Short access day 10 total infusions	0.1	0.1	0.2	0.2	-0.0	0.1	0.5
Short access total infusions	0.5	0.7	1.2	-0.8	0.9	1.1	0.3
Short access day 1 locomotion	0.6	0.7	2.3	0.3	-0.5	-0.4	1.5
Short access day 10 total locomotion	0.3	0.6	1.0	1.0	-1.0	-0.3	0.6
Short access total locomotion	0.8	0.9	1.6	1.0	-1.0	-0.5	1.3
One hour access (0.3 mA shock)	10.8	12.4	18.9	-4.2	4.3	3.3	-1.5
Compulsive drug intake	0.4	0.4	0.8	-0.3	0.2	0.9	-0.9
One hour access (shock baseline)	2.8	4.4	7.2	-2.6	2.7	1.7	-0.8
Social response proportion	0.7	0.8	1.1	-1.0	1.0	1.0	0.1
Social responses	1.1	1.4	2.7	-1.5	1.6	0.9	0.1
Social time	0.4	0.6	0.8	0.9	-0.9	-0.7	0.4
Soleus weight	1.4	4.2	6.9	-2.6	2.0	1.9	-1.6
Bone: stiffness	3.3	5.4	7.2	-2.7	2.5	2.4	-1.6
Tibialis anterior weight	0.2	0.6	1.4	-0.6	-0.4	0.8	-1.2
Time to tail flick, vehicle, before self-admin	2.6	2.7	6.1	1.6	-0.7	-1.3	2.5
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.0	0.3	-1.0	0.1	-0.8
Time to tail flick, test, before self-admin	1.5	1.6	3.2	-1.3	0.6	1.8	-1.0
Time to tail flick, test, after self-admin	1.2	1.2	2.1	0.5	-1.1	-1.5	1.2
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	4.5	-1.1	-0.0	1.0	-2.1
Delta time to tail flick, test, before/after SA	1.5	1.6	2.9	1.0	-0.9	-1.7	1.3
Tibia length	0.2	0.6	1.1	-0.9	1.1	-0.2	-0.7
Ambulatory time before self-admin	0.5	0.7	1.6	1.0	-1.3	0.1	-0.4
Ambulatory time after self-admin	0.6	0.8	2.6	-0.6	0.3	1.6	0.0
Bone: tissue strength	0.5	0.5	0.8	-0.7	0.5	0.6	-0.9
Total heroin consumption	0.1	0.1	0.1	-0.3	0.2	0.2	-0.3
Bone: trabecular number	4.5	7.4	12.6	-3.2	3.5	2.5	-0.6
Bone: trabecular spacing	1.1	1.4	2.3	1.5	-1.5	-1.1	-0.3
Bone: trabecular thickness	3.7	4.6	6.8	-2.6	2.4	2.0	-1.3
Bone: trabecular tissue density	0.4	0.6	0.9	-0.9	0.9	0.9	-0.1
Water consumed over 24 hours	0.2	0.2	0.6	0.0	-0.6	0.8	-0.2
Number of responses in last shaping day	1.1	1.2	2.4	-0.3	1.4	-0.7	1.5