Hub : Genes

Fosb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC mRNA stability Fosb 0.16 0.14 3.0e-03 0.08 0.12 0.12 0.11 5.2e-03 9.2e-04 7.3e-04 1.2e-03
2 PL isoform ratio XM_039101873.2 0.05 0.12 1.5e-03 0.02 0.02 0.02 0.02 2.0e-03 5.7e-03 4.1e-03 2.8e-03
3 PL isoform ratio NM_001256509.1 0.05 0.12 3.8e-03 0.02 0.01 0.01 0.01 5.7e-03 1.4e-02 9.7e-03 9.9e-03
4 Brain mRNA stability Fosb 0.08 0.12 7.2e-04 0.04 0.03 0.02 0.03 2.9e-04 9.2e-04 5.0e-03 3.7e-04
5 BLA gene expression Fosb 0.06 0.06 3.6e-03 0.03 0.02 0.02 0.02 1.3e-02 3.1e-02 4.0e-02 4.8e-02
6 NAcc gene expression Fosb 0.02 0.02 8.5e-04 0.01 0.01 0.01 0.01 2.9e-02 1.1e-02 3.0e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.00.1-0.10.1-0.1-0.4-0.20.0
Area under the delay curve1.32.12.61.61.4-1.41.4-1.51.4
BMI with tail0.51.92.1-1.4-1.41.4-1.31.2-1.4
BMI without tail0.42.02.3-1.5-1.41.4-1.41.3-1.4
Body weight1.15.05.5-2.4-2.32.3-2.12.1-2.2
Weight adjusted by age0.00.00.00.0-0.10.10.1-0.0-0.0
Bone surface0.20.50.8-0.8-0.60.6-0.90.6-0.7
Bone volume0.20.40.7-0.7-0.40.4-0.90.4-0.5
Breakpoint value in progressive ratio session1.52.83.21.81.7-1.71.7-1.51.6
Number of licking bursts1.33.94.4-1.9-2.12.1-1.72.1-1.9
Context. condit. distance diff. score0.10.10.2-0.4-0.30.3-0.20.3-0.4
Locomotion velocity, session 10.10.10.20.40.3-0.30.4-0.30.2
Locomotion distance, session 10.00.00.1-0.2-0.10.1-0.30.1-0.2
Locomotion velocity, session 21.21.51.6-1.2-1.31.3-1.11.2-1.2
Locomotion distance, session 20.30.40.6-0.7-0.50.5-0.80.5-0.6
Locomotion velocity, session 30.20.30.4-0.6-0.50.5-0.50.4-0.5
Locomotion distance, session 30.70.80.90.90.9-0.90.9-0.90.9
Stereotopy head waving bouts, day 30.91.11.3-1.0-1.11.1-0.81.1-1.0
Stereotopy head waving duration, day 31.11.31.5-1.2-1.21.2-1.01.2-1.1
Locomotion velocity, session 70.10.10.20.30.4-0.40.3-0.40.4
Locomotion distance, session 70.00.00.0-0.2-0.20.2-0.10.2-0.2
Stereotopy head waving bouts, day 71.01.11.3-1.1-1.01.0-1.01.1-1.1
Stereotopy head waving duration, day 70.81.01.1-1.0-1.01.0-0.91.0-1.0
Locomotion velocity, session 80.00.00.00.10.0-0.00.2-0.10.1
Locomotion distance, session 80.00.00.0-0.20.0-0.0-0.2-0.0-0.1
Degree of sensitization distance0.60.60.7-0.8-0.80.8-0.70.8-0.8
Degree of sensitization stereotypy1.01.11.3-1.1-1.01.0-1.11.1-1.1
Conditioned locomotion0.00.00.10.20.2-0.20.1-0.30.2
Cocaine response after cond. corrected0.50.70.8-0.9-0.80.8-0.80.9-0.8
Cocaine response after cond. not corrected1.21.71.9-1.4-1.31.3-1.31.3-1.3
Cocaine response before conditioning1.62.02.1-1.5-1.41.4-1.41.3-1.4
Saline control response2.12.93.8-1.9-1.61.6-1.71.7-1.7
Bone: connectivity density0.00.10.10.10.3-0.3-0.2-0.30.2
Bone: cortical apparent density0.10.10.20.20.4-0.40.1-0.40.3
Bone: cortical area1.62.53.0-1.7-1.61.6-1.61.6-1.6
Bone: cortical porosity0.20.20.60.50.4-0.40.8-0.30.4
Bone: cortical porosity0.00.00.20.10.0-0.00.40.10.1
Bone: cortical thickness0.61.01.3-1.1-1.01.0-1.00.9-1.0
Bone: cortical thickness1.51.82.0-1.4-1.41.4-1.41.2-1.3
Bone: cortical tissue density0.10.20.30.30.5-0.50.2-0.50.4
Condit. Reinf. active minus inactive responses0.30.40.5-0.7-0.60.6-0.70.5-0.6
Condit. Reinf. active-inactive response ratio0.30.30.6-0.7-0.40.4-0.80.3-0.5
Condit. Reinf. active responses0.20.30.5-0.6-0.40.4-0.70.3-0.5
Condit. Reinf. inactive responses0.00.00.10.10.2-0.2-0.0-0.30.2
Incentive salience index mean0.20.20.3-0.5-0.40.4-0.60.4-0.5
Condit. Reinf. lever presses0.00.00.0-0.1-0.10.1-0.10.1-0.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.4-0.30.3-0.50.2-0.3
Condit. Reinf. active-inactive response ratio0.30.50.8-0.8-0.60.6-0.90.6-0.7
Condit. Reinf. active responses0.10.10.20.30.2-0.20.2-0.40.3
Condit. Reinf. inactive responses0.60.91.11.00.9-0.90.9-1.01.0
Condit. Reinf. lever presses0.10.20.3-0.4-0.50.5-0.60.3-0.4
Condit. Reinf. lever reinforcers received0.10.10.20.40.3-0.30.2-0.40.3
Conditioned reinforcement - actives0.62.32.4-1.6-1.51.5-1.51.4-1.5
Conditioned reinforcement - inactives0.20.60.7-0.8-0.70.7-0.70.8-0.7
Conditioned locomotion2.13.13.4-1.8-1.81.8-1.71.7-1.7
Patch foraging indifference point 0 sec0.30.80.9-0.9-0.90.9-1.00.9-0.9
Patch foraging indifference point AUC1.94.45.0-2.2-2.22.2-1.82.2-2.1
Delay disc. indifference point, 0s delay1.31.51.81.31.2-1.21.2-1.21.2
Delay disc. indifference point, 16s delay1.01.41.71.31.1-1.11.1-1.21.1
Delay disc. indifference point, 2s delay3.74.25.12.21.9-1.92.2-2.12.0
Delay disc. indifference point, 24s delay0.00.10.2-0.3-0.20.2-0.4-0.0-0.2
Delay disc. indifference point, 4s delay0.00.00.00.1-0.00.00.1-0.10.0
Delay disc. indifference point, 8s delay1.21.92.31.51.4-1.41.3-1.41.4
Indifference point function ln k0.51.41.71.21.3-1.30.9-1.21.1
Indifference point function log k0.51.41.71.21.3-1.30.9-1.21.1
Patch foraging total patch changes 0 sec0.41.31.5-1.2-1.01.0-1.21.1-1.1
Patch foraging total patch changes 12 sec1.31.81.9-1.4-1.41.4-1.21.4-1.3
Patch foraging total patch changes 18 sec1.33.03.5-1.9-1.61.6-1.81.8-1.7
Patch foraging total patch changes 24 sec0.10.50.6-0.8-0.60.6-0.70.7-0.7
Patch foraging total patch changes 6 sec2.44.14.8-2.2-2.02.0-2.12.0-1.9
Patch foraging time to switch 0 sec1.45.46.32.52.3-2.32.4-2.22.3
Patch foraging water rate 0 sec1.66.17.1-2.7-2.42.4-2.52.4-2.5
Patch foraging water rate 12 sec0.10.30.5-0.6-0.40.4-0.70.4-0.5
Patch foraging water rate 18 sec0.10.20.3-0.5-0.30.3-0.50.3-0.4
Patch foraging water rate 24 sec0.60.81.0-1.0-0.90.9-1.00.8-0.9
Patch foraging water rate 6 sec0.61.01.3-1.1-0.90.9-1.10.8-1.0
Seeking ratio, delayed vs. immediate footshock1.72.42.61.61.6-1.61.5-1.51.5
Distance traveled before self-admin0.10.10.3-0.4-0.30.3-0.50.2-0.3
Distance traveled after self-admin0.10.20.20.40.4-0.40.3-0.50.4
Extensor digitorum longus weight1.87.08.6-2.9-2.52.5-2.52.7-2.7
Bone: elastic displacement1.11.41.71.11.3-1.31.3-1.01.1
Bone: elastic work0.00.00.0-0.2-0.00.0-0.00.1-0.1
Bone: endosteal estimation0.00.10.10.30.3-0.30.4-0.20.2
Bone: endosteal perimeter0.00.00.00.1-0.00.00.10.10.0
Epididymis fat weight0.20.91.41.10.8-0.81.2-0.80.9
Delta time in closed arm before/after self-admin0.10.10.20.50.3-0.30.4-0.40.3
Delta time in open arm before/after self-admin0.00.00.00.00.2-0.2-0.1-0.10.2
Diff in mean of infusions in LGA sessions0.91.71.91.41.3-1.31.3-1.21.3
Delay discount exponential model param1.11.51.8-1.4-1.11.1-1.21.3-1.2
Extinction: sum of active levers before priming0.10.10.20.30.3-0.30.4-0.10.3
Active lever presses in extinction session 60.10.10.1-0.3-0.20.2-0.20.4-0.3
Bone: final force0.40.60.7-0.8-0.80.8-0.80.8-0.8
Bone: final moment0.60.91.0-1.0-1.01.0-0.90.9-0.9
Food consumed during 24 hour testing period3.77.48.32.92.8-2.82.5-2.72.6
Glucose0.30.40.60.80.5-0.50.8-0.60.6
Heart weight2.33.74.1-2.0-1.91.9-1.81.9-1.9
Delay discount hyperbolic model param1.01.31.7-1.3-1.01.0-1.11.2-1.1
Intermittent access intake day 1-15 change0.00.20.2-0.4-0.40.4-0.40.3-0.4
Intermittent access intake escalation0.00.20.3-0.5-0.50.5-0.50.4-0.5
Intermittent access intake escalation 20.00.00.0-0.1-0.10.1-0.10.0-0.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1-0.00.0-0.00.0-0.1
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.00.0-0.00.0-0.0
Intermitt. access escalation Index0.10.30.40.60.6-0.60.5-0.50.5
Intermittent access day 1 total infusions0.82.42.9-1.7-1.51.5-1.51.5-1.5
Intermittent access day 15 total infusions0.51.11.3-1.1-1.11.1-1.01.0-1.0
Intermittent access terminal intake (last 3 days)0.91.51.7-1.3-1.31.3-1.21.1-1.2
Intermittent access total infusions2.53.03.4-1.8-1.71.7-1.71.7-1.7
Intermittent access day 1 locomotion0.20.40.4-0.6-0.60.6-0.60.6-0.6
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.50.5-0.50.5-0.5
Intermittent access total locomotion1.72.02.3-1.5-1.41.4-1.41.4-1.4
Intermittent access standard deviation0.00.20.30.50.4-0.40.5-0.50.5
Left kidney weight3.427.031.5-5.6-5.15.1-5.34.9-5.1
Right kidney weight3.424.027.7-5.3-4.84.8-4.94.7-4.9
Cocaine induced anxiety0.10.30.30.50.6-0.60.6-0.40.5
Post-drug Anxiety0.00.10.10.20.3-0.30.3-0.10.2
Baseline Anxiety0.00.00.0-0.1-0.00.0-0.00.0-0.0
Tail length0.31.41.8-1.4-1.21.2-1.21.2-1.1
Length with tail0.31.51.9-1.4-1.21.2-1.31.2-1.2
Length without tail0.21.11.4-1.1-1.01.0-1.21.0-1.1
Times rat made contact with spout0.00.00.00.00.2-0.2-0.1-0.20.0
Lifetime Intake2.43.03.4-1.8-1.71.7-1.71.7-1.7
Liver weight, left2.13.64.0-2.0-1.91.9-1.72.0-1.9
Liver weight, right1.42.43.1-1.7-1.41.4-1.71.4-1.5
Locomotor activity2.53.84.4-2.1-2.02.0-1.91.9-1.9
Locomotor testing distance1.02.42.9-1.7-1.51.5-1.51.6-1.5
Locomotor testing rearing2.59.210.6-3.3-3.03.0-3.03.0-3.0
Locomotion in novel chamber0.10.20.30.40.3-0.30.5-0.50.4
Locomotion in novel chamber post-restriction0.51.51.71.31.3-1.31.2-1.11.1
Fecal boli incidents, locomotor time 10.00.00.1-0.2-0.20.2-0.10.3-0.2
Change in fecal boli incidents, locomotor task0.80.81.01.00.9-0.90.9-0.90.9
Time >=10cm from walls, locomotor time 10.00.00.0-0.20.1-0.1-0.1-0.10.0
Bouts of movement, locomotor time 12.12.72.91.61.7-1.71.5-1.71.6
Total resting periods, locomotor time 13.03.43.71.91.9-1.91.7-1.91.9
Rest time, locomotor task time 10.10.20.20.40.5-0.50.4-0.40.5
Distance moved, locomotor task time 10.20.50.6-0.6-0.80.8-0.50.7-0.7
Vertical activity count, locomotor time 10.00.00.00.10.0-0.00.10.00.1
Time >=10cm from walls, locomotor time 20.00.10.20.40.2-0.20.4-0.20.3
Bouts of movement, locomotor time 22.27.38.12.82.7-2.72.5-2.82.7
Total resting periods, locomotor time 21.66.47.12.62.5-2.52.3-2.72.5
Rest time, locomotor task time 20.00.00.1-0.00.3-0.3-0.0-0.20.2
Distance moved, locomotor task time 20.60.81.0-0.8-1.01.0-0.70.9-0.9
Vertical activity count, locomotor time 20.10.10.30.50.2-0.20.4-0.20.3
Light reinforcement 10.00.20.4-0.6-0.20.2-0.70.4-0.4
Light reinforcement 20.10.10.2-0.5-0.30.3-0.40.4-0.3
Bone: marrow area0.00.10.10.20.2-0.20.3-0.10.2
Bone: maximum diameter2.14.24.5-2.1-2.12.1-1.92.1-2.0
Bone: maximum force0.20.30.4-0.6-0.60.6-0.60.5-0.5
Bone: maximum moment0.20.40.5-0.6-0.70.7-0.60.6-0.6
Mean time between licks in bursts0.00.10.10.30.3-0.30.1-0.30.3
Mean num. licks in bursts1.54.04.71.92.2-2.21.6-2.21.9
Cd content in liver0.00.10.10.20.3-0.30.0-0.30.2
Co content in liver1.31.61.91.41.2-1.21.3-1.21.2
Cu content in liver0.30.40.5-0.6-0.60.6-0.50.7-0.6
Fe content in liver5.26.47.1-2.7-2.62.6-2.42.5-2.5
K content in liver0.10.10.2-0.2-0.40.4-0.10.5-0.3
Mg content in liver0.50.50.6-0.6-0.80.8-0.50.8-0.7
Mn content in liver0.91.01.1-1.1-1.01.0-1.01.0-1.0
Na content in liver0.20.20.4-0.4-0.40.4-0.20.6-0.4
Rb content in liver0.10.10.1-0.3-0.20.2-0.40.3-0.3
Se content in liver3.94.65.1-2.2-2.22.2-2.02.2-2.1
Sr content in liver0.00.00.0-0.2-0.20.2-0.00.2-0.1
Zn content in liver0.70.81.0-0.8-0.90.9-0.71.0-0.9
Bone: minimum diameter0.20.30.4-0.7-0.50.5-0.50.6-0.6
Time in familiar zone, hab. session 10.20.20.3-0.4-0.50.5-0.40.5-0.4
Time in novel zone, hab. session 10.50.50.6-0.8-0.80.8-0.70.7-0.7
Total zone transitions, hab. session 10.20.30.4-0.6-0.40.4-0.60.4-0.5
Total locomotion distance, hab. session 10.40.50.60.80.7-0.70.6-0.80.7
Locomotion velocity, hab. session 11.21.81.91.41.3-1.31.2-1.41.3
Time in familiar zone, hab. session 20.20.30.3-0.5-0.50.5-0.50.6-0.5
Time in novel zone, hab. session 20.00.00.10.30.2-0.20.2-0.30.2
Total zone transitions, hab. session 20.50.70.7-0.9-0.80.8-0.70.9-0.8
Total locomotion distance, hab. session 20.60.70.90.90.8-0.80.9-0.80.8
Locomotion velocity, hab. session 20.30.50.50.70.7-0.70.7-0.70.7
Novel to familiar place preference ratio0.60.71.2-1.0-0.70.7-1.10.6-0.9
Novelty place preference0.50.61.0-0.9-0.70.7-1.00.6-0.8
Time in novel zone, NPP test0.70.81.1-1.0-0.80.8-1.10.7-0.9
Total zone transitions, NPP test0.10.20.2-0.4-0.40.4-0.40.4-0.4
Total locomotion distance, NPP test0.10.10.2-0.4-0.40.4-0.40.4-0.4
Locomotion velocity, NPP test0.10.10.1-0.3-0.30.3-0.40.3-0.3
Intraocular pressure0.00.00.00.20.1-0.10.1-0.10.0
Delta distance traveled before/after self-admin1.92.12.61.61.4-1.41.5-1.31.4
Delta ambulatory time before/after self-admin0.30.50.60.80.7-0.70.8-0.60.7
Parametrial fat weight0.10.10.2-0.4-0.40.4-0.30.3-0.4
Pavlov. Cond. lever latency0.40.60.70.80.7-0.70.8-0.70.8
Pavlov. Cond. magazine entry latency0.00.10.1-0.2-0.20.2-0.30.2-0.3
Pavlov. Cond. change in total contacts0.60.70.80.90.8-0.80.8-0.90.8
Pavlov. Cond. index score0.20.30.3-0.5-0.50.5-0.50.5-0.5
Pavlov. Cond. latency score0.00.00.0-0.2-0.20.2-0.20.2-0.2
Pavlov. Cond. lever contacts0.30.30.4-0.6-0.50.5-0.60.5-0.6
Pavlov. Cond. magazine entry number0.00.00.00.00.0-0.00.1-0.00.1
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.3-0.30.3-0.30.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.3-0.6-0.50.5-0.60.5-0.6
Pavlov. Cond. response bias0.80.91.2-1.1-0.90.9-1.10.9-1.0
Pavlov. Cond. lever latency0.00.00.00.10.2-0.20.2-0.10.1
Pavlov. Cond. magazine entry latency0.00.00.2-0.2-0.10.1-0.4-0.0-0.2
Pavlov. Cond. change in total contacts0.10.20.30.50.4-0.40.3-0.60.5
Pavlov. Cond. index score0.00.00.10.10.1-0.1-0.1-0.20.1
Pavlov. Cond. latency score0.00.10.10.20.3-0.30.0-0.30.2
Pavlov. Cond. lever contacts0.10.10.1-0.3-0.40.4-0.40.2-0.3
Pavlov. Cond. magazine entry number0.30.40.5-0.7-0.60.6-0.40.7-0.6
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.10.1-0.00.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.10.1-0.3-0.1-0.1
Pavlov. Cond. response bias0.00.00.00.0-0.00.0-0.1-0.10.0
Time in closed arm before self-admin0.71.21.6-1.2-1.01.0-1.30.9-1.0
Time in closed arm after self-admin0.80.91.01.00.9-0.90.9-1.00.9
Time in open arm before self-admin0.91.11.81.21.0-1.01.3-0.81.0
Time in open arm after self-admin0.10.10.20.40.4-0.40.4-0.20.4
Bone: periosteal estimation0.20.50.6-0.8-0.70.7-0.60.8-0.7
Bone: periosteal perimeter0.20.40.5-0.7-0.70.7-0.60.7-0.6
Bone: post-yield work0.61.01.21.01.0-1.00.7-1.11.0
Progressive ratio test 1 active lever presses1.93.33.8-1.9-1.81.8-1.81.8-1.8
Progressive ratio test 1 breakpoint1.72.93.3-1.8-1.71.7-1.71.6-1.7
Progressive ratio test 1 inactive lever presses0.71.92.3-1.5-1.41.4-1.31.3-1.4
Progressive ratio test 2 active lever presses1.82.63.1-1.8-1.61.6-1.51.7-1.6
Progressive ratio test 2 breakpoint2.32.93.4-1.9-1.71.7-1.61.8-1.7
Progressive ratio test 2 inactive lever presses0.10.20.2-0.5-0.40.4-0.30.5-0.4
Incentive Sensitization - Responses0.61.51.8-1.4-1.21.2-1.11.3-1.2
Incentive Sensitization - Breakpoint0.61.41.6-1.3-1.11.1-1.11.2-1.2
Sum of active levers in priming session hrs 5-60.30.30.30.50.5-0.50.6-0.40.5
Progressive ratio0.61.82.01.41.4-1.41.4-1.21.3
Food seeking constrained by brief footshock5.16.47.22.72.5-2.52.4-2.52.6
Seeking ratio, punishment vs. effort0.30.70.80.90.8-0.80.7-0.90.9
Retroperitoneal fat weight0.00.10.2-0.3-0.40.4-0.10.4-0.3
Reaction time number correct2.38.09.3-3.1-2.72.7-2.92.7-2.8
Reaction time mean minus median0.00.10.20.40.3-0.30.3-0.40.3
Reaction time mean minus median AUC0.00.20.2-0.4-0.40.4-0.50.3-0.4
Reaction time num false alarms3.66.17.2-2.7-2.42.4-2.52.4-2.5
Reaction time num false alarms AUC2.35.26.2-2.5-2.22.2-2.32.3-2.3
Reaction time trials correct on left2.38.09.3-3.1-2.72.7-2.92.7-2.8
Reaction time trials on left2.38.09.3-3.0-2.72.7-2.92.7-2.8
Reaction time mean0.81.81.91.41.4-1.41.1-1.41.3
Reaction time mean AUC0.51.31.51.21.2-1.21.0-1.21.1
Median of all reaction times1.42.22.31.51.5-1.51.3-1.51.5
Reaction time omissions0.00.00.00.00.0-0.00.0-0.1-0.0
Reaction time false alarm rate0.10.10.2-0.4-0.40.4-0.30.4-0.4
Reaction time premature initiation rate0.40.70.70.80.9-0.90.8-0.80.8
Reaction time premature initiations0.10.40.5-0.7-0.50.5-0.70.6-0.7
Std. dev. reaction times0.10.30.40.60.5-0.50.5-0.60.5
Reaction time trials completed2.38.09.3-3.0-2.72.7-2.92.7-2.8
Reaction time trials AUC2.89.711.3-3.4-3.03.0-3.23.0-3.0
Run reversals in cocaine runway, females0.20.30.40.60.4-0.40.5-0.50.5
Run reversals in cocaine runway, males0.40.50.5-0.7-0.70.7-0.70.7-0.7
Latency to leave start box in cocaine runway0.10.10.2-0.4-0.20.2-0.50.1-0.3
Latency to leave start box in cocaine runway, F0.60.80.9-0.9-0.90.9-0.90.7-0.9
Latency to leave start box in cocaine runway, M0.10.10.20.20.4-0.40.1-0.40.3
Std. dev. time between licks in bursts0.00.10.2-0.30.0-0.0-0.5-0.1-0.1
Total sessions with >9 infusions3.94.85.4-2.3-2.22.2-2.12.2-2.2
Short access day 1 total inactive lever presses0.30.60.7-0.8-0.70.7-0.70.8-0.8
Short access day 10 total inactive lever presses0.21.51.71.31.2-1.21.2-1.21.2
Short access day 1 total infusions1.32.63.0-1.7-1.61.6-1.61.7-1.6
Short access day 10 total infusions2.94.75.4-2.3-2.22.2-2.12.1-2.1
Short access total infusions2.02.93.3-1.8-1.71.7-1.61.7-1.7
Short access day 1 locomotion2.54.24.7-2.2-2.02.0-2.02.0-2.0
Short access day 10 total locomotion0.00.00.0-0.1-0.10.1-0.10.0-0.1
Short access total locomotion0.61.01.0-1.0-1.01.0-1.00.9-1.0
One hour access (0.3 mA shock)0.00.00.1-0.2-0.20.2-0.20.1-0.2
Compulsive drug intake0.20.30.4-0.5-0.60.6-0.60.4-0.5
One hour access (shock baseline)0.51.31.5-1.2-1.11.1-1.11.1-1.1
Social response proportion1.01.21.6-1.2-1.01.0-1.31.0-1.1
Social responses0.91.11.4-1.2-1.11.1-1.01.0-1.1
Social time2.94.65.32.32.1-2.12.1-2.32.1
Soleus weight0.10.40.5-0.7-0.50.5-0.60.6-0.6
Bone: stiffness0.81.41.6-1.2-1.21.2-1.21.2-1.1
Tibialis anterior weight3.311.413.6-3.7-3.23.2-3.33.4-3.4
Time to tail flick, vehicle, before self-admin2.63.23.6-1.9-1.81.8-1.71.8-1.8
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.20.2-0.20.1-0.1
Time to tail flick, test, before self-admin0.40.50.50.70.7-0.70.7-0.60.7
Time to tail flick, test, after self-admin0.20.20.30.50.4-0.40.5-0.40.4
Delta time to tail flick, vehicle, before/after SA0.10.10.10.30.3-0.30.3-0.40.3
Delta time to tail flick, test, before/after SA0.70.91.0-1.0-1.01.0-0.90.8-0.9
Tibia length0.20.60.8-0.7-0.80.8-0.90.6-0.7
Ambulatory time before self-admin0.00.00.0-0.10.0-0.0-0.2-0.10.0
Ambulatory time after self-admin0.30.50.50.70.7-0.70.6-0.70.7
Bone: tissue strength0.91.01.11.00.9-0.91.0-1.00.9
Total heroin consumption0.00.00.00.10.1-0.10.1-0.10.1
Bone: trabecular number0.00.10.20.10.3-0.3-0.1-0.40.2
Bone: trabecular spacing0.00.00.1-0.0-0.20.20.10.4-0.2
Bone: trabecular thickness1.31.92.4-1.6-1.31.3-1.51.1-1.3
Bone: trabecular tissue density0.30.50.6-0.7-0.70.7-0.60.6-0.7
Water consumed over 24 hours0.10.20.20.30.5-0.50.2-0.50.4
Number of responses in last shaping day2.73.43.8-1.9-1.91.9-1.81.9-1.8