Hub : Genes

Fosb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	mRNA stability	Fosb	0.16	0.14	3.0e-03	0.08	0.12	0.12	0.12	5.2e-03	9.2e-04	7.3e-04	1.2e-03
2	PL	isoform ratio	XM_039101873.2	0.05	0.12	1.5e-03	0.02	0.02	0.02	0.02	2.0e-03	5.7e-03	4.1e-03	3.0e-03
3	PL	isoform ratio	NM_001256509.1	0.05	0.12	3.8e-03	0.02	0.01	0.01	0.01	5.7e-03	1.4e-02	9.9e-03	1.0e-02
4	Brain	mRNA stability	Fosb	0.08	0.12	7.2e-04	0.04	0.03	0.02	0.03	2.9e-04	9.2e-04	7.3e-03	3.6e-04
5	BLA	gene expression	Fosb	0.06	0.06	3.6e-03	0.03	0.02	0.02	0.02	1.3e-02	3.1e-02	4.0e-02	4.7e-02
6	NAcc	gene expression	Fosb	0.02	0.02	8.5e-04	0.01	0.01	0.01	0.01	2.9e-02	1.1e-02	3.0e-02	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	0.1	-0.1	0.1	0.4	0.2	0.0
Area under the delay curve	1.8	2.1	2.6	-1.6	-1.4	1.4	-1.4	1.5	1.4
BMI with tail	0.5	1.9	2.1	1.4	1.4	-1.4	1.3	-1.2	-1.4
BMI without tail	0.7	2.0	2.3	1.5	1.4	-1.4	1.4	-1.3	-1.4
Body weight	1.1	5.0	5.5	2.4	2.3	-2.3	2.1	-2.1	-2.2
Weight adjusted by age	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.1	0.0	-0.0
Bone surface	0.3	0.5	0.8	0.8	0.6	-0.6	0.9	-0.6	-0.7
Bone volume	0.2	0.4	0.7	0.7	0.4	-0.4	0.9	-0.4	-0.5
Breakpoint value in progressive ratio session	2.3	2.8	3.2	-1.8	-1.7	1.7	-1.7	1.5	1.6
Number of licking bursts	2.4	3.9	4.4	1.9	2.1	-2.1	1.7	-2.1	-1.9
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	0.3	-0.3	0.2	-0.3	-0.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4	0.3	0.2
Locomotion distance, session 1	0.0	0.0	0.1	0.2	0.1	-0.1	0.3	-0.1	-0.2
Locomotion velocity, session 2	1.3	1.5	1.6	1.2	1.3	-1.3	1.1	-1.2	-1.2
Locomotion distance, session 2	0.3	0.4	0.6	0.7	0.5	-0.5	0.8	-0.5	-0.6
Locomotion velocity, session 3	0.2	0.3	0.4	0.6	0.5	-0.5	0.5	-0.4	-0.5
Locomotion distance, session 3	0.8	0.8	0.9	-0.9	-0.9	0.9	-0.9	0.9	0.9
Stereotopy head waving bouts, day 3	0.9	1.1	1.3	1.0	1.1	-1.1	0.8	-1.1	-1.0
Stereotopy head waving duration, day 3	1.1	1.3	1.5	1.2	1.2	-1.2	1.0	-1.2	-1.1
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.3	0.4	0.4
Locomotion distance, session 7	0.0	0.0	0.0	0.2	0.2	-0.2	0.1	-0.2	-0.2
Stereotopy head waving bouts, day 7	1.0	1.1	1.3	1.1	1.0	-1.0	1.0	-1.1	-1.1
Stereotopy head waving duration, day 7	0.8	1.0	1.1	1.0	1.0	-1.0	0.9	-1.0	-1.0
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.2	0.1	0.1
Locomotion distance, session 8	0.0	0.0	0.0	0.2	-0.0	0.0	0.2	0.0	-0.1
Degree of sensitization distance	0.6	0.6	0.7	0.8	0.8	-0.8	0.7	-0.8	-0.8
Degree of sensitization stereotypy	1.1	1.1	1.3	1.1	1.0	-1.0	1.1	-1.1	-1.1
Conditioned locomotion	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	0.3	0.2
Cocaine response after cond. corrected	0.6	0.7	0.8	0.9	0.8	-0.8	0.8	-0.9	-0.8
Cocaine response after cond. not corrected	1.5	1.7	1.9	1.4	1.3	-1.3	1.3	-1.3	-1.3
Cocaine response before conditioning	1.6	2.0	2.1	1.5	1.4	-1.4	1.4	-1.3	-1.4
Saline control response	2.2	2.9	3.8	1.9	1.6	-1.6	1.7	-1.7	-1.7
Bone: connectivity density	0.0	0.1	0.1	-0.1	-0.3	0.3	0.2	0.3	0.2
Bone: cortical apparent density	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.1	0.4	0.3
Bone: cortical area	1.7	2.5	3.0	1.7	1.6	-1.6	1.6	-1.6	-1.6
Bone: cortical porosity	0.2	0.2	0.6	-0.5	-0.4	0.4	-0.8	0.3	0.4
Bone: cortical porosity	0.0	0.0	0.2	-0.1	-0.0	0.0	-0.4	-0.1	0.1
Bone: cortical thickness	0.6	1.0	1.3	1.1	1.0	-1.0	1.0	-0.9	-1.0
Bone: cortical thickness	1.5	1.8	2.0	1.4	1.4	-1.4	1.4	-1.2	-1.3
Bone: cortical tissue density	0.1	0.2	0.3	-0.3	-0.5	0.5	-0.2	0.5	0.4
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	0.7	0.6	-0.6	0.7	-0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.7	0.4	-0.4	0.8	-0.3	-0.5
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	0.4	-0.4	0.7	-0.3	-0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.2	0.2	0.0	0.3	0.2
Incentive salience index mean	0.2	0.2	0.3	0.5	0.4	-0.4	0.6	-0.4	-0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	0.3	-0.3	0.5	-0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.8	0.6	-0.6	0.9	-0.6	-0.7
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.2	0.4	0.3
Condit. Reinf. inactive responses	0.7	0.9	1.1	-1.0	-0.9	0.9	-0.9	1.0	1.0
Condit. Reinf. lever presses	0.2	0.2	0.3	0.4	0.5	-0.5	0.6	-0.3	-0.4
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.2	0.4	0.3
Conditioned reinforcement - actives	1.3	2.3	2.4	1.6	1.5	-1.5	1.5	-1.4	-1.5
Conditioned reinforcement - inactives	0.4	0.6	0.7	0.8	0.7	-0.7	0.7	-0.8	-0.7
Conditioned locomotion	2.4	3.1	3.4	1.8	1.8	-1.8	1.7	-1.7	-1.7
Patch foraging indifference point 0 sec	0.4	0.8	0.9	0.9	0.9	-0.9	1.0	-0.9	-0.9
Patch foraging indifference point AUC	3.1	4.4	5.0	2.2	2.2	-2.2	1.8	-2.2	-2.1
Delay disc. indifference point, 0s delay	1.4	1.5	1.8	-1.3	-1.2	1.2	-1.2	1.2	1.2
Delay disc. indifference point, 16s delay	1.3	1.4	1.7	-1.3	-1.1	1.1	-1.1	1.2	1.1
Delay disc. indifference point, 2s delay	3.7	4.2	5.1	-2.2	-1.9	1.9	-2.2	2.1	2.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	0.2	-0.2	0.4	0.0	-0.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	0.1	0.0
Delay disc. indifference point, 8s delay	1.7	1.9	2.3	-1.5	-1.4	1.4	-1.3	1.4	1.4
Indifference point function ln k	0.8	1.4	1.7	-1.2	-1.3	1.3	-0.9	1.2	1.1
Indifference point function log k	0.8	1.4	1.7	-1.2	-1.3	1.3	-0.9	1.2	1.1
Patch foraging total patch changes 0 sec	0.7	1.3	1.5	1.2	1.0	-1.0	1.2	-1.1	-1.1
Patch foraging total patch changes 12 sec	1.4	1.8	1.9	1.4	1.4	-1.4	1.2	-1.4	-1.3
Patch foraging total patch changes 18 sec	2.0	3.0	3.5	1.9	1.6	-1.6	1.8	-1.8	-1.7
Patch foraging total patch changes 24 sec	0.3	0.5	0.6	0.8	0.6	-0.6	0.7	-0.7	-0.7
Patch foraging total patch changes 6 sec	2.7	4.1	4.8	2.2	2.0	-2.0	2.1	-2.0	-1.9
Patch foraging time to switch 0 sec	2.6	5.4	6.3	-2.5	-2.3	2.3	-2.4	2.2	2.3
Patch foraging water rate 0 sec	2.9	6.1	7.1	2.7	2.4	-2.4	2.5	-2.4	-2.5
Patch foraging water rate 12 sec	0.1	0.3	0.5	0.6	0.4	-0.4	0.7	-0.4	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.5	0.3	-0.3	0.5	-0.3	-0.4
Patch foraging water rate 24 sec	0.6	0.8	1.0	1.0	0.9	-0.9	1.0	-0.8	-0.9
Patch foraging water rate 6 sec	0.7	1.0	1.3	1.1	0.9	-0.9	1.1	-0.8	-1.0
Seeking ratio, delayed vs. immediate footshock	2.0	2.4	2.6	-1.6	-1.6	1.6	-1.5	1.5	1.5
Distance traveled before self-admin	0.1	0.1	0.3	0.4	0.3	-0.3	0.5	-0.2	-0.3
Distance traveled after self-admin	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.3	0.5	0.4
Extensor digitorum longus weight	1.8	7.0	8.6	2.9	2.5	-2.5	2.5	-2.7	-2.7
Bone: elastic displacement	1.2	1.4	1.7	-1.1	-1.3	1.3	-1.3	1.0	1.1
Bone: elastic work	0.0	0.0	0.0	0.2	0.0	-0.0	0.0	-0.1	-0.1
Bone: endosteal estimation	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.4	0.2	0.2
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	-0.1	0.0
Epididymis fat weight	0.3	0.9	1.4	-1.1	-0.8	0.8	-1.2	0.8	0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.4	0.4	0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.2	0.2	0.1	0.1	0.2
Diff in mean of infusions in LGA sessions	1.4	1.7	1.9	-1.4	-1.3	1.3	-1.3	1.2	1.3
Delay discount exponential model param	1.3	1.5	1.8	1.4	1.1	-1.1	1.2	-1.3	-1.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.4	0.1	0.3
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.2	-0.2	0.2	-0.4	-0.3
Bone: final force	0.4	0.6	0.7	0.8	0.8	-0.8	0.8	-0.8	-0.8
Bone: final moment	0.6	0.9	1.0	1.0	1.0	-1.0	0.9	-0.9	-0.9
Food consumed during 24 hour testing period	5.3	7.4	8.3	-2.9	-2.8	2.8	-2.5	2.7	2.6
Glucose	0.3	0.4	0.6	-0.8	-0.5	0.5	-0.8	0.6	0.6
Heart weight	2.4	3.7	4.1	2.0	1.9	-1.9	1.8	-1.9	-1.9
Delay discount hyperbolic model param	1.2	1.3	1.7	1.3	1.0	-1.0	1.1	-1.2	-1.1
Intermittent access intake day 1-15 change	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	-0.3	-0.4
Intermittent access intake escalation	0.1	0.2	0.3	0.5	0.5	-0.5	0.5	-0.4	-0.5
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	-0.0	-0.1
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Intermitt. access escalation Index	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.5	0.5	0.5
Intermittent access day 1 total infusions	1.5	2.4	2.9	1.7	1.5	-1.5	1.5	-1.5	-1.5
Intermittent access day 15 total infusions	0.8	1.1	1.3	1.1	1.1	-1.1	1.0	-1.0	-1.0
Intermittent access terminal intake (last 3 days)	1.2	1.5	1.7	1.3	1.3	-1.3	1.2	-1.1	-1.2
Intermittent access total infusions	2.5	3.0	3.4	1.8	1.7	-1.7	1.7	-1.7	-1.7
Intermittent access day 1 locomotion	0.3	0.4	0.4	0.6	0.6	-0.6	0.6	-0.6	-0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.5	0.5	-0.5	0.5	-0.5	-0.5
Intermittent access total locomotion	1.7	2.0	2.3	1.5	1.4	-1.4	1.4	-1.4	-1.4
Intermittent access standard deviation	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.5	0.5	0.5
Left kidney weight	5.8	27.0	31.5	5.6	5.1	-5.1	5.3	-4.9	-5.1
Right kidney weight	5.3	24.0	27.7	5.3	4.8	-4.8	4.9	-4.7	-4.9
Cocaine induced anxiety	0.2	0.3	0.3	-0.5	-0.6	0.6	-0.6	0.4	0.5
Post-drug Anxiety	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3	0.1	0.2
Baseline Anxiety	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	-0.0	-0.0
Tail length	0.4	1.4	1.8	1.4	1.2	-1.2	1.2	-1.2	-1.1
Length with tail	0.4	1.5	1.9	1.4	1.2	-1.2	1.3	-1.2	-1.2
Length without tail	0.3	1.1	1.4	1.1	1.0	-1.0	1.2	-1.0	-1.1
Times rat made contact with spout	0.0	0.0	0.0	-0.0	-0.2	0.2	0.1	0.2	0.0
Lifetime Intake	2.4	3.0	3.4	1.8	1.7	-1.7	1.7	-1.7	-1.7
Liver weight, left	2.1	3.6	4.0	2.0	1.9	-1.9	1.7	-2.0	-1.9
Liver weight, right	1.4	2.4	3.1	1.7	1.4	-1.4	1.7	-1.4	-1.5
Locomotor activity	2.5	3.8	4.4	2.1	2.0	-2.0	1.9	-1.9	-1.9
Locomotor testing distance	1.3	2.4	2.9	1.7	1.5	-1.5	1.5	-1.6	-1.5
Locomotor testing rearing	4.6	9.2	10.6	3.3	3.0	-3.0	3.0	-3.0	-3.0
Locomotion in novel chamber	0.1	0.2	0.3	-0.4	-0.3	0.3	-0.5	0.5	0.4
Locomotion in novel chamber post-restriction	0.9	1.5	1.7	-1.3	-1.3	1.3	-1.2	1.1	1.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.2	0.2	-0.2	0.1	-0.3	-0.2
Change in fecal boli incidents, locomotor task	0.8	0.8	1.0	-1.0	-0.9	0.9	-0.9	0.9	0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	0.1	0.0
Bouts of movement, locomotor time 1	2.3	2.7	2.9	-1.6	-1.7	1.7	-1.5	1.7	1.6
Total resting periods, locomotor time 1	3.1	3.4	3.7	-1.9	-1.9	1.9	-1.7	1.9	1.9
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.4	-0.5	0.5	-0.4	0.4	0.5
Distance moved, locomotor task time 1	0.3	0.5	0.6	0.6	0.8	-0.8	0.5	-0.7	-0.7
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	-0.0	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.4	0.2	0.3
Bouts of movement, locomotor time 2	4.6	7.3	8.1	-2.8	-2.7	2.7	-2.5	2.8	2.7
Total resting periods, locomotor time 2	3.7	6.4	7.1	-2.6	-2.5	2.5	-2.3	2.7	2.5
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.3	0.3	0.0	0.2	0.2
Distance moved, locomotor task time 2	0.7	0.8	1.0	0.8	1.0	-1.0	0.7	-0.9	-0.9
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.4	0.2	0.3
Light reinforcement 1	0.1	0.2	0.4	0.6	0.2	-0.2	0.7	-0.4	-0.4
Light reinforcement 2	0.1	0.1	0.2	0.5	0.3	-0.3	0.4	-0.4	-0.3
Bone: marrow area	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3	0.1	0.2
Bone: maximum diameter	2.2	4.2	4.5	2.1	2.1	-2.1	1.9	-2.1	-2.0
Bone: maximum force	0.2	0.3	0.4	0.6	0.6	-0.6	0.6	-0.5	-0.5
Bone: maximum moment	0.2	0.4	0.5	0.6	0.7	-0.7	0.6	-0.6	-0.6
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.1	0.3	0.3
Mean num. licks in bursts	2.6	4.0	4.7	-1.9	-2.2	2.2	-1.6	2.2	1.9
Cd content in liver	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.0	0.3	0.2
Co content in liver	1.3	1.6	1.9	-1.4	-1.2	1.2	-1.3	1.2	1.2
Cu content in liver	0.3	0.4	0.5	0.6	0.6	-0.6	0.5	-0.7	-0.6
Fe content in liver	5.3	6.4	7.1	2.7	2.6	-2.6	2.4	-2.5	-2.5
K content in liver	0.1	0.1	0.2	0.2	0.4	-0.4	0.1	-0.5	-0.3
Mg content in liver	0.5	0.5	0.6	0.6	0.8	-0.8	0.5	-0.8	-0.7
Mn content in liver	0.9	1.0	1.1	1.1	1.0	-1.0	1.0	-1.0	-1.0
Na content in liver	0.2	0.2	0.4	0.4	0.4	-0.4	0.2	-0.6	-0.4
Rb content in liver	0.1	0.1	0.1	0.3	0.2	-0.2	0.4	-0.3	-0.3
Se content in liver	3.9	4.6	5.1	2.2	2.2	-2.2	2.0	-2.2	-2.1
Sr content in liver	0.0	0.0	0.0	0.2	0.2	-0.2	0.0	-0.2	-0.1
Zn content in liver	0.7	0.8	1.0	0.8	0.9	-0.9	0.7	-1.0	-0.9
Bone: minimum diameter	0.2	0.3	0.4	0.7	0.5	-0.5	0.5	-0.6	-0.6
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	0.5	-0.5	0.4	-0.5	-0.4
Time in novel zone, hab. session 1	0.5	0.5	0.6	0.8	0.8	-0.8	0.7	-0.7	-0.7
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.6	0.4	-0.4	0.6	-0.4	-0.5
Total locomotion distance, hab. session 1	0.4	0.5	0.6	-0.8	-0.7	0.7	-0.6	0.8	0.7
Locomotion velocity, hab. session 1	1.2	1.8	1.9	-1.4	-1.3	1.3	-1.2	1.4	1.3
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.5	0.5	-0.5	0.5	-0.6	-0.5
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	0.3	0.2
Total zone transitions, hab. session 2	0.5	0.7	0.7	0.9	0.8	-0.8	0.7	-0.9	-0.8
Total locomotion distance, hab. session 2	0.6	0.7	0.9	-0.9	-0.8	0.8	-0.9	0.8	0.8
Locomotion velocity, hab. session 2	0.3	0.5	0.5	-0.7	-0.7	0.7	-0.7	0.7	0.7
Novel to familiar place preference ratio	0.7	0.7	1.2	1.0	0.7	-0.7	1.1	-0.6	-0.9
Novelty place preference	0.6	0.6	1.0	0.9	0.7	-0.7	1.0	-0.6	-0.8
Time in novel zone, NPP test	0.8	0.8	1.1	1.0	0.8	-0.8	1.1	-0.7	-0.9
Total zone transitions, NPP test	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	-0.4	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	0.4	-0.4	0.4	-0.4	-0.4
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	0.3	-0.3	0.4	-0.3	-0.3
Intraocular pressure	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1	0.1	0.0
Delta distance traveled before/after self-admin	2.0	2.1	2.6	-1.6	-1.4	1.4	-1.5	1.3	1.4
Delta ambulatory time before/after self-admin	0.4	0.5	0.6	-0.8	-0.7	0.7	-0.8	0.6	0.7
Parametrial fat weight	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	-0.3	-0.4
Pavlov. Cond. lever latency	0.4	0.6	0.7	-0.8	-0.7	0.7	-0.8	0.7	0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.2	0.2	-0.2	0.3	-0.2	-0.3
Pavlov. Cond. change in total contacts	0.7	0.7	0.8	-0.9	-0.8	0.8	-0.8	0.9	0.8
Pavlov. Cond. index score	0.2	0.3	0.3	0.5	0.5	-0.5	0.5	-0.5	-0.5
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	-0.2	-0.2
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.6	0.5	-0.5	0.6	-0.5	-0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.6	0.5	-0.5	0.6	-0.5	-0.6
Pavlov. Cond. response bias	0.8	0.9	1.2	1.1	0.9	-0.9	1.1	-0.9	-1.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2	0.1	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	0.2	0.1	-0.1	0.4	0.0	-0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.3	0.6	0.5
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.2	0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.0	0.3	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.4	-0.4	0.4	-0.2	-0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.7	0.6	-0.6	0.4	-0.7	-0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.1	0.1	-0.1	0.3	0.1	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1	0.1	0.0
Time in closed arm before self-admin	0.9	1.2	1.6	1.2	1.0	-1.0	1.3	-0.9	-1.0
Time in closed arm after self-admin	0.8	0.9	1.0	-1.0	-0.9	0.9	-0.9	1.0	0.9
Time in open arm before self-admin	1.0	1.1	1.8	-1.2	-1.0	1.0	-1.3	0.8	1.0
Time in open arm after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	0.2	0.4
Bone: periosteal estimation	0.2	0.5	0.6	0.8	0.7	-0.7	0.6	-0.8	-0.7
Bone: periosteal perimeter	0.3	0.4	0.5	0.7	0.7	-0.7	0.6	-0.7	-0.6
Bone: post-yield work	0.7	1.0	1.2	-1.0	-1.0	1.0	-0.7	1.1	1.0
Progressive ratio test 1 active lever presses	2.6	3.3	3.8	1.9	1.8	-1.8	1.8	-1.8	-1.8
Progressive ratio test 1 breakpoint	2.4	2.9	3.3	1.8	1.7	-1.7	1.7	-1.6	-1.7
Progressive ratio test 1 inactive lever presses	1.3	1.9	2.3	1.5	1.4	-1.4	1.3	-1.3	-1.4
Progressive ratio test 2 active lever presses	2.2	2.6	3.1	1.8	1.6	-1.6	1.5	-1.7	-1.6
Progressive ratio test 2 breakpoint	2.5	2.9	3.4	1.9	1.7	-1.7	1.6	-1.8	-1.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.5	0.4	-0.4	0.3	-0.5	-0.4
Incentive Sensitization - Responses	1.1	1.5	1.8	1.4	1.2	-1.2	1.1	-1.3	-1.2
Incentive Sensitization - Breakpoint	1.0	1.4	1.6	1.3	1.1	-1.1	1.1	-1.2	-1.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.3	-0.5	-0.5	0.5	-0.6	0.4	0.5
Progressive ratio	1.2	1.8	2.0	-1.4	-1.4	1.4	-1.4	1.2	1.3
Food seeking constrained by brief footshock	5.2	6.4	7.2	-2.7	-2.5	2.5	-2.4	2.5	2.6
Seeking ratio, punishment vs. effort	0.5	0.7	0.8	-0.9	-0.8	0.8	-0.7	0.9	0.9
Retroperitoneal fat weight	0.0	0.1	0.2	0.3	0.4	-0.4	0.1	-0.4	-0.3
Reaction time number correct	4.2	8.0	9.3	3.1	2.7	-2.7	2.9	-2.7	-2.8
Reaction time mean minus median	0.0	0.1	0.2	-0.4	-0.3	0.3	-0.3	0.4	0.3
Reaction time mean minus median AUC	0.1	0.2	0.2	0.4	0.4	-0.4	0.5	-0.3	-0.4
Reaction time num false alarms	4.3	6.1	7.2	2.7	2.4	-2.4	2.5	-2.4	-2.5
Reaction time num false alarms AUC	3.4	5.2	6.2	2.5	2.2	-2.2	2.3	-2.3	-2.3
Reaction time trials correct on left	4.2	8.0	9.3	3.1	2.7	-2.7	2.9	-2.7	-2.8
Reaction time trials on left	4.2	8.0	9.3	3.0	2.7	-2.7	2.9	-2.7	-2.8
Reaction time mean	1.1	1.8	1.9	-1.4	-1.4	1.4	-1.1	1.4	1.3
Reaction time mean AUC	0.8	1.3	1.5	-1.2	-1.2	1.2	-1.0	1.2	1.1
Median of all reaction times	1.5	2.2	2.3	-1.5	-1.5	1.5	-1.3	1.5	1.5
Reaction time omissions	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	0.1	-0.0
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	-0.4	-0.4
Reaction time premature initiation rate	0.5	0.7	0.7	-0.8	-0.9	0.9	-0.8	0.8	0.8
Reaction time premature initiations	0.2	0.4	0.5	0.7	0.5	-0.5	0.7	-0.6	-0.7
Std. dev. reaction times	0.2	0.3	0.4	-0.6	-0.5	0.5	-0.5	0.6	0.5
Reaction time trials completed	4.2	8.0	9.3	3.0	2.7	-2.7	2.9	-2.7	-2.8
Reaction time trials AUC	5.1	9.7	11.3	3.4	3.0	-3.0	3.2	-3.0	-3.0
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.6	-0.4	0.4	-0.5	0.5	0.5
Run reversals in cocaine runway, males	0.5	0.5	0.5	0.7	0.7	-0.7	0.7	-0.7	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.4	0.2	-0.2	0.5	-0.1	-0.3
Latency to leave start box in cocaine runway, F	0.7	0.8	0.9	0.9	0.9	-0.9	0.9	-0.7	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.1	0.4	0.3
Std. dev. time between licks in bursts	0.0	0.1	0.2	0.3	-0.0	0.0	0.5	0.1	-0.1
Total sessions with >9 infusions	3.9	4.8	5.4	2.3	2.2	-2.2	2.1	-2.2	-2.2
Short access day 1 total inactive lever presses	0.4	0.6	0.7	0.8	0.7	-0.7	0.7	-0.8	-0.8
Short access day 10 total inactive lever presses	0.6	1.5	1.7	-1.3	-1.2	1.2	-1.2	1.2	1.2
Short access day 1 total infusions	2.0	2.6	3.0	1.7	1.6	-1.6	1.6	-1.7	-1.6
Short access day 10 total infusions	3.7	4.7	5.4	2.3	2.2	-2.2	2.1	-2.1	-2.1
Short access total infusions	2.2	2.9	3.3	1.8	1.7	-1.7	1.6	-1.7	-1.7
Short access day 1 locomotion	3.4	4.2	4.7	2.2	2.0	-2.0	2.0	-2.0	-2.0
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	-0.1
Short access total locomotion	0.8	1.0	1.0	1.0	1.0	-1.0	1.0	-0.9	-1.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	-0.1	-0.2
Compulsive drug intake	0.3	0.3	0.4	0.5	0.6	-0.6	0.6	-0.4	-0.5
One hour access (shock baseline)	0.9	1.3	1.5	1.2	1.1	-1.1	1.1	-1.1	-1.1
Social response proportion	1.1	1.2	1.6	1.2	1.0	-1.0	1.3	-1.0	-1.1
Social responses	0.9	1.1	1.4	1.2	1.1	-1.1	1.0	-1.0	-1.1
Social time	3.4	4.6	5.3	-2.3	-2.1	2.1	-2.1	2.3	2.1
Soleus weight	0.1	0.4	0.5	0.7	0.5	-0.5	0.6	-0.6	-0.6
Bone: stiffness	0.9	1.4	1.6	1.2	1.2	-1.2	1.2	-1.2	-1.1
Tibialis anterior weight	3.4	11.4	13.6	3.7	3.2	-3.2	3.3	-3.4	-3.4
Time to tail flick, vehicle, before self-admin	3.0	3.2	3.6	1.9	1.8	-1.8	1.7	-1.8	-1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	-0.1	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	0.5	-0.7	-0.7	0.7	-0.7	0.6	0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.5	-0.4	0.4	-0.5	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	0.4	0.3
Delta time to tail flick, test, before/after SA	0.9	0.9	1.0	1.0	1.0	-1.0	0.9	-0.8	-0.9
Tibia length	0.2	0.6	0.8	0.7	0.8	-0.8	0.9	-0.6	-0.7
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.0	0.0	0.2	0.1	0.0
Ambulatory time after self-admin	0.4	0.5	0.5	-0.7	-0.7	0.7	-0.6	0.7	0.7
Bone: tissue strength	0.9	1.0	1.1	-1.0	-0.9	0.9	-1.0	1.0	0.9
Total heroin consumption	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1	0.1
Bone: trabecular number	0.0	0.1	0.2	-0.1	-0.3	0.3	0.1	0.4	0.2
Bone: trabecular spacing	0.0	0.0	0.1	0.0	0.2	-0.2	-0.1	-0.4	-0.2
Bone: trabecular thickness	1.5	1.9	2.4	1.6	1.3	-1.3	1.5	-1.1	-1.3
Bone: trabecular tissue density	0.3	0.5	0.6	0.7	0.7	-0.7	0.6	-0.6	-0.7
Water consumed over 24 hours	0.1	0.2	0.2	-0.3	-0.5	0.5	-0.2	0.5	0.4
Number of responses in last shaping day	3.1	3.4	3.8	1.9	1.9	-1.9	1.8	-1.9	-1.8