Fndc3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Fndc3b	0.38	0.21	1.7e-15	0.1	0.1	0.1	0.11	2.1e-11	2.4e-11	9.6e-12	9.4e-12
2	IC	gene expression	Fndc3b	0.09	0.06	3.0e-03	0.06	0.05	0.04	0.04	1.8e-03	4.9e-03	1.0e-02	7.6e-03
3	Adipose	gene expression	Fndc3b	0.15	0.08	5.8e-12	0.07	0.1	0.09	0.1	1.1e-08	6.1e-11	1.6e-10	7.1e-11
4	PL	gene expression	Fndc3b	0.09	0.05	5.5e-11	0.1	0.1	0.1	0.1	2.9e-11	2.2e-11	3.9e-11	2.7e-11
5	NAcc	gene expression	Fndc3b	0.04	0.02	3.4e-06	0.03	0.04	0.03	0.03	6.6e-06	8.9e-07	1.9e-05	7.1e-06
6	Brain	gene expression	Fndc3b	0.22	0.16	5.6e-16	0.13	0.16	0.15	0.16	2.5e-12	8.3e-15	7.3e-14	5.5e-15
7	Adipose	mRNA stability	Fndc3b	0.02	0.02	5.5e-03	0.01	0.01	0	0.01	1.8e-02	9.5e-03	9.2e-02	2.3e-02
8	PL	mRNA stability	Fndc3b	0.03	0.02	5.7e-03	0	0.01	0.01	0.01	1.8e-01	8.5e-03	3.0e-02	4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.4	0.7	3.5	0.8	0.8	1.9	-0.5	-0.3	-0.0	-0.1	0.2
Area under the delay curve	0.4	0.7	2.4	0.0	0.0	1.5	0.5	0.7	0.6	-1.0	0.9
BMI with tail	0.3	0.9	1.8	0.8	0.8	-0.5	-0.9	-1.0	-0.9	1.1	-1.3
BMI without tail	0.0	0.1	0.7	-0.0	-0.0	0.8	0.1	0.2	0.3	-0.3	0.1
Body weight	0.2	0.9	1.6	0.6	0.7	-1.0	-0.9	-1.0	-1.0	1.2	-1.3
Weight adjusted by age	0.3	0.9	3.6	-1.1	-1.1	-1.9	0.8	0.6	0.3	-0.2	0.1
Bone surface	0.3	0.5	0.7	0.7	0.7	-0.4	-0.7	-0.8	-0.7	0.8	-0.8
Bone volume	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	0.2	0.3	-0.3	0.2
Breakpoint value in progressive ratio session	0.5	0.9	1.7	-0.4	-0.4	1.3	0.7	0.9	1.0	-1.1	1.3
Number of licking bursts	0.2	0.5	0.8	-0.9	-0.9	-0.6	0.7	0.7	0.6	-0.5	0.4
Context. condit. distance diff. score	2.3	2.8	4.7	2.2	2.1	2.0	-1.8	-1.6	-1.3	1.1	-0.9
Locomotion velocity, session 1	1.9	2.2	4.4	0.8	0.9	-2.1	-1.1	-1.3	-1.6	1.7	-1.8
Locomotion distance, session 1	1.6	2.1	3.0	1.0	1.0	-1.5	-1.3	-1.5	-1.5	1.7	-1.7
Locomotion velocity, session 2	0.4	0.5	2.9	-0.2	-0.2	-1.7	-0.1	-0.3	-0.3	0.6	-0.7
Locomotion distance, session 2	0.6	0.9	2.5	0.3	0.3	-1.6	-0.6	-0.8	-0.8	1.1	-1.2
Locomotion velocity, session 3	0.0	0.0	0.1	0.1	0.1	-0.3	-0.1	-0.1	-0.1	0.2	-0.2
Locomotion distance, session 3	0.3	0.4	0.6	0.3	0.3	-0.8	-0.5	-0.6	-0.6	0.7	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	0.3	-0.5	-0.3	-0.3	-0.4	0.4	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	0.7	0.5	0.5	0.8	-0.3	-0.2	-0.2	0.0	0.0
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.2	-0.2	0.3	-0.2
Locomotion distance, session 7	1.1	1.4	2.0	-1.0	-1.1	0.5	1.2	1.3	1.3	-1.3	1.4
Stereotopy head waving bouts, day 7	0.9	1.0	1.3	1.1	1.1	-0.2	-1.1	-1.2	-1.0	1.1	-1.1
Stereotopy head waving duration, day 7	1.7	2.2	2.8	1.7	1.7	0.3	-1.6	-1.6	-1.5	1.5	-1.5
Locomotion velocity, session 8	1.0	1.2	1.6	1.3	1.3	0.0	-1.2	-1.2	-1.0	1.2	-1.1
Locomotion distance, session 8	1.0	1.5	1.9	1.4	1.4	0.2	-1.4	-1.4	-1.1	1.2	-1.2
Degree of sensitization distance	2.4	2.6	3.2	-1.6	-1.6	0.4	1.7	1.8	1.7	-1.8	1.8
Degree of sensitization stereotypy	1.4	1.5	2.2	1.5	1.5	0.7	-1.4	-1.4	-1.1	1.2	-1.1
Conditioned locomotion	1.3	1.5	2.1	-0.8	-0.9	1.4	1.1	1.2	1.4	-1.4	1.4
Cocaine response after cond. corrected	1.2	1.8	2.5	-1.2	-1.2	0.6	1.4	1.4	1.4	-1.6	1.6
Cocaine response after cond. not corrected	0.8	1.1	1.5	-1.1	-1.1	-0.1	1.2	1.2	1.1	-1.2	1.2
Cocaine response before conditioning	1.4	1.6	2.2	1.2	1.2	-0.7	-1.3	-1.4	-1.5	1.4	-1.4
Saline control response	0.1	0.1	0.2	0.4	0.4	-0.0	-0.3	-0.3	-0.4	0.4	-0.3
Bone: connectivity density	0.9	1.5	2.4	1.5	1.5	1.2	-1.3	-1.2	-1.0	0.9	-0.8
Bone: cortical apparent density	0.1	0.2	0.8	-0.0	-0.0	0.9	0.3	0.3	0.5	-0.5	0.5
Bone: cortical area	0.2	0.3	0.4	0.5	0.5	0.0	-0.6	-0.6	-0.5	0.6	-0.6
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.2	0.4	0.2	0.3	0.3	-0.4	0.5
Bone: cortical porosity	0.1	0.2	0.3	-0.2	-0.2	0.6	0.3	0.4	0.3	-0.5	0.5
Bone: cortical thickness	0.2	0.3	1.0	0.6	0.6	1.0	-0.5	-0.4	-0.2	0.2	-0.2
Bone: cortical thickness	0.3	0.3	0.5	0.6	0.6	0.1	-0.6	-0.6	-0.5	0.6	-0.7
Bone: cortical tissue density	0.2	0.3	0.9	-0.1	-0.1	1.0	0.3	0.4	0.5	-0.6	0.6
Condit. Reinf. active minus inactive responses	2.0	2.3	3.7	-1.9	-1.9	-1.3	1.7	1.6	1.4	-1.1	1.0
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.9	-2.0	-2.0	-0.9	1.9	1.8	1.6	-1.4	1.4
Condit. Reinf. active responses	1.7	2.2	3.3	-1.8	-1.8	-1.0	1.7	1.5	1.4	-1.2	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	-0.3	-0.0	0.2	0.2	0.2	-0.2	0.2
Incentive salience index mean	2.7	3.5	5.3	-2.3	-2.3	-1.3	2.1	2.0	1.7	-1.5	1.4
Condit. Reinf. lever presses	1.2	1.8	2.6	-1.6	-1.6	-0.6	1.5	1.5	1.3	-1.2	1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	1.0	0.0	0.0	-1.0	-0.2	-0.3	-0.4	0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.4	0.3	0.3	-0.2	0.2
Condit. Reinf. active responses	1.0	1.4	6.5	0.0	0.1	-2.5	-0.5	-0.7	-1.0	1.3	-1.4
Condit. Reinf. inactive responses	1.3	2.0	7.2	0.3	0.4	-2.7	-0.8	-1.0	-1.3	1.6	-1.6
Condit. Reinf. lever presses	0.6	0.8	1.2	1.0	1.0	-0.3	-1.0	-0.9	-1.1	1.0	-0.8
Condit. Reinf. lever reinforcers received	0.9	1.3	4.9	0.2	0.3	-2.2	-0.6	-0.8	-1.0	1.3	-1.3
Conditioned reinforcement - actives	0.4	1.6	2.8	-1.7	-1.7	-0.8	1.3	1.3	1.1	-1.0	1.0
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.6	-0.6	-0.4	0.4	0.4	0.2	-0.3	0.4
Conditioned locomotion	0.3	0.5	0.8	-0.9	-0.9	-0.7	0.7	0.7	0.4	-0.5	0.5
Patch foraging indifference point 0 sec	0.5	1.4	2.4	1.5	1.5	0.8	-1.2	-1.2	-1.1	1.0	-0.9
Patch foraging indifference point AUC	5.5	13.0	15.8	3.6	3.7	-0.8	-3.9	-4.0	-3.9	3.9	-3.9
Delay disc. indifference point, 0s delay	0.7	0.8	1.7	0.3	0.3	-1.3	-0.7	-0.8	-1.0	1.1	-1.2
Delay disc. indifference point, 16s delay	1.3	1.8	7.3	0.2	0.2	2.7	0.6	0.9	1.0	-1.5	1.6
Delay disc. indifference point, 2s delay	0.6	0.6	1.0	-0.4	-0.5	1.0	0.7	0.8	0.8	-1.0	0.9
Delay disc. indifference point, 24s delay	0.5	0.7	3.1	1.0	1.0	1.8	-0.6	-0.5	-0.3	-0.0	0.0
Delay disc. indifference point, 4s delay	0.4	0.4	1.4	-0.1	-0.2	1.2	0.5	0.6	0.6	-0.8	0.7
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	0.1	0.1	0.4	0.2	0.3	0.1	-0.4	0.3
Indifference point function ln k	3.0	9.2	11.2	-3.1	-3.2	0.4	3.3	3.3	3.2	-3.3	3.3
Indifference point function log k	3.0	9.2	11.2	-3.1	-3.2	0.4	3.3	3.3	3.2	-3.3	3.3
Patch foraging total patch changes 0 sec	0.4	1.3	2.2	1.5	1.5	0.9	-1.1	-1.1	-1.0	0.8	-0.8
Patch foraging total patch changes 12 sec	7.7	10.4	12.2	3.5	3.5	-0.2	-3.5	-3.5	-3.4	3.4	-3.3
Patch foraging total patch changes 18 sec	2.0	4.8	6.1	2.2	2.3	-0.4	-2.3	-2.3	-2.3	2.4	-2.5
Patch foraging total patch changes 24 sec	4.2	14.3	17.4	4.1	4.2	0.1	-4.1	-4.1	-4.0	3.9	-3.8
Patch foraging total patch changes 6 sec	5.1	8.6	11.5	3.4	3.4	0.9	-3.3	-3.2	-3.0	2.8	-2.7
Patch foraging time to switch 0 sec	1.7	6.6	8.4	-2.6	-2.6	0.4	2.8	2.8	2.9	-2.8	2.7
Patch foraging water rate 0 sec	0.7	2.8	3.7	1.9	1.9	0.6	-1.8	-1.8	-1.7	1.6	-1.5
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.3	-0.3	0.1	0.3	0.2	0.3	-0.2	0.2
Patch foraging water rate 18 sec	0.1	0.3	1.2	-0.3	-0.3	-1.1	-0.1	-0.2	-0.3	0.5	-0.6
Patch foraging water rate 24 sec	1.2	1.7	2.3	1.5	1.5	1.2	-1.5	-1.4	-1.1	1.1	-0.9
Patch foraging water rate 6 sec	0.1	0.2	0.6	-0.3	-0.3	0.8	0.3	0.3	0.5	-0.5	0.5
Seeking ratio, delayed vs. immediate footshock	1.3	1.9	2.9	1.7	1.7	0.8	-1.6	-1.5	-1.3	1.1	-1.0
Distance traveled before self-admin	0.7	1.6	2.2	1.2	1.2	-0.5	-1.4	-1.5	-1.2	1.5	-1.5
Distance traveled after self-admin	0.5	0.9	1.3	1.0	1.1	-0.2	-1.1	-1.2	-0.9	1.0	-0.9
Extensor digitorum longus weight	0.1	0.3	1.8	0.1	0.1	1.3	0.1	0.2	0.4	-0.4	0.4
Bone: elastic displacement	0.2	0.3	0.5	0.7	0.7	0.7	-0.5	-0.4	-0.4	0.2	-0.1
Bone: elastic work	0.2	0.3	0.4	0.6	0.6	-0.3	-0.6	-0.6	-0.6	0.6	-0.6
Bone: endosteal estimation	0.3	0.7	4.2	-0.8	-0.8	-2.1	0.4	0.2	0.0	0.2	-0.2
Bone: endosteal perimeter	0.2	0.5	2.7	-0.7	-0.7	-1.6	0.4	0.2	0.0	0.0	-0.0
Epididymis fat weight	0.0	0.1	0.7	-0.2	-0.2	-0.8	0.0	-0.1	-0.1	0.3	-0.4
Delta time in closed arm before/after self-admin	1.9	1.8	3.3	1.8	1.8	1.5	-1.3	-1.2	-1.2	0.8	-0.7
Delta time in open arm before/after self-admin	0.6	0.7	1.7	-1.0	-1.0	-1.3	0.7	0.6	0.6	-0.4	0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	1.5	0.0	-0.0	1.2	0.1	0.3	0.4	-0.6	0.8
Delay discount exponential model param	0.5	0.7	2.7	-0.1	-0.0	-1.6	-0.5	-0.7	-0.6	1.0	-0.9
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	0.4	0.2	-0.3	-0.2	-0.4	0.2	-0.0
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.5	-0.5	0.5	0.6	0.7	0.6	-0.7	0.8
Bone: final force	0.2	0.4	0.7	0.3	0.3	-0.8	-0.6	-0.7	-0.6	0.8	-0.7
Bone: final moment	0.4	0.7	1.0	0.7	0.7	-0.6	-0.9	-0.9	-0.9	1.0	-0.9
Food consumed during 24 hour testing period	0.0	0.1	0.3	0.0	0.0	-0.6	-0.1	-0.1	-0.3	0.2	-0.2
Glucose	0.3	0.4	0.6	-0.8	-0.8	-0.6	0.8	0.7	0.6	-0.5	0.3
Heart weight	2.9	4.6	6.3	2.5	2.5	0.4	-2.4	-2.3	-2.2	2.1	-1.9
Delay discount hyperbolic model param	0.6	0.7	2.3	0.1	0.1	-1.5	-0.6	-0.8	-0.7	1.1	-1.0
Intermittent access intake day 1-15 change	0.1	0.3	0.7	-0.4	-0.4	0.7	0.5	0.4	0.8	-0.6	0.3
Intermittent access intake escalation	0.0	0.1	0.3	-0.2	-0.2	0.6	0.3	0.2	0.6	-0.3	0.1
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.0	-0.1	0.1	0.1	-0.2
Intermitt. access day 1 inactive lever presses	0.1	1.0	1.5	-0.8	-0.8	0.7	1.0	1.1	1.1	-1.2	1.2
Intermitt. access day 15 inactive lever presses	0.1	0.6	1.4	-1.1	-1.0	-1.2	0.7	0.6	0.5	-0.3	0.3
Intermitt. access escalation Index	0.3	1.0	1.4	1.0	1.1	0.1	-1.2	-1.1	-1.1	1.0	-0.9
Intermittent access day 1 total infusions	1.5	4.4	9.5	-2.8	-2.7	-3.1	2.1	1.8	1.4	-1.0	0.7
Intermittent access day 15 total infusions	0.3	0.8	2.5	-1.2	-1.1	-1.6	0.7	0.5	0.6	-0.0	-0.2
Intermittent access terminal intake (last 3 days)	1.3	2.3	5.9	-2.0	-2.0	-2.4	1.4	1.1	1.1	-0.4	0.1
Intermittent access total infusions	1.2	1.4	6.4	-1.4	-1.3	-2.5	0.7	0.5	0.3	0.1	-0.3
Intermittent access day 1 locomotion	1.4	2.6	5.2	-2.1	-2.1	-2.3	1.6	1.4	1.1	-0.8	0.6
Intermittent access day 15 total locomotion	0.3	1.0	1.2	-1.0	-1.1	-0.1	1.1	1.1	1.0	-1.0	1.0
Intermittent access total locomotion	1.4	1.7	2.9	-1.7	-1.7	-1.2	1.4	1.3	1.1	-0.9	0.8
Intermittent access standard deviation	0.3	1.5	1.8	-1.3	-1.3	-0.1	1.3	1.3	1.3	-1.2	1.2
Left kidney weight	0.1	0.7	1.3	0.5	0.5	-0.7	-0.8	-0.9	-0.8	1.0	-1.1
Right kidney weight	0.2	1.4	2.0	1.3	1.3	0.4	-1.4	-1.3	-1.2	1.2	-1.2
Cocaine induced anxiety	0.0	0.1	0.2	0.5	0.5	-0.3	-0.3	-0.4	-0.3	0.4	-0.3
Post-drug Anxiety	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.3	0.3	-0.2	0.2
Baseline Anxiety	0.0	0.0	0.1	-0.3	-0.3	-0.2	0.2	0.2	0.0	-0.1	0.0
Tail length	0.1	0.4	0.6	-0.6	-0.7	0.4	0.6	0.7	0.7	-0.8	0.8
Length with tail	0.1	0.4	2.3	-0.1	-0.1	-1.5	-0.3	-0.4	-0.6	0.6	-0.6
Length without tail	0.8	4.1	5.5	1.5	1.6	-1.9	-2.0	-2.1	-2.3	2.3	-2.2
Times rat made contact with spout	0.3	0.3	1.9	-0.6	-0.5	-1.4	0.2	0.1	-0.0	0.2	-0.1
Lifetime Intake	1.4	1.7	8.2	-1.5	-1.5	-2.9	0.8	0.6	0.3	0.1	-0.3
Liver weight, left	1.2	2.0	11.2	-1.4	-1.3	-3.4	0.6	0.2	-0.0	0.5	-0.8
Liver weight, right	0.2	0.3	1.9	-0.4	-0.4	-1.4	-0.0	-0.1	-0.2	0.4	-0.3
Locomotor activity	2.8	4.4	6.7	1.4	1.4	-2.4	-1.8	-2.0	-2.3	2.5	-2.6
Locomotor testing distance	1.9	4.6	6.4	1.7	1.7	-2.1	-1.9	-2.1	-2.4	2.5	-2.5
Locomotor testing rearing	1.6	5.9	8.4	2.4	2.4	-1.1	-2.5	-2.5	-2.9	2.6	-2.6
Locomotion in novel chamber	1.4	1.9	2.9	1.1	1.1	-1.0	-1.3	-1.4	-1.5	1.7	-1.7
Locomotion in novel chamber post-restriction	0.2	0.7	0.9	0.7	0.7	-0.5	-0.9	-0.9	-0.9	0.9	-0.9
Fecal boli incidents, locomotor time 1	0.1	0.4	1.3	0.1	0.1	-1.1	-0.3	-0.5	-0.5	0.7	-0.9
Change in fecal boli incidents, locomotor task	2.7	2.8	4.0	2.0	2.0	1.0	-1.9	-1.8	-1.7	1.5	-1.3
Time >=10cm from walls, locomotor time 1	0.5	0.6	0.9	0.7	0.7	-0.1	-0.9	-1.0	-0.8	0.9	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	-0.0	0.4	0.4	0.5	-0.4	0.4
Total resting periods, locomotor time 1	0.2	0.3	0.4	-0.6	-0.6	-0.2	0.5	0.5	0.6	-0.4	0.4
Rest time, locomotor task time 1	0.2	0.3	0.9	-0.1	-0.1	-0.9	-0.3	-0.5	-0.4	0.7	-0.8
Distance moved, locomotor task time 1	0.3	0.8	1.5	1.2	1.2	0.8	-1.0	-0.8	-0.9	0.6	-0.4
Vertical activity count, locomotor time 1	0.0	0.1	0.5	0.2	0.2	0.7	-0.1	0.1	0.0	-0.2	0.3
Time >=10cm from walls, locomotor time 2	0.9	2.4	3.9	1.1	1.2	-1.4	-1.5	-1.6	-1.7	1.9	-2.0
Bouts of movement, locomotor time 2	0.0	0.1	0.1	0.3	0.3	-0.1	-0.3	-0.2	-0.3	0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.4	0.4	-0.1	-0.4	-0.3	-0.4	0.4	-0.3
Rest time, locomotor task time 2	0.7	1.2	1.6	1.2	1.2	0.4	-1.3	-1.3	-1.1	1.1	-1.0
Distance moved, locomotor task time 2	0.2	0.3	0.5	-0.6	-0.6	-0.2	0.7	0.7	0.7	-0.5	0.5
Vertical activity count, locomotor time 2	0.9	2.0	2.7	-1.7	-1.7	-0.5	1.6	1.5	1.6	-1.3	1.1
Light reinforcement 1	0.4	2.0	2.6	1.3	1.3	-0.5	-1.5	-1.6	-1.4	1.6	-1.6
Light reinforcement 2	0.6	1.3	1.7	1.2	1.3	0.2	-1.3	-1.3	-1.0	1.2	-1.1
Bone: marrow area	0.3	0.6	3.6	-0.8	-0.8	-1.9	0.4	0.2	0.1	0.2	-0.2
Bone: maximum diameter	0.3	0.5	0.7	0.6	0.6	-0.5	-0.8	-0.8	-0.9	0.8	-0.8
Bone: maximum force	0.2	0.4	1.6	-0.0	0.0	-1.3	-0.3	-0.4	-0.4	0.7	-0.7
Bone: maximum moment	0.4	0.7	1.4	0.4	0.4	-1.2	-0.7	-0.8	-0.8	1.1	-1.0
Mean time between licks in bursts	1.3	7.6	10.0	-3.1	-3.2	-0.3	3.0	2.9	3.0	-2.7	2.6
Mean num. licks in bursts	0.1	0.2	0.4	0.6	0.6	0.2	-0.6	-0.6	-0.5	0.4	-0.3
Cd content in liver	0.6	0.6	2.9	-0.9	-0.9	-1.7	0.7	0.5	0.3	-0.0	-0.1
Co content in liver	0.1	0.1	0.7	-0.2	-0.2	-0.8	0.1	-0.0	-0.1	0.1	-0.1
Cu content in liver	2.4	2.9	4.0	1.1	1.2	-1.8	-1.5	-1.7	-1.9	2.0	-2.0
Fe content in liver	1.2	1.5	2.2	0.9	0.9	-1.2	-1.1	-1.2	-1.3	1.4	-1.5
K content in liver	1.9	1.9	2.4	1.5	1.5	-0.3	-1.5	-1.5	-1.6	1.4	-1.3
Mg content in liver	2.4	2.6	3.3	1.7	1.7	-0.3	-1.8	-1.8	-1.8	1.7	-1.6
Mn content in liver	0.0	0.0	0.2	0.1	0.0	0.4	0.0	0.1	0.1	-0.2	0.3
Na content in liver	1.0	1.1	1.4	1.1	1.1	-0.2	-1.2	-1.2	-1.2	1.1	-1.1
Rb content in liver	0.3	0.4	2.3	0.4	0.4	1.5	-0.2	-0.0	0.2	-0.3	0.4
Se content in liver	0.8	0.9	3.4	0.2	0.2	-1.8	-0.5	-0.7	-0.8	1.1	-1.2
Sr content in liver	0.2	0.2	0.2	0.5	0.5	0.1	-0.5	-0.5	-0.5	0.4	-0.4
Zn content in liver	0.3	0.4	0.6	0.4	0.4	-0.8	-0.5	-0.6	-0.7	0.7	-0.8
Bone: minimum diameter	0.5	0.9	1.6	-1.3	-1.2	-1.2	1.0	0.9	0.7	-0.6	0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	-0.2	0.3	0.2	0.2	0.3	-0.2	0.3
Time in novel zone, hab. session 1	0.9	1.0	2.1	1.3	1.3	1.4	-1.0	-0.9	-0.7	0.5	-0.5
Total zone transitions, hab. session 1	0.2	0.2	1.0	0.6	0.6	1.0	-0.3	-0.3	-0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.4	0.5	2.4	0.8	0.8	1.5	-0.5	-0.4	-0.1	0.1	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	1.4	0.5	0.5	1.2	-0.2	-0.1	0.0	-0.1	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4	0.4	0.2	-0.3	0.4
Time in novel zone, hab. session 2	3.5	3.8	5.5	2.3	2.3	1.0	-2.2	-2.1	-1.8	1.8	-1.7
Total zone transitions, hab. session 2	2.3	2.9	3.8	1.5	1.6	-1.1	-1.7	-1.8	-1.8	2.0	-1.9
Total locomotion distance, hab. session 2	1.5	2.0	2.6	1.4	1.4	-0.4	-1.5	-1.5	-1.5	1.6	-1.6
Locomotion velocity, hab. session 2	0.9	1.2	1.6	1.0	1.0	-0.4	-1.1	-1.2	-1.1	1.2	-1.3
Novel to familiar place preference ratio	3.0	3.9	7.0	2.5	2.5	2.6	-2.0	-1.8	-1.5	1.1	-1.0
Novelty place preference	3.9	4.9	8.1	2.8	2.8	2.8	-2.3	-2.1	-1.7	1.3	-1.2
Time in novel zone, NPP test	5.3	6.5	10.5	3.2	3.2	2.9	-2.7	-2.5	-2.1	1.7	-1.5
Total zone transitions, NPP test	0.9	1.4	3.0	0.6	0.6	-1.7	-0.8	-1.0	-1.1	1.4	-1.5
Total locomotion distance, NPP test	0.4	0.6	1.4	0.3	0.4	-1.2	-0.5	-0.7	-0.7	0.9	-1.1
Locomotion velocity, NPP test	0.3	0.5	1.9	0.1	0.1	-1.4	-0.2	-0.4	-0.5	0.7	-0.9
Intraocular pressure	0.0	0.0	0.1	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.1	-0.1	0.1	-0.1
Delta ambulatory time before/after self-admin	0.2	0.4	1.0	-0.2	-0.2	1.0	0.5	0.6	0.7	-0.8	0.9
Parametrial fat weight	1.7	3.9	4.6	-2.1	-2.1	0.0	2.2	2.2	2.0	-2.1	2.1
Pavlov. Cond. lever latency	1.9	2.4	3.8	1.9	1.9	1.3	-1.7	-1.6	-1.4	1.2	-1.1
Pavlov. Cond. magazine entry latency	2.2	2.8	3.7	-1.9	-1.9	-0.4	1.9	1.8	1.7	-1.6	1.5
Pavlov. Cond. change in total contacts	2.8	3.0	3.9	-2.0	-2.0	-0.5	2.0	1.9	1.8	-1.7	1.5
Pavlov. Cond. index score	2.1	2.7	4.2	-2.0	-2.0	-1.2	1.9	1.7	1.5	-1.3	1.2
Pavlov. Cond. latency score	2.3	2.9	4.6	-2.1	-2.1	-1.3	1.9	1.8	1.6	-1.4	1.2
Pavlov. Cond. lever contacts	2.9	3.5	5.2	-2.3	-2.3	-1.1	2.1	2.0	1.8	-1.6	1.5
Pavlov. Cond. magazine entry number	2.2	2.8	3.6	1.9	1.9	0.2	-1.9	-1.8	-1.7	1.6	-1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.6	0.4	0.4	-1.6	-0.7	-0.9	-1.1	1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.2	4.7	-2.2	-2.2	-1.0	2.0	1.9	1.7	-1.6	1.4
Pavlov. Cond. response bias	1.8	2.2	3.1	-1.8	-1.8	-0.6	1.7	1.6	1.5	-1.4	1.3
Pavlov. Cond. lever latency	1.1	1.5	2.1	-1.5	-1.5	-0.3	1.4	1.3	1.3	-1.2	1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	0.0	-0.4	-0.2	-0.2	-0.2	0.2	-0.2
Pavlov. Cond. change in total contacts	0.4	0.9	1.7	0.6	0.6	-1.3	-0.8	-0.9	-1.0	1.1	-1.0
Pavlov. Cond. index score	0.2	0.3	0.5	0.6	0.6	-0.3	-0.7	-0.6	-0.7	0.7	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	0.4	0.4	-0.3	-0.4	-0.4	-0.5	0.5	-0.3
Pavlov. Cond. lever contacts	1.0	1.5	2.2	1.5	1.5	0.5	-1.4	-1.3	-1.3	1.1	-0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4	0.4	0.4	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.5	0.9	0.5	0.5	-0.8	-0.6	-0.7	-0.8	0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.5	0.6	-0.5	-0.7	-0.7	-0.7	0.7	-0.6
Pavlov. Cond. response bias	0.6	0.8	1.0	1.0	1.0	0.0	-1.0	-0.9	-1.0	0.9	-0.7
Time in closed arm before self-admin	1.2	2.0	2.6	-1.3	-1.4	0.6	1.5	1.6	1.5	-1.6	1.6
Time in closed arm after self-admin	0.3	0.3	1.7	0.6	0.6	1.3	-0.2	-0.0	-0.2	-0.2	0.4
Time in open arm before self-admin	0.9	1.1	1.7	1.3	1.3	1.0	-1.2	-1.0	-0.9	0.7	-0.6
Time in open arm after self-admin	0.9	1.0	1.5	0.9	0.9	-0.4	-1.1	-1.2	-1.0	1.1	-1.1
Bone: periosteal estimation	0.1	0.3	1.4	-0.6	-0.6	-1.2	0.3	0.2	0.1	0.0	-0.1
Bone: periosteal perimeter	0.1	0.2	0.4	0.2	0.2	-0.7	-0.4	-0.4	-0.5	0.5	-0.4
Bone: post-yield work	0.3	0.6	2.7	-0.9	-0.9	-1.6	0.5	0.4	0.3	0.0	-0.2
Progressive ratio test 1 active lever presses	0.5	0.9	4.9	-0.5	-0.4	-2.2	-0.1	-0.3	-0.5	0.8	-0.9
Progressive ratio test 1 breakpoint	0.5	0.9	4.9	-0.5	-0.4	-2.2	-0.1	-0.3	-0.5	0.8	-0.9
Progressive ratio test 1 inactive lever presses	0.4	0.9	1.4	-1.2	-1.2	-0.8	1.1	1.0	0.8	-0.8	0.8
Progressive ratio test 2 active lever presses	1.1	1.6	7.1	-0.3	-0.2	-2.7	-0.4	-0.7	-0.9	1.3	-1.5
Progressive ratio test 2 breakpoint	1.1	1.4	6.5	-0.2	-0.2	-2.5	-0.4	-0.7	-0.9	1.2	-1.4
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.8	-0.8	-0.8	-1.3	0.4	0.3	0.1	0.0	-0.1
Incentive Sensitization - Responses	0.3	0.9	3.5	-1.2	-1.1	-1.9	0.7	0.5	0.4	-0.0	-0.1
Incentive Sensitization - Breakpoint	0.4	0.9	3.3	-1.2	-1.2	-1.8	0.7	0.5	0.4	-0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.0	-0.8	-0.8	0.2	0.8	0.8	0.8	-0.9	1.0
Progressive ratio	0.8	2.5	3.4	1.8	1.8	0.5	-1.7	-1.7	-1.6	1.5	-1.5
Food seeking constrained by brief footshock	2.0	2.5	4.1	-0.8	-0.9	2.0	1.3	1.6	1.6	-1.9	2.0
Seeking ratio, punishment vs. effort	1.6	3.5	4.9	-1.7	-1.7	0.9	1.9	2.0	2.0	-2.1	2.2
Retroperitoneal fat weight	0.0	0.2	0.8	-0.2	-0.2	-0.9	0.1	-0.0	-0.1	0.3	-0.5
Reaction time number correct	0.1	0.4	1.7	-0.7	-0.7	-1.3	0.3	0.1	-0.1	0.2	-0.3
Reaction time mean minus median	0.7	4.7	6.2	-2.2	-2.2	0.5	2.4	2.4	2.5	-2.3	2.1
Reaction time mean minus median AUC	0.3	1.9	2.7	-1.3	-1.3	0.6	1.5	1.5	1.6	-1.5	1.4
Reaction time num false alarms	1.5	2.6	3.6	1.7	1.7	-0.3	-1.7	-1.7	-1.9	1.7	-1.6
Reaction time num false alarms AUC	0.8	1.8	2.7	1.3	1.3	-0.5	-1.3	-1.3	-1.7	1.4	-1.4
Reaction time trials correct on left	0.1	0.4	1.7	-0.7	-0.7	-1.3	0.3	0.1	-0.1	0.2	-0.3
Reaction time trials on left	0.1	0.4	1.8	-0.8	-0.8	-1.3	0.4	0.2	0.1	0.1	-0.2
Reaction time mean	3.1	6.8	8.7	-2.8	-2.8	-0.3	2.9	2.9	2.9	-2.6	2.5
Reaction time mean AUC	2.7	6.4	8.1	-2.7	-2.7	-0.1	2.8	2.8	2.8	-2.6	2.4
Median of all reaction times	3.9	6.1	7.7	-2.7	-2.7	-0.3	2.8	2.7	2.7	-2.5	2.4
Reaction time omissions	3.8	6.2	7.8	-2.8	-2.8	-0.1	2.8	2.7	2.7	-2.5	2.3
Reaction time false alarm rate	1.4	2.0	2.9	1.7	1.7	0.3	-1.5	-1.4	-1.6	1.3	-1.2
Reaction time premature initiation rate	0.2	0.3	0.5	0.6	0.6	-0.1	-0.6	-0.6	-0.7	0.5	-0.4
Reaction time premature initiations	0.1	0.3	0.8	0.1	0.2	-0.9	-0.4	-0.5	-0.7	0.6	-0.6
Std. dev. reaction times	1.6	5.3	7.0	-2.3	-2.4	0.4	2.5	2.5	2.6	-2.4	2.3
Reaction time trials completed	0.1	0.4	1.8	-0.8	-0.8	-1.3	0.4	0.2	0.1	0.1	-0.2
Reaction time trials AUC	0.1	0.4	1.6	-0.9	-0.8	-1.3	0.4	0.3	0.1	0.0	-0.1
Run reversals in cocaine runway, females	0.2	0.3	1.1	-0.1	-0.1	1.0	0.2	0.3	0.4	-0.5	0.6
Run reversals in cocaine runway, males	4.3	4.8	6.1	-2.5	-2.5	-0.2	2.4	2.3	2.4	-2.1	2.1
Latency to leave start box in cocaine runway	1.4	1.9	3.0	-1.2	-1.2	0.5	1.4	1.6	1.4	-1.6	1.7
Latency to leave start box in cocaine runway, F	0.1	0.2	0.2	-0.3	-0.3	-0.2	0.4	0.5	0.3	-0.4	0.5
Latency to leave start box in cocaine runway, M	4.5	4.3	6.3	-1.8	-1.9	0.9	2.2	2.3	2.2	-2.4	2.5
Std. dev. time between licks in bursts	0.3	0.6	1.0	-1.0	-1.0	-0.6	0.8	0.8	0.8	-0.5	0.4
Total sessions with >9 infusions	1.6	2.0	4.6	-1.8	-1.8	-2.1	1.4	1.2	0.9	-0.6	0.6
Short access day 1 total inactive lever presses	0.3	0.6	1.0	-1.0	-1.0	-0.7	0.8	0.8	0.6	-0.6	0.4
Short access day 10 total inactive lever presses	0.3	1.9	8.1	0.2	0.2	2.9	0.6	0.9	1.2	-1.4	1.5
Short access day 1 total infusions	1.2	2.4	7.3	-1.9	-1.9	-2.7	1.4	1.2	0.8	-0.5	0.4
Short access day 10 total infusions	1.0	1.7	4.3	-1.7	-1.6	-2.1	1.2	1.0	0.8	-0.5	0.3
Short access total infusions	2.0	2.8	10.2	-2.1	-2.1	-3.2	1.4	1.1	0.7	-0.3	0.1
Short access day 1 locomotion	0.2	0.3	0.8	0.2	0.2	-0.9	-0.5	-0.5	-0.7	0.6	-0.5
Short access day 10 total locomotion	0.8	3.4	4.2	-1.8	-1.8	0.7	2.0	2.1	2.1	-2.1	2.0
Short access total locomotion	0.3	0.4	1.5	-0.8	-0.8	-1.2	0.5	0.4	0.2	-0.1	0.1
One hour access (0.3 mA shock)	0.4	0.4	2.1	-0.4	-0.3	-1.4	-0.2	-0.4	-0.4	0.7	-0.7
Compulsive drug intake	0.1	0.2	0.4	-0.2	-0.2	0.6	0.3	0.4	0.4	-0.5	0.5
One hour access (shock baseline)	0.2	0.5	2.6	-0.4	-0.3	-1.6	-0.1	-0.2	-0.3	0.6	-0.6
Social response proportion	1.2	1.5	2.2	-1.4	-1.4	-0.3	1.5	1.4	1.4	-1.2	1.0
Social responses	0.1	0.1	0.4	0.3	0.3	0.6	-0.3	-0.3	-0.2	0.1	-0.2
Social time	1.1	1.7	3.8	-1.7	-1.6	-1.9	1.3	1.1	0.9	-0.6	0.5
Soleus weight	2.1	6.3	28.9	2.8	2.7	5.4	-2.0	-1.4	-0.7	0.2	-0.0
Bone: stiffness	0.2	0.4	1.9	-0.3	-0.3	-1.4	-0.1	-0.2	-0.2	0.5	-0.6
Tibialis anterior weight	0.1	0.5	0.6	0.8	0.8	0.6	-0.8	-0.7	-0.6	0.6	-0.6
Time to tail flick, vehicle, before self-admin	0.9	1.1	2.1	-1.4	-1.4	-1.2	1.2	0.9	0.9	-0.6	0.3
Time to tail flick, vehicle, after self-admin	0.2	0.3	2.1	-0.4	-0.4	-1.5	0.3	0.1	-0.1	0.3	-0.5
Time to tail flick, test, before self-admin	0.9	1.0	5.3	0.3	0.2	2.3	0.2	0.4	0.8	-0.9	0.9
Time to tail flick, test, after self-admin	1.4	1.4	7.4	1.3	1.3	2.7	-0.6	-0.3	-0.0	-0.2	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	0.0	0.0	-0.0	0.1
Delta time to tail flick, test, before/after SA	0.9	1.1	1.5	1.2	1.2	0.3	-1.1	-1.0	-1.1	1.0	-1.0
Tibia length	0.9	2.4	13.5	-0.6	-0.5	-3.7	-0.1	-0.5	-0.9	1.3	-1.4
Ambulatory time before self-admin	0.7	2.1	3.1	1.1	1.1	-1.2	-1.5	-1.7	-1.4	1.8	-1.7
Ambulatory time after self-admin	0.1	0.2	0.2	0.4	0.4	-0.2	-0.4	-0.5	-0.3	0.4	-0.4
Bone: tissue strength	0.0	0.0	0.2	0.1	0.1	-0.4	-0.1	-0.1	-0.2	0.2	-0.2
Total heroin consumption	0.3	0.4	2.0	0.6	0.6	1.4	-0.5	-0.3	-0.1	-0.1	0.3
Bone: trabecular number	1.1	2.0	6.8	1.7	1.7	2.6	-1.3	-1.1	-0.6	0.4	-0.4
Bone: trabecular spacing	1.1	1.6	9.3	-0.4	-0.3	-3.0	-0.1	-0.4	-0.8	1.0	-1.1
Bone: trabecular thickness	2.1	2.9	4.0	-1.3	-1.4	1.6	1.6	1.7	1.9	-2.0	2.0
Bone: trabecular tissue density	1.8	3.2	4.3	-2.0	-2.0	-0.5	2.1	2.0	1.8	-1.8	1.7
Water consumed over 24 hours	0.4	0.7	1.1	0.6	0.6	-0.8	-0.9	-0.9	-0.9	1.1	-0.9
Number of responses in last shaping day	0.5	0.6	1.2	0.5	0.5	-0.8	-0.7	-0.8	-0.7	1.0	-1.1