Hub : Genes

Fndc3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Fndc3b	0.02	0.02	5.5e-03	0.01	0.01	0.01	0.01	4.2e-02	1.4e-02	7.4e-03	2.9e-02
2	Liver	gene expression	Fndc3b	0.41	0.21	4.7e-15	0.09	0.1	0.11	0.1	1.8e-10	3.8e-11	6.6e-12	1.3e-11
3	NAcc	gene expression	Fndc3b	0.04	0.03	2.9e-04	0.03	0.04	0.03	0.03	9.9e-05	4.9e-05	3.2e-04	3.2e-04
4	PL	gene expression	Fndc3b	0.09	0.05	1.7e-10	0.1	0.1	0.09	0.1	6.7e-11	6.5e-11	2.2e-10	9.6e-11
5	Brain	gene expression	Fndc3b	0.19	0.12	7.2e-16	0.14	0.16	0.14	0.17	5.5e-13	6.9e-15	2.3e-13	1.9e-15
6	LHb	mRNA stability	Fndc3b	0.23	0.17	5.4e-03	0.1	0.12	0.12	0.1	2.5e-03	7.0e-04	9.9e-04	2.4e-03
7	Adipose	gene expression	Fndc3b	0.14	0.08	9.4e-12	0.07	0.1	0.1	0.1	1.6e-08	8.5e-11	8.5e-11	9.1e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.7	1.2	3.5	0.2	-1.3	-0.5	-0.5	-0.2	1.9	-1.7
Area under the delay curve	1.0	1.0	3.5	-0.7	-0.3	0.6	0.6	0.8	1.3	-1.9
BMI with tail	0.4	1.3	2.9	1.7	-1.1	-1.3	-1.3	-1.1	-0.2	-0.0
BMI without tail	0.2	0.4	0.9	0.4	-0.7	-0.4	-0.4	-0.1	0.8	-1.0
Body weight	1.0	4.4	6.8	2.6	-0.6	-2.0	-2.0	-2.3	-1.9	2.5
Weight adjusted by age	1.2	1.3	3.4	-0.4	1.5	0.8	0.8	0.4	-1.8	1.4
Bone surface	0.3	0.5	0.8	0.9	-0.5	-0.7	-0.7	-0.9	-0.3	0.6
Bone volume	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	0.1	0.1	-0.2
Breakpoint value in progressive ratio session	0.3	0.4	0.9	-0.6	-0.2	0.3	0.3	0.5	1.0	-0.9
Number of licking bursts	0.5	0.6	1.1	-0.5	1.0	0.8	0.8	0.6	-0.9	0.6
Context. condit. distance diff. score	2.9	3.5	6.2	1.4	-2.5	-1.9	-1.8	-1.3	2.3	-1.6
Locomotion velocity, session 1	2.1	2.3	4.2	1.7	-0.2	-1.2	-1.3	-1.5	-1.8	2.0
Locomotion distance, session 1	1.6	2.1	3.3	1.8	-0.6	-1.4	-1.4	-1.6	-1.3	1.6
Locomotion velocity, session 2	0.9	1.0	3.3	0.7	0.7	-0.2	-0.2	-0.4	-1.7	1.8
Locomotion distance, session 2	0.9	1.2	2.8	1.2	0.1	-0.8	-0.8	-1.0	-1.5	1.7
Locomotion velocity, session 3	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1	-0.2	-0.3	0.4
Locomotion distance, session 3	0.3	0.3	0.6	0.6	-0.1	-0.5	-0.5	-0.5	-0.6	0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.3	-0.4	-0.3	0.4
Stereotopy head waving duration, day 3	0.3	0.3	0.9	-0.1	-0.7	-0.2	-0.3	-0.1	0.9	-0.8
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	-0.1	-0.2	-0.2	-0.2	-0.1	0.5
Locomotion distance, session 7	0.9	1.1	1.9	-1.4	0.8	1.2	1.2	1.3	0.4	-0.5
Stereotopy head waving bouts, day 7	1.1	1.2	1.9	1.4	-1.2	-1.4	-1.3	-1.3	0.2	0.3
Stereotopy head waving duration, day 7	1.4	1.7	2.5	1.5	-1.6	-1.6	-1.5	-1.4	0.5	-0.1
Locomotion velocity, session 8	0.9	1.1	1.7	1.3	-1.1	-1.3	-1.3	-1.1	0.2	0.1
Locomotion distance, session 8	1.0	1.4	2.1	1.5	-1.3	-1.4	-1.4	-1.2	0.5	-0.1
Degree of sensitization distance	2.1	2.1	3.2	-1.8	1.3	1.8	1.8	1.7	0.1	-0.6
Degree of sensitization stereotypy	1.3	1.4	2.1	1.3	-1.5	-1.4	-1.4	-1.2	0.7	-0.3
Conditioned locomotion	1.1	1.3	2.3	-1.3	0.3	1.1	1.1	1.3	1.1	-1.5
Cocaine response after cond. corrected	1.2	1.3	2.5	-1.6	1.0	1.3	1.4	1.3	0.4	-0.5
Cocaine response after cond. not corrected	0.9	0.9	1.6	-1.3	1.1	1.1	1.1	1.0	-0.2	0.3
Cocaine response before conditioning	1.0	1.2	1.8	1.3	-0.8	-1.3	-1.3	-1.3	-0.4	0.9
Saline control response	0.1	0.1	0.3	0.5	-0.1	-0.3	-0.3	-0.4	-0.4	0.5
Bone: connectivity density	1.0	1.6	2.8	1.1	-1.7	-1.3	-1.3	-1.1	1.3	-0.9
Bone: cortical apparent density	0.2	0.3	0.8	-0.5	-0.2	0.3	0.3	0.5	0.7	-0.9
Bone: cortical area	0.3	0.4	0.6	0.7	-0.7	-0.8	-0.8	-0.8	0.1	-0.2
Bone: cortical porosity	0.1	0.1	0.1	-0.4	0.0	0.2	0.2	0.2	0.4	-0.3
Bone: cortical porosity	0.2	0.2	0.4	-0.5	-0.0	0.3	0.3	0.3	0.6	-0.7
Bone: cortical thickness	0.4	0.7	1.6	0.3	-1.1	-0.6	-0.5	-0.3	1.0	-1.3
Bone: cortical thickness	0.4	0.5	0.8	0.9	-0.7	-0.9	-0.8	-0.8	-0.1	0.1
Bone: cortical tissue density	0.3	0.4	0.9	-0.6	-0.2	0.3	0.4	0.5	0.8	-0.9
Condit. Reinf. active minus inactive responses	2.2	2.4	4.4	-1.4	2.1	1.6	1.6	1.3	-1.6	0.9
Condit. Reinf. active-inactive response ratio	2.4	2.6	4.1	-1.7	2.0	1.9	1.9	1.6	-1.2	0.4
Condit. Reinf. active responses	1.7	2.1	3.6	-1.5	1.9	1.6	1.6	1.3	-1.2	0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	0.2	0.2	0.2	0.2	-0.0	0.2
Incentive salience index mean	2.8	3.4	5.9	-1.8	2.4	2.0	2.0	1.7	-1.6	0.8
Condit. Reinf. lever presses	1.2	1.6	2.7	-1.3	1.6	1.5	1.5	1.2	-0.9	0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.3	0.4	0.3	-0.3	-0.3	-0.4	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.2	0.5	0.3	0.3	0.3	-0.7	0.5
Condit. Reinf. active responses	1.8	2.5	7.4	1.0	0.8	-0.5	-0.6	-1.0	-2.5	2.7
Condit. Reinf. inactive responses	2.4	3.0	8.8	1.4	0.6	-0.9	-0.9	-1.5	-2.5	3.0
Condit. Reinf. lever presses	0.6	0.9	1.5	1.0	-0.8	-1.1	-1.1	-1.2	0.0	0.5
Condit. Reinf. lever reinforcers received	1.5	2.1	6.0	1.1	0.5	-0.7	-0.7	-1.1	-2.2	2.5
Conditioned reinforcement - actives	1.9	1.9	3.1	-1.7	1.8	1.6	1.5	1.3	-0.5	0.5
Conditioned reinforcement - inactives	0.5	0.6	1.6	-1.3	0.6	0.7	0.7	0.7	0.6	-0.2
Conditioned locomotion	0.1	0.1	0.3	-0.6	0.5	0.4	0.4	0.2	-0.1	0.1
Patch foraging indifference point 0 sec	0.8	1.2	1.9	1.2	-1.4	-1.2	-1.1	-1.1	0.9	-0.7
Patch foraging indifference point AUC	8.4	9.7	17.1	4.1	-2.8	-3.7	-3.7	-3.7	-0.4	1.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.6	1.3	-0.2	-0.7	-0.7	-1.0	-1.2	0.7
Delay disc. indifference point, 16s delay	2.5	2.5	7.1	-1.2	-0.8	0.7	0.7	1.1	2.6	-2.7
Delay disc. indifference point, 2s delay	0.6	0.7	1.6	-0.8	0.1	0.8	0.7	0.9	0.7	-1.3
Delay disc. indifference point, 24s delay	1.2	1.1	3.3	0.3	-1.2	-0.5	-0.4	-0.1	1.8	-1.6
Delay disc. indifference point, 4s delay	0.7	0.7	2.8	-0.4	-0.4	0.4	0.4	0.5	1.0	-1.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	-0.3	-0.0	0.3	0.3	0.2	0.3	-0.7
Indifference point function ln k	5.9	8.2	14.6	-3.8	2.9	3.4	3.4	3.4	-0.1	-0.7
Indifference point function log k	5.9	8.2	14.6	-3.8	2.9	3.4	3.4	3.4	-0.1	-0.7
Patch foraging total patch changes 0 sec	0.9	1.4	2.4	1.2	-1.5	-1.2	-1.2	-1.1	1.1	-1.0
Patch foraging total patch changes 12 sec	7.0	9.0	15.4	3.9	-3.1	-3.5	-3.5	-3.6	0.5	0.3
Patch foraging total patch changes 18 sec	3.5	4.5	8.9	3.0	-2.1	-2.4	-2.4	-2.4	0.0	0.1
Patch foraging total patch changes 24 sec	10.4	12.7	20.4	4.5	-3.8	-4.2	-4.2	-4.1	0.9	0.2
Patch foraging total patch changes 6 sec	5.6	8.2	11.5	3.4	-3.4	-3.4	-3.3	-3.1	1.6	-0.7
Patch foraging time to switch 0 sec	3.5	5.4	8.5	-2.9	2.4	2.8	2.8	2.8	-0.0	-0.2
Patch foraging water rate 0 sec	1.7	2.8	4.3	1.9	-2.1	-1.9	-1.8	-1.7	0.8	-0.8
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.1	0.2	0.3	0.3	0.4	-0.1	-0.2
Patch foraging water rate 18 sec	0.3	0.4	1.1	0.7	0.3	-0.1	-0.1	-0.2	-1.0	0.8
Patch foraging water rate 24 sec	1.6	2.2	4.0	1.4	-2.0	-1.5	-1.5	-1.1	1.5	-1.2
Patch foraging water rate 6 sec	0.2	0.3	0.8	-0.3	-0.1	0.3	0.4	0.5	0.7	-0.9
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	3.7	1.3	-1.9	-1.6	-1.6	-1.1	1.4	-0.7
Distance traveled before self-admin	3.1	3.3	5.6	2.4	-1.6	-2.2	-2.2	-2.0	-0.1	1.1
Distance traveled after self-admin	1.1	1.2	2.0	1.2	-1.1	-1.4	-1.4	-1.1	0.3	0.8
Extensor digitorum longus weight	0.1	0.5	1.7	-0.2	-0.6	0.0	0.0	0.3	1.1	-1.3
Bone: elastic displacement	0.2	0.2	0.5	0.1	-0.6	-0.3	-0.3	-0.3	0.7	-0.6
Bone: elastic work	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.6	-0.7	-0.2	0.4
Bone: endosteal estimation	0.8	1.8	5.8	-0.0	1.5	0.4	0.4	-0.0	-2.1	2.4
Bone: endosteal perimeter	0.5	1.1	3.6	-0.2	1.2	0.3	0.3	0.0	-1.5	1.9
Epididymis fat weight	0.5	1.2	3.4	0.5	0.7	-0.2	-0.2	-0.5	-1.8	1.9
Delta time in closed arm before/after self-admin	2.1	2.1	3.9	1.2	-2.0	-1.3	-1.3	-1.1	1.5	-1.6
Delta time in open arm before/after self-admin	1.7	1.7	4.4	-0.6	1.6	0.6	0.6	0.3	-1.8	2.1
Diff in mean of infusions in LGA sessions	0.5	0.5	1.9	-0.2	-0.7	-0.2	-0.2	0.1	1.4	-1.0
Delay discount exponential model param	1.0	1.1	3.8	0.7	0.4	-0.6	-0.6	-0.7	-1.4	1.9
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.4	-0.6	-0.5	-0.5	-0.5	0.5	-0.1
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.6	0.1	0.4	0.4	0.4	0.2	-0.4
Bone: final force	0.3	0.5	1.0	0.7	-0.1	-0.7	-0.7	-0.7	-0.7	1.0
Bone: final moment	0.4	0.7	1.0	1.0	-0.4	-0.9	-0.9	-0.9	-0.5	0.8
Food consumed during 24 hour testing period	0.1	0.2	0.6	0.3	0.2	-0.1	-0.1	-0.3	-0.5	0.8
Glucose	0.7	1.0	1.8	-0.4	1.3	1.0	1.1	0.7	-1.3	0.9
Heart weight	3.5	5.0	8.9	2.0	-3.0	-2.4	-2.3	-1.9	2.3	-1.5
Delay discount hyperbolic model param	1.0	1.1	3.6	0.8	0.3	-0.7	-0.7	-0.8	-1.3	1.9
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.1	0.3	0.1	0.2	0.3	-0.4	0.2
Intermittent access intake escalation	0.3	0.3	0.5	-0.3	0.6	0.6	0.6	0.7	-0.4	0.1
Intermittent access intake escalation 2	0.2	0.2	0.7	0.3	0.5	0.2	0.2	0.1	-0.8	0.6
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.6	-0.8	0.3	0.4	0.4	0.3	0.5	-0.3
Intermitt. access day 15 inactive lever presses	0.8	0.9	3.2	0.4	0.7	-0.2	-0.2	-0.6	-1.4	1.8
Intermitt. access escalation Index	2.2	1.9	3.5	1.9	-1.1	-1.7	-1.6	-1.7	-0.3	0.8
Intermittent access day 1 total infusions	2.9	3.3	5.9	-1.6	2.4	1.8	1.8	1.4	-2.2	1.2
Intermittent access day 15 total infusions	1.4	1.6	2.8	-0.9	1.7	1.2	1.2	1.1	-1.5	0.9
Intermittent access terminal intake (last 3 days)	3.7	4.1	7.8	-1.2	2.7	1.8	1.8	1.5	-2.8	1.7
Intermittent access total infusions	2.2	2.5	5.4	-0.9	2.1	1.3	1.3	1.0	-2.3	1.6
Intermittent access day 1 locomotion	0.7	0.7	1.2	-1.1	1.1	0.8	0.8	0.6	-0.8	0.6
Intermittent access day 15 total locomotion	0.8	0.9	2.0	-1.4	0.3	0.9	0.9	1.0	1.0	-1.0
Intermittent access total locomotion	1.6	1.9	3.0	-1.7	1.6	1.6	1.6	1.4	-0.7	0.1
Intermittent access standard deviation	0.6	0.7	1.3	-0.8	0.8	1.0	1.0	1.1	-0.3	-0.3
Left kidney weight	0.5	1.4	2.3	1.5	-0.5	-1.3	-1.3	-1.2	-0.6	1.4
Right kidney weight	1.3	3.7	6.5	2.5	-1.7	-2.3	-2.3	-2.3	-0.2	0.8
Cocaine induced anxiety	0.2	0.2	0.2	0.5	-0.5	-0.5	-0.5	-0.5	0.4	0.0
Post-drug Anxiety	0.9	1.0	1.6	-1.0	1.0	1.3	1.3	1.2	-0.2	-0.2
Baseline Anxiety	1.1	1.1	1.8	-1.1	1.1	1.3	1.3	1.3	-0.4	-0.3
Tail length	0.0	0.1	0.4	-0.5	0.0	0.2	0.2	0.3	0.7	-0.2
Length with tail	0.3	1.2	4.4	0.8	0.3	-0.6	-0.7	-1.0	-1.3	2.1
Length without tail	1.1	2.4	6.2	1.5	0.1	-1.1	-1.2	-1.6	-1.9	2.5
Times rat made contact with spout	0.5	0.5	1.9	0.1	0.8	0.1	0.1	-0.1	-1.2	1.4
Lifetime Intake	2.8	3.2	6.7	-1.2	2.4	1.5	1.5	1.0	-2.6	1.7
Liver weight, left	1.7	2.8	8.4	1.5	0.7	-0.6	-0.6	-1.2	-2.9	2.5
Liver weight, right	0.7	1.1	3.1	0.9	0.5	-0.4	-0.4	-0.7	-1.6	1.8
Locomotor activity	2.7	4.3	6.8	2.6	-0.5	-1.8	-1.8	-2.3	-2.2	2.5
Locomotor testing distance	2.2	3.7	6.3	2.5	-1.2	-2.0	-2.1	-2.4	-1.4	1.5
Locomotor testing rearing	3.1	4.7	8.0	2.7	-1.8	-2.5	-2.5	-2.8	-0.7	1.2
Locomotion in novel chamber	1.0	1.2	2.4	1.6	-0.7	-1.2	-1.2	-1.3	-0.8	0.6
Locomotion in novel chamber post-restriction	0.4	0.4	0.7	0.7	-0.4	-0.8	-0.8	-0.7	-0.2	0.7
Fecal boli incidents, locomotor time 1	0.7	0.8	2.0	1.0	0.2	-0.5	-0.5	-0.6	-1.2	1.4
Change in fecal boli incidents, locomotor task	3.4	3.2	5.0	1.8	-2.2	-2.1	-2.1	-1.9	1.4	-0.6
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.2	1.1	-0.7	-1.0	-0.9	-0.9	-0.1	0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.6	0.4	0.5	0.5	0.6	0.0	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.4	-0.6	0.6	0.6	0.6	0.6	-0.2	0.1
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	0.3	-0.1	0.0	0.1	-0.5	0.4
Distance moved, locomotor task time 1	0.8	0.9	1.6	0.7	-1.3	-1.0	-1.1	-1.0	0.9	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.4	-0.2	-0.4	-0.1	-0.2	-0.2	0.7	-0.1
Time >=10cm from walls, locomotor time 2	2.0	2.1	3.8	2.0	-0.7	-1.5	-1.5	-1.7	-1.3	1.3
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.4	-0.0	0.1
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.4	-0.5	-0.5	-0.5	-0.6	0.0	0.1
Rest time, locomotor task time 2	1.0	1.1	1.6	1.3	-1.2	-1.3	-1.2	-1.0	0.6	-0.3
Distance moved, locomotor task time 2	0.4	0.4	0.7	-0.7	0.7	0.8	0.8	0.7	-0.4	0.2
Vertical activity count, locomotor time 2	1.8	1.9	2.8	-1.4	1.7	1.6	1.7	1.5	-0.9	0.3
Light reinforcement 1	1.0	1.7	2.9	1.7	-0.9	-1.5	-1.5	-1.5	-0.3	1.1
Light reinforcement 2	1.0	1.4	2.1	1.4	-1.3	-1.4	-1.4	-1.2	0.4	0.3
Bone: marrow area	0.7	1.6	5.1	-0.1	1.4	0.4	0.4	-0.0	-1.9	2.3
Bone: maximum diameter	0.4	0.7	1.1	1.0	-0.6	-1.0	-1.0	-1.0	-0.3	0.6
Bone: maximum force	0.4	0.7	1.7	0.7	0.2	-0.5	-0.5	-0.7	-1.2	1.3
Bone: maximum moment	0.5	0.9	1.5	1.0	-0.2	-0.8	-0.8	-1.0	-1.0	1.2
Mean time between licks in bursts	4.2	5.8	9.3	-3.0	2.6	2.9	2.9	2.8	-0.8	-0.2
Mean num. licks in bursts	0.2	0.3	0.5	0.3	-0.7	-0.6	-0.6	-0.5	0.5	-0.2
Cd content in liver	0.5	0.5	1.8	0.6	0.5	-0.1	-0.0	-0.3	-1.3	1.1
Co content in liver	0.7	0.9	3.2	0.5	0.8	-0.0	-0.0	-0.3	-1.4	1.8
Cu content in liver	1.9	2.3	5.0	1.8	-0.1	-1.2	-1.2	-1.4	-1.7	2.2
Fe content in liver	0.2	0.2	0.7	0.1	0.4	0.0	0.0	-0.1	-0.8	0.7
K content in liver	1.2	1.2	2.0	1.2	-1.0	-1.3	-1.3	-1.4	-0.1	0.5
Mg content in liver	2.3	2.4	3.7	1.9	-1.3	-1.8	-1.8	-1.9	-0.3	1.0
Mn content in liver	0.1	0.1	0.1	-0.4	-0.0	0.2	0.2	0.1	0.4	-0.3
Na content in liver	1.2	1.2	1.9	1.2	-1.2	-1.3	-1.4	-1.3	0.4	-0.1
Rb content in liver	0.6	0.7	1.3	0.5	-1.1	-0.7	-0.7	-0.4	1.2	-0.9
Se content in liver	2.0	2.4	5.6	1.6	0.3	-0.9	-0.9	-1.4	-2.2	2.4
Sr content in liver	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.4	0.3	-0.3
Zn content in liver	0.3	0.4	0.6	-0.6	0.5	0.7	0.7	0.8	0.1	-0.5
Bone: minimum diameter	0.6	1.1	2.0	-0.8	1.4	0.9	0.8	0.6	-1.4	1.2
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	0.1	0.2	0.2	0.3	0.2	-0.3
Time in novel zone, hab. session 1	1.4	1.4	2.5	0.8	-1.6	-1.0	-1.0	-0.7	1.5	-1.3
Total zone transitions, hab. session 1	0.3	0.5	1.1	0.3	-0.9	-0.4	-0.4	-0.3	0.9	-1.0
Total locomotion distance, hab. session 1	0.6	0.9	2.3	0.4	-1.2	-0.5	-0.5	-0.2	1.4	-1.5
Locomotion velocity, hab. session 1	0.3	0.5	1.4	0.0	-0.8	-0.2	-0.2	-0.0	1.2	-1.2
Time in familiar zone, hab. session 2	0.3	0.3	0.5	-0.4	0.7	0.4	0.4	0.3	-0.5	0.7
Time in novel zone, hab. session 2	3.7	3.7	6.3	2.0	-2.5	-2.2	-2.2	-1.9	1.3	-1.0
Total zone transitions, hab. session 2	2.0	2.6	4.1	2.0	-1.1	-1.8	-1.8	-2.0	-0.7	1.3
Total locomotion distance, hab. session 2	1.2	1.6	2.9	1.7	-1.2	-1.5	-1.5	-1.5	-0.2	0.6
Locomotion velocity, hab. session 2	0.7	1.0	1.7	1.3	-0.8	-1.1	-1.1	-1.2	-0.3	0.5
Novel to familiar place preference ratio	5.0	5.1	9.3	1.6	-3.0	-2.0	-2.0	-1.5	2.9	-2.4
Novelty place preference	6.2	6.3	11.5	1.8	-3.4	-2.3	-2.3	-1.7	3.1	-2.6
Time in novel zone, NPP test	7.6	7.9	14.2	2.2	-3.8	-2.7	-2.7	-2.1	3.3	-2.6
Total zone transitions, NPP test	1.1	1.6	3.0	1.4	-0.1	-1.0	-1.0	-1.3	-1.6	1.7
Total locomotion distance, NPP test	0.5	0.7	1.3	1.0	-0.0	-0.6	-0.6	-0.8	-1.1	1.0
Locomotion velocity, NPP test	0.5	0.6	1.8	0.8	0.3	-0.3	-0.3	-0.6	-1.4	1.2
Intraocular pressure	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.1	-0.0	0.1	0.0
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.7	0.5	0.5	0.5	0.5	-0.2	0.3
Delta ambulatory time before/after self-admin	1.0	1.1	2.3	-1.5	0.5	1.1	1.1	1.3	0.7	-0.9
Parametrial fat weight	1.0	2.0	3.1	-1.8	1.4	1.7	1.7	1.7	-0.1	-0.4
Pavlov. Cond. lever latency	2.2	2.8	5.0	1.6	-2.2	-1.8	-1.8	-1.4	1.6	-0.9
Pavlov. Cond. magazine entry latency	1.6	2.0	2.9	-1.7	1.6	1.7	1.7	1.6	-0.5	-0.3
Pavlov. Cond. change in total contacts	2.4	2.6	3.9	-1.8	1.9	2.0	1.9	1.7	-0.9	0.2
Pavlov. Cond. index score	2.1	2.7	4.7	-1.5	2.2	1.8	1.8	1.5	-1.5	0.7
Pavlov. Cond. latency score	2.4	3.0	5.3	-1.6	2.3	1.9	1.9	1.5	-1.7	0.9
Pavlov. Cond. lever contacts	2.7	3.2	5.5	-1.7	2.3	2.0	2.0	1.6	-1.5	0.8
Pavlov. Cond. magazine entry number	1.9	2.3	3.4	1.8	-1.8	-1.8	-1.8	-1.7	0.6	0.1
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.9	1.3	0.1	-0.7	-0.7	-1.1	-1.5	1.7
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.6	-1.7	2.1	1.9	1.9	1.6	-1.4	0.5
Pavlov. Cond. response bias	1.4	1.7	2.6	-1.4	1.6	1.6	1.6	1.3	-0.8	0.0
Pavlov. Cond. lever latency	1.0	1.4	2.2	-1.3	1.3	1.5	1.5	1.4	-0.4	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.1	0.1	-0.2	-0.2	-0.2	-0.3	0.6
Pavlov. Cond. change in total contacts	0.8	1.1	2.8	0.9	-0.0	-0.8	-0.9	-1.1	-1.2	1.7
Pavlov. Cond. index score	0.3	0.4	0.7	0.6	-0.4	-0.7	-0.8	-0.8	-0.2	0.6
Pavlov. Cond. latency score	0.2	0.2	0.4	0.4	-0.2	-0.5	-0.5	-0.6	-0.2	0.6
Pavlov. Cond. lever contacts	1.0	1.3	2.1	1.1	-1.4	-1.4	-1.4	-1.3	0.8	-0.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.4	0.2	0.5	0.5	0.5	0.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	1.1	-0.2	-0.6	-0.6	-0.7	-0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.6	-0.3	-0.7	-0.7	-0.8	-0.4	0.8
Pavlov. Cond. response bias	0.4	0.6	0.9	0.8	-0.9	-1.0	-1.0	-0.9	0.3	0.2
Time in closed arm before self-admin	2.1	2.3	3.6	-1.9	1.7	1.8	1.8	1.6	-0.6	-0.1
Time in closed arm after self-admin	0.4	0.4	1.6	-0.0	-0.6	-0.0	-0.1	-0.2	0.7	-1.3
Time in open arm before self-admin	1.5	1.6	4.3	0.6	-1.6	-1.0	-0.9	-0.5	2.1	-1.3
Time in open arm after self-admin	0.6	0.6	1.0	0.9	-0.5	-1.0	-0.9	-0.7	0.1	1.0
Bone: periosteal estimation	0.3	0.5	1.7	0.0	0.7	0.1	0.1	-0.2	-1.2	1.3
Bone: periosteal perimeter	0.2	0.3	0.6	0.4	-0.2	-0.6	-0.6	-0.7	-0.4	0.8
Bone: post-yield work	0.9	1.3	3.8	0.1	1.3	0.4	0.4	0.1	-1.9	1.8
Progressive ratio test 1 active lever presses	0.4	0.4	1.4	-0.1	0.6	-0.0	-0.0	-0.2	-1.2	0.9
Progressive ratio test 1 breakpoint	0.5	0.6	1.8	-0.4	0.9	0.4	0.3	0.2	-1.4	1.0
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.2	0.1	0.2	-0.4	-0.4	-0.7	-0.7	1.1
Progressive ratio test 2 active lever presses	1.3	1.4	4.2	0.2	1.3	0.3	0.3	-0.0	-2.1	1.9
Progressive ratio test 2 breakpoint	1.1	1.3	3.9	0.5	1.0	-0.0	-0.0	-0.2	-1.9	2.0
Progressive ratio test 2 inactive lever presses	0.9	1.0	2.1	-0.6	1.4	0.7	0.6	0.4	-1.5	1.2
Incentive Sensitization - Responses	1.0	1.0	2.3	-0.3	1.4	0.6	0.7	0.5	-1.2	1.5
Incentive Sensitization - Breakpoint	1.2	1.2	2.6	-0.4	1.5	0.8	0.8	0.6	-1.3	1.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	0.6	-0.1	0.1
Progressive ratio	1.2	1.3	2.3	1.5	-1.3	-1.3	-1.3	-1.3	0.1	-0.1
Food seeking constrained by brief footshock	1.5	1.8	3.7	-1.5	0.2	1.2	1.2	1.4	1.3	-1.9
Seeking ratio, punishment vs. effort	2.5	3.1	5.6	-2.4	1.2	2.0	1.9	2.1	0.9	-1.2
Retroperitoneal fat weight	0.8	2.7	6.2	1.9	0.3	-0.9	-0.9	-1.4	-2.5	2.3
Reaction time number correct	0.4	0.6	1.9	0.2	0.7	0.2	0.2	-0.1	-1.4	1.3
Reaction time mean minus median	3.0	4.0	6.4	-2.4	1.9	2.4	2.4	2.5	-0.1	-0.5
Reaction time mean minus median AUC	1.3	1.7	3.0	-1.7	1.0	1.5	1.5	1.7	0.2	-0.6
Reaction time num false alarms	1.7	2.3	4.4	1.9	-1.4	-1.8	-1.8	-2.1	0.0	0.3
Reaction time num false alarms AUC	1.1	1.5	3.2	1.5	-1.1	-1.4	-1.4	-1.8	-0.2	0.3
Reaction time trials correct on left	0.4	0.6	1.9	0.2	0.7	0.2	0.2	-0.1	-1.4	1.3
Reaction time trials on left	0.5	0.7	2.0	0.1	0.9	0.3	0.3	0.1	-1.4	1.3
Reaction time mean	3.9	5.4	7.7	-2.8	2.6	2.8	2.8	2.8	-0.7	0.3
Reaction time mean AUC	3.7	5.0	7.4	-2.7	2.4	2.7	2.7	2.7	-0.6	0.1
Median of all reaction times	3.1	4.3	6.1	-2.5	2.3	2.4	2.5	2.5	-0.6	0.3
Reaction time omissions	2.8	3.8	6.1	-2.3	1.9	2.4	2.4	2.5	-0.3	-0.6
Reaction time false alarm rate	1.2	1.7	2.7	1.3	-1.5	-1.5	-1.5	-1.6	0.6	-0.5
Reaction time premature initiation rate	0.2	0.3	0.5	0.6	-0.5	-0.6	-0.6	-0.7	0.1	0.2
Reaction time premature initiations	0.3	0.4	0.9	0.6	0.1	-0.4	-0.4	-0.6	-0.8	1.0
Std. dev. reaction times	3.2	4.5	7.3	-2.7	2.1	2.5	2.5	2.7	-0.1	-0.5
Reaction time trials completed	0.5	0.7	2.0	0.1	0.9	0.3	0.3	0.1	-1.4	1.3
Reaction time trials AUC	0.4	0.6	1.9	0.1	0.9	0.3	0.4	0.1	-1.4	1.2
Run reversals in cocaine runway, females	0.5	0.5	1.5	-0.5	-0.4	0.2	0.3	0.5	1.0	-1.2
Run reversals in cocaine runway, males	5.2	5.0	7.8	-2.7	2.3	2.7	2.7	2.8	-0.5	-0.4
Latency to leave start box in cocaine runway	1.6	1.7	3.4	-1.8	1.3	1.6	1.5	1.4	0.3	-0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	0.9	-0.8	0.9	0.9	0.8	0.6	-0.3	0.3
Latency to leave start box in cocaine runway, M	2.0	1.9	4.1	-2.0	0.9	1.5	1.5	1.6	0.9	-1.0
Std. dev. time between licks in bursts	0.5	0.6	1.0	-0.5	1.0	0.8	0.8	0.7	-0.9	0.5
Total sessions with >9 infusions	1.8	2.0	3.6	-1.9	1.5	1.7	1.6	1.6	-0.5	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.0	0.3	0.1	0.1	-0.1	-0.3	0.5
Short access day 10 total inactive lever presses	1.0	1.1	2.2	0.6	-1.4	-0.8	-0.8	-0.7	1.5	-1.1
Short access day 1 total infusions	1.5	1.6	3.3	-1.0	1.7	1.1	1.0	0.6	-1.8	1.1
Short access day 10 total infusions	1.1	1.3	2.4	-0.9	1.5	0.9	0.9	0.6	-1.5	1.2
Short access total infusions	2.4	2.7	5.9	-1.2	2.2	1.4	1.3	0.8	-2.4	1.6
Short access day 1 locomotion	0.8	0.9	1.6	0.7	-1.0	-1.2	-1.3	-1.2	0.5	0.2
Short access day 10 total locomotion	0.9	1.0	1.9	-1.4	0.4	1.0	1.0	1.2	0.7	-1.1
Short access total locomotion	0.1	0.1	0.3	-0.4	0.4	0.2	0.2	-0.0	-0.5	0.4
One hour access (0.3 mA shock)	1.0	1.2	2.5	-0.5	1.5	0.7	0.7	0.3	-1.6	1.5
Compulsive drug intake	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	0.1	0.0	-0.2
One hour access (shock baseline)	1.1	1.3	2.7	-0.7	1.6	0.8	0.8	0.5	-1.6	1.5
Social response proportion	1.6	1.7	2.7	-1.1	1.6	1.6	1.6	1.6	-0.9	0.1
Social responses	0.1	0.2	0.5	0.3	-0.4	-0.2	-0.2	0.0	0.6	-0.7
Social time	1.8	2.4	4.5	-1.0	2.1	1.3	1.3	0.9	-2.1	1.6
Soleus weight	3.7	10.7	27.6	0.9	-4.0	-1.9	-1.9	-0.8	5.3	-4.8
Bone: stiffness	0.4	0.6	1.8	0.6	0.4	-0.3	-0.2	-0.4	-1.4	1.3
Tibialis anterior weight	0.1	0.4	0.6	0.6	-0.8	-0.7	-0.6	-0.4	0.7	-0.5
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.8	-0.6	1.3	0.8	0.8	0.7	-1.2	1.2
Time to tail flick, vehicle, after self-admin	1.0	1.1	4.2	0.3	1.0	0.2	0.2	-0.3	-2.1	1.5
Time to tail flick, test, before self-admin	1.7	1.7	5.3	0.0	-1.1	-0.1	-0.1	0.6	2.3	-2.2
Time to tail flick, test, after self-admin	1.7	1.7	6.0	0.0	-1.4	-0.2	-0.2	0.2	2.0	-2.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.2	0.6	0.4	0.3	0.1	-0.7	0.4
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	0.8	-0.8	-0.7	-0.8	-0.9	-0.1	-0.3
Tibia length	1.5	4.2	13.7	1.0	1.4	-0.2	-0.2	-1.0	-3.7	3.4
Ambulatory time before self-admin	3.8	4.0	6.9	2.6	-1.4	-2.4	-2.3	-2.2	-0.6	1.8
Ambulatory time after self-admin	0.2	0.3	0.5	0.4	-0.5	-0.7	-0.6	-0.4	0.1	0.6
Bone: tissue strength	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.2	-0.2	-0.2	0.3
Total heroin consumption	0.3	0.3	1.1	-0.2	-0.6	-0.2	-0.2	-0.0	1.0	-0.8
Bone: trabecular number	1.6	2.6	5.9	0.8	-2.0	-1.2	-1.1	-0.7	2.4	-2.0
Bone: trabecular spacing	2.0	2.5	7.9	0.9	1.1	-0.2	-0.2	-0.7	-2.7	2.8
Bone: trabecular thickness	2.1	2.5	4.1	-2.0	0.7	1.6	1.6	1.8	1.2	-1.8
Bone: trabecular tissue density	1.6	2.3	3.4	-1.7	1.7	1.8	1.8	1.7	-0.8	0.1
Water consumed over 24 hours	0.6	0.8	1.4	1.2	-0.5	-1.0	-1.0	-1.0	-0.4	0.8
Number of responses in last shaping day	0.5	0.5	0.9	1.0	-0.2	-0.7	-0.7	-0.7	-0.6	0.9